bullous pemphigoid

Summary

Summary: A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.

Top Publications

  1. doi Bullous pemphigoid: a prototypical antibody-mediated organ-specific autoimmune disease
    Cassian Sitaru
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    J Invest Dermatol 129:822-4. 2009
  2. ncbi Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230
    Maria Kiss
    Department of Dermatology and Allergology, University of Szeged, H 6720 Szeged, Koranyi fasor 6, Hungary
    J Autoimmun 24:1-10. 2005
  3. doi Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid
    Giovanni Di Zenzo
    Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    Clin Immunol 128:415-26. 2008
  4. ncbi Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
    L Guo
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Cell 81:233-43. 1995
  5. ncbi Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid
    Yukiko Tsuji-Abe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    J Dermatol Sci 37:145-9. 2005
  6. ncbi Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
    G J Giudice
    Department of Dermatology, Medical College of Wisconsin, Milwaukee
    J Invest Dermatol 99:243-50. 1992
  7. ncbi Humanization of autoantigen
    Wataru Nishie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nat Med 13:378-83. 2007
  8. ncbi Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin
    Cassian Sitaru
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 118:664-71. 2002
  9. pmc Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Autoimmun 31:331-8. 2008
  10. ncbi BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid
    Masakazu Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 30:224-32. 2002

Research Grants

  1. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2010
  2. PEMPHIGUS AND PEMPHIGOID
    Luis Diaz; Fiscal Year: 2005
  3. Mechanism of neurodegeneration in dystonia musculorum
    RONALD LIEM; Fiscal Year: 2007
  4. Complement Anaphylatoxin Receptors in Inflammation
    RICK WETSEL; Fiscal Year: 2005
  5. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2007
  6. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard S Blumberg; Fiscal Year: 2010
  7. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2009
  8. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 1990
  9. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
  10. HEMIDESMOSOMES IN BULLOUS PEMPHIGOID
    GEORGE GIUDICE; Fiscal Year: 2007

Detail Information

Publications261 found, 100 shown here

  1. doi Bullous pemphigoid: a prototypical antibody-mediated organ-specific autoimmune disease
    Cassian Sitaru
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    J Invest Dermatol 129:822-4. 2009
    b>Bullous pemphigoid (BP) is a prototypical organ-specific autoimmune disease. Autoantibodies unfold their blister-inducing potential by triggering an Fcgamma-dependent inflammatory reaction. The study by Iwata et al...
  2. ncbi Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230
    Maria Kiss
    Department of Dermatology and Allergology, University of Szeged, H 6720 Szeged, Koranyi fasor 6, Hungary
    J Autoimmun 24:1-10. 2005
    b>Bullous pemphigoid (BP) is an IgG-mediated autoimmune blistering disease that targets the hemidesmosomal proteins BP230 and BP180...
  3. doi Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid
    Giovanni Di Zenzo
    Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    Clin Immunol 128:415-26. 2008
    b>Bullous pemphigoid (BP) is an autoimmune bullous disease, associated with autoantibodies directed against the hemidesmosomal components BP180 and BP230...
  4. ncbi Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
    L Guo
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Cell 81:233-43. 1995
    BPAG1 is the major antigenic determinant of autoimmune sera of bullous pemphigoid (BP) patients...
  5. ncbi Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid
    Yukiko Tsuji-Abe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    J Dermatol Sci 37:145-9. 2005
    ..by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP)...
  6. ncbi Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
    G J Giudice
    Department of Dermatology, Medical College of Wisconsin, Milwaukee
    J Invest Dermatol 99:243-50. 1992
    b>Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the presence of subepidermal blisters resulting from a disruption of the adhesive interactions between basal keratinocytes and the cutaneous basement membrane...
  7. ncbi Humanization of autoantigen
    Wataru Nishie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nat Med 13:378-83. 2007
    ..Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect ..
  8. ncbi Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin
    Cassian Sitaru
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 118:664-71. 2002
    b>Bullous pemphigoid is a subepidermal autoimmune blistering disease associated with autoantibodies to the hemidesmosomal bullous pemphigoid antigens 180 and 230...
  9. pmc Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Autoimmun 31:331-8. 2008
    b>Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome...
  10. ncbi BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid
    Masakazu Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 30:224-32. 2002
    b>Bullous pemphigoid (BP) is an acquired autoimmune subepidermal blistering disease against hemidesmosomal cytoplasmic BP230 and transmembrane BP180 proteins...
  11. pmc Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
    Lisa Leighty
    Department of Dermatology, University of North Carolina School of Medicine, 3100 Thurston Bowles, Chapel Hill, NC 27599, USA
    Arch Dermatol Res 299:417-22. 2007
    b>Bullous pemphigoid (BP) is a subepidermal skin blistering disease characterized immunohistologically by dermal-epidermal junction (DEJ) separation, an inflammatory cell infiltrate in the upper dermis, and autoantibodies targeted toward ..
