hypoalbuminemia

Summary

Summary: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).

Top Publications

  1. ncbi A new approach to classifying malnutrition in the hemodialysis patient
    Aura O'keefe
    San Diego Dialysis National City, National City, CA, USA
    J Ren Nutr 12:248-55. 2002
  2. ncbi Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD
    Bruce A Cooper
    Department of Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
    Am J Kidney Dis 43:61-6. 2004
  3. ncbi Intravenous albumin administration and body water balance in critically ill patients
    Daniel Ferreira da Cunha
    Nutrition 19:157-8. 2003
  4. ncbi [Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage]
    Ping Xue
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Zhong Xi Yi Jie He Xue Bao 3:443-5. 2005
  5. ncbi Improving albumin levels among hemodialysis patients
    Nathan W Levin
    Am J Kidney Dis 48:171-3. 2006
  6. doi Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: a multi-institutional study
    Derek B Hennessey
    Department of Surgery, Wexford General Hospital, Wexford, Ireland
    Ann Surg 252:325-9. 2010
  7. pmc The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases
    R Al-Shaiba
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:205-7. 2004
  8. ncbi Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy
    Michael Danielski
    Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 42:286-94. 2003
  9. ncbi Hypoalbuminemia is a predictor of delayed postoperative bowel function and poor surgical outcomes in right-sided colon cancer patients
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand
    Asia Pac J Clin Nutr 16:213-7. 2007
  10. ncbi Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 42:256-63. 2003

Detail Information

Publications200 found, 100 shown here

  1. ncbi A new approach to classifying malnutrition in the hemodialysis patient
    Aura O'keefe
    San Diego Dialysis National City, National City, CA, USA
    J Ren Nutr 12:248-55. 2002
    ..As the classification of malnutrition became more definite in the literature, the need to assess the type of malnutrition, thereby the root cause(s) and initiate appropriate intervention(s), has become apparent...
  2. ncbi Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD
    Bruce A Cooper
    Department of Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
    Am J Kidney Dis 43:61-6. 2004
    ..However, previous studies were unable to differentiate between true protein malnutrition and hypoalbuminemia.
  3. ncbi Intravenous albumin administration and body water balance in critically ill patients
    Daniel Ferreira da Cunha
    Nutrition 19:157-8. 2003
  4. ncbi [Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage]
    Ping Xue
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Zhong Xi Yi Jie He Xue Bao 3:443-5. 2005
    ..the occurring mechanism and clinical characteristics of severe acute pancreatitis (SAP) associated with hypoalbuminemia in early stage and its influence on prognosis of SAP and the preventive and therapeutic management of this ..
  5. ncbi Improving albumin levels among hemodialysis patients
    Nathan W Levin
    Am J Kidney Dis 48:171-3. 2006
  6. doi Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: a multi-institutional study
    Derek B Hennessey
    Department of Surgery, Wexford General Hospital, Wexford, Ireland
    Ann Surg 252:325-9. 2010
    ..Surgical site infection (SSI) is an infection occurring in an incisional wound within 30 days of surgery and significantly effects patient recovery and hospital resources...
  7. pmc The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases
    R Al-Shaiba
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:205-7. 2004
    ..001) but not percentage hepatic replacement (P=0.34). These results show that hypoalbuminaemia is associated with the presence of a systemic inflammatory response rather than tumour volume in patients with colorectal liver metastases...
  8. ncbi Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy
    Michael Danielski
    Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 42:286-94. 2003
    b>Hypoalbuminemia is a powerful predictor of cardiovascular mortality in maintenance hemodialysis patients...
  9. ncbi Hypoalbuminemia is a predictor of delayed postoperative bowel function and poor surgical outcomes in right-sided colon cancer patients
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand
    Asia Pac J Clin Nutr 16:213-7. 2007
    ..To determine the relationship between preoperative serum albumin and postoperative bowel function as well as surgical outcomes in right-sided colon cancer patients...
  10. ncbi Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 42:256-63. 2003
    ..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
  11. doi Putative role of endothelial lipase in dialysis patients with hypoalbuminemia and inflammation
    Hideki Fujii
    Division of Nephrology, Kidney Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Am J Nephrol 28:974-81. 2008
    ..To clarify the role of EL in dialysis patients, we evaluated serum markers on the basis of the presence of hypoalbuminemia and inflammation.
  12. doi A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia
    Nada Al Tassan
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Hum Mutat 33:351-4. 2012
    ..Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis...
  13. ncbi Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation
    Kazuhiro Nakamura
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Clin Chim Acta 388:51-8. 2008
    ..The introduction of ATX measurements into clinical laboratory testing is urgently needed...
  14. ncbi QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia
    Tadanobu Irie
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Int Heart J 51:365-6. 2010
    ..with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia. TDP developed 15 hours after the beginning of a standard infusion of propofol, following the development of ..
