iga deficiency

Summary

Summary: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.

Top Publications

  1. ncbi The function of immunoglobulin A in immunity
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, UK
    J Pathol 208:270-82. 2006
  2. pmc Selective IgA deficiency
    Leman Yel
    University of California, Irvine, Irvine, CA, USA
    J Clin Immunol 30:10-6. 2010
  3. pmc Selective IgA deficiency in autoimmune diseases
    Ning Wang
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Med 17:1383-96. 2011
  4. doi Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
    Ricardo C Ferreira
    Genentech, Inc, South San Francisco, California, USA
    Nat Genet 42:777-80. 2010
  5. ncbi Mucosal immunity to influenza without IgA: an IgA knockout mouse model
    I N Mbawuike
    Departments of Microbiology, Influenza Research Center, Respiratory Pathogens Research Unit, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 162:2530-7. 1999
  6. ncbi HLA-A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 frequencies in German immunoglobulin A-deficient individuals
    H K Machulla
    Interbranch HLA Laboratory, Institute of Medical Immunology, Medical School, Martin Luther University of Halle Wittenberg, Germany
    Scand J Immunol 52:207-11. 2000
  7. doi Selective IgA deficiency: clinical and laboratory features of 118 children in Turkey
    Caner Aytekin
    Department of Pediatric Immunology, Dr Sami Ulus Maternity and Children s Health and Diseases Training and Research Hospital, 06080, Ankara, Turkey
    J Clin Immunol 32:961-6. 2012
  8. ncbi Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profiles
    Ana Paula França Mantovani
    Rheumatology Department, Hospital Universitario Evangelico de Curitiba, Faculdade Evangélica de Medicina do PR FEPAR, Curitiba, Brazil
    Rev Bras Reumatol 50:273-82. 2010
  9. doi Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and Sweden
    Javad Mohammadi
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Iran J Allergy Asthma Immunol 7:209-14. 2008
  10. ncbi Immunoglobulin levels in saliva in individuals with selective IgA deficiency: compensatory IgM secretion and its correlation with HLA and susceptibility to infections
    G Norhagen
    Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    J Clin Immunol 9:279-86. 1989

Research Grants

  1. IgA inducing peptide
    D Estes; Fiscal Year: 2005
  2. 2003 CIS Summer School
    Charlotte Cunningham Rundles; Fiscal Year: 2003
  3. TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIES
    Charlotte Cunningham Rundles; Fiscal Year: 2007
  4. Novel Gene Control of Lymphoid Tissue Development
    Rosemarie Seymour; Fiscal Year: 2007
  5. APRIL-TACI: Role in mucosal IgA and human IgA deficiency
    Emanuela Castigli; Fiscal Year: 2006
  6. Chemokine receptors and the interferon gamma pathway in Th1 cell trafficking
    Zamaneh Mikhak; Fiscal Year: 2007
  7. Primary Immune Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2007
  8. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 2001
  9. SECRETORY IMMUNOGLOBULIN
    MICHAEL LAMM; Fiscal Year: 2002
  10. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001

Detail Information

Publications213 found, 100 shown here

  1. ncbi The function of immunoglobulin A in immunity
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, UK
    J Pathol 208:270-82. 2006
    ..IgA function may also be perturbed in certain disease states, some of which are characterized by deposition of IgA in specific tissues. This review details current understanding of the roles played by IgA in both health and disease...
  2. pmc Selective IgA deficiency
    Leman Yel
    University of California, Irvine, Irvine, CA, USA
    J Clin Immunol 30:10-6. 2010
    ..Most individuals with IgA deficiency are asymptomatic and identified coincidentally...
  3. pmc Selective IgA deficiency in autoimmune diseases
    Ning Wang
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Med 17:1383-96. 2011
    ..This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders...
  4. doi Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
    Ricardo C Ferreira
    Genentech, Inc, South San Francisco, California, USA
    Nat Genet 42:777-80. 2010
    ..0 x 10(-4)) or random SNPs across the genome (P < 0.0001). These findings support the hypothesis that autoimmune mechanisms may contribute to the pathogenesis of IgAD...
  5. ncbi Mucosal immunity to influenza without IgA: an IgA knockout mouse model
    I N Mbawuike
    Departments of Microbiology, Influenza Research Center, Respiratory Pathogens Research Unit, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 162:2530-7. 1999
    ....
  6. ncbi HLA-A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 frequencies in German immunoglobulin A-deficient individuals
    H K Machulla
    Interbranch HLA Laboratory, Institute of Medical Immunology, Medical School, Martin Luther University of Halle Wittenberg, Germany
    Scand J Immunol 52:207-11. 2000
    ..Furthermore, for the first time this study reports a positive association of IgA deficiency with DPB1 alleles. Homozygosity rate for the gene loci DRB1 and DQB1 was increased in IgA deficiency...
  7. doi Selective IgA deficiency: clinical and laboratory features of 118 children in Turkey
    Caner Aytekin
    Department of Pediatric Immunology, Dr Sami Ulus Maternity and Children s Health and Diseases Training and Research Hospital, 06080, Ankara, Turkey
    J Clin Immunol 32:961-6. 2012
    Selective IgA deficiency (IgAD) is considered as the most common primary immunodeficiency...