  12. doi Anti-bullous pemphigoid 180 and 230 antibodies in a sample of unaffected subjects
    Carilyn N Wieland
    Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Dermatol 146:21-5. 2010
    To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP.
  13. doi A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study
    Pascal Joly
    Department of Dermatology, INSERM U901, University of Rouen, Rouen, France
    J Invest Dermatol 129:1681-7. 2009
    Superpotent topical corticosteroids (CS) have been demonstrated to improve bullous pemphigoid (BP) patients' survival...
  14. doi Evaluation of a new ELISA assay for detection of BP230 autoantibodies in bullous pemphigoid
    Marilina Tampoia
    Clinical Pathology Laboratory, Polyclinic of Bari, Bari, Italy
    Ann N Y Acad Sci 1173:15-20. 2009
    The diagnosis of bullous pemphigoid is based on clinical observations and on the presence of autoantibodies directed against proteins of the dermoepidermal junction...
  15. ncbi Bullous pemphigoid: end of the century overview
    Z Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
    J Dermatol 28:647-50. 2001
    b>Bullous pemphigoid (BP) was first described by Lever in 1953 as a subepidermal blistering disease...
  16. pmc A major role for neutrophils in experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 100:1256-63. 1997
    b>Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein, BP180...
  17. ncbi Cloning of hamster type XVII collagen cDNA, and pathogenesis of anti-type XVII collagen antibody and complement in hamster bullous pemphigoid
    Katsushi Yamamoto
    Division of Oncology and Biology, Genome Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Invest Dermatol 118:485-92. 2002
    b>Bullous pemphigoid is an inflammatory subepidermal blistering skin disease associated with an IgG autoimmune response to the type XVII collagen...
  18. ncbi The pathophysiology of bullous pemphigoid
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Clin Rev Allergy Immunol 33:67-77. 2007
    b>Bullous pemphigoid (BP) is a blistering skin disease characterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal-epidermal junction, designated BP180 and BP230...
  19. ncbi Multiple sclerosis and bullous pemphigoid: a casual association or a pathogenetic correlation?
    Giuseppe Stinco
    Institute of Dermatology, Department of Clinical and Experimental Pathology and Medicine, University of Udine, Gemona Hospital, Via Battiferro, 1, 33123 Gemona del Friuli Ud, Italy
    Eur J Dermatol 12:186-8. 2002
    The literature reports about thirty cases of bullous pemphigoid (BP) which developed in patients affected by multiple sclerosis (MS), although a relationship between these two diseases has not yet been identified...
  20. ncbi A retrospective epidemiological study on the association of bullous pemphigoid and neurological diseases
    Giuseppe Stinco
    Department of Clinical and Experimental Pathology and Medicine, DPMSC Institute of Dermatology, University of Udine, 33013 Gemona del Friuli, Italy
    Acta Derm Venereol 85:136-9. 2005
    b>Bullous pemphigoid is a rare chronic recurrent dermatosis that is often reported in association with various neurological diseases...
  21. pmc Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies
    J R Stanley
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892
    J Clin Invest 82:1864-70. 1988
    Autoantibodies from bullous pemphigoid (BP) patients define a 230-kD protein found in the basement membrane of stratified squamous epithelia...
  22. doi Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study
    G Marazza
    Service de Dermatologie, Hopitaux Universitaires de Geneve, 1211 Geneva 14, Switzerland
    Br J Dermatol 161:861-8. 2009
    b>Bullous pemphigoid (BP), pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune bullous diseases characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens ..
  23. ncbi Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly
    Jan Koster
    The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 116:387-99. 2003
    ..The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only to BP230, but also to plectin...
  24. ncbi Bullous pemphigoid in a leg affected with hemiparesia: a possible relation of neurological diseases with bullous pemphigoid?
    N Foureur
    Department of Dermatology, Bichat Claude Bernard Hospital, 46, rue Henri Huchard 75018 Paris, France
    Eur J Dermatol 11:230-3. 2001
    We report a typical case of bullous pemphigoid (BP) associated with a neurological disorder and study a possible link between neurological disorders and BP...
  25. pmc Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
    S B Hopkinson
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Cell Biol 130:117-25. 1995
    The 180-kD bullous pemphigoid autoantigen (BP180) is a component of the hemidesmosome, a cell-matrix connector...
  26. pmc Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study
    S M Langan
    Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    BMJ 337:a180. 2008
    To determine the incidence of and mortality from bullous pemphigoid and pemphigus vulgaris in the United Kingdom.
