blood group incompatibility

Summary

Summary: A mismatch between donor and recipient blood. Antibodies present in the recipient's serum are directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Top Publications

  1. ncbi ABO-incompatible kidney transplantation using both A2 and non-A2 living donors
    James M Gloor
    Division of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 75:971-7. 2003
  2. pmc MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 208:2525-44. 2011
  3. doi Clinical outcome of ABO-incompatible living unrelated donor kidney transplantation
    Junji Uchida
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Urol Int 86:307-14. 2011
  4. doi ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodies
    Cassandra D Josephson
    Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfus Apher Sci 42:83-8. 2010
  5. ncbi Hyperhemolytic transfusion reaction attributable to anti-Fy3 in a patient with sickle cell disease
    M A Reyes
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Immunohematology 24:45-51. 2008
  6. ncbi Spectrum and outcome analysis of marked neonatal hyperbilirubinemia with blood group incompatibility
    Yi Hao Weng
    Division of Neonatology, Department of Pediatrics, Chang Gung Children s Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:400-8. 2009
  7. ncbi Xenotransplantation and ABO incompatible transplantation: the similarities they share
    Uri Galili
    Department of Medicine, University of Massachusetts Medical School, LRB, Worcester, MA 01605, USA
    Transfus Apher Sci 35:45-58. 2006
  8. ncbi Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitors
    P A Arndt
    American Red Cross Blood Services, Pomona, CA 90006, USA
    Transfus Med 15:125-32. 2005
  9. ncbi Significant numbers of apheresis-derived group O platelet units have "high-titer" anti-A/A,B: implications for transfusion policy
    C D Josephson
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 44:805-8. 2004
  10. doi Clinical outcomes of ABO-incompatible RBC transfusions
    Kim A Janatpour
    Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento 95817, USA
    Am J Clin Pathol 129:276-81. 2008

Research Grants

  1. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2010
  2. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
  3. Erythrocyte Complement Receptor 1 in Transfusion/Malaria
    Karina Yazdanbakhsh; Fiscal Year: 2005
  4. Immunoregulatory responses in patients with ITP
    Karina Yazdanbakhsh; Fiscal Year: 2009
  5. Immunoregulatory responses in patients with ITP
    Karina Yazdanbakhsh; Fiscal Year: 2010
  6. Studies of rHuTPO in ITP and of rVlla in Liver Disease
    David Kuter; Fiscal Year: 2006
  7. Pediatric Transfusion Medicine Academic Career Award
    CASSANDRA JOSEPHSON; Fiscal Year: 2007
  8. Genetics of Anorexia Nervosa
    Bernie Devlin; Fiscal Year: 2006
  9. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2006
  10. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2010

Detail Information

Publications194 found, 100 shown here

  1. ncbi ABO-incompatible kidney transplantation using both A2 and non-A2 living donors
    James M Gloor
    Division of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 75:971-7. 2003
    ..Given the scarcity of cadaveric organs, efforts are intensifying to increase the availability of living donors. The current study assessed the feasibility of using ABO-incompatible living-donor kidneys to expand the donor pool...
  2. pmc MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 208:2525-44. 2011
    ..These observations have important implications for the prevention and treatment of TRALI...
  3. doi Clinical outcome of ABO-incompatible living unrelated donor kidney transplantation
    Junji Uchida
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Urol Int 86:307-14. 2011
    ..ABO-incompatible living unrelated donor kidney transplantation is an immunologically high-risk procedure, but few reports have been made on the outcomes of these transplants...
  4. doi ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodies
    Cassandra D Josephson
    Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfus Apher Sci 42:83-8. 2010
    ..The progress in this European strategy may serve the US to stimulate a re-examination of its practices and policies for the advancement of platelet transfusion safety...
  5. ncbi Hyperhemolytic transfusion reaction attributable to anti-Fy3 in a patient with sickle cell disease
    M A Reyes
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Immunohematology 24:45-51. 2008
    ..To the best of our knowledge, this is the first published case of hyperhemolysis in sickle cell disease attributable to anti-Fy3...
  6. ncbi Spectrum and outcome analysis of marked neonatal hyperbilirubinemia with blood group incompatibility
    Yi Hao Weng
    Division of Neonatology, Department of Pediatrics, Chang Gung Children s Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:400-8. 2009
    ..In the current study, we investigate the spectrum and outcome of marked neonatal hyperbilirubinemia with blood group incompatibility.
  7. ncbi Xenotransplantation and ABO incompatible transplantation: the similarities they share
    Uri Galili
    Department of Medicine, University of Massachusetts Medical School, LRB, Worcester, MA 01605, USA
    Transfus Apher Sci 35:45-58. 2006
    ..Such tolerance is perpetuated indefinitely by the subsequent transplantation of the organ expressing the incompatible blood group antigen...
  8. ncbi Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitors
    P A Arndt
    American Red Cross Blood Services, Pomona, CA 90006, USA
    Transfus Med 15:125-32. 2005
    ..We suggest that babies born to mothers with anti-Ge should have their haemoglobin concentrations monitored for signs of anaemia for several weeks after birth. Functional assays may prove useful...