  8. ncbi Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profiles
    Ana Paula França Mantovani
    Rheumatology Department, Hospital Universitario Evangelico de Curitiba, Faculdade Evangélica de Medicina do PR FEPAR, Curitiba, Brazil
    Rev Bras Reumatol 50:273-82. 2010
    b>IgA deficiency (IgAD) is the most common primary immunodeficiency, which can cause frequent infections...
  9. doi Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and Sweden
    Javad Mohammadi
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Iran J Allergy Asthma Immunol 7:209-14. 2008
    Selective IgA deficiency (IgAD) (serum IgA concentration of <0.07 g/l) is the most common primary immunodeficiency in Caucasians, with an estimated prevalence of 1/600...
  10. ncbi Immunoglobulin levels in saliva in individuals with selective IgA deficiency: compensatory IgM secretion and its correlation with HLA and susceptibility to infections
    G Norhagen
    Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    J Clin Immunol 9:279-86. 1989
    ..of IgA, IgM, and IgG were measured in unstimulated whole saliva and serum from 63 individuals with selective IgA deficiency. Values were compared with the incidence of upper respiratory tract infections, antibiotic treatments (..
  11. doi MSH5 is not a genetic predisposing factor for immunoglobulin A deficiency but marks the HLA-DRB1*0102 subgroup carrying susceptibility
    Nadia Del Pozo
    Clinical Immunology Department, Hospital Clinico, San Carlos, Madrid, Spain
    Hum Immunol 71:861-4. 2010
    The etiology of selective IgA deficiency (IgAD) is clearly influenced by human leukocyte antigen (HLA) genetic composition, although the susceptibility observed has not been ascribed to any specific gene/s...
  12. ncbi MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes
    Emilio G De la Concha
    Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
    J Immunol 169:4637-43. 2002
    Familial predisposition to IgA deficiency (IgAD) suggests that genetic factors influence susceptibility...
  13. ncbi Different clinical and laboratory evolutions in ataxia-telangiectasia syndrome: report of four cases
    W C Neves Forte
    Immunology Section, Santa Casa Medical School and Hospital, Sao Paulo, Brazil
    Allergol Immunopathol (Madr) 33:199-203. 2005
    ..sequence of the most commonly observed immunocompromised conditions were in our patients, in ascending order, IgA deficiency, IgG2 deficiency and the neutrophil phagocytosis stage and common variable immunodeficiency...
  14. ncbi Unusual absence of neurologic symptoms in a six-year old girl with ataxia-telangiectasia
    G G Trimis
    Pediatric Department of University of Athens, Greece
    J Postgrad Med 50:270-1. 2004
    ..It is concluded that a normal neurological assessment must not exclude the diagnosis of A-T and delay the proper interventional measures...
  15. ncbi Esophagus cancer and IgA deficiency in a patient with Dubowitz syndrome: a case report
    Ibrahim Halil Turkbeyler
    Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey
    Tokai J Exp Clin Med 36:29-30. 2011
    ..Esophageal mass biopsy revealed squamous cell carcinoma type. Both malignancy and IgA deficiency have been reported literature in patients with Dubowitz syndrome...
  16. pmc High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency
    Ricardo C Ferreira
    Genentech, South San Francisco, California, USA
    PLoS Genet 8:e1002476. 2012
    Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry...
  17. doi Profile of autoantibodies against phosphorylcholine and cross-reactivity to oxidation-specific neoantigens in selective IgA deficiency with or without autoimmune diseases
    Ana Elisa Fusaro
    Laboratório de Investigação em Dermatologia e Imunodeficiências, LIM 56, Faculdade de Medicina da USP, Instituto de Medicina Tropical de Sao Paulo, Sao Paulo, Brazil
    J Clin Immunol 30:872-80. 2010
    ..In conclusion, the IgG NatAbs against PC may represent a compensatory defense mechanism against infections and control excess of inflammation, explaining the asymptomatic status in the IgA deficiency.
  18. pmc High density of intraepithelial gammadelta lymphocytes and deposits of immunoglobulin (Ig)M anti-tissue transglutaminase antibodies in the jejunum of coeliac patients with IgA deficiency
    M Borrelli
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Clin Exp Immunol 160:199-206. 2010
    ..Intestinal IgM anti-TG2 and immunohistochemical markers do not discriminate between IgAD and potential CD with IgAD. Therefore, the serum IgG CD-associated autoantibodies remains very important for the diagnosis of CD in IgAD...
  19. ncbi Recurrent extended HLA haplotypes in children with selective IgA deficiency
    M Cuccia-Belvedere
    Dipartimento di Genetica e Microbiologia Università di Pavia, Italy
    Tissue Antigens 34:127-32. 1989
    ..supratypes as well as serum IgG, IgA and IgM levels were determined in 44 children and adolescents with severe IgA deficiency (serum IgA less than 5 mg/dl) and in first degree relatives...
