eosinophilia

Summary

Summary: Abnormal increase in eosinophils in the blood, tissues or organs.

Top Publications

  1. ncbi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
  2. pmc The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice
    Bit Na Kang
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1179-91. 2012
  3. pmc Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines
    Cara J Bossley
    The Royal Brompton and Harefield NHS Trust, London, UK
    J Allergy Clin Immunol 129:974-82.e13. 2012
  4. ncbi Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
  5. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
  6. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
  7. ncbi CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
    Animesh Pardanani
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 102:3093-6. 2003
  8. ncbi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
  9. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
  10. ncbi Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus
    Juan Antonio Figueroa Castillo
    Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, 04510, Mexico, D F, Mexico
    Vet Parasitol 177:339-44. 2011

Detail Information

Publications360 found, 100 shown here

  1. ncbi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..of mepolizumab, a monoclonal antibody against interleukin-5, in a rare subgroup of patients who have sputum eosinophilia and airway symptoms despite continued treatment with prednisone...
  2. pmc The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice
    Bit Na Kang
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1179-91. 2012
    ....
  3. pmc Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines
    Cara J Bossley
    The Royal Brompton and Harefield NHS Trust, London, UK
    J Allergy Clin Immunol 129:974-82.e13. 2012
    ..The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood...
  4. ncbi Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
    ..affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known causes for eosinophilia (eg, drug reactions, parasitic infections, and malignancy)...
  5. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
    ..Under multivariate analysis with logistic regression, post-IVIG eosinophilia [peripheral blood (PB) eosinophils >or=4%] had an inverse correlation to KD patients with IVIG-resistance (p = ..
  6. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
    ..Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma...
  7. ncbi CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
    Animesh Pardanani
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 102:3093-6. 2003
    ..CHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia. Deletion of this locus and expression of the FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) ..
  8. ncbi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
    To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city.
  9. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
    ..We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling...
  10. ncbi Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus
    Juan Antonio Figueroa Castillo
    Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, 04510, Mexico, D F, Mexico
    Vet Parasitol 177:339-44. 2011
    ..contortus...
  11. ncbi Natural killer cells accumulate in lung-draining lymph nodes and regulate airway eosinophilia in a murine model of asthma
    C Ple
    INSERM, Institut National de la Santé et de la Recherche Médicale U774, Lille, France
    Scand J Immunol 72:118-27. 2010
    ..Anti-ASGM1 antibody treatment depleted most NK cells and decreased bronchoalveolar lavage eosinophilia but did not modify airway responsiveness...
  12. ncbi Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview
    Paul R J Ames
    Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom
    Clin Appl Thromb Hemost 16:628-36. 2010
    ..In addition, antineutrophil cytoplasmic antibodies may shift the endothelial lining to proadhesive and prothrombotic surface. It is hoped that the review will represent a basis to foster novel research on this topic...
  13. ncbi Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
    Ulaganathan Mabalirajan
    Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma and Lung Disease, Institute of Genomics and Integrative Biology, Delhi, India
    J Allergy Clin Immunol 125:626-35. 2010
    ....
  14. pmc The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia
    Ting Wen
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 188:1075-82. 2012
    ..Our findings identify a novel expression pattern and tissue eosinophilia-regulating function for the "B cell-specific" inhibitory molecule CD22 on GI eosinophils.
  15. pmc Evidence for distinct histologic profile of nasal polyps with and without eosinophilia
    Spencer C Payne
    Division of Rhinology and Sinus Surgery, Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Laryngoscope 121:2262-7. 2011
    To evaluate the histology, RNA, and protein signatures of nasal polyps (NPs) in order to demonstrate specific subtypes of disease and differentiate "idiopathic" NPs based on tissue eosinophilia.
  16. ncbi Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome
    Sébastien Savard
    Division of Nephrology, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec Hospital, and Faculty of Medicine, Laval University, Quebec, Canada
    Am J Kidney Dis 54:e17-20. 2009
    ..On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis...
  17. ncbi Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts
    Paulo Ricardo Criado
    Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    An Bras Dermatol 87:435-49. 2012
    The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic ..
  18. ncbi Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease
    Yukiko Iino
    Department of Otolaryngology, Jichi Medical University, Saitama Medical Center, Omiya ku, Japan
    Auris Nasus Larynx 38:456-61. 2011
    ..We aimed to investigate the clinical risk factors of EOM and to establish the diagnostic criteria of EOM...
  19. ncbi Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006
    ..The mast cell chemotactic activity of airway secretions has not been assessed in patients with eosinophilic bronchitis...
  20. ncbi Eosinophilic esophagitis
    Richard J Noel
    N Engl J Med 351:940-1. 2004
  21. pmc Toxocariasis and ingestion of raw cow liver in patients with eosinophilia
    Dongil Choi
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Korean J Parasitol 46:139-43. 2008
    ..We evaluated the relationship between toxocariasis and the ingestion of raw meat in patients with eosinophilia of unknown etiology...
  22. ncbi The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug
    Yoko Kano
    Department of Dermatology, Kyorin University School of Medicine, 6 20 2 Shinkawa Mitaka, Tokyo 181 8611, Japan
    Immunol Allergy Clin North Am 29:481-501. 2009
    Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, ..
  23. ncbi Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production
    Mee Rhan Kim
    Departments of Functional Genomics, Pathology, Inflammation, Clinical Immunology, and Protein Science, Amgen Inc, Thousand Oaks, California 91302, USA
    Blood 100:2330-40. 2002
    ..The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses...