  9. ncbi Significant numbers of apheresis-derived group O platelet units have "high-titer" anti-A/A,B: implications for transfusion policy
    C D Josephson
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 44:805-8. 2004
    ..Based on these data, a policy was instituted to test anti-A/A,B titers in O SDPs prior to "out-of-group" transfusion...
  10. doi Clinical outcomes of ABO-incompatible RBC transfusions
    Kim A Janatpour
    Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento 95817, USA
    Am J Clin Pathol 129:276-81. 2008
    ..Prompt recognition and discontinuation of the transfusion are critical because transfusing less ABO-incompatible blood may minimize signs and symptoms and may prevent death...
  11. ncbi Anti-AB titer changes in patients with ABO incompatibility after living related kidney transplantations: survey of 101 cases to determine whether splenectomies are necessary for successful transplantation
    H Ishida
    Department of Surgery III, Tokyo Women s Medical University, Japan
    Transplantation 70:681-5. 2000
    ..Here, the pre- and posttransplantation anti-AB titers in patients who received transplants from ABO-incompatible living donors are reviewed and the pathological findings are compared...
  12. ncbi Plasma exchange conditioning for ABO-incompatible renal transplantation
    J L Winters
    Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 19:79-85. 2004
    ..Controlled clinical trials are needed to identify the optimum conditioning for ABO-incompatible renal transplants...
  13. doi [An experience of ABO-incompatible kidney transplantation using plasmapheresis and anti-CD20 monoclonal antibody]
    Hee Won Moon
    Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea
    Korean J Lab Med 29:585-8. 2009
    ..The kidney transplantation was successful without any sign of hyperacute or acute rejection...
  14. doi Biliary complications after 52 adult living donor liver transplantations: a single-center experience
    H Iwamoto
    5th Department of Surgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
    Transplant Proc 40:2539-41. 2008
    ..The incidence of biliary complications after adult living donor liver transplantation (ALDLT) are still high even though various devices have been reported to overcome them...
  15. doi The role of immunomodulation in ABO-incompatible adult liver transplant recipients
    Lucio Urbani
    Liver Transplant Unit, Azienda Ospedaliero Universitaria Pisana, Ospedale Cisanello, Pisa, Italy
    J Clin Apher 23:55-62. 2008
    ....
  16. ncbi Successful case of adult ABO-incompatible liver transplantation: beneficial effects of intrahepatic artery infusion therapy: a case report
    Y Nakamura
    Fifth Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Transplant Proc 36:2269-73. 2004
    ..We report a successful case of adult ABO-incompatible liver transplantation with the use of an intrahepatic artery infusion...
  17. ncbi [ABO-incompatible liver transplantation for liver failure]
    Yang Yang
    Liver Transplant Center, Third Affiliated Hospital of Sun Yat Sen University, Transplantation Research Institute of Sun Yat sen University, Guangzhou 510630, China
    Zhonghua Yi Xue Za Zhi 87:2833-6. 2007
    ..To evaluate the efficacy of ABO-incompatible orthotopic liver transplantation (OLT) in treatment of liver failure...
  18. ncbi ABO-incompatible kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 78:635-40. 2004
    ..Here we review the therapeutic options for patients whose only living kidney donor is ABO incompatible, with a specific emphasis on the rationale for and the current outcomes of ABO incompatible living donor kidney transplantation...
  19. ncbi Therapeutic strategy and the role of apheresis therapy for ABO incompatible living donor liver transplantation
    Koichi Kozaki
    Department of Transplantation Immunology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ther Apher Dial 9:285-91. 2005
    ..In this article, we describe our therapeutic strategy and the role of apheresis around ABO-incompatible LDLT...
  20. doi ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis
    Zoe A Stewart
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Liver Transpl 15:883-93. 2009
    ..Liver Transpl 15:883-893, 2009. (c) 2009 AASLD...
  21. ncbi Histologic findings of antibody-mediated rejection in ABO blood-group-incompatible living-donor kidney transplantation
    Mary E Fidler
    Department of Laboratory Medicine, Division of Anatomic Pathology, Mayo Foundation and Clinic, Rochester, MN, USA
    Am J Transplant 4:101-7. 2004
    ..Glomerular thrombi appear early in AMR and may appear prior to graft dysfunction...
  22. ncbi Present status of ABO-incompatible living donor liver transplantation in Japan
    Hiroto Egawa
    Japanese registry working group, Division of Liver Transplantation, Japan Study Group for ABO Blood Type Incompatible Transplantation, Japan
    Hepatology 47:143-52. 2008
    ....
  23. doi Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors
    D Toki
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Transplant 9:567-77. 2009
    ....
  24. pmc Liver transplantation across Rh blood group barriers increases the risk of biliary complications
    Juli Busquets
    Department of Surgery, Hospital Universitari de Bellvitge, Barcelona, Spain
    J Gastrointest Surg 11:458-63. 2007
    ..An ABO-incompatible blood group has also been suggested as a factor for predisposal towards BC. However, the influence of Rh nonidentity has not been studied previously...
  25. ncbi A Comparison of splenectomy versus intensive posttransplant antidonor blood group antibody monitoring without splenectomy in ABO-incompatible kidney transplantation
    James M Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 80:1572-7. 2005
    ....
