hypochromic anemia

Summary

Summary: Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

Top Publications

  1. ncbi alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia
    Masoud Garshasbi
    Haematologica 88:1196-7. 2003
  2. ncbi Sex-linked anemia: a hypochromic anemia of mice
    R M Bannerman
    Science 151:581-2. 1966
  3. ncbi Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats
    Sayuri Kojima
    The Institute of Environmental Toxicology, Joso shi, Ibaraki, Japan
    J Toxicol Sci 34:527-39. 2009
  4. ncbi Genotyping of alpha-thalassemia in microcytic hypochromic anemia patients from North India
    Vaikam H Sankar
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Appl Genet 47:391-5. 2006
  5. ncbi A mutation in the gene for delta-aminolevulinic acid dehydratase (ALAD) causes hypochromic anemia in the medaka, Oryzias latipes
    Daigo Sakamoto
    Department of Biological Information, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Mech Dev 121:747-52. 2004
  6. ncbi Microcytic hypochromic anemia patients with thalassemia: genotyping approach
    Fakher Rahim
    Research Center of Thalassemia and Hemoglobinopathies, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran
    Indian J Med Sci 63:101-8. 2009
  7. ncbi A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma
    Tomoko Akase
    Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
    Yakugaku Zasshi 123:817-24. 2003
  8. ncbi Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
    Said Lyoumi
    INSERM U773, Paris, France
    Blood 109:811-8. 2007
  9. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008
  10. doi Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia
    Roosy Aulakh
    Department of Pediatrics, Christian Medical College and Hospital, Ludhiana, Punjab, India
    Indian J Pediatr 76:265-8. 2009

Detail Information

Publications187 found, 100 shown here

  1. ncbi alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia
    Masoud Garshasbi
    Haematologica 88:1196-7. 2003
    ..Five different mutations (-alpha(3.7), -alpha(4.2), --MED, -(alpha)20.5, Hb Constant Spring) were identified in a total of 43 cases..
  2. ncbi Sex-linked anemia: a hypochromic anemia of mice
    R M Bannerman
    Science 151:581-2. 1966
    ..Though the anemia occurs on a normal diet, it responds rapidly to iron-dextran injection. It may represent an unusual primary disturbance of iron metabolism...
  3. ncbi Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats
    Sayuri Kojima
    The Institute of Environmental Toxicology, Joso shi, Ibaraki, Japan
    J Toxicol Sci 34:527-39. 2009
    ..The hematological analysis provided evidence for hypochromic anemia, plausibly caused by the impairment of iron utility.
  4. ncbi Genotyping of alpha-thalassemia in microcytic hypochromic anemia patients from North India
    Vaikam H Sankar
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Appl Genet 47:391-5. 2006
    Microcytic hypochromic anemia is a common condition in clinical practice and alpha-thalassemia has to be considered as a differential diagnosis. Molecular diagnosis of alpha-thalassemia is possible by polymerase chain reaction...
  5. ncbi A mutation in the gene for delta-aminolevulinic acid dehydratase (ALAD) causes hypochromic anemia in the medaka, Oryzias latipes
    Daigo Sakamoto
    Department of Biological Information, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Mech Dev 121:747-52. 2004
    ..affecting embryogenesis in the medaka, Oryzias latipes, identified a mutant, whiteout (who), that exhibited hypochromic anemia. The who mutant initially had the normal number of blood cells, but it then gradually decreased during the ..
  6. ncbi Microcytic hypochromic anemia patients with thalassemia: genotyping approach
    Fakher Rahim
    Research Center of Thalassemia and Hemoglobinopathies, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran
    Indian J Med Sci 63:101-8. 2009
    Microcytic hypochromic anemia is a common condition in clinical practice, and alpha-thalassemia has to be considered as a differential diagnosis.
  7. ncbi A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma
    Tomoko Akase
    Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
    Yakugaku Zasshi 123:817-24. 2003
    ..traditional herbal medicine) "Toki-shakuyaku-san" and an oral iron preparation in the treatment of hypochromic anemia associated with uterine myoma...
  8. ncbi Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
    Said Lyoumi
    INSERM U773, Paris, France
    Blood 109:811-8. 2007
    ..FECH deficiency induced microcytic hypochromic anemia without ringed sideroblasts, little or no hemolysis, and no erythroid hyperplasia...
  9. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008
    ..These mice exhibited microcytic, hypochromic anemia, as did lethally irradiated mice that received a transplant of Stat5a/b(-/-) fetal liver cells...
  10. doi Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia
    Roosy Aulakh
    Department of Pediatrics, Christian Medical College and Hospital, Ludhiana, Punjab, India
    Indian J Pediatr 76:265-8. 2009
    To study the utility of red cell distribution width (RDW) in the diagnosis of iron deficiency among children with microcytic hypochromic anemia.
  11. ncbi Innovative parameters RET-Y, sTfR, and sTfR-F index in patients with microcytic, hypochromic anemia--their special value for hemoglobinopathies
    Athanasia Agorasti
    Hematology Laboratory, General Hospital of Xanthi, Xanthi, Greece
    Lab Hematol 13:63-8. 2007
    ..For that purpose, a cohort of 141 patients with microcytic, hypochromic anemia, along with 58 healthy individuals, were evaluated in the present study...
  12. ncbi Varying intervals of subcutaneous epoetin alfa in hemodialysis patients
    Soheir Beshara
    Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
    J Nephrol 17:525-30. 2004
    ..The optimal subcutaneous (SC) epoetin alfa strategy is unestablished. The individual variability in dose requirements needs consideration. In this study, prolonged intervals were assessed in relation to varying dose requirements...