  24. ncbi TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
    J Moisan
    Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 290:L987-95. 2006
    ..These results clearly demonstrate the anti-inflammatory effect of imidazoquinolines in an allergic asthma model as well as the clinical potential of TLR7 ligands in the treatment of allergic diseases...
  25. ncbi Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    G J Braunstahl
    Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Allergy Clin Immunol 107:469-76. 2001
    ..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
  26. pmc Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants
    Keir M Balla
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0380, USA
    Blood 116:3944-54. 2010
    ..Chronic exposure to helminth- related allergens resulted in profound eosinophilia, demonstrating that eosinophil responses to allergens have been conserved over evolution...
  27. pmc Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
    M M Walker
    Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College, London, UK
    Aliment Pharmacol Ther 29:765-73. 2009
    ..Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function...
  28. ncbi Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
    Alex Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    Gastroenterology 125:1660-9. 2003
    ..Before this study, the natural course of eosinophilic esophagitis had not been defined and information regarding potential long-term risks was lacking...
  29. ncbi IL-5 and eosinophilia
    Kiyoshi Takatsu
    Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama 930 0194, Japan
    Curr Opin Immunol 20:288-94. 2008
    ..IL-5Ralpha expression in B cells, but not in eosinophils is regulated by Oct-2. Eosinophilia is associated with a wide variety of conditions, including asthma and atopic diseases, helminth infections, ..
  30. ncbi IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 120:1292-300. 2007
    ..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal ..
  31. ncbi Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
    During the last decade, clinical practice saw a rapid increase of patients with esophageal eosinophilia who were thought to have gastroesophageal reflux disease (GERD) but who did not respond to medical and/or surgical GERD management...
  32. ncbi Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related
    David W Reid
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 13:799-809. 2008
    ..In particular, it is not known whether BDR is associated with underlying airway eosinophilia and whether BDR is predictive of a better response to inhaled corticosteroid (ICS) treatment.
  33. ncbi Predicting sputum eosinophilia in exacerbations of COPD using exhaled nitric oxide
    Szabolcs Soter
    Department of Pulmonology, National Koranyi Institute of TB and Pulmonology, Pihenô út 1, 1121, Budapest, Hungary
    Inflammation 36:1178-85. 2013
    ..increase in forced expiratory volume in one second (FEV(1)) after treatment was greater in patients with sputum eosinophilia (ΔFEV(1) 0.35 ± 0.12 vs. 0.13 ± 0.04 L, p = 0...
  34. ncbi Unsuspected strongyloidiasis in hospitalised elderly patients with and without eosinophilia
    M Pirisi
    Department of Medical Sciences, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy
    Clin Microbiol Infect 12:787-92. 2006
    ..In conclusion, strongyloidiasis was relatively common among elderly in-patients; eosinophilia and a history of farm work were the most useful indications for this diagnosis.
  35. pmc Pulmonary inflammation induced by a recombinant Brugia malayi gamma-glutamyl transpeptidase homolog: involvement of humoral autoimmune responses
    A S Gounni
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    Mol Med 7:344-54. 2001
    ..from the lymphatic filarial parasite Brugia malayi implicated in the pathogenesis of tropical pulmonary eosinophilia (TPE) has recently been cloned and identified as the homolog of the membrane-bound mammalian enzyme gamma-..
  36. ncbi Acute lymphocytic leukemia with eosinophilia and unusual karyotype
    S Rezk
    Leuk Lymphoma 47:1176-9. 2006
  37. ncbi Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2)
    Y Kim
    Division of Pulmonary and Critical Care Medicine, and Division of Rheumatology and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 166:5183-92. 2001
    ..OVA-challenged CCR2(-/-) mutants also were also found to have enhanced bronchoalveolar lavage fluid eosinophilia, peribronchiolar cellular cuffing, and Ig subclass switching, with increase in OVA-specific IgG(1) and IgE...
  38. ncbi Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma
    L Jayaram
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Ave E, Hamilton, ON L8N 4A6, Canada
    Eur Respir J 25:41-6. 2005
    Sputum eosinophilia is a sensitive predictor of benefit from corticosteroid treatment. Montelukast is a cysteinyl leukotriene antagonist, which also reduces sputum and blood eosinophils...
  39. ncbi Development of chronic airway obstruction in patients with eosinophilic bronchitis: a prospective follow-up study
    Sung Woo Park
    Asthma and Allergy Research Group, Soonchunhyang University Hospital, Bucheon, Korea
    Chest 125:1998-2004. 2004
    Eosinophilic bronchitis (EB) presents as a chronic cough and sputum eosinophilia without airflow limitation or bronchial hyperreactivity. Its long-term clinical course remains unknown...
  40. ncbi Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics
    H Z Shi
    Department of Internal Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning, People s Republic of China
    Am J Respir Crit Care Med 157:204-9. 1998
    In order to investigate the role of interleukin-5 (IL-5) in airway hyperreactivity and eosinophilia, we observed the effect of inhaled recombinant human IL-5 on airway responsiveness to methacholine and cell populations in induced sputum ..
  41. ncbi Eosinophilia during intestinal infection
    Thomas Loscher
    Department of Infectious Diseases and Tropical Medicine, Ludwig Maximilians University of Munich, Leopoldstrasse 5, Munich, Germany
    Best Pract Res Clin Gastroenterol 22:511-36. 2008
    b>Eosinophilia is a common finding in tropical developing countries, and is mainly caused by chronic helminth infections, predominantly of the gut...
