eclampsia

Summary

Summary: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Top Publications

  1. ncbi Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Am Heart J 156:918-30. 2008
  2. pmc Identifying barriers to the availability and use of Magnesium Sulphate Injection in resource poor countries: a case study in Zambia
    Anna L Ridge
    Medicine Access and Rational Use, Department of Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland
    BMC Health Serv Res 10:340. 2010
  3. doi Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre, Groningen, Netherlands
    Lancet 374:979-88. 2009
  4. doi The global impact of pre-eclampsia and eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford, UK
    Semin Perinatol 33:130-7. 2009
  5. ncbi Late postpartum eclampsia: a preventable disease?
    Mark C Chames
    Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, OH, USA
    Am J Obstet Gynecol 186:1174-7. 2002
  6. ncbi Maternal mortality from preeclampsia/eclampsia
    Labib Ghulmiyyah
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Semin Perinatol 36:56-9. 2012
  7. doi Stroke in pregnant and postpartum women
    Evgeny V Sidorov
    Beth Israel Deaconess Medical Centre, Boston, MA, USA
    Expert Rev Cardiovasc Ther 9:1235-47. 2011
  8. ncbi Outcomes of severe pre-eclampsia/eclampsia in Yorkshire 1999/2003
    D J Tuffnell
    Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
    BJOG 112:875-80. 2005
  9. ncbi Magnesium sulfate therapy in preeclampsia and eclampsia
    A G Witlin
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555 0587, USA
    Obstet Gynecol 92:883-9. 1998
  10. ncbi Cerebrovascular function in pregnancy and eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hypertension 50:14-24. 2007

Detail Information

Publications289 found, 100 shown here

  1. ncbi Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Am Heart J 156:918-30. 2008
    Preeclampsia affects 3% to 5% of gestations and eclampsia 0.05% to 0.93%, but their subsequent cardiovascular sequelae are unclear...
  2. pmc Identifying barriers to the availability and use of Magnesium Sulphate Injection in resource poor countries: a case study in Zambia
    Anna L Ridge
    Medicine Access and Rational Use, Department of Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland
    BMC Health Serv Res 10:340. 2010
    Pre-eclampsia and eclampsia are serious complications of pregnancy and major causes of maternal mortality and morbidity worldwide...
  3. doi Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre, Groningen, Netherlands
    Lancet 374:979-88. 2009
    ..We investigated whether induction of labour in women with a singleton pregnancy complicated by gestational hypertension or mild pre-eclampsia reduces severe maternal morbidity.
  4. doi The global impact of pre-eclampsia and eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford, UK
    Semin Perinatol 33:130-7. 2009
    ..Overall, 10% to 15% of direct maternal deaths are associated with preeclampsia and eclampsia. Where maternal mortality is high, most of deaths are attributable to eclampsia, rather than preeclampsia...
  5. ncbi Late postpartum eclampsia: a preventable disease?
    Mark C Chames
    Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, OH, USA
    Am J Obstet Gynecol 186:1174-7. 2002
    The purpose of this study was to determine whether there is a shift in the timing of eclampsia in relation to delivery and whether traditional symptoms precede impending postpartum eclampsia.
  6. ncbi Maternal mortality from preeclampsia/eclampsia
    Labib Ghulmiyyah
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Semin Perinatol 36:56-9. 2012
    Preeclampsia/eclampsia is one of the 3 leading causes of maternal morbidity and mortality worldwide...
  7. doi Stroke in pregnant and postpartum women
    Evgeny V Sidorov
    Beth Israel Deaconess Medical Centre, Boston, MA, USA
    Expert Rev Cardiovasc Ther 9:1235-47. 2011
    ..and are etiologically related to three conditions: reversible cerebral vasoconstriction syndrome, preeclampsia/eclampsia and cerebral venous thrombosis...
  8. ncbi Outcomes of severe pre-eclampsia/eclampsia in Yorkshire 1999/2003
    D J Tuffnell
    Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
    BJOG 112:875-80. 2005
    To establish the risk of serious complications from severe pre-eclampsia and eclampsia in a region using a common guideline for the management of these conditions.
  9. ncbi Magnesium sulfate therapy in preeclampsia and eclampsia
    A G Witlin
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555 0587, USA
    Obstet Gynecol 92:883-9. 1998
    To review the available evidence regarding efficacy, benefits, and risks of magnesium sulfate seizure prophylaxis in women with preeclampsia or eclampsia.
  10. ncbi Cerebrovascular function in pregnancy and eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hypertension 50:14-24. 2007
  11. ncbi ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists
    Barrett M Schroeder
    Am Fam Physician 66:330-1. 2002
  12. ncbi A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia
    Michael A Belfort
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    N Engl J Med 348:304-11. 2003
    Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia. Nimodipine is a calcium-channel blocker with specific cerebral vasodilator activity...
  13. ncbi Diagnosis, prevention, and management of eclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Obstet Gynecol 105:402-10. 2005
    ..Cerebral imaging suggests that cerebral abnormalities in eclampsia (mostly vasogenic edema) are similar to those found in hypertensive encephalopathy...
  14. ncbi Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy
    R B Schwartz
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 217:371-6. 2000
    To investigate the clinical parameters that are associated with the development of brain edema of hypertensive encephalopathy in patients with preeclampsia-eclampsia.