  26. ncbi Successful ABO-incompatible pediatric liver transplantation utilizing standard immunosuppression with selective postoperative plasmapheresis
    Thomas Heffron
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Liver Transpl 12:972-8. 2006
    ..In conclusion, our outcomes may support the concept of using ABO-I grafts in a more elective setting associated with split and living donor liver transplants...
  27. ncbi Successful ABO-incompatible liver transplantation using A2 donors
    U Skogsberg
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Transplant Proc 38:2667-70. 2006
    ..We herein have reported our experience with ABO-incompatible liver transplantation using A(2) donors to blood group O recipients...
  28. ncbi Removal of maternal antibodies from a woman with repeated fetal loss due to P blood group incompatibility
    H Yoshida
    Department of Transfusion Medicine, Kyoto University Hospital, Japan
    Transfusion 34:702-5. 1994
    ..The infant did not require an exchange transfusion and is now a healthy 2-year-old boy. CONCLUSION: This therapeutic method is very useful in the management of fetomaternal P-incompatibility...
  29. ncbi Prenatal genotyping of the Duffy blood group system by allele-specific polymerase chain reaction
    M J Hessner
    The Diagnostic Laboratories of The Blood Center, Milwaukee, WI 53233, USA
    Prenat Diagn 19:41-5. 1999
    ..This assay is particularly useful for rapid genotyping of fetal amniotic cells to identify pregnancies at risk for HDN due to maternal fetal incompatibilities within the Duffy blood group system...
  30. ncbi Molecular testing for transfusion medicine
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Curr Opin Hematol 13:471-5. 2006
    ..This review summarizes the progress made in the last decade in applying genotyping to prenatal practice and clinical transfusion medicine...
  31. pmc RHD positive haplotypes in D negative Europeans
    F F Wagner
    Abteilung Transfusionsmedizin, Universitatsklinikum Ulm and DRK Blutspendedienst Baden Württemberg, Institut Ulm, Ulm, Germany
    BMC Genet 2:10. 2001
    ..Excluding RHDpsi and CdeS frequent only in individuals of African descent, most of these alleles are unknown and the population frequency of any such allele has not been determined...
  32. ncbi Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia
    A Maria Elfving
    Department of Pediatrics, Lund University, Lund, Sweden
    Autoimmunity 36:111-5. 2003
    b>Blood group incompatibility is a risk factor for type 1 diabetes...
  33. ncbi Improved graft survival in ABO-incompatible living donor kidney transplantation
    S Kaihara
    Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Transplant Proc 37:1804-5. 2005
    ..We reviewed ABO-incompatible living donor kidney transplantations (LDKT) performed in our institute...
  34. ncbi Improved outcomes after ABO-incompatible living-donor kidney transplantation after 4 weeks of treatment with mycophenolate mofetil
    Makoto Mannami
    Department of Urology, Uwajima Tokushukai Hospital, 2 6 24 Sumiyoshi, Uwajima 798 0003, Japan
    Transplantation 79:1756-8. 2005
    ..The administration of MMF 4 weeks before kidney transplant effectively inhibits B-cell function, suggesting a potential role for MMF in the prevention of humoral rejection...
  35. ncbi Pediatric heart transplantation across ABO blood type barriers: a case study
    Rose J Rodriguez
    Children s Hospital of New York Presbyterian, New York, NY, USA
    Prog Transplant 15:161-5. 2005
    ..This article presents a case study of a neonate with congenital heart disease who underwent one of the first successful ABO-incompatible heart transplantations in the United States...
  36. doi Six consecutive cases of successful adult ABO-incompatible living donor liver transplantation: a proposal for grading the severity of antibody-mediated rejection
    Daisuke Morioka
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Transplantation 85:171-8. 2008
    ..The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed...
  37. ncbi Titres of alloantibodies against A and B blood types in non-pedigree domestic cats in Turkey: assessing the transfusion reaction risk
    Mehmet Gurkan
    Department of Surgery, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey
    J Feline Med Surg 7:301-5. 2005
    ..4% and premature red cell destruction in 83.3%. Transfusion of type A or B blood to type AB cats results in no apparent clinical transfusion reactions...
  38. ncbi Implementation of a Protocol for ABO-incompatible kidney transplantation--a three-center experience with 60 consecutive transplantations
    Gunnar Tyden
    Departments of Transplantation Surgery and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
    Transplantation 83:1153-5. 2007
    ..A new protocol for ABO-incompatible kidney transplantation has recently been introduced. We report here on the joint experience of the implementation in Stockholm and Uppsala, Sweden and Freiburg, Germany...
  39. ncbi Management of anti-allogeneic antibody elimination by apheresis in living donor liver transplantation
    Naoki Kawagishi
    Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Ther Apher Dial 11:319-24. 2007
    ....
  40. ncbi Lessons learned from ABO-incompatible living donor kidney transplantation: 20 years later
    Jean Paul Squifflet
    Department of Kidney and Pancreas Transplantation and Organ Procurement, Saint Luc Hospital, University of Louvain Medical School, 10 Hippocrate Avenue, B 1200 Brussels, Belgium
    Exp Clin Transplant 2:208-13. 2004
    ..As the procedure remains unchanged, it might be reserved to patients where cadaver graft could not be a valuable alternative, especially for recipients < 15 years of age with a living related ABO-incompatible donor...
