eosinophilia

Summary

Summary: Abnormal increase in eosinophils in the blood, tissues or organs.

Top Publications

  1. doi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
  2. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
  3. pmc Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines
    Cara J Bossley
    The Royal Brompton and Harefield NHS Trust, London, UK
    J Allergy Clin Immunol 129:974-82.e13. 2012
  4. ncbi Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
  5. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
  6. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
  7. doi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
  8. ncbi Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
    E A Garcia-Zepeda
    Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Med 2:449-56. 1996
  9. doi Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure
    Majed Eshki
    Department of Dermatology, Bichat Claude Bernard Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France
    Arch Dermatol 145:67-72. 2009
  10. ncbi Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006

Research Grants

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
  2. IL-13 Associated Eosinophil Lung Responses
    MARC ROTHENBERG; Fiscal Year: 2009
  3. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2010
  4. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2010
  5. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
  6. CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENES
    Steven Ackerman; Fiscal Year: 2006
  7. Trial of Infant Probiotic Exposure on Developing Asthma
    Michael Cabana; Fiscal Year: 2007
  8. gp91 phox Function in VCAM-1-dependent Lung Eosinophilia
    Joan Cook Mills; Fiscal Year: 2007
  9. MOLECULAR ANALYSIS OF XG28-LINKED INCONTINENTIA PIGMENTI
    David Nelson; Fiscal Year: 2000
  10. Pin1 regulation of prosurvival signalling in eosinophils
    James S Malter; Fiscal Year: 2010

Detail Information

Publications327 found, 100 shown here

  1. doi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..of mepolizumab, a monoclonal antibody against interleukin-5, in a rare subgroup of patients who have sputum eosinophilia and airway symptoms despite continued treatment with prednisone...
  2. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
    ..Under multivariate analysis with logistic regression, post-IVIG eosinophilia [peripheral blood (PB) eosinophils >or=4%] had an inverse correlation to KD patients with IVIG-resistance (p = ..
  3. pmc Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines
    Cara J Bossley
    The Royal Brompton and Harefield NHS Trust, London, UK
    J Allergy Clin Immunol 129:974-82.e13. 2012
    ..The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood...
  4. ncbi Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
    ..affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known causes for eosinophilia (eg, drug reactions, parasitic infections, and malignancy)...
  5. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
    ..Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma...
  6. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
    ..baumannii in modulating airway eosinophilia in a mouse model of allergic asthma. Ovalbumin (OVA)-sensitized mice were treated with live A...
  7. doi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
    To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city.
  8. ncbi Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
    E A Garcia-Zepeda
    Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Med 2:449-56. 1996
    ..To determine whether a similar molecule might play a role in human inflammatory diseases characterized by eosinophilia, we isolated the human eotaxin gene...
  9. doi Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure
    Majed Eshki
    Department of Dermatology, Bichat Claude Bernard Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France
    Arch Dermatol 145:67-72. 2009
    Factors implicated in the severity of drug reaction with eosinophilia and systemic symptoms (DRESS) have not been identified...
  10. ncbi Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006
    ..The mast cell chemotactic activity of airway secretions has not been assessed in patients with eosinophilic bronchitis...
  11. ncbi Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...
  12. doi Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome
    Sébastien Savard
    Division of Nephrology, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec Hospital, and Faculty of Medicine, Laval University, Quebec, Canada
    Am J Kidney Dis 54:e17-20. 2009
    ..On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis...
  13. ncbi Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts
    Paulo Ricardo Criado
    Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    An Bras Dermatol 87:435-49. 2012
    The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic ..
  14. pmc The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice
    Bit Na Kang
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1179-91. 2012
    ....
  15. doi Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease
    Yukiko Iino
    Department of Otolaryngology, Jichi Medical University, Saitama Medical Center, Omiya ku, Japan
    Auris Nasus Larynx 38:456-61. 2011
    ..We aimed to investigate the clinical risk factors of EOM and to establish the diagnostic criteria of EOM...
  16. ncbi Eosinophilic esophagitis
    Richard J Noel
    N Engl J Med 351:940-1. 2004
  17. ncbi Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production
    Mee Rhan Kim
    Departments of Functional Genomics, Pathology, Inflammation, Clinical Immunology, and Protein Science, Amgen Inc, Thousand Oaks, California 91302, USA
    Blood 100:2330-40. 2002
    ..The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses...
