thrombophilia

Summary

Summary: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.

Top Publications

  1. ncbi Thrombophilia in young patients with cryptogenic stroke and patent foramen ovale (PFO)
    Pietro Offelli
    Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy
    Thromb Haemost 98:906-7. 2007
  2. ncbi Thrombophilia, clinical factors, and recurrent venous thrombotic events
    Sverre C Christiansen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:2352-61. 2005
  3. ncbi Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Shannon M Bates
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
    Chest 133:844S-886S. 2008
  4. pmc VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Shannon M Bates
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Chest 141:e691S-736S. 2012
  5. ncbi Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia
    N H Gehring
    Department of Pediatrics, , Humboldt University, Berlin, Germany
    Nat Genet 28:389-92. 2001
  6. ncbi Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome
    Giovanni Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Italy
    Semin Thromb Hemost 35:277-87. 2009
  7. ncbi Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview
    Paul R J Ames
    Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom
    Clin Appl Thromb Hemost 16:628-36. 2010
  8. ncbi Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 90:2220-9. 2008
  9. ncbi Increased rates of thrombophilia in women with repeated IVF failures
    Foad Azem
    Department of Obstetrics and Gynecology, Lis Maternity Hospital and Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Reprod 19:368-70. 2004
  10. ncbi Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial
    Carl A Laskin
    University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, Canada
    J Rheumatol 36:279-87. 2009

Detail Information

Publications363 found, 100 shown here

  1. ncbi Thrombophilia in young patients with cryptogenic stroke and patent foramen ovale (PFO)
    Pietro Offelli
    Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy
    Thromb Haemost 98:906-7. 2007
  2. ncbi Thrombophilia, clinical factors, and recurrent venous thrombotic events
    Sverre C Christiansen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:2352-61. 2005
    Data on the recurrence rate of venous thrombotic events and the effect of several risk factors, including thrombophilia, remain controversial...
  3. ncbi Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Shannon M Bates
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
    Chest 133:844S-886S. 2008
    This article discusses the management of venous thromboembolism (VTE) and thrombophilia, as well as the use of antithrombotic agents, during pregnancy and is part of the American College of Chest Physicians Evidence-Based Clinical ..
  4. pmc VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Shannon M Bates
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Chest 141:e691S-736S. 2012
    ..This guideline focuses on the management of VTE and thrombophilia as well as the use of antithrombotic agents during pregnancy.
  5. ncbi Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia
    N H Gehring
    Department of Pediatrics, , Humboldt University, Berlin, Germany
    Nat Genet 28:389-92. 2001
    ..causing a genetic disorder and explains the role of the F2 20210 G-->A mutation in the pathogenesis of thrombophilia. This work also illustrates the pathophysiologic importance of quantitatively minor aberrations of RNA ..
  6. ncbi Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome
    Giovanni Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Italy
    Semin Thromb Hemost 35:277-87. 2009
    ..The clinical impact of NAFLD on the proinflammatory/prothrombotic risk profile deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  7. ncbi Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview
    Paul R J Ames
    Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom
    Clin Appl Thromb Hemost 16:628-36. 2010
    ..In addition, antineutrophil cytoplasmic antibodies may shift the endothelial lining to proadhesive and prothrombotic surface. It is hoped that the review will represent a basis to foster novel research on this topic...
  8. ncbi Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 90:2220-9. 2008
    We examined the hypothesis that thrombophilia, hypofibrinolysis, and the endothelial nitric oxide synthase (eNOS) T-786C polymorphism are common, potentially treatable, and similar pathophysiologic causes of multifocal (three sites or ..
  9. ncbi Increased rates of thrombophilia in women with repeated IVF failures
    Foad Azem
    Department of Obstetrics and Gynecology, Lis Maternity Hospital and Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Reprod 19:368-70. 2004
    We investigated whether hereditary thrombophilia is more prevalent in women with recurrent IVF-embryo transfer failures.
  10. ncbi Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial
    Carl A Laskin
    University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, Canada
    J Rheumatol 36:279-87. 2009
    ....
  11. ncbi Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence
    A N Nicolaides
    Int Angiol 24:1-26. 2005
    b>Thrombophilia is the term now used to describe predisposition to increased risk of venous and occasionally arterial thromboembolism due to hematological abnormalities...
  12. ncbi The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)
    J Roemisch
    Aventis Behring GmbH, Preclinical Research and Development, Marburg, Germany
    Blood Coagul Fibrinolysis 13:433-41. 2002
    ..These results support the hypothesis that FSAP contributes to the scuPA-dependent plasma fibrinolytic potential, which can be impaired in plasmas containing the FSAP Marburg I polymorphism, for instance...
  13. ncbi The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion
    Jose Bellver
    Instituto Valenciano de Infertilidad IVI, University of Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 23:278-84. 2008
    The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly understood.
  14. ncbi An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Gastroenterology 137:2105-11. 2009
    ..We investigated whether plasma from cirrhotic patients has an imbalance of pro- vs anti-coagulation factors...
  15. ncbi The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
    Haematologica 92:199-205. 2007
    ..The aim of this investigation was to assess the rate of recurrent VTE after withdrawal of vitamin K antagonists, and to identify clinical parameters associated with a higher likelihood of recurrence...
  16. ncbi Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
    Circulation 110:566-70. 2004
    ..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown...