  41. doi New choices for patients needing kidney transplantation across antibody barriers
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    J Ren Care 34:85-93. 2008
    ..It is likely that both schemes will complement each other and both are available in the United Kingdom...
  42. ncbi Reversibility from delayed hyperacute rejection in ABO-incompatible renal transplantation: histopathological findings of renal allograft biopsy
    K Sugiyama
    Department of Nephrology, Toho University Omori Hospital, Tokyo, Japan
    Transplant Proc 37:701-4. 2005
    ..However, there has been no clear definition of histpathological criteria for DHAR after ABO-incompatible kidney transplantation. The definition must prognosticate whether the rejection process is reversible...
  43. ncbi Potential approaches to prevent uncommon hemolytic side effects of AB0 antibodies in plasma derivatives
    Christoph Buchta
    Department Transfusion Medicine, University Clinic for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Biologicals 33:41-8. 2005
    ..For harmonization of standards for anti-A and anti-B in plasma-derived therapeutics the regulators and manufacturers will have to realistically deal with complex clinical, practical, and economic issues...
  44. ncbi Impact of recipient age on outcome of ABO-incompatible living-donor liver transplantation
    Hiroto Egawa
    Department of Transplantation Immunology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 77:403-11. 2004
    ..The aim of the present study was to evaluate the outcome of liver transplants performed with ABO-incompatible living-donor livers and to detect risk factors for development of complications...
  45. ncbi First two AB-incompatible living kidney transplantations in the Balkans--should it be a procedure of choice in a developing country?
    G B Spasovski
    Department of Nephrology, University Clinical Center, University of Skopje, Macedonia
    Int J Artif Organs 30:173-5. 2007
    ....
  46. ncbi The Dutch national living donor kidney exchange program
    Marry de Klerk
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Transplant 5:2302-5. 2005
    ..For optimal results, both ABO blood type incompatible and cross match positive pairs should participate...
  47. doi Current status of liver transplantation across ABO blood-type barrier
    Hiroto Egawa
    Organ Transplant Unit, Kyoto University Hospital, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatobiliary Pancreat Surg 15:131-8. 2008
    ..The outcome is now similar to that of blood-type-matched transplantation. However, there are still issues to be solved in order to further improve the outcome via a decrease of infection...
  48. ncbi Complications, resource utilization, and cost of ABO-incompatible living donor kidney transplantation
    Jason Schwartz
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 82:155-63. 2006
    ..These protocols lead to an increase in resource utilization and cost of transplantation and may result in increased complications...
  49. ncbi Histologic findings one year after positive crossmatch or ABO blood group incompatible living donor kidney transplantation
    J M Gloor
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Transplant 6:1841-7. 2006
    ..Thus, although HR is associated with an increase in TG, in its absence allograft histology is similar in +XM, ABOI and conventional allografts 1 year posttransplant...
  50. ncbi ABO-incompatible live donor renal transplantation using blood group A/B carbohydrate antigen immunoadsorption and anti-CD20 antibody treatment
    Gunnela Nordén
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Xenotransplantation 13:148-53. 2006
    ..No splenectomy was performed. Eight recipients received one dose of anti-CD20 mAb (rituximab, 375 mg/m2) pre-operatively and 11 recipients had postoperative protocol IA...
  51. doi ABO incompatible renal transplantation in an HIV-seropositive patient
    Maya Campara
    Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, USA
    Transplantation 86:176-8. 2008
    ..Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/microL...
  52. doi Exchange living-donor kidney transplantation: merits and limitations
    Kyu Ha Huh
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 86:430-5. 2008
    ..After the success of the direct exchange donor (swap) program in Korea since 1991, we have developed a swap-around program. However, reports on the long-term outcomes of exchange donor programs are scarce...
  53. doi Application of flow cytometry to monitor antibody levels in ABO incompatible kidney transplantation
    Nithya S Krishnan
    Renal Department, University Hospitals Coventry and Warwickshire NHS Trust, United Kingdom
    Transplantation 86:474-7. 2008
    ..The method allowed quantitative discrimination in the range of antibody levels relevant to ABO incompatible transplantation and has the advantages over HA of objective measurement and reproducibility...
  54. ncbi Blood group antibodies and their significance in transfusion medicine
    Joyce Poole
    International Blood Group Reference Laboratory, Bristol, UK
    Transfus Med Rev 21:58-71. 2007
    ..However, deciding on the clinical significance of an antibody when compatible blood is not immediately available is likely to remain as one of the most common dilemmas facing transfusion practitioners...
  55. ncbi [Current status and future perspectives of living kidney transplantation from ABO-incompatible or spousal donors]
    Kazunari Tanabe
    Department of Urology, Graduate School of Medicine, Tokyo Women s Medical School, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 106:659-62. 2005
  56. ncbi Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression
    Hiroaki Shimmura
    Department of Urology, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Transplantation 80:985-8. 2005
    ..In conclusion, no correlation between anti-A/B antibody titers and the results of ABO-incompatible LKT was seen after tacrolimus or mycophenolate mofetil application...
  57. ncbi Safety and impact of donor-type red blood cell transfusion before allogeneic peripheral blood progenitor cell transplantation with major ABO mismatch
    Sebastian Scholl
    Department of Internal Medicine II, Oncology and Hematology, Friedrich Schiller University, Jena, Germany
    Transfusion 45:1676-83. 2005
    ..Major ABO mismatch can lead to different clinical problems including acute hemolysis after infusion of the allograft, delay of red blood cell (RBC) engraftment, or even manifestation of pure red cell aplasia (PRCA)...
