bone resorption

Summary

Summary: Bone loss due to osteoclastic activity.

Top Publications

  1. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
  2. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
  3. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
  4. pmc Matrix-embedded cells control osteoclast formation
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
    Nat Med 17:1235-41. 2011
  5. ncbi The molecular understanding of osteoclast differentiation
    Masataka Asagiri
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Tokyo 113 8549, Japan
    Bone 40:251-64. 2007
  6. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
  7. pmc TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    Yi Tang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 15:757-65. 2009
  8. ncbi RANKL-RANK signaling in osteoclastogenesis and bone disease
    Teiji Wada
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Trends Mol Med 12:17-25. 2006
  9. ncbi Therapeutic approaches to bone diseases
    G A Rodan
    Merck Research Laboratories, West Point, PA 19486, USA St Vincent s Institute of Medical Research, Melbourne 3065, Australia
    Science 289:1508-14. 2000
  10. ncbi Transforming growth factor-beta1 to the bone
    Katrien Janssens
    Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
    Endocr Rev 26:743-74. 2005

Detail Information

Publications359 found, 100 shown here

  1. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
    ..pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass...
  2. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  3. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily...
  4. pmc Matrix-embedded cells control osteoclast formation
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
    Nat Med 17:1235-41. 2011
    ..These results suggest that the rate-limiting step of matrix resorption is controlled by cells embedded within the matrix itself...
  5. ncbi The molecular understanding of osteoclast differentiation
    Masataka Asagiri
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Tokyo 113 8549, Japan
    Bone 40:251-64. 2007
    ..From the clinical point of view, RANKL signaling pathway has promise as a strategy for suppressing the excessive osteoclast formation characteristic of a variety of bone diseases...
  6. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  7. pmc TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    Yi Tang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 15:757-65. 2009
    Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this process are associated with skeletal diseases, such as Camurati-Engelmann disease (CED)...
  8. ncbi RANKL-RANK signaling in osteoclastogenesis and bone disease
    Teiji Wada
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Trends Mol Med 12:17-25. 2006
    ....
  9. ncbi Therapeutic approaches to bone diseases
    G A Rodan
    Merck Research Laboratories, West Point, PA 19486, USA St Vincent s Institute of Medical Research, Melbourne 3065, Australia
    Science 289:1508-14. 2000
    The strength and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts...
  10. ncbi Transforming growth factor-beta1 to the bone
    Katrien Janssens
    Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
    Endocr Rev 26:743-74. 2005
    ..important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation...
  11. ncbi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nat Rev Immunol 7:292-304. 2007
    ....
  12. ncbi IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology
    Steeve Kwan Tat
    Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 1 rue Gaston Veil, BP 53508, 44035 Nantes 1, France
    Cytokine Growth Factor Rev 15:49-60. 2004
    ..The interactions between these three groups are presented within the framework of bone resorption pathophysiology such as tumor associated osteolysis...
  13. pmc Functions of RANKL/RANK/OPG in bone modeling and remodeling
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arch Biochem Biophys 473:139-46. 2008
    The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone resorption has led to major advances in our understanding of how bone modeling and remodeling are regulated...
  14. pmc RANK is essential for osteoclast and lymph node development
    W C Dougall
    Immunex Corporation, Seattle, Washington 98101 USA
    Genes Dev 13:2412-24. 1999
    ..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation...
  15. ncbi Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005
    ..Here we show, by analysing Adrb2-deficient mice, that the sympathetic nervous system favours bone resorption by increasing expression in osteoblast progenitor cells of the osteoclast differentiation factor Rankl...
  16. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  17. ncbi Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
    Edith Bonnelye
    Laboratoire de Génomique Fonctionelle de Lyon, Université de Lyon UMR5242, CNRS INRA ENS Université Lyon1 IFR 128 Biosciences Lyon Gerland, 46, Allee d Italie, 69007 Lyon, France
    Bone 42:129-38. 2008
    ..It stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization...
  18. pmc Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention
    Sougata Karmakar
    Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Medical Center, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA 01605, USA
    Rheum Dis Clin North Am 36:385-404. 2010
    ..In this review, the authors discuss the current understanding of pathogenic mechanisms of bone erosion in RA and examine current therapeutic approaches to prevent this damage...
  19. ncbi Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast
    Xiao Chun Bai
    Department of Cell Biology, Southern Medical University, Guangzhou 510515, China
    J Biol Chem 280:17497-506. 2005
    ..or superoxide anion is involved in bone loss-related diseases by stimulating osteoclast differentiation and bone resorption and that receptor activator of NF-kappaB ligand (RANKL) is a critical osteoclastogenic factor expressed on ..
  20. ncbi Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    Chuwen Lin
    Bio X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    J Bone Miner Res 24:1651-61. 2009
    ..Our findings also indicated sclerostin is a promising target for preventing disuse osteoporosis...
  21. pmc Cellular and molecular mechanisms of bone remodeling
    Liza J Raggatt
    Faculty of Health Sciences, The University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Herston 4029, Australia
    J Biol Chem 285:25103-8. 2010
    Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis...
  22. pmc Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
    Christopher T Ritchlin
    Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Clin Invest 111:821-31. 2003
    Psoriatic arthritis (PsA) is an inflammatory joint disease characterized by extensive bone resorption. The mechanisms underlying this matrix loss have not been elucidated...
  23. ncbi Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
    R G G Russell
    Nuffield Department of Orthopaedic Surgery, Oxford University Institute of Musculoskeletal Sciences The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Osteoporos Int 19:733-59. 2008
    ..There is new knowledge about how they work. The differences that exist among individual BPs in terms of mineral binding and biochemical actions may explain differences in their clinical behavior and effectiveness...
