pure red cell aplasia

Summary

Summary: Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.

Top Publications

  1. ncbi Immunologic mechanisms of EPO-associated pure red cell aplasia
    Huub Schellekens
    Central Laboratory Animal Institute, Department of Innovation Studies, Utrecht University, P O Box 80 190, 2508 TD Utrecht, Rotterdam, The Netherlands
    Best Pract Res Clin Haematol 18:473-80. 2005
  2. ncbi Thirty-nine cases of pure red cell aplasia: a single center experience from India
    Upendra Srinivas
    Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
    Hematology 12:245-8. 2007
  3. ncbi Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery
    Katia Boven
    Service d Hematologie Biologique, Hopital Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris cedex 4, France
    Nephrol Dial Transplant 20:iii33-40. 2005
  4. doi Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation
    Baijun Fang
    Henan Tumor Hospital, Henan Institute of Haematology, Henan Medical School, Henan University, 127 Dongming Road, Zhengzhou 450008, China
    Ann Hematol 88:261-6. 2009
  5. ncbi Treatment of pure red cell aplasia and autoimmune haemolytic anaemia in chronic lymphocytic leukaemia with Campath-1H
    Philippe Rodon
    Department of Internal Medicine and Haematology, Centre Hospitalier General, Blois, France
    Eur J Haematol 70:319-21. 2003
  6. ncbi Treatment of Epstein-Barr virus--associated lymphoproliferative disorder (EBV-PTLD) and pure red cell aplasia (PRCA) with Rituximab following unrelated cord blood transplantation: a case report and literature review
    Kanger Zhu
    Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
    Hematology 10:365-70. 2005
  7. ncbi Epoetin-induced pure red cell aplasia successfully treated with androgens
    Maria Dolores Sánchez de la Nieta
    Nephrology Unit, Alarcos Hospital, Ciudad Real, Spain
    J Nephrol 19:220-1. 2006
  8. ncbi Histologic types of thymoma associated with pure red cell aplasia: a study of five cases including a composite tumor of organoid thymoma associated with an unusual lipofibroadenoma
    T Kuo
    Department of Pathology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Surg Pathol 9:29-35. 2001
  9. doi Valproate-induced pure red cell aplasia and megakaryocyte dysplasia
    Sandip Bartakke
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Br J Haematol 141:133. 2008
  10. pmc Pure red cell aplasia after 13 years of sodium valproate, and bone marrow suppression after 17 years of carbamazepine
    Tiong The
    Saint Peter s University Hospital, New Brunswick, New Jersey, USA
    PLoS Med 1:e51. 2004

Research Grants

Detail Information

Publications202 found, 100 shown here

  1. ncbi Immunologic mechanisms of EPO-associated pure red cell aplasia
    Huub Schellekens
    Central Laboratory Animal Institute, Department of Innovation Studies, Utrecht University, P O Box 80 190, 2508 TD Utrecht, Rotterdam, The Netherlands
    Best Pract Res Clin Haematol 18:473-80. 2005
    b>Pure red cell aplasia (PRCA) is a relatively rare condition defined as severe anemia secondary to the virtual absence of red cell precursors in the bone marrow...
  2. ncbi Thirty-nine cases of pure red cell aplasia: a single center experience from India
    Upendra Srinivas
    Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
    Hematology 12:245-8. 2007
    b>Pure red cell aplasia (PRCA) is an uncommon disorder, characterized by transfusion dependent anemia, reticulocytopenia with selective aplasia or paucity of erythroid cells in bone marrow...
  3. ncbi Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery
    Katia Boven
    Service d Hematologie Biologique, Hopital Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris cedex 4, France
    Nephrol Dial Transplant 20:iii33-40. 2005
    A substantial increase in the incidence of pure red cell aplasia (PRCA) associated with recombinant human erythropoietin (epoetin) treatment occurred in 1998...
  4. doi Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation
    Baijun Fang
    Henan Tumor Hospital, Henan Institute of Haematology, Henan Medical School, Henan University, 127 Dongming Road, Zhengzhou 450008, China
    Ann Hematol 88:261-6. 2009
    b>Pure red cell aplasia (PRCA) is a well-known, although infrequent, hematological complication after allogeneic hematopoietic stem cell transplantation (HSCT)...
  5. ncbi Treatment of pure red cell aplasia and autoimmune haemolytic anaemia in chronic lymphocytic leukaemia with Campath-1H
    Philippe Rodon
    Department of Internal Medicine and Haematology, Centre Hospitalier General, Blois, France
    Eur J Haematol 70:319-21. 2003
    ..CLL) progressive on fludarabine therapy and life-threatening anaemia related to immune haemolysis and pure red cell aplasia was treated with Campath-1H...
  6. ncbi Treatment of Epstein-Barr virus--associated lymphoproliferative disorder (EBV-PTLD) and pure red cell aplasia (PRCA) with Rituximab following unrelated cord blood transplantation: a case report and literature review
    Kanger Zhu
    Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
    Hematology 10:365-70. 2005
    We report the first case of EBV-PTLD and pure red cell aplasia (PRCA) after an unrelated cord blood transplant in China, who was successfully treated with Rituximab.
  7. ncbi Epoetin-induced pure red cell aplasia successfully treated with androgens
    Maria Dolores Sánchez de la Nieta
    Nephrology Unit, Alarcos Hospital, Ciudad Real, Spain
    J Nephrol 19:220-1. 2006
    b>Pure red cell aplasia (PRCA) is a severe, non-regenerative form of anaemia, with selective erythroid aplasia of the bone marrow...