  58. doi Results of kidney transplantation from ABO-incompatible living donors in a single institution
    T Kenmochi
    Department of Surgery, Chiba East National Hospital, National Hospital Organization, Chiba, Japan
    Transplant Proc 40:2289-91. 2008
    ..8%). Total patient survival at 3 years was 95.2%, and graft survival at 3 years was 90.5%, which were almost equal to those in the patients who underwent ABO-matched, compatible kidney transplantation...
  59. doi Transplantation of ABO-incompatible and living unrelated donor-recipient combinations
    N Ishikawa
    Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University School of Medicine, Tochigi, Japan
    Transplant Proc 40:2292-3. 2008
    ..9%) kidneys were donated from spouses (husband/wife) and 174 (20.9%) from ABO-incompatible donors. This study summarized our experience of ABO-incompatible and living unrelated, especially spousal kidney transplantation...
  60. ncbi Evaluation of immunosuppressive regimens in ABO-incompatible living kidney transplantation--single center analysis
    H Ishida
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Transplant 7:825-31. 2007
    ..001). We conclude that the FK/MMF combination regimen provides excellent graft survival results in ABO-ILKT...
  61. ncbi Steroid avoidance: is it ready for prime time?
    Martin L Mai
    Transplantation 86:897-8. 2008
  62. ncbi Five years of single-center experience with paired kidney exchange transplantation
    M Lucan
    Clinical Institute of Urology and Renal Transplantation, 4 6 Clinicilor Str, 400006 Cluj Napoca, Romania
    Transplant Proc 39:1371-5. 2007
    ..Even if there are still some unanswered questions, this program is current in some centers, and there appears to be a tendency to extend it in Europe. The aim of our study was to assess our results with PKEP after 5 years...
  63. ncbi [Diego blood system and the antibodies]
    Hatsue Tsuneyama
    Japanese Red Cross Tokyo Blood Center
    Nihon Rinsho 63:692-4. 2005
  64. ncbi ABO-incompatible transplantation--a safe way to perform renal transplantation?
    Jorg Beimler
    Nierenzentrum Heidelberg, Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:25-7. 2007
  65. ncbi Impact of HLA-identity on results of ABO-incompatible living kidney transplantation
    H Shimmura
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2172-4. 2004
    ..However, the impact on HLA-identity on the results of ABO-incompatible living donor kidney transplantation had not been investigated previously...
  66. ncbi [ABO-incompatible renal transplantation]
    Kazunari Tanabe
    Nihon Jinzo Gakkai Shi 46:411-8. 2004
  67. ncbi Impact of selected factors on early graft function in patients after renal transplantation
    J Sienko
    Department of Surgery and Transplantation, Pomeranian University of Medicine, Szczecin, Poland
    Transplant Proc 35:2167-9. 2003
    ..The study showed that a high maximal PRA level, incompatibility for ABO group, and a longer warm ischemia time increase the probability of early graft function disorders...
  68. ncbi ABO-mismatched platelet transfusions and clinical outcomes after cardiac surgery
    Neil Blumberg
    Transfusion 42:1527-8; author reply 1528-9. 2002
  69. ncbi Anti-Vel reactivity diminished by adsorption with rabbit RBC stroma
    Steven A Mechanic
    Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, Pennsylvania, USA
    Transfusion 42:1180-3. 2002
    ..Anti-Vel is an antibody to an antigen of high prevalence...
  70. ncbi Beneficial effect of antibody removal and enhanced immuno suppression in flow cytometry cross match-positive and ABO-incompatible renal transplantation
    A Katayama
    Kidney Center, Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Transplant Proc 34:2771-2. 2002
  71. ncbi Short-term results in ABO-incompatible living related kidney transplantation
    T Kawase
    Department of Surgery, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 34:2773. 2002
  72. ncbi Minor ABO-incompatible living-related lung transplantation
    Y Sano
    Department of Surgery II, Okayama University Medical School, Okayama, Japan
    Transplant Proc 34:2807-9. 2002
  73. ncbi The risk of transfusion to the wrong patient in Germany
    Gregor Caspari
    Transfusion 42:1238-9. 2002
  74. ncbi Expanding the living organ donor pool: positive crossmatch and ABO incompatible renal transplantation
    Mary Jo Holechek
    Adult Abdominal Organ Transplant Service, Johns Hopkins Hospital, Baltimore, MD, USA
    Nephrol Nurs J 30:195-204. 2003
    ..Many patients have willing live donors who are excluded from donation due to a positive crossmatch or blood group incompatibility. Plasmapheresis and intravenous immunoglobulin in combination can efficiently remove antibodies against ..
  75. ncbi Double filtration plasmapheresis in an ABO-incompatible renal transplantation: a case report
    H Kawamura
    Department of Urology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Transplant Proc 35:227-9. 2003
  76. ncbi The impact of delayed graft function on graft survival in living donor kidney transplantation
    O J Kwon
    Transplantation Unit, Hanyang University Hospital, Seoul, South Korea
    Transplant Proc 35:92-3. 2003
  77. ncbi Putative antibody-mediated rejection with C4d deposition in HLA-identical, ABO-compatible renal allografts
    A B Collins
    Department of Pathology, Medical and Surgical Services of Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Transplant Proc 38:3427-9. 2006
    ..This may account for some of the HLA antibody negative cases that develop antibody-mediated rejection...