  20. pmc The impact of an early truncating founder ATM mutation on immunoglobulins, specific antibodies and lymphocyte populations in ataxia-telangiectasia patients and their parents
    A Stray-Pedersen
    Department of Paediatrics, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 137:179-86. 2004
    ..58-1.26) g/l in the other patients (P = 0.002). Among the 11 A-T patients, six had IgG2 deficiency, six had IgA deficiency (three in combination with IgG2 deficiency) and seven had low/undetectable IgE values...
  21. ncbi Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency
    Francesco Cataldo
    Clinica Pediatrica R, University of Palermo, Palermo, Italy
    Pediatr Allergy Immunol 14:320-4. 2003
    Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD...
  22. doi Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findings
    Shiva Saghafi
    Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:157-62. 2008
    ..In this study we determined the incidence of selective IgA deficiency (SIgAD) in normal adult Iranian population. 13022 normal Iranian blood donors were included in this study...
  23. doi IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency
    Danilo Villalta
    Allergy and Immunology Unit, Azienda Ospedaliera San Maria degli Angeli, Pordenone, Italy
    Clin Chem 56:464-8. 2010
    ..IgA-anti-tTG are absent in IgA deficiency, a condition often associated with CD...
  24. ncbi Relative IgA deficiency and small intestinal bacterial overgrowth in German shepherd dogs
    R M Batt
    Department of Veterinary Pathology, University of Liverpool
    Res Vet Sci 50:106-11. 1991
    ..However, it is not clear whether such a defect is directly responsible for the overgrowth, or whether there is an indirect relationship between defective local immunity and bacterial overgrowth in German shepherd dogs...
  25. ncbi Membranous glomerulopathy in a patient with selective IgA deficiency: is there a link?
    A Vanacker
    Department of Nephrology, Heilig Hartziekenhuis Roeselare Menen, Roeselare, Belgium
    Acta Clin Belg 66:228-30. 2011
    ..Biochemistry showed a selective IgA deficiency (SIgAD)...
  26. ncbi Myelodysplastic syndrome with trisomy 8 in an adolescent with Fanconi anaemia and selective IgA deficiency
    G R Standen
    Department of Haematology, University of Wales College of Medicine, Cardiff, UK
    Am J Hematol 31:280-3. 1989
    ..Immune function studies also identified a selective IgA deficiency. The relative importance of interacting constitutional and exogenous factors involved in the development of ..
  27. ncbi Dermatitis herpetiformis and partial IgA deficiency
    Nancy J Samolitis
    Department of Dermatology, University of Utah Health Sciences Center, USA
    J Am Acad Dermatol 54:S206-9. 2006
    ..To date, no cases of IgA deficiency have been reported in DH...
  28. pmc Concomitant autoimmunity in myasthenia gravis--lack of association with IgA deficiency
    Ryan Ramanujam
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    J Neuroimmunol 236:118-22. 2011
    ..b>IgA deficiency (IgAD), which is strongly associated with the same HLA haplotype as early onset MG, has recently been ..
  29. ncbi Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndrome
    K Davies
    Department of Rheumatology, Great Ormond Street Hospital for Sick Children, London, UK
    J Rheumatol 28:2326-34. 2001
    ..Of particular interest is the occurrence of IgA deficiency in 4 patients, including 2 from our own series...
  30. pmc Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes
    H W Schroeder
    Department of Medicine, Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Mol Med 4:72-86. 1998
    A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell differentiation defects...
  31. pmc Role for Msh5 in the regulation of Ig class switch recombination
    Hideharu Sekine
    Medical University of South Carolina, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 104:7193-8. 2007
    ..We also present evidence that genetic variation in MSH5 is associated with IgA deficiency and common variable immune deficiency (CVID) in humans...
  32. ncbi Central MHC genes affect IgA levels in the human: reciprocal effects in IgA deficiency and IgA nephropathy
    Vance B Matthews
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
    Hum Immunol 63:424-33. 2002
    ..alleles of one or more genes in the central major histocompatibility complex (MHC) predispose carriers to IgA deficiency (IgAD) or IgA Nephropathy (IgAN)...
  33. ncbi TACI mutation in common variable immunodeficiency and IgA deficiency
    Rima Rachid
    Division of Immunology, Children s Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 6:357-62. 2006
    ....
  34. ncbi Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiency
    Yuki Asada
    Department of Internal Medicine, National Nagasaki Medical Center, 1001 1 Kubara, Omura, Japan
    World J Gastroenterol 12:5240-3. 2006
    ..Laboratory tests revealed low serum and saliva IgA levels, which might play a role in the development of UC. To our knowledge, this is the first case of UC occurring during the course of RA, accompanied by selective IgA deficiency.
  35. doi Autosomal recessive chronic granulomatous disease, IgA deficiency and refractory autoimmune thrombocytopenia responding to Anti-CD20 monoclonal antibody
    Bibi Shahin Shamsian
    Department of Pediatric Hematology Oncology, Immunology, Pathology, Mofid Children s Hospital, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:181-4. 2008
    ..granulomatous disease -the autosomal recessive type with mutation of NCF1 gene P47- associated with selective IgA deficiency, refractory immune thrombocytopenia that showed an excellent response to Rituximab (Anti-CD20 monoclonal ..