  42. pmc Seroprevalence of toxocariasis among healthy people with eosinophilia
    Yong Hun Kim
    Department of Parasitology, College of Medicine, Hallym University, Chuncheon, Republic of Korea
    Korean J Parasitol 46:29-32. 2008
    The aim of this study is to determine the Toxocara seropositive rate among healthy people with eosinophilia. A total of 97 people residing in Seoul who were healthy and whose blood eosinophilia was over 10%, as shown by regular health ..
  43. doi Eosinophilia with FIP1L1-PDGFRA fusion in a patient with chronic myelomonocytic leukemia
    Victor Zota
    Department of Pathology, University of Massachusetts Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
    J Clin Oncol 26:2040-1. 2008
  44. ncbi Clinical features and outcomes of eosinophilic myocarditis patients treated with prednisolone at a single institution over a 27-year period
    Sayaka Kawano
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan
    Intern Med 50:975-81. 2011
    Eosinophilic myocarditis is a rare clinical entity characterized by eosinophilia and myocardial inflammation with infiltrating eosinophils...
  45. pmc A seroepidemiological survey of toxocariasis among eosinophilia patients in Chungcheongnam-do
    Min Seo
    Department of Parasitology, College of Medicine, Dankook University, Cheonan 330 714, Korea
    Korean J Parasitol 50:249-51. 2012
    There have been several reports on the relationship between toxocariasis and eosinophilia, but all have been limited to the areas of Seoul or Gangwon-do...
  46. ncbi Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1)
    M Broekema
    Dept of Pathology, University of Groningen, Groningen, The Netherlands
    Respir Med 104:1254-62. 2010
    ..As it is unknown whether complete asthma remission or progression of asthma is associated with airway inflammation and remodeling, we assessed these characteristics in bronchial biopsies of relevant subsets of asthma patients...
  47. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
    ..baumannii in modulating airway eosinophilia in a mouse model of allergic asthma. Ovalbumin (OVA)-sensitized mice were treated with live A...
  48. pmc IL-33 promotes eosinophilia in vivo and antagonizes IL-5-dependent eosinophil hematopoiesis ex vivo
    Kimberly D Dyer
    Inflammation Immunobiology Section of the Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Immunol Lett 150:41-7. 2013
    IL-33 is an IL-1 family cytokine that elicits IL-5-dependent eosinophilia in vivo...
  49. ncbi Cerebrospinal fluid eosinophilia associated with intraventricular shunts
    Sofia Bezerra
    Grupo de Parasitologia Biomédica da PUCRS, Avenida Ipiranga 6690, 90690 900 Porto Alegre, RS, Brazil
    Clin Neurol Neurosurg 113:345-9. 2011
    CSF eosinophilia (CSF-eo) is uncommon and is usually caused by helminthic infections. However, it has also been found in ∼30% of patients experiencing intraventricular shunt malfunctions...
  50. ncbi Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
    E A Garcia-Zepeda
    Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Med 2:449-56. 1996
    ..To determine whether a similar molecule might play a role in human inflammatory diseases characterized by eosinophilia, we isolated the human eotaxin gene...
  51. pmc Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia
    Mari Kogiso
    Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431 0991, USA
    J Leukoc Biol 90:167-76. 2011
    ..p. administration of LCB or Sephadex beads induced within 24 h a CRTH2-dependent peritoneal eosinophilia, as well as CRTH2-independent activation of peritoneal Mϕ that expressed Arg I, an M2 phenotype...
  52. pmc Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset
    John M Coleman
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC UPSOM, Pittsburgh, PA 15213, USA
    Thorax 67:1061-6. 2012
    ..However, the epithelial and bronchoalveolar lavage (BAL) cell expression of these chemokines in relation to asthma severity and eosinophilic phenotypes has not been addressed...
  53. pmc Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model
    Pierre Olivier Girodet
    Centre de Recherche Cardio Thoracique de Bordeaux, U1045, U1034, De partement de Pharmacologie, CIC 0005, University of Bordeaux, Bordeaux, France
    Am J Respir Cell Mol Biol 48:212-9. 2013
    ..treatment with TRAM-34 abolishes BSM remodeling and subbasement collagen deposition, and attenuates airway eosinophilia. Although curative treatment alone did not significantly reduce BHR, the combined treatment attenuated ..
  54. ncbi Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management
    Anna M Checkley
    Hospital for Tropical Diseases, Capper Street, London WC1E6JB, UK
    J Infect 60:1-20. 2010
    b>Eosinophilia is a common finding in returning travellers and migrants, and in this group it often indicates an underlying helminth infection...
  55. ncbi IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6)
    G B Huffnagle
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 160:2393-400. 1998
    ..The role of IL-5 in promoting the pulmonary eosinophilia and subsequent inflammatory damage in susceptible C57BL/6 mice was investigated...
  56. ncbi Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals
    Kittisak Sawanyawisuth
    The Research and Diagnostic Centre for Emerging Infectious Disease, Khon Kaen University, Khon Kaen, Thailand
    Mem Inst Oswaldo Cruz 105:942-4. 2010
    ..6%, 80.2%, 58.1% and 90.5%, respectively. These data support the use of testing for high blood eosinophil levels as a diagnostic tool for MA in individuals that are at risk for this disease...
  57. pmc Recurrent blood eosinophilia in ulcerative colitis is associated with severe disease and primary sclerosing cholangitis
    Arthur Barrie
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Dig Dis Sci 58:222-8. 2013
    ..A subset of IBD patients develops blood eosinophilia, and the clinical profile of these patients is undefined...
