Genomes and Genes
Summary: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Publications318 found, 100 shown here
- Control of regulatory T cell development by the transcription factor Foxp3Shohei Hori
Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
Science 299:1057-61. 2003..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
- Unraveling the genetics of autoimmunityLauren A Zenewicz
Department of Immunobiology, Yale University, New Haven, CT 06520, USA
Cell 140:791-7. 2010The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases...
- The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsIvaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
- Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseasesMichel Gilliet
Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Immunol 8:594-606. 2008..However, in some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate ..
- Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingKamran Ghoreschi
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 467:967-71. 2010..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
- Regulatory T cells exert checks and balances on self tolerance and autoimmunityKajsa Wing
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
Nat Immunol 11:7-13. 2010....
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6David Yen
Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
J Clin Invest 116:1310-6. 2006..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesS Sakaguchi
Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
J Immunol 155:1151-64. 1995..athymic nude (nu/nu) mice, all recipients spontaneously developed histologically and serologically evident autoimmune diseases (such as thyroiditis, gastritis, insulitis, sialoadenitis, adrenalitis, oophoritis, glomerulonephritis, and ..
- Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..This hypothesis proved correct. The mutant animals exhibited a defined profile of autoimmune diseases that depended on the absence of aire in stromal cells of the thymus...
- Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cellsYohei Iwata
Department of Immunology, Duke University Medical Center, Durham, NC, USA
Blood 117:530-41. 2011..The characterization of human B10 cells will facilitate their identification and the study of their regulatory activities during human disease...
- Human FoxP3+ regulatory T cells in systemic autoimmune diseasesMakoto Miyara
Internal Medicine Department, French national Reference center for SLE and antiphospholipid syndrome AP HP Hôpital Pitié Salpêtrière, 75013 Paris, France
Autoimmun Rev 10:744-55. 2011..of differentiation of Treg cells should bring new insights in the understanding of human chronic systemic autoimmune diseases. How Treg cells are compromised in these diseases is a challenging issue because the elucidation of the ..
- Omega-3 fatty acids in inflammation and autoimmune diseasesArtemis P Simopoulos
The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
J Am Coll Nutr 21:495-505. 2002..have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases. Coronary heart disease, major depression, aging and cancer are characterized by an increased level of ..
- Pervasive sharing of genetic effects in autoimmune diseaseChris Cotsapas
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 7:e1002254. 2011..We are thus able to leverage genetic data across diseases to construct biological hypotheses about the underlying mechanism of pathogenesis...
- TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1Ahjoku Amadi-Obi
Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 13:711-8. 2007....
- Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseasesXiaoyu Hu
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
Immunity 31:539-50. 2009..mechanisms reveal insights about how IFN-gamma regulates macrophage activation, inflammation, tissue remodeling, and helper and regulatory T cell differentiation and how Th1 and Th17 cell responses are integrated in autoimmune diseases.
- Transforming growth factor-beta regulation of immune responsesMing O Li
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Annu Rev Immunol 24:99-146. 2006..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
- The type I interferon system in the etiopathogenesis of autoimmune diseasesLars Rönnblom
Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
Ups J Med Sci 116:227-37. 2011Many patients with systemic autoimmune diseases have signs of a continuous production of type I interferon (IFN) and display an increased expression of IFN-α-regulated genes...
- Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosisYan Zheng
Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
Nature 445:648-51. 2007..of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis...
- Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceHui Chen Hsu
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Immunol 9:166-75. 2008..These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs...
- T(H)-17 cells in the circle of immunity and autoimmunityEstelle Bettelli
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Nat Immunol 8:345-50. 2007..Emerging data regarding T(H)-17 cells suggest a very important function for this T cell subset in immunity and disease...
- Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancerAmaar Ghazale
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Gastroenterol 102:1646-53. 2007..To determine the sensitivity and specificity of elevated serum IgG4 level for the diagnosis of autoimmune pancreatitis (AIP) and its ability to distinguish AIP from pancreatic cancer, its main differential diagnosis...
- Diagnosis of autoimmune pancreatitis: the Mayo Clinic experienceSuresh T Chari
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 4:1010-6; quiz 934. 2006..AIP has unique histologic features associated with infiltration of tissues of affected organs with abundant IgG4-positive cells. We propose expanded diagnostic criteria for AIP with a cohort of histologically confirmed AIP...
- Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune PancreatitisMakoto Otsuki
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
J Gastroenterol 43:403-8. 2008..A diagnostic trial of steroid therapy can be applied carefully by expert pancreatologists only in patients fulfilling criterion I alone with negative diagnostic work-up results for pancreatobiliary cancer...
- A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic diseaseMotohisa Yamamoto
First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
Mod Rheumatol 16:335-40. 2006..Mikulicz's disease thus differs from SS and may be a systemic IgG4-related plasmacytic disease...
- The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune diseaseB Afzali
Department of Nephrology and Transplantation, King s College London, Guy s and St Thomas Hospital, UK
Clin Exp Immunol 148:32-46. 2007..the importance of interferon (IFN)-gamma and IL-17 in the development and progression of inflammatory and autoimmune diseases (AD)...
