thymus neoplasms

Summary

Summary: Tumors or cancer of the THYMUS GLAND.

Top Publications

  1. ncbi The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients
    Meinoshin Okumura
    Division of General Thoracic Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer 94:624-32. 2002
  2. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
  3. ncbi Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas
    Masayoshi Inoue
    Institute of Pathology, University of Wurzburg, D 97080 Wurzburg, Germany
    Cancer Res 63:3708-15. 2003
  4. ncbi New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China
    Gang Chen
    Department of Pathology, Shanghai Chest Hospital, People s Republic of China
    Cancer 95:420-9. 2002
  5. pmc Thymic malignancies: from clinical management to targeted therapies
    Ronan J Kelly
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1457, USA
    J Clin Oncol 29:4820-7. 2011
  6. ncbi Standard outcome measures for thymic malignancies
    James Huang
    Division of Thoracic Surgery, Department of Surgery, Yale University School of Medicine, Yale University, New Haven, Connecticut, USA
    J Thorac Oncol 5:2017-23. 2010
  7. ncbi Histologic classification of thymic epithelial tumors: comparison of established classification schemes
    Ralf J Rieker
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 98:900-6. 2002
  8. ncbi Immunohistochemical KIT (CD117) expression in thymic epithelial tumors
    Kazuo Nakagawa
    Department of Pathology, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Chest 128:140-4. 2005
  9. ncbi Prognostic and clinical relevance of the World Health Organization schema for the classification of thymic epithelial tumors: a clinicopathologic study of 108 patients and literature review
    Dae Joon Kim
    Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, CPO Box 8044, Seoul, South Korea
    Chest 127:755-61. 2005
  10. ncbi Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
    Hideo Tsuji
    Low Dose Radiation Effects Research Project Group, Radiation Hazards Research Group, and Environmental and Toxicological Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Res 64:8882-90. 2004

Research Grants

Detail Information

Publications309 found, 100 shown here

  1. ncbi The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients
    Meinoshin Okumura
    Division of General Thoracic Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer 94:624-32. 2002
    ..In this subsequent study, they examined the prognostic significance of this classification system...
  2. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
    ..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder...
  3. ncbi Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas
    Masayoshi Inoue
    Institute of Pathology, University of Wurzburg, D 97080 Wurzburg, Germany
    Cancer Res 63:3708-15. 2003
    ..However, other findings imply that types A and AB are biologically distinct from the others, any potential invasiveness being severely restricted by a medullary commitment in the precursor cell undergoing neoplastic transformation...
  4. ncbi New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China
    Gang Chen
    Department of Pathology, Shanghai Chest Hospital, People s Republic of China
    Cancer 95:420-9. 2002
    ..Whether WHO-defined histologic thymoma subtypes are of independent prognostic relevance has yet to be proved...
  5. pmc Thymic malignancies: from clinical management to targeted therapies
    Ronan J Kelly
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1457, USA
    J Clin Oncol 29:4820-7. 2011
    ..Here we discuss the results of large-scale genomic analyses conducted to date and review the most active chemotherapies and targeted treatments...
  6. ncbi Standard outcome measures for thymic malignancies
    James Huang
    Division of Thoracic Surgery, Department of Surgery, Yale University School of Medicine, Yale University, New Haven, Connecticut, USA
    J Thorac Oncol 5:2017-23. 2010
    ..Widespread adoption of this baseline will enhance the ability to compare results from different series...
  7. ncbi Histologic classification of thymic epithelial tumors: comparison of established classification schemes
    Ralf J Rieker
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 98:900-6. 2002
    ..Both classifications showed similar prognostic power. Interobserver agreement of the type B subgroups was only moderate. By simplification of the classifications, subgroups with distinct survival could be identified...
  8. ncbi Immunohistochemical KIT (CD117) expression in thymic epithelial tumors
    Kazuo Nakagawa
    Department of Pathology, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Chest 128:140-4. 2005
    ..The expression of KIT (CD117) in thymic epithelial tumors was investigated in order to evaluate its usefulness as a marker supporting differential diagnosis and choice of therapy...
  9. ncbi Prognostic and clinical relevance of the World Health Organization schema for the classification of thymic epithelial tumors: a clinicopathologic study of 108 patients and literature review
    Dae Joon Kim
    Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, CPO Box 8044, Seoul, South Korea
    Chest 127:755-61. 2005
    ..In this study, we present the clinical and histologic features of 108 thymomas and evaluate the usefulness of this histologic schema in view of the prognosis...