  13. ncbi Comparison of clinical outcomes of different erythropoietin usage strategies
    Murat Arslan
    Uludag University Faculty of Medicine, Department of Medical Oncology, Bursa, Turkey
    Tumori 90:394-8. 2004
    ..There is no comprehensive study that compares the different usage strategies of recombinant human erythropoietin (rHuEPO) in platinum-induced anemia. In order to clarify this issue, we conducted a prospective clinical study...
  14. ncbi Assessment of hematologic effects and fatigue in cancer patients with chemotherapy-induced anemia given darbepoetin alfa every two weeks
    Saroj Vadhan-Raj
    Section of Cytokines and Targeted Therapies, Anderson Cancer Center, Houston, TX 77030, USA
    J Support Oncol 1:131-8. 2003
    ....
  15. ncbi Treatment of cancer-related anemia with epoetin alfa: a review
    Erminia Ferrario
    Medical Oncology Unit B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Cancer Treat Rev 30:563-75. 2004
    ..Determining the timing of initiation of epoetin alfa is a clinical judgement; however, data suggest that patient functioning declines and the risk of transfusion increases when the Hb level falls under 12 g/dL...
  16. ncbi [Erythropoietin is a novel therapeutic option in the treatment of anemia caused by small cell lung cancer]
    Lilla Tamási
    Pulmonológiai Klinika, Semmelweis Egyetem, Budapest, 1125, Hungary
    Magy Onkol 50:243-6. 2006
    ..The adequate use of erythropoietin is of great help to the physician in the management of small cell lung cancer patients, by improving the quality of life...
  17. ncbi [Treatment of anemia in patients with chronic renal disease: is it time for self-criticism?]
    Lucia Del Vecchio
    U F Ipertensione e Nefrologia Preventiva, IRCCS Policlinico Multimedica, Sesto San Giovanni MI
    G Ital Nefrol 24:285. 2007
  18. ncbi [HbH disease--a rare differential diagnosis in a patient with anemia and abdominal pain]
    Ursula Fabry
    Medizinische Klinik IV, Universitatsklinikum Aachen
    Med Klin (Munich) 98:335-8. 2003
    A 45-year-old Vietnamese male was admitted to hospital with severe hypochromic anemia and acute abdominal pain. The peripheral blood smear showed extreme anisocytosis and poikilocytosis as well as teardrops and target cells...
  19. ncbi [Clinical analysis of CAPD-treated patients without anemia]
    Maria Majdan
    Katedry i Kliniki Nefrologii Akademii Medycznej w Lublinie
    Wiad Lek 56:14-8. 2003
    ..We conclude that spontaneous increase in Hb concentration in CAPD pts was not connected with increase in the serum endogenous Epo concentration. Factors other than Epo probably play a role in regulation of erythropoiesis in these pts...
  20. ncbi Mature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis: sensitivity and specificity
    Christophe Bovy
    Department of Nephrology, Laboratory of Hematology, CHU Sart Tilman, B35, B 4000 Liege, Belgium
    Nephrol Dial Transplant 22:1156-62. 2007
    ..The aim of this study was to assess the sensitivity and specificity of mature erythrocyte parameters in detecting functional iron deficiency (FID)...
  21. ncbi Clinical factors associated with achieving K/DOQI hemoglobin targets in hemodialysis patients
    Suying Li
    Nephrology Analytical Services, Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA
    Int Urol Nephrol 35:399-405. 2003
    ..Few studies have assessed treatable factors associated with achieving the Kidney Disease Outcomes Quality Initiative (K/DOQI) guideline of hemoglobin values of 11 to 12 g/dL in anemic hemodialysis patients...
  22. ncbi [Human recombinant erythropoietin-alpha increases the efficacy of irradiation in preclinical model]
    József Lövey
    Országos Onkológiai Intézet, Sugárterápiás, Budapest
    Magy Onkol 51:53-61. 2007
    ....
  23. ncbi Reticulocyte indices rapidly reflect an increase in iron availability for erythropoiesis
    Sanna Kotisaari
    Haematologica 88:1422-3. 2003
  24. ncbi Monitoring iron status in end-stage renal disease patients on hemodialysis
    Ali Rafi
    Kanoo Kidney Center, Dammam Medical Complex, Dammam, Saudi Arabia
    Saudi J Kidney Dis Transpl 18:73-8. 2007
    ..This is likely to make the diagnosis of iron status more accurate and may reduce the requirements and frequency of iron and r-HuEPO administration...
  25. ncbi Quality of life of patients with chronic renal allograft rejection and anemia
    Paolo Rebollo
    Health Outcomes Research Unit, Nephrology Unit 1, University Hospital of Asturias and Institute Reina Sofía for Nephrological Research of the FRIAT, Oviedo, Spain
    J Nephrol 17:531-6. 2004
    ..The objective of this study was to evaluate the HRQOL of patients with chronic allograft nephropathy (CAN) and anemia associated to RI, and the effect of rHuEPO treatment on the HRQOL...
  26. ncbi [The 10-minute consultation: anemia as a chance finding]
    H Heimpel
    Medizinische Universitätsklinik u Poliklinik, Ulm
    MMW Fortschr Med 146:55-6. 2004
  27. ncbi Cancer-related anemia: pathogenesis, prevalence and treatment
    Gunnar Birgegard
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Oncology 68:3-11. 2005
    ..These findings are noteworthy, since a growing body of clinical evidence indicates that the treatment of anemia can significantly improve patients' quality of life and may also improve the clinical outcome...
  28. ncbi Optimizing hemoglobin levels and beyond: strength for living and meaningful survival?
    Mario Dicato
    Luxembourg Medical Center, Luxembourg, Luxembourg
    Oncology 68:1-2. 2005
  29. ncbi Animal models with enhanced erythropoiesis and iron absorption
    Gladys O Latunde-Dada
    Department of Biochemistry and Nutrition Sciences Research Division, King s College London, Franklin Wilkin s Building, 150 Stamford Street, London SE1 9NH, UK
    Biochim Biophys Acta 1762:414-23. 2006
    ..These, respectively, experimental and genetic models of enhanced erythropoiesis highlight the shifting focus of iron absorption regulation from the marrow to the liver...