  15. ncbi Guidelines for the management of hypertensive disorders of pregnancy 2008
    Sandra A Lowe
    Royal Hospital for Women, Sydney, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 49:242-6. 2009
    ..of severe hypertension, the use of automated blood pressure monitors, the definition of non-proteinuric pre-eclampsia and measuring proteinuria...
  16. ncbi Magnesium for preventing and treating eclampsia: time for international action
    Shirish S Sheth
    2 2 Navjivan Society, Lamington Road, Mumbai 400 008, India
    Lancet 359:1872-3. 2002
  17. doi Risk factors for eclampsia: a population-based study in Washington State, 1987-2007
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Obstet Gynecol 205:553.e1-7. 2011
    We sought to investigate whether previously identified risk factors are associated with eclampsia in a contemporary, heterogeneous cohort of women.
  18. doi Incidence, risk factors, and associated complications of eclampsia
    Shiliang Liu
    Health Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Obstet Gynecol 118:987-94. 2011
    To estimate trends in incidence and identify risk factors and maternal and neonatal consequences of eclampsia in Canada.
  19. ncbi Hospital, simulation center, and teamwork training for eclampsia management: a randomized controlled trial
    Denise Ellis
    Department of Obstetrics and Gynaecology, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom
    Obstet Gynecol 111:723-31. 2008
    To compare the effectiveness of training for eclampsia in local hospitals and a regional simulation center, with and without teamwork theory.
  20. pmc Criteria-based audit on management of eclampsia patients at a tertiary hospital in Dar es Salaam, Tanzania
    Hussein Lesio Kidanto
    Department of Obstetrics and Gynaecology, Muhimbili National Hospital, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 9:13. 2009
    ..study discusses the introduction of a criteria-based audit in a tertiary hospital in an African setting, assesses the quality of care among eclampsia patients and discusses possible interventions in order to improve the quality of care.
  21. ncbi Management of eclampsia at AKTH: before and after magnesium sulphate
    J Tukur
    Department of Obstetrics and Gynaecology, Bayero University, Aminu Kano Teaching Hospital, Kano
    Niger J Med 19:104-7. 2010
    b>Eclampsia contributes significantly to maternal and perinatal morbidity and mortality in Nigeria...
  22. pmc Eclampsia: still a problem in Bangladesh
    Mosammat Rashida Begum
    OB GYN Dhaka Medical College and Hospital, Bangladesh
    MedGenMed 6:52. 2004
    ..Although magnesium sulfate controls convulsion efficiently, death from eclampsia remains high in our country...
  23. pmc Magnesium sulfate for the treatment of eclampsia: a brief review
    Anna G Euser
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1169-75. 2009
    ..This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment...
  24. ncbi An Australian twin study of the genetic basis of preeclampsia and eclampsia
    S A Treloar
    Queensland Institute of Medical Research and the Joint Genetics Program, The University of Queensland, Brisbane, Australia
    Am J Obstet Gynecol 184:374-81. 2001
    OBJECTIVE: We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin ..
  25. ncbi Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004
    Anne B Wallis
    Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Am J Hypertens 21:521-6. 2008
    ..We describe population trends in the incidence rates of preeclampsia, eclampsia, and gestational hypertension in the United States for 1987-2004.
  26. ncbi Magnesium sulphate and other anticonvulsants for women with pre-eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford Institute for Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, UK, BD9 6RJ
    Cochrane Database Syst Rev 11:CD000025. 2010
    b>Eclampsia, the occurrence of a seizure (fit) in association with pre-eclampsia, is rare but potentially life-threatening. Magnesium sulphate is the drug of choice for treating eclampsia...
  27. doi Pre-eclampsia, birth weight, and autism spectrum disorders
    Joshua R Mann
    Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, 29203, USA
    J Autism Dev Disord 40:548-54. 2010
    ..78, p = .001 for each additional kilogram). Maternal pre-eclampsia/eclampsia was significantly associated with greater odds of ASD (OR = 1.85, p < ...
  28. doi 'Padhar regime' - a low-dose magnesium sulphate treatment for eclampsia
    Niraj N Mahajan
    Department of Obstetrics and Gynaecology, Padhar Hospital, Padhar, India
    Gynecol Obstet Invest 67:20-4. 2009
    To determine the recurrent convulsion rate using low-dose magnesium sulphate regime in eclampsia and to identify toxicity and complications with clinical parameters.
  29. pmc Predictors of extra care among magnesium sulphate treated eclamptic patients at Muhimbili National Hospital, Tanzania
    Projestine S Muganyizi
    Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences MUHAS, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 11:41. 2011
    The inclusion of Magnesium Sulphate (MgSO4) as a gold standard in the treatment of eclampsia has substantially reduced incidences of repeated fits, eclamptic morbidity and deaths...
  30. pmc Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control
    Steven J Wagner
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:851-6. 2011
    To assess the prevalence, clinical presentations, and neuroimaging abnormalities in a series of patients treated for eclampsia at Mayo Clinic in Rochester, MN.
  31. ncbi Maternal and fetal outcome of anaesthesia for caesarean delivery in preeclampsia/eclampsia in Enugu, Nigeria: a retrospective observational study
    U V Okafor
    Department of Anaesthesia, University of Nigeria Teaching Hospital, Enugu, Nigeria
    Int J Obstet Anesth 14:108-13. 2005
    ..Accurate data are available for caesarean sections in the University of Nigeria Teaching Hospital, Enugu. We therefore studied the outcome of caesarean section among these high-risk patients...