- International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of PancreatologyTooru Shimosegawa
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
Pancreas 40:352-8. 2011..To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP)...
- The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseasesHelena Tlaskalova-Hogenova
Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
Cell Mol Immunol 8:110-20. 2011..g., probiotics and prebiotics) whose administration may aid in disease prevention and treatment...
- Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseasesJane Hoyt Buckner
Translational Research Program, Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101, USA
Nat Rev Immunol 10:849-59. 2010..This Review summarizes our progress so far towards understanding the role of CD4(+)CD25(+)FOXP3(+) T(Reg) cells in human autoimmune diseases and the impact that this knowledge might have on the diagnosis and treatment of these diseases.
- Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literatureAntonio Antico
Laboratorio di Patologia Clinica, Ospedale Civile, Cittadella, Italy
Autoimmun Rev 12:127-36. 2012To evaluate whether vitamin D levels are related to the risk of developing autoimmune diseases and whether supplementation with vitamin D can modify the course of the diseases.
- From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseasesVinod Kumar
Department of Genetics, University Medical Hospital Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
Semin Immunopathol 34:567-80. 2012..We also present novel approaches to identifying the causal variants in complex susceptibility loci and disease mechanisms...
- Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?Karen H Costenbader
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
Autoimmun Rev 11:604-9. 2012b>Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and inflammatory bowel disease, have complex pathogeneses and likely multifactorial etiologies...
- Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideRoberto Lande
Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Nature 449:564-9. 2007..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
- Interleukin-21: basic biology and implications for cancer and autoimmunityRosanne Spolski
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
Annu Rev Immunol 26:57-79. 2008..The key to harnessing the power of IL-21 will depend on better understanding its range of biological actions, its mechanism of action, and the molecular basis of regulation of expression of IL-21 and its receptor...
- A new clinicopathological entity of IgG4-related autoimmune diseaseTerumi Kamisawa
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
J Gastroenterol 38:982-4. 2003Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
- Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?M Feldmann
Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
Annu Rev Immunol 19:163-96. 2001..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
- Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient miceH Nishimura
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
Science 291:319-22. 2001..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.
- Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfShimon Sakaguchi
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Nat Immunol 6:345-52. 2005..They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens...
- Not always the bad guys: B cells as regulators of autoimmune pathologySimon Fillatreau
Simon Fillatreau is at the Immune regulation group, Deutsches Rheuma ForschungsZentrum, Chariteplatz 1, 10117 Berlin, Germany
Nat Rev Immunol 8:391-7. 2008..It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses...
- Modes of action of Freund's adjuvants in experimental models of autoimmune diseasesA Billiau
Rega Institute, University of Leuven, Belgium
J Leukoc Biol 70:849-60. 2001..Thus, in experimental autoimmune diseases, CFA-mediated activation of the innate immune compartment is important not only by regulating the early ..
- Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancersGordan Lauc
Glycobiology Laboratory, Genos, Zagreb, Croatia
PLoS Genet 9:e1003225. 2013..The results may also provide an explanation for the reported pleiotropy and antagonistic effects of loci involved in autoimmune diseases and haematological cancer.
- Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesShimon Sakaguchi
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Annu Rev Immunol 22:531-62. 2004....
- Autoimmune diseases, bipolar disorder, and non-affective psychosisWilliam W Eaton
Department of Mental Health, Johns Hopkins University, Baltimore, MD 21205, USA
Bipolar Disord 12:638-46. 2010Clinic-based studies of immune function, as well as comorbidity of autoimmune diseases, bipolar disorder, and schizophrenia, suggest a possible autoimmune etiology...
- MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseasesRujuan Dai
Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0342, USA
Transl Res 157:163-79. 2011..patterns now have been documented in a broad range of diseases including cancer as well as inflammatory and autoimmune diseases. This rapidly emerging field has revolutionized our understanding of normal immunoregulation and breakdown ..
- Hygiene hypothesis and autoimmune diseasesGraham A W Rook
Department of Infection, Centre for Clinical Microbiology, University College London UCL, London, UK
Clin Rev Allergy Immunol 42:5-15. 2012....
- Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseasesEyal Ben-Ami
Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Autoimmun Rev 10:410-5. 2011..immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases.
- Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related diseaseKazuichi Okazaki
Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Shinmachi, Hirakata, Osaka 573 1197, Japan
J Gastroenterol 46:277-88. 2011..The concept and diagnostic criteria of "IgG4-related disease" will be changed in accordance with future studies...
- The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosisA Alcina
Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
Genes Immun 11:439-45. 2010..These data may help to shape the contribution of each pathway to different disorders...
- Organ-specific disease provoked by systemic autoimmunityV Kouskoff
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
Cell 87:811-22. 1996..We suggest that human RA develops by an analogous mechanism...
- Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancerAlessio Fasano
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Physiol Rev 91:151-75. 2011..This review is timely given the increased interest in the role of a "leaky gut" in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs...
- Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseasesJuan Manuel Anaya
Center for Autoimmune Diseases Research CREA, Universidad del Rosario, Bogota, Colombia
Autoimmun Rev 11:276-80. 2012Many autoimmune diseases (ADs) share similar underlying pathology and have a tendency to cluster within families, supporting the involvement of shared susceptibility genes...
- Shared genetics in coeliac disease and other immune-mediated diseasesJ Gutierrez-Achury
Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
J Intern Med 269:591-603. 2011..Follow-up of individuals with a high genetic risk of CD and other autoimmune diseases could help to elucidate the role of environmental factors (such as infectious agents or alterations in the ..
- The Fas death factorS Nagata
Osaka Bioscience Institute, Japan
Science 267:1449-56. 1995..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
- Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic diseaseArezou Khosroshahi
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 62:1755-62. 2010..This study was performed to assess the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients with IgG4-RSD...
- Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing diseaseReiko Akitake
Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
Gut 59:542-5. 2010....
- TNF receptor 2 pathway: drug target for autoimmune diseasesDenise Faustman
Immunobiology Laboratory, Room 3602, Building 149, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, Massachusetts 02129, USA
Nat Rev Drug Discov 9:482-93. 2010Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells...
- IgG4-related disease: a cross-sectional study of 114 casesYoh Zen
Institute of Liver Studies, King s College Hospital, London, UK
Am J Surg Pathol 34:1812-9. 2010..Further study is necessary to conclude whether these features reflect different manifestations of a single disease entity or suggest different underlying etiologic factors...
- Autoimmune pancreatitis: proposal of IgG4-related sclerosing diseaseTerumi Kamisawa
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo, 113 8677, Japan
J Gastroenterol 41:613-25. 2006..We propose a new clinicopathological entity, "IgG4-related sclerosing disease", and suggest that AIP is a pancreatic lesion reflecting this systemic disease...
- Clinical diagnostic criteria of autoimmune pancreatitis: revised proposalKazuichi Okazaki
The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
J Gastroenterol 41:626-31. 2006
- Immunoglobulin G4-associated cholangitis: clinical profile and response to therapyAmaar Ghazale
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Gastroenterology 134:706-15. 2008..We describe clinical features, treatment response, and predictors of relapse in IAC and compare relapse rates in IAC with intrapancreatic vs proximal bile duct strictures...
- Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitisYoko Uchiyama-Tanaka
Department of Medicine II, Kansai Medical University, Osaka, Japan
Am J Kidney Dis 43:e18-25. 2004..To our knowledge, this is the first report of acute TIN associated with AIP. We suggest that AIP may be an etiologic factor in some cases of TIN...
- Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitisYoh Zen
Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takarama chi, Kanazawa 920 8640, Japan
Hepatology 45:1538-46. 2007..CONCLUSION: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs...
- Autoimmune diseases: insights from genome-wide association studiesGuillaume Lettre
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Hum Mol Genet 17:R116-21. 2008b>Autoimmune diseases occur when an individual's own immune system attacks and destroys his or her healthy cells and tissues...
- Immunomodulation by mesenchymal stem cells and clinical experienceK Le Blanc
Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
J Intern Med 262:509-25. 2007..Possible clinical applications include therapy-resistant severe acute graft-versus-host disease, tissue repair, treatment of rejection of organ allografts and autoimmune disorders...
- T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritisKeiji Hirota
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
J Exp Med 204:41-7. 2007..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
- A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlapPaula S Ramos
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
PLoS Genet 7:e1002406. 2011..analyses of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) and other autoimmune diseases (ADs) have been limited...
- Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceJun Shimizu
Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
Nat Immunol 3:135-42. 2002..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
- Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunityIlia J Elenkov
Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
Ann N Y Acad Sci 966:290-303. 2002..of chronic stress, severe exercise, and pregnancy and the postpartum period, through modulation of the systemic or local pro/antiinflammatory cytokine balance, may suppress or potentiate autoimmune diseases activity and/or progression.
- Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityP Bouillet
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Science 286:1735-8. 1999..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
- IgG4-related disease: historical overview and pathology of hematological disordersYasuharu Sato
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
Pathol Int 60:247-58. 2010..Moreover, some malignant lymphomas, especially mucosa-associated lymphoid tissue lymphoma, arise from ocular adnexal IgG4-related disease. In addition, IgG4-producing lymphoma also exists...
- Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIPTerumi Kamisawa
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
J Gastroenterol 45:471-7. 2010..It is unclear whether the long-term outcome is good because there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy...
- CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Thomas R Malek
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
Immunity 17:167-78. 2002..These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4(+)CD25(+) regulatory T cells...
- Implication of human endogenous retroviruses in the development of autoimmune diseasesEva Balada
Research Unit in Systemic Autoimmune Diseases, Vall d Hebron Research Institute, Barcelona, Spain
Int Rev Immunol 29:351-70. 2010..Some medical conditions, such as cancer and autoimmune diseases, are linked to the transcription of some of the HERVs genes, to the expression of HERVs proteins (that may ..