  58. ncbi Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease
    Victor Matheu
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, BMC 111, Lund 22184, Sweden
    J Allergy Clin Immunol 112:585-92. 2003
    ..A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated...
  59. pmc High rate of strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections
    Silvia A Repetto
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires
    Am J Trop Med Hyg 82:1088-93. 2010
    ..We used direct fresh stool examination, Ritchie's method, and agar plate culture for diagnosis in patients with eosinophilia and previous residence in endemic areas...
  60. ncbi Eosinophilia and the seroprevalence of schistosomiasis and strongyloidiasis in newly arrived pediatric refugees: an examination of Centers for Disease Control and Prevention screening guidelines
    Elizabeth E Dawson-Hahn
    Department of Pediatrics, Hasbro Children s Hospital, Providence, RI, USA
    J Pediatr 156:1016-8, 1018.e1. 2010
    ..Our study revealed that eosinophilia was not predictive of serologic evidence of either a Schistosoma species or Strongyloides stercoralis infection ..
  61. ncbi Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure
    Majed Eshki
    Department of Dermatology, Bichat Claude Bernard Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France
    Arch Dermatol 145:67-72. 2009
    Factors implicated in the severity of drug reaction with eosinophilia and systemic symptoms (DRESS) have not been identified...
  62. ncbi [Management of drug reaction with eosinophilia and systemic symptoms (DRESS)]
    V Descamps
    Hopital Bichat, AP HP, Paris, France
    Ann Dermatol Venereol 137:703-8. 2010
    The management of drug-induced hypersensitivity syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS) is not codified...
  63. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
    ..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...
  64. ncbi PGE(2) decreases muscle cell proliferation in patients with non-asthmatic eosinophilic bronchitis
    Beatriz Sastre
    Immunology Department, IIS Fundación Jiménez Díaz, Madrid, Spain
    Prostaglandins Other Lipid Mediat 95:11-8. 2011
    Non-asthmatic eosinophilic bronchitis (NAEB) is characterized by chronic cough and sputum eosinophilia without bronchial hyperresponsiveness...
  65. ncbi Disseminated colon cancer with severe peripheral blood eosinophilia and elevated serum levels of interleukine-2, interleukine-3, interleukine-5, and GM-CSF
    George K Anagnostopoulos
    J Surg Oncol 89:273-5. 2005
  66. ncbi Severe acute hepatitis in the DRESS syndrome: Report of two cases
    Sabela Lens
    Institut de Malalties Digestives, Hospital Clinic, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Ann Hepatol 9:198-201. 2010
    The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, also known as DIHS (drug-induced hypersensitivity syndrome), is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can ..
  67. pmc IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis
    Todd M Wilson
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    J Allergy Clin Immunol 128:1086-92.e1-3. 2011
    IL-5 plays a central role in the development and maintenance of eosinophilia (EO) and eosinophil activation in a wide variety of eosinophilic disorders...
  68. ncbi Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals
    K P Lan
    Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    J Helminthol 78:311-7. 2004
    ..Although eosinophilia is an important clinical manifestation of A...
  69. ncbi Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine
    Tulio Queto
    Laboratório de Fisiopatologia Humana, IFF, FIOCRUZ, Rio de Janeiro, Brazil
    Am J Respir Crit Care Med 181:429-37. 2010
    The mechanism of action of diethylcarbamazine (DEC), an antifilarial drug effective against tropical pulmonary eosinophilia, remains controversial. DEC effects on microfilariae depend on inducible NO synthase (iNOS)...
  70. ncbi Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation
    M Mennicke
    University Clinic for Visceral Surgery and Medicine, Bern University Hospital, and University of Bern, Switzerland
    Am J Transplant 9:2197-202. 2009
    DRESS syndrome (drug rash with eosinophilia and systemic symptoms) is a rare drug hypersensitivity reaction with a significant mortality...
  71. ncbi Prevalence of allergic rhinitis and nasal smear eosinophilia in 11- to 15 yr-old children in Shiraz
    Sara Miri
    Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Pediatr Allergy Immunol 17:519-23. 2006
    ..The objective of this study was to determine the prevalence of nasal symptoms and signs of AR and nasal smear eosinophilia in 11- to 15-yr-old children in Shiraz...
  72. pmc Practical approach to the patient with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:39-44. 2010
    Markedly increased blood eosinophilia (ie, > or =1.5 x 10(9)/L), whether discovered fortuitously or found with signs and symptoms of associated organ involvement, commands diagnostic evaluation and often therapeutic interventions...
  73. ncbi First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis
    Guillaume Roquin
    Service d Hepato gastro enterologie, CHU Angers, Angers, France
    Ann Pharmacother 44:1998-2000. 2010
    To report a case of lamotrigine-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome with pancreatitis as the initial visceral involvement.
  74. ncbi Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
    C E Brightling
    Glenfield Hospital, Leicester, United Kingdom and Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 162:878-82. 2000
    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but in contrast to asthma there is no variable airflow obstruction or airway hyperresponsiveness...
  75. ncbi A presumptive case of toxocariasis associated with eosinophilic pleural effusion: case report and literature review
    Mahi Lakshmi Ashwath
    Department of Internal Medicine, Section of Infectious Diseases, Mercer University School of Medicine, Macon, Georgia 31201, USA
    Am J Trop Med Hyg 71:764. 2004
    ..The symptoms of this patient responded promptly to a nonsteroidal anti-inflammatory medication (naproxen). This is only the fourth reported case of a pleural effusion associated with Toxocara...