  32. ncbi Spontaneous bilateral perirenal hematomas in two patients with eclampsia
    Issam M Kably
    Emergency Radiology Department, CHU Ibn Rochd, 20 Lot Mimosas, Bd Ibnou Sina, Casablanca 20100, Morocco
    J Nephrol 16:267-71. 2003
    ..cases of spontaneous and bilateral perirenal hematomas that occurred during a pregnancy complicated by eclampsia. The sonographic and computed tomographic findings included bilateral perirenal hematoma with no evidence of an ..
  33. doi Late postpartum eclampsia
    S Chhabra
    Department of Obstetrics and Gynaecology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India mail com
    J Obstet Gynaecol 32:264-6. 2012
    Studies lack data regarding incidence, risk factors, optimal treatment and outcome of postpartum eclampsia (PPE), convulsions within 7 days (mostly convulsions occur within 24 - 48 h) after delivery of fetus placenta...
  34. pmc Improved quality of management of eclampsia patients through criteria based audit at Muhimbili National Hospital, Dar es Salaam, Tanzania. Bridging the quality gap
    Hussein Lesio Kidanto
    Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 12:134. 2012
    ..This study discusses the use of a CBA to improve quality of care among eclampsia patients admitted at a University teaching hospital in Dar es Salaam Tanzania.
  35. ncbi Eclampsia in advanced abdominal pregnancy
    B A Ekele
    Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    Niger J Clin Pract 10:343-5. 2007
    The occurrence of eclampsia in an extra uterine pregnancy is a very rare entity. We report a case of a patient with eclampsia and advanced extra-uterine pregnancy...
  36. ncbi Posterior reversible leukoencephalopathy in a case of postpartum eclampsia
    Maryam Parisaei
    Department of Obstetrics and Gynaecology, Homerton University Hospital, London, United Kingdom
    Am J Obstet Gynecol 193:885-6. 2005
    This case report describes an atypical presentation of eclampsia. A 26-year-old lady presented 5 days' postpartum with a series of grand mal seizures after an uneventful pregnancy and delivery...
  37. ncbi Ionized and total magnesium concentration in patients with severe preeclampsia-eclampsia undergoing magnesium sulfate therapy
    Bibi Shahnaz Aali
    Department of Obstetrics and Gynecology, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
    J Obstet Gynaecol Res 33:138-43. 2007
    ..the present study was performed to determine the levels and correlations between ionized and total magnesium under baseline and therapeutic conditions in patients with severe preeclampsia and eclampsia receiving magnesium sulfate.
  38. doi Maternal pre-eclampsia is associated with childhood epilepsy in South Carolina children insured by Medicaid
    Joshua R Mann
    Department of Family and Preventive Medicine, University of South Carolina School of Medicine, 3209 Colonial Drive, Columbia, SC 29210, USA
    Epilepsy Behav 20:506-11. 2011
    We examined the association between maternal pre-eclampsia/eclampsia (PE) and childhood epilepsy.
  39. ncbi Advances in the understanding of eclampsia
    S Ananth Karumanchi
    University of Chicago, 5841 South Maryland Avenue, MC 5100, Chicago, IL 60637, USA
    Curr Hypertens Rep 10:305-12. 2008
    ..b>Eclampsia-new-onset seizures in the setting of preeclampsia-usually occurs before or within 48 hours of delivery, but can ..
  40. doi A randomised comparative study between low-dose intravenous magnesium sulphate and standard intramuscular regimen for treatment of eclampsia
    N Bhattacharjee
    Department of Obstetrics and Gynaecology, R G Kar Medical College, Kolkata, India
    J Obstet Gynaecol 31:298-303. 2011
    ..control study, we evaluated the efficacy of intravenous low-dose magnesium sulphate for the management of eclampsia. A total of 144 women with eclampsia were divided into a study group and a control group of 72 women each...
  41. doi Comparison of magnesium sulfate and mannitol in treatment of eclamptic women with posterior reversible encephalopathy syndrome
    Bilge Cetinkaya Demir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Nilufer, 16059 Bursa, Turkey
    Arch Gynecol Obstet 286:287-93. 2012
    ..To evaluate and compare the effectiveness of magnesium sulfate (MgSO(4)) and mannitol in the treatment of posterior reversible encephalopathy syndrome (PRES) in eclamptic women...
  42. ncbi Severe preeclampsia and eclampsia in Kerman, Iran: complications and outcomes
    Bibi Shahnaz Aali
    Kerman University of Medical Sciences and Health Services, Kerman, Iran
    Med Sci Monit 10:CR163-7. 2004
    Our objective was to assess the frequency, epidemiological factors, complications, and outcome of severe preeclampsia and eclampsia and compare them according to severity of the condition in Kerman, southeastern Iran.
  43. ncbi Eclampsia complicated by abdominal compartment syndrome
    Christine E Richter
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Perinatol 26:751-3. 2009
    A primigravida with eclampsia and hemolytic anemia, elevated liver enzymes, and low platelet count (HELLP syndrome) developed intra-abdominal compartment syndrome requiring a decompressive laparotomy, underlining the importance of ..