- Dendritic cells and cytokines in human inflammatory and autoimmune diseasesPatrick Blanco
CHU Bordeaux, 33076 Bordeaux, France
Cytokine Growth Factor Rev 19:41-52. 2008..and associated alterations in DC homeostasis have been implicated in various human inflammatory and autoimmune diseases. Targeting these cytokines with biological agents as already is the case with TNF and IL-1 represents a ..
- Biologic therapy for autoimmune diseases: an updateZiv Rosman
Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, POB 63, Holon, 58100 Israel
BMC Med 11:88. 2013....
- Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel WorkshopFrederick W Miller
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health Clinical Research Center, Bethesda, MD 20892 1301, USA
J Autoimmun 39:259-71. 2012b>Autoimmune diseases (AID) are a collection of many complex disorders of unknown etiology resulting in immune responses to self-antigens and are thought to result from interactions between genetic and environmental factors...
- B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) miceLino L Teichmann
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06519, USA
J Immunol 188:678-85. 2012....
- ANA screening: an old test with new recommendationsPier Luigi Meroni
Division of Rheumatology, Department of Internal Medicine, Istituto G Pini, University of Milan and IRCCS Istituto Auxologico Italiano, Milan, Italy
Ann Rheum Dis 69:1420-2. 2010The impact of autoimmune diseases is growing from both a clinical and a laboratory point of view. Diagnostic assays are now being transferred from dedicated specialised laboratories into high-throughput service laboratories...
- Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseasesChristine Beeton
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
Inflamm Allergy Drug Targets 10:313-21. 2011CCR7- effector memory T (TEM) lymphocytes are involved in autoimmune diseases such as multiple sclerosis, type 1 diabetes mellitus and rheumatoid arthritis. These cells express Kv1...
- Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimensGiuseppe Zamboni
Department of Pathology, University of Verona, Verona, Italy
Virchows Arch 445:552-63. 2004..Our intention was to establish key diagnostic criteria, define grades of severity and activity, identify features of potential subtypes and evaluate the diagnostic relevance of biopsy specimens...
- Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitisNarsing A Rao
Doheny Eye Institute, Keck School of Mewdicine, University of Southern California, Los Angeles, CA 90033, USA
Invest Ophthalmol Vis Sci 49:1161-71. 2008..However, no apoptosis has been detected during this phase. In this study, alphaA-crystallin upregulation in the retina and its antiapoptotic protective role were evaluated in early EAU...
- Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus documentSuresh T Chari
Mayo Clinic, Rochester, MN, USA
Pancreas 39:549-54. 2010..Whereas most experts agreed that the entities should be referred to as type 1 and type 2 AIP, respectively, others had concerns regarding use of the term "autoimmune" to describe IDCP...
- Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseasesCarlos G Grijalva
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave S, Ste 2600, The Village at Vanderbilt, Nashville, TN 37212, USA
JAMA 306:2331-9. 2011..Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete...
- Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?Terry J Smith
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI 48105, USA
Pharmacol Rev 62:199-236. 2010..IGF-I/IGF-IR signaling may also participate in the pathogenesis of autoimmune diseases, although its relationship with these processes seems complex and relatively unexplored...
- Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytesChangchun Xiao
Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 9:405-14. 2008..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region...
- Epstein-Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary reportO Barzilai
Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
Ann N Y Acad Sci 1108:567-77. 2007To date, it is believed that the origin of autoimmune diseases is one of a multifactorial background...
- Interferon beta inhibits the Th17 cell-mediated autoimmune response in patients with relapsing-remitting multiple sclerosisXin Zhang
Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Neurol Neurosurg 112:641-5. 2010..Our results have identified novel therapeutic mechanisms of IFNbeta, which inhibit Th17 cell differentiation in the context of the autoimmune response in MS...
- Autoimmune inflammation from the Th17 perspectiveJanette Furuzawa-Carballeda
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15 Tlalpan, Mexico City 14000, Mexico
Autoimmun Rev 6:169-75. 2007..arthritis (CIA), while knockout mice for the Th1 cytokine IL-12 (p35-/-) strongly develop both autoimmune diseases. Disease resistance by IL-23 knockout mice correlates well with the absence of IL-17-producing CD4(+) T ..
- Detecting shared pathogenesis from the shared genetics of immune-related diseasesAlexandra Zhernakova
Department of Medical Genetics, University Medical Centre Utrecht, Utrecht 3508 AB, The Netherlands
Nat Rev Genet 10:43-55. 2009..This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases...
- The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlationDavid A Copland
Academic Unit of Ophthalmology, Department of Clinical Sciences at South Bristol, UK
Invest Ophthalmol Vis Sci 49:5458-65. 2008....
- A novel automated indirect immunofluorescence autoantibody evaluationShaye Kivity
The Zabludowicz Center for Autoimmune Diseases, Tel Aviv University, Tel Aviv, Israel
Clin Rheumatol 31:503-9. 2012..antinuclear (ANAs) and anticytoplasmatic antibodies (ACyA), are essential diagnosing markers for several autoimmune diseases. The current gold standard method for ANA detection is manual indirect immunofluorescence (IIF) on human ..
- Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4T Takahashi
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
J Exp Med 192:303-10. 2000..of CTLA-4 for a limited period in normal mice leads to spontaneous development of chronic organ-specific autoimmune diseases, which are immunopathologically similar to human counterparts...
- Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseasesVictor Chi
Department of Physiology and Biophysics, UC Irvine, Irvine, CA 92697, USA
Toxicon 59:529-46. 2012..3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011...
- Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunityArthur M Krieg
Coley Pharmaceutical Group Inc, Wellesley, MA, USA
Immunol Rev 220:251-69. 2007..TLRs may face an extra challenge to induce anti-pathogen immune responses while avoiding the induction of autoimmune diseases. With the rapid growth in understanding of the biology of the TLRs has come an increasing awareness of ..
- Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseasesChristine Beeton
Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California Irvine, Irvine, CA 92697 4561, USA
Mol Pharmacol 67:1369-81. 2005..of autoreactive effector memory T (T(EM)) cells that play a major role in the pathogenesis of autoimmune diseases. We describe the characterization of the novel peptide ShK(L5) that contains l-phosphotyrosine linked via a ..
- Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseasesKarl Egerer
Department of Rheumatology and Clinical Immunology, Institute of Biochemistry, Humboldt University of Berlin, Berlin, Germany
J Rheumatol 29:2045-52. 2002..cytosolic generation of MHC class I restricted antigens, and it represents an abundant antigen in several autoimmune diseases. To investigate the effects of autoimmune inflammatory and perioperative traumatic cellular damage, we ..
- B-cell targeted therapies in human autoimmune diseases: an updated perspectiveMichael J Townsend
ITGR Biomarker Discovery Group, Genentech, South San Francisco, CA 94080, USA
Immunol Rev 237:264-83. 2010..In this review, we first discuss the role of B cells in driving autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, and Sjögren's syndrome, ..
- Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunityHonorio Torres-Aguilar
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
Autoimmun Rev 10:8-17. 2010..in the balance between tolerogenic and immunogenic functions of DCs and instigate the development of autoimmune diseases (ADs). Therefore, in recent years, DCs have emerged as therapeutic targets to control of ADs...
- Coeliac disease, autoimmune diseases and gluten exposureMervi Viljamaa
Department of Internal Medicine, Tampere University Hospital, Finland
Scand J Gastroenterol 40:437-43. 2005Gluten-free diet treatment has been proposed to prevent the development of autoimmune diseases in coeliac subjects...
- Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitisHideaki Miyoshi
The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
Pancreas 36:133-40. 2008..Recently, regulatory T cells (Tregs) have been reported to be involved in the development of various autoimmune diseases as well as B cell shifting to IgG4-producing plasmacytes...
- Infections and autoimmunity--friends or foes?Shaye Kivity
Center for Autoimmune Diseases, Department of Medicine A and C, Sheba Medical Center, Tel Hashomer 52662, Israel
Trends Immunol 30:409-14. 2009..The development of an autoimmune disease after infection tends to occur in genetically susceptible individuals. By contrast, some infections can protect individuals from specific autoimmune diseases (i.e. the hygiene hypothesis).
- Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric diseaseLynn D Cornell
Departments of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Surg Pathol 31:1586-97. 2007....
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Background: - Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Background: - Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis...
- Immune Regulation of Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2012..Furthermore, cancers, Rheumatoid Arthritis (RA) and other autoimmune diseases are prevalent in the aging VA population...
- Identification of Genetic and Epigenetic Alterations in SpondyloarthritisTibor T Glant; Fiscal Year: 2013..Because epigenetic alterations may be important etiologic components of autoimmune diseases, and St6galnac6 expression appears to play a key role in early inflammatory reactions, in Aim 3 we will ..
- H1R Signaling and Immune Deviation in EAECory Teuscher; Fiscal Year: 2013..Histamine is a potent mediator of inflammation and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis ..
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Malfunctioning B cells are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis...
- T cell regulation by N-glycosylationMichael Demetriou; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Autoimmune diseases like Multiple Sclerosis (MS) result from poorly understood interactions between genetic background of the ..
- Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNSArnold E Postlethwaite; Fiscal Year: 2010..and Musculoskeletal Diseases" Patients with rheumatoid arthritis (RA), other chronic arthritides and other autoimmune diseases inflammatory or not, have partial chronic disrupted sleep...
- Oklahoma Autoimmunity Center of ExcellenceJudith A James; Fiscal Year: 2013..clinical and basic science investigators who have research interests in the etiology and pathogenesis of autoimmune diseases and seek to identify novel therapeutics for more effective patient treatments...
- Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22Yaya Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Autoimmune diseases in aggregate represent a leading cause of morbidity and mortality...
- Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T cInsoo Kang; Fiscal Year: 2010..Of interest, decreased serum levels of 25(OH)VD3 have been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and ..