  24. ncbi Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    Lorenz C Hofbauer
    Department of Gastroenterology, Philipps University, Marburg, Germany
    JAMA 292:490-5. 2004
    b>Bone resorption by osteoclasts is coupled with bone formation by osteoblasts, and this balanced process continuously remodels and adapts the skeleton...
  25. ncbi T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    H Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Nature 408:600-5. 2000
    b>Bone resorption is regulated by the immune system, where T-cell expression of RANKL (receptor activator of nuclear factor (NF)-kappaB ligand), a member of the tumour-necrosis factor family that is essential for osteoclastogenesis, may ..
  26. pmc DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 202:345-51. 2005
    ..We have thus identified an essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, and an essential role of osteoclast multinucleation in bone homeostasis...
  27. ncbi Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERK
    Estabelle Ang
    School of Surgery, The University of Western Australia, Nedlands, Western Australia 6009, Australia
    J Cell Biochem 112:89-97. 2011
    Osteolytic bone diseases such as osteoporosis have a common pathological feature in which osteoclastic bone resorption outstrips bone synthesis...
  28. pmc Autophagy proteins regulate the secretory component of osteoclastic bone resorption
    Carl J DeSelm
    Department of Pathology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 21:966-74. 2011
    ..LC3, are important for generating the osteoclast ruffled border, the secretory function of osteoclasts, and bone resorption in vitro and in vivo...
  29. ncbi Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption
    Alice Wattel
    Clinical Pharmacy Laboratory, Universite de Picardie Jules Verne, 1 rue des Louvels, 80000 Amiens, France
    Biochem Pharmacol 65:35-42. 2003
    ..Our results indicate that both compounds, at concentrations ranging from 0.1 to 100 microM reduce bone resorption in a time and dose-dependent manner...
  30. ncbi Experimental results of combining bisphosphonates with allograft in a rat model
    F Agholme
    Department of Clinical and Experimental Medicine, Section for Orthopaedics and Sports Medicine, Linkoping University, Linkoping, Sweden
    J Bone Joint Surg Br 91:670-5. 2009
    ..We suggest that bisphosphonates are likely to have a negative influence where resorption is a prerequisite to create space for new bone ingrowth...
  31. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
    ..a specialized inflammatory subset, as an osteoclastogenic Th cell subset that links T cell activation and bone resorption. The interleukin (IL)-23-IL-17 axis, rather than the IL-12-IFN-gamma axis, is critical not only for the onset ..
  32. ncbi Podosome and sealing zone: specificity of the osteoclast model
    Pierre Jurdic
    Laboratoire de Biologie Moléculaire et Cellulaire UMR 5161 CNRS ENS, IFR 128 BioSciences, Ecole Normale Superieure de Lyon, 46 allee d Italie, F 69007 Lyon, France
    Eur J Cell Biol 85:195-202. 2006
    The bone resorption function of osteoclasts is dependent on the integrity of the actin cytoskeleton...
  33. ncbi Expression of bone resorption genes in osteoarthritis and in osteoporosis
    Darja Bitenc Logar
    Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000, Ljubljana, Slovenia
    J Bone Miner Metab 25:219-25. 2007
    ..TRAP is a marker for osteoclasts, and there is increasing evidence of its proteolytic role in bone resorption. RANKL is a recently discovered regulator of osteoclast maturation and activity and induces expression of ..
  34. pmc Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    Shmuel Yaccoby
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 109:2106-11. 2007
    ..We conclude that DKK1 is a key player in MM bone disease and that blocking DKK1 activity in myelomatous bones reduces osteolytic bone resorption, increases bone formation, and helps control MM growth.
  35. ncbi TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..effects of TSH on both components of skeletal remodeling, osteoblastic bone formation, and osteoclastic bone resorption, mediated via the TSH receptor (TSHR) found on osteoblast and osteoclast precursors...
  36. pmc Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones
    M T Engsig
    OSTEOPRO A S and Center for Clinical and Basic Research, DK 2750 Herlev Ballerup, Denmark
    J Cell Biol 151:879-89. 2000
    ..Histological analysis and specialized invasion and bone resorption models show that MMP-9 is specifically required for the invasion of osteoclasts and endothelial cells into ..
  37. ncbi Osteoporosis and inflammation
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    Nutr Rev 65:S147-51. 2007
    ..Increased production of pro-inflammatory cytokines is associated with osteoclastic bone resorption in a number of disease states including rheumatoid arthritis, periodontitis, and multiple myeloma; estrogen ..
  38. pmc The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:6158-63. 2004
    ..syk(-/-) progenitors are similarly defective in osteoclast development and bone resorption. Intact SH2-domains of Syk, introduced by retroviral transduction, are required for functional reconstitution ..
  39. pmc Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    Guitty Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Invest 111:1221-30. 2003
    ..Moreover, in the merged groups, RANKL expression per cell correlated directly with the bone resorption markers, serum C-terminal telopeptide of type I collagen and urine N-telopeptide of type I collagen, in all ..
  40. ncbi IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions
    Haruka Kohara
    Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Immunol Lett 137:53-61. 2011
    ..following T cell activation, and directly promotes osteoclast differentiation resulting in accelerated bone resorption. Interferon-γ (IFN-γ) attenuates RANKL-initiated cellular signals through osteoclast formation and ..
  41. ncbi Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1
    Hiroshi Takatsuna
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    J Bone Miner Res 20:653-62. 2005
    ..DHMEQ, a newly designed NF-kappaB inhibitor, inhibited RANKL-induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor of osteoclastogenesis...