  36. ncbi [IgA, an essential part of the immune system: selected issues]
    Agnieszka Czyzewska-Buczyńska
    Katedra Propedeutyki Pediatrii, Klinika Immunologii i Reumatologii Wieku Rozwojowego Akademii Medycznej we Wrocławiu, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:38-47. 2006
    ....
  37. doi IgA deficiency: correlation between clinical and immunological phenotypes
    Asghar Aghamohammadi
    Department of Pediatrics, Division of Immunology and Allergy, Children Medical Center Hospital, Tehran University of Medical Sciences, 62 Gharib St, Keshavarz Blvd, 14194, Tehran, Iran
    J Clin Immunol 29:130-6. 2009
    b>IgA deficiency (IGAD) is the most common primary antibody deficiency. Although many affected individuals have no apparent symptom, selected patients suffer from recurrent mucosal infections, allergies, and autoimmune diseases...
  38. doi Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration
    Vincenzo Giambra
    Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    J Immunol 183:8280-5. 2009
    Selective IgA deficiency (IGAD) is the most common primary immunodeficiency, yet its pathogenesis is elusive. The IG (heavy) H chain human 3' Regulatory Region harbors three enhancers and has an important role in Ig synthesis. HS1...
  39. pmc Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study
    Javier Ortiz
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid
    BMC Med Genet 7:56. 2006
    b>IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Genetic and environmental factors are suspected to be involved in the development of the disease...
  40. pmc Individuals with IgA deficiency and common variable immunodeficiency share polymorphisms of major histocompatibility complex class III genes
    F M Schaffer
    Department of Pediatrics, University of Alabama at Birmingham 35294
    Proc Natl Acad Sci U S A 86:8015-9. 1989
    b>IgA deficiency and common variable immunodeficiency are heritable disorders that can occur within the same family...
  41. ncbi Role of IgA in the defense against respiratory infections IgA deficient mice exhibited increased susceptibility to intranasal infection with Mycobacterium bovis BCG
    Ariane Rodriguez
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Vaccine 23:2565-72. 2005
    ..Altogether, our results suggest that IgA may play a role in protection against mycobacterial infections in the respiratory tract by blocking the pathogen entrance and/or by modulating the pro-inflammatory responses...
  42. ncbi IgG2, IgG4 and IgA deficiency possibly associated with carbamazepine treatment
    Zenichiro Kato
    Eur J Pediatr 162:209-11. 2003
  43. doi Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiency
    Mototsugu Tanaka
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Pediatr Nephrol 25:2355-8. 2010
    We report a case of Henoch-Schönlein purpura nephritis (HSPN) with acquired IgA deficiency due to parvovirus B19 infection...
  44. ncbi Physiology of IgA and IgA deficiency
    C Cunningham-Rundles
    Department of Medicine and Pediatrics, Mount Sinai Medical Center, New York, New York 10029, USA
    J Clin Immunol 21:303-9. 2001
    Although secretory immunoglobulin A (IgA) is important in mucosal immunity. selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness...
  45. ncbi Bronchial hyper-responsiveness in selective IgA deficiency
    Athina Papadopoulou
    Department of Allergology Pulmonology, Penteli Children s Hospital, P Penteli, Greece
    Pediatr Allergy Immunol 16:495-500. 2005
    ..The insufficient protection provided by the respiratory mucosa in children with selective IgA deficiency (sIgAD) might facilitate the development of bronchial hyper-responsiveness (BHR) and consequently asthma ..
  46. doi Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper
    Cristina M A Jacob
    Instituto da Criança, Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Rua Oscar Freire 1961 apto 24 Cerqueira César CEP 05409 011 São Paulo, Brasil
    J Clin Immunol 28:S56-61. 2008
    Both systemic and organ-specific autoimmune diseases are major manifestations of IgA deficiency (IgAD), the most common primary immunodeficiency...
  47. ncbi Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency
    Jana Kralovicova
    Division of Human Genetics, School of Medicine, Southampton University Hospital, University of Southampton, Southampton, United Kingdom
    J Immunol 170:2765-75. 2003
    Selective IgA deficiency (IgAD) and common variable immunodeficiency (CVID) are the most common primary immunodeficiencies in humans...
  48. ncbi IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, 960 1295, Fukushima City, Fukushima, Japan
    Pediatr Nephrol 20:662-4. 2005
    Selective IgA deficiency associated with glomerulonephritis is rare and no previous reports in childhood have been made of the association of IgA deficiency and membranous glomerulonephritis (MGN)...
  49. ncbi IgA deficiency: clinical correlates and responses to pneumococcal vaccine
    Eki Edwards
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Immunol 111:93-7. 2004
    ..024). There was no relationship between a history of recurring infections and pneumococcal vaccine responses; HLA status was not related to a history of autoimmunity...