- Dietary Lipids and Silica-Accelerated AutoimmunityJames J Pestka; Fiscal Year: 2013DESCRIPTION (provided by applicant): Autoimmune diseases, a constellation of chronic, disabling illnesses that result from the immune system attacking the body's own tissues, are estimated to adversely affect up to 25 million ..
- Autoimmunity Center of Excellence (ACE) at StanfordCHARLES GARRISON FATHMAN; Fiscal Year: 2013..of Excellence (the Center) is the study of the regulation of CD4 T cells in pathogenesis and treatment of autoimmune diseases. The Center will support and be supported by other ACE groups across the United States;and will take ..
- Novel Macrolide Th17 InhibitorsJay K Kolls; Fiscal Year: 2012..Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis...
- MAPPING OF ARTHRITIS SUSCEPTIBILITY GENESTibor T Glant; Fiscal Year: 2013..it is likely involved in similar immune regulatory pathways, which also operate in RA and perhaps in autoimmune diseases in general...
- Molecular Mechanism of Immune Therapy for Bone Marrow FailuresPearlie K Epling-Burnette; Fiscal Year: 2013..for the activity of several inflammatory cytokines with known importance in LGL leukemia and other autoimmune diseases. In Specific Aim 1, we will confirm our hypothesis that loss of CD62L expression is mediated primarily by ..
- Modeling TH17 Cells in Acute GVHDJONATHAN STUART SERODY; Fiscal Year: 2010..Th17 cells have been implicated in the pathogenesis of multiple different autoimmune diseases including experimental autoimmune encephalitis, collagen-induced arthritis, and inflammatory bowel disease...
- NEURAL AND ENDOCRINE CONSEQUENCES OF PARITYROBERT STAFFORD BRIDGES; Fiscal Year: 2012..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders.
- Role of Sex Chromosome Complement in the CNS during Autoimmune DiseaseSienmi Du; Fiscal Year: 2013DESCRIPTION (provided by applicant): Most autoimmune diseases affect more females than males...
- Modulation of host immune defense by Pneumocystis beta-glucansEVA MARIA CARMONA PORQUERA; Fiscal Year: 2013..Specifically as PcP mostly affects patients with low CD4 counts such as with HIV, individuals with autoimmune diseases and hematological malignancies as a result of the diseases themselves or the treatments received...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMQuentin J Baca; Fiscal Year: 2010..of this process is likely to lead to safer and more effective therapies for infectious diseases, autoimmune diseases, and cancer...
- The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic targetSiba P Raychaudhuri; Fiscal Year: 2012..3 blockers we have further validated Kv1.3 as a potential therapeutic target for TEM cell mediated autoimmune diseases by demonstrating that autoreactive T cells from patients with multiple sclerosis, type-1 diabetes and ..
- Epigenetic downregulation of the antibody response and inhibition of autoimmunityPaolo Casali; Fiscal Year: 2013..it is exquisitely translational, as (at the time when expensive biologics enter clinical trials) it provies a sound mechanistic basis for use of inexpensive and available epigenetic modulators as therapeutics in autoimmune diseases. !
- Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint PainKaren H Costenbader; Fiscal Year: 2013..research, and small prevention trials strongly suggest that these nutritional agents reduce the risk of autoimmune diseases, reduce levels of circulating pro-inflammatory cytokines, and decrease chronic joint pain...
- Defining the molecular determinants of the threshold for autoimmune arthritisLih Yun Hsu; Fiscal Year: 2013..establish myself as an independent investigator in laboratory based research focused on the mechanisms of autoimmune diseases caused by dysregulated signal transduction in immune cells...
- Regulation of IFN-beta induction by P2X7 purinergic receptor signalingJUDITH ANNE SMITH; Fiscal Year: 2011..RELEVANCE: Macrophages participate in many inflammatory processes including responses to infections and autoimmune diseases by secreting cytokines...
- Progression of Autoimmunity During Puberty in SLEKATHLEEN M O'NEIL; Fiscal Year: 2011Researchers have puzzled for decades over why many autoimmune diseases like systemic lupus erythematosus (SLE) disproportionately affect women...
- Role of natural indoles in experimental autoimmune encephalomyelitisMitzi Nagarkatti; Fiscal Year: 2013DESCRIPTION (provided by applicant): There are over 80 different autoimmune diseases that are debilitating against which currently there is no cure...
- The Role of CD5 in B-Cell Development and AutoimmunityChander Raman; Fiscal Year: 2012..in some circumstances, B1a B-cells contribute substantially to the immunopathogenesis of chronic systemic autoimmune diseases such as rheumatoid arthritis (RA), Sjogren's syndrome and systemic lupus erythematosus (SLE)...
- Suppression of pathogenic autoantibodies in lupus by inhibition of AIDJohn D Mountz; Fiscal Year: 2012..autoimmunity and inflammation would both suggest novel therapeutic targets for arthritis and other autoimmune diseases and indicate unrecognized effects of therapies currently under development...