  8. ncbi Histologic types of thymoma associated with pure red cell aplasia: a study of five cases including a composite tumor of organoid thymoma associated with an unusual lipofibroadenoma
    T Kuo
    Department of Pathology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Surg Pathol 9:29-35. 2001
    The histologic type of thymomas associated with pure red cell aplasia (PRCA) has generally been regarded to be predominantly the spindle cell type...
  9. doi Valproate-induced pure red cell aplasia and megakaryocyte dysplasia
    Sandip Bartakke
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Br J Haematol 141:133. 2008
  10. pmc Pure red cell aplasia after 13 years of sodium valproate, and bone marrow suppression after 17 years of carbamazepine
    Tiong The
    Saint Peter s University Hospital, New Brunswick, New Jersey, USA
    PLoS Med 1:e51. 2004
  11. ncbi [Successful treatment with cyclosporine of sodium valproate-induced pure red cell aplasia]
    Junya Kanda
    The Third Department of Internal Medicine, Osaka Red Cross Hospital
    Rinsho Ketsueki 46:1114-7. 2005
    We report a 67-year-old man who developed pure red cell aplasia (PRCA) during therapy for epilepsy with sodium valproate since April 2004. He was admitted to our hospital because of severe anemia (Hb 5.0g/dl, reticulocyte 0...
  12. pmc Pure red cell aplasia associated with type I autoimmune polyglandular syndrome-successful response to treatment with mycophenolate mofetil: case report and review of literature
    Milena Bakrac
    Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia
    J Clin Pathol 60:717-20. 2007
  13. ncbi Temporary pure red-cell aplasia during valproate monotherapy: clinical observations and spectral electroencephalographic aspects
    V Farkas
    Department of Pediatrics, Semmelweis University, Budapest, Hungary
    J Child Neurol 15:485-7. 2000
    ..After 6 months of phenobarbital therapy, re-administration of sodium valproate was not followed by recurrence of any clinical or electrophysiologic symptoms or abnormalities...
  14. ncbi Recommendations on haematological criteria for the diagnosis of epoetin-induced pure red cell aplasia
    Nicole Casadevall
    Service d Hematologie Biologique, Hopital Hotel Dieu, Paris, France
    Eur J Haematol 73:389-96. 2004
    b>Pure red cell aplasia (PRCA) is a rare condition characterised by an arrest in red blood cell production, which may be congenital or acquired...
  15. doi Rituximab to treat chronic lymphoproliferative disorder-associated pure red cell aplasia
    Giovanni D'Arena
    Hematology and Stem Cell Transplantation Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Eur J Haematol 82:235-9. 2009
    We report four patients (mean age 65 yr; range 40-77 yr) affected by acquired pure red cell aplasia (PRCA) complicating chronic lymphoid disorders and treated with anti-CD20 monoclonal antibody rituximab...
  16. ncbi Clinico-haematological profile of pure red cell aplasia in children
    R K Marwaha
    Division of Pediatric Hematology Oncology, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Trop Pediatr 48:113-6. 2002
    b>Pure red cell aplasia (PRCA) is a rare disorder, characterized by isolated failure of erythropoiesis. The clinico-haematological profile of 16 patients with PRCA is presented in this communication...
  17. ncbi Successful treatment of pure red cell aplasia with a single dose of rituximab in a child after major ABO incompatible peripheral blood allogeneic stem cell transplantation for acquired aplastic anemia
    A A Maschan
    Research Institute for Pediatric Hematology of the Russian Federation, Russian Children s Hospital, Moscow, Russian Federation
    Bone Marrow Transplant 30:405-7. 2002
    b>Pure red cell aplasia (PRCA) is a well-known although infrequent hematologic complication after allogeneic bone marrow transplantation...
  18. ncbi Incidence of recombinant erythropoietin (EPO) hyporesponse, EPO-associated antibodies, and pure red cell aplasia in dialysis patients
    Aantje V Kharagjitsingh
    Department of Internal Medicine, Medical Center Haaglanden, Westeinde, Den Haag, The Netherlands
    Kidney Int 68:1215-22. 2005
    Since 1998, an increase of anti-erythropoietin (anti-EPO) antibody-induced pure red cell aplasia (PRCA) has been reported...
  19. ncbi Antibody-mediated acquired pure red cell aplasia (PRCA) after treatment with darbepoetin
    Rebecca Howman
    Department of Haemotology, Fremantle Hospital, 2 Alma Street, Fremantle, Western Australia 6160
    Nephrol Dial Transplant 22:1462-4. 2007
  20. ncbi [Pure red cell aplasia successfully treated with rituximab in a patient with relapsed diffuse large B-cell lymphoma]
    Takayuki Suzuki
    Department of Hematology, Ohme Municipal General Hospital
    Rinsho Ketsueki 48:67-70. 2007
    ..Here, we describe a 82-year-old woman with pure red cell aplasia (PRCA) complicated with relapsed diffuse large B-cell lymphoma...
  21. ncbi Relapsing pure red cell aplasia associated with B-cell chronic lymphocytic leukemia successfully treated by intravenous immunoglobulin concentrate
    Roberto Castelli
    Servizio di Oncologia Medica, U O di Medicina Interna II, Azienda Ospedaliera G Salvini, Presidio Ospedaliero di Rho, MI
    Ann Ital Med Int 17:47-50. 2002
    b>Pure red cell aplasia (PRCA) is a rare syndrome characterized by a normochromic normocytic anemia and the absence of mature erythroid precursors in an otherwise normocellular bone marrow...