  27. doi Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid
    Suying Feng
    Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China
    Int J Dermatol 47:225-8. 2008
    The 180-kDa transmembrane hemidesmosomal protein (BPAG2) has been identified as an important autoantigen in bullous pemphigoid (BP)...
  28. doi A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen
    Hideyuki Ujiie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Immunol 184:2166-74. 2010
    b>Bullous pemphigoid (BP), the most common autoimmune blistering disease, is caused by autoantibodies against type XVII collagen (COL17)...
  29. ncbi Bullous pemphigoid antigen 1 isoforms: potential new target autoantigens in multiple sclerosis?
    E Laffitte
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Br J Dermatol 152:537-40. 2005
    The simultaneous occurrence of bullous pemphigoid (BP) and multiple sclerosis (MS), two autoimmune diseases involving the skin and the central nervous system (CNS), respectively, has been described.
  30. ncbi Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid
    Mariko Yoshida
    Department of Dermatology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Dermatol Sci 41:21-30. 2006
    By immunoblot analyses of normal human epidermal extracts, the 230kDa bullous pemphigoid antigen (BP230) is recognized by most bullous pemphigoid (BP) sera...
  31. pmc Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid
    R Chen
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Invest 108:1151-8. 2001
    b>Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein BP180...
  32. pmc The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles
    C L Leung
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cell Biol 154:691-7. 2001
    b>Bullous pemphigoid antigen 1 (BPAG1) is a member of the plakin family with cytoskeletal linker properties. Mutations in BPAG1 cause sensory neuron degeneration and skin fragility in mice...
  33. ncbi Oral lesions in patients with pemphigus vulgaris and bullous pemphigoid
    Jozo Budimir
    School of Dental Medicine, University of Zagreb, Croatia
    Acta Clin Croat 47:13-8. 2008
    ..onset of symptoms and therapy between patients with pemphigus vulgaris and those suffering from bullous pemphigoid. Based on clinical presentation, histopathologic analysis, direct and indirect immunofluorescence, Tzanck ..
  34. ncbi Hemidesmosomes: roles in adhesion, signaling and human diseases
    L Borradori
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL 1066 CX, Amsterdam, The Netherlands
    Curr Opin Cell Biol 8:647-56. 1996
    ..These multiprotein complexes appear not only to mediate cell adhesion, but also to transduce signals from the extracellular matrix to the cell interior that may profoundly modulate cell behavior...
  35. ncbi Childhood bullous pemphigoid following hepatitis B immunization
    Zulal Erbagci
    Gaziantep University Medical Faculty, Department of Dermatology, Gaziantep, Turkey
    J Dermatol 29:781-5. 2002
    b>Bullous pemphigoid (BP) is an acquired autoimmune bullous disorder which predominantly affects the elderly. It is very rare in children. There are approximately 50 reported cases of childhood BP...
  36. doi IgG autoantibody reactivity against bullous pemphigoid (BP) 180 and BP230 in elderly patients with pruritic dermatoses
    C Feliciani
    Department of Dermatology and Allergology, Philipps University Marburg, 35039 Marburg, Germany
    Br J Dermatol 161:306-12. 2009
    ..Specifically, a prodromal phase of bullous pemphigoid (BP) has to be considered in patients with pruritic lesions of polymorphic appearance...
  37. ncbi Neurological disorders in patients with bullous pemphigoid
    Nadege Cordel
    Department of Dermatology, Pointe à Pitre University Hospital, Pointe a Pitre, Guadeloupe, Pointe A Pitre cedex, France
    Dermatology 215:187-91. 2007
    Unexpected cases of bullous pemphigoid (BP) have been reported in adult patients with various neurological disorders suggesting a possible relationship between these diseases.
  38. doi The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study
    Kathy Taghipour
    Department of Dermatology, Oxford Radcliffe Hospitals, Old Road, Headington, Oxford OX3 7LJ, England
    Arch Dermatol 146:1251-4. 2010
    To investigate the relationship between bullous pemphigoid (BP) and neurologic disease.
  39. ncbi BP230- and BP180-specific auto-antibodies in bullous pemphigoid
    Sybille Thoma-Uszynski
    Department of Dermatology, Friedrich Alexander University, Erlangen Nurnberg, Germany
    J Invest Dermatol 122:1413-22. 2004
    b>Bullous pemphigoid is a subepidermal blistering disease associated with auto-antibodies (auto-ab) to BP180 and BP230...
  40. doi Medication history of a series of patients with bullous pemphigoid from northern Greece - observations and discussion
    Aikaterini Patsatsi
    First Dermatologic Clinic and First Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Greece
    Int J Dermatol 48:132-5. 2009
    b>Bullous pemphigoid (BP) is an autoimmune bullous disease that mainly affects elderly patients...