  42. pmc Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4
    Helen J Knowles
    Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, Oxford, OX3 7LD, UK
    FASEB J 24:4648-59. 2010
    ..factor (HIF) transcription factor regulate angiogenic-osteogenic coupling and osteoclast-mediated bone resorption. To determine how HIF might coordinate osteoclast and osteoblast function, we studied angiopoietin-like 4 (..
  43. pmc B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo
    Yan Li
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Blood 109:3839-48. 2007
    Bone homeostasis is regulated by a delicate balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclastogenesis is controlled by the ratio of receptor activator of NF-kappaB ligand (RANKL) relative to its ..
  44. ncbi Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts
    Meenakshi A Chellaiah
    Department of Oral Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 278:29086-97. 2003
    ..Neutralizing antibodies to alphav, beta3, or CD44 inhibited the migration and bone resorption of wild type osteoclasts...
  45. pmc Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength
    M Chellaiah
    Renal Division, Department of Medicine, Barnes Jewish Hospital, Washington University, St Louis, Missouri 63110, USA
    J Cell Biol 148:665-78. 2000
    ..binding to the alpha(v)beta(3) integrin of osteoclast podosomes stimulated cytoskeletal reorganization and bone resorption by activating a heteromultimeric signaling complex that includes gelsolin, pp(60c-src), and ..
  46. ncbi Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion
    Noushin Nabavi
    Department of Cell and Systems Biology, University of Toronto Scarborough, Toronto, Ontario, Canada
    Bone 49:965-74. 2011
    ..The absence of gravitational forces therefore causes both an increase in bone resorption by osteoclasts, and a decrease in osteoblast cellular integrity...
  47. pmc β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice
    Jianquan Chen
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63131, USA
    J Bone Miner Res 28:1160-9. 2013
    ..Thus, β-catenin in postnatal Osx-lineage cells critically regulates bone homeostasis by promoting osteoblast activity and suppressing osteoblast turnover, while restraining osteoclast and marrow fat formation...
  48. ncbi Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women
    E S Mackinnon
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8
    Osteoporos Int 22:1091-101. 2011
    ..with lycopene had significantly increased antioxidant capacity and decreased oxidative stress and the bone resorption marker N-telopeptide (NTx). Lycopene decreases bone resorption markers and may reduce the risk of osteoporosis...
  49. ncbi Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis
    Tsai Pei Hsieh
    School of Pharmacy, College of Pharmacy, Taipei Medical University, Taiwan, ROC
    Phytomedicine 18:176-85. 2011
    ..Our hypothesis is that icariin can inhibit osteoclast differentiation and bone resorption by suppressing MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis...
  50. ncbi Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL
    Paul J Kostenuik
    Metabolic Disorders Research, Amgen, Thousand Oaks, California 91320, USA
    J Bone Miner Res 24:182-95. 2009
    ..Recombinant human OPG-Fc recognizes RANKL from multiple species and reduced bone resorption and increased bone volume, density, and strength in a number of rodent models of bone disease...
  51. ncbi S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis
    Lilyanne C Grevers
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 63:1365-75. 2011
    ..The aim of the present study was to investigate the role of S100A8 and S100A9 in osteoclastic bone destruction in murine antigen-induced arthritis (AIA)...
  52. ncbi The osteoclast: friend or foe?
    Deborah V Novack
    Department of Pathology and Immunology, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Pathol 3:457-84. 2008
    ..In these diseases, osteoclast activity causes bone loss that leads to pain, deformity, and fracture. Thus, osteoclasts are critical for normal bone function, but their activity must be controlled...
  53. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
    ..attending this condition, the significance of which is reflected by similar blunting of the in vivo bone resorption marker tartrate-resistant acid phosphatase 5b (TRACP 5b)...
  54. ncbi Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis
    S Colucci
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Pathol 212:47-55. 2007
    Psoriatic arthritis (PsA) is an inflammatory joint disease, characterized by extensive bone resorption, whose mechanisms have not been fully elucidated...
  55. pmc Suppressive function of androgen receptor in bone resorption
    Hirotaka Kawano
    Institute of Molecular and Cellular Biosciences and Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 100:9416-21. 2003
    ..analyses of 8-week-old male AR knockout (ARKO) mice showed high bone turnover with increased bone resorption that resulted in reduced trabecular and cortical bone mass without affecting bone shape...
  56. ncbi Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    B D Gelb
    Department of Human Genetics and Division of Pediatric Cardiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 273:1236-8. 1996
    ..These findings suggest that cathepsin K is a major protease in bone resorption, providing a possible rationale for the treatment of disorders such as osteoporosis and certain forms of ..
  57. pmc The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    T L Burgess
    Department of Mammalian Cell Molecular Biology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
    J Cell Biol 145:527-38. 1999
    ..within 30 min) induces actin ring formation; a marked cytoskeletal rearrangement that necessarily precedes bone resorption. Furthermore, we show that antibodies raised against the OPGL receptor, RANK, also induce actin ring ..
  58. pmc A crucial role for thiol antioxidants in estrogen-deficiency bone loss
    Jenny M Lean
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Clin Invest 112:915-23. 2003
    ..This directly sensitizes osteoclasts to osteoclastogenic signals and entrains ROS-enhanced expression of cytokines that promote osteoclastic bone resorption.
  59. ncbi In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    ..process and the requirements of receptor activator of NF-kappaB (RANK) signaling in osteoclastogenesis and bone resorption, we investigated the efficacy of RANK blockade in preventing and ameliorating titanium (Ti)-induced ..
  60. pmc Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
    R Kitazawa
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri
    J Clin Invest 94:2397-406. 1994
    ..Ovx also increased bone resorption in vivo and in vitro, as assessed by the urinary excretion of pyridinoline cross links and the formation of ..