  22. ncbi Response to high-dose dexamethasone for acquired pure red cell aplasia following ABO-mismatched allogeneic stem cell transplantation
    U R Deotare
    Bone Marrow Transplant 37:1149-50. 2006
  23. ncbi The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes
    Katia Boven
    Johnson and Johnson, Pharmaceutical Research and Development, L L C, Raritan, New Jersey, USA
    Kidney Int 67:2346-53. 2005
    The incidence of pure red cell aplasia (PRCA) in chronic kidney disease patients treated with epoetins increased substantially in 1998, was shown to be antibody mediated, and was associated predominantly with subcutaneous administration ..
  24. pmc Acquired pure red cell aplasia: updated review of treatment
    Kenichi Sawada
    Department of Internal Medicine III, Division of Haematology, Akita University Graduate School of Medicine, Akita, Japan
    Br J Haematol 142:505-14. 2008
    b>Pure red cell aplasia (PRCA) is a syndrome characterized by a severe normocytic anaemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow...
  25. ncbi Antibody-mediated pure red cell aplasia in a dialysis patient receiving darbepoetin alfa as the sole erythropoietic agent
    Abraham Jacob
    Department of Haematology and Renal Medicine, Royal Wolverhampton Hospitals, New Cross Hospital, Wolverhampton, West Midlands, WV10 0QP
    Nephrol Dial Transplant 21:2963-5. 2006
  26. doi Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group
    Makoto Hirokawa
    Division of Hematology and Oncology, Department of Medicine, Akita University School of Medicine, Akita, Japan
    Am J Hematol 84:144-8. 2009
    b>Pure red cell aplasia (PRCA) has been reported in association with lymphoma as one of the autoimmune diseases seen during the course of lymphoid malignancies. However, the relation of PRCA with the underlying lymphomas remains unclear...
  27. ncbi Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review
    M H Yang
    Department of Medicine, Taipei Veterans General Hospital, Taiwan
    Ann Hematol 80:299-301. 2001
    b>Pure red cell aplasia (PRCA) is a rare complication after ABO-incompatible allogeneic stem cell transplantation, but its mechanism is still unknown...
  28. doi Diagnosis and management of acquired pure red cell aplasia
    Kenichi Sawada
    Division of Hematology, Department of Medicine, Akita University School of Medicine, Hondo 1 1 1, Akita 018 8543, Japan
    Hematol Oncol Clin North Am 23:249-59. 2009
    b>Pure red cell aplasia is a syndrome characterized by a severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow...
  29. doi The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309
    Kearkiat Praditpornsilpa
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Nephrol Dial Transplant 24:1545-9. 2009
    ..This allele is rare in Caucasian (<1%) but more common in Thai population (8.4-12.5%). This study was aimed to investigate the possible association between HLA-DRB1*09 or other specific HLA and anti-r-HuEpo associated PRCA...
  30. doi Pure red cell aplasia associated with cytomegalovirus infection
    Vishal Kumar
    Department of Pediatrics, Chacha Nehru Bal Chikitsalya, Lady Hardinge Medical College, New Delhi
    J Pediatr Hematol Oncol 32:315-6. 2010
    ..Hemogram and bone marrow aspirate were suggestive of pure red cell aplasia. Serum bilirubin and aminotransferases were elevated...
  31. ncbi Metastatic basal cell carcinoma: complete response to chemotherapy and associated pure red cell aplasia
    Benedito A Carneiro
    Department of Medicine, Evanston Northwestern Healthcare, Illinois, USA
    Cancer Invest 24:396-400. 2006
    ..The patient also developed pure red cell aplasia (PRCA)...
  32. ncbi Autoimmune hemolytic anemias, Evans' syndromes, and pure red cell aplasia in non-Hodgkin lymphomas
    Alexander W Hauswirth
    Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Austria
    Leuk Lymphoma 48:1139-49. 2007
    ..108 cases of non-CLL non-Hodgkin lymphoma (NHL) associated with autoimmune hemolytic anemia (AIHA) (+/- pure red cell aplasia (PRCA)) or Evans' syndrome...
  33. ncbi Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin
    Nicole Casadevall
    Department of Hematology, Hotel Dieu, Paris, France
    N Engl J Med 346:469-75. 2002
    ..We investigated whether there was an immunologic basis for the anemia in these patients...
  34. ncbi Hematide is immunologically distinct from erythropoietin and corrects anemia induced by antierythropoietin antibodies in a rat pure red cell aplasia model
    Kathryn W Woodburn
    Affymax, Inc, Palo Alto, CA 94304, USA
    Exp Hematol 35:1201-8. 2007
    ..peptide-based erythropoiesis-stimulating agent that is in clinical development for the treatment of anemia associated with chronic kidney disease and cancer, to correct antierythropoietin antibody-associated pure red cell aplasia (PRCA).
  35. ncbi Erythropoietic proteins and antibody-mediated pure red cell aplasia: a potential role for micelles
    Huub Schellekens
    Nephrol Dial Transplant 19:2422. 2004
  36. ncbi Pure red cell aplasia associated with parvovirus B19 infection in renal transplantation: the first case report in Mexico
    Luis Jorge Vales-Albertos
    Transplantation 79:739. 2005
  37. doi Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies
    Akinori Hara
    Department of Disease Control and Homeostasis, Graduated School of Medical Science, Kanazawa University, Kanazawa, Japan
    Am J Hematol 83:750-2. 2008
    ..On the basis of these findings, her anemia was diagnosed as the overlap of pure red cell aplasia with autoimmune hemolytic anemia...