  17. ncbi Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia
    Gualtiero Palareti
    Dipartimento di Angiologia, Unità Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Circulation 108:313-8. 2003
    ..The aim of the present study was to assess the predictive value of D-dimer for recurrent VTE in subjects with a previous unprovoked event who are either carriers of inherited thrombophilia or not.
  18. ncbi Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 87:1361-6. 2001
    ..The impact of certain genotypes must be examined in relation to other established risk factors and potentially new therapeutic strategies...
  19. ncbi The 677C-->T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head
    Charalampos G Zalavras
    Department of Orthopedic Surgery, LAC USC Medical Center, University of Southern California, Los Angeles, USA
    Haematologica 87:111-2. 2002
  20. ncbi Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study
    Giorgio Mello
    The Maternal Fetal Medicine High Risk Pregnancies Unit, University of Florence, Italy
    Hypertension 46:1270-4. 2005
    The role of thrombophilia in the pathogenesis of preeclampsia is controversial. The aim of this case-controlled study was to determine whether thrombophilia increases the risk of preeclampsia or interferes with its clinical course...
  21. ncbi Recurrent miscarriage and thrombophilia: an update
    Kelly McNamee
    Liverpool Women s NHS Foundation Trust, Liverpool, UK
    Curr Opin Obstet Gynecol 24:229-34. 2012
    Acquired and inherited thrombophilia is an important research avenue in the recurrent miscarriage field. The optimum treatment for patients with recurrent miscarriage and a confirmed thrombophilia remains a contentious issue...
  22. ncbi Postnatal screening for thrombophilia in women with severe pregnancy complications
    Z Alfirevic
    University Department of Obstetrics and Gynecology, Liverpool Women s Hospital, University of Liverpool, United Kingdom
    Obstet Gynecol 97:753-9. 2001
    To examine the prevalence of maternal thrombophilia in women with severe preeclampsia/eclampsia, placental abruption, fetal growth restriction, and unexplained stillbirth.
  23. ncbi Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications
    Michael J Kupferminc
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    J Matern Fetal Neonatal Med 24:1042-5. 2011
    ..The aim of this study was to investigate the effect of low molecular weight heparin (LMWH) on incidence of adverse outcome in women with thrombophilias and previous severe pregnancy complications...
  24. pmc C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies
    Al Carrera-Marín
    Division of Rheumatology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Lupus 21:1497-505. 2012
    ..Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 deficient (C6(-/-)) mice...
  25. ncbi The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus
    Junzo Nojima
    Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka 565 0871, Japan
    Haematologica 91:699-702. 2006
    ..Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE...
  26. ncbi Geographic distribution of the 20210 G to A prothrombin variant
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands
    Thromb Haemost 79:706-8. 1998
    ..Since this distribution within Europe is very different to that of another prothrombotic mutation (factor V Leiden or factor V R506Q), founder effects are the most likely explanation for the geographical distribution of both mutations...
  27. ncbi Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis
    Marcello Di Nisio
    Department of Medicine and Aging, Centre for Aging Sciences, Internal Medicine Unit, University G d Annunzio Foundation, Chieti, Italy
    Blood 118:2670-8. 2011
    b>Thrombophilia has been associated with pregnancy complications and recurrent miscarriage...
  28. ncbi Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Childhood Thrombophilia Study Group
    S Ehrenforth
    Department of Internal Medicine, University Hospital Frankfurt, Germany
    Eur J Pediatr 158:S97-104. 1999
    To evaluate the role of multiple established and potential causes of childhood thrombophilia, 285 children with a history of thrombosis aged neonate to 18 years (first thrombotic onset) were investigated and compared with 185 healthy ..
  29. ncbi The relationship between pregnancy induced hypertension and congenital thrombophilia
    S Cansun Demir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University Balcali, Adana, Turkey
    Saudi Med J 27:1161-6. 2006
    ..To investigate the relationship between some thrombophilic parameters and pregnancy induced hypertension (PIH)...
  30. ncbi Severe preeclampsia and high frequency of genetic thrombophilic mutations
    M J Kupferminc
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
    Obstet Gynecol 96:45-9. 2000
    To determine whether severe preeclampsia is associated with genetic thrombophilic mutations or other types of thrombophilia.
  31. ncbi Preeclampsia and its interaction with common variants in thrombophilia genes
    M P M De Maat
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Thromb Haemost 2:1588-93. 2004
    ..Polymorphisms in the thrombophilia genes [plasminogen activator inhibitor type 1 [PAI-1 -675(4G/5G)], thrombin activatable fibrinolysis inhibitor ..
  32. ncbi Reactive thrombocytosis might contribute to chemotherapy-related thrombophilia in patients with lung cancer
    Gabriella Zecchina
    Division of Hematology, San Luigi Hospital, University of Turin, Orbassano, Italy
    Clin Lung Cancer 8:264-7. 2007
    ..Thrombotic risk is increased in patients with cancer and further potentiated by chemotherapy. We assessed whether early hemostatic alterations could represent a risk factor for thrombosis in patients undergoing chemotherapy for lung cancer...
  33. ncbi Coagulation and inflammation. Molecular insights and diagnostic implications
    S Lipinski
    Institut für Klinische Molekularbiologie, Christian Albrechts Universitat, Schittenhelmstr 12, 24105 Kiel, Germany
    Hamostaseologie 31:94-102, 104. 2011
    ....