  78. ncbi Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions
    Banu Aygun
    Division of Pediatric Hematology Oncology, Schneider Children s Hospital, New Hyde Park, NY, USA
    Transfusion 42:37-43. 2002
    ....
  79. ncbi Impact of positive PRA on the results of ABO-incompatible kidney transplantation
    H Shimmura
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2169-71. 2004
    ..It is well known that highly sensitized patients with positive panel reactive antibodies (PRA) often present with acute rejection. Therefore, we examined the impact of a positive PRA on the results of ABO-incompatible LKT...
  80. ncbi Absence of D- alloimmunization in AIDS patients receiving D-mismatched RBCs
    Fouad N Boctor
    Department of Pathology, Blood Bank and Transfusion Service, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Transfusion 43:173-6. 2003
    ..D- patients with AIDS may require blood transfusion and, during times of blood shortage, may receive D+ RBCs. They would be expected to become alloimmunized to the d antigen...
  81. ncbi Donor anti-Jk(a) causing hemolysis in a liver transplant recipient
    Mara Hareuveni
    Sourasky Medical Center, Tel Aviv, Israel
    Transfusion 42:363-7. 2002
    ..Passenger lymphocyte syndrome occurs when immunocompetent donor lymphocytes transferred during transplantation produce alloantibodies against host antigens...
  82. ncbi Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant
    Mark K Fung
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Transfusion 44:1635-9. 2004
    ..Approximately 10 percent of ABO-compatible liver transplants involve a D- donor and a D+ recipient...
  83. ncbi Predicting the effect of transfusing only phenotype-matched RBCs to patients with sickle cell disease: theoretical and practical implications
    Oswaldo Castro
    Department of Internal Meidicine, Howard University College of Medicine, Washington, DC, USA
    Transfusion 42:684-90. 2002
    ..Transfusing only phenotype-matched RBCs has been recommended to reduce the incidence of alloimmunization to blood group antigens in patients with sickle cell disease (SCD)...
  84. ncbi Therapeutic apheresis therapy for ABO-incompatible renal transplantations
    Hideki Ishida
    Department of Urology, Division of Blood Purification, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 7:520-8. 2003
    ..In this article, we describe the historical background, the current therapeutic strategies including apheresis therapy for the ABO-incompatible transplantations, and the experiences at our institution...
  85. ncbi Hydrops foetalis caused by anti-Mur in first pregnancy--a case report
    K H Wu
    China Medical College Hospital, Taichung, Taiwan
    Transfus Med 12:325-7. 2002
    ..The polymerase chain reaction-restriction fragment length polymorphism method confirmed that both the baby and her father had the Mi.III gene. Therefore, our report documents that anti-Mur has the potential to cause hydrops foetalis...
  86. ncbi Excellent long-term outcome of ABO-incompatible living donor kidney transplantation in Japan
    Kota Takahashi
    Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Am J Transplant 4:1089-96. 2004
    ..We conclude that long-term outcome in recipients of ABO-incompatible living kidneys is excellent. Transplantation of ABO-incompatible kidneys from living donors is a radical, but effective treatment for end-stage renal disease...
  87. ncbi Successful renal transplantation across simultaneous ABO incompatible and positive crossmatch barriers
    Daniel S Warren
    The Department of Surgery, The Johns Hopkins University School of Medicine, Balitmore, Maryland, USA
    Am J Transplant 4:561-8. 2004
    ..The ability to cross these two barriers simultaneously is clinically important as sensitized patients have often exhausted their blood type compatible living donors during previous transplants...
  88. ncbi An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility
    S Umit Sarici
    Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine Ihsan Doğramaci Children s Hospital, Ankara, Turkey
    Pediatrics 109:e53. 2002
    ....
  89. ncbi Bilirubin dosage in cord blood: could it predict neonatal hyperbilirubinemia?
    Adélia Jeha Nasser Bernaldo
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Sao Paulo Med J 122:99-103. 2004
    ..With early discharge, many newborns have to be readmitted to hospital for hyperbilirubinemia to be treated, and this has been held responsible for the reappearance of kernicterus...
  90. ncbi Neonatal anemia associated with Southeast Asian ovalocytosis
    Vichai Laosombat
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand
    Int J Hematol 82:201-5. 2005
    ..were premature infants, an infant with congenital syphilis, low-birth-weight infants, infants with ABO blood group incompatibility, infants with 3-thalassemia, infants with hemoglobin E heterozygote or homozygotes, glucose-6-phosphate ..
  91. ncbi ABO incompatible kidney transplantation - an analysis of UNOS Registry data
    Yasuro Futagawa
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Clin Transplant 20:122-6. 2006
    ..However, there are few reports to support the feasibility of ABO incompatible transplants from non-A2 deceased donors. This problem was examined in the United Network for Organ Sharing (UNOS) data file...