  41. ncbi Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation
    Y Hirako
    Unit of Biosystems, Graduate School of Human Informatics, The Department of Molecular Biology, School of Science, Nagoya University, Chikusa ku, Nagoya 464 01, Japan
    J Biol Chem 271:13739-45. 1996
    The 180-kDa bullous pemphigoid antigen (BP180) is a hemidesmosomal transmembrane glycoprotein comprising interrupted collagen domains in its extracellular part. BP180 is also termed type XVII collagen...
  42. ncbi [Bullous pemphigoid in young patients: a retrospective study of 74 cases]
    E Bourdon-Lanoy
    Service de Dermatologie, Hopital Henri Mondor, 94010 Creteil, France
    Ann Dermatol Venereol 132:115-22. 2005
    b>Bullous pemphigoid usually affects elderly people. Only a few isolated cases among people younger than 65 years have been reported.
  43. ncbi Childhood bullous pemphigoid developed after the first vaccination
    C Baykal
    Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Turkey
    J Am Acad Dermatol 44:348-50. 2001
    b>Bullous pemphigoid (BP) typically affects the elderly. There are at least 40 reported cases of BP in childhood, 10 reported cases at 1 year of age or younger. The antigen of this autoimmune disease is localized to the hemidesmosome...
  44. doi Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladder
    Ayano Umekoji
    Department of Dermatology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    J Dermatol 37:251-4. 2010
    Skin disorders that appear in association with internal malignancies are called dermadromes. Bullous pemphigoid (BP), which is a major autoimmune disease of the skin, is considered to be a dermadrome, although there have been conflicting ..
  45. ncbi Autoantibodies to human alpha6 integrin in patients with bullous pemphigoid
    Maria Kiss
    Department of Dermatology and Allergology, University of Szeged, H 6720 Szeged, Koranyi fasor 6, Hungary
    Ann N Y Acad Sci 1051:104-10. 2005
    b>Bullous pemphigoid (BP) is characterized immunologically by tissue-bound and circulating autoantibodies targeting the hemidesmosomal proteins BP230 and BP180...
  46. ncbi A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading
    Janet A Fairley
    Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Am Acad Dermatol 51:118-22. 2004
    b>Bullous pemphigoid (BP) and epidermolysis bullosa acquisita are distinct autoimmune blistering disorders...
  47. ncbi Macrophage migration inhibitory factor (MIF) in bullous pemphigoid
    Yukie Asano
    J Dermatol Sci 49:95-7. 2008
  48. ncbi Pemphigus and bullous pemphigoid
    H C Nousari
    Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2196, USA
    Lancet 354:667-72. 1999
    Pemphigus and bullous pemphigoid are distinct autoimmune blistering diseases that are characterised by the presence of autoantibodies directed against specific adhesion molecules of the skin and mucous membranes...
  49. doi Serological studies in bullous pemphigoid: a literature review of antibody titers at presentation and in clinical remission
    Stefania Leuci
    Department of Odontostomatological and Maxillo Facial Sciences, Federico II University of Naples, Italy
    Acta Derm Venereol 90:115-21. 2010
    b>Bullous pemphigoid is associated with antibodies to a 230 kDa and a 180 kDa protein. In a literature review we investigated the role of auto-antibodies as detected by different serological assays...
  50. ncbi IgE antibodies in sera from patients with bullous pemphigoid are autoantibodies preferentially directed against the 230-kDa epidermal antigen (BP230)
    R F Ghohestani
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Clin Immunol 18:202-9. 1998
    b>Bullous pemphigoid (BP) is unique among autoimmune skin diseases in which a high serum IgE level has been detected...
  51. doi IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachment
    Hiroaki Iwata
    Department of Dermatology, Gifu Graduate School of Medicine, Gifu, Japan
    J Invest Dermatol 129:919-26. 2009
    We have shown that binding of bullous pemphigoid (BP)-patient IgG (BP-IgG) causes the internalization of BP180 from the cell membrane...
  52. ncbi The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression
    B Favre
    Department of Dermatology, University Medical School, 1211 Geneva 14, Switzerland
    J Biol Chem 276:32427-36. 2001
    The bullous pemphigoid antigen 1 (eBPAG1) is a constituent of hemidesmosomes (HDs), cell-substrate adhesion complexes in stratified epithelia...
  53. ncbi Development of a system for detection of circulating antibodies against hemidesmosomal proteins in patients with bullous pemphigoid
    S Husz
    Department of Dermatology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Arch Dermatol Res 292:217-24. 2000
    Specific antibodies directed against special hemidesmosomal proteins are involved in the pathogenesis of bullous pemphigoid (BP), and detection of these antibodies is crucial for a correct diagnosis...
  54. ncbi Furosemide-induced bullous pemphigoid: case report and review of literature
    Jennifer J Lee
    Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Drugs Dermatol 5:562-4. 2006
    b>Bullous pemphigoid (BP) is an acquired autoimmune disease characterized by subepidermal vesicles and bullae...