  50. pmc Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
    Qiang Pan-Hammarstrom
    Nat Genet 39:429-30. 2007
  51. pmc Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q
    Alejandro A Schäffer
    Department of Health and Human Services, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38A Rm 6S608 8600 Rockville Pike, Bethesda, MD 20894, USA
    Hum Genet 118:725-9. 2006
    ..immunodeficiency (CVID) is an antibody deficiency syndrome that often co-occurs in families with selective IgA deficiency (IgAD). Vorechovský et al...
  52. ncbi TACI is mutant in common variable immunodeficiency and IgA deficiency
    Emanuela Castigli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:829-34. 2005
    ..that 4 of 19 unrelated individuals with common variable immunodeficiency (CVID) and 1 of 16 individuals with IgA deficiency (IgAD) had a missense mutation in one allele of TNFRSF13B (encoding TACI)...
  53. ncbi Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L
    Zaheed Husain
    The CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
    J Clin Immunol 26:113-25. 2006
    b>IgA deficiency is the most common primary immunodeficiency in humans...
  54. ncbi Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
    Emanuela Castigli
    Nat Genet 39:430-1. 2007
  55. doi Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic
    Kelly E McGowan
    Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada
    Clin Chem 54:1203-9. 2008
    b>IgA deficiency causes false-negative IgA-based celiac serology results in patients with celiac disease...
  56. ncbi Primary immunodeficiency disorders: antibody deficiency
    Mark Ballow
    Division of Allergy Clinical Immunology and Pediatric Rheumatology, Department of Pediatrics, Children s Hospital of Buffalo, SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo 14222, USA
    J Allergy Clin Immunol 109:581-91. 2002
    ..As discussed in this review, this has led to a better elucidation of the B-cell development and differentiation pathways and a more complete understanding of the pathogenesis of many of these antibody deficiencies...
  57. doi Familial aggregation of IgAD and autoimmunity
    Gudmundur H Jorgensen
    Department of Medicine, University of Iceland, Reykjavik, Iceland
    Clin Immunol 131:233-9. 2009
    ..The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families...
  58. doi Selective IgA deficiency in early life: association to infections and allergic diseases during childhood
    Magdalena Janzi
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
    Clin Immunol 133:78-85. 2009
    Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood...
  59. doi Various expression patterns of alpha1 and alpha2 genes in IgA deficiency
    Hiroko Suzuki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergol Int 58:111-7. 2009
    b>IgA deficiency (IgAD) is the most common immunodeficiency, however the pathogenesis in most cases of IgAD is unknown...
  60. doi Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency
    Stephan Borte
    Department of Clinical Immunology and Transfusion Medicine, University of Leipzig, D 04103 Leipzig, Germany
    Blood 114:4089-98. 2009
    ..immunoglobulin production in B cells from patients with common variable immunodeficiency (CVID) or selective IgA deficiency (IgAD)...
  61. ncbi Fine mapping of IGAD1 in IgA deficiency and common variable immunodeficiency: identification and characterization of haplotypes shared by affected members of 101 multiple-case families
    I Vorechovsky
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Immunol 164:4408-16. 2000
    To limit the region containing a mutation predisposing to selective IgA deficiency (IgAD) and common variable immunodeficiency (CVID), 554 informative members of 101 multiple-case families were haplotyped at the IGAD1 candidate locus in ..
  62. doi The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency
    K Haimila
    Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland
    Genes Immun 10:151-61. 2009
    b>IgA deficiency (IgAD) and common variable immunodeficiency (CVID) often co-occur in families, associating with chronic inflammatory diseases such as celiac disease (CD)...
  63. ncbi [Epidemiological study of selective IgA deficiency among 6 nationalities in China]
    L Feng
    Beijing Children s Hospital
    Zhonghua Yi Xue Za Zhi 72:88-90, 128. 1992
    The frequency of selective IgA deficiency (SIgAD) was determined in 33,171 Chinese distributed in six nationalities by Ouchterlony's double diffusion with 5 mg/dl as the limit of detection...
  64. pmc Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition
    I Vorechovsky
    Karolinska Institute, Department of Biosciences at Novum, Huddinge, Sweden
    Am J Hum Genet 64:1096-109. 1999
    ..Such pathogenic mechanisms may be shared by other MHC-linked complex traits associated with the production of specific autoantibodies, parental effects, and a particular MHC haplotype...
  65. ncbi Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes
    G R Harriman
    Departments ofMedicine, Pediatrics, Pathology, and Molecular and Human Genetics, Howard Hughes Medical Institute, Houston, TX 77030, USA
    J Immunol 162:2521-9. 1999
    A murine model of IgA deficiency has been established by targeted deletion of the IgA switch and constant regions in embryonic stem cells. B cells from IgA-deficient mice were incapable of producing IgA in vitro in response to TGF-beta...
  66. ncbi Selective IgA deficiency and coeliac disease
    P Collin
    Dept of Clinical Sciences, University of Tampere, Finland
    Scand J Gastroenterol 27:367-71. 1992
    Twenty-five children and adults with concomitant coeliac disease and selective IgA deficiency are described. IgG-class reticulin antibodies were positive in 94%...