  34. ncbi The prevalence of thrombophilia in patients with chronic venous leg ulceration
    Rhoda K Mackenzie
    Vascular Surgery Unit, Royal Infirmary, Edinburgh, United Kingdom
    J Vasc Surg 35:718-22. 2002
    b>Thrombophilia is increasingly recognized as a risk factor for deep venous thrombosis (DVT), which in turn is a major risk factor for chronic venous ulceration (CVU). However, the relationship between thrombophilia and CVU remains unknown...
  35. ncbi Hemostatic changes in thyroid diseases: haemostasis and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:203-8. 2006
    ....
  36. ncbi Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia
    C Ciacci
    Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, University of Naples Federico II, Naples, Italy
    Dig Liver Dis 41:717-20. 2009
    ..Adverse pregnancy outcomes are more frequent in celiac than in non-celiac women...
  37. ncbi Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure
    Hussein S Qublan
    Department of Obstetrics and Gynecology, Royal Medical Services, Jordan Armed Forces, Irbid, Jordan
    Hum Reprod 21:2694-8. 2006
    ..The objective of this study was to determine the incidence of undiagnosed thrombophilic factors and its relation to IVF and embryo transfer failure in women who have had three or more previous IVF-embryo transfer cycles...
  38. ncbi Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Lancet 362:523-6. 2003
    ..We aimed to determine the incidence of recurrence of VTE in relation to clinical risk factors and standard laboratory testing for heritable thrombophilic defects...
  39. ncbi Upper extremity deep venous thrombosis in the population-based Malmö thrombophilia study (MATS). Epidemiology, risk factors, recurrence risk, and mortality
    Nazim Isma
    University of Lund Centre for Thrombosis and Haemostasis, Malmo University Hospital, S 20502 Malmo, Sweden
    Thromb Res 125:e335-8. 2010
    ..Deep venous thrombosis (DVT) is much less common in the upper than in the lower extremity. Furthermore, there is limited information on risk factors for and the prognosis of upper extremity (UE)DVT in the general population...
  40. ncbi Thrombophilia and hypercoagulability
    Houria I Hassouna
    Department of Medicine, Michigan State University, East Lansing, MI 48824 1313, USA
    Med Princ Pract 18:429-40. 2009
    This is a review of less well-known aspects of thrombophilia and hypercoagulability as they relate to thrombosis...
  41. ncbi Inherited thrombophilia and pregnancy complications revisited
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Obstet Gynecol 112:320-4. 2008
    ..An inherited thrombophilia is only one of many factors that lead to development of these diseases and is unlikely to be the unique factor ..
  42. ncbi Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives
    Willem M Lijfering
    Department of Hematology, University Medical Center Groningen, The Netherlands
    Blood 113:5314-22. 2009
    b>Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia...
  43. ncbi Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies
    Guy Young
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Circulation 118:1373-82. 2008
    The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies.
  44. ncbi Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan
    M C Shen
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei
    Thromb Res 99:447-52. 2000
    The relative risks (odds ratio, OR) of various risk factors for venous thrombophilia, including sex, antithrombin III, protein C (PC), protein S (PS) and plasminogen deficiencies, and C677T homozygous mutation of ..
  45. pmc Is thrombophilia a major risk factor for deep vein thrombosis of the lower extremities among Lebanese patients?
    R Kreidy
    Department of Vascular Surgery, Saint George Hospital, University Medical Center, Youssef Sursock Street, PO Box 166378, Achrafieh, Beirut 11002807, Lebanon
    Vasc Health Risk Manag 5:627-33. 2009
    ..The aim of this study is to define risk factors including inherited genetic abnormalities among Lebanese patients with lower extremity deep vein thrombosis. We report the clinical outcome of patients with thrombophilia.
  46. ncbi Inherited thrombophilia in ischemic stroke and its pathogenic subtypes
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Stroke 32:1793-9. 2001
    ..a proportion of ischemic strokes, but few studies have addressed this association or the association between thrombophilia and pathogenic subtypes of stroke...
  47. ncbi High risk of recurrent venous thromboembolism in men
    T Baglin
    Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Thromb Haemost 2:2152-5. 2004
    ..We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE)...
  48. ncbi Screening for inherited thrombophilia might be warranted among Eastern Mediterranean sickle-beta-0 thalassemia patients
    Hussain Isma'eel
    American University of Beirut Medical Center
    J Thromb Thrombolysis 22:121-3. 2006
    The role of genetic thrombophilia in the development of both micro and macro vascular complications in patients with hemoglobinopathies (Sickle cell disease and thalassemia) have been investigated with some studies negating its role ..
  49. ncbi Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies
    Gili Kenet
    Pediatric Hematology and Oncology, University Hospital of Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Circulation 121:1838-47. 2010
    The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies.
  50. ncbi Hypercoagulation and thrombophilia in liver disease
    P G Northup
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    J Thromb Haemost 6:2-9. 2008
    ..Critical areas lacking clinical information are highlighted and future areas of research interest are defined with an aim to foster clinical research in this field...
  51. ncbi The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Haematologica 91:695-8. 2006
    ..9, 95% CI 1.0-3.9); the carriers of PC or PS deficiency had a marginal increase in risk (hazard ratio 1.4, 95% CI 0.9-2.2). In conclusion, patients with AT deficiency are potential candidates for long-term oral anticoagulation...
  52. ncbi The psychological impact of testing for thrombophilia: a systematic review
    D M Cohn
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 6:1099-104. 2008
    Nowadays, large numbers of patients are tested for thrombophilia, even though the benefits of this strategy remain unclear...