  38. pmc Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab
    Elaine M Sloand
    National Heart Lung and Blood Instititute, NIH, Bethesda, MD 20892, USA
    Haematologica 95:382-7. 2010
    b>Pure red cell aplasia and moderate aplastic anemia are marrow failure states with an immune pathogenesis...
  39. pmc Epoetin-associated pure red cell aplasia: past, present, and future considerations
    June M McKoy
    Division of Hematology Oncology and Geriatric Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Transfusion 48:1754-62. 2008
    ..In 1998, epoetin-associated pure red cell aplasia (PRCA) was first reported and causation was attributed to formulations without human serum albumin (HSA), ..
  40. pmc Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project
    Charles L Bennett
    MidWest Center for Health Services Research and Policy Studies, VA Chicago Healthcare System, Chicago, IL, USA
    Blood 106:3343-7. 2005
    ..200 epoetin-treated persons with chronic kidney disease developed antibodies to epoetin, resulting in pure red cell aplasia (PRCA)...
  41. ncbi Eprex-associated pure red cell aplasia and leachates
    Huub Schellekens
    Nat Biotechnol 24:613-4. 2006
  42. ncbi Azathioprine-induced pure red cell aplasia: case report and review
    A Agrawal
    Transplant Unit, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Transplant Proc 36:2689-91. 2004
    ..We report a case of refractory pure red cell aplasia resulting from long-term use of azathioprine in a renal transplant recipient and examine the possible ..
  43. ncbi Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia
    M Zecca
    Pediatric Hematology/Oncology, IRCCS Policlinico San Matteo, University of Pavia, P. le Golgi 2, I-27100 Pavia, Italy
    Blood 97:3995-7. 2001
    Immune-mediated, acquired pure red cell aplasia (PRCA) is a rare disorder frequently associated with other autoimmune phenomena. Conventional immunosuppressive treatment is often unsatisfactory...
  44. doi Successful re-challenge with darbepoetin in a patient with rHu-EPO-induced pure red cell aplasia refractory to immunosuppressive drugs
    Beatrice Viron
    Association pour l Utilisation du Rein Artificiel, France
    Nephrol Dial Transplant 23:2416-8. 2008
  45. ncbi Pure red cell aplasia and myelofibrosis in B-cell neoplasm
    Y Hatta
    Department of Haematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
    J Int Med Res 33:460-6. 2005
    We describe an unusual case of B-cell neoplasm accompanied by pure red cell aplasia (PRCA) and myelofibrosis in a 67-year-old male presenting with severe anaemia...
  46. ncbi Anti-erythropoietin antibodies and pure red cell aplasia
    Jerome Rossert
    Department of Nephrology, Tenon hospital and Pierre and Marie Curie University, Paris, France
    J Am Soc Nephrol 15:398-406. 2004
  47. ncbi Pure red cell aplasia in B-cell lymphoproliferative disorder treated with rituximab: report of two cases and review of the literature
    Kalyani Narra
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Leuk Res 30:109-14. 2006
    b>Pure red cell aplasia (PRCA) is an unusual cause of anemia in patients with chronic lymphoproliferative disorders...
  48. ncbi Antibody-mediated pure red cell aplasia (PRCA) treatment and re-treatment: multiple options
    Jerome Rossert
    Department of Nephrology, Georges Pompidou European Hospital AP HP, 20 rue Leblanc, 75015 Paris, France
    Nephrol Dial Transplant 20:iv23-26. 2005
    In the vast majority of patients with antibody (Ab)-mediated pure red cell aplasia (PRCA), simple withdrawal of the erythropoiesis-stimulating agent (ESA) does not effectively reverse PRCA...
  49. ncbi Rapid resolution of EPO-induced pure red cell aplasia after a course of immunoadsorption therapy using protein A columns
    Per Westerlund
    Department of Medicine, Blekinge Hospital, Karlshamn, Sweden
    Am J Kidney Dis 45:e97-9. 2005
    b>Pure red cell aplasia (PRCA) is a rare, but important, complication of erythropoietin (EPO) replacement therapy in patients with renal disease...
  50. ncbi Anti-CD20 monoclonal antibody rituximab for the treatment of B-cell chronic lymphocytic leukemia-associated pure red cell aplasia
    Despina Pantelidou
    Hematol J 5:546-7. 2004
  51. ncbi Antibody-mediated pure red cell aplasia (PRCA): epidemiology, immunogenicity and risks
    Iain C Macdougall
    King s College Hospital, Renal Unit, East Dulwich Grove, London SE5 9RS, UK
    Nephrol Dial Transplant 20:iv9-15. 2005
    Although epoetin-induced antibody (Ab)-mediated pure red cell aplasia (PRCA) was very rare prior to 1998, a large increase in the number of global cases was observed from 1999 to 2002 in patients treated with erythropoiesis-stimulating ..
  52. ncbi Treatment of erythropoietin-induced pure red cell aplasia: a retrospective study
    David Verhelst
    Department of Nephrology, Tenon Hospital, Assistance Publique Hopitaux de Paris, and Pierre and Marie Curie University, Paris, France
    Lancet 363:1768-71. 2004
    ..kidney disease treated in this way have developed neutralising antibodies to erythropoietin, causing pure red cell aplasia. We aimed to collate clinical and pathological features in patients unequivocally shown to have ..