  15. ncbi Hypoalbuminemia in critically ill children
    Ira N Horowitz
    Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois, USA
    Arch Pediatr Adolesc Med 161:1048-52. 2007
    To evaluate whether hypoalbuminemia on admission is a predictor of adverse outcome in critically ill children.
  16. ncbi Hypoalbuminemia in renal failure: pathogenesis and therapeutic considerations
    C Haller
    Medizinische Klinik I, Hegau Bodensee Klinikum, Singen, Germany
    Kidney Blood Press Res 28:307-10. 2005
    b>Hypoalbuminemia is common in patients with end-stage renal disease (ESRD). It is caused by a combination of a reduced synthesis and an increased degradation of albumin...
  17. doi Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients
    Roberto Eljaiek
    Burn Intensive Care Unit, Centre Hospitalier de l Universite de Montreal, Hotel Dieu de Montreal, Faculte de Medecine, Universite de Montreal, Montreal, Canada
    Burns 39:113-8. 2013
    b>Hypoalbuminemia is a common finding in burned patients, but its association with increased morbidity and mortality has not been well established...
  18. ncbi The association of anemia and hypoalbuminemia with accelerated decline in GFR among adolescents with chronic kidney disease
    Susan L Furth
    Department of Pediatrics, Johns Hopkins Children s Center, Baltimore, MD, USA
    Pediatr Nephrol 22:265-71. 2007
    ..The adjusted annualized decline in GFR was greater among those with either anemia (hematocrit below 36%), or hypoalbuminemia (albumin below 4 g/dl [40 g/L]). After adjustment, anemia was associated with an accelerated decline of 7...
  19. doi Elevated C-reactive protein and hypoalbuminemia measured before resection of colorectal liver metastases predict postoperative survival
    Takashi Kobayashi
    Department of Surgery, Showa General Hospital, Kodaira, Tokyo, Japan
    Dig Surg 27:285-90. 2010
    ..Few studies have investigated whether the Glasgow Prognostic Score (GPS), an inflammation-based prognostic score measured before resection of colorectal liver metastasis (CRLM), can predict postoperative survival...
  20. pmc Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus
    Chang Seop Lee
    Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Geumam dong, Jeonju 561180, Republic of Korea
    BMC Infect Dis 10:216. 2010
    This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus.
  21. ncbi Hypoalbuminemia 3 months after hospital discharge: significance for long-term survival
    Dennis H Sullivan
    Geriatric Research, Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Am Geriatr Soc 53:1222-6. 2005
    To determine change in albumin from hospital discharge to 3-month follow-up and the prognostic significance of persistent hypoalbuminemia in older veteran patients.
  22. doi Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis
    Christopher W Snyder
    Division of Pediatric Surgery, Department of Surgery, University of Alabama, Birmingham, AL 35294 0011, USA
    Pediatr Surg Int 27:1155-8. 2011
    This study attempted to evaluate the association of early hypoalbuminemia with the risk of intestinal failure in gastroschisis patients.
  23. ncbi Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap
    Mark Feldman
    Departments of Internal Medicine and Pathology, Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Lab Clin Med 146:317-20. 2005
    Conflicting data exist as to what extent hypoalbuminemia reduces the anion gap; estimates range from 1.5 to 2.5 mM per g/dL decrease in serum albumin.
  24. pmc Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Prannok Rd, Bangkok Noi, Bangkok 10700, Thailand
    World J Gastroenterol 14:1248-51. 2008
    To determine the relationship between pre-operative hypoalbuminemia and the development of complications following rectal cancer surgery, as well as postoperative bowel function and hospital stay.
  25. pmc Digital clubbing in tuberculosis--relationship to HIV infection, extent of disease and hypoalbuminemia
    Henry Ddungu
    Department of Medicine, Makerere University and Mulago Hospital, Kampala, Uganda
    BMC Infect Dis 6:45. 2006
    ..The prevalence of clubbing in patients with pulmonary TB and its association with Human Immunodeficiency Virus (HIV), severity of disease, and nutritional status was assessed...
  26. doi Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis
    Molly A Bozic
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, IN 46202 5225, USA
    Nutr Clin Pract 25:304-7. 2010
    An 8-year-old patient with cystic fibrosis presented with hypoalbuminemia as the main symptom of severe erosive esophagitis...
  27. ncbi Effect of tacrolimus and cyclosporine A on suppression of albumin secretion induced by inflammatory cytokines in cultured human hepatocytes
    Y Li
    Division of Nephrology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    Inflamm Res 55:216-20. 2006
    ..To investigate the effect of tacrolimus (FK506) and cyclosporine A (CSA) on albumin secretion and on the IL-6 -induced suppression of albumin synthesis in cultured human hepatocytes...
