hypoalbuminemia

Summary

Summary: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).

Top Publications

  1. ncbi Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD
    Bruce A Cooper
    Department of Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
    Am J Kidney Dis 43:61-6. 2004
  2. ncbi Intravenous albumin administration and body water balance in critically ill patients
    Daniel Ferreira da Cunha
    Nutrition 19:157-8. 2003
  3. ncbi [Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage]
    Ping Xue
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Zhong Xi Yi Jie He Xue Bao 3:443-5. 2005
  4. ncbi Improving albumin levels among hemodialysis patients
    Nathan W Levin
    Am J Kidney Dis 48:171-3. 2006
  5. pmc Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 89:1028-30. 2003
  6. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
  7. ncbi Elevated C-reactive protein and hypoalbuminemia measured before resection of colorectal liver metastases predict postoperative survival
    Takashi Kobayashi
    Department of Surgery, Showa General Hospital, Kodaira, Tokyo, Japan
    Dig Surg 27:285-90. 2010
  8. ncbi Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation
    Kazuhiro Nakamura
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Clin Chim Acta 388:51-8. 2008
  9. ncbi Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap
    Mark Feldman
    Departments of Internal Medicine and Pathology, Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Lab Clin Med 146:317-20. 2005
  10. ncbi Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study
    Marc Jacques Dubois
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:2536-40. 2006

Detail Information

Publications215 found, 100 shown here

  1. ncbi Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD
    Bruce A Cooper
    Department of Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
    Am J Kidney Dis 43:61-6. 2004
    ..However, previous studies were unable to differentiate between true protein malnutrition and hypoalbuminemia.
  2. ncbi Intravenous albumin administration and body water balance in critically ill patients
    Daniel Ferreira da Cunha
    Nutrition 19:157-8. 2003
  3. ncbi [Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage]
    Ping Xue
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Zhong Xi Yi Jie He Xue Bao 3:443-5. 2005
    ..the occurring mechanism and clinical characteristics of severe acute pancreatitis (SAP) associated with hypoalbuminemia in early stage and its influence on prognosis of SAP and the preventive and therapeutic management of this ..
  4. ncbi Improving albumin levels among hemodialysis patients
    Nathan W Levin
    Am J Kidney Dis 48:171-3. 2006
  5. pmc Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 89:1028-30. 2003
    ..001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised...
  6. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
    To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients.
  7. ncbi Elevated C-reactive protein and hypoalbuminemia measured before resection of colorectal liver metastases predict postoperative survival
    Takashi Kobayashi
    Department of Surgery, Showa General Hospital, Kodaira, Tokyo, Japan
    Dig Surg 27:285-90. 2010
    ..Few studies have investigated whether the Glasgow Prognostic Score (GPS), an inflammation-based prognostic score measured before resection of colorectal liver metastasis (CRLM), can predict postoperative survival...
  8. ncbi Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation
    Kazuhiro Nakamura
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Clin Chim Acta 388:51-8. 2008
    ..The introduction of ATX measurements into clinical laboratory testing is urgently needed...
  9. ncbi Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap
    Mark Feldman
    Departments of Internal Medicine and Pathology, Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Lab Clin Med 146:317-20. 2005
    Conflicting data exist as to what extent hypoalbuminemia reduces the anion gap; estimates range from 1.5 to 2.5 mM per g/dL decrease in serum albumin.
  10. ncbi Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study
    Marc Jacques Dubois
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:2536-40. 2006
    To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients.
  11. ncbi Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy
    Michael Danielski
    Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 42:286-94. 2003
    b>Hypoalbuminemia is a powerful predictor of cardiovascular mortality in maintenance hemodialysis patients...
  12. pmc Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease
    Percy Tumbale
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, North Carolina, USA
    Nat Struct Mol Biol 18:1189-95. 2011
    ....
  13. ncbi Inflammatory factors for hypoalbuminemia in Japanese peritoneal dialysis patients
    Masuyo Shioya
    Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Nephrology (Carlton) 18:539-44. 2013
    ..However, the relationship between peritoneal inflammation, peritoneal transport properties and hypoalbuminaemia has not been fully elucidated...
  14. ncbi Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan women
    Christine N Dao
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    AIDS Res Hum Retroviruses 27:1149-55. 2011
    ..Among women with a CD4 cell count >50 cells/μl, hypoalbuminemia was also a significant predictor of mortality (aHR=3.7, 95% CI 1.4-9.8)...
  15. ncbi Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy
    Chang Yu Wang
    National Kaohsiung University of Applied Sciences, Taiwan
    Radiother Oncol 92:270-5. 2009
    ..We evaluate if C-reactive protein (CRP) is an objective biomarker of esophageal cancer in patients undergoing radiotherapy...
  16. ncbi The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients
    Marta Ulldemolins
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 50:99-110. 2011
    ..Further research that defines dosing regimens that account for such altered pharmacokinetics is recommended...
  17. ncbi Mutations and polymorphisms of the gene of the major human blood protein, serum albumin
    Lorenzo Minchiotti
    Department of Biochemistry A Castellani, University of Pavia, Pavia, Italy
    Hum Mutat 29:1007-16. 2008
    ..Allotypes from three of the point mutations become N-glycosylated and one C-terminal frameshift mutation shows O-glycosylation...