  76. ncbi The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait
    M Khadadah
    Department of Medicine, Faculty of Medicine, Kuwait University, Safat
    J Asthma 37:481-8. 2000
    There is evidence that elevated serum immunoglobulin E (IgE) and eosinophilia correlate well with allergic skin test reactivity. These parameters have been used as alternative methods to characterize atopic subjects...
  77. ncbi Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
    Hiromi Okigami
    Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Disease Research, Japan
    Eur J Pharmacol 559:202-9. 2007
    ..These data support the use of small molecule VLA-4 antagonists in the treatment of relevant diseases, such as asthma, atopic dermatitis, or allergic rhinitis...
  78. pmc Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract
    Dagmar Simon
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 126:3-13; quiz 14-5. 2010
    ..An approach to determining the causal role of eosinophils in these diseases is presented. Recent findings concerning molecular diagnosis, cause, and treatment are discussed...
  79. pmc Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update
    Ayalew Tefferi
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 85:158-64. 2010
    Acquired eosinophilia is operationally categorized into secondary, clonal, and idiopathic types. Causes of secondary eosinophilia include parasite infections, allergic or vasculitis conditions, drugs, and lymphoma...
  80. ncbi Eosinophilic esophagitis: it's not just kid's stuff
    Victor L Fox
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 56:260-70. 2002
  81. ncbi Retrospective analysis of drug-induced hypersensitivity syndrome: a study of 27 patients
    Chia Chun Ang
    Department of Dermatology, Changi General Hospital, Singapore
    J Am Acad Dermatol 63:219-27. 2010
    ..Previous reports regarding the characteristics of patients with drug-induced hypersensitivity syndrome (DIHS) are mostly limited to small case reports and drug-specific case series, mainly involving Caucasian patients...
  82. ncbi Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges
    F Taki
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Exp Allergy 37:599-607. 2007
    ..It is generally considered that eosinophilic inflammation and hyper-reactivity to methacholine in airways are fundamental to the pathophysiology of bronchial asthma...
  83. ncbi The comparision of IgG antibodies specific to Toxocara spp. among eosinophilic and non-eosinophilic groups
    Senem Yaman Karadam
    Adnan Menderes University, Medical School Department of Microbiology and Clinical Microbiology, Aydin, Turkey
    New Microbiol 31:113-6. 2008
    Toxocariasis is one of the most frequently reported helminth infections worldwide. Eosinophilia is a common finding of parasitic infections. This study assessed the levels of IgG antibodies specific to Toxocara spp...
  84. ncbi Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis
    B Sastre
    Immunology Department Fundación Jiménez Díaz Capio, CIBERES ISCIII, Madrid, Spain
    Allergy 63:58-66. 2008
    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness...
  85. ncbi Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbumin
    Xiaobing Han
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Eur J Immunol 34:981-9. 2004
    ..Moreover, adoptive transfer of iIDC, but not iNDC, could inhibit systemic and local eosinophilia induced by allergen exposure...
  86. ncbi Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment
    Ayalew Tefferi
    Department of Internal Medicine and Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:75-83. 2005
    Acquired blood eosinophilia is considered either a primary or a secondary phenomenon...
  87. ncbi Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis
    Shweta Saxena
    Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, India
    J Allergy Clin Immunol 111:1001-7. 2003
    ..Studies from our group have shown a protective role of pulmonary surfactant protein A (SP-A) against lung allergy and infections caused by Aspergillus fumigatus...
  88. ncbi Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection
    Elizabeth S Magalhães
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    FASEB J 23:1262-71. 2009
    ..of inflammatory diseases, including asthma, in which it enhances airway hypersensitivity and tissue eosinophilia. Herein, we investigated the role of MIF in eosinophilopoiesis and tissue eosinophilia using Schistosoma ..
  89. ncbi Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  90. ncbi Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T6741 mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy
    Hiroaki Ohnishi
    Br J Haematol 134:547-9. 2006
  91. ncbi Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis
    Amir F Kagalwalla
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1097-102. 2006
    ..However, compliance with an exclusive, poor-tasting liquid formulation is difficult...
  92. pmc Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?
    Fouad El Sayed
    Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon
    Head Face Med 2:32. 2006
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region...
  93. pmc The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:7958-68. 2008
    ..respiratory syncytial virus (FI-RSV) vaccine experienced enhanced respiratory disease, including pulmonary eosinophilia, after contracting a natural RSV infection...
  94. ncbi Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways
    Atsuko Kibe
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Crit Care Med 167:50-6. 2003
    ..Control of steroid-resistant features induced by IL-13, including AHR and mucus production, may provide new therapeutic modalities for asthma...
  95. ncbi Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...
  96. ncbi Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking
    S A Walsh
    Department of Dermatology, King s College Hospital, Denmark Hill, London, UK
    Clin Exp Dermatol 36:6-11. 2011
    Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a severe medication-induced adverse reaction, which has cutaneous, haematological and solid-organ features...
  97. pmc TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection
    Mingjian Fei
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 108:5360-5. 2011
    ..Our study identifies TNF-α as a molecular switch that orchestrates a sequence of events in DCs and CD4 T cells that promote neutrophilic airway inflammation...
  98. ncbi Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma
    Chih Lung Chen
    Division of Biomaterial and Tissue Engineering, Industrial Technology Research Institute, Hsing Chu, Taiwan, Republic of China
    J Allergy Clin Immunol 118:105-12. 2006
    ..Serine proteases such as mast cell tryptase and certain allergens are important in the pathogenesis of allergic inflammation of asthma...