  53. ncbi Epoetin-induced autoimmune pure red cell aplasia
    Nicole Casadevall
    Department of Hematology, Hotel Dieu and INSERM U362, Paris, France
    J Am Soc Nephrol 16:S67-9. 2005
    ..10 yr of therapy with recombinant human erythropoietin ([EPO]), only three cases of antibody-associated pure red cell aplasia have been described in patients who were treated with EPO, whereas several millions of patients have ..
  54. ncbi Re-challenging patients who developed pure red cell aplasia with epoetin: can it be done?
    Iain C Macdougall
    Department of Renal Medicine, King s College Hospital, London, UK
    Nephrol Dial Transplant 19:2901-5. 2004
  55. ncbi Antibody-mediated pure red cell aplasia due to epoetin alfa during antiviral therapy of chronic hepatitis C
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology and the Division of Hematology Oncology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Am J Gastroenterol 100:1415-9. 2005
    ..Increasingly, epoetin alfa is used to prevent anemia in this setting. Below, we report the first case of pure red cell aplasia (PRCA) in a patient with chronic hepatitis C who received epoetin alfa (Procrit) to manage anti-viral ..
  56. ncbi Persistence of parvovirus B19 IgM antibodies and DNA in pure red cell aplasia resulting in myelodysplasia--a case report
    J Kishore
    Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
    Indian J Pathol Microbiol 47:78-81. 2004
    ..We report here for the first time from Inida a case of pure red cell aplasia in a 45-year-old female for last 7 years due to chronic persistent B19 infection leading to myelodysplasia ..
  57. ncbi Anti-erythropoietin antibody-mediated pure red cell aplasia after treatment with recombinant erythropoietin products: recommendations for minimization of risk
    Denis Cournoyer
    Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Am Soc Nephrol 15:2728-34. 2004
    Since 1998, there has been a marked increase in incidence of pure red cell aplasia secondary to development of anti-erythropoietin antibodies (Ab+ PRCA) in patients who have chronic kidney disease (CKD) and receive recombinant ..
  58. ncbi Pure red cell aplasia secondary to epoetin alpha responding to Darbepoetin alpha in a patient on peritoneal dialysis
    Ashwin Asari
    Manchester Royal Infirmary, England
    J Am Soc Nephrol 15:2204-7. 2004
    ..He initially responded well to Epoetin alpha (Eprex) but subsequently developed EPO antibodies and pure red cell aplasia (PRCA), becoming blood transfusion dependent...
  59. ncbi Prolonged course of pure red cell aplasia after erythropoietin therapy
    L Nigg
    Renal Division, Department of Medicine, University Hospital, Zurich, Switzerland
    Eur J Haematol 73:376-9. 2004
    b>Pure red cell aplasia (PRCA) caused by neutralising anti-erythropoietin antibodies is a very rare disease...
  60. ncbi Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia
    Marcora Mandreoli
    Department of Nephrology and Dialysis, Policlinico S Orsola, Malpighi, Bologna, Italy
    Am J Kidney Dis 44:757-61. 2004
    An 80-year-old man with chronic renal failure (CRF) had pure red cell aplasia (PRCA) 9 months after starting the subcutaneous administration of recombinant human erythropoietin alfa (rHuEPO-alpha)...
  61. ncbi Pure red cell aplasia associated with thymoma: clinical insights from a 50-year single-institution experience
    Carrie A Thompson
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Br J Haematol 135:405-7. 2006
    Acquired pure red cell aplasia (PRCA) is a rare disorder of erythropoiesis that can develop in association with a thymoma...
  62. ncbi Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Neurol Neurosurg 106:16-8. 2003
    b>Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA...
  63. ncbi Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia
    Hassan Ghazal
    Kentucky Cancer Clinic, 200 Medical Center Dr, Suite 3 0, Hazard, KY 41701, USA
    Blood 99:1092-4. 2002
    b>Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow...
  64. ncbi Allergic skin and systemic reactions in a patient with pure red cell aplasia and anti-erythropoietin antibodies challenged with different epoetins
    Gertrud Weber
    Department of NephrologyAlfried Krupp Hospital, Essen, Germany
    J Am Soc Nephrol 13:2381-3. 2002
    ..who developed wheals at the sites of subcutaneous injections of epoetin-alpha before the manifestation of pure red cell aplasia (PRCA)...
  65. ncbi Pure red cell aplasia preceding malignant lymphoma in a renal transplant patient
    A A Kiykim
    Hacettepe University, Faculty of Medicine, Nephrology Unit, Ankara, Turkey
    Nephron 92:232-4. 2002
    ..We present herein a renal transplant recipient with malignant lymphoma which preceded by pure red cell aplasia (PRCA). Acquired PRCA is a rare hematologic disorder in renal transplant recipients...
  66. pmc Persistent anemia in a patient with diffuse large B cell lymphoma: pure red cell aplasia associated with latent Epstein-Barr virus infection in bone marrow
    Hwa Jung Sung
    Division of Hematology and Oncology, Department of Internal Medicine, Korea University Medical Center, Seoul, Korea
    J Korean Med Sci 22:S167-70. 2007
    We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma...
  67. ncbi Acute viral hepatitis A and parvovirus B19 infections complicated by pure red cell aplasia and autoimmune hemolytic anemia
    Aref Chehal
    J Hepatol 37:163-5. 2002
  68. doi Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group
    Makoto Hirokawa
    Division of Hematology and Oncology, Department of Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Haematologica 93:27-33. 2008
    Thymoma-associated pure red cell aplasia (PRCA) accounts for a significant proportion of cases of secondary PRCA and immunosuppressive therapy has been reported to be useful in this condition...