  28. doi Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer?
    Andrew B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    World J Surg 34:2393-8. 2010
    Studies have indicated that hypoalbuminemia is associated with decreased survival of patients with gastric cancer. However, the prognostic value of albumin may be secondary to an ongoing systemic inflammatory response...
  29. ncbi The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients
    Mohammadreza Safavi
    Department of Anesthesiology and Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Ulus Travma Acil Cerrahi Derg 15:120-9. 2009
    The aim of this study was to evaluate the value of hypoalbuminemia or hyperglycemia as predictors for need ventilator and for weaning success in critically ill trauma patients.
  30. ncbi Aprataxin gene mutations in Tunisian families
    R Amouri
    Institut National de Neurologie, Département de Biologie Moléculaire et de Neuropathologie, CNRS INSERM Universite Louis Pasteur, Illkirch, CHU de Strasbourg, France
    Neurology 63:928-9. 2004
    ..Two novel mutations were identified, the complete deletion of the gene, which seems to not correlate with an increased severity of the disease, and a splice mutation on the acceptor splice site of exon 7...
  31. ncbi Ataxia with oculomotor apraxia type 1 in Southern Italy: late onset and variable phenotype
    C Criscuolo
    Department of Neurological Sciences, Federico II University, Naples, Italy
    Neurology 63:2173-5. 2004
    ..A novel homozygous missense mutation (H201Q) was found in one patient and a Japanese missense mutation (P206L) in two. AOA1 clinical heterogeneity and onset later than previously described are shown...
  32. ncbi Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation
    C M Quinzii
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:539-41. 2005
    ..The authors' observations indicate that CoQ10 deficiency may contribute to the pathogenesis of AOA1...
  33. ncbi High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    World J Gastroenterol 11:1356-60. 2005
    In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life...
  34. ncbi Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children
    Gerhard K Wolf
    Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 7:434-9; quiz 440. 2006
    ....
  35. ncbi Septic shock secondary to scrub typhus: characteristics and complications
    Lon Chan Thap
    Malaria National Center, Phnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 33:780-6. 2002
    ..and thrombocytopenia; SGOT, ALP, direct bilirubin (DB), total billirubin (TB), BUN, Cr were elevated; hypoalbuminemia was noted. Urinalysis showed that 88.9% of the patients had albuminuria. 77...
  36. doi Prevalence and significance of hypoalbuminemia in an internal medicine department
    Filippo Numeroso
    Department of Internal Medicine and Biomedical Sciences of University of Parma, Italy, Via Gramsci 14, 43100, Parma, Italy
    Eur J Intern Med 19:587-91. 2008
    ..Yet, no data are available in the literature about the prevalence and clinical significance of hypoalbuminemia in patients hospitalized in an internal medicine ward...
  37. ncbi Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion
    G C Shearer
    Department of Veterans Affairs Northern California Health Care System, Mather, California 95616, USA
    Kidney Int 70:647-53. 2006
    ..The finding that NS serum alters LpL binding to RAEC suggests LpL depletion results from decreased binding rather than defective delivery. This in turn is a consequence of reduced serum albumin or pi but does not require proteinuria...
  38. pmc Serum albumin level correlates with disease severity in patients with Hemorrhagic Fever with Renal Syndrome
    Young Ok Kim
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 18:696-700. 2003
    b>Hypoalbuminemia frequently occurs in Hemorrhagic Fever with Renal Syndrome (HFRS), but clinical significance of hypoalbuminemia is not well known...
  39. ncbi Relationship between serum albumin level before initiating haemodialysis and angiographic severity of coronary atherosclerosis in end-stage renal disease patients
    Nobuhiko Joki
    FJSIM, Division of Cardiology and Nephrology, Toho University Ohashi Medical Center, 2 17 6, Ohashi, Tokyo 153 8515, Japan
    Nephrol Dial Transplant 21:1633-9. 2006
    ..The goal of the present study was, in patients with CKD, to clarify the relationship between the angiographic severity of CAD and serum albumin concentration reflecting either inflammation or nutrition or both...
  40. doi Hypoalbuminemia and not hyperhomocysteinemia as a risk factor for dementia in hemodialysis patients
    Ying Chih Huang
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung Institute of Technology, Chiayi, Taiwan
    J Ren Nutr 18:347-54. 2008
    ..However, the exact causes of dementia in uremic patients remain unclear. This study attempted to determine which risk factors are associated with dementia in hemodialysis patients...
  41. doi Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies
    Christian J Wiedermann
    Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
    Intensive Care Med 36:1657-65. 2010
    To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI).