  53. ncbi Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese
    Hala Tamim
    Thromb Haemost 88:691-2. 2002
  54. ncbi Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review
    E R Morrison
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland
    Thromb Haemost 87:779-85. 2002
    ..which appear to be associated with FVL and, to a lesser extent, MTHFR C677T. There is little value in antenatal screening for prothrombotic polymorphisms to predict the development of pre-eclampsia or gestational hypertension...
  55. ncbi Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives
    J C Meijers
    Department of Haematology, University Medical Center Utrecht, The Netherlands
    Thromb Haemost 84:9-14. 2000
    ..These data indicate that the OC-induced inhibition of endogenous fibrinolysis takes place in a factor XI-independent way and is more pronounced on desogestrel than on levonorgestrel-containing OC...
  56. ncbi Coagulation in sepsis
    Andre Amaral
    Dept of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Intensive Care Med 30:1032-40. 2004
    ..In this article, we explore the complex relationship between inflammation and coagulation and how improved understanding of this interaction has led to the development of new therapeutic agents for patients with severe sepsis...
  57. ncbi Risk factors for thrombophilia in extrahepatic portal vein obstruction
    Massimo Primignani
    Gastroenterology and Gastrointestinal Endoscopy Service, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
    Hepatology 41:603-8. 2005
    Scant information exists on the role of thrombophilia in extrahepatic portal vein obstruction (EHPVO)...
  58. ncbi Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped
    Gualtiero Palareti
    Department of Angiology, Unità Ricerca Clinica sulla Trombofilia M Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 87:7-12. 2002
    ..Only five idiopathic recurrences occurred in the 186 patients with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for VTE recurrence when performed after OAT discontinuation...
  59. ncbi Factor V Leiden thrombophilia
    Jody Lynn Kujovich
    Northwest Cancer Specialists, Portland, OR 97227, USA
    Genet Med 13:1-16. 2011
    ..In the absence of evidence that early diagnosis reduces morbidity or mortality, decisions regarding testing at-risk family members should be made on an individual basis...
  60. ncbi Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
    ..Venous thrombosis is one of the leading causes of maternal morbidity and mortality...
  61. ncbi Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review
    Wai Khoon Ho
    Department of Haematology, Royal Perth Hospital and Centre for Clinical Research Excellence, University of Western Australia, Perth
    Arch Intern Med 166:729-36. 2006
    ..These data call into question the cost-effectiveness of routine testing for these common inherited thrombophilic polymorphisms among patients with a first episode of VTE...
  62. ncbi Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia
    J C Livingston
    Department of Maternal-Fetal Medicine, University of Tennessee, Memphis, TN, USA
    Am J Obstet Gynecol 185:153-7. 2001
    ..CONCLUSION: Inherited thrombophilias are not associated with severe preeclampsia...
  63. ncbi Does thrombophilia testing help in the clinical management of patients?
    Saskia Middeldorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 143:321-35. 2008
    b>Thrombophilia can be identified in about half of all patients presenting with venous thrombosis...
  64. pmc Prothrombin gene G20210A mutation and obstetric complications
    Robert M Silver
    Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 115:14-20. 2010
    ..To estimate whether maternal carriage of the prothrombin gene G20210A mutation is associated with pregnancy loss, preeclampsia, placental abruption, or small for gestational age (SGA) neonates in a low-risk, prospective cohort...
  65. ncbi Inherited thrombophilic risk factors and venous thromboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism
    M Margaglione
    Unita di Aterosclerosi e Trombos, Istituto di Ricovera e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Chest 118:1405-11. 2000
    ..To investigate whether the FII A(20210) mutation is associated with isolated pulmonary embolism (PE)...
  66. ncbi Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:139-44. 2007
    ..65-1.98) in the hyperhomocysteinemic group and 0.58 (95% CI, 0.31-1.07) in the normohomocysteinemic group. The results of our study do not show that homocysteine lowering by B vitamin supplementation prevents recurrent venous thrombosis...
  67. ncbi Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale
    Vesa Karttunen
    Department of Neurology, Oulu University Central Hospital, Box 25, FIN 90029 Oulu, Finland
    Blood Coagul Fibrinolysis 14:261-8. 2003
    ..140). Among the patients with prothrombotic states, Valsalva manoeuvre was common at onset of stroke. Our results support the possibility of paradoxical embolism behind strokes in patients with patent foramen ovale...
  68. ncbi Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias
    M J Kupferminc
    The Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel
    Hypertens Pregnancy 20:35-44. 2001
    To evaluate the benefit of combined low-molecular-weight (LMW) heparin and aspirin for prophylaxis in women carriers of thrombophilia who had previously suffered from severe obstetric complications.
  69. ncbi Heritable thrombophilia and hypofibrinolysis. Possible causes of retinal vein occlusion
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Arch Ophthalmol 117:43-9. 1999
    To determine whether heritable thrombophilia and hypofibrinolysis were risk factors for retinal vein occlusion.
  70. ncbi Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis?
    Birgit Linnemann
    Division of Vascular Medicine, Department of Internal Medicine, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7 D 60590 Frankfurt Main, Germany
    Thromb Res 121:743-50. 2008
    ..Whether thrombophilic disorders, which are established risk factors for venous thromboembolism (VTE), also increase the risk of arterial thrombosis is still unknown...