  99. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ..Although both cytokines use eotaxin to regulate eosinophilia, IL-13 is thought to operate a separate pathway to IL-5 to induce airways hyperreactivity (AHR) in the allergic ..
  100. ncbi Il-13 and IFN-gamma: interactions in lung inflammation
    J G Ford
    Department of Medicine, Harlem Hospital Center, Harlem Lung Center, Columbia University, New York, NY 10037, USA
    J Immunol 167:1769-77. 2001
    ..IFN-gamma inhibited IL-13-induced goblet cell hyperplasia and airway eosinophilia. At the same time, IFN-gamma and IL-13 potentiated each other's effects...
  101. ncbi Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
    Jonathan E Markowitz
    Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:777-82. 2003
    ..Corticosteroids, cromolyn, and elemental diet have all been reported as successful treatments for EoE. In this study, we sought to accurately define a population of patients with EoE and then assess their response to elemental diet...

Research Grants62

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..In this study the inflammation associated with asthma will be studied using both "traditional" markers such as eosinophilia, exhaled NO (eNO) and sinus CT score;as well as measurements of cytokines in serum and leukotrienes in urine...
  2. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..Interestingly, our recent preliminary studies suggest that Muc1-null mice fail to exhibit pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
  3. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ..anti-IL5 to 10 CSS patients for 4 months, yielding significant reduction of systemic steroid dose, peripheral eosinophilia, and CSS exacerbations...
  4. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ..defined and undefined myeloid disorders, and there remains an unmet need for treatment of unexplained eosinophilia and "chronic eosinophilic leukemia, not otherwise specified"...
  5. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ..defined and undefined myeloid disorders, and there remains an unmet need for treatment of unexplained eosinophilia and "chronic eosinophilic leukemia, not otherwise specified"...
  6. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..For example, while causing the mentioned changes resembling of human SLD, mIL-442 does not induce pulmonary eosinophilia or goblet cell hyperplasia (the features that are common in asthma but not in SLD, and that are readily induced ..
  7. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..Atopic asthma is characterized by an overproduction of Th2 cytokines (IL-4, IL-5 and IL-13), peripheral blood eosinophilia and elevated IgE level to a specific allergen...
  8. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..ribose)polymerase-1 (PARP-1) has been established as a mediator of inflammation and a player in asthmic eosinophilia. We study PARP-1 inhibition using PARP-1 knockout mice or a novel PARP-1 inhibitor, TiQ...
  9. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2012
    ..that intranasal administration of ClC3 siRNA prevented airway hyperresponsiveness to methacholine, BALF eosinophilia and airway inflammation in the lungs of allergic asthmatic mice...
  10. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ..suffer from enhanced disease severity and even death upon subsequent RSV infection concomitant with pulmonary eosinophilia. Severe lung inflammatory responses characterized by a skewed CD4+ T-cell response (in the absence of ..
  11. PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMA
    Hamid Boulares; Fiscal Year: 2013
    ..Asthma is, in part, a Th2 lymphocyte-mediated inflammatory airway disease characterized by pulmonary eosinophilia and airway hyper-responsiveness (AHR)...
  12. MOLECULAR PATHOLOGY OF CHRONIC LUNG DISEASE
    Craig Gerard; Fiscal Year: 2013
    ..We will additionally identify candidate genes responsible for eosinophilia in allergic airway responses...
  13. Trefoil Factors Regulate Th2 Immunity
    DEBROSKI R HERBERT; Fiscal Year: 2013
    ..is characterized by production of interleukins (IL's) 4, 5, 13, 25, and IL-33, immunoglobulin E (IgE) eosinophilia, mastocytosis, basophilia, alternatively activated macrophages (AAM), smooth muscle hypercontractility, and ..
  14. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..This could provide improved protective mucosal immunity and limit the damaging effects of tissue eosinophilia. A central hypothesis and topic of investigation of this proposal is that SIgA neutralizes allergen at the site ..
  15. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..AHR) in mice through direct effects on airway smooth muscle cells;2) AHR is induced independently of eosinophilia and goblet cell hyperplasia;3) induction of AHR by IL-4 and IL-13 requires signaling through the type 2 IL-4R;4)..
  16. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..vomiting, abdominal pain, dysphagia, food impaction and diarrhea that occur in conjunction with intestinal eosinophilia. Despite an increasing incidence estimated at 4 in 10,000, diagnostic criteria for one type of EGID, ..
  17. Anti IL5 and Churg Strauss Syndrome: a double blind, placebo controlled trial
    Michael E Wechsler; Fiscal Year: 2013
    ..of anti-IL5 (mepolizumab) in 10 CSS patients;anti-IL5 given for 4 months reduced CSS exacerbations, peripheral eosinophilia, and systemic corticosteroid dose...
  18. Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitis
    Seema S Aceves; Fiscal Year: 2013
    ..EE) is a chronic allergic disease of increasing prevalence diagnosed as an acid- independent esophageal eosinophilia of >15 per high power field...
  19. Role of Spi-C in eosinophil development and functional responses
    PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilia occurs in a variety of clinical disorders including parasitic infections, hypereosinophilic syndrome, cancer, and atopic diseases...
  20. An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to a
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..results using the RV challenge model suggest that inflammation, as judged by exhaled nitric oxide (FeNO) or eosinophilia, is as much a risk factor for a pulmonary response to the virus as it is a response that occurs during the ..