  44. ncbi Non-aneurysmal primary subarachnoid hemorrhage in pregnancy-induced hypertension and eclampsia
    A K Shah
    Wayne State University Detroit Medical Center, Detroit, MI, USA
    Neurology 61:117-20. 2003
    Clinical as well as neuroimaging studies of women with eclampsia or pregnancy-induced hypertension (PIH) have described a variety of neurologic manifestations, including intraparenchymal brain hemorrhage...
  45. doi The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia
    Jamilu Tukur
    Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital Bayero University, Kano, Nigeria
    Ann Afr Med 8:76-80. 2009
    Pre-eclampsia and eclampsia are important causes of maternal and perinatal morbidity and mortality in the developing countries. There is need to provide the most effective management to pre-eclamptic and eclamptic patients...
  46. ncbi Characteristics of preeclampsia- and eclampsia-related maternal death in rural Haiti
    Maria J Small
    Yale University School of Medicine, Yale University School of Public Health, Division of Maternal Fetal Medicine, New Haven, CT 06520 8063, USA
    J Matern Fetal Neonatal Med 18:343-8. 2005
    ..Preeclampsia- and eclampsia-related complications are one of the leading causes of maternal death...
  47. ncbi Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia
    A H Shaamash
    Department of Obstetrics and Gynecology, Assiut University, Assiut, Egypt
    Int J Gynaecol Obstet 68:207-14. 2000
    To measure the maternal and fetal serum concentrations of total nitrites and nitrates (as an index of nitric oxide production) in normal pregnancy, pre-eclampsia and eclampsia.
  48. ncbi Does human immunodeficiency virus infection protect against preeclampsia-eclampsia?
    K A Frank
    Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Obstet Gynecol 104:238-42. 2004
    ..that human immunodeficiency virus (HIV) infection may protect against preeclampsia, this study was done to evaluate whether untreated HIV-positive pregnant women have a lower rate of preeclampsia-eclampsia than HIV-negative women.
  49. ncbi Evolutionary adaptations to pre-eclampsia/eclampsia in humans: low fecundability rate, loss of oestrus, prohibitions of incest and systematic polyandry
    Pierre Yves Robillard
    Neonatology, Centre Hospitalier Sud Reunion, Saint Pierre Cedex, Reunion, France
    Am J Reprod Immunol 47:104-11. 2002
    Gestational-hypertension/pre-eclampsia occurs in approximately 10% of human pregnancies...
  50. doi Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait
    A E Omu
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 17:227-32. 2008
    To evaluate the outcome of the use of MgSO4 therapy in women with severe pre-eclampsia in Kuwait from January 2002 to December 2004.
  51. ncbi Eclampsia: morbidity, mortality, and management
    Kjersti M Aagaard-Tillery
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Clin Obstet Gynecol 48:12-23. 2005
  52. doi Comparison of intramuscular magnesium sulfate with low dose intravenous magnesium sulfate regimen for treatment of eclampsia
    Joydeb Roy Chowdhury
    Department of Gynecology and Obstetrics, NRS Medical College, Kolkata, West Bengal, India
    J Obstet Gynaecol Res 35:119-25. 2009
    Our objective was to compare intramuscular (i.m.) magnesium sulfate with a low dose intravenous (i.v.) magnesium sulfate regimen in prevention of convulsion recurrence and maternal deaths in women with eclampsia.
  53. doi Brain lesions several years after eclampsia
    Annet M Aukes
    School for Behavioral and Cognitive Neurosciences, University Medical Center Groningen, Groningen, The Netherlands
    Am J Obstet Gynecol 200:504.e1-5. 2009
    b>Eclampsia is thought to have no long-term neurological consequences...
  54. ncbi Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles
    J F Lu
    Department of Clinical Pharmacology, Jingling Hospital, Nanjing, PR China
    Clin Pharmacokinet 38:305-14. 2000
    Magnesium sulfate (MgSO4) is the agent most commonly used for treatment of eclampsia and prophylaxis of eclampsia in patients with severe pre-eclampsia. It is usually given by either the intramuscular or intravenous routes...
  55. ncbi Preeclampsia: increasing incidence but improved outcome?
    Marian Knight
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
    Am J Hypertens 21:491. 2008
  56. ncbi Late postpartum eclampsia: report of two cases managed by uterine curettage and review of the literature
    Koji Matsuo
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Perinatol 24:257-66. 2007
    The purpose of this study was describe two patients with rapid recovery of refractory late postpartum eclampsia (LPPE) following uterine curettage, and to evaluate the literature about supportive evidence for such a management in LPPE...
  57. ncbi Cerebral infarction in eclampsia
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 190:714-20. 2004
    ..This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI)...
  58. ncbi Eclampsia, hippocampal sclerosis, and temporal lobe epilepsy: accident or association?
    N Lawn
    UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, USA
    Neurology 62:1352-6. 2004
    ..Up to 30% of patients with temporal lobe epilepsy (TLE) have no identifiable risk factors...
  59. ncbi Eclampsia and abnormal QTc
    S A Isezuo
    Departments of Medicine, Usman Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    West Afr J Med 23:123-7. 2004
    Abnormalities of calcium and magnesium metabolism are known risk factors for QT interval prolongation and have been reported in eclampsia.
  60. doi Maternal and perinatal outcome of eclampsia in tertiary health institution in Southeast Nigeria
    Echendu Dolly Adinma
    Department of Community Medicine, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
    J Matern Fetal Neonatal Med 26:211-4. 2013
    To evaluate the maternal and perinatal outcome in patients with eclampsia at Nnamdi-Azikiwe-University-Teaching-Hospital (NAUTH), Nnewi, Nigeria.