  61. pmc Control of RANKL gene expression
    CHARLES A O'BRIEN
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Bone 46:911-9. 2010
    ..The central role of RANKL in bone resorption is highlighted by the fact that it is the basis for a new therapy to inhibit bone loss...
  62. pmc Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
    Baohong Zhao
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo, Japan
    Nat Med 15:1066-71. 2009
    Bone metabolism results from a balance between osteoclast-driven bone resorption and osteoblast-mediated bone formation...
  63. ncbi Cell biology of the osteoclast
    G D Roodman
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Exp Hematol 27:1229-41. 1999
    ..The identification of the role of oncogenes such as c-fos and pp60 c-src in osteoclast differentiation and bone resorption have provided important insights in the regulation of normal osteoclast activity...
  64. pmc Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
    Tomonori Kaifu
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology CREST Program of the Japan Science and Technology Corporation JST, Tohoku University, Sendai, Japan
    J Clin Invest 111:323-32. 2003
    ..In vitro osteoclast induction from DAP12(-/-) bone marrow cells yielded immature cells with attenuated bone resorption activity...
  65. ncbi Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption
    Arpita Chakravarti
    Centre de Recherche en Rhumatologie et Immunologie CRRI, CRCHUL and Department of Medicine, Faculty of Medicine, Universite Laval, Quebec, QC, Canada
    Blood 114:1633-44. 2009
    ..7 cells, respectively, stimulated bone resorption. Transfection of PLB-985 neutrophil-like cells with RANKL antisense RNA reduced osteoclastogenesis...
  66. ncbi Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation
    Jenny M Lean
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    Endocrinology 146:728-35. 2005
    ..We found that catalase prevented ovariectomy-induced bone loss. These results suggest that hydrogen peroxide is the reactive oxygen species responsible for signaling the bone loss of estrogen deficiency...
  67. ncbi Osteoclastogenesis and arthritis
    Nicola Maruotti
    Department of Rheumatology, University of Foggia Medical School, Italy
    Clin Exp Med 11:137-45. 2011
    ..of juxta-articular bone and erosions due to the elevated activity of osteoclasts, which are involved in bone resorption. The main step in inflammatory bone erosion is an imbalance between bone resorption and bone formation: ..
  68. pmc Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
    Sarah Schmidt
    Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 192:883-97. 2011
    ..expressed on osteoclasts, which in turn abrogates the formation of podosomes and sealing zones required for bone resorption. In agreement with these findings, genetic ablation of all integrin classes abolishes the development of ..
  69. ncbi Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength
    Paul J Kostenuik
    Metabolic Disorders Research, M S 15 2 B, Amgen Inc, 1 Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Curr Opin Pharmacol 5:618-25. 2005
    ..Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are dominant regulators of bone resorption. Many hormones, cytokines and growth factors mediate bone resorption by altering the ratio of RANKL to OPG...
  70. ncbi Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation
    Jung Min Koh
    Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    J Bone Miner Res 21:1003-11. 2006
    ..Physiologic concentrations of Hcy directly activate osteoclast formation and activity through stimulation of p38 MAPK and integrin beta3. The effects of Hcy were mediated by generation of intracellular ROS...
  71. ncbi NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..We find that attenuated NOTCH signaling enhances osteoclastogenesis and bone resorption in vitro and in vivo by a combination of molecular mechanisms...
  72. ncbi Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption
    Young Sun Hwang
    Oral Cancer Research Institute, Yonsei University College of Dentistry, Republic of Korea
    Oral Oncol 48:40-8. 2012
    ..LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors...
  73. ncbi The regulation of cathepsin K gene expression
    Bruce R Troen
    Geriatrics Research, Education and Clincal Cancer Center and Research Services, Miami Veterans Affairs Medical Center, Miami, FL 33125, USA
    Ann N Y Acad Sci 1068:165-72. 2006
    Cathepsin K is essential for normal bone resorption. Osteoclasts synthesize and secrete cathepsin Kinto the extracellular compartment at the attachment site between osteoclasts and the bone surface, wherein the organic matrix is ..
  74. ncbi Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
    Kojiro Sato
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
    Nat Med 12:1410-6. 2006
    ..Thus, the CaMK-CREB pathway biphasically functions to regulate the transcriptional program of osteoclastic bone resorption, by not only enhancing induction of NFATc1 but also facilitating NFATc1-dependent gene regulation once its ..
  75. ncbi PTHrP regulates angiogenesis and bone resorption via VEGF expression
    Sachiko Isowa
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, 700 8525, Japan
    Anticancer Res 30:2755-67. 2010
    ..This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) produced by BC cells...
  76. pmc RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro
    Shuying Yang
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Bone Miner Res 22:45-54. 2007
    ..RGS12 may play a critical role in the RANKL-evoked PLCgamma-calcium channels-[Ca(2+)](i) oscillation-NFAT2 pathway...
  77. pmc Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
    Wei Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1858-66. 2008
    ..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis...
  78. ncbi NFATc1: functions in osteoclasts
    Qingxiao Zhao
    College of Chemical Engineering, Northeast Dianli University, Changchun Road 169, Jilin, PR China
    Int J Biochem Cell Biol 42:576-9. 2010
    ..In the present review, some of the known features of NFATc1 such as structure, function and its roles in physiological or pathophysiological processes are highlighted...
  79. ncbi Rheumatoid arthritis and periodontal disease
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 77:537-41. 2010
    ..g., scaling, root planing and, if needed, dental surgery), particularly as periodontitis is also associated with an increased risk of premature atheroma...
  80. ncbi IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss
    Mario M Zaiss
    Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    J Immunol 186:6097-105. 2011
    ..Thus, we show in this study that IL-33 is an important bone-protecting cytokine and may be of therapeutic benefit in treating bone resorption.