  10. ncbi Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
    Hideo Tsuji
    Low Dose Radiation Effects Research Project Group, Radiation Hazards Research Group, and Environmental and Toxicological Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Res 64:8882-90. 2004
    ..Recombination signal sequence-mediated deletions were present clonally in the thymocyte population, suggesting that thymocytes with a 5'-deletion of the Notch1 gene have a growth advantage and are involved in lymphomagenesis...
  11. ncbi WHO histologic classification is a prognostic indicator in thymoma
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 77:1183-8. 2004
    ..The histologic classification of thymoma has remained a subject of controversy for many years. In 1999, the World Health Organization Consensus Committee published a histologic typing system for tumors of the thymus...
  12. ncbi Long-term survival and prognostic factors in thymic epithelial tumours
    Federico Rea
    Thoracic Surgery, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy
    Eur J Cardiothorac Surg 26:412-8. 2004
    ..The aim of this study is to analyze long-term survival and the prognostic significance of some factors after surgical resection of thymic epithelial tumours...
  13. pmc Recurrent genetic aberrations in thymoma and thymic carcinoma
    A Zettl
    Departments of Pathology and Thoracic and Cardiovascular Surgery, The University of Würzburg, Germany
    Am J Pathol 157:257-66. 2000
    ..In addition to the possible tumorigenic role, the deletion in type B3 thymoma of chromosome 6, harboring the HLA locus, might play a role in the pathogenesis of paraneoplastic autoimmunity characteristic of thymoma...
  14. pmc No requirement for V(D)J recombination in p53-deficient thymic lymphoma
    M J Liao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill Medical School, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 18:3495-501. 1998
    ....
  15. pmc Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas
    Nicolas Girard
    Human Oncology and Pathogenesis Program HOPP, Weill Medical College of Cornell University, New York, New York, USA
    Clin Cancer Res 15:6790-9. 2009
    ..However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimum treatment of either entity is unknown...
  16. ncbi Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 76:878-84; discussion 884-5. 2003
    ..Surgery remains the mainstay of treatment for thymic epithelial tumors, and radiation and chemotherapy also have been applied widely as adjuvant and palliative procedures...
  17. ncbi Susceptibility to radiation-induced leukaemia/lymphoma is genetically separable from sensitivity to radiation-induced genomic instability
    E Boulton
    Department of Genetics, University of Leicester, UK
    Int J Radiat Biol 77:21-9. 2001
    ..TL-susceptibility in C57BL/6 is a recessive trait in contrast to the dominant inheritance of C57BL/6 resistance to radiation-induced chromosomal instability...
  18. ncbi Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 105:546-51. 2003
    ..The peak in late adulthood deserves further study. Variation in incidence by race suggests a role for genetic factors. Our study did not demonstrate broadly increased risk for malignancies following thymoma...
  19. ncbi Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after gamma-irradiation
    H Ohi
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi, Niigata, Japan
    Oncogene 26:5280-9. 2007
    ..These results suggest the order of genetic changes during lymphomagenesis, Bcl11b and Myc being at the early stage; whereas Ikaros, Pten and Notch1 at the late stage...
  20. ncbi World Health Organization classification of thymomas provides significant prognostic information for selected stage III patients: evidence from an international thymoma study group
    Alberto M Marchevsky
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 41:1413-21. 2010
    ..Power analysis shows that studies with much larger number of patients are needed to exclude the possibility that histologic type may provide significant prognostic information in other stages of the disease...
  21. ncbi Thirty-five-year follow-up analysis of clinical and pathologic outcomes of thymoma surgery
    Stefano Margaritora
    Division of General Thoracic Surgery, Catholic University, Rome, Italy
    Ann Thorac Surg 89:245-52; discussion 252. 2010
    ..With the unique opportunity of a 35-year follow-up in a single institution, thymomatous myasthenia gravis cohort, we investigated the influence of early and long-term clinical predictors...
  22. ncbi Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis
    Philipp Strobel
    Institute of Pathology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Clin Oncol 22:1501-9. 2004
    ..This retrospective study focused on the correlation of WHO-defined TET histotypes with survival and tumor recurrence in a large cohort of patients receiving different modes of treatment...
  23. ncbi Thymic tumors
    Frank C Detterbeck
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 77:1860-9. 2004
    ..Preoperative chemotherapy appears to increase the rate of complete resection and survival of patients with a stage III or IVa thymoma and should strongly be considered in such cases...
  24. ncbi Extrathoracic metastases of thymic origin: a review of 35 cases
    Tudor Vladislav
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Indiana University Simon Cancer Center, Indianapolis, IN, USA
    Mod Pathol 25:370-7. 2012
    ..Our study shows that all types of thymic tumors, regardless of histologic type, can be associated with invasion and metastases to thoracic and extrathoracic sites...