  18. doi The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug
    Yoko Kano
    Department of Dermatology, Kyorin University School of Medicine, 6 20 2 Shinkawa Mitaka, Tokyo 181 8611, Japan
    Immunol Allergy Clin North Am 29:481-501. 2009
    Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, ..
  19. ncbi TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
    J Moisan
    Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 290:L987-95. 2006
    ..These results clearly demonstrate the anti-inflammatory effect of imidazoquinolines in an allergic asthma model as well as the clinical potential of TLR7 ligands in the treatment of allergic diseases...
  20. pmc Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants
    Keir M Balla
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0380, USA
    Blood 116:3944-54. 2010
    ..Chronic exposure to helminth- related allergens resulted in profound eosinophilia, demonstrating that eosinophil responses to allergens have been conserved over evolution...
  21. ncbi Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    G J Braunstahl
    Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Allergy Clin Immunol 107:469-76. 2001
    ..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...
  22. doi Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
    M M Walker
    Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College, London, UK
    Aliment Pharmacol Ther 29:765-73. 2009
    ..Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function...
  23. ncbi Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
    During the last decade, clinical practice saw a rapid increase of patients with esophageal eosinophilia who were thought to have gastroesophageal reflux disease (GERD) but who did not respond to medical and/or surgical GERD management...
  24. doi Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related
    David W Reid
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 13:799-809. 2008
    ..In particular, it is not known whether BDR is associated with underlying airway eosinophilia and whether BDR is predictive of a better response to inhaled corticosteroid (ICS) treatment.
  25. pmc Toxocariasis and ingestion of raw cow liver in patients with eosinophilia
    Dongil Choi
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Korean J Parasitol 46:139-43. 2008
    ..We evaluated the relationship between toxocariasis and the ingestion of raw meat in patients with eosinophilia of unknown etiology...
  26. doi PGE(2) decreases muscle cell proliferation in patients with non-asthmatic eosinophilic bronchitis
    Beatriz Sastre
    Immunology Department, IIS Fundación Jiménez Díaz, Madrid, Spain
    Prostaglandins Other Lipid Mediat 95:11-8. 2011
    Non-asthmatic eosinophilic bronchitis (NAEB) is characterized by chronic cough and sputum eosinophilia without bronchial hyperresponsiveness...
  27. ncbi Disseminated colon cancer with severe peripheral blood eosinophilia and elevated serum levels of interleukine-2, interleukine-3, interleukine-5, and GM-CSF
    George K Anagnostopoulos
    J Surg Oncol 89:273-5. 2005
  28. ncbi Severe acute hepatitis in the DRESS syndrome: Report of two cases
    Sabela Lens
    Institut de Malalties Digestives, Hospital Clinic, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Ann Hepatol 9:198-201. 2010
    The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, also known as DIHS (drug-induced hypersensitivity syndrome), is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can ..
  29. doi Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine
    Tulio Queto
    Laboratório de Fisiopatologia Humana, IFF, FIOCRUZ, Rio de Janeiro, Brazil
    Am J Respir Crit Care Med 181:429-37. 2010
    The mechanism of action of diethylcarbamazine (DEC), an antifilarial drug effective against tropical pulmonary eosinophilia, remains controversial. DEC effects on microfilariae depend on inducible NO synthase (iNOS)...
  30. ncbi Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals
    K P Lan
    Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    J Helminthol 78:311-7. 2004
    ..Although eosinophilia is an important clinical manifestation of A...
  31. doi Natural killer cells accumulate in lung-draining lymph nodes and regulate airway eosinophilia in a murine model of asthma
    C Ple
    INSERM, Institut National de la Santé et de la Recherche Médicale U774, Lille, France
    Scand J Immunol 72:118-27. 2010
    ..Anti-ASGM1 antibody treatment depleted most NK cells and decreased bronchoalveolar lavage eosinophilia but did not modify airway responsiveness...
  32. doi Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation
    M Mennicke
    University Clinic for Visceral Surgery and Medicine, Bern University Hospital, and University of Bern, Switzerland
    Am J Transplant 9:2197-202. 2009
    DRESS syndrome (drug rash with eosinophilia and systemic symptoms) is a rare drug hypersensitivity reaction with a significant mortality...
