Genomes and Genes
Summary: Abnormal increase in eosinophils in the blood, tissues or organs.
Publications278 found, 100 shown here
- Eosinophils express functional IL-13 in eosinophilic inflammatory diseasesPeter Schmid-Grendelmeier
Swiss Institute for Allergy and Asthma Research, Davos Platz, Switzerland
J Immunol 169:1021-7. 2002..In conclusion, human eosinophils are able to produce and release functional IL-13 in eosinophilic inflammatory responses...
- Eosinophilic esophagitisRichard J Noel
N Engl J Med 351:940-1. 2004
- Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsiaM M Walker
Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College, London, UK
Aliment Pharmacol Ther 29:765-73. 2009..Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function...
- IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoidsCarine Blanchard
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 120:1292-300. 2007..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal ..
- Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophiliaE A Garcia-Zepeda
Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Nat Med 2:449-56. 1996..To determine whether a similar molecule might play a role in human inflammatory diseases characterized by eosinophilia, we isolated the human eotaxin gene...
- Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch testsJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
Ann Allergy Asthma Immunol 95:336-43. 2005..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
- Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infectionElizabeth S Magalhães
Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
FASEB J 23:1262-71. 2009..of inflammatory diseases, including asthma, in which it enhances airway hypersensitivity and tissue eosinophilia. Herein, we investigated the role of MIF in eosinophilopoiesis and tissue eosinophilia using Schistosoma ..
- Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbuminXiaobing Han
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Eur J Immunol 34:981-9. 2004..Moreover, adoptive transfer of iIDC, but not iNDC, could inhibit systemic and local eosinophilia induced by allergen exposure...
- Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T6741 mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapyHiroaki Ohnishi
Br J Haematol 134:547-9. 2006
- Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatmentAyalew Tefferi
Department of Internal Medicine and Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 80:75-83. 2005Acquired blood eosinophilia is considered either a primary or a secondary phenomenon...
- Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitisAmir F Kagalwalla
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1097-102. 2006..However, compliance with an exclusive, poor-tasting liquid formulation is difficult...
- Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?Fouad El Sayed
Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon
Head Face Med 2:32. 2006Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region...
- Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosisShweta Saxena
Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, India
J Allergy Clin Immunol 111:1001-7. 2003..Studies from our group have shown a protective role of pulmonary surfactant protein A (SP-A) against lung allergy and infections caused by Aspergillus fumigatus...
- Immune expulsion of the trichostrongylid Cooperia oncophora is associated with increased eosinophilia and mucosal IgAK Kanobana
Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80 165, 3508, Utrecht, TD, The Netherlands
Int J Parasitol 32:1389-98. 2002..Our results describe the involvement of both eosinophils and mucosal IgA in the regulation of C. oncophora expulsion and suggest the development of a Th2 effector immune response...
- Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophiliaD Robert Webb
Allergy and Asthma Research Associates, Kirkland, Washington 98034, USA
Ann Allergy Asthma Immunol 88:385-90. 2002..Objective: To evaluate the efficacy of intranasal fluticasone propionate (FP) in the treatment of patients with perennial nonallergic rhinitis, with and without nasal eosinophilia.
- The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophiliaMatthew R Olson
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 181:7958-68. 2008..respiratory syncytial virus (FI-RSV) vaccine experienced enhanced respiratory disease, including pulmonary eosinophilia, after contracting a natural RSV infection...
- Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 yearsAlex Straumann
Department of Gastroenterology, Kantonsspital, Olten, Switzerland
Gastroenterology 125:1660-9. 2003..Before this study, the natural course of eosinophilic esophagitis had not been defined and information regarding potential long-term risks was lacking...
- Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritisD A Schwartz
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Dig Dis Sci 46:1787-90. 2001..To our knowledge, this is the first use of montelukast as a steroid sparing agent for eosinophilic gastroenteritis...
- Eosinophil-associated gastrointestinal disorders: a world-wide-web based registryJesus R Guajardo
Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Pediatr 141:576-81. 2002....
- A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lipHiromi Suzuki
Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
J Dermatol 32:991-5. 2005Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare...
- Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitisSoon Bahrami
Department of Pathology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Arch Dermatol 142:155-61. 2006OBJECTIVE: To determine whether tissue eosinophilia is a reliable indicator of a drug-induced etiology in biopsy samples demonstrating leukocytoclastic vasculitis...
- Eosinophilic meningitisVincent Lo Re
Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Med 114:217-23. 2003..It is defined by the presence of 10 or more eosinophils/microL in the cerebrospinal fluid (CSF) or a CSF eosinophilia of at least 10%...