  30. ncbi Phase III study of two different dosing schedules of erythropoietin in anemic patients with cancer
    David P Steensma
    Mayo Clinic and Mayo Foundation, Rochester 55905, USA
    J Clin Oncol 24:1079-89. 2006
    ..To compare maintenance epoetin alfa administered once every 3 weeks with continued weekly epoetin alfa for patients with cancer-associated anemia...
  31. ncbi Alpha-thalassemia phenotype induced by the new IVS-II-2 (T --> A) splice donor site mutation on the alpha2-globin gene
    Cornelis L Harteveld
    Department of Human and Clinical Genetics, The Hemoglobinopathies Laboratory, Leiden University Medical Center, Leiden, The Netherlands
    Hemoglobin 30:3-7. 2006
    ..Direct sequencing of the alpha-globin genes revealed heterozygosity for a T --> A transversion at the IVS-II-2 position of the alpha2 gene. This is the first IVS-II splice donor site mutation described on the alpha2-globin gene...
  32. ncbi Once-weekly treatment of anemia in patients with cancer: a comparative review of epoetins
    Eric Pujade-Lauraine
    Service d Oncology, CHU Hotel Dieu, Paris, France
    Oncology 68:122-9. 2005
    ..The improved convenience and reduced administration costs associated with a once-weekly treatment may result in more patients receiving the benefits of epoetin therapy...
  33. ncbi Myelodysplastic patients with raised percentage of hypochromic red cells have evidence of functional iron deficiency
    P T Murphy
    Department of Haematology, Beaumont Hospital, Dublin 9, Ireland
    Ann Hematol 85:455-7. 2006
    ..Five of seven patients with elevated %HRC had satisfactory haemoglobin responses to a trial of human recombinant erythropoietin without iron supplementation...
  34. ncbi Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q
    Stephen D Nimer
    Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021 6007, USA
    J Clin Oncol 24:2576-82. 2006
    ..This review highlights some issues about the classification and treatment of del(5q) MDS...
  35. ncbi The use of growth factors to manage the hematologic side effects of PEG-interferon alfa and ribavirin
    Rochelle S Collantes
    Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, VA 22042, USA
    J Clin Gastroenterol 39:S9-13. 2005
    ....
  36. ncbi Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy
    Bassem I Razzouk
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 24:3583-9. 2006
    ..To evaluate the effects of once-weekly epoetin alfa (EPO) on health-related quality of life (HRQOL), hemoglobin (Hb), transfusions, and tolerability in children with cancer...
  37. ncbi Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics and Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:2075-81. 2004
    ..Larger studies on the association between anemia and these outcomes are warranted...
  38. ncbi Anemia and impaired stress-induced erythropoiesis in aceruloplasminemic mice
    Srujana Cherukuri
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Blood Cells Mol Dis 33:346-55. 2004
    ..Thus, Cp(-/-) have mild microcytic, hypochromic anemia consistent with normal red cell formation but defective iron availability...
  39. ncbi Every-three-week administration of darbepoetin alfa in women with chemotherapy-associated anemia
    Adrian L Goram
    Hematology Oncology and Medicine, Sacred Heart Health System, Pensacola, FL 32505, USA
    Am J Health Syst Pharm 63:1522-7. 2006
    ..The effectiveness of every-three-week administration of darbepoetin alfa in women with chemotherapy-associated anemia was evaluated...
  40. ncbi Evolving treatment strategies for anaemia in cancer: experience with epoetin beta
    Matti Aapro
    Institut Multidisciplinaire d Oncologie, Clinique de Genolier, Switzerland
    Oncology 67:17-22. 2004
    ..The findings of such studies are expected to lead to a greater understanding of the optimal use of epoetins in cancer-related anaemia...
  41. ncbi Optimising anaemia management with epoetin beta
    Nicholas Reed
    Beatson Oncology Centre, Glasgow, UK
    Oncology 67:12-6. 2004
    ..Once weekly administration of epoetin beta offers greater convenience and should reduce administration costs compared with the tiw regimen...
  42. ncbi Can erythropoietin therapy improve survival?
    John Glaspy
    University of California, Los Angeles School of Medicine, 90095, USA
    Oncology 67:5-11. 2004
    ..These results suggest that treatment of anaemic patients with cancer with epoetin beta is effective and safe...
  43. ncbi Epoetin versus darbepoetin conundrum compromise
    Archie Bleyer
    J Clin Oncol 24:e46. 2006
  44. ncbi Standard of care for cancer-related anemia: improving hemoglobin levels and quality of life
    Enrico Cortesi
    Dipartimento Medicina Sperimentale e Patologia, Universita di Roma, Rome, Italy
    Oncology 68:22-32. 2005
    ..Ongoing research will continue to provide new insights into best management of anemia with epoetin alfa in cancer patients...
  45. ncbi [Iron, infection and anemia--a classical triad]
    Gunter Weiss
    Universitatsklinik fur Innere Medizin, Innsbruck, Osterreich
    Wien Klin Wochenschr 114:357-67. 2002
    ..The sole application of iron should be strictly avoided due to promotion of pathogen growth and impairment of immune function...
  46. ncbi [Treatment with low doses of intravenous iron does not modify hemoglobin nor the erythropoietin dosage]
    J Fernández-Gallego
    Nefrologia 26:143-4. 2006
  47. pmc Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia
    Freya J I Fowkes
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 5:e56. 2008
    ..We tested the hypothesis that the erythrocyte indices associated with alpha(+)-thalassaemia homozygosity provide a haematological benefit during acute malaria...