  18. ncbi Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: a multi-institutional study
    Derek B Hennessey
    Department of Surgery, Wexford General Hospital, Wexford, Ireland
    Ann Surg 252:325-9. 2010
    ..Surgical site infection (SSI) is an infection occurring in an incisional wound within 30 days of surgery and significantly effects patient recovery and hospital resources...
  19. ncbi Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis
    Kim I de la Cruz
    Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Ann Thorac Surg 91:671-5. 2011
    b>Hypoalbuminemia is associated with increased morbidity in surgical patients. The impact of low albumin level on survival in cardiac surgical patients is unknown...
  20. ncbi Hypoalbuminemia is a predictor of delayed postoperative bowel function and poor surgical outcomes in right-sided colon cancer patients
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand
    Asia Pac J Clin Nutr 16:213-7. 2007
    ..To determine the relationship between preoperative serum albumin and postoperative bowel function as well as surgical outcomes in right-sided colon cancer patients...
  21. ncbi Preoperative hypoalbuminemia is associated with adverse outcomes after ileoanal pouch surgery
    Pasha J Nisar
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Inflamm Bowel Dis 18:1034-41. 2012
    ..This study examines the association between preoperative albumin and ileoanal pouch (IPAA) outcomes and the utility of serum albumin in the decision to perform a staged IPAA with an initial subtotal colectomy...
  22. ncbi Hypoalbuminemia is an important risk factor of hypotension during hemodialysis
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hemodial Int 10:S10-5. 2006
    ..598, p=0.0016). From these data, we conclude that hypoalbuminemia is a major risk factor of hypotension during HD.
  23. ncbi [Some consequences of systemic inflammatory response in the pathogenesis of aggravation of outcomes of combined radiation and thermal injuries]
    R S Budagov
    Radiats Biol Radioecol 45:191-5. 2005
    ..15th day) was characterized with expressed postradiation leikopenia and thrombocytopenia, was accompanied by hypoalbuminemia and hyperfibrinogenemia with a moderate raise in serum ALT activity...
  24. pmc Serum albumin level correlates with disease severity in patients with Hemorrhagic Fever with Renal Syndrome
    Young Ok Kim
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 18:696-700. 2003
    b>Hypoalbuminemia frequently occurs in Hemorrhagic Fever with Renal Syndrome (HFRS), but clinical significance of hypoalbuminemia is not well known...
  25. ncbi Detection of a novel splicing mutation causing analbuminemia in a Libyan family
    Amina Bibi
    Biochemistry Laboratory, Children s Hospital, Bab Saadoun Square, 1007, Tunis, Tunisia
    Clin Biochem 45:1183-6. 2012
    ..Analbuminemia is a very rare autosomal recessive disorder. It is an allelic heterogeneous defect caused by a variety of mutations within the albumin gene. We describe in this report two new cases of analbuminemia in Libyans...
  26. ncbi Anemia, hypoalbuminemia, and renal impairment as predictors of bleeding complications in patients receiving anticoagulation therapy for nonvalvular atrial fibrillation: a secondary analysis
    Ahmed H Abdelhafiz
    Department of Geriatric Medicine, Rotherham General Hospital, Rotherham, 560 2UD, United Kingdom
    Clin Ther 31:1534-9. 2009
    The aim of this analysis was to evaluate the roles of anemia, hypoalbuminemia, and renal impairment as independent predictors of bleeding in patients with nonvalvular atrial fibrillation (NVAF) receiving anticoagulation therapy with ..
  27. ncbi A simple risk score to predict in-hospital death of elderly patients with acute decompensated heart failure--hypoalbuminemia as an additional prognostic factor
    Yoshiharu Kinugasa
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Circ J 73:2276-81. 2009
    ..Risk stratification for elderly patients with acute decompensated heart failure (ADHF) may help clinicians to select the appropriate therapy and raise the quality of care...
  28. ncbi Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia
    Thitima Doungngern
    Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Am J Crit Care 21:280-6. 2012
    ..One common use of albumin is to promote diuresis. Objectives To compare urine output in patients treated with furosemide with and without albumin and to assess other variables possibly associated with enhanced diuresis...
  29. ncbi Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding
    Carlos Alfredo González Infantino
    Hospital de Clinicas Jose de San Martin, School of Medicine, Buenos Aires University, Buenos Aires, Argentina
    Nutrition 29:497-501. 2013
    ..To determine the association of in-hospital mortality in patients with enteral feeding to their glycemic status (normoglycemia, new hyperglycemia, or diabetes) and their levels of serum albumin...
  30. ncbi A novel splicing mutation causes analbuminemia in a Portuguese boy
    Gianluca Caridi
    Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini IRCCS, Genova, Italy
    Mol Genet Metab 105:479-83. 2012
    ..DNA and cDNA sequence analysis established the diagnosis of congenital analbuminemia in the proband. The effects of the so far identified splice-site mutations in the albumin gene are discussed...