  25. ncbi Expression and mutational status of c-kit in thymic epithelial tumors
    Iacopo Petrini
    Department of Medical Oncology and Hematology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Thorac Oncol 5:1447-53. 2010
    ..We studied expression of c-kit in a large retrospective series of thymic epithelial malignancies and sequenced the whole gene in a subset of patients...
  26. ncbi Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors
    Kyoichi Kaira
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan
    J Clin Oncol 28:3746-53. 2010
    ..However, no satisfactory biologic explanation exists for this phenomenon. The aim of this study was to investigate the underlying biologic mechanisms of [(18)F]FDG uptake...
  27. pmc Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas
    Paolo A Zucali
    Department of Oncology, Humanitas Clinical Institute, IRCCS, Rozzano, Milan, Italy
    Cancer 116:4686-95. 2010
    ..Thymic malignancies are rare tumors. The insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown...
  28. ncbi Giant thymoma in the anterior-inferior mediastinum
    Stefan Limmer
    Department of Surgery, University Hospital of Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Interact Cardiovasc Thorac Surg 10:451-3. 2010
    ..Histology revealed a mixed stage I thymoma. The patient is doing well 36 months after resection and has no signs of recurrence. In literature, a significant increase in the risk of recurrence for thymomas >8 cm is reported...
  29. ncbi Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection
    Arjun Pennathur
    Heart, Lung, and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Thorac Cardiovasc Surg 141:694-701. 2011
    ..The objective of the present study was to evaluate the feasibility of VATS thymectomy for the treatment of early-stage thymoma and to compare the outcomes with those after open resection...
  30. ncbi Thymoma and thymic carcinoma: an update of the WHO Classification 2004
    Philipp Strobel
    Institute of Pathology, University of Wurzburg, D 97080, Wurzburg, Germany
    Surg Today 35:805-11. 2005
    ..We herein briefly update the reader with the most important new changes in the 2004 WHO classification of tumors of the thymus and to important new trends in the treatment of some of these tumors...
  31. doi Video-assisted thoracoscopic surgery versus robotic-assisted thoracoscopic surgery thymectomy
    Florian Augustin
    Clinical Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Ann Thorac Surg 85:S768-71. 2008
  32. ncbi Videothoracoscopic resection of stage II thymoma: prospective comparison of the results between thoracoscopy and open methods
    Yu Jen Cheng
    Division of Thoracic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Shih Chuan First Rd, Kaohsiung 80708, Taiwan
    Chest 128:3010-2. 2005
    ..We therefore compared the VTS and open (median sternotomy) methods to see whether VTS resection could be used as successfully to treat stage II thymoma disease...
  33. ncbi Radiation-induced-thymic lymphoma occurs in young, but not in old mice
    Masanori Utsuyama
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Exp Mol Pathol 74:319-25. 2003
    ..In conclusion, age advantage is present in the induction of thymic lymphoma after the treatment with FWI and the incidence definitely decreases in the presence of old factors...
  34. ncbi Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas
    Junko Sadohara
    Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
    Eur J Radiol 60:70-9. 2006
    ....
  35. ncbi Life span and thymic lymphoma incidence in high- and low-dose-rate irradiated AKR/J mice and commonly expressed genes
    Suk Chul Shin
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, 388 1, Ssangmun dong, Dobong gu, Seoul 132 703, Korea
    Radiat Res 174:341-6. 2010
    ..Functional studies for expressed genes associated with thymic lymphoma incidence in low-dose-rate exposed mice are currently under way...
  36. ncbi Thymoma: state of the art
    C R Thomas
    Department of Radiation Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Oncol 17:2280-9. 1999
    ..These observations have led to the development of multimodality therapy for the treatment of patients with advanced thymoma. In this article, we will review the current perspectives on the management of early stage and advanced thymoma...
  37. ncbi Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy
    Wouter K de Jong
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, NL 9700 RB, Groningen, The Netherlands
    Eur J Cancer 44:123-30. 2008
    ..53). Thymic epithelial tumours are rare. Excess mortality was observed in the majority of tumours. Surgery offers the best perspectives, even if the resection is incomplete...
  38. ncbi Management of thymomas
    Cameron D Wright
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Blake 1570, Boston, MA 02114, USA
    Crit Rev Oncol Hematol 65:109-20. 2008
    ..Thymomas are sensitive to both chemotherapy and radiation therapy and are utilized with good effects in unresectable patients...
  39. ncbi Thymoma and thymic carcinoma: molecular pathology and targeted therapy
    Philipp Strobel
    Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Thorac Oncol 5:S286-90. 2010
    ....
  40. ncbi Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice
    Suk Chul Shin
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Ssangmun dong, Dobong gu, Seoul, Republic of Korea
    Genomics 97:358-63. 2011
    ..Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice...