  55. ncbi Elevated levels of eotaxin and interleukin-5 in blister fluid of bullous pemphigoid: correlation with tissue eosinophilia
    M Wakugawa
    Department of Dermatology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Dermatol 143:112-6. 2000
    b>Bullous pemphigoid (BP) often provokes blood and tissue eosinophilia, which suggests that some chemoattractants modulate the eosinophil infiltration in BP...
  56. ncbi Furosemide-induced bullous pemphigoid
    K Baz
    J Eur Acad Dermatol Venereol 16:81-2. 2002
  57. ncbi A case of bullous pemphigoid arising in juvenile hyaline fibromatosis with oral squamous cell carcinoma
    Kazuhiro Shimizu
    Department of Dermatology, Nagasaki University, Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, 852 8501 Nagasaki, Japan
    J Dermatol 32:650-3. 2005
    We experienced a case of bullous pemphigoid (BP) arising in juvenile hyaline fibromatosis (JHF) associated with oral squamous cell carcinoma (SCC). JHF is a very rare disease inherited in an autosomal recessive fashion...
  58. ncbi A highly sensitive and simple assay for the detection of circulating autoantibodies against full-length bullous pemphigoid antigen 180
    Enno Schmidt
    Department of Biotechnology, Biocenter, University of Wurzburg, Wurzburg, Germany
    J Autoimmun 18:299-309. 2002
    b>Bullous pemphigoid antigen 180 (BP180) is the target of autoantibodies in various subepidermal blistering diseases. The most common one is bullous pemphigoid (BP)...
  59. ncbi Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid
    Nobuko Ishiura
    Department of Dermatology, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    J Dermatol Sci 49:153-61. 2008
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230...
  60. ncbi Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoid
    Alfred Goodfellow
    Department of Dermatology Department of Infectious Disease, Saint John Regional Hospital, Saint John, NB
    J Cutan Med Surg 13:280-2. 2009
    ..Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed...
  61. doi Activation of blood coagulation in bullous pemphigoid: role of eosinophils, and local and systemic implications
    A V Marzano
    Department of Internal Medicine, IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli, Regina Elena, Milan, Italy
    Br J Dermatol 160:266-72. 2009
    b>Bullous pemphigoid (BP) is a blistering skin disease caused by autoantibodies to hemidesmosomal proteins, with eosinophils participating in blister formation...
  62. ncbi Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris
    M J Rico
    Dermatology Service, New York VA Medical Center and Department of Dermatology, New York University, 423 East 23rd Street, New York, NY 10010, USA
    Br J Dermatol 140:1079-86. 1999
    ..cell marker expression in perilesional skin biopsies from patients with the autoimmune blistering diseases bullous pemphigoid (BP, n = 21) and pemphigus vulgaris (PV, n = 7)...
  63. pmc Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice
    Edit B Olasz
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Invest Dermatol 127:2807-17. 2007
    b>Bullous pemphigoid antigen 2 (BPAG2) is targeted by autoantibodies in patients with bullous pemphigoid (BP), and absent in patients with one type of epidermolysis bullosa (OMIM #226650)...
  64. ncbi A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice
    Janet A Fairley
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Invest Dermatol 127:2605-11. 2007
    b>Bullous pemphigoid (BP) is an autoimmune disease characterized by subepidermal blistering. Based on previous work, IgG autoantibodies directed against BP180 are thought to be the primary pathogenic agent in BP...
  65. doi Bullous pemphigoid autoantibodies preferentially recognize phosphoepitopes in collagen XVII
    Elena P Zimina
    J Invest Dermatol 128:2736-9. 2008
  66. doi Ectodomain shedding generates Neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoid
    Wataru Nishie
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    J Immunol 185:4938-47. 2010
    ..Correspondingly, neoepitopes were found in the skin and blister fluids of patients with bullous pemphigoid, and bullous pemphigoid sera reacted with the peptide Leu(524)-Gly(532)...
  67. pmc A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid
    Kelly A N Messingham
    The Department of Dermatology, University of Iowa, Iowa City, IA, USA
    J Immunol Methods 346:18-25. 2009
    b>Bullous pemphigoid (BP) is a humoral autoimmune disease directed predominantly against the non-collagenous NC16A domain of the BP180 hemidesmosomal protein...
  68. ncbi Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid
    Janet A Fairley
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Invest Dermatol 125:467-72. 2005
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal protein BP180 (BPAg2, type XVII collagen)...