  42. ncbi Serum albumin: relationship to inflammation and nutrition
    Burl R Don
    Division of Nephrology, Department of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Semin Dial 17:432-7. 2004
    b>Hypoalbuminemia is the result of the combined effects of inflammation and inadequate protein and caloric intake in patients with chronic disease such as chronic renal failure...
  43. ncbi Free mycophenolic acid should be monitored in renal transplant recipients with hypoalbuminemia
    Bronwyn A Atcheson
    School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia
    Ther Drug Monit 26:284-6. 2004
    ..Because MPA is highly bound, during hypoalbuminemia the total concentration no longer reflects the free (pharmacologically active) concentration...
  44. ncbi Score based on hypoalbuminemia and elevated C-reactive protein predicts survival in patients with advanced gastrointestinal cancer
    Maqsood M Elahi
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 48:171-3. 2004
    ..The aim of this study is to assess the value of the combination of hypoalbuminemia and an elevated circulating concentration of C-reactive protein as a prognostic score in patients with ..
  45. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
    To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients.
  46. pmc Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1704-6. 2004
    ..On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25-2.84, P=0.002)...
  47. doi Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy
    Chang Yu Wang
    National Kaohsiung University of Applied Sciences, Taiwan
    Radiother Oncol 92:270-5. 2009
    ..We evaluate if C-reactive protein (CRP) is an objective biomarker of esophageal cancer in patients undergoing radiotherapy...
  48. ncbi Hypoalbuminemia in elderly patients with acute diastolic heart failure
    Stephane Arques
    Department of Cardiology, Aubagne Hospital, France
    J Am Coll Cardiol 42:712-6. 2003
    ....
  49. ncbi Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study
    Marc Jacques Dubois
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:2536-40. 2006
    To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients.
  50. pmc Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 89:1028-30. 2003
    ..001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised...
  51. ncbi Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates
    T Dziedzic
    Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Eur J Clin Nutr 61:1318-22. 2007
    b>Hypoalbuminemia in acute stroke patients is associated with increased mortality and morbidity...
  52. ncbi Association of hypoalbuminemia on the first postoperative day and complications following esophagectomy
    Aoife M Ryan
    University Department of Clinical Surgery, Trinity Center for Health Sciences, St James s Hospital, Dublin, Ireland
    J Gastrointest Surg 11:1355-60. 2007
    ..Esophagectomy is associated with a major metabolic stress, and the aim of this study was to determine if the absolute albumin level on the first postoperative day was of value in predicting in-hospital complications...
  53. doi Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry
    Bolanle Famakin
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    J Stroke Cerebrovasc Dis 19:17-22. 2010
    ..Additional knowledge about factors that contribute to mortality after stroke is important for instituting therapies to lower mortality. We sought to determine the factors that predict mortality in patients hospitalized for acute stroke...
  54. ncbi Increased albumin plasma efflux contributes to hypoalbuminemia only during early phase of sepsis in rats
    Benoit Ruot
    Centre de Recherche en Nutrition Humaine d Auvergne and Unité de Nutrition et Métabolisme Protéique, Institut National de la Recherche Agronomique Theix, 63 122 Saint Genès Champanelle, France
    Am J Physiol Regul Integr Comp Physiol 284:R707-13. 2003
    The mechanisms leading to hypoalbuminemia in sepsis were explored by measuring plasma volume, albumin distribution, plasma albumin transcapillary escape rate (TER), and efflux (TER x albumin intravascular pool)...
  55. ncbi A pilot study on tacrolimus treatment in membranous or quiescent lupus nephritis with proteinuria resistant to angiotensin inhibition or blockade
    K C Tse
    Nephrology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Lupus 16:46-51. 2007
    ....
  56. ncbi Albumin therapy in clinical practice
    Christian M Mendez
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Nutr Clin Pract 20:314-20. 2005
    ..United States, the indications for which albumin therapy are considered include hypovolemia or shock, burns, hypoalbuminemia, surgery or trauma, cardiopulmonary bypass, acute respiratory distress syndrome, hemodialysis, and ..
  57. ncbi The effect of albumin concentration on plasma sodium and chloride measurements in critically ill patients
    David A Story
    Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
    Anesth Analg 104:893-7. 2007
    ..Further, we proposed that differences between indirect and direct chloride assays might be explained by interference from other plasma constituents, particularly bicarbonate, and possibly albumin...
  58. ncbi Diagnostic discordance for hepatitis C virus infection in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Kidney Dis 46:290-300. 2005
    ....
  59. ncbi Megestrol acetate in a moderate dose for the treatment of malnutrition-inflammation complex in maintenance dialysis patients
    Meenakshi Rammohan
    General Clinical Research Center, Division of Nephrology, Hypertension, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Ren Nutr 15:345-55. 2005
    ..Megestrol acetate, 800 mg/day, has been shown to increase appetite and food intake and to mitigate inflammation in cachectic AIDS and cancer patients, leading to weight gain, but it is also associated with side effects at this dose...