  41. ncbi Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    Y Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 10:2411-22. 1996
    ..These findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes, including meiosis, the normal growth of somatic tissues, immune development, and tumor suppression...
  42. ncbi A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus
    Olivier Tiffet
    Department of Thoracic Surgery, Royal Brompton Hospital, London, UK
    Chest 124:141-6. 2003
    ..To determine whether the new classification system for thymic carcinoid tumors/neuroendocrine carcinomas provides prognostic data, and to study the presentation, diagnosis, treatment, and prognostic factors of these rare tumors...
  43. ncbi Predictors of recurrence in thymic tumors: importance of invasion, World Health Organization histology, and size
    Cameron D Wright
    Division of General Thoracic Surgery, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, Mass 02114, USA
    J Thorac Cardiovasc Surg 130:1413-21. 2005
    ..This study sought to define predictors of recurrence after resection of thymic tumors...
  44. ncbi Evaluation and treatment of stage I and II thymoma
    Frank C Detterbeck
    Thoracic Surgery, Department of Surgery, Yale University, New Haven, Connecticut 06520 8062, USA
    J Thorac Oncol 5:S318-22. 2010
    ..Surgical resection is the mainstay of treatment, and every effort must be made to achieve a complete resection...
  45. ncbi Expression of podoplanin in thymoma: its correlation with tumor invasion, nodal metastasis, and poor clinical outcome
    Hisashi Tateyama
    Department of Pathology, Kasugai Municipal Hospital, Kasugai, Aichi 486 8510, Japan
    Hum Pathol 42:533-40. 2011
    ..0409) and B2/B3/combined thymomas (P = .0478). In conclusion, D2-40 immunostaining seems to be valuable for predicting the aggressive and metastatic potential of thymomas and the prognosis of the patients...
  46. ncbi [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome
    Athina Markou
    Department of Endocrinology, Middlesex Hospital, London, UK
    Eur J Endocrinol 152:521-5. 2005
    ..This is a rare case of concomitant CRH and ACTH secretion from a thymic carcinoid tumor; the case illustrates the usefulness of functional imaging with [(18)F]FDG PET in the diagnosis, management and follow-up of neuroendocrine tumors...
  47. pmc Molecular analysis of thymoma
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e42669. 2012
    ..A number of potential candidates for therapeutics were also identified...
  48. ncbi Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  49. ncbi WHO types A and AB thymomas: not always benign
    Rohit K Jain
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 23:1641-9. 2010
    ..Long-term clinical monitoring, therefore, appears to be justified in these cases. This study also shows the poor correlation between the WHO classification and tumor behavior...
  50. pmc Thymic epithelial tumors can develop along two different pathogenetic pathways
    R Zhou
    Institute of Pathology and Forensic Medicine, Zhejiang University Medical School, Zhejiang, China
    Am J Pathol 159:1853-60. 2001
    ..2 and 8q11.21-23. The absence of these aberrations might be the reason for the well-known benign behavior of type A thymomas as compared to types B3 and C tumors...
  51. ncbi Invasive spindle cell thymomas (WHO Type A): a clinicopathologic correlation of 41 cases
    Cesar A Moran
    Dept of Pathology, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 134:793-8. 2010
    ..This study stresses the fact that histologic features do not correlate with invasion or encapsulation because all thymomas, regardless of their histologic type, are capable of invasion...
  52. pmc What is Good's syndrome? Immunological abnormalities in patients with thymoma
    P Kelleher
    Department of Immunology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Clin Pathol 56:12-6. 2003
  53. ncbi Multidisciplinary treatment of malignant thymoma
    Lorenzo Spaggiari
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Curr Opin Oncol 24:117-22. 2012
    ..Although surgery remains the only curative treatment, the use of multimodality therapy for primary unresectable thymomas has led to change the clinical management of these tumors...
  54. ncbi Early experience with robot-assisted surgery for mediastinal masses
    Johannes Bodner
    Department of General and Transplant Surgery, Innsbruck University Hospital, Innsbruck, Austria
    Ann Thorac Surg 78:259-65; discussion 265-6. 2004
    ..We report the experience of a single institution with the minimally invasive resection of mediastinal masses using the da Vinci robotic surgical system...
  55. ncbi Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors
    Ken Ichi Sogawa
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Cancer 98:1822-9. 2003
    ..The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma...
  56. ncbi Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 94:809-13. 2003
    ..The combined use of oligonucleotide microarray, real-time RT-PCR, and ELISA analyses provides a powerful new approach to elucidate the in vivo molecular events surrounding the development and progression of thymoma...
  57. ncbi The World Health Organization (WHO) histologic classification of thymomas: a reanalysis
    Cesar A Moran
    Department of Pathology, University of Texas MD Anderson Cancer Center, Box 85, Houston, TX, USA
    Curr Treat Options Oncol 9:288-99. 2008
    ....