  69. ncbi Minocycline as a therapeutic option in bullous pemphigoid
    W J Loo
    Department of Dermatology, The Churchill, Oxford Radcliffe Hospital, Headington, Oxford, UK
    Clin Exp Dermatol 26:376-9. 2001
    We present a retrospective analysis of patients with bullous pemphigoid (BP) treated with minocycline in the Department of Dermatology, Churchill Hospital, Oxford between July 1986 and May 2000...
  70. ncbi Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
    Y Hirako
    Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya 464 01
    J Biol Chem 273:9711-7. 1998
    ..One of the putative cell-matrix adhesion molecules present in the HD is the 180-kDa bullous pemphigoid antigen (BP180), also termed type XVII collagen...
  71. doi Bullous pemphigoid and related subepidermal autoimmune blistering diseases
    Edit B Olasz
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Dir Autoimmun 10:141-66. 2008
    The pemphigoid group of autoimmune blistering diseases includes distinct entities (bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis and lichen planus pemphigoides) that are characterized by ..
  72. ncbi The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1
    A Brown
    Institut du Cancer de Montreal, Centre de Recherche L C Simard, Quebec, Canada
    Nat Genet 10:301-6. 1995
    ..encodes an N-terminal actin binding domain and a C-terminal portion comprised of the hemidesmosomal protein, bullous pemphigoid antigen 1 (bpag1)...
  73. doi Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Arch Dermatol 144:41-8. 2008
    To determine the prevalence, immunoglobulin subclass distribution, and clinical correlation of antibodies (Abs), especially of IgE Abs, to BP180 and BP230 in patients with bullous pemphigoid (BP).
  74. ncbi Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation
    Ruoyan Chen
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:3987-92. 2002
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease associated with autoantibodies against two hemidesmosomal proteins, BP180 and BP230. Numerous inflammatory cells infiltrate the upper dermis in BP...
  75. ncbi Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen
    L S Chan
    Veterans Affairs Chicago Health Care System, Department of Dermatology, Northwestern University Medical School, Ill 60611 3010, USA
    Arch Dermatol 135:569-73. 1999
    ..Bullous systemic lupus erythematosus is a generalized subepidermal blistering skin eruption in patients suffering from systemic lupus erythematosus. Type VII collagen was initially identified as the target antigen...
  76. ncbi A predominant IgG4 subclass may be responsible for false-negative direct immunofluorescence in bullous pemphigoid
    Kerry E Buschman
    Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cutan Pathol 29:282-6. 2002
    b>Bullous pemphigoid (BP) is an immune-mediated blistering disease, usually characterized immunopathologically by the linear deposition of IgG and C3 along the basement membrane zone (BMZ) of skin...
  77. ncbi Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid
    Iakov Shimanovich
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Pathol 204:519-27. 2004
    Epidermolysis bullosa acquisita (EBA) and bullous pemphigoid (BP) are two clinically and immunologically distinct autoimmune subepidermal blistering skin diseases associated with IgG autoantibodies against the dermal-epidermal junction...
  78. doi Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence testing in a bullous pemphigoid and pemphigoid gestationis
    Maria A Barnadas
    Department of Dermatology, Hospital Sta Creu i St Pau, Barcelona, Spain
    Int J Dermatol 47:1245-9. 2008
    ..BP180-NC16a domain ELISA with that of an indirect immunofluorescence (IIF) testing in the evaluation of bullous pemphigoid (BP) and pemphigoid gestationis (PG), and analyzed the relationship between ELISA results and the presence ..
  79. ncbi Immunoglobulin G subclass distribution of bullous pemphigoid autoantibodies and complement fixation studies
    Khalid S Al-Karawi
    Department of Surgery, Dammam Central Hospital, Al Khobar 31952, Kingdom of Saudi Arabia
    Saudi Med J 23:1492-5. 2002
    ..immunoglobulin G (IgG) subclass distribution of tissue bound and circulating antibasement membrane zone antibodies in bullous pemphigoid. In addition, the complement fixing capability of circulating IgG subclasses was also investigated.
  80. ncbi Role of FcRs in animal model of autoimmune bullous pemphigoid
    Minglang Zhao
    Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    J Immunol 177:3398-405. 2006
    b>Bullous pemphigoid (BP) is a bullous dermatosis associated with autoantibodies directed against the hemidesmosomal Ags BP180 and BP230...
  81. ncbi A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex
    D F Mutasim
    J Invest Dermatol 84:47-53. 1985
    b>Bullous pemphigoid (BP) antibodies are known to react with an antigen of the basement membrane zone (BMZ) of squamous epithelia and produce, by the indirect immunofluorescence technique, linear fluorescence at the BMZ...
  82. pmc Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 43226, USA
    J Exp Med 186:777-83. 1997
    ..Such an hypothesis would predict that beta2m-deficient mice would also be resistant to experimental bullous pemphigoid, a disease with a pathogenesis thought to be much simpler than SLE, being the result of antibody directed ..