  71. ncbi Successful pregnancy outcome in women with bad obstetric history and recurrent fetal loss due to thrombophilia: effect of unfractionated heparin and low-molecular weight heparin
    Kanjaksha Ghosh
    Deptartment of Haemostasis, Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Clin Appl Thromb Hemost 14:174-9. 2008
    ..All the women were positive either for a solitary or for a combination of acquired and heritable thrombophilia markers. In all, 23 patients were treated with unfractionated heparin and 9 with low-molecular weight heparin...
  72. ncbi Central retinal vein occlusion and thrombophilia risk factors
    Y P Adamczuk
    Department of Haematology, Thrombosis and Haemostasis, Favaloro University, Buenos Aires, Argentina
    Blood Coagul Fibrinolysis 13:623-6. 2002
    ..5%, P < 0.001 and 2.1%, P < 0.01, respectively). Both hyperhomocysteinaemia and antiphospholipid antibodies seem to be associated with CRVO. A search for acquired thrombophilia is advisable in patients with CRVO.
  73. ncbi Hereditary thrombophilia as a cause of Budd-Chiari syndrome: a study from Western India
    D Mohanty
    Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Hepatology 34:666-70. 2001
    ..09%) of BCS and 3 (9.09%) of PVT cases. Thus overall, 59% of the BCS and 30% of the PVT cases could be explained by at least one of the etiologic factors studied...
  74. ncbi Perioperative strategies and thrombophilia in children with extrahepatic portal vein obstruction undergoing the meso-Rex bypass
    Rukhmi Bhat
    Division of Hematology, Oncology and Stem Cell Transplantation, Ann and Robert H Lurie Children s Hospital of Chicago, IL 60611, USA
    J Gastrointest Surg 17:949-55. 2013
    ..Although usually idiopathic in etiology, genetic and acquired thrombophilia have been implicated in EHPVO. Meso-Rex bypass is increasingly used to treat EHPVO in children.
  75. ncbi Management of inherited thrombophilia: guide for genetics professionals
    E A Varga
    Division of Hematology Oncology BMT, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Clin Genet 81:7-17. 2012
    ..This review will educate genetics professionals about inherited and acquired risk factors for VTE and discuss recommendations for management of asymptomatic individuals with thrombophilia.
  76. ncbi Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations
    C Boinot
    Laboratoire d Hématologie and Laboratoire de Génétique Cellulaire et Moléculaire, CHU La Miletrie, Poitiers, France
    Blood Coagul Fibrinolysis 14:191-6. 2003
    ..The present family study illustrates the concept of 'mild' mutation and the hypothesis that familial thrombophilia is a multifactorial disease.
  77. ncbi Mortality and inherited thrombophilia: results from the European Prospective Cohort on Thrombophilia
    I Pabinger
    Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Austria
    J Thromb Haemost 10:217-22. 2012
    Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies.
  78. ncbi Laboratory investigation of thrombophilia: the good, the bad, and the ugly
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
    Semin Thromb Hemost 35:695-710. 2009
    b>Thrombophilia can be broadly defined as an increased tendency toward hypercoagulability and venous thrombosis...
  79. ncbi External quality assessment and the laboratory diagnosis of thrombophilia
    Piet Meijer
    ECAT Foundation, Leiden, The Netherlands
    Semin Thromb Hemost 31:59-65. 2005
    ..58 x total biological variation). This study shows that a more stable performance of laboratory tests involved in the screening of thrombophilia over a prolonged period of time is necessary.
  80. ncbi Genetic thrombophilia
    W Gregory Feero
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, 03755, USA
    Prim Care 31:685-709, xi. 2004
    ..This article provides an overview of the genetics of thrombophilia. Specific information on the factor V Leiden mutation;the prothrombin G20210A mutation; and protein C, ..
  81. ncbi Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome. Hemolysis, elevated liver-enzymes, low platelets
    G F von Tempelhoff
    Thromb Res 100:363-5. 2000
  82. ncbi Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial
    Jantien Visser
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 105:295-301. 2011
    ..In more than half of all recurrent miscarriage the cause still remains uncertain. Thrombophilia has been identified in about 50% of women with recurrent miscarriage and thromboprophylaxis has been suggested ..
  83. ncbi Inherited thrombophilia in arterial disease: a selective review
    Philippe de Moerloose
    Hemostasis Unit, Department of Internal Medicine, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland
    Semin Hematol 44:106-13. 2007
    b>Thrombophilia may be defined as an acquired or congenital abnormality of hemostasis predisposing to thrombosis...
  84. ncbi Dynamic APTT parameters: applications in thrombophilia
    B Sørensen
    Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Guy s and St Thomas NHS Foundation and King s College London School of Medicine, London, UK
    J Thromb Haemost 10:244-50. 2012
    ..Patients with a history of venous thrombosis occasionally have shortened APTTs when compared with those of healthy references, but the clinical applicability of a shortened APTT is limited...
  85. ncbi Young Adult Myocardial Infarction and Ischemic Stroke: the role of paradoxical embolism and thrombophilia (The YAMIS Study)
    Sanjay Sastry
    Academic Surgery Unit, South Manchester University Hospital, Manchester, United Kingdom
    J Am Coll Cardiol 48:686-91. 2006
    ..frequency of venous-to-arterial circulation shunts (v-aCS), usually caused by patent foramen ovale (PFO), and thrombophilia in young adults suffering myocardial infarction (MI) and ischemic stroke (IS) and matched healthy control ..