  60. ncbi An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Ren Nutr 15:318-31. 2005
    ..8 g/dL, a marker of malnutrition-inflammation complex syndrome, is observed in approximately half of all maintenance hemodialysis (MHD) patients in the United States and is strongly associated with increased mortality...
  61. pmc Recently published papers: putting fluids in and taking fluids out
    Catriona J M Shaw
    Department of Nephrology, Worthing General Hospital, Lyndhurst Road, Worthing, West Sussex BN11 2DH, UK
    Crit Care 10:179. 2006
    ..Finally, a large multicentred trial comparing continuous venovenous haemofiltration with intermittent haemodialysis is outlined, the results of which pose more questions than answers...
  62. ncbi Serum albumin and clinical outcome in pediatric cardiac surgery
    Heitor Pons Leite
    Pediatric Intensive Care Unit and Discipline of Nutrition and Metabolism, Department of Pediatrics, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Nutrition 21:553-8. 2005
    ....
  63. pmc The relation between hypoalbuminemia and compliance and intima-media thickness of carotid artery in continuous ambulatory peritoneal dialysis patients
    Dong Jin Oh
    Department of Internal Medicine, College of Medicine, Chung Ang University, Seoul, Korea
    J Korean Med Sci 20:70-4. 2005
    ..serum albumin concentration was independently related to the compliance of common carotid artery, suggesting hypoalbuminemia can independently give deleterious effects on the arterial wall in continuous ambulatory peritoneal dialysis ..
  64. ncbi Genetical analbuminemia is not an appropriate model for hypoalbuminemia in critically ill patients
    Daniel Chappell
    Chest 132:1717-8; author reply 1718. 2007
  65. ncbi Nailing the evidence
    Greg S Martin
    Chest 132:2055; author reply 2055-6. 2007
  66. ncbi Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer
    Donald C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Int J Colorectal Dis 22:881-6. 2007
    ..The aim of the study was to examine the value of the combination of an elevated C-reactive protein and hypoalbuminaemia (GPS) in predicting cancer-specific survival after resection for colon and rectal cancer...
  67. doi Evaluation of use of human albumin in critically ill dogs: 73 cases (2003-2006)
    Amy V Trow
    Department of Clinical Sciences, Section of Emergency and Critical Care, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Am Vet Med Assoc 233:607-12. 2008
    ..To evaluate the use of human albumin in critically ill dogs. Design-Retrospective case series...
  68. ncbi Comparison of the diuretic effect of furosemide mixed with human albumin or fresh frozen plasma for patients with hypoalbuminemia in the intensive care unit
    Chien Wei Hsu
    Intensive Care Unit, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan ROC
    J Nephrol 19:621-7. 2006
    Diuretics are commonly used in the intensive care unit (ICU) for patients with fluid over-loading. Hypoalbuminemia is a major cause of diuretic resistance...
  69. doi Albumin administration in the management of neonatal hypoalbuminaemia
    I Morris
    Arch Dis Child Fetal Neonatal Ed 93:F326. 2008
  70. ncbi Hypoalbuminemia is an important risk factor of hypotension during hemodialysis
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hemodial Int 10:S10-5. 2006
    ..598, p=0.0016). From these data, we conclude that hypoalbuminemia is a major risk factor of hypotension during HD.
  71. ncbi Haemoglobin and albumin as markers of HIV disease progression in the highly active antiretroviral therapy era: relationships with gender
    S Shah
    Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School and Royal Free Hospital, Rowland Hill Street, London, UK
    HIV Med 8:38-45. 2007
    ..The aims of the study were to describe gender differences in haemoglobin and albumin and to investigate the prognostic value of these measurements in relation to highly active antiretroviral therapy (HAART)...
  72. ncbi Low serum albumin levels in patients with paroxysmal atrial fibrillation: what does it mean?
    Yong Ming He
    Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, 215006, P R China
    Acta Cardiol 61:333-7. 2006
    ..Previous studies demonstrated that hypoalbuminaemia significantly correlates with cardiac diseases...
  73. ncbi Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis
    Robert J Hoyer
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hematol 82:409-13. 2007
    ..Additional studies are needed to further define the role of bevacizumab in the management of this group of patients...
  74. ncbi Comparison of three different methods of evaluation of metabolic acid-base disorders
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 35:1264-70. 2007
    ....
  75. ncbi Alteration of redox state of human serum albumin before and after hemodialysis
    Akinori Soejima
    First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Blood Purif 22:525-9. 2004
    Persistent hypoalbuminemia is a predictor of death in long-term maintenance hemodialysis patients, although cardiovascular diseases remain the leading cause of death...