  83. ncbi Autoantibodies to human alpha6 integrin in patients with oral pemphigoid
    K C Bhol
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Dent Res 80:1711-5. 2001
    ..Oral pemphigoid sera and anti-alpha6 antibody produced separation of epithelium from basement membrane (blister formation) of normal human buccal mucosa, after 48 hours, in organ culture...
  84. ncbi Immediate hypersensitivity phenomena in bullous pemphigoid: critical concepts
    Monika Bowszyc-Dmochowska
    Dermatology, Medical University of Poznan, Poznan, Poland
    J Med 33:189-98. 2002
    The immediate hypersensitivity phenomena in bullous pemphigoid (BP) will be discussed in this review. There is prominent involvement of eosinophils in the pathogenesis of human BP...
  85. pmc The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit
    L Borradori
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam
    J Cell Biol 136:1333-47. 1997
    b>Bullous pemphigoid antigen 180 (BP180) is a component of hemidesmosomes, i.e., cell-substrate adhesion complexes...
  86. pmc Role of different pathways of the complement cascade in experimental bullous pemphigoid
    Kelly C Nelson
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 116:2892-900. 2006
    b>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease associated with autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 and inflammation...
  87. ncbi Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies
    Heike Leyendeckers
    Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
    J Invest Dermatol 120:372-8. 2003
    b>Bullous pemphigoid is a subepidermal blistering disease characterized by the synthesis of autoantibodies against the 180 kDa and the 230 kDa bullous pemphigoid antigens...
  88. pmc Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Exp Med 188:475-82. 1998
    b>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by deposition of autoantibodies at the basement membrane zone...
  89. ncbi Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease
    P Szabolcs
    Department of Pediatrics, Pediatric Stem Cell Transplant Program, Duke University Medical Center, Durham, NC 27710, USA
    Bone Marrow Transplant 30:327-9. 2002
    ..with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after ..
  90. ncbi Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Immunol 155:5449-54. 1995
    b>Bullous pemphigoid (BP) and herpes gestationis (HG) are subepidermal blistering diseases associated with an autoimmune response directed against BP180, an epidermal hemidesmosomal glycoprotein...
  91. ncbi Demonstration of antibody to 230 kDa bullous pemphigoid antigen in lichen planus-like keratosis
    M Seishima
    Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa cho 4 86, Ogaki City, 503 8502, Japan
    Eur J Dermatol 9:393-6. 1999
    We describe a 67-year-old man with lichen planus-like keratosis associated with anti-230 kDa bullous pemphigoid antigen (BPAG1) autoantibody...
  92. ncbi Novel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor)
    Masayo Okumura
    Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:6682-7. 2002
    BPAG1 (bullous pemphigoid antigen 1) was originally identified as a 230-kDa hemidesmosomal protein and belongs to the plakin family, because it consists of a plakin domain, a coiled-coil rod domain and a COOH-terminal intermediate ..
  93. ncbi A comparison of oral and topical corticosteroids in patients with bullous pemphigoid
    Pascal Joly
    Department of Dermatology and Biostatistics, INSERM Unite 519, University of Rouen, Rouen, France
    N Engl J Med 346:321-7. 2002
    b>Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly...
  94. ncbi Autoantibodies to the extracellular and intracellular domain of bullous pemphigoid 180, the putative key autoantigen in bullous pemphigoid, belong predominantly to the IgG1 and IgG4 subclasses
    E Laffitte
    Clinique de Dermatologie, , Rue Micheli du Crest 26, CH-1211 Geneva, Switzerland
    Br J Dermatol 144:760-8. 2001
    BACKGROUND: Autoantibodies to the extracellular domain (ECD) of bullous pemphigoid (BP) antigen 180 (BP180) are thought to play a crucial part in the pathophysiology of BP...
  95. ncbi Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid
    R Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    J Dermatol Sci 46:53-60. 2007
    ..Although the functions of APRIL have not been fully evaluated, recent studies suggest that circulating levels of APRIL are increased in various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis...
  96. pmc Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Blood 107:1063-9. 2006
    b>Bullous pemphigoid (BP) is an autoimmune disease associated with autoantibodies directed against the hemidesmosomal antigens anti-BP230 and anti-B180...
  97. doi Searching for foreign antigens as possible triggering factors of autoimmunity: Torque Teno virus DNA prevalence is elevated in sera of patients with bullous pemphigoid
    Antal Blazsek
    Department of Dermato Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
    Exp Dermatol 17:446-54. 2008
    ..We aimed to study the presence of TTV in a group of patients with autoimmune bullous diseases with a further goal to identify long-lasting foreign antigen, such as TTV as possible triggers of skin-specific autoimmunity...