  86. ncbi Diagnostic issues in thrombophilia: a laboratory scientist's view
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, New South Wales, Australia
    Semin Thromb Hemost 31:11-6. 2005
    b>Thrombophilia can be defined as an increased tendency to thrombosis. There are several defined risk factors for thrombosis, and these are generally separated into acquired and congenital factors...
  87. ncbi Inappropriate use of protein C, protein S, and antithrombin testing for hereditary thrombophilia screening: an experience from a large university hospital
    P Tientadakul
    Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Int J Lab Hematol 33:593-600. 2011
    ..Deficiencies of protein C, protein S, and antithrombin are the main inherited risk factors in Thai patients with venous thromboembolism, although the prevalence is not high...
  88. ncbi Frequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome
    Ovgu Ozkan Dogan
    Kadirli State Hospital, Osmaniye, Turkey
    J Obstet Gynaecol Res 37:527-33. 2011
    ..The purpose of this study was to investigate the correlations between thrombophilic mutations, anticoagulant activity and hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome...
  89. ncbi Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia
    A Many
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel Aviv, Israel
    Obstet Gynecol 98:1041-4. 2001
    To compare placental pathology between women with and without thrombophilia who had severe preeclampsia, intrauterine growth retardation, severe abruptio placentae, or stillbirth.
  90. ncbi Pathophysiology of venous thrombosis, thrombophilia, and the diagnosis of deep vein thrombosis-pulmonary embolism in the elderly
    Geno J Merli
    Division of Internal Medicine, Jefferson Antithrombotic Therapy Service, Thomas Jefferson University Hospital, Jefferson Medical College, Philadelphia, PA 19107, USA
    Clin Geriatr Med 22:75-92, viii-ix. 2006
    ..The second clinical point is the appropriate need to evaluate elderly patients for primary or secondary thrombophilia. By using statistical probability and clinical history selected geriatric patients with VTE should be assessed ..
  91. ncbi Protein S and protein C gene mutations in Japanese deep vein thrombosis patients
    Sachiko Kinoshita
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3 1 1 Maedashi Fukuoka 812 8582, Japan
    Clin Biochem 38:908-15. 2005
    ..Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population...
  92. ncbi X-linked thrombophilia with a mutant factor IX (factor IX Padua)
    Paolo Simioni
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
    N Engl J Med 361:1671-5. 2009
    We report a case of juvenile thrombophilia associated with a substitution of leucine for arginine at position 338 (R338L) in the factor IX gene (factor IX-R338L)...
  93. ncbi Thrombophilia testing in patients with venous thromboembolism. Findings from the RIETE registry
    Vanessa Roldan
    Department of Haematology and Clinical Oncology, Universidad de Murcia, Spain
    Thromb Res 124:174-7. 2009
    There is scarce information on the management habits with regard to thrombophilia testing in patients with venous thromboembolism (VTE).
  94. ncbi Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Clin Appl Thromb Hemost 10:323-34. 2004
    b>Thrombophilia, hypofibrinolysis, and polycystic ovary syndrome (PCOS) are associated with recurrent pregnancy loss (RPL) and spontaneous abortion (SAB) alone and concurrently...
  95. ncbi Genetic hypofibrinolysis in complicated pregnancies
    C J Glueck
    Cholesterol Center, Alliance Hospitals, Cincinnati, Ohio 45229, USA
    Obstet Gynecol 97:44-8. 2001
    ..To assess the hypofibrinolytic 4G/4G mutation of the plasminogen activator inhibitor (PAI-1) gene as a possible factor contributing to severe preeclampsia, abruptio placentae, fetal growth restriction, and stillbirth...
  96. ncbi Hypercoagulability in patients undergoing coronary artery bypass grafting: prevalence, patient characteristics and postoperative outcome
    Sulman Rafiq
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Cardiothorac Surg 41:550-5. 2012
    ....
  97. ncbi Thrombophilia and the risk of thromboembolic events in women on oral contraceptives and hormone replacement therapy
    Maria T Desancho
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    Blood Coagul Fibrinolysis 21:534-8. 2010
    b>Thrombophilia contributes to the risk of thrombosis in women using female hormones...
  98. ncbi Thrombophilia testing in patients with venous thrombosis
    J A Caprini
    Department of Surgery, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Eur J Vasc Endovasc Surg 30:550-5. 2005
    Routine thrombophilia testing is controversial because of the low yield of positive tests, costs involved, and debate about the clinical usefulness of the data obtained from testing...
  99. ncbi Hemodialysis, erythropoietin and megakaryocytopoiesis: factors in uremic thrombocytopathy and thrombophilia
    J J Zwaginga
    Department of Hematology, Academical Medical Center, Department of Experimental Immunohematology, Sanquin Research at CLB, Amsterdam, The Netherlands
    J Thromb Haemost 2:1272-4. 2004
  100. ncbi Embryo implantation after assisted reproductive procedures and maternal thrombophilia
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Via Pace, 9, 20122 Milano, Italy
    Haematologica 88:789-93. 2003
    ..of failure of embryo implantation might be an impairment of the uteroplacental circulation due to hypercoagulability in the mother, we investigated the association between thrombophilia and failure to achieve pregnancy after IVF or ICSI.
  101. ncbi Prevalence of inherited thrombophilia in young thrombosis patients from the East Bohemian region
    P Dulícuek
    Department of Hematology, University Hospital, Hradec Kralove, Czech Republic
    Blood Coagul Fibrinolysis 13:569-73. 2002
    ..Inherited thrombophilia may result in a hypercoagulable state that causes an increased tendency to thrombosis...