  31. ncbi Score based on hypoalbuminemia and elevated C-reactive protein predicts survival in patients with advanced gastrointestinal cancer
    Maqsood M Elahi
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 48:171-3. 2004
    ..The aim of this study is to assess the value of the combination of hypoalbuminemia and an elevated circulating concentration of C-reactive protein as a prognostic score in patients with ..
  32. ncbi Preoperative hypoalbuminemia is a major risk factor for acute kidney injury following off-pump coronary artery bypass surgery
    Eun Ho Lee
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul, 138 736, Korea
    Intensive Care Med 38:1478-86. 2012
    ..Logistic regression and propensity analyses were performed to evaluate the association between preoperative low serum albumin level and postoperative AKI...
  33. ncbi Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 42:256-63. 2003
    ..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
  34. ncbi A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia
    Nada Al Tassan
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Hum Mutat 33:351-4. 2012
    ..Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis...
  35. ncbi Hypoalbuminemia in critically ill children
    Ira N Horowitz
    Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois, USA
    Arch Pediatr Adolesc Med 161:1048-52. 2007
    To evaluate whether hypoalbuminemia on admission is a predictor of adverse outcome in critically ill children.
  36. ncbi Hypoalbuminemia in renal failure: pathogenesis and therapeutic considerations
    C Haller
    Medizinische Klinik I, Hegau Bodensee Klinikum, Singen, Germany
    Kidney Blood Press Res 28:307-10. 2005
    b>Hypoalbuminemia is common in patients with end-stage renal disease (ESRD). It is caused by a combination of a reduced synthesis and an increased degradation of albumin...
  37. ncbi QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia
    Tadanobu Irie
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Int Heart J 51:365-6. 2010
    ..with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia. TDP developed 15 hours after the beginning of a standard infusion of propofol, following the development of ..
  38. pmc Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus
    Chang Seop Lee
    Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Geumam dong, Jeonju 561180, Republic of Korea
    BMC Infect Dis 10:216. 2010
    This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus.
  39. ncbi Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis
    Molly A Bozic
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, IN 46202 5225, USA
    Nutr Clin Pract 25:304-7. 2010
    An 8-year-old patient with cystic fibrosis presented with hypoalbuminemia as the main symptom of severe erosive esophagitis...
  40. ncbi Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients
    Roberto Eljaiek
    Burn Intensive Care Unit, Centre Hospitalier de l Universite de Montreal, Hotel Dieu de Montreal, Faculte de Medecine, Universite de Montreal, Montreal, Canada
    Burns 39:113-8. 2013
    b>Hypoalbuminemia is a common finding in burned patients, but its association with increased morbidity and mortality has not been well established...
  41. pmc Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Prannok Rd, Bangkok Noi, Bangkok 10700, Thailand
    World J Gastroenterol 14:1248-51. 2008
    To determine the relationship between pre-operative hypoalbuminemia and the development of complications following rectal cancer surgery, as well as postoperative bowel function and hospital stay.
  42. ncbi Association of hypoalbuminemia on the first postoperative day and complications following esophagectomy
    Aoife M Ryan
    University Department of Clinical Surgery, Trinity Center for Health Sciences, St James s Hospital, Dublin, Ireland
    J Gastrointest Surg 11:1355-60. 2007
    ..Esophagectomy is associated with a major metabolic stress, and the aim of this study was to determine if the absolute albumin level on the first postoperative day was of value in predicting in-hospital complications...
  43. ncbi Putative role of endothelial lipase in dialysis patients with hypoalbuminemia and inflammation
    Hideki Fujii
    Division of Nephrology, Kidney Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Am J Nephrol 28:974-81. 2008
    ..To clarify the role of EL in dialysis patients, we evaluated serum markers on the basis of the presence of hypoalbuminemia and inflammation.
  44. pmc The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases
    R Al-Shaiba
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:205-7. 2004
    ..001) but not percentage hepatic replacement (P=0.34). These results show that hypoalbuminaemia is associated with the presence of a systemic inflammatory response rather than tumour volume in patients with colorectal liver metastases...
  45. ncbi Aprataxin gene mutations in Tunisian families
    R Amouri
    Institut National de Neurologie, Département de Biologie Moléculaire et de Neuropathologie, CNRS INSERM Universite Louis Pasteur, Illkirch, CHU de Strasbourg, France
    Neurology 63:928-9. 2004
    ..Two novel mutations were identified, the complete deletion of the gene, which seems to not correlate with an increased severity of the disease, and a splice mutation on the acceptor splice site of exon 7...
  46. ncbi Effect of tacrolimus and cyclosporine A on suppression of albumin secretion induced by inflammatory cytokines in cultured human hepatocytes
    Y Li
    Division of Nephrology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    Inflamm Res 55:216-20. 2006
    ..To investigate the effect of tacrolimus (FK506) and cyclosporine A (CSA) on albumin secretion and on the IL-6 -induced suppression of albumin synthesis in cultured human hepatocytes...
  47. ncbi The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients
    Mohammadreza Safavi
    Department of Anesthesiology and Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Ulus Travma Acil Cerrahi Derg 15:120-9. 2009
    The aim of this study was to evaluate the value of hypoalbuminemia or hyperglycemia as predictors for need ventilator and for weaning success in critically ill trauma patients.
  48. ncbi Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer?