  33. pmc IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis
    Todd M Wilson
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    J Allergy Clin Immunol 128:1086-92.e1-3. 2011
    IL-5 plays a central role in the development and maintenance of eosinophilia (EO) and eosinophil activation in a wide variety of eosinophilic disorders...
  34. doi First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis
    Guillaume Roquin
    Service d Hepato gastro enterologie, CHU Angers, Angers, France
    Ann Pharmacother 44:1998-2000. 2010
    To report a case of lamotrigine-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome with pancreatitis as the initial visceral involvement.
  35. ncbi Prevalence of allergic rhinitis and nasal smear eosinophilia in 11- to 15 yr-old children in Shiraz
    Sara Miri
    Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Pediatr Allergy Immunol 17:519-23. 2006
    ..The objective of this study was to determine the prevalence of nasal symptoms and signs of AR and nasal smear eosinophilia in 11- to 15-yr-old children in Shiraz...
  36. pmc Practical approach to the patient with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:39-44. 2010
    Markedly increased blood eosinophilia (ie, > or =1.5 x 10(9)/L), whether discovered fortuitously or found with signs and symptoms of associated organ involvement, commands diagnostic evaluation and often therapeutic interventions...
  37. ncbi Eosinophilic esophagitis: it's not just kid's stuff
    Victor L Fox
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 56:260-70. 2002
  38. ncbi Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
    Hiromi Okigami
    Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Disease Research, Japan
    Eur J Pharmacol 559:202-9. 2007
    ..These data support the use of small molecule VLA-4 antagonists in the treatment of relevant diseases, such as asthma, atopic dermatitis, or allergic rhinitis...
  39. ncbi Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
    C E Brightling
    Glenfield Hospital, Leicester, United Kingdom and Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 162:878-82. 2000
    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but in contrast to asthma there is no variable airflow obstruction or airway hyperresponsiveness...
  40. ncbi The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait
    M Khadadah
    Department of Medicine, Faculty of Medicine, Kuwait University, Safat
    J Asthma 37:481-8. 2000
    There is evidence that elevated serum immunoglobulin E (IgE) and eosinophilia correlate well with allergic skin test reactivity. These parameters have been used as alternative methods to characterize atopic subjects...
  41. doi Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking
    S A Walsh
    Department of Dermatology, King s College Hospital, Denmark Hill, London, UK
    Clin Exp Dermatol 36:6-11. 2011
    Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a severe medication-induced adverse reaction, which has cutaneous, haematological and solid-organ features...
  42. pmc Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update
    Ayalew Tefferi
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 85:158-64. 2010
    Acquired eosinophilia is operationally categorized into secondary, clonal, and idiopathic types. Causes of secondary eosinophilia include parasite infections, allergic or vasculitis conditions, drugs, and lymphoma...
  43. pmc TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection
    Mingjian Fei
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 108:5360-5. 2011
    ..Our study identifies TNF-α as a molecular switch that orchestrates a sequence of events in DCs and CD4 T cells that promote neutrophilic airway inflammation...
  44. ncbi A presumptive case of toxocariasis associated with eosinophilic pleural effusion: case report and literature review
    Mahi Lakshmi Ashwath
    Department of Internal Medicine, Section of Infectious Diseases, Mercer University School of Medicine, Macon, Georgia 31201, USA
    Am J Trop Med Hyg 71:764. 2004
    ..The symptoms of this patient responded promptly to a nonsteroidal anti-inflammatory medication (naproxen). This is only the fourth reported case of a pleural effusion associated with Toxocara...
  45. pmc Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract
    Dagmar Simon
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 126:3-13; quiz 14-5. 2010
    ..An approach to determining the causal role of eosinophils in these diseases is presented. Recent findings concerning molecular diagnosis, cause, and treatment are discussed...
  46. ncbi Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis
    B Sastre
    Immunology Department Fundación Jiménez Díaz Capio, CIBERES ISCIII, Madrid, Spain
    Allergy 63:58-66. 2008
    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness...