  69. doi Pure red cell aplasia induced by erythropoiesis-stimulating agents
    Carol Pollock
    Department of Medicine, Royal North Shore Hospital, University of Sydney, Department of Medicine, Pacific Highway, Street Leonards, NSW, 2065, Australia
    Clin J Am Soc Nephrol 3:193-9. 2008
    b>Pure red cell aplasia in patients who are treated for anemia of chronic kidney disease with erythropoiesis-stimulating agents such as epoetin was first reported in 1998...
  70. ncbi Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia
    Shaun A Summers
    Renal Medicine, Southend General Hospital, Westcliff on Sea, Essex, UK
    Nephrol Dial Transplant 19:2137-9. 2004
  71. ncbi Remarkable response to rituximab in a 72-year-old patient with refractory non-Hodgkin's lymphoma and marrow aplasia
    G Egerer
    Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Hospitalstr. 3, 69115 Heidelberg, Germany
    Leuk Lymphoma 42:551-3. 2001
    ..We observed a continuous complete remission induced by rituximab alone in a 72 year old patients with refractory and progressive high-grade non-Hodgkin's lymphoma (NHL) in the phase of chemotherapy induced marrow aplasia...
  72. ncbi Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia
    H Katayama
    Department of Internal Medicine, National Sanatrium Minami Okayama Hospital, 4066 Hayashima Cho, Tsukubo Gun, Okayama 701-0304, Japan
    Leuk Lymphoma 42:539-42. 2001
    ..Co-existing autoimmune haemolytic anemia (AIHA) and pure red cell aplasia (PRCA) were diagnosed...
  73. ncbi Concomitant thymectomy and cardiac operation in a patient with pure red cell aplasia
    M Poullis
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, England
    Ann Thorac Surg 72:621-3. 2001
    b>Pure red cell aplasia is a rare condition resulting in severe anemia. Medical therapy is indicated, unless a thymoma is present...
  74. ncbi Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes
    R S Go
    Divisions of Hematology and Hematopathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Blood 98:483-5. 2001
    Acquired pure red cell aplasia (PRCA) can be associated with lymphoproliferative disease of granular T lymphocytes (T-LDGL), also known as T-cell large granular lymphocyte leukemia...
  75. ncbi Pure red cell aplasia due to parvovirus B19 in a patient treated with rituximab
    V R Sharma
    Division of Medical Oncology Hematology, The Department of Pathology, and the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 96:1184-6. 2000
    ..The reported case depicts a serious consequence of this effect of rituximab therapy: pure red cell aplasia resulting from chronic parvovirus B19 infection...
  76. ncbi Persistent parvovirus B19 related anemia of seven years' duration in an HIV-infected patient: complete remission associated with highly active antiretroviral therapy
    E Mylonakis
    Department of Medicine, The Miriam Hospital, Brown University School of Medicine, Providence, Rhode Island 02906, USA
    Am J Hematol 60:164-6. 1999
    ..Aggressive antiretroviral treatment may effectively diminish transfusion requirements among HIV-infected individuals with pure RBC aplasia resulting from parvovirus B19 infection...
  77. ncbi Pure red cell aplasia and myasthenia gravis with thymoma: a case report and review of the literature
    S Mizobuchi
    Department of Surgery II, Kochi Medical School, Japan
    Jpn J Clin Oncol 28:696-701. 1998
    A case of pure red cell aplasia (PRCA), myasthenia gravis (MG) and thymoma is reported. A 70-year-old woman presented with severe anemia...
  78. ncbi Pure red cell aplasia due to parvovirus B19 infection in a man with HIV infection
    J A de Mayolo
    Department of Medicine, University of Miami School of Medicine, FL 33136
    South Med J 83:1480-1. 1990
    ..Parvovirus should be added to the list of pathogens that can complicate the course of HIV infection and should be considered in the evaluation of severe anemia or red cell aplasia in any immunocompromised patient...
  79. ncbi Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS
    N Frickhofen
    National Heart, Lung, and Blood Institute, Bethesda, Maryland
    Ann Intern Med 113:926-33. 1990
    ..To determine the role of B19 parvovirus in red cell aplasia of patients infected with human immunodeficiency virus type 1 (HIV-1)...
  80. ncbi Successful response to rituximab in a patient with pure red cell aplasia complicating chronic lymphocytic leukaemia
    Montserrat Batlle
    Br J Haematol 118:1192-3. 2002
  81. ncbi Lesson learned from Eprex-associated pure red cell aplasia
    Huub Schellekens
    Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Kidney Blood Press Res 30:9-12. 2007
  82. ncbi Thymoma with paraneoplastic syndromes, Good's syndrome, and pure red cell aplasia
    Jacolien van der Marel
    HagaHospital, Department of Surgery, The Hague, The Netherlands
    J Thorac Oncol 2:325-6. 2007
  83. ncbi Successful treatment of refractory pure red cell aplasia associated with lymphoproliferative disorders with the anti-CD52 monoclonal antibody alemtuzumab (Campath-1H)
    Xiuqing Ru
    Division of Hematology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Br J Haematol 123:278-81. 2003
    Acquired pure red cell aplasia (PRCA) is a rare, but significant, complication of lymphoproliferative disorders...
  84. ncbi Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection
    Masanori Daibata
    Third Department of Internal Medicine, Kochi Medical School, Kochi, Japan
    Int J Hematol 77:354-8. 2003
    We describe a woman with a congenital chromosome anomaly, 47,XXX, who developed chronic pure red cell aplasia (PRCA)...