    Andrew B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    World J Surg 34:2393-8. 2010
    Studies have indicated that hypoalbuminemia is associated with decreased survival of patients with gastric cancer. However, the prognostic value of albumin may be secondary to an ongoing systemic inflammatory response...
  49. ncbi Ataxia with oculomotor apraxia type 1 in Southern Italy: late onset and variable phenotype
    C Criscuolo
    Department of Neurological Sciences, Federico II University, Naples, Italy
    Neurology 63:2173-5. 2004
    ..A novel homozygous missense mutation (H201Q) was found in one patient and a Japanese missense mutation (P206L) in two. AOA1 clinical heterogeneity and onset later than previously described are shown...
  50. ncbi Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation
    C M Quinzii
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:539-41. 2005
    ..The authors' observations indicate that CoQ10 deficiency may contribute to the pathogenesis of AOA1...
  51. ncbi Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion
    G C Shearer
    Department of Veterans Affairs Northern California Health Care System, Mather, California 95616, USA
    Kidney Int 70:647-53. 2006
    ..The finding that NS serum alters LpL binding to RAEC suggests LpL depletion results from decreased binding rather than defective delivery. This in turn is a consequence of reduced serum albumin or pi but does not require proteinuria...
  52. ncbi Relationship between serum albumin level before initiating haemodialysis and angiographic severity of coronary atherosclerosis in end-stage renal disease patients
    Nobuhiko Joki
    FJSIM, Division of Cardiology and Nephrology, Toho University Ohashi Medical Center, 2 17 6, Ohashi, Tokyo 153 8515, Japan
    Nephrol Dial Transplant 21:1633-9. 2006
    ..The goal of the present study was, in patients with CKD, to clarify the relationship between the angiographic severity of CAD and serum albumin concentration reflecting either inflammation or nutrition or both...
  53. ncbi Serum albumin: relationship to inflammation and nutrition
    Burl R Don
    Division of Nephrology, Department of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Semin Dial 17:432-7. 2004
    b>Hypoalbuminemia is the result of the combined effects of inflammation and inadequate protein and caloric intake in patients with chronic disease such as chronic renal failure...
  54. ncbi Free mycophenolic acid should be monitored in renal transplant recipients with hypoalbuminemia
    Bronwyn A Atcheson
    School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia
    Ther Drug Monit 26:284-6. 2004
    ..Because MPA is highly bound, during hypoalbuminemia the total concentration no longer reflects the free (pharmacologically active) concentration...
  55. ncbi Septic shock secondary to scrub typhus: characteristics and complications
    Lon Chan Thap
    Malaria National Center, Phnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 33:780-6. 2002
    ..and thrombocytopenia; SGOT, ALP, direct bilirubin (DB), total billirubin (TB), BUN, Cr were elevated; hypoalbuminemia was noted. Urinalysis showed that 88.9% of the patients had albuminuria. 77...
  56. ncbi Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children
    Gerhard K Wolf
    Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 7:434-9; quiz 440. 2006
    ....
  57. ncbi Prevalence and significance of hypoalbuminemia in an internal medicine department
    Filippo Numeroso
    Department of Internal Medicine and Biomedical Sciences of University of Parma, Italy, Via Gramsci 14, 43100, Parma, Italy
    Eur J Intern Med 19:587-91. 2008
    ..Yet, no data are available in the literature about the prevalence and clinical significance of hypoalbuminemia in patients hospitalized in an internal medicine ward...
  58. ncbi Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis
    Christopher W Snyder
    Division of Pediatric Surgery, Department of Surgery, University of Alabama, Birmingham, AL 35294 0011, USA
    Pediatr Surg Int 27:1155-8. 2011
    This study attempted to evaluate the association of early hypoalbuminemia with the risk of intestinal failure in gastroschisis patients.
  59. ncbi Hypoalbuminemia 3 months after hospital discharge: significance for long-term survival
    Dennis H Sullivan
    Geriatric Research, Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Am Geriatr Soc 53:1222-6. 2005
    To determine change in albumin from hospital discharge to 3-month follow-up and the prognostic significance of persistent hypoalbuminemia in older veteran patients.
  60. ncbi Hypoalbuminemia and not hyperhomocysteinemia as a risk factor for dementia in hemodialysis patients
    Ying Chih Huang
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung Institute of Technology, Chiayi, Taiwan
    J Ren Nutr 18:347-54. 2008
    ..However, the exact causes of dementia in uremic patients remain unclear. This study attempted to determine which risk factors are associated with dementia in hemodialysis patients...
  61. pmc Digital clubbing in tuberculosis--relationship to HIV infection, extent of disease and hypoalbuminemia
    Henry Ddungu
    Department of Medicine, Makerere University and Mulago Hospital, Kampala, Uganda
    BMC Infect Dis 6:45. 2006
    ..The prevalence of clubbing in patients with pulmonary TB and its association with Human Immunodeficiency Virus (HIV), severity of disease, and nutritional status was assessed...
  62. pmc High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    World J Gastroenterol 11:1356-60. 2005
    In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life...