- Nonallergic rhinitis with eosinophilia syndromeAnne K Ellis
Curr Allergy Asthma Rep 6:215-20. 2006Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis ..
- Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challengeNathalie Etchart
Lung Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
Eur J Immunol 36:1136-44. 2006..These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection...
- Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in miceM D Inman
Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
Am J Respir Cell Mol Biol 21:473-9. 1999..05). We observed that allergen-induced airway eosinophilia is accompanied by increases in BM eosinophil progenitors, indicating that in this model, increased eosinophil ..
- Bullous "cellulitis" with eosinophilia: case report and review of Wells' syndrome in childhoodAmy E Gilliam
Department of Dermatology, University of California, 1701 Divisadero St, 3rd Floor, San Francisco, CA 94115, USA
Pediatrics 116:e149-55. 2005..onset of edematous erythematous plaques associated with bullae on her extremities and accompanied by peripheral eosinophilia. She was afebrile, and the skin lesions were pruritic but not tender...
- Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostainingP Kiehl
Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
Br J Dermatol 145:720-9. 2001The frequency and amount of tissue eosinophilia in spontaneous lesions of acute and chronic atopic dermatitis (AD) are still a matter of controversy, and little is known about the distribution of eosinophilia in skin.
- Focal eosinophilic infiltration in the liver: radiologic findings and clinical courseS Y Yoo
Department of Radiology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
Abdom Imaging 28:326-32. 2003..and signs included abdominal pain (n = 4), easy fatigability (n = 3), weight loss (n = 1), and peripheral eosinophilia (n = 19). Twelve patients were asymptomatic...
- Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in miceMahmoud A Pouladi
McMaster University, Department of Pathology and Molecular Medicine, Health Sciences Centre, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
Am J Respir Cell Mol Biol 30:84-90. 2004..The ensuing inflammatory response is characterized by a Th2 cytokine profile, OVA-specific IgE, and airway eosinophilia. Using real-time, quantitative reverse transcriptase-polymerase chain reaction we assessed MMP-12 mRNA ..
- Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitisS Arakawa
Department of Anatomy, Biology and Medicine Dermatology, Faculty of Medicine, Oita University, Oita, Japan
Clin Exp Immunol 135:505-10. 2004..These results suggest GATA-3 and Txk might be involved in skin lesions, while SOCS-3 might be associated with an imbalance of cytokines that is difficult to normalize in atopic dermatitis...
- Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in childrenDavid A Jacobsohn
Department of Pediatrics, Children s Memorial Hospital, Chicago, IL 60614, USA
Transplantation 77:1096-100. 2004..Because of recent data suggesting that cGVHD may be a Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD exists...
- Hepatic involvement of visceral larva migrans due to Toxocara canis: a case report--CT and MR findingsKoichiro Azuma
Department of Radiology, Kameda Medical Center, Kamogawa, Chiba, Japan
Radiat Med 20:89-92. 2002..A 44-year-old man presented with chills, eruptions, marked leukocytosis (31,400/microlitter), and eosinophilia (eosinophil, 72%). Multiple liver nodules were detected as low-density lesions on computed tomography (CT)...
- Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseasesSebnem Ustun
Department of Gastroenterology, School of Medicine, University of Ege, 35100 Bornova, Izmir, Turkey
World J Gastroenterol 10:3643-6. 2004Intestinal parasitic diseases are commonly accompanied with diarrhoeal symptoms and allergic reactions. Eosinophilia occurs as a result of IL-5 synthesized from Th2 cells during allergic reactions...
- Sputum eosinophilia in idiopathic pulmonary fibrosisS S Birring
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom
Inflamm Res 54:51-6. 2005..We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study...
- MR findings in eosinophilic infiltration of the liverJoo Sung Sun
Department of Diagnostic Radiology, Ajou University, College of Medicine, Kyunggido, Korea
J Comput Assist Tomogr 29:191-4. 2005..These findings should help to distinguish focal eosinophilic infiltration, especially from metastasis in patients with malignancy...
- Focal eosinophilic necrosis versus metastasis in the liver: the usefulness of two-phase dynamic CTJin Hur
Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine and YongDong Severance Hospital, 146-92, Dogok-dong, Kangnam-ku, Seoul 135-270, South Korea
AJR Am J Roentgenol 184:1085-90. 2005..Two-phase dynamic CT was found to be useful at differentiating focal eosinophilic necrosis from metastasis...
- Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypesGerald E Hancock
Department of Immunology Research, Wyeth Vaccines, West Henrietta, New York 14586 9728, USA
J Med Virol 70:301-8. 2003..As demonstrated by IL-5-dependent pulmonary eosinophilia after challenge and serum anti-G protein IgG1 to IgG2 ratios, highly purified native G protein sensitized all ..
- Substance P and the neurokinin-1 receptor in relation to eosinophilia in ulcerative colitisMaria Jonsson
Department of Integrative Medical Biology, Section of Anatomy, Umea University, SE 90187 Umea, Sweden
Peptides 26:799-814. 2005..Furthermore, for the majority of cases where there is marked derangement of the mucosa, it is apparent that there is an upregulation of the NK-1 receptor in the epithelium in parallel with the infiltration of the eosinophils...
- MRI findings of focal eosinophilic liver diseasesYoung-Kon Kim
Department of Diagnostic Radiology, Chonbuk National University Hospital, Chonju, Korea
AJR Am J Roentgenol 184:1541-8. 2005..In addition, eosinophilic abscess and focal eosinophilic infiltration showed different MRI findings from each other...
- Diagnostic significance of blood eosinophilia in returning travelersC Schulte
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany
Clin Infect Dis 34:407-11. 2002This study was conducted to investigate the predictive value of blood eosinophilia (total white blood cell count with > or =8% eosinophils) for the diagnosis of travel-related infections in 14,298 patients who returned from developing ..
- Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophiliaPeter Ngo
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Gastroenterol 101:1666-70. 2006..The aim of this case series is to demonstrate that features thought to be consistent with a diagnosis of allergic esophagitis are also observed in peptic esophagitis...
- Familial dysphagia and eosinophiliaDavid A Zink
Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
Gastrointest Endosc 65:330-4. 2007..Recent reports suggest a familial predisposition to eosinophilic esophagitis (EE) and a link between Schatzki's rings and EE...
- A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in miceMasato Komai
Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
J Pharmacol Sci 112:203-13. 2010..Therefore, a CCR3 antagonist may be useful in the treatment of airway remodeling, especially subepithelial and peribronchial fibrosis, in allergic asthma...
- Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment updateAyalew Tefferi
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 85:158-64. 2010Acquired eosinophilia is operationally categorized into secondary, clonal, and idiopathic types. Causes of secondary eosinophilia include parasite infections, allergic or vasculitis conditions, drugs, and lymphoma...
- Effect of omalizumab on peripheral blood eosinophilia in allergic asthmaM Massanari
Novartis Pharmaceuticals Corp, East Hanover, NJ 07936 1080, USA
Respir Med 104:188-96. 2010b>Eosinophilia is an established marker of asthma-related inflammation...
- Eosinophilic meningitis due to Angiostrongylus cantonensis in GermanyFelix Luessi
Department of Neurology, Johannes Gutenberg University Mainz, D 55101 Mainz, Germany
J Travel Med 16:292-4. 2009..The presence of a compatible epidemiologic history and eosinophilia in cerebrospinal fluid (CSF) lead to the diagnosis, which was confirmed by detection of specific antibodies...
- Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failureMajed Eshki
Department of Dermatology, Bichat Claude Bernard Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France
Arch Dermatol 145:67-72. 2009Factors implicated in the severity of drug reaction with eosinophilia and systemic symptoms (DRESS) have not been identified...
- The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drugYoko Kano
Department of Dermatology, Kyorin University School of Medicine, 6 20 2 Shinkawa Mitaka, Tokyo 181 8611, Japan
Immunol Allergy Clin North Am 29:481-501. 2009Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, ..
- Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosisAli Emad
Department of Internal Medicine, Section of Pulmonary Diseases, Shiraz University of Medical Sciences, Shiraz, Iran
J Clin Immunol 27:605-12. 2007....
- The utility of screening for parasitic infections in HIV-1-infected Africans with eosinophilia in LondonLiat Sarner
The Greenway Centre, Newham General Hospital, Glen Road, London E13 8SL, UK
Int J STD AIDS 18:626-9. 2007The presence of asymptomatic eosinophilia in HIV patients has been demonstrated to have a wide variety of causes. Untreated parasitic infections in immunocompromised individuals can have potentially serious consequences...
- Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitisB Sastre
Immunology Department Fundación Jiménez Díaz Capio, CIBERES ISCIII, Madrid, Spain
Allergy 63:58-66. 2008Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness...