  47. ncbi The comparision of IgG antibodies specific to Toxocara spp. among eosinophilic and non-eosinophilic groups
    Senem Yaman Karadam
    Adnan Menderes University, Medical School Department of Microbiology and Clinical Microbiology, Aydin, Turkey
    New Microbiol 31:113-6. 2008
    Toxocariasis is one of the most frequently reported helminth infections worldwide. Eosinophilia is a common finding of parasitic infections. This study assessed the levels of IgG antibodies specific to Toxocara spp...
  48. ncbi Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways
    Atsuko Kibe
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Crit Care Med 167:50-6. 2003
    ..Control of steroid-resistant features induced by IL-13, including AHR and mucus production, may provide new therapeutic modalities for asthma...
  49. doi Retrospective analysis of drug-induced hypersensitivity syndrome: a study of 27 patients
    Chia Chun Ang
    Department of Dermatology, Changi General Hospital, Singapore
    J Am Acad Dermatol 63:219-27. 2010
    ..Previous reports regarding the characteristics of patients with drug-induced hypersensitivity syndrome (DIHS) are mostly limited to small case reports and drug-specific case series, mainly involving Caucasian patients...
  50. ncbi Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges
    F Taki
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Exp Allergy 37:599-607. 2007
    ..It is generally considered that eosinophilic inflammation and hyper-reactivity to methacholine in airways are fundamental to the pathophysiology of bronchial asthma...
  51. ncbi Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment
    Ayalew Tefferi
    Department of Internal Medicine and Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:75-83. 2005
    Acquired blood eosinophilia is considered either a primary or a secondary phenomenon...
  52. ncbi Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis
    Amir F Kagalwalla
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1097-102. 2006
    ..However, compliance with an exclusive, poor-tasting liquid formulation is difficult...
  53. ncbi Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T6741 mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy
    Hiroaki Ohnishi
    Br J Haematol 134:547-9. 2006
  54. ncbi Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbumin
    Xiaobing Han
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Eur J Immunol 34:981-9. 2004
    ..Moreover, adoptive transfer of iIDC, but not iNDC, could inhibit systemic and local eosinophilia induced by allergen exposure...
  55. pmc Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?
    Fouad El Sayed
    Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon
    Head Face Med 2:32. 2006
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region...
  56. ncbi Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  57. ncbi IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 120:1292-300. 2007
    ..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal ..
  58. ncbi Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis
    Shweta Saxena
    Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, India
    J Allergy Clin Immunol 111:1001-7. 2003
    ..Studies from our group have shown a protective role of pulmonary surfactant protein A (SP-A) against lung allergy and infections caused by Aspergillus fumigatus...
  59. doi Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection
    Elizabeth S Magalhães
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    FASEB J 23:1262-71. 2009
    ..of inflammatory diseases, including asthma, in which it enhances airway hypersensitivity and tissue eosinophilia. Herein, we investigated the role of MIF in eosinophilopoiesis and tissue eosinophilia using Schistosoma ..
  60. pmc Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge
    T R Johnson
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
    J Virol 72:2871-80. 1998
    ..and presentation is an important factor in promoting Th2-like immune responses, including the induction of lung eosinophilia. The ability of RSV to secrete G protein may therefore represent a viral strategy for immunomodulation and be a ..
  61. ncbi Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
    Jonathan E Markowitz
    Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:777-82. 2003
    ..Corticosteroids, cromolyn, and elemental diet have all been reported as successful treatments for EoE. In this study, we sought to accurately define a population of patients with EoE and then assess their response to elemental diet...
  62. ncbi Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease
    Victor Matheu
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, BMC 111, Lund 22184, Sweden
    J Allergy Clin Immunol 112:585-92. 2003
    ..A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated...
  63. pmc Helminth infection and eosinophilia and the risk of Plasmodium falciparum malaria in 1- to 6-year-old children in a malaria endemic area
    Philip Bejon
    Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    PLoS Negl Trop Dis 2:e164. 2008
    ..Animal models suggest that helminth infections may increase susceptibility to malaria, but epidemiological data has been limited and contradictory...
  64. ncbi Eosinophilia: secondary, clonal and idiopathic
    Ayalew Tefferi
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Br J Haematol 133:468-92. 2006
    Blood eosinophilia signifies either a cytokine-mediated reactive phenomenon (secondary) or an integral phenotype of an underlying haematological neoplasm (primary)...
  65. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
    ..We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling...