  61. ncbi The 'Severe Hypertensive Illness in Pregnancy' (SHIP) audit: promoting quality care using a high risk monitoring chart and eclampsia treatment pack
    K Joanne Baldwin
    North Staffordshire Hospital and Keele University, UK
    J Obstet Gynaecol 22:346-52. 2002
    ..Intervention comprised feedback of baseline results to each hospital, a monitoring chart and eclampsia treatment pack...
  62. ncbi Acute renal failure during eclampsia: incidence risks factors and outcome in intensive care unit
    Khalid Mjahed
    Service d Anesthésie réanimation Centrale, CHU Ibn Rochd, Casablanca, Morocco
    Ren Fail 26:215-21. 2004
    To assess the incidence, risk factors and the outcome of acute renal failure (ARF) associated with eclampsia in intensive care unit (ICU).
  63. doi Delayed postpartum preeclampsia and eclampsia: demographics, clinical course, and complications
    Zain Al-Safi
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine Detroit Medical Center, Detroit, Michigan 48201, USA
    Obstet Gynecol 118:1102-7. 2011
    To estimate and evaluate the demographics, clinical course, and complications of delayed postpartum preeclampsia in patients with and without eclampsia.
  64. ncbi Polymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia
    Ayfer Pazarbasi
    Department of Medical Biology and Genetics, University of Cukurova, Faculty of Medicine, Balcali, Adana 01330, Turkey
    Acta Med Okayama 61:153-60. 2007
    The genetic background predisposing pregnant women to pre-eclampsia/eclampsia (PE/E) is still unknown...
  65. ncbi Maternal cigarette smoking and the risk of pregnancy-induced hypertension and eclampsia
    Qiuying Yang
    OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ontario, Canada
    Int J Epidemiol 35:288-93. 2006
    ..No previous study has specifically examined the relationship between maternal smoking and eclampsia.
  66. ncbi Bilateral total loss of vision following eclampsia--a case report
    M J Waziri-Erameh
    Department of Ophthalmology, College of Medical Sciences, University of Benin, Benin City, Nigeria
    Afr J Reprod Health 7:106-8. 2003
    Visual loss following eclampsia is usually reported to be a result of retinopathy, exudative retinal detachment or cortical blindness...
  67. ncbi Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit
    Aliye Esmaoglu
    Department of Anesthesiology and Intensive Care, University of Erciyes, Kayseri, Turkey 38039
    J Crit Care 24:551-5. 2009
    This study compares the effectiveness of midazolam and dexmedetomidine for the sedation of eclampsia patients admitted to our intensive care unit (ICU).
  68. doi Eclampsia: a neurological perspective
    A K Shah
    Department of Neurology, Wayne State University Detroit Medical Center, Detroit, MI 48201, United States
    J Neurol Sci 271:158-67. 2008
    b>Eclampsia is a poorly understood disorder characterized by seizures or unexplained coma in setting of gestational hypertension...
  69. ncbi Strategies to prevent eclampsia in a developing country: II. Use of a maternal pictorial card
    I MacGillivray
    Institute of Child Health, University of Bristol, UK
    Int J Gynaecol Obstet 87:295-300. 2004
    To assess the efficacy and acceptability of a patient-held pictorial card aimed at raising awareness and appropriate health seeking behavior in response to prodromal symptoms of imminent eclampsia.
  70. ncbi Use of magnesium sulfate in pre-eclampsia and eclampsia in teaching hospitals in Addis Ababa: a practice audit
    Workineh Getaneh
    Department of Obstetrics and Gynecology, AAU, MF
    Ethiop Med J 48:157-64. 2010
    Magnesium sulphate is shown to be the drug of choice in the management of severe pre-eclampsia-eclampsia for over two decades. However, the drug was introduced in practice in teaching hospitals in Addis Ababa recently...
  71. doi Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan
    Chao Hsiun Tang
    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
    Stroke 40:1162-8. 2009
    The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations...
  72. pmc Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia
    Marilyn J Cipolla
    Department of Neurology, Univ of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    J Appl Physiol (1985) 110:329-39. 2011
    The cerebral circulation has a central role in mediating the neurological complications of eclampsia, yet our understanding of how pregnancy and preeclampsia affect this circulation is severely limited...
  73. doi Implementing safe motherhood: a low-cost intervention to improve the management of eclampsia in a referral hospital in Malawi
    E Drost
    University Medical Centre Groningen, Department of Obstetrics and Gynaecology, Groningen, The Netherlands
    BJOG 117:1553-7. 2010
    We evaluated the effect of so-called monitoring and treatment charts on the management of eclampsia in a referral hospital in Malawi...
  74. doi The visually-evoked cerebral blood flow response in women with a recent history of preeclampsia and/or eclampsia
    E G H J Martens
    Department of Clinical Neurophysiology, University Hospital Maastricht, Maastricht, The Netherlands
    Ultrasound Med Biol 35:1-7. 2009
    Several studies provide evidence for altered cerebral hemodynamics during (pre)eclampsia. Whether (pre)eclampsia has a persistent negative impact on cerebral hemodynamics, possibly contributing to an elevated risk of premature stroke, is ..