  58. ncbi Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors
    Emiko Takahashi
    Department of Pathology, Nagoya City University Medical School, Aichi, Japan
    Hum Pathol 34:1253-8. 2003
    ....
  59. ncbi Establishment and characterization of a novel cell line derived from human thymoma AB tumor
    Yesim Gokmen-Polar
    Department of Medicine, Indiana University School of Medicine, Walther Hall, 980W Walnut Street, C230, IN 46202, USA
    Lab Invest 92:1564-73. 2012
    ..The established cell line represents a biologically relevant new tool to investigate the molecular pathology of thymic malignancies and to evaluate the efficacy of novel therapeutics both in vitro and in vivo...
  60. ncbi Does adjuvant radiation therapy improve disease-free survival in completely resected Masaoka stage II thymoma?
    Ottavio Rena
    Thoracic Surgery Department, University of Eastern Piedmont A Avogadro, Novara, Italy
    Eur J Cardiothorac Surg 31:109-13. 2007
    ..To determine whether or not patients with completely resected Masaoka stage II thymoma benefit from postoperative radiotherapy (RT)...
  61. ncbi Expression of apoptosis-related markers and HER-2/neu in thymic epithelial tumours
    C C Pan
    Department of Pathology, National Yang Ming University, and Veterans General Hospital Taipei, Taiwan
    Histopathology 43:165-72. 2003
    ....
  62. ncbi World Health Organization histologic classification: an independent prognostic factor in resected thymomas
    Ottavio Rena
    Thoracic Surgery Department, University of Eastern Piedmont, Maggiore della Carità General Hospital, via Mazzini 18, Novara 28100, Italy
    Lung Cancer 50:59-66. 2005
    ..The present study demonstrated the World Health Organization histologic classification a good prognostic factor, such as completeness of surgical resection and Masaoka staging system...
  63. ncbi Thymoma: a clinicopathologic study based on the new World Health Organization classification
    Kazuo Nakagawa
    Divisions of Thoracic Surgery, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    J Thorac Cardiovasc Surg 126:1134-40. 2003
    ..This study explored the relationship between the histologic subtype of thymoma according to the new World Health Organization histologic classification and the clinical findings, as well as the prognostic significance of the classification...
  64. ncbi Aberrant methylation of tumour-related genes in thymic epithelial tumours
    Yukiko Hirose
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Lung Cancer 64:155-9. 2009
    ..Thymoma is an uncommon neoplasm derived from epithelial cells of the thymus. Few studies have addressed the genetic alterations that occur in the tumourigenesis of thymoma...
  65. ncbi Establishment, characterization and drug sensitivity testing in primary cultures of human thymoma and thymic carcinoma
    Volker Ehemann
    Institute of Pathology, University Hospital, Heidelberg, Germany
    Int J Cancer 122:2719-25. 2008
    ....
  66. ncbi Robot-assisted thymectomy is superior to transsternal thymectomy
    Benny Weksler
    University of Pittsburgh Medical Center, 200 Lothrop St, PUH C 800, Pittsburgh, PA 15213, USA
    Surg Endosc 26:261-6. 2012
    ..Robot-assisted thymectomy has emerged as an alternative to open transsternal surgery. The goal of this study was to compare perioperative outcomes in patients who underwent transsternal or robot-assisted thymectomy...
  67. ncbi Thymoma and thymic carcinoma
    Federico Venuta
    Cattedra di Chirurgia Toracica, Policlinico Umberto I, Universita di Roma Sapienza, V le del Policlinico 155, 00161, Rome, Italy
    Gen Thorac Cardiovasc Surg 60:1-12. 2012
    ..Integrated treatment modalities require strict cooperation between medical and radiation oncologists, thoracic surgeons, and pathologists...
  68. ncbi Robotic extended thymectomy for early-stage thymomas
    Alfredo Mussi
    Division of Thoracic Surgery, Department of Cardiac Thoracic and Vascular Surgery, University of Pisa, Pisa, Italy
    Eur J Cardiothorac Surg 41:e43-6; discussion e47. 2012
    ..The aim of this study was to report a single referral centre experience in robotic extended thymectomy for clinical early-stage thymomas, evaluating its safety, feasibility and efficacy, with special regard to oncological outcomes...
  69. ncbi [Clinicopathologic analysis of 52 cases of thymic epithelial tumor]
    Yu qing Ma
    Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China
    Zhonghua Bing Li Xue Za Zhi 39:249-54. 2010
    ..To study the clinicopathologic characteristics of thymic epithelial tumors and to evaluate the diagnostic reproducibility and clinical relevance of the 2004 WHO histologic classification system...