  66. ncbi Immune expulsion of the trichostrongylid Cooperia oncophora is associated with increased eosinophilia and mucosal IgA
    K Kanobana
    Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80 165, 3508, Utrecht, TD, The Netherlands
    Int J Parasitol 32:1389-98. 2002
    ..Our results describe the involvement of both eosinophils and mucosal IgA in the regulation of C. oncophora expulsion and suggest the development of a Th2 effector immune response...
  67. ncbi Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma
    Chih Lung Chen
    Division of Biomaterial and Tissue Engineering, Industrial Technology Research Institute, Hsing Chu, Taiwan, Republic of China
    J Allergy Clin Immunol 118:105-12. 2006
    ..Serine proteases such as mast cell tryptase and certain allergens are important in the pathogenesis of allergic inflammation of asthma...
  68. ncbi Activated mucosal mast cells differentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux disease
    Richard Kirsch
    Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 44:20-6. 2007
    ..To evaluate the utility of activated mucosal mast cells (MC) in the differential diagnosis of eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD)...
  69. pmc Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children
    P A Steerenberg
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Thorax 58:242-5. 2003
    ..Exhaled nitric oxide (eNO) may serve as a non-invasive marker of airway inflammation but its relationship with other commonly used measures has not been evaluated...
  70. ncbi MRI findings of focal eosinophilic liver diseases
    Young Kon Kim
    Department of Diagnostic Radiology, Chonbuk National University Hospital, Chonju, Korea
    AJR Am J Roentgenol 184:1541-8. 2005
    ..The purpose of this study was to describe the MRI findings of focal eosinophilic infiltration and eosinophilic abscess of the liver...
  71. doi Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis
    S Siddiqui
    Institute of Lung Health, Leicester, UK
    Allergy 64:951-8. 2009
    ..Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometry differs between asthma and nonasthmatic EB is uncertain...
  72. doi Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine strain of Francisella tularensis
    R KuoLee
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    Clin Exp Allergy 38:1003-15. 2008
    ....
  73. doi Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature
    Lindsay Bischoff
    Jefferson Medical College, Philadelphia PA, 19107, USA
    Int J Dermatol 47:29-35. 2008
    ..Eosinophilic fasciitis is a rare scleroderma-like illness. The clinical spectrum of the disease has evolved since its initial description...
  74. ncbi Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry
    Jesus R Guajardo
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 141:576-81. 2002
    ....
  75. pmc The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:7958-68. 2008
    ..respiratory syncytial virus (FI-RSV) vaccine experienced enhanced respiratory disease, including pulmonary eosinophilia, after contracting a natural RSV infection...
  76. ncbi Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis
    D A Schwartz
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dig Dis Sci 46:1787-90. 2001
    ..To our knowledge, this is the first use of montelukast as a steroid sparing agent for eosinophilic gastroenteritis...
  77. ncbi Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia
    D Robert Webb
    Allergy and Asthma Research Associates, Kirkland, Washington 98034, USA
    Ann Allergy Asthma Immunol 88:385-90. 2002
    ..Objective: To evaluate the efficacy of intranasal fluticasone propionate (FP) in the treatment of patients with perennial nonallergic rhinitis, with and without nasal eosinophilia.
  78. ncbi Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
    Alex Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    Gastroenterology 125:1660-9. 2003
    ..Before this study, the natural course of eosinophilic esophagitis had not been defined and information regarding potential long-term risks was lacking...
  79. ncbi A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lip
    Hiromi Suzuki
    Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Dermatol 32:991-5. 2005
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare...
  80. ncbi Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis
    Soon Bahrami
    Department of Pathology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Arch Dermatol 142:155-61. 2006
    To determine whether tissue eosinophilia is a reliable indicator of a drug-induced etiology in biopsy samples demonstrating leukocytoclastic vasculitis.
  81. ncbi Focal eosinophilic necrosis versus metastasis in the liver: the usefulness of two-phase dynamic CT
    Jin Hur
    Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine and YongDong Severance Hospital, 146 92, Dogok dong, Kangnam Ku, Seoul 135 270, South Korea
    AJR Am J Roentgenol 184:1085-90. 2005
    ..Two-phase dynamic CT was found to be useful at differentiating focal eosinophilic necrosis from metastasis...