  21. Understanding Severe Asthma Using an Experimental Model
    Prabir Ray; Fiscal Year: 2013
    ..mice did not subdue the IFN-?/IL-17/IL-13 response or the airway neutrophilia but partially attenuated the eosinophilia. Airway hyperreactivity in these mice was also only partially attenuated by CS...
  22. Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils i
    Larry C Borish; Fiscal Year: 2013
    ..Specific Aim 2 will address the importance of IL-4 and IFN-3 in AERD. Although characterized by profound eosinophilia, cytokines typically associated with eosinophilia (e.g...
  23. Defining mechanisms for how Ndfip1 regulates T cell-mediated allergic responses
    ALLISON MARIE BEAL; Fiscal Year: 2012
    ..The inflammation is characterized by the presence of elevated serum IgE, eosinophilia, and T cells that produce high levels of T helper type 2 (Th2) type cytokines...
  24. The Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis Fibrogenesis
    Edaire Cheng; Fiscal Year: 2013
    ..The chronic esophageal eosinophilia of EoE is associated with tissue remodeling characterized by a unique pattern of subepithelial fibrosis leading ..
  25. Eosinophils support nematode infection
    Judith A Appleton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Eosinophilia is a hallmark of immune responses mounted against helminth infections...
  26. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2013
    ..g. the eotaxins), and in conjunction with IL-5, these chemokines induce lung eosinophilia, which in turn amplifies IL-13 production and IL-13-associated lung pathology including eosinophil-mediated ..
  27. REGULATION OF GASTROINTESTINAL EOSINOPHILS
    Marc E Rothenberg; Fiscal Year: 2013
    ..We identified a key role for IL-5 in eliciting esophageal eosinophilia and this provided the impetus for the current clinical trials now testing the role of humanized anti-IL-5 for ..
  28. CD103+ Dendritic Cells and Regulatory T cells in Food Allergy
    Sun Sang Sung; Fiscal Year: 2009
    ..An animal model for inducing intestinal allergic reactions to ovalbumin with eosinophilia, serum IgE levels, T helper 2 responses, intestinal inflammation, and diarrhea as indicators of allergy ..
  29. Naturally occurring T regulatory cells control airway hyperresponsiveness
    ERWIN WILLIAM GELFAND; Fiscal Year: 2013
    ..to challenge suppress all aspects of lung allergic responses including airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and goblet cell metaplasia...
  30. Is Sputum Eosinophilia A Prognosis Factor for Occupational Asthma? A proof of Con
    Catherine Lemiere; Fiscal Year: 2011
    ..To compare the clinical, functional and inflammatory characteristics of workers with (Eos+) and without sputum eosinophilia (Eos-) after specific inhalation challenges (SIC) at the time of the diagnosis;2...
  31. The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.
    TANYA MARIA LAIDLAW; Fiscal Year: 2013
    ..Although the cause is unknown, the syndrome is consistently associated with tissue eosinophilia and elevated generation of cysteinyl leukotrienes, the latter of which may reflect a disturbance in the ..
  32. The Role of Ikaros in Regulatory T Cells that Protect Against Allergic Asthma
    SARAH UMETSU; Fiscal Year: 2011
    ..Th2 biased immune responses to environmental antigens are thought to cause pulmonary inflammation, airway eosinophilia, mucus hypersecretion and airway hyperreactivity (AHR), cardinal features of asthma...
  33. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
    ..The innovation for this proposal is connecting neuropeptide signaling to explain eosinophilia in an in vivo fugal allergic asthma model to improve training of NDSU students in molecular (Dr...
  34. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2013
    ..doses of an extract (Df) from the HDM to C57BL/6 or BALB/c mice causes robust peribronchial and perivascular eosinophilia, goblet cell metaplasia, and a mixed T helper (Th)2, Th1, and Th17-type immune response in the lungs...
  35. Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
    Glenn T Furuta; Fiscal Year: 2013
    ..nausea, vomiting, abdominal pain, dysphagia and food impaction that occur in conjunction with esophageal eosinophilia. To date, the only method to make EoE diagnoses and follow treatment responses in EoE is invasive endoscopy ..
  36. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
    ..have demonstrated that all of the pathologies in I5/hE2 mice are absolutely dependent on the induced pulmonary eosinophilia. This proposal capitalizes on the availability of the I5/hE2 transgenic model as well as our unique eosinophil-..
  37. Transnasal Probe for Diagnosing Eosinophilic Esophagitis
    Guillermo J Tearney; Fiscal Year: 2013
    ..Beyond its immediate clinical impact, this technology can also be used in future investigational studies to expand our knowledge of EoE and other diseases such as asthma that are characterized by tissue eosinophilia.
  38. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2012
    ..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
  39. miR-21 in the Pathogenesis of Asthma
    THOMAS XUEFENG LU; Fiscal Year: 2012
    ..The severity of asthma is often correlated with the level of airway eosinophilia. Correspondingly, miR-21 has been found to be up- regulated stepwise during eosinophil development...
  40. The Pathogenesis of Chronic Rhinosinusitis
    Hirohito Kita; Fiscal Year: 2012
    ..Persistent inflammation, eosinophilia and increased numbers of T cells producing Th2-type cytokines are commonly seen in the sinus mucosa of CRS ..
  41. A multi-center clinical trial of 1760 mcg of daily swallowed fluticasone vs. plac
    Marc E Rothenberg; Fiscal Year: 2010
    ..EE is differentiated from GERD by the magnitude of mucosal eosinophilia and epithelial thickening, its association with atopy, its much lower incidence (~1:10,000) and the lack of ..