- The molecular mechanism of Aire: partnering with DNA-PKDiane J Mathis; Fiscal Year: 2013DESCRIPTION (provided by applicant): Autoimmune diseases afflict 7-10% of Americans, and their incidence is rising...
- K-Channels in Lymphocyte Function and AutoimmunityGEORGE KANIANTHARA CHANDY; Fiscal Year: 2012..suppress and/or eliminate effector memory (TEM) cells that have been implicated in the pathogenesis of many autoimmune diseases without affecting other immune cells. This proposal focuses on the voltage-gated Kv1...
- Gender Bias in Lupus: Contribution of Sex ChromosomesRam Raj Singh; Fiscal Year: 2012..goal of the current proposal is to investigate the contribution of sex chromosomes in the gender bias in autoimmune diseases such as systemic lupus erythematosus, which affect women much more frequently than men with a ratio of 9:1...
- Yale Autoimmunity Center of ExcellenceKevan C Herold; Fiscal Year: 2013..b>Autoimmune diseases are among the most common diseases in the US...
- ROLE OF COREGULATORS IN STEROID HORMONE-REGULATED TRANSCRIPTIONMichael R Stallcup; Fiscal Year: 2013..hormones control normal development and play important roles in diseases such as cancer, diabetes, and autoimmune diseases. The new basic knowledge obtained in this project will identify new potential targets for therapeutic ..
- HYPONATREMIA-INDUCED OSTEOPOROSISJoseph G Verbalis; Fiscal Year: 2010..diseases of the gastrointestinal tract, chronic obstructive pulmonary disease, organ transplantation, autoimmune diseases, genetic diseases, and marrow-based and neoplastic disorders in 18% in aggregate...
- Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?Bryce Binstadt; Fiscal Year: 2012DESCRIPTION (provided by applicant): Many systemic autoimmune diseases affect both the synovial joints and the cardiovascular system...
- Celiac Disease: From Genetic Risk to Disease DevelopmentSusan L Neuhausen; Fiscal Year: 2009..lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune diseases. No pharmacological treatment is available...
- Molecular Mechanisms of Ion Channels in T LymphocytesMichael D Cahalan; Fiscal Year: 2013..STIM and Orai proteins are being developed as targets for treatment of autoimmune diseases and prevention of transplant rejection...
- The relative roled of sex and genes during development of systemic autoimmunityTRINE NORGAARD JORGENSEN; Fiscal Year: 2010DESCRIPTION (provided by applicant): Many systemic autoimmune diseases are more common in females than in males...
- Molecular and Cellular Mechanisms of IL-17 SignalingXiaoxia Li; Fiscal Year: 2013..Considering the critical role of IL-17 in various inflammatory and autoimmune diseases, it is highly significant to investigate the mechanistic role of IL-17 signaling in the disease process, ..
- Ligands and cofactors required for RORgt function in the immune systemDan Littman; Fiscal Year: 2013..In addition, mice lacking RORyt are refractory to the induction of several autoimmune diseases. These findings suggest that RORyt may be an attractive target for pharmacological intervention in multiple ..
- Investigating the role of interleukin-22 in thymus functionJarrod Dudakov; Fiscal Year: 2013..recipients of allo-HSCT, but also for individuals with T cell deficiencies due to aging (lymphoid atrophy), autoimmune diseases, genetic causes (such as SCID), infectious diseases (HIV, hepatitis B/C), corticosteroids, shock, radio- or ..
- Sex Differences in Complement during Myocarditis/DCMDelisa Fairweather; Fiscal Year: 2013..applicant): Sex/gender differences exist for most chronic inflammatory diseases such as cardiovascular and autoimmune diseases. Men have a higher incidence and severity of cardiovascular diseases (CVDs) including myocarditis/dilated ..
- Sex Differences and Estrogen Receptors Regulate Dendritic Cells in InflammationSusan Kovats; Fiscal Year: 2010..by applicant): SEX DIFFERENCES AND ESTROGEN RECEPTORS REGULATE DENDRITIC CELLS IN INFLAMMATION Abstract Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are strongly female biased, yet the cellular and ..
- IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYKARL FRANK AUSTEN; Fiscal Year: 2012..Underlying allergic, asthmatic and autoimmune diseases are activated innate and adaptive host inflammatory pathways that are modulated by genetic and ..
- IL-22 in Thymic RegenerationMarcel R m van den Brink; Fiscal Year: 2013..recipients of allo-HSCT, but also for individuals with T cell deficiencies due to aging (lymphoid atrophy), autoimmune diseases, infectious diseases, shock, radio- or chemo-therapy and radiation injury (nuclear accident or terrorism).
- A Systems Biology Approach for Pediatric and Adult Autoimmune DiseasesMARIA VIRGINIA PASCUAL; Fiscal Year: 2013..this collaborative setting, a systems biology approach is proposed to focus on both pediatric and adult autoimmune diseases. The goals of the Center are: 1) To assess the efficacy of novel targeted therapies, 2) To develop simple ..