  67. doi Clinical assessment and management of abnormal IgA levels
    Frederick M Schaffer
    Section of Pulmonary, Allergy, and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
    Ann Allergy Asthma Immunol 100:280-2. 2008
  68. doi Progression of selective IgA deficiency to common variable immunodeficiency
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology, Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Int Arch Allergy Immunol 147:87-92. 2008
    Selective IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Although it is often asymptomatic, selected patients show an increased frequency of infections, allergies and autoimmune manifestations...
  69. ncbi Selective IgA deficiency (SIgAD) in Eastern Nigeria
    A C Ezeoke
    Department of Chemical Pathology, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Anambra State
    Afr J Med Med Sci 17:17-21. 1988
    Fifteen cases of selective IgA deficiency were found among 3772 children. Six had IgA levels of 0.01 g/l both in their serum and saliva, and had associated allergic disorders...
  70. doi Role of polymorphisms in the TNFRSF13B (TACI) gene in Spanish patients with immunoglobulin A deficiency
    R López-Mejías
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 74:42-5. 2009
    ..Therefore, our work seems to discard a role of TNFRSF13B mutations in IgAD, concordantly with the most recent published studies...
  71. ncbi Immunohistochemical findings in the intestine of IgA-deficient persons: number of intraepithelial T lymphocytes is increased
    T Klemola
    Children s Hospital, University of Helsinki, Finland
    J Pediatr Gastroenterol Nutr 7:537-43. 1988
    ..05 compared with pre-challenge specimens). The increase in IEL number in the jejunal mucosa of IgAdp probably indicates ineffective antigen exclusion...
  72. pmc IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency. Working Groups on Celiac Disease of SIGEP and Club del Tenue
    F Cataldo
    Clinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy
    Gut 47:366-9. 2000
    In selective IgA deficiency (IgAD), there is no reliable screening test for coeliac disease (CD).
  73. ncbi Major histocompatibility complex haplotypes in Spanish immunoglobulin A deficiency patients: a comparative fine mapping microsatellite study
    L Gual
    Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 64:671-7. 2004
    ..The results obtained also indicated that the most likely susceptibility gene in the DR7 haplotypes is either DQA1 or DRB1...
  74. pmc Bacterial lipopolysaccharide induces long-lasting IgA deficiency concurrently with features of polyclonal B cell activation in normal and in lupus-prone mice
    T Cavallo
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912
    Clin Exp Immunol 84:134-8. 1991
    ..Because immune defects are common in autoimmune diseases and IgA deficiency is prevalent in patients with systemic lupus erythematosus, we investigated: (i) whether LPS might induce IgA ..
  75. ncbi HLA antigens in IgA deficient paediatric patients
    T Klemola
    Children s Hospital, University of Helsinki, Finland
    Tissue Antigens 32:218-23. 1988
    ..The IgA deficiency in the patients showed significant associations with HLA A1, B8, B13, Cw6, DR3 and DR7 (P less than 0...
  76. ncbi A putative susceptibility locus on chromosome 18 is not a major contributor to human selective IgA deficiency: evidence from meiotic mapping of 83 multiple-case families
    I Vorechovsky
    Karolinska Institute at NOVUM, Center for Biotechnology, Huddinge, Sweden
    J Immunol 163:2236-42. 1999
    ..and low levels of IgA suggested that this chromosome contains a susceptibility locus for selective IgA deficiency (IgAD), the most frequent Ig deficiency in humans...
  77. ncbi Low prevalence of IgA deficiency in north Indian population
    Shelly Chandran
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 123:653-6. 2006
    ..No data are available from India. We did a blood donor survey to look for prevalence of IgA deficiency in north India.
  78. ncbi Epistatic effects occurring among susceptibility and protective MHC genes in IgA deficiency
    A Martinez
    Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Genes Immun 4:316-20. 2003
    ....
  79. pmc Intracellular cytokine production by Th1/Th2 lymphocytes and monocytes of children with symptomatic transient hypogammaglobulinaemia of infancy (THI) and selective IgA deficiency (SIgAD)
    D Kowalczyk
    Department of Clinical Immunology, Polish American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland
    Clin Exp Immunol 127:507-12. 2002
    ..in lymphocytes and monocytes of children with transient hypogammaglobulinaemia of infancy (THI) and selective IgA deficiency (SIgAD)...
  80. ncbi Colocalization of lichen planus and vitiligo associated with selective IgA deficiency
    Ulker Gul
    Second Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Skinmed 6:202-3. 2007
    ..Melanocytes were decreased in number, and in some areas they were absent at the basal layer of epidermis. Clinical and histopathologic diagnosis were consistent with lichen planus and vitiligo (Figure 2)...
  81. ncbi Cytokine genotyping (TNF and IL-10) in patients with celiac disease and selective IgA deficiency
    F Cataldo
    Clinica Pediatrica R, Sezione di Patologia Generale, University of Palermo, Palermo, Italy
    Am J Gastroenterol 98:850-6. 2003
    Selective IgA deficiency (IgAD) and celiac disease (CD) are frequently associated and share the ancestral haplotype human leukocyte antigen (HLA)-8.1, which is characterized by a peculiar cytokine profile...