  81. ncbi The effect of zoledronic acid incorporated in a poly(D,L-lactide) implant coating on osteoblasts in vitro
    S Greiner
    Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Germany
    J Biomed Mater Res A 80:769-75. 2007
    ..Changes in sRANKL and OPG production may contribute to the inhibition of osteoclastic bone resorption. This local antiresorptive effect might be clinically useful in osseous implant integration and fracture ..
  82. ncbi Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases
    K Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Osteoporos Int 18:681-5. 2007
    Numerous experimental and clinical observations suggest that overall changes in bone resorption during menopause or treatment with hormone replacement therapy (HRT) are combined effects of changes in osteoclast number and function...
  83. ncbi Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy
    Wende Kozlow
    Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, 22908, USA
    J Mammary Gland Biol Neoplasia 10:169-80. 2005
    ..These factors and their roles in fueling the vicious cycle may identify novel targets for therapies to prevent metastasis...
  84. ncbi Rapid and robust response of biochemical markers of bone formation to teriparatide therapy
    Sarah J Glover
    University of Sheffield, Sheffield, UK
    Bone 45:1053-8. 2009
    ..increases in biochemical markers of bone formation after 1 month of therapy followed by a delayed increase in bone resorption markers...
  85. pmc Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction
    Norbert Kartner
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6 Canada
    J Biol Chem 285:37476-90. 2010
    ..Further understanding of these interactions and inhibitors may contribute to the design of novel therapeutics for bone loss disorders, such as osteoporosis and rheumatoid arthritis...
  86. pmc Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice
    Firas M Kara
    New York University School of Medicine, New York, NY, USA
    Arthritis Rheum 62:534-41. 2010
    Accelerated osteoclastic bone resorption plays a central role in the pathogenesis of osteoporosis and other bone diseases...
  87. ncbi Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofa
    Toshiyuki Yoneda
    Department of Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Bone Miner Metab 28:365-83. 2010
    ....
  88. pmc Osteoclasts have multiple roles in bone in addition to bone resorption
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Crit Rev Eukaryot Gene Expr 19:171-80. 2009
    ..Recent studies have identified functions for OCPs and osteoclasts in and around bone other than bone resorption. For example, they regulate the differentiation of osteoblast precursors and the movement of hematopoietic ..
  89. pmc Osteoclast motility: putting the brakes on bone resorption
    Deborah V Novack
    Department of Medicine, St Louis, MO 63110, USA
    Ageing Res Rev 10:54-61. 2011
    ..The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and ..
  90. ncbi Denosumab in postmenopausal women with low bone mineral density
    Michael R McClung
    Providence Portland Medical Center, Portland, Oreg, USA
    N Engl J Med 354:821-31. 2006
    ..The fully human monoclonal antibody denosumab (formerly known as AMG 162) binds RANKL with high affinity and specificity and inhibits RANKL action...
  91. ncbi The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
    William C Horne
    Department of Orthopaedics and Rehabilitation and Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Immunol Rev 208:106-25. 2005
    ..secretory domain (the ruffled border) and attachment-related cytoskeletal elements that are necessary for bone resorption. A key function of Src in osteoclasts is to promote the rapid assembly and disassembly of the podosomes, the ..
  92. ncbi Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection
    Robert E Miller
    Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
    J Immunol 179:266-74. 2007
    ..RANK-Fc inhibition of RANKL has antiosteoclast activity at doses that have no detectable immunoregulatory activity, suggesting that RANKL inhibitors be further studied for their potential to treat excess bone loss...
  93. pmc Control of bone resorption by semaphorin 4D is dependent on ovarian function
    Romain Dacquin
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS ONE 6:e26627. 2011
    ..It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal, environmental and genetic factors...
  94. pmc Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    M Neale Weitzmann
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri, USA
    J Clin Invest 110:1643-50. 2002
    ..bone loss stems from the inability of osteoblastic activity to match the increase in osteoclastic bone resorption induced by estrogen deficiency...
  95. ncbi Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation
    Estabelle S M Ang
    School of Dentistry, Oral Biology Research Laboratory, The University of Western Australia, Nedlands, WA 6009, Australia
    FEBS Lett 585:2755-62. 2011
    ..Osteolytic bone diseases including osteoporosis are commonly accompanied with enhanced osteoclast formation and bone resorption. Naringin, a natural occurring flavonoid has been found to protect against retinoic acid-induced osteoporosis ..
  96. ncbi The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis
    Tomoyuki Nakasa
    Department of Orthopaedic Surgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Arthritis Rheum 63:1582-90. 2011
    ..This study was undertaken to examine whether miR-146a expression inhibits osteoclastogenesis, and whether administration of miR-146a prevents joint destruction in mice with collagen-induced arthritis (CIA)...
  97. ncbi Impact of intra- and extra-osseous soft tissue composition on changes in bone mineral density with weight loss and regain
    Anja Bosy-Westphal
    the Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Obesity (Silver Spring) 19:1503-10. 2011
    ..In conclusion, changes in extra-osseous soft tissue composition had a minor contribution to changes in BMD with weight loss and decreases in bone marrow adipose tissue (BMAT) were not related to changes in BMD...
  98. ncbi Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression
    A M Parfitt
    Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Bone 30:5-7. 2002
  99. ncbi Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro
    Leilei Bao
    Department of Pharmacogonosy, School of Pharmacy, Second Military Medical University, Shanghai, China
    Chem Biol Interact 194:97-105. 2011
    ..1, 3, 8-trihydroxy-2-methoxy-anthraquinone (1), 2-hydroxy-1-methoxy-anthraquinone (2) and rubiadin (3) on bone resorption activity in vitro and the mechanism on osteoclasts derived from rat bone marrow cells...