- Metastasis versus focal eosinophilic infiltration of the liver in patients with extrahepatic abdominal cancer: an evaluation with gadobenate dimeglumine-enhanced magnetic resonance imagingMi Suk Park
Department of Diagnostic Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University of Medicine, Seoul, Korea
J Comput Assist Tomogr 33:119-24. 2009..To determine the performance of gadobenate dimeglumine (Gd-BOPTA)-enhanced magnetic resonance imaging (MRI) to differentiate focal eosinophilic infiltration (FEI) from metastasis...
- Relationships between eosinophilia, anti-Fasciola IgG, and IgM rheumatoid factors, in urban and rural areas of north-western SpainA Sanchez-Andrade
Rheumatology Department, Hospital Xeral Calde, Dr Ochoa, S N, 27004 Lugo, Spain
Ann Trop Med Parasitol 102:489-98. 2008..patients attending a hospital in Lugo, in north-western Spain, to investigate possible relationships between eosinophilia, IgG antibodies against the parasitic helminth Fasciola hepatica, and IgM rheumatoid factors (IgM-RF)...
- Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine strain of Francisella tularensisR KuoLee
Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
Clin Exp Allergy 38:1003-15. 2008....
- Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4Hiromi Okigami
Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Disease Research, Japan
Eur J Pharmacol 559:202-9. 2007..These data support the use of small molecule VLA-4 antagonists in the treatment of relevant diseases, such as asthma, atopic dermatitis, or allergic rhinitis...
- Nonallergic rhinitis with eosinophilia syndrome and related disordersAnne K Ellis
Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
Clin Allergy Immunol 19:87-100. 2007..Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or LT receptor antagonists as an adjuvant...
- TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infectionMingjian Fei
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 108:5360-5. 2011..Our study identifies TNF-α as a molecular switch that orchestrates a sequence of events in DCs and CD4 T cells that promote neutrophilic airway inflammation...
- Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinkingS A Walsh
Department of Dermatology, King s College Hospital, Denmark Hill, London, UK
Clin Exp Dermatol 36:6-11. 2011Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a severe medication-induced adverse reaction, which has cutaneous, haematological and solid-organ features...
- Isomaltitol exacerbates neutrophilia but reduces eosinophilia: new insights into the sephadex model of lung inflammationChamilly Evaldsson
Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, Linkoping, Sweden
Int Arch Allergy Immunol 154:286-94. 2011..The Sephadex-induced lung inflammation model was considered a suitablemodel due to the significant changes in global inflammatory endpoints seen upon provocation with Sephadex...
- Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazineJeremy Rosenbaum
Department of Gastroenterology, The Royal Children s Hospital, Melbourne, Victoria, Australia
J Paediatr Child Health 46:193-6. 2010..infectious causes are the most important to exclude in a timely manner and drug rash and eosinophilia with systemic symptoms (DRESS) is another differential diagnosis that should be considered in children...
- Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocyclineAmy E Vinson
Department of Pediatrics, Rhode Island Hospital, Hasbro Children s Hospital, Providence, RI, USA
Pediatr Crit Care Med 11:e38-43. 2010Drug rash, eosinophilia, and systemic symptoms syndrome is a type of drug hypersensitivity reaction characterized by the clinical triad of skin eruption, fever, and internal organ involvement...
- Implications of eosinophilia in the normal duodenal biopsy - an association with allergy and functional dyspepsiaM M Walker
Department of Histopathology, Imperial College London, UK
Aliment Pharmacol Ther 31:1229-36. 2010Allergy and functional gastrointestinal disorders have been associated with eosinophilia in duodenal mucosa.
- Travel-related schistosomiasis, strongyloidiasis, filariasis, and toxocariasis: the risk of infection and the diagnostic relevance of blood eosinophiliaGijs G Baaten
Department of Infectious Diseases, Public Health Service GGD Amsterdam, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, The Netherlands
BMC Infect Dis 11:84. 2011..study prospectively assessed the occurrence of clinical and subclinical schistosomiasis, strongyloidiasis, filariasis, and toxocariasis, and the screening value of eosinophilia in adult short-term travelers to helminth-endemic countries.
- Differential modulation of allergic eye disease by chronic and acute ascaris infectionLisa Schopf
Agricultural Research Service, Beltsville Human Nutrition Research Center, Nutrient Requirements and Functions Laboratory, U.S. Department of Agriculture, Beltsville, MD, USA
Invest Ophthalmol Vis Sci 46:2772-80. 2005....
- Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndromeHans Uwe Simon
Department of Pharmacology, University of Bern, Bern, Switzerland
Eur J Immunol 33:834-9. 2003..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites...
- Second-hand smoke increases bronchial hyperreactivity and eosinophilia in a murine model of allergic aspergillosisBrian W P Seymour
Department of Pathology, Microbiology and Immunology, 1126 Haring Hall, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Clin Dev Immunol 10:35-42. 2003..of airway hyperresponsiveness being mediated by an enhanced type 1 hypersensitivity response include: eosinophilia in peripheral blood and lung sections...
- Th2 immune responses in GATA-3-transgenic mice infected with Heligmosomoides polygyrusNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 131:11-4. 2003..These results suggest that GATA-3 promotes IL-5 and IL-13 production, and that the function of these cytokines results in eosinophilia and hyper-IgE, respectively.
- Modulation of airway inflammation by immunostimulatory CpG oligodeoxynucleotides in a murine model of allergic aspergillosisBanani Banerjee
Allergy Immunology Division, Department of Pediatrics, Medical College of Wisconsin, Research Service, VA Medical Center, Milwaukee, Wisconsin 53295, USA
Infect Immun 72:6087-94. 2004..fumigatus-sensitized mice. The distinct reduction in peripheral blood eosinophilia and airway remodeling in CpG-ODN-treated mice emphasized its usefulness as an immunomodulating agent for ..
- Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma modelMariette Lisbonne
Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2444, Paris V, Hopital Necker, Paris, France
J Immunol 171:1637-41. 2003..deficient in the invariant Valpha14(+) (iValpha14), CD1d-restricted NKT cells, exhibit impaired AHR and airway eosinophilia, decreased IL-4 and IL-5 production in bronchoalveolar lavage fluid, and reduced OVA-specific IgE compared with ..
- Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgEGergely T Kozma
Department of Genetics, Cell and Immunobiology, Semmelweis University Medical School, Budapest 1445, Hungary
Int Immunol 15:963-73. 2003..HDC-KO mice had significantly reduced airway hyper-responsiveness, lung inflammation, bronchoalveolar lavage eosinophilia, and OVA-specific IgE compared with congenic wild-type littermates treated in the same way...
- Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humansLisa M Ganley-Leal
Centers for Disease Control and Prevention, Division of Parasitic Diseases, 4770 Buford Hwy, N.E, Atlanta, GA 30341, USA
Infect Immun 74:2169-76. 2006..Previous studies have demonstrated an association of peripheral eosinophilia with resistance to reinfection with schistosomes...
- Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5Brigita Sitkauskiene
The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, , Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
Am J Respir Cell Mol Biol 30:367-78. 2004..However, bronchoalveolar lavage (BAL) eosinophilia was not attenuated to the same degree...
- Eosinophils in asthma and airway hyperresponsivenessChristopher E Brightling
Am J Respir Crit Care Med 169:131-2; author reply 132-3. 2004
- Magnitude of late asthmatic response to allergen in relation to baseline and allergen-induced sputum eosinophilia in mild asthmatic patientsFederico L Dente
Cardio Thoracic Department, Respiratory Pathophysiology, University Hospital of Pisa, Pisa, Italy
Ann Allergy Asthma Immunol 100:457-62. 2008..Late asthmatic response (LAR) to allergen challenge is a validated method for studying the pathogenesis of and new treatments for asthma in the laboratory...
- [Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management]U von Arnim
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Otto von Guericke Universitat Magdeburg, Deutschland
Z Gastroenterol 45:1257-63. 2007..Currently it is still not known whether the late complications of EE can be prevented by the use of anti-inflammatory agents and this can only be demonstrated through further long-term follow-up studies...
- DA-9201 shows anti-asthmatic effects by suppressing NF-kappaB expression in an ovalbumin-induced mouse model of asthmaSeung-Ho Lee
Research Institutes of Dong-A Pharmaceutical Company, Yongin, Korea
Arch Pharm Res 28:1350-7. 2005..These results suggest that DA-9201 may be useful for the treatment of asthma and its efficacy is related to suppression of NF-kappaB pathway...
- Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine modelEsther Lopez
Immunology Department, Fundacion Jimenez Diaz Capio, Madrid, Spain
J Immunol 176:1943-50. 2006..Plasmid-encoding Gal-3 acts as a novel treatment for chronic asthma in mice producing nearly complete blockade of Ag responses with respect to eosinophil airway accumulation, airway hyperresponsiveness, and remodeling...
- Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthmaW Feleszko
Department of Pediatric Pneumology and Allergy, The Medical University Children s Hospital, Warszawa, Poland
Clin Exp Allergy 37:498-505. 2007..Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far...
- Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitisS Muller
Institute of Pathology, Munich University, Munich, Germany
Endoscopy 39:339-44. 2007..In this study, symptoms, accompanying allergic disorders, and endoscopic findings in 117 patients with eosinophilic esophagitis were analyzed retrospectively...
- Role of local pulmonary IFN-gamma expression in murine allergic airway inflammationMarkus Koch
Department of Immunology, Max Planck Institute for Infection Biology, Campus Charite Mitte, Schumannstrasse 21 22, 10117 Berlin, Germany
Am J Respir Cell Mol Biol 35:211-9. 2006..Consistent with this observation, eosinophilia in bronchoalveolar lavage of CC10-IFN-gamma-tg-IFN-gamma-KO mice was profoundly increased, indicating that this ..
- Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in miceMyung Goo Min
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
J Immunol 178:5321-8. 2007....
- Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergensEric B Brandt
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 118:420-7. 2006..was sustained for up to 12 days after the last intragastric OVA challenge after resolution of blood eosinophilia. When mice with gastrointestinal allergy were repeatedly challenged with HDM in the respiratory tract, they ..
- Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized miceV J Erpenbeck
Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
Clin Exp Allergy 36:930-40. 2006The surfactant protein SP-D has been reported to reduce bronchial hyper-responsiveness, blood eosinophilia, and T-helper type 2 cytokines in models of allergic asthma...
- CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthmaHua hao Shen
Department of Respiratory Diseases, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China
Acta Pharmacol Sin 27:1594-9. 2006To explore the effect of a rat anti-mouse CC-chemokine receptor-3 (CCR3) monoclonal antibody (CCR3 mAb) on airway eosinophilia and mucus overproduction in asthmatic mice.
- Clinical presentation of patients with eosinophilic inflammation of the esophagusSachin Baxi
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Gastrointest Endosc 64:473-8. 2006..MAIN OUTCOME MEASUREMENTS: Clinical characterization of patients with esophageal eosinophilia. RESULTS: There was no significant difference in patient demographics...
- Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitisSandeep K Gupta
Indiana University, Indianapolis, Indiana, USA
J Pediatr Gastroenterol Nutr 42:22-6. 2006..We studied the expression of cytokines and inflammatory cells in normal and inflamed esophageal mucosa of children with the aim of furthering our understanding of the pathophysiology of allergic eosinophilic esophagitis (AEE)...
- B and T lymphocyte attenuator inhibits antigen-induced eosinophil recruitment into the airwaysTomohiro Tamachi
Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
Int Arch Allergy Immunol 143:50-5. 2007..However, the role of B and T lymphocyte attenuator (BTLA), an inhibitory co-receptor expressed preferentially in Th1 cells, in the regulation of allergic airway inflammation remains to be determined...
- Noninvasive markers of eosinophilic esophagitisSandeep K Gupta
Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, ROC 4210, Indianapolis, IN 46202, USA
Gastrointest Endosc Clin N Am 18:157-67; xi. 2008..The complex pathophysiology of EE and eosinophil physiology provide several candidate biomarkers that could be studied on various noninvasively obtained body specimens. This article reviews several potential noninvasive biomarkers of EE...
- Otorhinolaryngologic manifestations of eosinophilic esophagitisDana M Thompson
Division of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastrointest Endosc Clin N Am 18:91-8; ix. 2008..Team collaboration between otolaryngologists, allergists, and gastroenterologists will assure the best treatment in this select group of predisposed patients...
- Effects of L-arginine and phosphodiesterase-5 inhibitor, sildenafil, on inflammation and airway responsiveness of sensitized BP2 miceB Al Qadi Nassar
UMR Qualisud Laboratoire de Pharmacologie, Faculte de Pharmacie, Montpellier, France
Fundam Clin Pharmacol 21:611-20. 2007....
- Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patientsKenichiro Kojima
Department of Internal Medicine, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
Nephrol Dial Transplant 20:1932-5. 2005b>Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients.
- CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthmaJohn R Gordon
Immunology Research Group, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
J Immunol 175:1516-22. 2005....
- Characteristic features of allergic airway inflammation in a murine model of infantile asthmaYasushi Ohki
Department of Pediatrics and Developmental Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
Int Arch Allergy Immunol 138:51-8. 2005..BHR, airway eosinophilia, the inflammatory cell infiltration, goblet cell metaplasia (GCM), and IgE antibody production were more ..
- Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354)C Blanchard
Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Clin Exp Allergy 35:1096-103. 2005..of IL-13, a cytokine associated with the induction of airway hyper-responsiveness (AHR), chronic pulmonary eosinophilia, airway mucus overproduction and eosinophilic oesophagitis...
- Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthmaAmy L Greene
Department of Biochemistry and Molecular Biology, Medical School Duluth, University of Minnesota, 55812, USA
Toxicol Sci 88:420-33. 2005..TMA), a small molecular weight chemical, and ovalbumin (OVA), a reference protein allergen, cause asthma with eosinophilia. To test the hypothesis that different allergens elicit symptoms of asthma via different effector pathways, ..
- Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in miceHiroko Saito Akei
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 129:985-94. 2005..The development of experimental EE is associated with significant skin eosinophilia, accelerated bone marrow eosinophilopoiesis, blood eosinophilia, and large increases in serum antigen-specific ..
- Effect of disodium cromoglycate on airway mucus secretion during antigen-induced late asthmatic responses in a murine model of asthmaHarumi Koyama
Department of Pediatrics and Developmental Medicine, Gunma University, Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan
Int Arch Allergy Immunol 138:189-96. 2005..We also studied the potency of DSCG in inhibiting mucus secretion and on airway eosinophilia. METHODS: Mice were subjected to initial intraperitoneal sensitization and airway challenge to ovalbumin (OVA) ..
- Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin BP W Hellings
Laboratory of Experimental Immunology, Department of Otorhinolaryngology, University Hospitals, Faculty of Medicine, University of Leuven, Belgium
Clin Exp Allergy 36:1063-71. 2006..We used a mouse model of airway allergy to study the effects of nasal or bronchial contact with SEB on bronchial allergic inflammation...
- Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot studyJohan C Kips
Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Am J Respir Crit Care Med 167:1655-9. 2003..We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials...
- Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory responseA Straumann
Department of Gastroenterology, Kantonsspital, Olten, Switzerland
J Allergy Clin Immunol 108:954-61. 2001..T cells, IL-5, eosinophils, and IgE-mediated mechanisms appear to be involved, giving rise to the possibility that allergic reactions might play a role in the pathogenesis of the disease...
- Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthmaP D Mehlhop
Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 94:1344-9. 1997..Both groups of animals developed bronchoalveolar lavage eosinophilia and pulmonary parenchymal eosinophilia...
- ASTHMA AND ALLERGIC DISEASE CENTERThomas Platts Mills; Fiscal Year: 2007..In this study the inflammation associated with asthma will be studied using both "traditional" markers such as eosinophilia, exhaled NO (eNO) and sinus CT score; as well as measurements of cytokines in serum and leukotrienes in urine...
- IL-13 Associated Eosinophil Lung ResponsesMarc E Rothenberg; Fiscal Year: 2010..g. the eotaxins), and in conjunction with IL-5, these chemokines induce lung eosinophilia, which in turn amplifies IL-13 production and IL-13-associated lung pathology including eosinophil-mediated ..
- IL-13 Associated Eosinophil Lung ResponsesMARC ROTHENBERG; Fiscal Year: 2009..g. the eotaxins), and in conjunction with IL-5, these chemokines induce lung eosinophilia, which in turn amplifies IL-13 production and IL-13-associated lung pathology including eosinophil-mediated ..
- TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILSDevendra K Agrawal; Fiscal Year: 2010..that intranasal administration of ClC3 siRNA prevented airway hyperresponsiveness to methacholine, BALF eosinophilia and airway inflammation in the lungs of allergic asthmatic mice...
- MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINSSteven Ackerman; Fiscal Year: 2005..of eosinophil protein), but also its secretion by activated eosinophils, elevated blood levels in patients with eosinophilia, and increased levels in sputum and BAL of asthmatics, all argue for an important role in eosinophil function...
- CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENESSteven Ackerman; Fiscal Year: 2006..IL-5 is selective for the eosinophil lineage, playing a key role in regulating blood and tissue eosinophilia in infectious and allergic processes...
- Trial of Infant Probiotic Exposure on Developing AsthmaMichael Cabana; Fiscal Year: 2007..wheezing without colds, rhinitis, and atopic dermatitis); (2) early immunologic markers for asthma development (eosinophilia, IgE); and (3) development of a T-helper phenotype (Th-1 vs Th-2)...