  48. ncbi The cost-effectiveness of treatment with erythropoietin compared to red blood cell transfusions for patients with chemotherapy induced anaemia: a Markov model
    Sixten Borg
    The Swedish Institute for Health Economics IHE, Lund, Sweden
    Acta Oncol 47:1009-17. 2008
    ..It is generally accepted that symptomatic anaemia should be corrected. Treatment options include red blood cell transfusion (RBCT), erythropoietin (EPO) administration or a combination of both...
  49. ncbi [Anemia and iron metabolism]
    Hideo Harigae
    Rinsho Ketsueki 49:1285-90. 2008
  50. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991
    ..37; P less than 0.05). A significant correlation was found between serum TF levels and plasma IGF-1 levels (r = 0.45; P less than 0.05). These data indicate that serum TF levels may be a marker of skeletal growth in normal boys...
  51. ncbi Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994)
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Arch Intern Med 162:1401-8. 2002
    ..Kidney failure is known to cause anemia, which is associated with a higher risk of cardiac failure and mortality. The impact of milder decreases in kidney function on hemoglobin levels and anemia in the US population, however, is unknown...
  52. ncbi Epoetin alpha in elective coronary and valve surgery in Jehovah's Witnesses patients. Experience in 45 patients
    A Podesta
    Cattedra di Cardiochirurgia, Universita degli Studi, Genova, Italy
    Minerva Cardioangiol 50:125-31. 2002
    ..The religious beliefs of Jehovah's Witnesses who refuse homologous and autologous blood transfusion poses serious problems for surgeons when operating on patients requiring a mean transfusion requirement of =/>2 units of blood...
  53. ncbi [Erythropoietin and hip surgery in an anemic Jehovah's Witness with ankylosing spondylitis, chronic liver disease, and Crohn's disease]
    J M Grasa
    Rev Esp Anestesiol Reanim 49:113-4. 2002
  54. ncbi [Erythropoietin resistance]
    Bernard Branger
    Nephrologie 23:3-5. 2002
  55. ncbi Single value of serum transferrin receptor is not diagnostic for the absence of iron stores in anaemic patients with rheumatoid arthritis
    S Siebert
    Department of Rheumatology, University Hospital of Wales and University of Wales College of Medicine, Cardiff, UK
    Clin Lab Haematol 25:155-60. 2003
    ....
  56. ncbi Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport
    P J Kingston
    Br J Haematol 40:265-76. 1978
    ..The sla gene is already known to have a major effect in reducing iron transport in the small intestine. The present studies provide evidence of an analogous defect in placental iron transport...
  57. ncbi Maintaining iron balance in women blood donors of childbearing age: summary of a workshop
    Celso Bianco
    America s Blood Centers, Washington, DC, USA
    Transfusion 42:798-805. 2002
  58. ncbi Attitude of physicians in Saudi Arabia towards anemia treatment strategies in patients with chronic kidney disease
    Muhammad Ziad Souqiyyeh
    Saudi Center for Organ Transplantation, Riyadh, Kingdom of Saudi Arabia
    Saudi J Kidney Dis Transpl 18:65-72. 2007
    ..More studies are required to explore the quality of services rendered to the CKD patients and guidelines need to be outlined for the management of anemia in the CKD patients...
  59. ncbi Incidence of high erythrocyte count in infants and young children with iron deficiency anemia: re-evaluation of an old parameter
    Deniz Aslan
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    J Pediatr Hematol Oncol 25:303-6. 2003
    ..0 x 106/microL) in infants and young children with iron deficiency anemia and to document the differences in hematologic parameters at diagnosis and during iron therapy in IDA patients with and without a high erythrocyte count...
  60. ncbi Efficacy of Tokishakuyakusan on the anemia in the iron-deficient pregnant rats
    Tomoko Akase
    Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 3 3165 Higashi Tamagawagakuen, Machida, Tokyo 194 8543, Japan
    Biol Pharm Bull 30:1523-8. 2007
    ..These findings suggested that Tokishakuyakusan promotes erythrocyte differentiation in iron-deficiency anemia, and that it possesses anemia-ameliorating efficacy...
  61. ncbi Serum transferrin receptor is a marker of iron deficiency in patients included in programs for preoperative autologous blood donation
    Donato Dimonte
    Blood Transfusion Service, Azienda Ospedaliera Policlinico, C R C C, Piazza Giulio Cesare 11, Bari 70123, Italy
    Transfus Apher Sci 27:211-6. 2002
    ..The aim of this study was to evaluate the use of the serum transferrin receptor (sTfR) for the assessment of IDE in patients undergoing PABD...
  62. ncbi Assessing symptom burden using the M. D. Anderson symptom inventory in patients with chemotherapy-induced anemia: results of a multicenter, open-label study (SURPASS) of patients treated with darbepoetin-alpha at a dose of 200 microg every 2 weeks
    Janice L Gabrilove
    Division of Hematology Oncology, Mount Sinai Medical Center, New York, New York, USA
    Cancer 110:1629-40. 2007
    ....
  63. ncbi Intravenous iron for CAPD populations: proactive or reactive strategies?
    D Richardson
    Department of Renal Medicine, St James s University Hospital, Beckett St, Leeds, UK
    Nephrol Dial Transplant 16:115-9. 2001
    ..The European best practice guideline [Nephrol Dial Transplant 1999; 14 (Suppl 5)] (5A) for the management of anaemia suggests that > 85% of the CAPD population should have a haemoglobin level of > 11.0 g/dl...
  64. ncbi Kinetic aspects of endogenous carbon monoxide production in experimental animals
    S A Landaw
    Ann N Y Acad Sci 174:32-48. 1970
  65. ncbi Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test
    A el-Beshlawy
    Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
    East Mediterr Health J 13:780-6. 2007
    ..For the one-tube osmotic fragility test, sensitivity was 87.0% and specificity 34.1%; the test has limited use for a mass screening programme in Egypt, where iron deficiency is prevalent...
  66. ncbi Erythropoiesis and iron
    I Cavill
    Department of Haematology, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Best Pract Res Clin Haematol 15:399-409. 2002
    ....