  42. Eicosanoid Networks in Aspirin Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2013
    ..genetic deletion or pharmacologic blockade of TP receptors completely protect ptges-/- mice from bronchial eosinophilia, Th2 cytokine generation, and pulmonary ICAM-1 induction despite persistent high level pulmonary cys-LT ..
  43. Mechanisms of Eosinophilic Inflammation in Human Disease
    Hirohito Kita; Fiscal Year: 2012
    ..Airway inflammation in patients with asthma is characterized by airway eosinophilia and increased numbers of lymphocytes producing Th2-type cytokines...
  44. Airway Inflammation-Related Inhibition of Disease (AIRID)
    LAUREN E COHN; Fiscal Year: 2012
    ..In Th2 models, AHR, mucus and eosinophilia are reduced. We call this pathway Airway Inflammation-Related Inhibition of Disease (AIRID)...
  45. Regulation of Pulmonary Inflammation by Leukotriene E4
    Joshua A Boyce; Fiscal Year: 2013
    ..is a weak agonist of the classical cysteinyl leukotriene receptors (CysLTRs), but a potent inducer of bronchial eosinophilia and airway hyperresponsiveness in humans...
  46. Role of CC Chemokine Ligand 23 in Chronic Rhinosinusitis
    Atsushi Kato; Fiscal Year: 2013
    ..We also have found that high levels of CCL23 are significantly correlated with eosinophilia and macrophage accumulation in nasal polyps...
  47. Role of Eosinophils in Airway Inflammation and Remodeling
    Nizar N Jarjour; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Airway eosinophilia is an important marker of asthma severity, risk of exacerbation, and response to therapy...
  48. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2013
    ..immunoglogulin E (IgE) concentrations, airway hyperresponsiveness, excessive airway mucus production, lung eosinophilia, and airway remodeling...
  49. ITK Mast Cells and Allergic Airway Responses
    Avery August; Fiscal Year: 2011
    ..S. Patients with allergic asthma have symptoms of airway inflammation, with eosinophilia, increased mucous production in the lung and serum IgE, along with airway hyper responsiveness...
  50. Immune Regulation in the Respiratory Tract by the Epithelial Protein PLUNC
    LAUREN E COHN; Fiscal Year: 2010
    ..In studies where PLUNC is inhibited by intranasal siRNA, increased eosinophilia was observed in naive mice and mice with Th2 inflammation...
  51. STRUCTURE AND FUNCTION OF THE LYMPHOCYTE FCE RECEPTOR
    Daniel H Conrad; Fiscal Year: 2012
    ..will utilize both IgE and the new ADAM10 transgenics in order to evaluate the mechanism of the suppression of eosinophilia as well as the capacity of CD23 to modulate the asthma phenotype...
  52. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..sensitive and specific method for measuring esophageal inflammation in EE patients, particularly tissue eosinophilia, cytokine and chemokine profiles, and levels of CD23, FceRI and tryptase, and (2) use the EST to monitor ..
  53. Role of basophils and IgE in the immune response to Litomosoides
    EDWARD E MITRE; Fiscal Year: 2010
    ..They cause a type 2 immune response characterized by eosinophilia, elevated serum levels of Ag-specific and polyclonal lgE, and increases in T-cell production of IL-4, IL-5, and ..
  54. Mechanistic Analysis of Eosinophilic Esophagitis.
    Anil Mishra; Fiscal Year: 2013
    ..basic information concerning the cell type, the molecules and cells involved in the regulation of esophageal eosinophilia, and the potential significance of these findings to understand the pathogenesis of human EE...
  55. ST6Gal-1 Sialyltransferase in Allergic Airway Inflammation
    Joseph T Y Lau; Fiscal Year: 2010
    ..Expression of recombinant ST6Gal-1 in vivo can attenuate the pulmonary eosinophilia, suggesting a therapeutic potential for ST6Gal-1...
  56. Notch signaling-mediated functions of airway eosinophils in lung disease
    LISA ANN SPENCER; Fiscal Year: 2013
    ..eosinophil functions pertinent to asthma, and by extension other inflammatory diseases of the lung involving eosinophilia, relevant to development of novel, targeted therapeutic approaches...
  57. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
    ..of eosinophil protein), but also its secretion by activated eosinophils, elevated blood levels in patients with eosinophilia, and increased levels in sputum and BAL of asthmatics, all argue for an important role in eosinophil function...
  58. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999
    ..The resulting mice appear to have a characteristic phenotype which includes a mild peripheral blood eosinophilia and a significant increase in resident cutaneous eosinophil infiltrates...
  59. CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENES
    Steven Ackerman; Fiscal Year: 2006
    ..IL-5 is selective for the eosinophil lineage, playing a key role in regulating blood and tissue eosinophilia in infectious and allergic processes...
  60. BRUGIAN FILARIASIS IN THE FERRET
    CATHERINE CRANDALL; Fiscal Year: 1990
    ..The proposed study will investigate the immunopathology of two manifestations of infection: tropical filarial eosinophilia (occult filariasis) and chronic lymphedema...
  61. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
    ..such as eosinophils, and that in asthma this function is impaired contributing to persistent pulmonary eosinophilia. These studies will address molecular mechanisms which regulate the functional expression of FasL on airway ..
  62. VIRAL EXACERBATIONS OF ASTHMA
    Scherer Sanders; Fiscal Year: 2002
    ..colony stimulating factor (GM-CSF) from infected epithelial cells plays a central role in enhancing bronchial eosinophilia, and that this increase in activated eosinophils in the airway triggers disease exacerbations in asthmatics...