- gp91 phox Function in VCAM-1-dependent Lung EosinophiliaJoan Cook Mills; Fiscal Year: 2007..A component of the asthmatic response is lung eosinophilia. Eosinophilia with asthma is a risk factor for mortality from chronic obstructive pulmonary disease...
- MOLECULAR ANALYSIS OF XG28-LINKED INCONTINENTIA PIGMENTIDavid Nelson; Fiscal Year: 2000..The rash is initially vesicular with marked eosinophilia, and becomes sequentially verrucous, hyperpigmented, and finally hypopigmented...
- Pin1 regulation of prosurvival signalling in eosinophilsJames S Malter; Fiscal Year: 2010..Therefore, suppression of GM-CSF production or its prosurvival signaling could reduce pulmonary eosinophilia and the long-term morbidity of asthma...
- Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway diseaFRED DOUGLASS FINKELMAN; Fiscal Year: 2010..AHR) in mice through direct effects on airway smooth muscle cells;2) AHR is induced independently of eosinophilia and goblet cell hyperplasia;3) induction of AHR by IL-4 and IL-13 requires signaling through the type 2 IL-4R;4)..
- Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway diseaFred Finkelman; Fiscal Year: 2009..AHR) in mice through direct effects on airway smooth muscle cells; 2) AHR is induced independently of eosinophilia and goblet cell hyperplasia; 3) induction of AHR by IL-4 and IL-13 requires signaling through the type 2 IL-4R; ..
- Mouse Models of Eosinophil-Associated Lung DysfunctionNancy Lee; Fiscal Year: 2009..have demonstrated that all of the pathologies in I5/hE2 mice are absolutely dependent on the induced pulmonary eosinophilia. This proposal capitalizes on the availability of the I5/hE2 transgenic model as well as our unique eosinophil-..
- IL-13 and Eosinophilic EsophagitisMARC ROTHENBERG; Fiscal Year: 2007..We have recently established that the esophagus is normally devoid of eosinophils, and that esophageal eosinophilia occurs in association with T helper type 2 (Th2) allergic responses in the lung and gastrointestinal tract...
- IL-13 Atopic Dermatitis and Its Relationship with the Development of AsthmaTao Zheng; Fiscal Year: 2010..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
- IL-13 Atopic Dermatitis and Its Relationship with the Development of AsthmaTao Zheng; Fiscal Year: 2010..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
- IL-13 Atopic Dermatitis and Its Relationship with the Development of AsthmaTao Zheng; Fiscal Year: 2009..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
- IL-13 and Eosinophilic EsophagitisMarc E Rothenberg; Fiscal Year: 2010..We have recently established that the esophagus is normally devoid of eosinophils, and that esophageal eosinophilia occurs in association with T helper type 2 (Th2) allergic responses in the lung and gastrointestinal tract...
- 15-lipoxygenase regulation of mucosal immunity in allergic airways diseaseDouglas A Kuperman; Fiscal Year: 2010..This could provide improved protective mucosal immunity and limit the damaging effects of tissue eosinophilia. A central hypothesis and topic of investigation of this proposal is that SIgA neutralizes allergen at the site ..
- T CELL CONTROL OF AIRWAY MUCUS PRODUCTIONLauren Cohn; Fiscal Year: 2003..Th2 cells activated in the airways of mice stimulate airway eosinophilia, airway hyperresponsiveness and mucus production; features found in asthmatic patients...
- TRANSGENIC INVESTIGATIONS OF AIRWAY REMODELINGJack Elias; Fiscal Year: 2002..fibrosis, hyaluronic acid (HA) deposition and myocyte and myofibroblast hyperplasia in the absence of eosinophilia or mucus metaplasia. The Th2-type cytokines also caused subepithelial fibrosis with HA deposition...
- Eosinophil-Airway Epithelial Fas-FasL InteractionsKimm Hamann; Fiscal Year: 2004..such as eosinophils, and that in asthma this function is impaired contributing to persistent pulmonary eosinophilia. These studies will address molecular mechanisms which regulate the functional expression of FasL on airway ..
- EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASEJames Lee; Fiscal Year: 2007The pulmonary eosinophilia accompanying the pathologies of asthma has been a correlative feature recognized even in the earliest studies investigating this disease...
- Naturally occurring T regulatory cells control airway hyperresponsivenessERWIN WILLIAM GELFAND; Fiscal Year: 2010..to challenge suppress all aspects of lung allergic responses including airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and goblet cell metaplasia...