  67. doi [Diagnosis and therapy of renal anemia]
    Janos Szegedi
    Szabolcs Szatmár Bereg megyei Onkormányzat Jósa András Oktató Kórház I Belgyógyászati Osztály, Braun Avitum Hungary Zrt, 2 Dialízisközpont Nyíregyháza Szent István u 68 4400
    Orv Hetil 149:251-5. 2008
    ..When selecting the appropriate treatment strategy for each patient, the application method, the effect range and cost efficiency of the selected erythropoietin product must be taken into consideration...
  68. doi [Hemoglobin variability in chronic renal failure patients]
    Zoltan Kiss
    Amgen Kft Orvostudományi Osztály Budapest Szabadság tér 7 1054
    Orv Hetil 149:1925-34. 2008
    ..Finally, based on the available data, the results of future research, and on board scientific consensus, in a strategy for treatment of renal anemia, we should take into account the questions related to Hb stability and variability...
  69. ncbi Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor
    Murugesan Ram Prabahar
    Department of Nephrology, Sri Ramachandra Medical College, Sri Ramachandra University, Chennai, Tamilnadu, India
    Saudi J Kidney Dis Transpl 19:964-8. 2008
    ..work up for anemia showed normal white cell and platelet count while peripheral smear showed microcytic hypochromic anemia with few target cells. Hemoglobin electrophoresis revealed hemoglobin A of 92%, hemoglobin A2 of 6...
  70. doi Systemic lupus erythematosus in the Fars Province of Iran
    M A Nazarinia
    Rheumatology Department of Shiraz University of Medical Sciences, Shiraz, Iran
    Lupus 17:221-7. 2008
    ..8%) patients represented hypocomplementemia. Regarding hematological manifestations, 74.5% had microcytic hypochromic anemia, 64.6% had leukopenia, and 44.6% had thrombocytopenia; 18 (4...
  71. ncbi Alpha-2-globin gene polyadenylation (AATAAA-->AATAAG) mutation in hemoglobin H disease among Kuwaitis
    M Haider
    Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 14:73-6. 2005
    ..Here we document the clinical and hemato logical characteristics of children with Hb H disease being followed in Kuwait...
  72. doi Oxidative stress in blood of camels (Camelus dromedaries) naturally infected with Trypanosoma evansi
    Mostafa A Saleh
    Animal Health Research Institute, El Kharga, El Wadi El Gadid 725211, Egypt
    Vet Parasitol 162:192-9. 2009
    ..The infected camels were characterized by macrocytic hypochromic anemia. Trypanosomiasis in camels resulted in significant (P<0.001) stimulation of serum NO (78.93%), eMDA (110...
  73. pmc Hemolysis, myopathy, and cardiac disease associated with hereditary phosphofructokinase deficiency in two Whippets
    Karen Gerber
    Axiom Veterinary Laboratory, Newton Abbott, UK
    Vet Clin Pathol 38:46-51. 2009
    ..Persistent macrocytic hypochromic anemia with marked reticulocytosis and metarubricytosis was found when CBC results were compared with reference ..
  74. ncbi Failure of biliopancreatic diversion in Prader-Willi syndrome
    G Grugni
    Department of Auxology, IRCCS S Giuseppe Hospital, Istituto Auxologico Italiano Foundation, Verbania, 28921 Italy
    Obes Surg 10:179-81; discussion 182. 2000
    ..In a small number of patients, favorable results have been reported with biliopancreatic diversion (BPD)...
  75. ncbi Beta-thalassemia intermedia in a Brazilian patient with-101 (C > T) and codon 39 (C > T) mutations
    Sylvia Morais de Sousa
    Centro de Biologia Molecular Estrutural e Engenharia Genética, Hemocentro, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Sao Paulo Med J 121:28-30. 2003
    ..The blood cell count revealed microcytic and hypochromic anemia (hemoglobin = 6...
  76. ncbi Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of mice
    A E Schultze
    Department of Pathology, The University of Tennessee, Knoxville 37901 1071, USA
    Lab Anim Sci 49:260-8. 1999
    Previous investigation of fitness1(4226SB) mice revealed growth retardation and microcytic, hypochromic anemia with functional iron deficiency. Serum biochemical analysis suggested protein-losing enteropathy and liver dysfunction.
  77. ncbi [Multicentric inflammatory pseudotumor with asynchronic presentation in meninges, liver, spleen and lymph nodes in a patient with seronegative spondiloarthropathy. Case report and review of the literature]
    R M Vicuña-González
    Servicio de Anatomia Patologica, Hospital Central Sur de Alta Especialidad de Petroleos Mexicanos, Delegacion Tlalpan, Mexico DF, Mexico
    Rev Neurol 47:464-8. 2008
    ..The cases with central nervous system affection have been described in meninges, brain, choroid plexus and cranial and spinal nerves. Multicentric cases, synchronous and asynchronous have been described...
  78. ncbi [Homozygous hemoglobin-E (Hb-EE) disease]
    G Amendola
    Ematologia, Oncologia Pediatrica
    Pediatr Med Chir 26:65-7. 2004
    ..She showed a mild microcytic, hypochromic anemia with a normal iron balance; clinical examination was normal with neither pallor nor icterus nor splenomegaly;..
  79. doi Hyporesponsiveness to erythropoietin: causes and management
    James Elliott
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA
    Adv Chronic Kidney Dis 16:94-100. 2009
    ..Aluminum intoxication is a rare cause of iron-restricted erythropoiesis that may manifest as microcytic hypochromic anemia. A decrease in serum albumin concentration may signal the presence of inflammation, which may be manifest (..