  82. ncbi Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice
    M D Inman
    Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 21:473-9. 1999
    ..05). We observed that allergen-induced airway eosinophilia is accompanied by increases in BM eosinophil progenitors, indicating that in this model, increased eosinophil ..
  83. ncbi Nonallergic rhinitis with eosinophilia syndrome
    Anne K Ellis
    Curr Allergy Asthma Rep 6:215-20. 2006
    Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis ..
  84. doi Effect of omalizumab on peripheral blood eosinophilia in allergic asthma
    M Massanari
    Novartis Pharmaceuticals Corp, East Hanover, NJ 07936 1080, USA
    Respir Med 104:188-96. 2010
    b>Eosinophilia is an established marker of asthma-related inflammation...
  85. ncbi Substance P and the neurokinin-1 receptor in relation to eosinophilia in ulcerative colitis
    Maria Jonsson
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, SE 90187 Umea, Sweden
    Peptides 26:799-814. 2005
    ..Furthermore, for the majority of cases where there is marked derangement of the mucosa, it is apparent that there is an upregulation of the NK-1 receptor in the epithelium in parallel with the infiltration of the eosinophils...
  86. ncbi Eosinophilic meningitis
    Vincent Lo Re
    Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med 114:217-23. 2003
    ..It is defined by the presence of 10 or more eosinophils/microL in the cerebrospinal fluid (CSF) or a CSF eosinophilia of at least 10%...
  87. ncbi Hepatic involvement of visceral larva migrans due to Toxocara canis: a case report--CT and MR findings
    Koichiro Azuma
    Department of Radiology, Kameda Medical Center, Kamogawa, Chiba, Japan
    Radiat Med 20:89-92. 2002
    ..A 44-year-old man presented with chills, eruptions, marked leukocytosis (31,400/microlitter), and eosinophilia (eosinophil, 72%). Multiple liver nodules were detected as low-density lesions on computed tomography (CT)...
  88. doi Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany
    Felix Luessi
    Department of Neurology, Johannes Gutenberg University Mainz, D 55101 Mainz, Germany
    J Travel Med 16:292-4. 2009
    ..The presence of a compatible epidemiologic history and eosinophilia in cerebrospinal fluid (CSF) lead to the diagnosis, which was confirmed by detection of specific antibodies...
  89. ncbi Bullous "cellulitis" with eosinophilia: case report and review of Wells' syndrome in childhood
    Amy E Gilliam
    Department of Dermatology, University of California, 1701 Divisadero St, 3rd Floor, San Francisco, CA 94115, USA
    Pediatrics 116:e149-55. 2005
    ..onset of edematous erythematous plaques associated with bullae on her extremities and accompanied by peripheral eosinophilia. She was afebrile, and the skin lesions were pruritic but not tender...
  90. ncbi Focal eosinophilic infiltration in the liver: radiologic findings and clinical course
    S Y Yoo
    Department of Radiology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Abdom Imaging 28:326-32. 2003
    ..We investigated the radiologic findings and clinical course of focal eosinophilic infiltration in the liver...
  91. ncbi Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes
    Gerald E Hancock
    Department of Immunology Research, Wyeth Vaccines, West Henrietta, New York 14586 9728, USA
    J Med Virol 70:301-8. 2003
    ..As demonstrated by IL-5-dependent pulmonary eosinophilia after challenge and serum anti-G protein IgG1 to IgG2 ratios, highly purified native G protein sensitized all ..
  92. doi Relationships between eosinophilia, anti-Fasciola IgG, and IgM rheumatoid factors, in urban and rural areas of north-western Spain
    A Sanchez-Andrade
    Rheumatology Department, Hospital Xeral Calde, Dr Ochoa, S N, 27004 Lugo, Spain
    Ann Trop Med Parasitol 102:489-98. 2008
    ..patients attending a hospital in Lugo, in north-western Spain, to investigate possible relationships between eosinophilia, IgG antibodies against the parasitic helminth Fasciola hepatica, and IgM rheumatoid factors (IgM-RF)...