  98. ncbi Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid
    S Verraes
    FRE 2260 CNRS, IFR 53 Biomolecules, University of Reims-Champagne Ardennes, Reims, France
    J Invest Dermatol 117:1091-6. 2001
    b>Bullous pemphigoid is a blistering disorder associated with autoantibodies directed against two components of hemidesmosomes, BP180 and BP230...
  99. ncbi Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy
    Ann Marie Powell
    Department of Dermatological Immunopathology, St John s Institute of Dermatology, St Thomas Hospital, London, England
    Arch Dermatol 141:705-10. 2005
    ..Results of epitope mapping studies show that IgG autoantibodies in up to 90% of PG serum samples target the well-defined membrane-proximal NC16a domain of BP180...
  100. ncbi Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins
    T Tanaka
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 266:12555-9. 1991
    b>Bullous pemphigoid is a subepidermal blistering disease in which patients have autoantibodies against the plaque of the hemidesmosome...
  101. ncbi Increased serum CCL28 levels in patients with atopic dermatitis, psoriasis vulgaris and bullous pemphigoid
    Shinji Kagami
    J Invest Dermatol 124:1088-90. 2005

Research Grants71

  1. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2010
    ..and 5) demonstrate a critical role for Mac-1 on neutrophils in two additional complement dependent models, bullous pemphigoid and thrombotic glomerulonephritis. The current application builds on these discoveries...
  2. PEMPHIGUS AND PEMPHIGOID
    Luis Diaz; Fiscal Year: 2005
    ..vulgaris (PV), non-endemic pemphigus foliaceus (PF), endemic PF [also known as Fogo Selvagem (FS)] and Bullous Pemphigoid (BP) that are summarized as follows: a) we have developed animals models of PV , PF, and FS by passive ..
  3. Mechanism of neurodegeneration in dystonia musculorum
    RONALD LIEM; Fiscal Year: 2007
    ..The gene that is mutated in dt mice is called dystonin, and is also known as bullous pemphigoid antigen 1 (BPAG1). BPAG1 is a member of the plakin family of cytoskeletal linker proteins...
  4. Complement Anaphylatoxin Receptors in Inflammation
    RICK WETSEL; Fiscal Year: 2005
    ..deficiency in the skin using established models of infectious dermatitis, immune-complex injury, and bullous pemphigoid, and 4) to determine the effect of C3a receptor deficiency in the peritoneum using established models of ..
  5. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2007
    ..FcRn has been shown to regulate the development of immune-mediated diseases such as rheumatoid arthritis and bullous pemphigoid. This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our ..
  6. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard S Blumberg; Fiscal Year: 2010
    ..FcRn has been shown to regulate the development of immune-mediated diseases such as rheumatoid arthritis and bullous pemphigoid. This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our ..
  7. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2009
    ..FcRn has been shown to regulate the development of immune-mediated diseases such as rheumatoid arthritis and bullous pemphigoid. This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our ..
  8. CYTOTOXIC MECHANISMS IN CUTANEOUS DISEASE
    David Norris; Fiscal Year: 1990
    ..Finally, we will begin pilot projects to study antibody dependent cytotoxicity in other skin diseases such as pemphigus vulgaris, bullous pemphigoid, alopecia areata, and vitiligo.
  9. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
    ..and F-actin, jet impingement to determine cellular adhesion, and immunohistochemistry for laminin, bullous pemphigoid antigen, and collagen VII...
  10. HEMIDESMOSOMES IN BULLOUS PEMPHIGOID
    GEORGE GIUDICE; Fiscal Year: 2007
    ..an autoimmune response directed against the BP180 protein is a key initiatory step in the pathogenesis of bullous pemphigoid and several other acquired blistering diseases...
  11. HEMIDESMOSOMES IN BULLOUS PEMPHIGOID
    GEORGE GIUDICE; Fiscal Year: 2007
    ..an autoimmune response directed against the BP180 protein is a key initiatory step in the pathogenesis of bullous pemphigoid and several other acquired blistering diseases...
  12. HEMIDESMOSOMES IN BULLOUS PEMPHIGOID
    GEORGE GIUDICE; Fiscal Year: 2002
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by the production of autoantibodies that react with components of the hemidesmosome, an adhesion-related organelle of basal epidermal keratinocytes...
  13. A Transgenic Animal Model for Pemphigoid
    KIM YANCEY; Fiscal Year: 2007
    ..b>Bullous pemphigoid antigen 2 (BPAG2), a type II transmembrane protein in hemidesmosomes, is a major autoantigen bound by such ..
  14. A Transgenic Animal Model for Pemphigoid
    KIM YANCEY; Fiscal Year: 2006
    ..b>Bullous pemphigoid antigen 2 (BPAG2), a type II transmembrane protein in hemidesmosomes, is a major autoantigen bound by such ..