  100. pmc Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro
    C Y Luo
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China
    Cell Mol Immunol 8:50-8. 2011
    ..we investigated the impact of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells on osteoclastogenesis and bone resorption. Treg cells that were isolated and purified from peripheral blood mononuclear cells (PBMCs) of healthy adults ..
  101. pmc An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption
    B S Herrera
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 2118, USA
    Br J Pharmacol 155:1214-23. 2008
    ..It was of interest to determine whether RvE1 has direct actions on osteoclast (OC) development and bone resorption.

Research Grants73

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..LPS induces leukocyte and monocyte-mediated inflammation that causes gingival tissue destruction and alveolar bone resorption. The gingival crevice deepens into a periodontal pocket, the periodontal ligament is destroyed, and the ..
  2. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..are critical regulators of basal bone homeostasis in young mice and mitigate in part, the enhanced bone resorption associated with aging"...
  3. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..translocate OC secretory vesicles to the RB and secrete their contents into the resorption lacuna to effect bone resorption. Under SA1...
  4. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone formation cells) and osteoclasts (bone resorption cells), respectively...
  5. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..local administration, (ii) explore th ability of GM-0111 to alter or block osteoclast activation and reduce bone resorption, (iii) test tolerability of topical formulations for delivery of GM-0111 into the sulcus in dose-ranging ..
  6. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..and bound water by nuclear magnetic resonance (NMR) to determine bone quality;analyze bone formation and bone resorption activities to determine bone remodeling status;analyze material testing of femur and biomechanical tests of ..
  7. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..Research advances have identified the mechanism of osteoclastogenesis and bone resorption, and provided new medications to arrest disease progression...
  8. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..EtOH, particularly at higher concentrations characteristic of binge drinking, can increase bone resorption. We have developed a new mouse model to study alcohol-induced bone loss in cycling females...
  9. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..effects of sex steroids are mediated by anabolic effects in osteoblasts, but more importantly by attenuating bone resorption. The anti-resorptive effects of sex steroids are attributable to both direct pro-apoptotic action in ..
  10. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..In our preclinical models, ionizing radiation rapidly activated osteoclastic bone resorption and caused a decline in trabecular-bone volume fraction of 20-30% during the seven to fourteen days after ..
  11. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..Bone changes are likely due to increased bone resorption, with little change in trabecular bone formation...
  12. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012
    ..The cysteine protease, cathepsin K (CTSK), is a major collagenase involved in osteoclastic bone resorption. In prostate cancer, CTSK levels are higher in bone metastases compared to corresponding primary tumors and ..
  13. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..unique osteoclastic protein-tyrosine phosphatase (PTP-oc) in osteoclastic cells led to a large increase in bone resorption and a marked decrease in bone mass in male but not female transgenic mice, compared to corresponding wild-..
  14. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..tissue that naturally and continually undergoes turnover with new bone formation by osteoblasts and old bone resorption by osteoclasts at a balanced rate;any imbalance between the two rates results in varying states of abnormal ..
  15. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..This hormone is involved in the complex regulation of blood calcium level by inhibiting bone resorption. Calcitonin is used therapeutically for the treatment of osteoporosis, Paget's disease, and ..
  16. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..loss as well as increased energy expenditure, higher catecholamines, reduced bone formation and increased bone resorption. In WAT depots, Misty had brown-like adipocytes suggesting that the SNS is compensating for loss of BAT but ..
  17. Regulation of glucose metabolism by bone resorption and gamma-carboxylation
    Mathieu Ferron; Fiscal Year: 2012
    ..The objective of the K99 mentored phase of this proposal is to understand the role of bone resorption as a regulator of glucose homeostasis...
  18. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A tight balance of bone formation and bone resorption (termed as the bone remodeling) maintains the homeostasis of the skeleton...
  19. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..The implementation of the TNBS model of chronic inflammatory bone resorption and the ligature-model of acute inflammatory bone loss will enable comparison of contribution of ROS to ..
  20. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    ..effects of sex steroids are mediated by anabolic effects in osteoblasts, but more importantly by attenuating bone resorption. The anti-resorptive effects of sex steroids are attributable to both increasing osteoclast apoptosis and ..
  21. Nuclear Events in PTH Action on Bone
    Nicola C Partridge; Fiscal Year: 2013
    ..The hormone acts through its G-protein-coupled receptor on the osteoblast to elicit enhanced bone resorption by the osteoclast. The osteoblast produces proteases in response to PTH...
  22. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..treat disease in rat models of MS, T1DM, RA, contact dermatitis, delayed type hypersensitivity (DTH) and bone resorption associated with periodontitis. These blockers have excellent safety profiles in animal models...
  23. Click chemistry for novel antimicrobials against periodontal pathogens
    Valery V Fokin; Fiscal Year: 2010
    ..Advanced stages of the disease lead to bone resorption and diminished tooth attachment...
  24. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..2) To compare the effects between VS-105 and calcitriol on bone resorption and formation in mouse calvariae bone primary organ culture...
  25. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..MM cells enhance bone resorption by triggering a coordinated increase in the receptor activator of nuclear factor-: B ligand (RANKL) and a ..
  26. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..of the etiology, osteoporosis is characterized by an imbalance in bone remodeling, such that osteoclastic bone resorption exceeds osteoblastic bone formation, which leads to low bone mass...
  27. STRUCTURE OF THE VACUOLAR ATPase
    Stephan Wilkens; Fiscal Year: 2013
    ..enclosed space between the ruffled membrane of osteoclasts and the bone surface plays an important role in bone resorption and remodeling...