  63. pmc The relation between hypoalbuminemia and compliance and intima-media thickness of carotid artery in continuous ambulatory peritoneal dialysis patients
    Dong Jin Oh
    Department of Internal Medicine, College of Medicine, Chung Ang University, Seoul, Korea
    J Korean Med Sci 20:70-4. 2005
    ..serum albumin concentration was independently related to the compliance of common carotid artery, suggesting hypoalbuminemia can independently give deleterious effects on the arterial wall in continuous ambulatory peritoneal dialysis ..
  64. ncbi Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies
    Christian J Wiedermann
    Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
    Intensive Care Med 36:1657-65. 2010
    To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI).
  65. ncbi Hyperhomocysteinemia and its relationship to cardiovascular disease in ESRD: influence of hypoalbuminemia, malnutrition, inflammation, and diabetes mellitus
    Mohamed E Suliman
    Division of Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Kidney Dis 41:S89-95. 2003
    ..to CVD in patients with ESRD, and there are strong associations between inflammation, malnutrition, and hypoalbuminemia in these patients...
  66. ncbi The association of anemia and hypoalbuminemia with accelerated decline in GFR among adolescents with chronic kidney disease
    Susan L Furth
    Department of Pediatrics, Johns Hopkins Children s Center, Baltimore, MD, USA
    Pediatr Nephrol 22:265-71. 2007
    ..The adjusted annualized decline in GFR was greater among those with either anemia (hematocrit below 36%), or hypoalbuminemia (albumin below 4 g/dl [40 g/L]). After adjustment, anemia was associated with an accelerated decline of 7...
  67. pmc Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1704-6. 2004
    ..On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25-2.84, P=0.002)...
  68. ncbi Hypoalbuminemia in elderly patients with acute diastolic heart failure
    Stephane Arques
    Department of Cardiology, Aubagne Hospital, France
    J Am Coll Cardiol 42:712-6. 2003
    ....
  69. ncbi Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry
    Bolanle Famakin
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    J Stroke Cerebrovasc Dis 19:17-22. 2010
    ..Additional knowledge about factors that contribute to mortality after stroke is important for instituting therapies to lower mortality. We sought to determine the factors that predict mortality in patients hospitalized for acute stroke...
  70. ncbi Increased albumin plasma efflux contributes to hypoalbuminemia only during early phase of sepsis in rats
    Benoit Ruot
    Centre de Recherche en Nutrition Humaine d Auvergne and Unité de Nutrition et Métabolisme Protéique, Institut National de la Recherche Agronomique Theix, 63 122 Saint Genès Champanelle, France
    Am J Physiol Regul Integr Comp Physiol 284:R707-13. 2003
    The mechanisms leading to hypoalbuminemia in sepsis were explored by measuring plasma volume, albumin distribution, plasma albumin transcapillary escape rate (TER), and efflux (TER x albumin intravascular pool)...
  71. ncbi Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates
    T Dziedzic
    Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Eur J Clin Nutr 61:1318-22. 2007
    b>Hypoalbuminemia in acute stroke patients is associated with increased mortality and morbidity...
  72. ncbi The effect of albumin concentration on plasma sodium and chloride measurements in critically ill patients
    David A Story
    Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
    Anesth Analg 104:893-7. 2007
    ..Further, we proposed that differences between indirect and direct chloride assays might be explained by interference from other plasma constituents, particularly bicarbonate, and possibly albumin...
  73. ncbi Diagnostic discordance for hepatitis C virus infection in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Kidney Dis 46:290-300. 2005
    ....
  74. ncbi Relationship between serum albumin level and aging in community-dwelling self-supported elderly population
    Ikuko Gom
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:37-42. 2007
    ..3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6...
  75. ncbi Low serum albumin levels in patients with paroxysmal atrial fibrillation: what does it mean?
    Yong Ming He
    Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, 215006, P R China
    Acta Cardiol 61:333-7. 2006
    ..Previous studies demonstrated that hypoalbuminaemia significantly correlates with cardiac diseases...
  76. ncbi Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer
    Donald C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Int J Colorectal Dis 22:881-6. 2007
    ..The aim of the study was to examine the value of the combination of an elevated C-reactive protein and hypoalbuminaemia (GPS) in predicting cancer-specific survival after resection for colon and rectal cancer...
  77. ncbi Comparison of the diuretic effect of furosemide mixed with human albumin or fresh frozen plasma for patients with hypoalbuminemia in the intensive care unit
    Chien Wei Hsu
    Intensive Care Unit, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan ROC
    J Nephrol 19:621-7. 2006
    Diuretics are commonly used in the intensive care unit (ICU) for patients with fluid over-loading. Hypoalbuminemia is a major cause of diuretic resistance...
  78. ncbi Comparison of three different methods of evaluation of metabolic acid-base disorders
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 35:1264-70. 2007
    ....
  79. ncbi Effect of hypoalbuminemia on the increased serum cholesteryl ester transfer protein concentration in children with idiopathic nephrotic syndrome
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 40:869-75. 2007
    ..To examine the alteration of cholesteryl ester transfer protein (CETP) mass with the regression of albumin level in childhood nephrotic syndrome (NS) in order to clarify the effect of albumin on CETP in NS...