  75. ncbi Neurocysticercosis in pregnancy: a case initially diagnosed as eclampsia
    V R Suarez
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois 60153 3304, USA
    Obstet Gynecol 93:816-8. 1999
    ..Neurocysticercosis is an infection of the central nervous system with the pork tapeworm's cysticercus...
  76. ncbi Strategies to prevent eclampsia in a developing country: I. Reorganization of maternity services
    A M McCaw-Binns
    Department of Community Health and Psychiatry, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies, Jamaica
    Int J Gynaecol Obstet 87:286-94. 2004
    To determine whether changes in primary and secondary care service delivery could prevent antenatal eclampsia.
  77. ncbi The -56T HLA-G promoter polymorphism is not associated with pre-eclampsia/eclampsia in Australian and New Zealand women
    Vicki L Doherty
    Department of Perinatal Medicine, The Royal Women s Hospital, Carlton, Victoria, Australia
    Hypertens Pregnancy 25:63-71. 2006
    ..The aim of this study was to determine whether a C-to-T base substitution 56 base pairs (bp) upstream from the HLA-G transcription start site is associated with preeclampsia...
  78. ncbi No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population
    Meral Cetin
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey
    J Obstet Gynaecol Res 31:236-41. 2005
    There is substantial evidence that genetic factors play a role in pre-eclampsia. The aim of this study was to determine whether genetic variability in the encoding of genes for glutathione S-transferase M1 (GSTM1) and glutathione S-..
  79. doi Reversible posterior encephalopathy syndrome followed by MR angiography-documented cerebral vasospasm in preeclampsia-eclampsia: report of 2 cases
    Kiyomi Tsukimori
    Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cerebrovasc Dis 25:377-80. 2008
  80. doi Diagnosis and management of atypical preeclampsia-eclampsia
    Baha M Sibai
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0526, USA
    Am J Obstet Gynecol 200:481.e1-7. 2009
    Preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelets syndrome are major obstetric disorders that are associated with substantial maternal and perinatal morbidities...
  81. doi A 5-year review of maternal mortality associated with eclampsia in a tertiary institution in northern Nigeria
    Abubakar Ali Kullima
    Department of Obstetrics and Gynaecology, Federal Medical Centre Nguru, Nigeria
    Ann Afr Med 8:81-4. 2009
    To determine the incidence of maternal mortality associated with eclampsia and to determine how socio-demographic and clinical characteristics of the women influence the deaths.
  82. ncbi Methyldopa versus no drug treatment in the management of mild pre-eclampsia
    E M Elhassan
    Department of Obstetrics and Gynaecology, University of Gezira, Sudan
    East Afr Med J 79:172-5. 2002
    To evaluate the efficacy of methyldopa in the treatment of mild pre-eclampsia, to prevent its progress and to investigate its effect on the pregnancy outcomes.
  83. ncbi Diffusion-weighted imaging shows cytotoxic and vasogenic edema in eclampsia
    S Koch
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33136, USA
    AJNR Am J Neuroradiol 22:1068-70. 2001
    In eclampsia, MR imaging shows reversible T2 hyperintensities in a parietal and occipital distribution. Findings on diffusion-weighted images suggest that these abnormalities are areas of vasogenic edema...
  84. ncbi Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia
    Bunyamin Borekci
    Department of Obstetrics and Gynecology, Ataturk University School of Medicine, Erzurum, Turkey
    Am J Reprod Immunol 58:56-64. 2007
    The aim of the study was to investigate and compare the concentrations of interleukin (IL)-2, IL-6, and IL-10 in serum of women with mild pre-eclampsia, severe pre-eclampsia, eclampsia, and normotensive pregnancy.
  85. pmc Seasonal variation in the incidence of preeclampsia and eclampsia in tropical climatic conditions
    Vidya Subramaniam
    Department of Obstetrics and Gynaecology, Bassetlaw Hospital, Blyth Road, Worksop, Nottinghamshire, UK
    BMC Womens Health 7:18. 2007
    ..We aim to study if a correlation exists between the incidence of eclampsia and pre-eclampsia and various weather parameters in the tropical coastal city of Mumbai which has the ..
  86. pmc System and market failures: the unavailability of magnesium sulphate for the treatment of eclampsia and pre-eclampsia in Mozambique and Zimbabwe
    E Sevene
    Department of Pharmacology, Faculty of Medicine, Eduardo Mondlane University, Mozambique
    BMJ 331:765-9. 2005
  87. ncbi Why much of the pathophysiology of preeclampsia-eclampsia must be of an autoimmune nature
    Norbert Gleicher
    Center for Human Reproduction, New York, NY, USA
    Am J Obstet Gynecol 196:5.e1-7. 2007
    Preeclampsia-eclampsia (PE-E) is a poorly understood condition of human pregnancy, which can affect multiple organs and is a leading cause of maternal deaths worldwide...
  88. ncbi Maternal and fetal outcome in eclamptic patients in Benin City, Nigeria
    S O Onuh
    Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    J Obstet Gynaecol 24:765-8. 2004
    b>Eclampsia is a well-recognised major cause of maternal death and perinatal morbidity and mortality...
  89. ncbi Late postpartum eclampsia: examples and review
    Jennifer Hirshfeld-Cytron
    Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA
    Obstet Gynecol Surv 61:471-80. 2006
    b>Eclampsia, defined as the occurrence of seizures in pregnant women, usually in the setting of preeclampsia and in the absence of other neurologic disorders, occurs mainly before, during , or within 48 hours after delivery...