  93. doi Metastasis versus focal eosinophilic infiltration of the liver in patients with extrahepatic abdominal cancer: an evaluation with gadobenate dimeglumine-enhanced magnetic resonance imaging
    Mi Suk Park
    Department of Diagnostic Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University of Medicine, Seoul, Korea
    J Comput Assist Tomogr 33:119-24. 2009
    ..To determine the performance of gadobenate dimeglumine (Gd-BOPTA)-enhanced magnetic resonance imaging (MRI) to differentiate focal eosinophilic infiltration (FEI) from metastasis...
  94. ncbi A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice
    Masato Komai
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
    J Pharmacol Sci 112:203-13. 2010
    ..Therefore, a CCR3 antagonist may be useful in the treatment of airway remodeling, especially subepithelial and peribronchial fibrosis, in allergic asthma...
  95. ncbi Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice
    Mahmoud A Pouladi
    McMaster University, Department of Pathology and Molecular Medicine, Health Sciences Centre, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Am J Respir Cell Mol Biol 30:84-90. 2004
    ..The ensuing inflammatory response is characterized by a Th2 cytokine profile, OVA-specific IgE, and airway eosinophilia. Using real-time, quantitative reverse transcriptase-polymerase chain reaction we assessed MMP-12 mRNA ..
  96. ncbi Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge
    Nathalie Etchart
    Lung Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:1136-44. 2006
    ..These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection...
  97. ncbi MR findings in eosinophilic infiltration of the liver
    Joo Sung Sun
    Department of Diagnostic Radiology, Ajou University, College of Medicine, Kyunggido, Korea
    J Comput Assist Tomogr 29:191-4. 2005
    ..This study describes the findings of magnetic resonance imaging (MRI) of focal eosinophilic infiltration of the liver...
  98. doi Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine
    Jeremy Rosenbaum
    Department of Gastroenterology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 46:193-6. 2010
    ..infectious causes are the most important to exclude in a timely manner and drug rash and eosinophilia with systemic symptoms (DRESS) is another differential diagnosis that should be considered in children...
  99. doi Isomaltitol exacerbates neutrophilia but reduces eosinophilia: new insights into the sephadex model of lung inflammation
    Chamilly Evaldsson
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, Linkoping, Sweden
    Int Arch Allergy Immunol 154:286-94. 2011
    ..The Sephadex-induced lung inflammation model was considered a suitablemodel due to the significant changes in global inflammatory endpoints seen upon provocation with Sephadex...
  100. ncbi Nonallergic rhinitis with eosinophilia syndrome and related disorders
    Anne K Ellis
    Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
    Clin Allergy Immunol 19:87-100. 2007
    ..Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or LT receptor antagonists as an adjuvant...
  101. ncbi Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining
    P Kiehl
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
    Br J Dermatol 145:720-9. 2001
    The frequency and amount of tissue eosinophilia in spontaneous lesions of acute and chronic atopic dermatitis (AD) are still a matter of controversy, and little is known about the distribution of eosinophilia in skin.

Research Grants87

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
    ..In this study the inflammation associated with asthma will be studied using both "traditional" markers such as eosinophilia, exhaled NO (eNO) and sinus CT score; as well as measurements of cytokines in serum and leukotrienes in urine...
  2. IL-13 Associated Eosinophil Lung Responses
    MARC ROTHENBERG; Fiscal Year: 2009
    ..g. the eotaxins), and in conjunction with IL-5, these chemokines induce lung eosinophilia, which in turn amplifies IL-13 production and IL-13-associated lung pathology including eosinophil-mediated ..
  3. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2010
    ..g. the eotaxins), and in conjunction with IL-5, these chemokines induce lung eosinophilia, which in turn amplifies IL-13 production and IL-13-associated lung pathology including eosinophil-mediated ..
  4. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2010
    ..that intranasal administration of ClC3 siRNA prevented airway hyperresponsiveness to methacholine, BALF eosinophilia and airway inflammation in the lungs of allergic asthmatic mice...
  5. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
    ..of eosinophil protein), but also its secretion by activated eosinophils, elevated blood levels in patients with eosinophilia, and increased levels in sputum and BAL of asthmatics, all argue for an important role in eosinophil function...
  6. CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENES
    Steven Ackerman; Fiscal Year: 2006
    ..IL-5 is selective for the eosinophil lineage, playing a key role in regulating blood and tissue eosinophilia in infectious and allergic processes...