  85. ncbi Lamivudine-induced pure red cell aplasia
    A Majluf-Cruz
    Unidad de Investigacion en Epidemiologia Clinica, Hospital General Regional Gabriel Mancera, Mexico City, Mexico
    Am J Hematol 65:189-91. 2000
    The aim of this report is to describe five patients with lamivudine-induced pure red cell aplasia, an association not previously described...
  86. ncbi Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology
    M Dungarwalla
    Department of Haematology, St George s Hospital, Tooting, London, UK
    Ann Hematol 86:191-7. 2007
    ..Six patients had autoimmune neutropenia (AIN), two had pure red cell aplasia (PRCA), one had AIN and autoimmune haemolytic anaemia, one had AIN and immune thrombocytopaenia purpura (..
  87. ncbi Aplastic anemia and pure red cell aplasia associated with large granular lymphocyte leukemia
    Ronald S Go
    Gundersen Lutheran Medical Center, La Crosse, WI, USA
    Semin Hematol 40:196-200. 2003
    Aplastic anemia (AA) and pure red cell aplasia (PRCA) are two of the various types of immune-mediated cytopenias that can be associated with large granular lymphocyte (LGL) leukemia...
  88. ncbi Pure red cell aplasia--a rare disease with multiple causes
    M Djaldetti
    Research Laboratory Unit, Rabin Medical Center, Golda Campus, 7, Keren Kayemet Street, Petah Tiqva, The Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Biomed Pharmacother 57:326-32. 2003
    b>Pure red cell aplasia (PRCA) is a relatively rare disease although multiple factors are implied in the pathogenesis of its development...
  89. ncbi Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group
    Ken ichi Sawada
    Division of Haematologyand Oncology, Department of Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan u ac jp
    Haematologica 92:1021-8. 2007
    Cyclosporine A (CsA) has become one of the leading agents for the treatment of pure red cell aplasia (PRCA)...
  90. ncbi Pure red-cell aplasia due to parvovirus B19 infection in a patient treated with alemtuzumab
    Kirsten E Herbert
    Blood 101:1654. 2003
  91. ncbi A case of pure red cell aplasia complicated by Evans syndrome
    Yasuhiko Toyokawa
    Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Mod Rheumatol 17:333-7. 2007
    ..She was diagnosed with pure red cell aplasia (PRCA) associated with Evans syndrome...
  92. ncbi Prevalence of anti-erythropoietin antibodies in hemodialysis patients without clinical signs of pure red cell aplasia. Comparison between hypo- and normoresponsive patients treated with epoetins for renal anemia
    Markus P Stoffel
    Department of Internal Medicine, Division of Nephrology, University Hospital of Cologne, Cologne, Germany
    Nephron Clin Pract 105:c90-8. 2007
    The prevalence of anti-erythropoietin antibodies in renal patients without clinical evidence of pure red cell aplasia (PRCA) who respond poorly to epoetin is unknown...
  93. ncbi [Diagnosis and treatment of pure red-cell aplasia induced by erythropoiesis stimulating agents]
    Jerome Rossert
    AP HP HEGP, Universite Paris Descartes, INSERM U652, Paris, France
    Nephrol Ther 2:S283-6. 2006
    ..Isolated case reports suggest that, at least in some patients, treatments with ESA can be resumed after recovery from antibody-mediated pure red-cell aplasia...
  94. ncbi Response to cyclosporine A in a patient with pure red cell aplasia due to antierythropoietin-alpha antibodies
    Mony Fraer
    Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, USA
    Semin Dial 19:251-4. 2006
    Reported cases of pure red cell aplasia (PRCA) from the administration of erythropoietin (EPO)-alpha molecule in the United States are rare, and the optimal treatment is still unknown...
  95. ncbi Anemia and erythropoietin treatment in chronic kidney diseases
    A Santoro
    Unit of Nephrology and Dialysis, Policlinico S Orsola Malpighi, Bologna, Italy
    Minerva Urol Nefrol 57:23-31. 2005
    ..The hemoglobin concentration target in pre-dialysis and dialysis patients is the subject of continuous re-assessment...
  96. ncbi Parvovirus B19-induced anemia in renal transplantation: a role for rHuEPO in resistance to classical treatment
    Nadia Arzouk
    Nephrology Unit, Bicetre Hospital, Le Kremlin Bicetre France
    Transpl Int 19:166-9. 2006
    Human parvovirus B19 (PVB 19) is responsible for pure red cell aplasia in immunocompromised patients, and particularly solid organ recipients...
  97. ncbi Pure red cell aplasia followed by disseminated intravascular coagulation in a haemodialysis patient receiving erythropoietin-beta
    Lucio Manenti
    Division of Nephrology and Dialysis, Desenzano del Garda Hospital, and Department of Clinical Medicine, Nephrology and Health Science, University of Parma, Italy
    Nephrol Dial Transplant 22:1465-7. 2007
  98. ncbi Erythropoietin-induced, antibody-mediated pure red cell aplasia
    Jerome Rossert
    Hopital Europeen Georges Pompidou, Paris, France
    Eur J Clin Invest 35:95-9. 2005
    b>Pure red cell aplasia (PRCA) is a rare haematological condition that is characterized by severe aregenerative anaemia due to an almost complete cessation of red blood cell production...
  99. ncbi Adverse event issue management: what have we learnt from pure red cell aplasia (PRCA)?