  76. ncbi Significant association of serum albumin with severity of retinopathy and neuropathy, in addition to that of nephropathy, in Japanese type 2 diabetic patients
    Tomoyuki Iwasaki
    Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
    Endocr J 55:311-6. 2008
    ..The aim of this study was to determine the association between serum albumin and the severity of microvascular complications and presence of coronary artery disease in type 2 diabetic patients...
  77. ncbi Why albumin may still work
    Johan Groeneveld
    Wien Klin Wochenschr 116:283-5. 2004
  78. ncbi The relationship between serum albumin and hydration status in hemodialysis patients
    Colin H Jones
    Department of Renal Medicine, York District Hospital, York, United Kingdom
    J Ren Nutr 12:209-12. 2002
    A decreased serum albumin level predicts poor survival in end-stage renal failure. Hypoalbuminemia is multifactorial and related to poor nutrition, inflammation, and comorbid disease...
  79. ncbi Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease
    Joseph A Eustace
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Kidney Int 65:1031-40. 2004
    ..Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain...
  80. pmc Correction of the anion gap for albumin in order to detect occult tissue anions in shock
    M Hatherill
    Paediatric Intensive Care Unit, School of Child and Adolescent Health, University of Cape Town, and Red Cross War Memorial Childrenrsquo, South Africa
    Arch Dis Child 87:526-9. 2002
    ..Aim: To compare the ability of the AG and the albumin corrected anion gap (CAG) to detect the presence of occult tissue anions...
  81. ncbi Longitudinal and cross-sectional effects of C-reactive protein, equilibrated normalized protein catabolic rate, and serum bicarbonate on creatinine and albumin levels in dialysis patients
    George A Kaysen
    Veterans Affairs Northern California Health Care System, Mather, USA
    Am J Kidney Dis 42:1200-11. 2003
    Loss of muscle mass and hypoalbuminemia each may result in part from either malnutrition, inflammation, or a combination of both. Short-term acidosis increases muscle protein catabolism and inhibits albumin synthesis.
  82. ncbi [Albumin and its use]
    Dagmara Reingardiene
    Kauno medicinos universiteto Intensyviosios terapijos klinika, Eiveniu 2, 3007 Kaunas
    Medicina (Kaunas) 38:349-52; quiz 353. 2002
    ..There are at the present time no clear indications for A administration. Albumin can be used only as a second-choice infusion solution when other products are not indicated, are contraindicated or have been used up their maximum dose...
  83. ncbi Dyslipidemia in pediatric nephrotic syndrome: causes revisited
    Edgard E Delvin
    Department of Clinical Biochemistry, Ste Justine Hospital, University of Montreal, Montreal, Canada
    Clin Biochem 36:95-101. 2003
  84. ncbi Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria
    Zhenmin Ni
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 92868, USA
    Biochim Biophys Acta 1638:129-37. 2003
    ..These observations challenge the conventional view attributing sodium retention in NS to a hypoalbuminemia-induced intravascular volume contraction...
  85. ncbi Supplementation with Alfacalcidol increases protein intake and serum albumin concentration in patients undergoing hemodialysis with hpoalbumineamia
    Katsuhiko Yonemura
    Hemodialysis Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Blood Purif 22:210-5. 2004
    We have reported that vitamin D deficiency may be implicated in the pathogenesis of hypoalbuminemia observed in patients with end-stage renal disease, but the mechanism remains to be clarified...
  86. ncbi Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure
    Berthil H C M T Prinsen
    Department of Vascular Medicine and Metabolism, University Medical Center Utrecht, Utrecht, The Netherlands
    Kidney Int 64:1495-504. 2003
    b>Hypoalbuminemia and hyperfibrinogenemia are frequently observed in patients with chronic renal failure (CRF) and are both associated with cardiovascular diseases...
  87. ncbi Human albumin and starch administration in critically ill patients: a prospective randomized clinical trial
    Thiemo F Veneman
    Department of Internal Medicine, Twenteborg Hospital, Almelo, The Netherlands
    Wien Klin Wochenschr 116:305-9. 2004
    ..e. lower mortality and fewer complications, compared to fluid replacement with normal saline...
  88. pmc Hypoalbuminaemia in critically ill children: incidence, prognosis, and influence on the anion gap
    A Durward
    Paediatric Intensive Care Unit, Guy s Hospital, London, UK
    Arch Dis Child 88:419-22. 2003
    ..We examine this phenomenon in critically ill children, documenting the incidence, early evolution, and prognosis of hypoalbuminaemia (<33 g/l), and quantify its influence on the anion gap...
  89. ncbi Strategies to improve albumin in patients on peritoneal dialysis
    Debra Showers
    Dialysis Clinic, Inc, Columbia, MO, USA
    Nephrol Nurs J 31:592-3. 2004
  90. ncbi Relationship between serum albumin level and aging in community-dwelling self-supported elderly population
    Ikuko Gom
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:37-42. 2007
    ..3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6...