Research Grants62

  1. NEWBORN SCREENING BY MULTIPLEX MOLECULAR ANALYSIS
    Edwin Naylor; Fiscal Year: 2002
    ..Alpha-1-Antitrypsin Deficiency Z allele (G9989a) and S allele (A7677T); 4). Hereditary Thrombophilia (Factor V Leiden G1691A, Prothrombin G20210A, Methylenetetrahydrofolate reductase C677T); 5)...
  2. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..We have developed a murine model of thrombophilia-precipitated placental failure and fetal loss that occurs in the absence of thrombosis...
  3. Research on the Scope and Causes of Stillbirth in the US
    Carol Hogue; Fiscal Year: 2009
    ..A concept proposal, "The association of stillbirths with maternal and fetal thrombophilia genotypes," is presented...
  4. Prevention of Complications in Hemophilia Through HTCs
    Marilyn J Manco Johnson; Fiscal Year: 2010
    ..proposal is to continue the direct patient care family-centered, community-based comprehensive hemophilia and thrombophilia services by supporting the successful existing structure of the five Hemophilia Treatment Centers (HTCs) in ..
  5. Region VII Hemophilia Program
    Brian M Wicklund; Fiscal Year: 2010
    ..and lay organizations such as the National Hemophilia Foundation and the National Alliance for Thrombosis and Thrombophilia, the regional project looks at the hypothesis that with increased physical activity, persons with hemophilia ..
  6. Duke - UNC Clinical Hematology and Transfusion Research Career Development Progra
    Marilyn J Telen; Fiscal Year: 2013
    ..that are well established strengths of our medical center, namely: (1) Sickle Cell Disease;(2) Thrombosis and Thrombophilia;(3) Disorders of Hemostasis;and (4) Transfusion Medicine, Anemia, and Stem Cell Therapy...
  7. Preventing Bleeding Disorder Complications thru Hemophilia Tx Ctrs in Region IX
    Diane J Nugent; Fiscal Year: 2010
    ..data related to women's ssues in coagulation, rare bleeding disorders, prophylaxis, factor utilization, thrombophilia, inhibitors, and other important clinical outcomes;(5) Design and pilot additional studies aimed at further ..
  8. Regulation of transcription termination and its link in mRNA surveillance
    Chi Ming Wong; Fiscal Year: 2013
    ..surprising that transcription termination defects are causally associated with various human diseases, such as thrombophilia, thalassemia and cancer...
  9. Pediatric Heart Network - The Hospital for Sick Children, Toronto
    Steven M Schwartz; Fiscal Year: 2013
    ..at the time of initial presentation and diagnosis, and randomized to prasugrel or dabigatrin after baseline thrombophilia and genetics assessment...
  10. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ..Abstract) Epidemiologic studies have identified Factor V Leiden as the most common cause of heritable thrombophilia a prothrombotic mutation associated with a 5 to 7-fold increase in the risk of venous thromboembolism (VTE)...
  11. Genetic Variation in Factor IX and Thrombosis Risk
    TOM HOWARD; Fiscal Year: 2006
    ..Recent discoveries from the Genetics Analysis of Idiopathic Thrombophilia (GAIT) Project demonstrate that: 1) the population variation in thrombosis risk has a high heritability (h2), ..
  12. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2007
    ..is the delineation of novel pathogenic mechanisms underlying adverse pregnancy outcome associated with thrombophilia. Our work in the context of the parent proposal to study the function of the blood clotting regulator ..
  13. FACTOR V GENE DEFECTS IN THROMBOPHILIA
    WILLIAM KANE; Fiscal Year: 2001
    ..This information will provide important insights into the pathophysiology of APC resistance and thrombosis and may ultimately lead to novel strategies for antithrombotic therapy. ..
  14. Integrating Prevention Services for Bleeding & Clotting
    Claire Philipp; Fiscal Year: 2006
    ..The goals of this project are to integrate Thrombophilia, Women with Bleeding Disorders, and comprehensive Hemophilia care programs under an organizational umbrella ..
  15. Decidual-Endothelial Tissue Factor and IUGR
    Charles Lockwood; Fiscal Year: 2006
    ..2) Employ a murine model of the Factor V Leiden mutation to determine whether Inherited thrombophilia induced uteroplacental thrombosis is associated with induction of decidual endothelial cell TF and whether ..
  16. Immuno Biosensor for Real-Time Factor V Leiden Diagnosis
    KYUNG KANG; Fiscal Year: 2005
    ..DNA analysis), and less expensive, and also provide the information on the degree of thrombophilia by having the amount of both FVN and FVL...
  17. Genetic Risk Factors for CVA in Children with Hb SS
    Abdullah Kutlar; Fiscal Year: 2004
    ..This study will determine if common genetic polymorphisms associated with thrombophilia are important risk factors for the development of cerebrobvascular disease and stroke in these children...
  18. MOLECULAR GENETIC STUDY OF VONWILLEBRAND FACTOR
    David Ginsburg; Fiscal Year: 2010
    ..The results of these studies should offer new insight into the biology of endothelial cell function and VWF biosynthesis and may also lead to improved diagnosis and therapy for VWD and thrombophilia.