  28. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..The menopausal transition is a period of critical change, including loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and depression...
  29. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..suggests a novel therapeutic target for the treatment of disorders characterized by osteoclast-mediated bone resorption. One of the most pressing public health problems for the aging population is the increasing fragility and ..
  30. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..osteocalcin (a marker of bone formation) and N-telopeptide of collagen 24 type I (NTx) (a marker of bone resorption). Serum estradiol and IGF-1 will also be assayed to confirm the 25 hormonal response to the protocol...
  31. Role of Gsalpha in Regulating Osteoblast Differentiation
    JOY Y WU; Fiscal Year: 2012
    ..is an extremely common degenerative disease resulting from an imbalance between bone formation and bone resorption. This discrepancy worsens with age, such that approximately 50% of women over the age of 50 will experience ..
  32. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..Biochemical and histomorphometric parameters for OCL differentiation and bone resorption will be determined in the following mice groups: i) wt, ii) NFATc1- CA-tg, iii) Atf4-/-, and iv) Atf4-/-;..
  33. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..of the etiology, osteoporosis is characterized by an imbalance in bone remodeling, such that osteoclastic bone resorption exceeds osteoblastic bone formation, which leads to low bone mass or osteopenia...
  34. The role of caspase-2 in osteoblast-osteoclast interactions
    DANIELLE ARDEN VICTOR; Fiscal Year: 2013
    ..marker, deoxypyridinoline (DPD), in urine, and increased numbers of osteoclasts, cells responsible for bone resorption. These results suggest that caspase-2 deficiency may prevent osteoclast spontaneous apoptosis, which is ..
  35. Connection of Mineral and Energy Metabolism by the Nuclear Receptor PPAR-gamma
    Yihong Wan; Fiscal Year: 2013
    ..tissue that constantly remodels by balancing osteoblast-mediated bone formation and osteoclast-mediated bone resorption. The disruption of this tissue homeostasis causes several devastating human diseases including osteoporosis, ..
  36. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ....
  37. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..osteocyte bone cells play in sensing mechanical damage and locally transmitting this signal to bring about bone resorption/formation...
  38. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..This hypothesis is based on recent studies demonstrating increased bone resorption, a remarkable loss of trabecular structures and an inhibition of periosteal expansion in animals injected ..
  39. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    Project Summary (Abstract) Osteoporosis, a silent debilitating bone disease, results when the rate of bone resorption (by osteoclasts) is much greater than the rate of bone formation (by osteoblasts) causing bone loss, deterioration of ..
  40. Protein Structure/Function by NMR, Crystallography and Computational Chemistry
    Eric Oldfield; Fiscal Year: 2012
    ..aureus (Aim 1), anti-fungal azoles with anti- bacterial activity (Aim 2) and bone resorption drugs that have immunomodulation or direct anti- bacterial activity (Aim 3)...
  41. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..produced clinical benefits such as improved bone density and reduced fracture risk by slowing osteoclastic bone resorption. The existing anti-resorptive drugs are plagued with untoward side effects and limited duration of clinical ..
  42. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ..have been shown to be safe and effective for the treatment of disorders associated with increased bone resorption in humans...
  43. Cathespin K Radioligands for In Vivo Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..protease that in highly expressed in osteoclasts and that is responsible for type I collagen degradation and bone resorption. The potential for in vivo imaging of cathepsin K has been demonstrated using optical methods, and this ..
  44. ERK Signaling in Inflammatory Bone Loss
    Francis Young In Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pathologic bone resorption due to osteoporosis, fragility fractures and cancers pose a significant economic burden to healthcare costs and lost wages...
  45. Connexin 43 in Bone Remodeling
    Roberto Civitelli; Fiscal Year: 2013
    ..the adult skeleton, and propose the following Specific Aims: 1) Mechanisms of Cx43 regulation of endocortical bone resorption, which will test the hypothesis that Cx43 regulates endocortical bone resorption via modulation of ..
  46. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
    ..to monitor by quantitative PCR and/or ELISA expression of the TLRs and monokines which are known to mediate bone resorption. Initial screens for involved TLRs and TLR-TLR cooperation will utilize TLR-targeted lentiviral shRNAmir ..
  47. CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA
    RICHARD ARTHUR CHOLE; Fiscal Year: 2013
    ..the mechanisms of PA LPS in host injury and response, specifically deregulated keratinocyte proliferation and bone resorption. We will examine the effect of lipopolysaccharide in the proliferation and differentiation of keratinocytes ..
  48. Pre-osteoclast fusion
    Paul R Odgren; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone resorption by osteoclasts (OCs) exceeding formation by osteoblasts (OBs) is a biological problem with a central role in widespread and costly disorders, including osteoporosis, osteo- and ..
  49. Phosphorylation of PTH1R by TGF-betaRII in Bone Remodeling
    Tao Qiu; Fiscal Year: 2013
    ..The pathogenesis is not only due to the increased osteoclast activity in bone resorption, but also a decrease in bone formation mostly attributed to an insufficient supply of osteoblasts in the aged...
  50. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ..with lipopolysaccharide and evaluate the consequence of increased chemokine expression on OCP recruitment and bone resorption in vivo...
  51. Renal Osteodystrophy: A Fresh Approach
    Hartmut H Malluche; Fiscal Year: 2012
    ..of ROD can be assessed noninvasively by PTH combined with established and/or novel biochemical markers of bone resorption and formation. The following specific aims will be pursued: 1...
  52. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
    ..The predominant treatment for osteoporosis is the use of drugs that block bone resorption (anti-resorptive or anti-catabolic agents)...