  90. ncbi The Diabetes and Pre-eclampsia Intervention Trial
    V A Holmes
    Department of Medicine, Queen s University Belfast, Belfast, UK
    Int J Gynaecol Obstet 87:66-71. 2004
    Rates of pre-eclampsia in women with type 1 diabetes are two to four times higher than in normal pregnancies...
  91. ncbi A case of hyperreactio luteinalis presenting with eclampsia
    D K Gatongi
    Department of Obstetrics and Gynaecology, Ninewells Hospital, Dundee, UK
    J Obstet Gynaecol 26:465-7. 2006
  92. ncbi Imitators of severe pre-eclampsia/eclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0526, Cincinnati, OH 45267 0526, USA
    Clin Perinatol 31:835-52, vii-viii. 2004
    ..Severe pre-eclampsia with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and many other obstetric and medical ..
  93. ncbi Epidemiology of pre-eclampsia and eclampsia at the KK Women's and Children's Hospital, Singapore
    K H Tan
    Department of Maternal Foetal Medicine, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore 229899
    Singapore Med J 47:48-53. 2006
    The incidences and characteristics of pre-eclampsia (PE) and eclampsia in KK Women's and Children's Hospital (KKH), a tertiary obstetrical referral centre in Singapore, were studied.
  94. ncbi T594M mutation of the epithelial sodium channel beta-subunit gene in pre-eclampsia and eclampsia in Black South African women
    R J Pegoraro
    Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Congella 4013, Durban, South Africa
    BJOG 111:1012-3. 2004
    ..This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 ..
  95. ncbi Pregnancy prevents hypertensive remodeling of cerebral arteries: a potential role in the development of eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Hypertension 47:619-26. 2006
    ..elevated blood pressure, these results suggest that hypertension in pregnancy may predispose the cerebral circulation to autoregulatory breakthrough and blood-brain-barrier disruption when blood pressure is elevated, as during eclampsia.
  96. ncbi Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure
    James N Martin
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Obstet Gynecol 105:246-54. 2005
    To identify important clinical correlates of stroke in patients with preeclampsia and eclampsia.
  97. ncbi Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome
    Ahmet Gul
    Maternal and Fetal Unit, Istanbul SSK Bakirkoy Women and Children Hospital, Istanbul, Turkey
    Gynecol Obstet Invest 59:113-8. 2005
    Our purpose was to find out and compare perinatal outcomes in pregnancies complicated by severe preeclampsia-eclampsia with and without HELLP syndrome.
  98. ncbi Safety and efficacy of low-dose MgSO4 in the treatment of eclampsia
    - Shilva
    Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Int J Gynaecol Obstet 97:150-1. 2007
  99. ncbi Descriptive and clinical epidemiology of preeclampsia and eclampsia in Florida
    Zuber D Mulla
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, El Paso, Texas 79905, USA
    Ethn Dis 17:736-41. 2007
    To calculate preeclampsia/eclampsia rates for Florida and identify risk factors for prolonged length of stay (PLOS) among women hospitalized throughout Florida for preeclampsia/eclampsia and discharged in 2001.
  100. pmc A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q
    G A Harrison
    School of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia
    Am J Hum Genet 60:1158-67. 1997
    Preeclampsia (PE) and eclampsia (E) are potentially life-threatening conditions that can occur during human pregnancy...
  101. doi Reducing eclampsia-related deaths--a call to action
    Ana Langer
    EngenderHealth, New York, NY 10001, USA
    Lancet 371:705-6. 2008

Research Grants74

  1. CANCER IN THE JERUSALEM PERINATAL STUDY COHORT
    Susan Harlap; Fiscal Year: 1999
    ..defects, including neural tube defects and Down's syndrome, or by certain obstetric outcomes, including pre-eclampsia. The results may identify women who would benefit from intensive screening or provide new clues to the etiology ..
  2. CANCER IN THE JERUSALEM PERINATAL STUDY COHORT
    Susan Harlap; Fiscal Year: 2001
    ..defects, including neural tube defects and Down's syndrome, or by certain obstetric outcomes, including pre-eclampsia. The results may identify women who would benefit from intensive screening or provide new clues to the etiology ..
  3. CANCER IN THE JERUSALEM PERINATAL STUDY COHORT
    Susan Harlap; Fiscal Year: 2002
    ..defects, including neural tube defects and Down's syndrome, or by certain obstetric outcomes, including pre-eclampsia. The results may identify women who would benefit from intensive screening or provide new clues to the etiology ..
  4. CANCER IN THE JERUSALEM PERINATAL STUDY COHORT
    Susan Harlap; Fiscal Year: 2000
    ..defects, including neural tube defects and Down's syndrome, or by certain obstetric outcomes, including pre-eclampsia. The results may identify women who would benefit from intensive screening or provide new clues to the etiology ..
  5. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..is rapidly becoming a major obstetric complication since it increases the risk of gestational diabetes and pre-eclampsia, and predisposes the mother for later metabolic and cardiovascular disease...
  6. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..is rapidly becoming a major obstetric complication since it increases the risk of gestational diabetes and pre-eclampsia, and predisposes the mother for later metabolic and cardiovascular disease...
  7. Development of a Yoga Intervention for Antenatal Depression
    Cynthia L Battle; Fiscal Year: 2010
    ..Antenatal depression is linked to many adverse outcomes, including higher rates of spontaneous abortion, pre-eclampsia, operative delivery, postpartum depression, neonatal growth retardation, pre-term delivery, low birth weight, ..