- High Throughput Screening of the Autoimmune EpitomeNancy J Olsen; Fiscal Year: 2010..lead to the development of new tools for clinicians and clinical researchers to use in the assessment of autoimmune diseases. PUBLIC HEALTH RELEVANCE: Autoimmune diseases are common causes of illness that are difficult to diagnose ..
- Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNFWeihong Pan; Fiscal Year: 2012..endothelial cells, and identify new therapeutic targets for intervention in neuroinflammation and CNS autoimmune diseases. PUBLIC HEALTH RELEVANCE Neuroinflammation is a common etiology in many CNS disorders, including infection (..
- Regulation of NETosis in antibacterial lung defenseEILEEN REMOLD-O'DONNELL; Fiscal Year: 2013..serious damage to host tissue and destroy anti-microbial defenses in pneumonia and other inflammatory and autoimmune diseases. To examine the mechanisms by which SerpinB1 inhibits NETosis, we will identify and characterize the ..
- Immunology, Inflammation, and EndometriosisSTACEY ANN MISSMER; Fiscal Year: 2012..A few studies suggest increased risk of autoimmune diseases among women with endometriosis...
- Mechanisms of Peripheral Induction of T-Cell ToleranceMATTHEW FRANKLIN MESCHER; Fiscal Year: 2013..self-Ags) in the secondary lymphoid organs (periphery) are critical for preventing development of autoimmune diseases, but can also limit the induction of desirable responses to self-Ags, as in the case of tumor vaccines, or ..
- Role of T Cell Mediated Immunity In Emotion And Stress ResponsivenessLeonardo H Tonelli; Fiscal Year: 2012..of studies report that individuals suffering from chronic inflammatory diseases including allergic and autoimmune diseases have a higher incidence of psychiatric complications related to increased emotional reactivity and poor ..
- Anti-Phospholipid Multiplex For Pathologic EpitopesPaul O Neilsen; Fiscal Year: 2010..some severe cases leads to death via emergency venous thrombosis/embolism;and secondary APS compounds other autoimmune diseases such as lupus and venous thromboembolism...
- Immune Regulation of CNS Viral RecrudescenceCornelia Bergmann; Fiscal Year: 2010..Their protective role in a model of viral persistence associated with limited ongoing inflammation may distinguish them from detrimental events prevailing during chronic inflammatory autoimmune diseases.
- Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicityTanya N Mayadas; Fiscal Year: 2013..natalizumab, which interferes with neutrophil trafficking have demonstrated marked therapeutic efficacy in autoimmune diseases, but also exhibited potentially fatal immunosuppression...
- AUTOIMMUNITY CENTER OF EXCELLENCEDavid Wofsy; Fiscal Year: 2013..by applicant): The central theme of this application is to clarify the role of regulatory T cells (Treg) in autoimmune diseases and explore their potential as therapeutic agents...
- Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA DamageNarsing A Rao; Fiscal Year: 2010..Once clarified, these results on initial events of TLR activation might have a global implications in autoimmune diseases and specific DNA damage in neuronal cells from TLR4 activation...
- Merkel cells specify innervating SAI sensory neuron phenotype.Erin G Reed-Geaghan; Fiscal Year: 2013..the treatment of a number of human conditions where there are inherent defects in the somatosensory system (autoimmune diseases, demyelinating diseases, genetic abnormalities, infections, injuries, metabolic disorders, toxic exposures, ..
- Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell functionUlf Beier; Fiscal Year: 2013..Likewise, therapies for autoimmune diseases and organ transplantation face the challenge of achieving enough immunosuppression to prevent organ ..
- Hunting for Endogenous Ligands for Invariant Natural Killer T CellsPeng George Wang; Fiscal Year: 2010..and chemokines in a rapid burst which has a broad immunological influence, including protection against autoimmune diseases, host responses to parasites and bacteria, and anti-tumor responses...
- MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITYKai Wucherpfennig; Fiscal Year: 2001..abstract) - The major histocompatibility complex (MHC) is an important susceptibility locus for many human autoimmune diseases. Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is strongly associated with ..
- MOLECULAR AND CELLULAR REGULATION OF TOLERANCEYongwon Choi; Fiscal Year: 2010..to limit immunological responses properly, because failure to do so may cause chronic inflammation or autoimmune diseases. Thus, understanding the molecular and cellular pathways that appropriately regulate immune responses will ..
- Analysis of Human B Cell Tolerance in Humanized MiceRoberta Pelanda; Fiscal Year: 2009b>Autoimmune diseases can develop upon defects in the process of tolerance, a process that eliminates and control self-reactive lymphocytes...
- Activation of Innate Immunity by Small RibonucleoproteinWestley Reeves; Fiscal Year: 2007Many patients with chronic autoimmune diseases such as systemic lupus erythematosus (SLE) develop autoantibodies to ubiquitous host cellular molecules, such as Sm small ribonucleoproteins (snRNPs) containing the small RNAs U1, U2, U4-6, ..
- The 5th International Leukocyte Signal Transduction WorkshopAmnon Altman; Fiscal Year: 2009..A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example...