  70. pmc Diagnosis of thymoma
    S Suster
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    J Clin Pathol 59:1238-44. 2006
    ..A personal approach to the morphological diagnosis of thymoma is described, with a brief explanation for the rationale for simplifying the existing diagnostic categories...
  71. ncbi p16INK4, pRB, p53 and cyclin D1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma
    H Hirabayashi
    First Department of Surgery, Osaka University Medical School, Suita, Japan
    Int J Cancer 73:639-44. 1997
    ..However, inactivation of p16INK4A and RB may play a role in the progression of thymoma and thymic carcinoma...
  72. ncbi Usefulness of 18-F FDG PET/CT in the pre-treatment evaluation of thymic epithelial neoplasms
    Alberto Terzi
    Thoracic Surgery Unit, S Croce e Carle Hospital, Via Michele Coppino 26, 12100 Cuneo, Italy
    Lung Cancer 74:239-43. 2011
    ....
  73. ncbi Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance?
    Felice Granato
    Thoracic Surgery Unit, Department of Cardiothoracic and Vascular Surgery, Siena University Hospital, Siena, Italy
    Histopathology 60:437-42. 2012
    ..To assess the risk, for patients with thymoma, of developing an additional malignancy (AM)...
  74. ncbi [Correlation of amplification of chromosome 1 with histologic typing of thymic epithelial tumors]
    Yu qing Ma
    Department of Pathology, Xinjiang Medical University, Urumqi, China
    Zhonghua Bing Li Xue Za Zhi 40:820-4. 2011
    ..To study the correlation between amplification of chromosome 1 and histological typing and clinical staging of thymic epithelial tumors according to the WHO classification...
  75. ncbi Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14203, USA
    Chest 136:220-8. 2009
    ..Our objective was to investigate the expression of survivin, Bcl-2, p53, Ki-67, and Src in thymic neoplasms and analyze their interrelationship with clinicopathologic variables...
  76. ncbi Clinical management of thymoma patients
    Erin M Casey
    Indiana University School of Medicine, 535 Barnhill Dr RT 473, Indianapolis, IN 46202, USA
    Hematol Oncol Clin North Am 22:457-73. 2008
    ..Relapse has been documented decades after initial therapy with options for treating recurrent advanced stage disease. Prospective studies have been limited, and current studies aim to evaluate novel treatment options...
  77. ncbi Proliferative activity and apoptosis in thymic epithelial neoplasms
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 15:1326-32. 2002
    ..Bcl-2 and p53 protein expression may be useful markers in differentiating thymoma subtypes...
  78. ncbi Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors
    Masahiro Endo
    Division of Endoscopy and Diagnostic Radiology, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
    Lung Cancer 61:350-5. 2008
    ....
  79. ncbi Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report
    Edward S Kim
    Department of Thoracic Head and Neck Medical Oncology, Thoracic Cardiovascular Surgery, Radiation Therapy, Pathology, Radiology, and Biostatistics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Lung Cancer 44:369-79. 2004
    ..To evaluate tumor resectability after induction chemotherapy and to determine disease-free and overall survival rates of patients with locally advanced unresectable thymoma that received a multimodal treatment regimen...
  80. ncbi Thymoma and thymic carcinoma: therapeutic approaches
    Anupama Kurup
    Department of Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Lung Cancer 6:28-32. 2004
    ..Use of octreotide plus prednisone has produced responses in thymomas, but the dosing and schedule have not been clearly defined. Prospective studies have been limited, and, as such, enrollment in clinical trials is encouraged...
  81. ncbi Prediction of thymoma histology and stage by radiographic criteria
    Masahiro Yanagawa
    Department of Radiology, Osaka University Graduate School of Medicine, Suita City, Osaka, 565 0871, Japan
    Thorac Surg Clin 21:1-12, v. 2011
    ....
  82. ncbi Ectopic cervical thymoma: a mimic of T-lymphoblastic lymphoma
    Sheng Tsung Chang
    Department of Pathology, Chi Mei Medical Center, Yung Kang City, Tainan, Taiwan
    Pathol Res Pract 199:633-5. 2003
    ..Awareness of ectopic cervical thymoma, careful microscopic examination, and a proper selection of antibodies for immunohistochemistry will lead to the correct diagnosis...
  83. ncbi Ectopic cervical thymoma in the submandibular region
    Jaimanti Bakshi
    Department of Otolaryngology, Head and Neck Surgery, Institute for Medical Education and Research, Chandigarh, India
    J Otolaryngol 34:223-6. 2005
  84. ncbi Cervical thymoma
    A Rapoport
    Head and Neck Service, Heliopolis Hospital, Sao Paulo, Brazil
    Sao Paulo Med J 117:132-5. 1999
    ..Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma...