  7. Trial of Infant Probiotic Exposure on Developing Asthma
    Michael Cabana; Fiscal Year: 2007
    ..wheezing without colds, rhinitis, and atopic dermatitis); (2) early immunologic markers for asthma development (eosinophilia, IgE); and (3) development of a T-helper phenotype (Th-1 vs Th-2)...
  8. gp91 phox Function in VCAM-1-dependent Lung Eosinophilia
    Joan Cook Mills; Fiscal Year: 2007
    ..A component of the asthmatic response is lung eosinophilia. Eosinophilia with asthma is a risk factor for mortality from chronic obstructive pulmonary disease...
  9. MOLECULAR ANALYSIS OF XG28-LINKED INCONTINENTIA PIGMENTI
    David Nelson; Fiscal Year: 2000
    ..The rash is initially vesicular with marked eosinophilia, and becomes sequentially verrucous, hyperpigmented, and finally hypopigmented...
  10. Pin1 regulation of prosurvival signalling in eosinophils
    James S Malter; Fiscal Year: 2010
    ..Therefore, suppression of GM-CSF production or its prosurvival signaling could reduce pulmonary eosinophilia and the long-term morbidity of asthma...
  11. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..AHR) in mice through direct effects on airway smooth muscle cells;2) AHR is induced independently of eosinophilia and goblet cell hyperplasia;3) induction of AHR by IL-4 and IL-13 requires signaling through the type 2 IL-4R;4)..
  12. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    Fred Finkelman; Fiscal Year: 2009
    ..AHR) in mice through direct effects on airway smooth muscle cells; 2) AHR is induced independently of eosinophilia and goblet cell hyperplasia; 3) induction of AHR by IL-4 and IL-13 requires signaling through the type 2 IL-4R; ..
  13. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy Lee; Fiscal Year: 2009
    ..have demonstrated that all of the pathologies in I5/hE2 mice are absolutely dependent on the induced pulmonary eosinophilia. This proposal capitalizes on the availability of the I5/hE2 transgenic model as well as our unique eosinophil-..
  14. IL-13 and Eosinophilic Esophagitis
    MARC ROTHENBERG; Fiscal Year: 2007
    ..We have recently established that the esophagus is normally devoid of eosinophils, and that esophageal eosinophilia occurs in association with T helper type 2 (Th2) allergic responses in the lung and gastrointestinal tract...
  15. IL-13 and Eosinophilic Esophagitis
    Marc E Rothenberg; Fiscal Year: 2010
    ..We have recently established that the esophagus is normally devoid of eosinophils, and that esophageal eosinophilia occurs in association with T helper type 2 (Th2) allergic responses in the lung and gastrointestinal tract...
  16. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2010
    ..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
  17. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2009
    ..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
  18. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2010
    ..AD and asthma share some common immunological features, including elevated IgE, peripheral and lesional eosinophilia, Th2 cytokine elevation, epithelial dysfunction and similar allergenic triggers...
  19. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2010
    ..This could provide improved protective mucosal immunity and limit the damaging effects of tissue eosinophilia. A central hypothesis and topic of investigation of this proposal is that SIgA neutralizes allergen at the site ..
  20. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2003
    ..Th2 cells activated in the airways of mice stimulate airway eosinophilia, airway hyperresponsiveness and mucus production; features found in asthmatic patients...
  21. TRANSGENIC INVESTIGATIONS OF AIRWAY REMODELING
    Jack Elias; Fiscal Year: 2002
    ..fibrosis, hyaluronic acid (HA) deposition and myocyte and myofibroblast hyperplasia in the absence of eosinophilia or mucus metaplasia. The Th2-type cytokines also caused subepithelial fibrosis with HA deposition...
  22. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
    ..such as eosinophils, and that in asthma this function is impaired contributing to persistent pulmonary eosinophilia. These studies will address molecular mechanisms which regulate the functional expression of FasL on airway ..
  23. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2007
    The pulmonary eosinophilia accompanying the pathologies of asthma has been a correlative feature recognized even in the earliest studies investigating this disease...
  24. Naturally occurring T regulatory cells control airway hyperresponsiveness
    ERWIN WILLIAM GELFAND; Fiscal Year: 2010
    ..to challenge suppress all aspects of lung allergic responses including airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and goblet cell metaplasia...