  53. Biomarker of Tissue Tolerance and Behavior in a Rat Model of WMSD
    Mary F Barbe; Fiscal Year: 2013
    ..to two task regimens, medium repetition-low force (MRLF) and high repetition-high force (HRHF), leads to bone resorption and pathological changes, and articular cartilage damage, and if the mechanism underlying these changes is ..
  54. Coloney Stimulating Factor 1 regulation and role in bone
    KARL LEONARD INSOGNA; Fiscal Year: 2010
    ..states of accelerated bone loss including estrogen-deficiency, inflammatory arthritis and malignancy-induced bone resorption. Alternative splicing of the CSF-1 gene results in production of soluble (sCSF1) and cell-surface (mCSF1) ..
  55. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
    ..demonstrated unequivocally that host immune responses play a key role in activating osteoclasts and promoting bone resorption in periodontal disease...
  56. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John J Wysolmerski; Fiscal Year: 2013
    ..The increase in circulating PTHrP, in turn, activates bone resorption and liberates calcium from the skeleton for milk production...
  57. Ginger Extracts in the Prevention of Metabolic Bone Disease
    LAURA ELIZABETH WRIGHT; Fiscal Year: 2011
    ..mediated through activation of the receptor activator of NF-kB (RANK) pathway, the final common pathway for bone resorption. Preliminary data indicate that well characterized crude ginger extracts are able to inhibit bone loss in ..
  58. ENDOSTEAL BONE VOLUME REGULATION AND OSTEOPOROSIS
    Subburaman Mohan; Fiscal Year: 2013
    ..Instead, this reduction in trabecular bone volume in Cldn-18 knockout mice is caused by increased bone resorption as reflected by increased osteoclast (OC) number that is not compensated by a corresponding increase in ..
  59. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..in RA pathogenesis by production of cytokines that drive inflammation, and osteoclasts mediate pathologic bone resorption. Osteoclast differentiation is dependent on the TNF family member RANKL...
  60. ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASS
    Hong Wen Deng; Fiscal Year: 2013
    ..Aim II: To characterize the role of RUNX1 gene in osteoclastogenesis and bone resorption. Identifying genes for human BMD variation and gaining insights into the fundamental molecular mechanisms of ..
  61. Functional Analysis of NHA-oc/NHA2 in vivo
    RICARDO ANIBAL BATTAGLINO; Fiscal Year: 2010
    ..Increased numbers and activity of osteoclasts, on the other hand, cause increased bone resorption, and may lead to osteoporosis and other osteolytic diseases...
  62. Effects of saliva on herpes simplex virus infection of oralcells
    CLAUDE F KRUMMENACHER; Fiscal Year: 2013
    ..gingival inflammation stimulated by bacterial colonization resulting in soft tissue destruction and alveolar bone resorption. Interestingly, herpes simplex virus 1 (HSV-1) is frequently associated with periodontal lesions...
  63. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..The rationales for hCT use in osteoporosis therapy are the stimulation of osteoblasts, specific inhibition of bone resorption by osteoclasts, and prevention of fusion of osteoclast precursors...
  64. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    ..The rationales for hCT use in osteoporosis therapy are the stimulation of osteoblasts, specific inhibition of bone resorption by osteoclasts, and prevention of fusion of osteoclast precursors...
  65. Novel RNAi Inhibits Both Inflammation and Bone Resorption in Oral Diseases
    Yi Ping Li; Fiscal Year: 2010
    ..novel treatment that will simultaneously prevent tissue damage and bone loss by reducing the inflammation and bone resorption caused by oral infectious and inflammatory diseases...
  66. Innate Immune Bacterial Recognition and Osteoclastogenesis
    Caroline A Genco; Fiscal Year: 2010
    ..In other inflammatory bone diseases these cells have been reported to contribute to the acceleration of bone resorption by the production of proinflammatory cytokines including tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-..
  67. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
    ..The resulting low estrogen levels, in turn, accelerate bone resorption and cause bone loss. In addition, the lactating breast secretes PTHrP into the systemic circulation and milk...
  68. Novel therapy for osteoporosis
    Emma Moore; Fiscal Year: 2009
    ..by an increased rate of bone remodeling;however, bone formation does not keep pace with increased bone resorption resulting in net loss of bone...
  69. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
    ..and activity and therefore influence normal and pathological osteoclastogenesis and osteoclast-mediated bone resorption. We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and ..
  70. Pathophysiology of Biphosphonate-Induced ONJ in a Novel Animal Model
    J Ignacio Aguirre; Fiscal Year: 2010
    ..that the incidence and severity of ONJ are associated with the potency of N-BPs to inhibit osteoclastic bone resorption and cumulative dose of these drugs, no mechanism-based cause and effect relationship has yet been established...
  71. SERUM OSTEOCLASTIC ACID PHOSPHATASE IMMUNOASSAY
    KIN HING LAU; Fiscal Year: 1993
    ..Adapted from the applicant's abstract): A convenient, sensitive, and accurate blood or urine test for bone resorption is needed for rapid diagnoses and close monitoring of the effectiveness of treatments of metabolic bone ..
  72. REGULATION OF BONE RESORPTION
    Julie Glowacki; Fiscal Year: 1991
    Complete understanding of the regulation of bone resorption by hormones and drugs could provide a rational basis for the treatment of metabolic bone diseases involving increased bone resorption (e.g...
  73. A Novel Long-Lived 41Ca Marker To Assess Bone Turnover For Breast Cancer Patients
    Susanta Hui; Fiscal Year: 2009
    ..We hypothesize that the 41Ca/Ca measurement in urine will offer (a) early detection of the accelerated bone resorption that result from the use of aromatase inhibitors, and (b) dynamic monitoring of the bone formation process ..