  80. ncbi A pilot study on tacrolimus treatment in membranous or quiescent lupus nephritis with proteinuria resistant to angiotensin inhibition or blockade
    K C Tse
    Nephrology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Lupus 16:46-51. 2007
    ....
  81. pmc Recently published papers: putting fluids in and taking fluids out
    Catriona J M Shaw
    Department of Nephrology, Worthing General Hospital, Lyndhurst Road, Worthing, West Sussex BN11 2DH, UK
    Crit Care 10:179. 2006
    ..Finally, a large multicentred trial comparing continuous venovenous haemofiltration with intermittent haemodialysis is outlined, the results of which pose more questions than answers...
  82. ncbi Haemoglobin and albumin as markers of HIV disease progression in the highly active antiretroviral therapy era: relationships with gender
    S Shah
    Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School and Royal Free Hospital, Rowland Hill Street, London, UK
    HIV Med 8:38-45. 2007
    ..The aims of the study were to describe gender differences in haemoglobin and albumin and to investigate the prognostic value of these measurements in relation to highly active antiretroviral therapy (HAART)...
  83. ncbi Albumin therapy in clinical practice
    Christian M Mendez
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Nutr Clin Pract 20:314-20. 2005
    ..United States, the indications for which albumin therapy are considered include hypovolemia or shock, burns, hypoalbuminemia, surgery or trauma, cardiopulmonary bypass, acute respiratory distress syndrome, hemodialysis, and ..
  84. ncbi Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis
    Robert J Hoyer
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hematol 82:409-13. 2007
    ..Additional studies are needed to further define the role of bevacizumab in the management of this group of patients...
  85. ncbi Megestrol acetate in a moderate dose for the treatment of malnutrition-inflammation complex in maintenance dialysis patients
    Meenakshi Rammohan
    General Clinical Research Center, Division of Nephrology, Hypertension, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Ren Nutr 15:345-55. 2005
    ..Megestrol acetate, 800 mg/day, has been shown to increase appetite and food intake and to mitigate inflammation in cachectic AIDS and cancer patients, leading to weight gain, but it is also associated with side effects at this dose...
  86. ncbi An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Ren Nutr 15:318-31. 2005
    ..8 g/dL, a marker of malnutrition-inflammation complex syndrome, is observed in approximately half of all maintenance hemodialysis (MHD) patients in the United States and is strongly associated with increased mortality...
  87. doi Albumin administration in the management of neonatal hypoalbuminaemia
    I Morris
    Arch Dis Child Fetal Neonatal Ed 93:F326. 2008
  88. ncbi Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease
    Joseph A Eustace
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Kidney Int 65:1031-40. 2004
    ..Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain...
  89. ncbi Significant association of serum albumin with severity of retinopathy and neuropathy, in addition to that of nephropathy, in Japanese type 2 diabetic patients
    Tomoyuki Iwasaki
    Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
    Endocr J 55:311-6. 2008
    ..The aim of this study was to determine the association between serum albumin and the severity of microvascular complications and presence of coronary artery disease in type 2 diabetic patients...
  90. ncbi Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure
    Berthil H C M T Prinsen
    Department of Vascular Medicine and Metabolism, University Medical Center Utrecht, Utrecht, The Netherlands
    Kidney Int 64:1495-504. 2003
    b>Hypoalbuminemia and hyperfibrinogenemia are frequently observed in patients with chronic renal failure (CRF) and are both associated with cardiovascular diseases...
  91. ncbi Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria
    Zhenmin Ni
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 92868, USA
    Biochim Biophys Acta 1638:129-37. 2003
    ..These observations challenge the conventional view attributing sodium retention in NS to a hypoalbuminemia-induced intravascular volume contraction...
  92. ncbi Hypoalbuminemia is a marker of overhydration in chronic maintenance patients on dialysis
    Francis Dumler
    Division of Nephrology, William Beaumont Hospital, Royal Oak, Michigan 48073 6703, USA
    ASAIO J 49:282-6. 2003
    b>Hypoalbuminemia is an important risk factor for increased morbidity and mortality in patients on dialysis. Hypoalbuminemia is usually attributed to malnutrition or a state of chronic inflammation...
  93. pmc Trends and outcomes associated with serum albumin concentration among incident dialysis patients in the United States
    George A Kaysen
    Division of Nephrology, Department of Medicine and Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California, USA
    J Ren Nutr 18:323-31. 2008
    ..To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004...
  94. pmc Hypoalbuminaemia in critically ill children: incidence, prognosis, and influence on the anion gap
    A Durward
    Paediatric Intensive Care Unit, Guy s Hospital, London, UK
    Arch Dis Child 88:419-22. 2003
    ..We examine this phenomenon in critically ill children, documenting the incidence, early evolution, and prognosis of hypoalbuminaemia (<33 g/l), and quantify its influence on the anion gap...
  95. ncbi Dyslipidemia in pediatric nephrotic syndrome: causes revisited
    Edgard E Delvin
    Department of Clinical Biochemistry, Ste Justine Hospital, University of Montreal, Montreal, Canada
    Clin Biochem 36:95-101. 2003
  96. ncbi [Albumin and its use]
    Dagmara Reingardiene
    Kauno medicinos universiteto Intensyviosios terapijos klinika, Eiveniu 2, 3007 Kaunas
    Medicina (Kaunas) 38:349-52; quiz 353. 2002
    ..There are at the present time no clear indications for A administration. Albumin can be used only as a second-choice infusion solution when other products are not indicated, are contraindicated or have been used up their maximum dose...