  80. ncbi [A case of uterine carcinosarcoma]
    E Spaziani
    Universita degli Studi di Roma La Sapienza, I Facolta di Medicina e Chirurgia, Polo Pontino, Ospedale A Fiorino, Terracina LT, U O C di Chirurgia Generale Universitaria
    G Chir 29:365-8. 2008
    ..a case of carcinosarcoma in a 82-year old woman with a vaginal bleeding since 10 months and an ingravescent hypochromic anemia. The RMN of the abdomen and pelvis showed a mass occupying the whole uterine lumen, without signs of pelvic ..
  81. ncbi Congenital sideroblastic anemia treated as thalassemia major
    R K Chowdhury
    Endocrine Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    Mymensingh Med J 19:636-9. 2010
    Sideroblastic anemia is a rare cause of microcytic hypochromic anemia. In Bangladesh, most common causes of microcytic anemia are iron deficiency anemia, anemia of chronic diseases and thalassemia...
  82. ncbi A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia
    Rupert A J Ransford
    Department of Gastroenterology, County Hospital, Union Walk, Hereford, UK
    J Clin Gastroenterol 35:228-33. 2002
    ..The characteristics of celiac patients identified by screening require further study...
  83. ncbi Presumptive Babesia ovis infection in a spanish ibex (Capra pyrenaica)
    I Marco
    Servicio de Ecopatologia de Fauna Salvaje, School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain
    Vet Parasitol 87:217-21. 2000
    ..haemoglobin concentration (MCHC) were decreased and mean corpuscular volume (MCV) increased (macrocytic-hypochromic anemia)...
  84. ncbi Acute myeloid leukemia with multilineage dysplasia in an alpaca
    Jennifer D Steinberg
    Department of Microbiology, Immunology and Pathology, Washington State University, Monoclonal Antibody Center, Pullman, WA, USA
    Vet Clin Pathol 37:289-97. 2008
    ..Abnormalities on the CBC included neutropenia, thrombocytosis, and severe nonregenerative, macrocytic, hypochromic anemia. Dysplastic nucleated erythrocytes and micromegakaryocytes were observed on the peripheral blood smear...
  85. pmc Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, 75014 Paris, France
    Proc Natl Acad Sci U S A 99:4596-601. 2002
    ..These transgenic animals had decreased body iron levels and presented severe microcytic hypochromic anemia. So far, three mosaic transgenic animals have survived...
  86. ncbi Treatment of iron deficiency anemia with Ferro-Folgamma
    Mihaela Maria Ghinea
    Clinic of Internal Medicine, Constanta, Romania
    Rom J Intern Med 42:225-30. 2004
    Iron deficiency anemia is a hypochromic anemia in which hemoglobin poor synthesis is due to a decrease in the amount of iron in the body...
  87. ncbi Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation
    Elisa Granjo
    Department of Hematology, Hospital S Joao, Porto, Portugal
    Int J Hematol 75:484-8. 2002
    We report the case of a boy with hereditary spherocytosis who presented with mild microcytic hypochromic anemia and recurrent leg ulcers that had been present since childhood...
  88. ncbi Refinement of the genetic cause of ATR-16
    Cornelis L Harteveld
    Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center LUMC, 2333RC Leiden, The Netherlands
    Hum Genet 122:283-92. 2007
    ..This would plead for more alertness when a persistent microcytic hypochromic anemia at normal ferritin levels is observed as suggestive for the ATR-16 syndrome...
  89. ncbi Iatrogenic copper deficiency associated with long-term copper chelation for treatment of copper storage disease in a Bedlington Terrier
    M A Seguin
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Vet Med Assoc 218:1593-7, 1580. 2001
    ..A CBC revealed microcytic hypochromic anemia. High serum activities of liver enzymes, high bile acid concentrations, and low BUN and albumin ..
  90. ncbi Idiopathic pulmonary hemosiderosis with cystic lesions: a rare presentation
    I Godoy
    Department of Internal Medicine, Botucatu School of Medicine, Universidade Estadual Paulista, Brazil
    Am J Med Sci 319:411-3. 2000
    ..Laboratory studies revealed normocytic hypochromic anemia and normal coagulation tests. C-reactive protein and mucoproteins were negative...
  91. ncbi Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity
    Tanya A M Griffiths
    Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Biochemistry 44:14725-31. 2005
    ..Mutations in the murine hephaestin gene (sla) produce microcytic, hypochromic anemia that is refractory to oral iron therapy...
  92. doi Iron deficiency causes duodenum mucosal hyperplasia in male Wistar rats
    G Coelho Palermo Cunha
    BASF SE, Experimental Toxicology and Ecology, Z 470, 67056 Ludwigshafen, Germany
    Toxicol Lett 177:156-67. 2008
    ..diet to Wistar rats resulted within 14 days in reduced serum iron concentrations, a microcytic hypochromic anemia, characteristic for impaired hemoglobin synthesis, and an increase of duodenal epithelial cell proliferation...
  93. ncbi Sideroblastic anemia in 7 dogs (1996-2002)
    Douglas J Weiss
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    J Vet Intern Med 19:325-8. 2005
    Sideroblastic anemia is an anemic condition characterized by chronic hypochromic anemia and the presence of large iron deposits in erythroid cells. Seven dogs with sideroblastic anemia were evaluated retrospectively...
  94. ncbi The molecular formula and proposed structure of the iron-dextran complex, imferon
    E London
    School of Pharmacy and Biomedical Sciences, St Michael s Building, White Swan Road, University of Portsmouth, Portsmouth, PO1 2DT, UK
    J Pharm Sci 93:1838-46. 2004
    ..This new complex soon became the most widely used parental therapy for hypochromic anemia in humans. No molecular formula has been proposed, but Cox has attributed an outline structure to it...
  95. ncbi Scanning of beta-globin gene for identification of beta-thalassemia mutation in Romanian population
    R Talmaci
    Human Genetics Department, Genetics Institute of Bucharest University, Aleea Portocalilor nr 1 3, 76258, Bucharest, Romania
    J Cell Mol Med 8:232-40. 2004
    ..5%) in the Romanian population, but it must be considered in the differential diagnosis of hypochromic anemia. The molecular characterization of beta-thalassemia is absolutely necessary for molecular diagnosis, as well ..