  19. Integrated Program for Persons with Hemostatic Disorders
    Thomas Ortel; Fiscal Year: 2006
    ..for persons with hemophilia, other hereditary bleeding disorders including women with bleeding disorders, and thrombophilia to reduce morbidity and mortality associated with bleeding and clotting diseases...
  20. Integrating Prevention Services for Bleeding & Clottiing
    Marilyn Manco Johnson; Fiscal Year: 2006
    ..Using this same model of care with specialists in multiple disciplines, services to the thrombophilia & thrombosis population as well as women with bleeding began in 2001...
  21. Diagnosing DNA Mutations Using Mismatch Repair Enzymes
    LEONARD BAZAR; Fiscal Year: 2004
    ..virus (HPV) and the Coagulation factor V Leiden mutation, which are associated with cervical cancer and thrombophilia, respectively...
  22. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..
  23. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Among those with hereditary disorders associated with the hypercoagulable state ("hereditary thrombophilia") there will be an increased risk of deep functional venous disease (DFD) assessed by duplex ultrasound and of ..
  24. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  25. Role of Coagulation System Variability: Cardiac Surgery
    Brian Donahue; Fiscal Year: 2006
    ..The project will make extensive use of data in the Vanderbilt Cardiac Surgery Registry, a valuable database of genetic and clinical data presently being prospectively collected on elective adult cardiac surgery patients...
  26. Complement as a Mediator of Recurrent Miscarriages
    Jane Salmon; Fiscal Year: 2008
    ..In addition, our studies will provide insights into mechanisms by which complement-induces disease and suggest means to prevent, arrest, or modify complement-mediated inflammatory disorders. [unreadable] [unreadable]..
  27. COAGULATION ACTIVATION IN SICKLE CELL DISEASE
    Kenneth I Ataga; Fiscal Year: 2010
    ..abstract_text> ..
  28. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  29. Targets for New Therapeutics for SLE
    Jane Salmon; Fiscal Year: 2002
    ..abstract_text> ..
  30. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    ..Additionally, understanding how aPL antibodies "cause" pregnancy loss may translate into new concepts about maternal-fetal tolerance and miscarriages in general and benefit women with non-APS- related pregnancy complications. ..
  31. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
  32. Improving use of peri-operative beta-blockers with a multidimentional QI program
    Andrew Auerbach; Fiscal Year: 2009
    ..The impact of this set of tools will be substantial as groups such as the NSQIP, SCIP, National Quality Forum, and Leapfrog Group continue to endorse PBB as a key strategy to reduce surgical morbidity and mortality. ..
  33. Prenatal diagnosis through selective DNA amplification
    Stephen Brown; Fiscal Year: 2009
    ..When and if such methods become available, they will revolutionize prenatal diagnosis and will represent a major milestone in the improvement of prenatal care. ..
  34. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    ..abstract_text> ..
  35. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2009
    ....
  36. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul J Mills; Fiscal Year: 2010
    ..abstract_text> ..
  37. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
  38. UCSD Hillcrest Flow Cytometer
    Paul Mills; Fiscal Year: 2003
    ..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
  39. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS-DCC
    Robert Glynn; Fiscal Year: 2002
    ..Events will be assessed by yearly visits and bi-monthly questionnaires at the time of the INR monitoring. ..
  40. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  41. GENETIC STUDIES OF ANEURYSMAL SUBARACHNOID HEMORRHAGE
    Mark Alberts; Fiscal Year: 2003
    ..This research project combined with the PI's background and expertise provide a wide range of patient-oriented mentorship opportunities in clinical and genetic research...
  42. The impact of early antiretroviral therapy on HIV persistence and inflammation
    STEVEN GRANT DEEKS; Fiscal Year: 2010
    ..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
  43. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2009
    ..This proposal will provide insights into the mechanisms of lineage-selection during mast cell development and may lead to therapeutic targets for mast cell-related diseases. ..
  44. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2008
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
  45. MANAGEMENT OF PATIENTS WITH SUSPECTED PULMONARY EMBOLISH
    Suman Rathbun; Fiscal Year: 2005
    ..abstract_text> ..
  46. Role of 10-formyldihydrofolate in purine biosynthesis
    Tsunenobu Tamura; Fiscal Year: 2004
    ..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..
  47. MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT
    Emily Von Scheven; Fiscal Year: 2005
    ..Furthermore, development of this well characterized SLE cohort will serve as an important future resource and builds a foundation for studying many lifelong effects of childhood-onset SLE. ..
  48. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  49. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2004
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  50. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  51. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
    ....
  52. Functional Tissue Factor on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2004
    ....
  53. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2007
    ..We have established a system to study phospholipids-driven macromolecular complex formation, which may be a model for the generation of complexes that form extra-and intra-cellularly. ..
  54. Medication Use, Comorbidity and Outcomes in Aging populations
    Robert Glynn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  55. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2008
    ..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
  56. AT1 Receptor Activating Autoantibodies and Preeclampsia
    Yang Xia; Fiscal Year: 2008
    ..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
  57. IMMUNOLOGY OF HUMAN PLATELETS (HIV-1-ITP)
    Simon Karpatkin; Fiscal Year: 2007
    ..4. Determine whether anti-GPIIla49-66 is a result of molecular mimicry with antigen of infectious origin or its products. ..
  58. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2008
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. [unreadable] [unreadable] [unreadable]..
  59. Adenosine Signaling and Priapsim
    Yang Xia; Fiscal Year: 2008
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. [unreadable] [unreadable] [unreadable]..
  60. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....