  91. ncbi Serum levels of calcium and albumin in survivors versus nonsurvivors after critical injury
    Roger T Ward
    Department of Surgery, King Drew Medical Center, Los Angeles, CA 90059, USA
    J Crit Care 19:54-64. 2004
    ..Each predictive covariate was ranked, divided into quartiles (grades = normal, mild, moderate, severe), and correlated with patient survival likelihood (viz., ratio of S to N in each quartile)...
  92. ncbi Intestinal protein loss and hypoalbuminemia in children with pneumonia
    Aharon Klar
    Gastroenterology, Bikur Cholim General Hospital, affiliated with the Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Pediatr Gastroenterol Nutr 37:120-3. 2003
    ..Intestinal protein loss during pneumonia with effusion has not been reported to date. The authors attempted to assess the associations between pneumonia with effusion and intestinal protein loss and hypoalbuminemia in children.
  93. ncbi [Clinical and biological aspects of liver damage in infectious mononucleosis]
    Maria Elena Cocuz
    Universitatea Transilvania Braşov
    Bacteriol Virusol Parazitol Epidemiol 48:177-81. 2003
    ..2% of the cases, hypoalbuminemia--82.4% of cases and subunitary albumin/globulin ratio in 70.3% of the cases...
  94. ncbi Albumin turnover: experimental approach and its application in health and renal diseases
    Berthil H C M T Prinsen
    Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, HP KC 02 069 1, Lundlaan 6, Box 85090, 3508 AB Utrecht, The Netherlands
    Clin Chim Acta 347:1-14. 2004
    ..Furthermore, it is involved in mediating blood volume and colloid osmotic pressure (COP). As hypoalbuminemia occurs, as is the case in a number of clinical disorders, adaptation mechanisms may be involved...
  95. ncbi Effect of hypoalbuminemia on the increased serum cholesteryl ester transfer protein concentration in children with idiopathic nephrotic syndrome
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 40:869-75. 2007
    ..To examine the alteration of cholesteryl ester transfer protein (CETP) mass with the regression of albumin level in childhood nephrotic syndrome (NS) in order to clarify the effect of albumin on CETP in NS...
  96. ncbi Hypoalbuminemia is a marker of overhydration in chronic maintenance patients on dialysis
    Francis Dumler
    Division of Nephrology, William Beaumont Hospital, Royal Oak, Michigan 48073 6703, USA
    ASAIO J 49:282-6. 2003
    b>Hypoalbuminemia is an important risk factor for increased morbidity and mortality in patients on dialysis. Hypoalbuminemia is usually attributed to malnutrition or a state of chronic inflammation...
  97. pmc Trends and outcomes associated with serum albumin concentration among incident dialysis patients in the United States
    George A Kaysen
    Division of Nephrology, Department of Medicine and Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California, USA
    J Ren Nutr 18:323-31. 2008
    ..To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004...
  98. ncbi [Clinical studies of pediatric malabsorption syndromes]
    Takashi Hosoyamada
    Department of Pediatrics Fukuoka Red Cross Hospital, Fukuoka, Japan
    Fukuoka Igaku Zasshi 97:322-50. 2006
    ..The major laboratory findings were hypoalbuminemia, decreased immunoglobulin levels and lymphopenia resulting from loss of lymph fluid and protein into the ..
  99. doi Serum trace elements in tube-fed neurological dysphagia patients correlate with nutritional indices but do not correlate with trace element intakes: case of patients receiving enough trace elements intake
    Hitoshi Obara
    Department of Nutrition Management, National Hospital Organization Kamaishi National Hospital, Sadanaicho 4 7 4, Kamaishi, Iwate 026 0053, Japan
    Clin Nutr 27:587-93. 2008
    ..In this study, we aimed to determine nutritional indices that are predictors of serum trace elements in patients with neurological dysphagia on long-term tube feeding...
  100. ncbi [An adult case of visceral leishmaniasis in a province of Black-Sea region, Turkey]
    Nefise Oztoprak
    Zonguldak Karaelmas Universitesi Tip Fakultesi, Enfeksiyon Hastaliklari Anabilim Dali, Zonguldak, Turkiye
    Mikrobiyol Bul 44:671-7. 2010
    ..2°C and hepatosplenomegaly, while laboratory findings yielded anemia, leucopenia, hypoalbuminemia and hypergamaglobulinemia...