  85. ncbi Thymic carcinoma in children
    Nilgun Yaris
    Department of Pediatric Oncology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
    Pediatr Blood Cancer 47:224-7. 2006
    ..Histological and immunohistochemical studies confirmed lymphoepithelioma-like thymic carcinoma. She received systemic chemotherapy and radiotherapy. However, she died within 15 months due to progressive disease...
  86. ncbi Benign cervical thymoma masquerading as a malignant thyroid nodule
    Kashyap P Lanka
    Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi, India
    Clin Nucl Med 27:862-4. 2002
    ..Thymoma should be added to the gamut of false-positive findings in the neck for thyroidal (with Tc-99m pertechnetate) and malignant (with Tc-99m MIBI) tissue...
  87. ncbi Ectopic micronodular thymoma with lymphoid stroma
    Susanne Mende
    Virchows Arch 444:397-9. 2004
  88. ncbi Using the World Health Organization Classification of thymic epithelial neoplasms to describe CT findings
    Noriyuki Tomiyama
    Department of Radiology, Ehime National Hospital, 366, Yokogawara, Shigenobu, Ehime 791 0281, Japan
    AJR Am J Roentgenol 179:881-6. 2002
    ..Our purpose was to assess the CT features of various subtypes of thymic epithelial neoplasms on the basis of the 1999 World Health Organization classification...
  89. ncbi Thymoma in children: report of two cases and review of literature
    Girish Dhall
    Division of Pediatric Hematology Oncology, St Peter s University Hospital, New Brunswick, NJ 08903 0591, USA
    J Pediatr Hematol Oncol 26:681-5. 2004
    ..Both patients remain free of disease 3 years after surgery. One of the patients also has nevus sebaceous. The authors also discuss the possible association between the two disease entities...
  90. ncbi Radiation-induced incidence of thymic lymphoma in mice and its prevention by antioxidants
    P Dange
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Center, Mumbai 400 085, India
    J Environ Pathol Toxicol Oncol 26:273-9. 2007
    ..These results have provided significant new findings on the phenomenon of radiation-induced TL incidence related to gender and age at the time of irradiation and its prevention by postirradiation antioxidant feeding to mice...
  91. ncbi Invasive and noninvasive thymoma: distinctive CT features
    N Tomiyama
    Department of Radiology, Osaka University Medical School, Japan
    J Comput Assist Tomogr 25:388-93. 2001
    ..The purpose of this work was to evaluate the CT features of thymoma and to determine the most helpful findings in differentiating invasive from noninvasive thymoma...
  92. ncbi Does CT of thymic epithelial tumors enable us to differentiate histologic subtypes and predict prognosis?
    Yeon Joo Jeong
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    AJR Am J Roentgenol 183:283-9. 2004
    ..The aims of our study were to describe the CT findings of thymic epithelial tumors and to correlate these findings with the histopathologic subtypes and prognosis...
  93. ncbi Thymic carcinoma--analysis of nineteen clinicopathological studies
    D A Chung
    Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK
    Thorac Cardiovasc Surg 48:114-9. 2000
    ..This review summarises the major clinicopathological studies to assess more fully the prognostic importance of tumour histology and staging as well as treatment benefit...
  94. ncbi Ectopic intrathyroidal thymoma: a case report and review
    Jason B Cohen
    Division of Nuclear Medicine, Stanford University School of Medicine, Stanford, California 94305 5281, USA
    Thyroid 13:305-8. 2003
    ..A diagnosis of ectopic intrathyroidal thymoma was made only after appropriate histopathologic assessment of the surgical specimen...
  95. ncbi Prognostic factors in thymic epithelial neoplasms
    A Rios
    Department of General Surgery and Digestive Apparatus I, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain
    Eur J Cardiothorac Surg 21:307-13. 2002
    ..The primary thymic epithelial neoplasms (PTENs) are uncommon tumours with a broad spectrum of both biological and morphological features. The aim of this study is to analyse the prognostic factors that influence survival...
  96. ncbi Detection of primary and metastatic lesions by [18F]fluoro-2-deoxy-D-glucose PET in a patient with thymic carcinoid
    Takashi Fujishita
    The First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Respirology 12:928-30. 2007
    ..FDG-PET may be a useful tool for managing thymic carcinoids in patients with negative results on (123)I-MIBG SPECT or (99m)Tc-MDP imaging...
  97. pmc Thymic metastasis in breast cancer: a case report
    Sung Bin Park
    Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Korean J Radiol 8:360-3. 2007
    ..Recognition of an unusual breast cancer metastasis, such as to the thymus, as well as the usual patterns of breast cancer metastasis will facilitate an accurate, prompt diagnosis and its appropriate treatment...