  82. ncbi Diagnostic accuracy of coeliac serological tests: a prospective study
    Glenn E M Reeves
    Hunter Area Pathology Service HAPS, John Hunter Hospital, Newcastle, NSW 2310, Australia
    Eur J Gastroenterol Hepatol 18:493-501. 2006
    ....
  83. ncbi Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac disease
    P G Hill
    Department of Chemical Pathology, Haematology and Immunology, Derbyshire Royal Infirmary, Derby Hospitals NHS Foundation Trust, Derby DE1 2QY
    Ann Clin Biochem 43:105-17. 2006
    ....
  84. ncbi Total and relative deficiency of gut mucosal IgA in German shepherd dogs demonstrated by faecal analysis
    R M Littler
    Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield
    Vet Rec 158:334-41. 2006
    ..The faecal concentrations of immunoglobulin G and albumin were significantly higher in the German shepherd dogs than in the controls, but their immunoglobulin M concentrations were similar...
  85. ncbi Immunoglobulin A and CD8 T-cell mucosal immune defenses protect against intranasal infection with Chlamydia pneumoniae
    A Rodriguez
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Scand J Immunol 63:177-83. 2006
    ..pneumoniae infections...
  86. pmc Do we need to measure total serum IgA to exclude IgA deficiency in coeliac disease?
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    J Clin Pathol 59:736-9. 2006
    Screening for IgA deficiency in patients with coeliac disease is essential because of the increased incidence of IgA deficiency associated with the disease, which usually relies on the estimation of IgA levels in each case.
  87. ncbi Oral manifestations in selective IgA deficiency
    J Nikfarjam
    Pediatric Dentistry Department, Faculty of Dentistry, Tehran University of Medical Science, Tehran, Iran
    Int J Dent Hyg 2:19-25. 2004
    ..Previous studies show contradictory results, concerning the involvement of the individuals' periodontium with IgA deficiency. The aim of this study was to investigate and compare the oral manifestations in IgA-deficient subjects with ..
  88. ncbi Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency
    Rong Jin
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Int J Mol Med 21:233-8. 2008
    ..Elevated BAFF and APRIL expression levels might partially reflect the common immunological feature of primary antibody deficiency...
  89. ncbi Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract in patient with selective immunoglobulin A deficiency and sarcoid-like syndrome--case report
    M Piascik
    Department of Gastroenterology, Central Clinical Hospital of Ministry of Home Affairs, Warsaw, Poland
    Adv Med Sci 52:296-300. 2007
    ..In this case report we focus on clinical presentation and differential diagnosis of diffuse nodular lymphoid hyperplasia of the gastrointestinal tract coexisting with selective immunoglobulin A deficiency and sarcoid-like syndrome...
  90. ncbi Rheumatologic manifestations in patients with selected primary immunodeficiencies evaluated at the University Hospital
    María L Santaella
    Clinical Immunology Division, Rheumatology Section, Department of Medicine, University of Puerto Rico School of Medicine, P O Box 365067, San Juan, Puerto Rico 00936 5067
    P R Health Sci J 24:191-5. 2005
    ..To characterize an IgA deficient and common variable immunodeficiency (CVI) group of patients in terms of the presence of rheumatologic manifestations...
  91. doi Restricted immunoglobulin constant heavy G chain genes in primary immunodeficiencies
    Vivi Anne Oxelius
    Department of Pediatrics and Institute of Clinical Immunology, University Hospital, Lund University, SE 221 85 Lund, Sweden
    Clin Immunol 128:190-8. 2008
    ..6) and 21 Wiscott-Aldrich syndrome (OR 4.1). 62 IgA deficiency patients were dominated by both diplotypes (OR 2.3 and OR 2.8 respectively)...
  92. ncbi The clinical significance of immunoglobulin A deficiency
    Amir H Abdul Latiff
    Division of Clinical Immunology and Allergy, Department of Paediatrics, Faculty of Medicine and Health Sciences, Universiti Putra, Serdang, Malaysia
    Ann Clin Biochem 44:131-9. 2007
    b>IgA deficiency is the most common primary immunoglobulin deficiency. The prevalence in Caucasians is around one in 500, whereas in some Asian populations it is very uncommon...
  93. ncbi No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and Guatemala
    Aamir J Khan
    Department of International Health, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Room W5041, Baltimore, MD 21205, USA
    Biologicals 34:113-6. 2006
    ..Nevertheless, persistent poliovirus excretion among persons 2 years of age and older with residual paralytic poliomyelitis is uncommon in developing countries...
  94. ncbi Alterations in humoral immunity in relatives of patients with common variable immunodeficiency
    A Aghamohammadi
    Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    J Investig Allergol Clin Immunol 18:266-71. 2008
    ..The aim of this study was to determine the prevalence of immunoglobulin deficiency in relatives of patients with CVID in Iran, where there is a high rate of consanguineous marriage...
  95. ncbi Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assays
    Danilo Villalta
    Immunologia Clinica e Virologia, AO S Maria degli Angeli, Via Montereale 24, Pordenone, Italy
    Clin Chim Acta 382:95-9. 2007
    To evaluate the diagnostic characteristics of commercially available IgG anti-tTG assays in selective IgA deficiency (SIgAD), we tested different IgG anti-tTG methods and compared the results with those obtained from two other tests: one ..