  97. ncbi The relationship between serum albumin and hydration status in hemodialysis patients
    Colin H Jones
    Department of Renal Medicine, York District Hospital, York, United Kingdom
    J Ren Nutr 12:209-12. 2002
    A decreased serum albumin level predicts poor survival in end-stage renal failure. Hypoalbuminemia is multifactorial and related to poor nutrition, inflammation, and comorbid disease...
  98. pmc Correction of the anion gap for albumin in order to detect occult tissue anions in shock
    M Hatherill
    Paediatric Intensive Care Unit, School of Child and Adolescent Health, University of Cape Town, and Red Cross War Memorial Childrenrsquo, South Africa
    Arch Dis Child 87:526-9. 2002
    ..It is believed that hypoalbuminaemia confounds interpretation of the anion gap (AG) unless corrected for serum albumin in critically ill children with shock...
  99. ncbi Supplementation with Alfacalcidol increases protein intake and serum albumin concentration in patients undergoing hemodialysis with hpoalbumineamia
    Katsuhiko Yonemura
    Hemodialysis Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Blood Purif 22:210-5. 2004
    We have reported that vitamin D deficiency may be implicated in the pathogenesis of hypoalbuminemia observed in patients with end-stage renal disease, but the mechanism remains to be clarified...
  100. ncbi Nailing the evidence
    Greg S Martin
    Chest 132:2055; author reply 2055-6. 2007
  101. ncbi Evaluation of use of human albumin in critically ill dogs: 73 cases (2003-2006)
    Amy V Trow
    Department of Clinical Sciences, Section of Emergency and Critical Care, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Am Vet Med Assoc 233:607-12. 2008
    ..To evaluate the use of human albumin in critically ill dogs. Design-Retrospective case series...

Research Grants50

  1. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..While hypoalbuminemia is the most powerful predictor of death in ESRD, the cause of hypoalbuminemia in these patients is ..
  2. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..b>Hypoalbuminemia, the strongest predictor of mortality on dialysis, is related to a combination of nutritional, inflammatory ..
  3. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..Nephrotic syndrome (NS) is a kidney disease characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, due to the disruption of renal glomerular filtration barrier (GFB) function...
  4. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2013
    ..Nephrotic syndrome (NS) is a kidney disease characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, due to the disruption of renal glomerular filtration barrier (GFB) function...
  5. Discover and functionally characterize full-penetrance causes of nephrosis/FSGS
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..Nephrotic syndrome (NS) is defined by significant proteinuria, resulting in hypoalbuminemia and edema...
  6. Glucocorticoid Receptor Function in Steroid Resistant Childhood Nephrotic Syndrom
    JORGE A INIGUEZ LLUHI; Fiscal Year: 2010
    Nephrotic Syndrome, characterized by massive proteinuria, hypoalbuminemia and edema, is one of the most frequently seen kidney diseases in children...
  7. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..and clinical features reminiscent of human lupus including proteinuria, red cell casts, renal insufficiency, hypoalbuminemia, thrombocytopenia, alopecia, and seizures...
  8. Chronic Kidney Disease, Vascular Disease and Aging
    Mark J Sarnak; Fiscal Year: 2011
    ..of Diet in Renal Disease (MDRD) Study with the broad aims of evaluating risk factors for kidney failure, hypoalbuminemia and cardiovascular disease at the time of kidney failure, and all cause mortality in 15 years of follow-up...
  9. NC/OFQ analogs as ORL1 agonists to promote gut motility
    MARK FINDEIS; Fiscal Year: 2005
    ..Delay in resuming normal diet is associated with increased catabolism, risk of malnourishment, hypoalbuminemia, and poor healing...
  10. ALCOHOL, NUTRITION, AND IMMUNOMODULATION
    Craig McClain; Fiscal Year: 2000
    ..the metabolic abnormalities/complications of AIDS and ALD including anorexia, cachexia, immune suppression, hypoalbuminemia, increased acute phase reactants and edema, to name only a few...
  11. Nutritional Formulation to Target Muscle Loss in CKD Patients
    Sharon Miller; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hypoalbuminemia and muscle wasting are important predictors of mortality and morbidity in patients with latter stage chronic kidney disease (CKD)...
  12. MODIFICATION OF DIET IN RENAL DISEASE STUDY
    CHARLES TISHER; Fiscal Year: 1993
    ..73 m2. Exclusion criteria include pregnancy, history of poor medical compliance, abnormal body weight, hypoalbuminemia, proteinuria greater than 10 grams/24 hours, uncontrolled hypertension, insulin requiring diabetes mellitus, ..
  13. GENETIC EPIDEMIOLOGY OF IDIOPATHIC NEPHROTIC SYNDROME
    Abhay Vats; Fiscal Year: 2005
    ..from the application) Nephrotic syndrome (NS) is characterized by massive loss of protein in the urine, hypoalbuminemia and generalized swelling...