  96. pmc Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis
    Julio D Amigo
    Department of Medicine, Division of Hematology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 31:1344-56. 2011
    ..A genetic deficiency of Mfrn1 results in a profound hypochromic anemia in vertebrate species...
  97. doi A new alpha(0)-thalassemia deletion found in a Dutch family (--(AW))
    Marion Phylipsen
    Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Blood Cells Mol Dis 45:133-5. 2010
    Alpha-thalassemia is an inherited hemoglobin disorder characterized by a microcytic hypochromic anemia caused by a quantitative reduction of the alpha-globin chain...
  98. ncbi Hematologic risk factors for stroke in Saudi children
    Mustafa A Salih
    Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia
    Saudi Med J 27:S21-34. 2006
    ..To explore the hematologic risk factors for stroke in a cohort of Saudi children...
  99. ncbi Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma
    Veronica Marchetti
    Department of Veterinary Clinics, University of Pisa, Italy
    Vet Clin Pathol 34:259-63. 2005
    ..Results of a CBC showed severe, microcytic, hypochromic anemia with mild eosinophilia (2944 cells/microL, reference interval 100-1250/microL) and thrombocytosis...
  100. ncbi [Sonographic diagnosis of Bouveret's syndrome]
    J Guntau
    2 Medizinische Klinik, Albertinenkrankenhaus Hamburg
    Dtsch Med Wochenschr 132:315-8. 2007
    ..MEDICAL HISTORY: A 76-year-old woman with known dementia was admitted to hospital for postprandial vomiting and increasing upper abdominal pain for 2 days. Gallstones and a chronic cholecystitis had been previously documented...
  101. ncbi Celiac disease as a rare cause of primary amenorrhea: a case report
    Mandakini Pradhan
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, U P, India
    J Reprod Med 52:453-5. 2007
    ..Primary amenorrhea can be due to abnormal functioning of the hypothalamic-pituitary axis or malformation of müllerian structures. Malnutrition due to chronic malabsorption can alter the axis and can be a cause of primary amenorrhea...

Research Grants79

  1. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2006
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  2. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2010
    ..pnt exhibits hypochromic anemia. pnt has a defect in hemoglobinisation while preserving red cell numbers...
  3. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2009
    ..To date, we have uncovered over eight complementation groups of hypochromic anemia. In this proposal, we plan to extend our observations by characterizing the globin locus of the zebrafish, ..
  4. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2010
    ..To date, we have uncovered over eight complementation groups of hypochromic anemia. In this proposal, we plan to extend our observations by characterizing the globin locus of the zebrafish, ..
  5. HUMAN RETICULOCYTE EIF-2ALPHA KINASE & HEME DEFICIENCY
    ORLANDO MARTELO; Fiscal Year: 1980
    ..These studies should clarify the mechanism of the hypochromic anemia associated with iron deficiency, the sideroblastic anemias, certain cases of preleukemia, and lead poisoning. ..
  6. Frascati: mitochondrial transporter and erythropoiesis
    Barry Paw; Fiscal Year: 2009
    ..Mutations in the zebrafish frascati gene lead to a profound hypochromic anemia and a developmental arrest at the pro- erythroblast stage...
  7. Frascati: mitochondrial transporter and erythropoiesis
    Barry H Paw; Fiscal Year: 2010
    ..Mutations in the zebrafish frascati gene lead to a profound hypochromic anemia and a developmental arrest at the pro- erythroblast stage...
  8. Frascati: mitochondrial transporter and erythropoiesis
    Barry Paw; Fiscal Year: 2007
    ..Mutations in the zebrafish frascati gene lead to a profound hypochromic anemia and a developmental arrest at the pro- erythroblast stage...
  9. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2004
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  10. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2006
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  11. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2003
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  12. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2005
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  13. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2002
    ..mutants generated in a large scale chemical mutagenesis screen, I have identified another mutant with hypochromic anemia, HF107, that maps to a novel locus on zebrafish chromosome 20...
  14. Frascati-mediated Iron Metabolism in Erythroblasts
    Barry Paw; Fiscal Year: 2007
    ..Mutations in the zebrafish frascati gene lead to a profound hypochromic anemia and maturation arrest at the pro-erythroblast stage...
  15. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2009
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  16. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  17. ABI 3730xl DNA Analyzer
    David Bishop; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2009
    ..Long-term ill effects continuing into adolescence, despite iron therapy in infancy, could therefore have major public health implications. ..
  19. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2010
    ....
  20. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2005
    ..These studies will contribute greatly to advances in the fields of stem cell transplantation and immune regulation. ..
  21. DNA SEQUENCING/GENOTYPING CORE FACILITY
    David Bishop; Fiscal Year: 2005
    ..They will also identify and recommend novel strategies, technologies, instrumentation, and resources to further facilitate and foster cutting-edge cancer and other research. ..
  22. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  23. Neurodevelopmental Outcome in Russian Orphanage
    Laurie Miller; Fiscal Year: 2004
    ..abstract_text> ..
  24. The function of I(3)mbt in hematopoietic cancers
    Stephen Nimer; Fiscal Year: 2006
    ..The PcG family of proteins is being increasingly implicated in carcinogenesis, and these studies will provide insights into the role that l(3)mbt plays in hematologic malignancies. ..
  25. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2010
    ....
  26. The function of I(3)mbt in hematopoietic cancers
    Stephen Nimer; Fiscal Year: 2007
    ..The PcG family of proteins is being increasingly implicated in carcinogenesis, and these studies will provide insights into the role that l(3)mbt plays in hematologic malignancies. ..
  27. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2008
    ..Long-term ill effects continuing into adolescence, despite iron therapy in infancy, could therefore have major public health implications. ..