  92. ncbi Time-dependent risk factors influencing the long-term outcome in living renal allografts: donor age is a crucial risk factor for long-term graft survival more than 5 years after transplantation
    H Toma
    Department of Urology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, 162 8666 Japan
    Transplantation 72:940-7. 2001
    ..Most investigations have revealed that the improvement in early graft survival has not resulted in a corresponding improvement in long-term graft survival. The risk factors for long-term graft survival should be clarified...
  93. ncbi Distinguishing between recurrent primary sclerosing cholangitis and chronic rejection
    Anthony Jake Demetris
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Liver Transpl 12:S68-72. 2006
    ..Technical problems with biliary reconstruction, long cold ischemic times, non-heart beating donors, ABO blood group incompatibility, antibody-mediated rejection, and small-for-size syndrome in reduced-size or living donor livers can ..
  94. ncbi [Therapeutic apheresis: selective methods]
    Petar Kes
    Zavod za dijalizu, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska
    Acta Med Croatica 62:49-59. 2008
    ..They are useful in renal transplantation for cases with positive crossmatch or AB0 blood group incompatibility, as well as for treatment of acute humoral rejection...
  95. doi Factors related to the durability of a homograft monocusp valve inserted during repair of tetralogy of Fallot as based on the mid- to long-term outcomes
    Ji Hyuk Yang
    Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Cardiol Young 18:141-6. 2008
    ..In this study, we have evaluated the mid- to long-term outcomes, aiming to determine the durability of the homograft...
  96. ncbi Intrahepatic cholestasis after liver transplantation
    Ziv Ben-Ari
    Liver Institute and Department of Medicine D, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Liver Transpl 9:1005-18. 2003
    ..for hepatotoxicity, intrahepatic biliary strictures, chronic rejection, hepatic artery thrombosis, ABO blood group incompatibility, and recurrent disease...
  97. ncbi Development of non-ABO RBC alloantibodies in patients undergoing allogeneic HPC transplantation. Is ABO incompatibility a predisposing factor?
    J de la Rubia
    Department of Hematology, La Fe University Hospital, Valencia, Spain
    Transfusion 41:106-10. 2001
    ..Data from the appearance of RBC antibodies other than ABO in patients undergoing HPC transplantation are limited...
  98. ncbi Congenital haemolytic anaemia in a low birth weight infant due to congenital stomatocytosis
    P S Huppi
    Department of Obstetrics and Gynaecology, University of Berne, Switzerland
    Eur J Haematol 47:1-9. 1991
    ..There was no blood group incompatibility between mother and child but there was a marked stomatocytosis of the baby's red blood cells...
  99. ncbi Immune hemolysis associated with transplantation
    Lawrence D Petz
    StemCyte International Cord Blood Center, Arcadia, CA 91007, USA
    Semin Hematol 42:145-55. 2005
    ..One of the important causes is the passenger lymphocyte syndrome, which occurs following minor ABO blood group incompatibility between donor and recipient...
  100. doi Cell-free fetal DNA in the maternal serum and plasma: current and evolving applications
    Neil D Avent
    Centre for Research in Biomedicine, University of West of England, Bristol, UK
    Curr Opin Obstet Gynecol 21:175-9. 2009
    ..from maternal plasma for a number of clinical complications of pregnancy, notably feto-maternal blood group incompatibility, fetal sexing and exclusion/detection of single-gene disorders...
  101. ncbi A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy
    Ozmert M A Ozdemir
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Turk J Pediatr 50:592-4. 2008
    ..newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported...

Research Grants105 found, 100 shown here

  1. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2010
    ..the transplantation of kidneys from living donors who otherwise are not transplanted because of ABO blood group incompatibility and/or the presence of donor-specific antibodies (Abs;DSA) in sensitized patients...
  2. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  3. Erythrocyte Complement Receptor 1 in Transfusion/Malaria
    Karina Yazdanbakhsh; Fiscal Year: 2005
    ....
  4. Immunoregulatory responses in patients with ITP
    Karina Yazdanbakhsh; Fiscal Year: 2009
    ..We believe that understanding how the immune cells are affected by the drugs will provide the breakthrough knowledge that helps us cure all ITP patients. (End of Abstract) ..
  5. Immunoregulatory responses in patients with ITP
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..We believe that understanding how the immune cells are affected by the drugs will provide the breakthrough knowledge that helps us cure all ITP patients. (End of Abstract) ..
  6. Studies of rHuTPO in ITP and of rVlla in Liver Disease
    David Kuter; Fiscal Year: 2006
    ..Study endpoints would include (a) the percentage of patients increasing the platelet count over 50x109/L, (b) the number of RBC and platelet transfusions at splenectomy, (c) the rate of adverse events. ..
  7. Pediatric Transfusion Medicine Academic Career Award
    CASSANDRA JOSEPHSON; Fiscal Year: 2007
    ..End of Abstract) ..
  8. Genetics of Anorexia Nervosa
    Bernie Devlin; Fiscal Year: 2006
    ..The diagnostic and genetic data and lymphoblastoid cell lines (derived from blood samples) will become part of a national archival resource for genetic studies of AN through the NIMH Genetics Initiative. ..
  9. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2006
    ..abstract_text> ..
  10. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2010
    ..Thus, the proposed studies are relevant to the treatment/cure of a variety of diseases involving blood cell production. ..