  96. ncbi Clinical inquiries: What blood tests help diagnose celiac disease?
    Bonzo K Reddick
    Department of Family Medicine, University of North Carolina, Chapel Hill, NC, USA
    J Fam Pract 55:1088, 1090, 1093. 2006
    ..IgA tTG and IgA EMA offer the best diagnostic accuracy. Patients with selective IgA deficiency may have falsely negative IgA assays (strength of recommendation [SOR]: B, based on a systematic review, ..
  97. ncbi Enterobacterial 38-kDa outer membrane protein is an age-dependent molecular marker of innate immunity and immunoglobulin deficiency as results from its reactivity with IgG and IgA antibody
    Danuta Witkowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    FEMS Immunol Med Microbiol 48:205-14. 2006
    ..These data correlated with total IgA and IgG levels in immunoglobulin-deficient children. The results indicate that this protein may serve as an immunodiagnostic marker, but also as an antigen carrier in vaccines...
  98. ncbi Selective IgA deficiency in children and adults with systemic lupus erythematosus
    J T Cassidy
    Department of Child Health, Pediatric Rheumatology, University of Missouri School of Medicine, Columbia, MO, USA
    Lupus 16:647-50. 2007
    The objective of this study was to determine the frequency and clinical characteristics of selective IgA deficiency (SIgAD) in children and adults with systemic lupus erythematosus (SLE), and evaluate potential differences in presentation ..
  99. ncbi The four most common pediatric immunodeficiencies
    Richard E Stiehm
    Mattel Children s Hospital, David Geffen School on Medicine, UCLA, Los Angeles, CA, USA
    Adv Exp Med Biol 601:15-26. 2007
    ..deficiency, partial antibody deficiency with impaired polysaccharide responsiveness (IPR), and selective IgA deficiency IgAD. None are life threatening, all can be readily managed, and many recover spontaneously...
  100. ncbi Further aspects of human immunoglobulin A deficiency
    J R Hobbs
    Ann Clin Biochem 44:496-7. 2007
  101. ncbi Kabuki syndrome with trichrome vitiligo, ectodermal defect and hypogammaglobulinemia A and G
    Raffaella Zannolli
    Department of Pediatrics, Section of Neurology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Brain Dev 29:373-6. 2007
    ..Our report may provide important clues for understanding the pathogenesis of the KS...

Research Grants82

  1. IgA inducing peptide
    D Estes; Fiscal Year: 2005
    ..We also hypothesize that altered IGIP regulation in dendritic cells and/or B cells is a factor in selective IgA deficiency. The specific aims that will test this hypothesis are: 1) Use an established in vitro model to determine the ..
  2. 2003 CIS Summer School
    Charlotte Cunningham Rundles; Fiscal Year: 2003
    ..The participants will be drawn from training programs, hospitals and institutions that are in North, Central or South America. Only fellows from the United States will receive funding made possible through the NIH grant. ..
  3. TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIES
    Charlotte Cunningham Rundles; Fiscal Year: 2007
    ..abstract_text> ..
  4. Novel Gene Control of Lymphoid Tissue Development
    Rosemarie Seymour; Fiscal Year: 2007
    ..b>IgA deficiency is a common form of immune deficiency in humans, and has also been implicated in autoimmunity...
  5. APRIL-TACI: Role in mucosal IgA and human IgA deficiency
    Emanuela Castigli; Fiscal Year: 2006
    ..Selective IgA deficiency is the most common immunodeficiency affecting 1/300 to 1/700 individuals, approximately half of whom suffer ..
  6. Chemokine receptors and the interferon gamma pathway in Th1 cell trafficking
    Zamaneh Mikhak; Fiscal Year: 2007
    ....
  7. Primary Immune Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2007
    ..Principle topics will focus on: Diagnosis of Immunodeficiency; Genetics, Immune Reconstruction, and the Use of Standard and Novel Therapies. ..
  8. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 2001
    ..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
  9. SECRETORY IMMUNOGLOBULIN
    MICHAEL LAMM; Fiscal Year: 2002
    ....
  10. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ....
  11. 2002 Summer School in Primary Immunodeficiency Disorders
    Charlotte Cunningham Rundles; Fiscal Year: 2002
    ..Fellows participating in the course will be reimbursed for their travel expenses. No registration fee will be charged for the fellows participating in the program. ..
  12. Vulnerability to Smallpox Due to Declining CTL Immunity
    Innocent Mbawuike; Fiscal Year: 2003
    ..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
  13. SECRETORY IMMUNOGLOBULIN
    MICHAEL LAMM; Fiscal Year: 1993
    ..The insights afforded should aid in developing practical strategies for mucosal immunization...
  14. Primary Immunne Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2005
    ..Principle topics will focus on: Antibody Deficiency; Combined Immune Defects; Neutrophil Disorders; Laboratory Evaluation of Primary Immunodeficiency; Immune Reconstiution, and the Use of Standard and Novel Therapies. ..