    Iain C Macdougall
    Renal Unit, King s College Hospital, East Dulwich Grove, London SE22 8PT, UK
    Nephrol Dial Transplant 20:viii18-21. 2005
    After 1998, the number of reported cases of pure red cell aplasia (PRCA) increased dramatically among patients with chronic renal failure treated with exogenous erythropoietin, although the incidence of this condition has now abated...
  100. ncbi Anti-erythropoietin antibody-mediated pure red cell aplasia in a living donor liver transplant recipient treated for hepatitis C virus
    Jordan M Schecter
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Liver Transpl 13:1589-92. 2007
    ..We present the first reported case of anti-erythropoietin antibody-mediated pure red cell aplasia arising in the setting of hepatitis C virus therapy in a patient who underwent living donor liver ..
  101. ncbi Antibody-mediated pure red-cell aplasia (PRCA): the Spanish experience
    J Carracedo
    Renal Unit, University Hospital Reina Sofia, Cordoba Spain
    J Nephrol 18:382-7. 2005
    ..Although most PRCA cases have occurred in Europe, the varying epidemiologies among individual countries have not been well characterized...

Research Grants50

  1. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2010
    ..sickle-cell disease, thalassemia major (Cooley's anemia), Diamond-Blackfan anemia, aplastic anemia, pure red cell aplasia, hypoplastic and myelodysplastic disorders...
  2. Feline Leukemia Virus C Receptor Heme Export and Erythroid Differentiation
    Sioban Keel; Fiscal Year: 2007
    ..Cats naturally or experimentally infected with feline leukemia virus, subgroup C (FeLV-C) develop profound pure red cell aplasia (PRCA) or on rare occasion ineffective erythropoiesis...
  3. FELINE LEUKEMIA VIRUS-INDUCED HEMATOLOGIC DISEASE
    JANIS ABKOWITZ; Fiscal Year: 1991
    ..Further studies are outlined to define the mechanisms underlying pure red cell aplasia (PRCA) in cats infected with FeLV-C/Sarma...
  4. Physiology of feline leukemia virus C receptor, FLVCR
    JANIS ABKOWITZ; Fiscal Year: 2009
    Feline leukemia virus, subgroup C (FeLV-C) induces pure red cell aplasia (PRCA) in viremic cats. There is an absence of erythroid precursors, reticulocytopenia, and severe anemia...
  5. Bone Marrow Failure Clinical Research Center
    Jaroslaw Maciejewski; Fiscal Year: 2006
    ..nocturnal hemoglobinuria, single-lineage cytopenias including large granular lymphocyte leukemia and pure red cell aplasia, and various myelodysplastic syndromes...
  6. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2007
    ..4. characterize the phenotype of mice hemizygous for LAMR1 including hematological analysis, cancer incidence, and the presence of other congenital abnormalities. ..
  7. FELINE LEUKEMIA VIRUS INDUCED RED CELL APLASIA
    JANIS ABKOWITZ; Fiscal Year: 2003
    Cats viremic with feline leukemia virus, subgroup C (FeLV-C) develop pure red cell aplasia (PRCA). This results from a block in BFU-E to CFU-E maturation...
  8. Molecular Pathogenesis of Diamond Blackfan Anemia
    KATHLEEN MIHO contact SAKAMOTO; Fiscal Year: 2010
    Diamond Blackfan Anemia (DBA) is a heterogeneous disease in which patients present with pure red cell aplasia, congenital abnormalities, and an increased risk of cancer...
  9. A Vital Tool for the Study of DBA:The Diamond Blackfan Anemia Registry
    Jeffrey M Lipton; Fiscal Year: 2010
    ..DBA is a heterogeneous genetic disorder characterized by pure red cell aplasia, congenital anomalies and a predisposition to cancer...
  10. Chicago Cancer Navigation Project
    Charles Bennett; Fiscal Year: 2007
    ..abstract_text> ..
  11. Chicago Cancer Navigation Project
    Charles Bennett; Fiscal Year: 2007
    ..follow-up diagnostic evaluations to improve mean time to a diagnostic resolution between abnormal screening and definitive follow-up for the intervention sites as compared to both previous performance and to the usual care control sites ..
  12. The DBA Registry: A Vital Tool for the Study of DBA
    Jeffrey Lipton; Fiscal Year: 2007
    ..marrow failure syndrome Diamond Blackfan anemia (DBA), a heterogeneous genetic disorder characterized by pure red cell aplasia, congenital anomalies and a predisposition to cancer...
  13. Research on Adverse Drug Events and Reports: Novel Multiple Myeloma Drugs
    Charles Bennett; Fiscal Year: 2007
    ....
  14. Intervention for Colorectal Cancer
    Charles Bennett; Fiscal Year: 2003
    ..The proposed interventions will improve the standard Veterans Affairs colorectal cancer screening protocol and will provide a model for methods and materials to increase screening rates in other settings. ..
  15. Demonstration Project: State-Based Screening for Chronic Kidney Disease
    Allan Collins; Fiscal Year: 2007
    ..The screening system proposed in this application addresses the public-health need to target high-risk individuals in order to improve prevention and control of CKD and reduce the cost of its treatment. ..
  16. THE ROLE OF DENDRITIC CELLS IN IMMUNITY TO FIV INFECTION
    WENDY SPRAGUE; Fiscal Year: 2005
    ..Results of these DC-based vaccine studies will provide useful proof-of-principle information regarding the induction of protective immunity immunodeficiency virus infections. ..
  17. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ....
  18. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo Lara; Fiscal Year: 2009
    ....
  19. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo Lara; Fiscal Year: 2007
    ....