  11. Genetics of Schizophrenia in Oceanic Palau.
    Bernie Devlin; Fiscal Year: 2010
    ..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, the research team and the novelty of hypotheses and approach. ..
  12. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  13. GENETIC ASSOCIATION IN SCHIZOPHRENIA AND OTHER DISORDERS
    Bernie Devlin; Fiscal Year: 2010
    ..To accomplish this goal, researchers need the right tools;our research group seeks to develop the required statistical tools. ..
  14. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2010
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  15. Genomic Approaches to Improve Transfusion Therapy in SCD Patients
    Marion E Reid; Fiscal Year: 2010
    ..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
  16. Transfusion Infection Pediatric Prospective Study (TRIPPS)
    NAOMI L LUBAN; Fiscal Year: 2010
    ..This application focuses on infants and children, a vulnerable and heretofore poorly studied recipient group. ..
  17. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  18. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2006
    ..abstract_text> ..
  19. Genomic Approaches to Improve Transfusion Therapy in SCD Patients
    Marion Reid; Fiscal Year: 2007
    ..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
  20. Transfusion Infection Pediatric Prospective Study (TRIPPS)
    Naomi Luban; Fiscal Year: 2007
    ..This application focuses on infants and children, a vulnerable and heretofore poorly studied recipient group. ..
  21. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
    ..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
  22. Transfusion Medicine/Hemostasis Clinical Research Network
    Darrell Triulzi; Fiscal Year: 2007
    ..university of pittsburgh critiques ..
  23. JHMI Core Clinical Center for TMHCTN
    Paul Ness; Fiscal Year: 2007
    ..We have also contributed a number of publications attributed to our JHMI authors and the TMH CTN. JOHNS HOPKINS UNIVERSITY CRITIQUES ..
  24. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. ..
  25. TRANSFUSION MEDICINE RESEARCH TRAINING PROGRAM
    Donald Siegel; Fiscal Year: 2007
    ..The program's Director and Oversight Committee strive to design an educational experience tailored for each individual trainee. ..
  26. GENETIC ASSOCIATION IN SCHIZOPHRENIA AND OTHER DISORDERS
    Bernie Devlin; Fiscal Year: 2009
    ..To accomplish this goal, researchers need the right tools; our research group seeks to develop the required statistical tools. ..
  27. GENETIC ASSOCIATION IN SCHIZOPHRENIA AND OTHER DISORDERS
    Bernie Devlin; Fiscal Year: 2002
    ..We plan to apply these methods to data on three psychiatric disorders, namely schizophrenia, attention deficit/ hyperactivity disorder, and Alzheimer's disease, as well as to data on simple genetic disorders. ..
  28. PCR Screening for CMV in Umbilical Cord Blood Stem Cells
    Christopher Hillyer; Fiscal Year: 2003
    ....
  29. RH PROTEIN AND THE RH BLOOD GROUP SYSTEM
    Chen Han Huang; Fiscal Year: 2004
    ..The knowledge gained will also deepen our understanding of clinical problems associated with the RH blood group system, allowing the clinical service to explore new approaches for their management. ..
  30. TRANSFUSION TRANSMISSION OF CELL-ASSOCIATED INFECTIONS
    Christopher Hillyer; Fiscal Year: 2003
    ..He predicts that allogeneic leukocyte interactions mediate reactivation of MCMV in the recipient and that g IFN inhibits this process. ..
  31. MONOCLONAL ITP AUTOANTIBODIES--PARADIGM FOR AUTOIMMUNITY
    Donald Siegel; Fiscal Year: 2002
    ..Ultimately, the proposed approach may be applied to the understanding of other autoimmune disorders. ..
  32. Transfusion Infections Pedi Prospective Study (TRIPPS)
    Naomi Luban; Fiscal Year: 2005
    ....
  33. Transfusion Infection Pediatric Prospective Study (TRIPPS)
    Naomi Luban; Fiscal Year: 2009
    ..This application focuses on infants and children, a vulnerable and heretofore poorly studied recipient group. ..
  34. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  35. REPORTING SYSTEM TO IMPROVE SAFETY OF THE BLOOD SUPPLY
    Harold Kaplan; Fiscal Year: 2002
    ..The validation and continued operation of MERS-TM is an appropriate response to the public's interest and to meet the needs of transfusion medicine. ..
  36. GENETIC ASSOCIATION IN SCHIZOPHRENIA AND OTHER DISORDERS
    Bernie Devlin; Fiscal Year: 2007
    ..Therefore we propose to study its properties. We also propose refinement to models for admixture mapping that account for uncertainty in ancestral allele distributions and dependent markers. ..
  37. RhBG and RhcG Proteins in Nonerythroid Tissues
    Chen Han Huang; Fiscal Year: 2005
    ..The results obtained should contribute to understanding the structure, function and regulation of the Rh family, revealing a potentially important, new homeostatic mechanism operative in human and mammalian organs. ..
  38. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  39. Phage Display Tools for Automated Blood Typing
    Donald Siegel; Fiscal Year: 2007
    ....
  40. Admixture Mapping Schizophrenia Genes in Oceanic Palau
    Bernie Devlin; Fiscal Year: 2006
    ..Collaborating sites are the University of Pittsburgh (Devlin), Carnegie Mellon University (Roeder, subcontract to Pitt) and University of California Irvine (Byerley). ..