  101. ncbi Some aspects of humoral and cellular immunity in naturally occuring feline infectious peritonitis
    S Paltrinieri
    Istituto di Patologia Generale Veterinaria, Milan, Italy
    Vet Immunol Immunopathol 65:205-20. 1998
    ..001). In both effusive and noneffusive forms decreased albumin/globulin ratio (P<0.001) with hypoalbuminemia (P<0.001), hyperglobulinemia (P<0.001) and increased alpha2- (P<0.05), beta- (P<0...

Research Grants93

  1. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..While hypoalbuminemia is the most powerful predictor of death in ESRD, the cause of hypoalbuminemia in these patients is ..
  2. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..b>Hypoalbuminemia, the strongest predictor of mortality on dialysis, is related to a combination of nutritional, inflammatory ..
  3. Chronic Kidney Disease, Vascular Disease and Aging
    Mark Sarnak; Fiscal Year: 2007
    ..of Diet in Renal Disease (MDRD) Study with the broad aims of evaluating risk factors for kidney failure, hypoalbuminemia and cardiovascular disease at the time of kidney failure, and all cause mortality in 15 years of follow-up...
  4. NC/OFQ analogs as ORL1 agonists to promote gut motility
    MARK FINDEIS; Fiscal Year: 2005
    ..Delay in resuming normal diet is associated with increased catabolism, risk of malnourishment, hypoalbuminemia, and poor healing...
  5. GENETIC EPIDEMIOLOGY OF IDIOPATHIC NEPHROTIC SYNDROME
    Abhay Vats; Fiscal Year: 2005
    ..from the application) Nephrotic syndrome (NS) is characterized by massive loss of protein in the urine, hypoalbuminemia and generalized swelling...
  6. Impact of Care during CRI on outcomes and cost
    THOMAS CHRISTIAN MIX; Fiscal Year: 2002
    ..The specific aims of this project are: 1) Determine the prevalence and predictors of anemia and hypoalbuminemia among pediatric patients at initiation of dialysis; 2) Determine the clinical outcomes and cost associated ..
  7. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2009
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  8. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  9. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2007
    ..Because markers of malnutrition-inflammation-cachexia syndrome (MICS) such as hypoalbuminemia of <3...
  10. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2010
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  11. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2009
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  12. Dietary Protein Requirements in Hemodialysis Patients
    Joel Kopple; Fiscal Year: 2007
    ..Before and after these 5 months, total body protein will be assessed by TBNuf, body cell mass (TBK), and other components of body composition using anthropometry, DXA, and near infra-red interactance. ..
  13. PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    WILLIAM MITCH; Fiscal Year: 1993
    ..Na/H antiporter activity will be measured in hepatocytes of CRF rats. Muscle pH in acidotic and CRF rats will be measured by NMR to assess how it varies in comparison to blood pH...
  14. PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    WILLIAM MITCH; Fiscal Year: 2007
    ..The significance of our results is that the two-hit model could apply to many conditions because GC and decreased insulin responses are present in many catabolic illnesses, ..
  15. Mechanisms of Hawthorn Action in Heart Failure
    Barry Bleske; Fiscal Year: 2005
    ..The results from this study will have important translation to both the basic and clinical research settings. ..
  16. UCLA OLDER AMERICANS INDEPENDENCE CENTER
    David Reuben; Fiscal Year: 2007
    ..novel multidisciplinary research 4) To stimulate incorporation of emerging technologies 5) To serve as source of advice and collaboration to other institutions 6) To provide career development of future research leaders ..
  17. MENTORED CLINICAL SCIENTIST DEVELOPMENT PROGRAM
    David Reuben; Fiscal Year: 2007
    ..We also expect the training environment created by the MCSDPA to facilitate independence for junior faculty in aging who do not directly receive MCSDPA support. ..
  18. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  19. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  20. Statins in Non-Ischemic Heart Failure: Potential Mechanisms of Benefit
    Tamara Horwich; Fiscal Year: 2007
    ..This study will investigate how statins may potentially benefit patients with HF, and thus may ultimately contribute to discovering new strategies to treat HF. (End of Abstract) ..
  21. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  22. Molecular Analysis of Ureteric Reflux
    Robert Mak; Fiscal Year: 2006
    ..A clinical database of primary VUR and RN will be set up to establish correlations between biomarkers and phenotype and to test the sensitivity and specificity of these markers for detecting primary VUR and RN. ..
  23. Estrogen, Inflammation and Cardiovascular Risk
    David Reuben; Fiscal Year: 2003
    ..These findings may provide substantial insight into why CEE appears to promote early but protect against late cardiovascular effects. ..
  24. Urinary Biomarkers for Steroid Resistant Nephrotic Syndr
    Robert Mak; Fiscal Year: 2005
    ..We believe that data from the current study will improve our diagnostic and therapeutic strategy and may provide clues to the pathogenetic significance of the identified biomarkers. ..
  25. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2007
    ..abstract_text> ..
  26. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..