  98. pmc Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience
    P Strobel
    Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Cancer 103:196-200. 2010
    ..Thymic carcinoma (TC) is a rare aggressive tumour. Median survival with current treatments is only 2 years. Sunitinib is a multi-targeted tyrosine kinase inhibitor that has shown benefit in various other cancers...
  99. ncbi Myasthenia gravis associated with ectopic cervical thymoma
    Hojin Choi
    Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
    J Clin Neurosci 15:1393-5. 2008
    ..We report the case of a patient with myasthenia gravis associated with ectopic cervival thymoma, whose myasthenic symptoms were well controlled after removal of the ectopic thymomas...
  100. ncbi Thymic carcinoma in children: a report from the Polish Pediatric Rare Tumors Study
    Teresa Stachowicz-Stencel
    Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University, Gdansk, Poland
    Pediatr Blood Cancer 54:916-20. 2010
    ..They are usually at an advanced stage when diagnosed and have both high recurrence and poor survival rates. In this report, the aim is to explore our experience in the treatment of thymic carcinomas in Polish children...
  101. ncbi Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma
    Satoshi Igawa
    Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Nagaizumi, Shizuoka 411 8777, Japan
    Lung Cancer 67:194-7. 2010
    ..Thymic carcinoma is a very rarely encountered neoplasm and no optimal chemotherapeutic regimen has been established yet...

Research Grants19

  1. IMMUNOBIOLOGY OF AUTOIMMUNITY
    Vanda Lennon; Fiscal Year: 1990
    ....
  2. CARCINOGENESIS OF B-LYMPHOCYTES IN RAT PEYER'S PATCHES
    MARVIN CUCHENS; Fiscal Year: 1990
    ..These studies will provide insights into the role of the Peyer's patch in the initiation and promotion of lymphoid malignancies by chemicals which are orally introduced into the gastrointestinal tract...
  3. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..The results of these studies will enhance our understanding of the role of apoptosis in the development of neoplastic disease. ..
  4. Roles of Nod2 in the Pathogenesis of Crohn's Disease
    Richard Flavell; Fiscal Year: 2008
    ..Furthermore, by using mice in which Rip2, the kinase downstream of Nod2, is deficient, we will try to reveal if the IBD pathology caused by Nod2 mutation is dependent on Rip2. [unreadable] [unreadable]..
  5. Vaccine responsiveness to Borrelia burgdorferi OspA
    Richard Flavell; Fiscal Year: 2007
    ..abstract_text> ..
  6. THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMAB
    Gerald Gleich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  7. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
  8. Epidermal Innervation as an Outcome Measure
    David Herrmann; Fiscal Year: 2006
    ..Dr. Herrmann will also examine a method to simplify the analysis of skin biopsy specimens, for easier application in large clinical trials. ..
  9. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ....
  10. Phase 2 study of [18F] FLT for PET imaging of brain tumors in children [IND 10436
    S Ted Treves; Fiscal Year: 2010
    ..This interdisciplinary project aims to validate and characterized the use of 18F-FLT-PET to evaluate these tumors, which, in turn, is expected to improve disease management and enhance the care of children afflicted with brain tumors. ..
  11. ALVEOLAR TYPE II CELL GROWTH IN INJURY
    RANDOLPH HASTINGS; Fiscal Year: 2003
    ..The project will evaluate the potential use of PTHrP-related therapeutic interventions that might speed or improve recovery following silica-induced lung injury. ..
  12. In-Vivo Confocal Imaging of Meissner's Corpuscles as a Measure of HIV Neuropathy
    David Herrmann; Fiscal Year: 2008
    ..In-vivo RCM of MCs may prove to have wide application for early identification of sensory peripheral neuropathies, and to assess effectiveness of therapy. [unreadable] [unreadable] [unreadable]..
  13. NEUROLOGICAL PARANEOPLASTIC SYNDROMES
    Jerome Posner; Fiscal Year: 2004
    ..In addition to routine evaluation, antibody studies and haplotyping will be performed and the patients will be followed serially during treatment. ..
  14. The Role of IL-2 in Autoimmune Diabetes
    Richard Flavell; Fiscal Year: 2007
    ..We will utilize our IL-2 knock-in mice to test these two mutually nonexclusive hypotheses. ..
  15. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  16. Dys/Regulation of the Immune System in Autoimmunity
    Richard Flavell; Fiscal Year: 2006
    ..The program is coordinated by frequent meetings of the program faculty and research workers bringing together these diverse approaches to address a common goal. ..
  17. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  18. Control of lymphomagenesis by ATM through ROS, mTOR and PP2A signaling
    Mingshan Yan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..