  14. Impact of Care during CRI on outcomes and cost
    THOMAS CHRISTIAN MIX; Fiscal Year: 2002
    ..The specific aims of this project are: 1) Determine the prevalence and predictors of anemia and hypoalbuminemia among pediatric patients at initiation of dialysis; 2) Determine the clinical outcomes and cost associated ..
  15. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..Because markers of malnutrition-inflammation-cachexia syndrome (MICS) such as hypoalbuminemia of <3...
  16. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  17. PS06-011, HIV Prevention Research with HIV+ Incarcerated Populations
    Frederick Altice; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. Directly Observed Therapy for Community-Released HIV-positive Prisoners
    Frederick Altice; Fiscal Year: 2008
    ..It is therefore likely that the stated aim will be successfully accomplished, despite the challenges of working with prisoners and drug-using populations. [unreadable] [unreadable]..
  19. PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    WILLIAM MITCH; Fiscal Year: 2005
    ..Our results will uncover cellular mechanisms regulating protein turnover in uremia and other catabolic conditions. ..
  20. Molecular Analysis of Ureteric Reflux
    Robert Mak; Fiscal Year: 2006
    ..A clinical database of primary VUR and RN will be set up to establish correlations between biomarkers and phenotype and to test the sensitivity and specificity of these markers for detecting primary VUR and RN. ..
  21. SMAD SIGNALING IN ANGIOTENSIN II-MEDIATED RENAL FIBROSIS
    WILLIAM MITCH; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Improving Health Outcomes for Released HIV+ Prisoners
    Frederick Altice; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. Urinary Biomarkers for Steroid Resistant Nephrotic Syndr
    Robert Mak; Fiscal Year: 2005
    ..We believe that data from the current study will improve our diagnostic and therapeutic strategy and may provide clues to the pathogenetic significance of the identified biomarkers. ..
  24. DIRECTLY OBSERVED ANTI RETROVIRAL THERAPY AMONG ACTIVE D
    Frederick Altice; Fiscal Year: 2004
    ..Secondary measures of interest include quality of life measures, health care utilization and entry into drug treatment. ..
  25. Dietary Protein Requirements in Hemodialysis Patients
    Joel Kopple; Fiscal Year: 2007
    ..Before and after these 5 months, total body protein will be assessed by TBNuf, body cell mass (TBK), and other components of body composition using anthropometry, DXA, and near infra-red interactance. ..
  26. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  27. Predictors of Nephropathy in Type 2 Diabetes
    Julie Lin; Fiscal Year: 2008
    ..D., Ph.D., a leading investigator in the field of nutritional epidemiology. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in renal research. ..
  28. Angiotensin II Receptor Blockade and Chronic Rejection
    Bryan Becker; Fiscal Year: 2003
    ....
  29. Biomarkers in the progression of nephropathy in type 2DM
    Julie Lin; Fiscal Year: 2008
    ..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
  30. "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  31. C/EBP BETA IN HEPATOCYTE GENE EXPRESSION & PROLIFERATION
    Mario Chojkier; Fiscal Year: 2002
    ....
  32. Combination fusion toxin and cytarabine therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2002
    ..We anticipate these studies should provide the basis for the design and implementation of pivotal multi-institutional phase II and III trials of DTGM/cytarabine therapy for relapsed/refractory AML. ..
  33. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  34. HEPATIC FIBROSIS: MOLECULAR MECHANISMS
    Mario Chojkier; Fiscal Year: 2009
    ..The regulation of FLIPL activity by MAPK-RSK-C/EBP( signaling in stellate cells. 2. The role of C/EBP( phosphorylation on stellate cell survival. 3. The modulation of stellate cell survival in C/EBP(Glu217 transgenic mice. ..
  35. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies will hopefully lead to the design of pivotal phase II and III clinical trials which will define the role of DT388IL3 in the management of AML. ..
  36. Clinical Translational Research in Transplant Nephrology
    Bryan Becker; Fiscal Year: 2006
    ..It will also work to meet the NIH's goal of increasing the number of physician-scientists conducting high-quality patient-oriented research. ..
  37. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  38. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  39. RAGE and Glomerulosclerosis
    VIVETTE D AGATI; Fiscal Year: 2007
    ..We propose that identification of RAGE-dependent mechanisms in glomerular diseases may lead to novel therapies to prevent, stabilize or reverse the course of chronic GS. ..
  40. Diphtheria fusion protein therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies should lead to the design of pivotal phase II clinical trials to determine the role of this therapeutic in AML management. ..
  41. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  42. E M Transdifferentiation in Proximal Tubule Cells
    Bryan Becker; Fiscal Year: 2004
    ..abstract_text> ..
  43. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  44. Mechanisms of Hawthorn Action in Heart Failure
    Barry Bleske; Fiscal Year: 2005
    ..The results from this study will have important translation to both the basic and clinical research settings. ..
  45. Estrogen, Inflammation and Cardiovascular Risk
    David Reuben; Fiscal Year: 2003
    ..These findings may provide substantial insight into why CEE appears to promote early but protect against late cardiovascular effects. ..
  46. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  47. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  48. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..