  28. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2007
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  29. HRI/elF2aP Signaling Pathway as Potential Pharmaceutical Targets for Thalassemia
    Jane Jane Chen; Fiscal Year: 2008
    ..This study may also lead to the discovery of novel drug treatments for red blood cell diseases. ..
  30. INVESTIGATIVE HEMATOLOGY
    Daniel Salomon; Fiscal Year: 2008
    ..The training faculty for this program work in approximately 30,000 square feet of laboratory space used exclusively for biomedical research ..
  31. REGULATION OF PROTEIN SYNTHESIS AND ERYTHROPOIESIS
    Jane Jane Chen; Fiscal Year: 2008
    ..The small chemicals discovered in this proposed research might also have great potential in helping to treat drug-resistant cancer cells. ..
  32. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2008
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  33. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2007
    ..Long-term ill effects continuing into adolescence, despite iron therapy in infancy, could therefore have major public health implications. ..
  34. Brain and Behavior in Early Iron Deficiency
    Betsy Lozoff; Fiscal Year: 2007
    ..Collectively, the program will make a major contribution in understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder. ..
  35. FUNCTIONAL SIGNIFICANCE OF EARLY IRON DEFICIENCY
    Betsy Lozoff; Fiscal Year: 2007
    ..abstract_text> ..
  36. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2007
    ..abstract_text> ..
  37. The function of I(3)mbt in hematopoietic cancers
    Stephen Nimer; Fiscal Year: 2004
    ..The PcG family of proteins is being increasingly implicated in carcinogenesis, and these studies will provide insights into the role that l(3)mbt plays in hematologic malignancies. ..
  38. Vitamin D3 inducible Genes Mediating Differentiation
    Stephen Nimer; Fiscal Year: 2002
    ..The functional requirement of the DRIP coactivator complex in mediating VDR and RAR transactivation, in the context of nuclear receptor-dependent myeloid differentiation, will be determined. ..
  39. REGULATION OF PROTEIN SYNTHESIS AND ERYTHROPOIESIS
    Jane Jane Chen; Fiscal Year: 2001
    ....
  40. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2000
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  41. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 1999
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  42. REGULATION OF PROTEIN SYNTHESIS AND ERYTHROPOIESIS
    Jane Jane Chen; Fiscal Year: 1999
    ....
  43. NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTS
    Betsy Lozoff; Fiscal Year: 1999
    ..s. ..
  44. STRUCTURE/FUNCTION OF HEME REGULATED ELF-2ALPHA KINASE
    Jane Jane Chen; Fiscal Year: 1999
    ..Structure-function analysis of HRI will advance our knowledge not only on the regulation of protein kinases which are vital in the regulation of various cellular processes, but also on the regulation of heme proteins. ..
  45. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2002
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  46. STRUCTURE/FUNCTION OF HEME REGULATED ELF-2ALPHA KINASE
    Jane Jane Chen; Fiscal Year: 2000
    ..Structure-function analysis of HRI will advance our knowledge not only on the regulation of protein kinases which are vital in the regulation of various cellular processes, but also on the regulation of heme proteins. ..
  47. Vitamin D3 inducible Genes Mediating Differentiation
    Stephen Nimer; Fiscal Year: 2004
    ..The functional requirement of the DRIP coactivator complex in mediating VDR and RAR transactivation, in the context of nuclear receptor-dependent myeloid differentiation, will be determined. ..
  48. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2004
    ..These studies will contribute greatly to advances in the fields of stem cell transplantation and immune regulation. ..
  49. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2004
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  50. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2002
    ..These studies will contribute greatly to advances in the fields of stem cell transplantation and immune regulation. ..
  51. The function of I(3)mbt in hematopoietic cancers
    Stephen Nimer; Fiscal Year: 2003
    ..The PcG family of proteins is being increasingly implicated in carcinogenesis, and these studies will provide insights into the role that l(3)mbt plays in hematologic malignancies. ..
  52. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2003
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  53. Neuromaturational Delays in Iron Deficient Anemic Infant
    Betsy Lozoff; Fiscal Year: 2003
    ....
  54. High-Throughput Robotic Liquid Handling System
    David Bishop; Fiscal Year: 2003
    ..Our expert and experienced DNAcore Directors and staff will effectively and rapidly integrate the requested high-throughput robotics system into our established central core facility to significantly increase its capabilities. ..
  55. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2006
    ..The projected studies should improve our understanding of control of iron metabolism and make possible detection of those cases of hemochromatosis who are likely to become clinically affected. ..
  56. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2000
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  57. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  58. NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTS
    Betsy Lozoff; Fiscal Year: 1999
    ..s. ..
  59. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2001
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  60. Neuromaturational Delays in Iron Deficient Anemic Infant
    Betsy Lozoff; Fiscal Year: 2002
    ....
  61. INVESTIGATIVE HEMATOLOGY
    Ernest Beutler; Fiscal Year: 2007
    ..The training faculty for this program work in approximately 30,000 square feet of laboratory space used exclusively for biomedical research ..
  62. Neuromaturational Delays in Iron Deficient Anemic Infant
    Betsy Lozoff; Fiscal Year: 2004
    ....
  63. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2009
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  64. The function of I(3)mbt in hematopoietic cancers
    Stephen Nimer; Fiscal Year: 2005
    ..The PcG family of proteins is being increasingly implicated in carcinogenesis, and these studies will provide insights into the role that l(3)mbt plays in hematologic malignancies. ..
  65. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2007
    ....
  66. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2003
    ..The projected studies should improve our understanding of control of iron metabolism and make possible detection of those cases of hemochromatosis who are likely to become clinically affected. ..
  67. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2001
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  68. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2007
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  69. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2009
    ..We hope that the information gained can be exploited to improve the therapeutic index of current cancer treatments and devise new therapeutic approaches. ..