  8. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    RICHARD LEGRO; Fiscal Year: 2009
    ..and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia. PCOS results in a significant health care burden to our economy with an estimated $500 million spent annually ..
  9. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2010
    ..and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia. PCOS results in a significant health care burden to our economy with an estimated $500 million spent annually ..
  10. Weight management for improved pregnancy outcomes
    Victor Stevens; Fiscal Year: 2009
    ..serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes, pre-eclampsia, or cesarean delivery, the best strategy during their pregnancy may be to maintain a steady weight rather than ..
  11. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2010
    ..serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes, pre-eclampsia, or cesarean delivery, the best strategy during their pregnancy may be to maintain a steady weight rather than ..
  12. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..Hypertension may lead to pre-eclampsia, which can restrict fetal growth or trigger premature birth...
  13. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE O BRIEN; Fiscal Year: 2009
    ..Hypertension may lead to pre-eclampsia, which can restrict fetal growth or trigger premature birth...
  14. Oklahoma Center on American Indian Diabetes Health Disparities
    Joseph Henderson; Fiscal Year: 2007
    ..Full Proposal topics are 1) Early Markers of Pre-eclampsia in American Indians with Type 2 Diabetes, 2) Insulin Resistance and Glucocorticoid Treatment of Inflammatory ..
  15. Oklahoma Center on American Indian Diabetes Health Disparities
    Joseph Henderson; Fiscal Year: 2009
    ..Full Proposal topics are 1) Early Markers of Pre-eclampsia in American Indians with Type 2 Diabetes, 2) Insulin Resistance and Glucocorticoid Treatment of Inflammatory ..
  16. Oklahoma Center on American Indian Diabetes Health Disparities
    JOSEPH NEIL HENDERSON; Fiscal Year: 2010
    ..Full Proposal topics are 1) Early Markers of Pre-eclampsia in American Indians with Type 2 Diabetes, 2) Insulin Resistance and Glucocorticoid Treatment of Inflammatory ..
  17. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..and fetal mortality and morbidity are threatened by the hypertension, proteinuria and pathological edema of pre-eclampsia. Studies are proposed that will further define mechanisms responsible for the control of atrial natriuretic ..
  18. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 1999
    ..and fetal mortality and morbidity are threatened by the hypertension, proteinuria and pathological edema of pre-eclampsia. Studies are proposed that will further define mechanisms responsible for the control of atrial natriuretic ..
  19. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..resistance or how NO may buffer vasoconstriction and that a defect in NO production may be involved in pre-eclampsia. Despite increasing evidence that NO also modulates mitochondrial metabolism and substrate uptake by the heart, ..
  20. Nitric Oxide Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2003
    ..resistance or how NO may buffer vasoconstriction and that a defect in NO production may be involved in pre-eclampsia. Despite increasing evidence that NO also modulates mitochondrial metabolism and substrate uptake by the heart, ..
  21. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
    ..feature of a healthy pregnancy, shallow invasion is associated with placental pathologies, among them pre-eclampsia (PE) and intra-uterine growth retardation (IUGR)...
  22. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    ..The relation of maternal vitamin D status to important complications of pregnancy (gestational diabetes and pre-eclampsia). 3...
  23. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2010
    ..serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes, pre-eclampsia, or cesarean delivery, the best strategy during their pregnancy may be to maintain a steady weight rather than ..
  24. Gonadal Peptide Effect on Female Reproduction--Activins
    YU WAI LIN; Fiscal Year: 2003
    ..of inhibin B are associated with granulosa cell carcinoma, and high levels of inhibin A are correlated with pre-eclampsia and Down syndrome during pregnancy...
  25. FETAL ERYTHROID CELLS IN MATERNAL CIRCULATION
    STEPHEN GRANT; Fiscal Year: 1999
    ..will then be applied to incident maternal/fetal pairs with a variety of adverse outcomes, including pre- eclampsia. This study will also provide samples for the development and application of techniques for fetal cell ..
  26. THE PHYSIOLOGY OF PLACENTAL LACTOGEN
    Stuart Handwerger; Fiscal Year: 2000
    ..since abnormal plasma hPL concentrations have been noted in many pathologic conditions of pregnancy, such as pre-eclampsia, diabetes mellitus and other disorders associated with intrauterine growth retardation and fetal morbidity...
  27. THE PHYSIOLOGY OF PLACENTAL LACTOGEN
    Stuart Handwerger; Fiscal Year: 1999
    ..since abnormal plasma hPL concentrations have been noted in many pathologic conditions of pregnancy, such as pre-eclampsia, diabetes mellitus and other disorders associated with intrauterine growth retardation and fetal morbidity...
  28. Prepregnancy Phenotype & Predisposition to Pre-eclampsia
    Ira Bernstein; Fiscal Year: 2004
    ..We have generated a novel hypothesis regarding the development of pre-eclampsia that postulates that two primary features contribute independently to its development...
  29. Prepregnancy Phenotype & Predisposition to Pre-eclampsia
    Ira Bernstein; Fiscal Year: 2006
    ..We have generated a novel hypothesis regarding the development of pre-eclampsia that postulates that two primary features contribute independently to its development...
  30. Prepregnancy Phenotype & Predisposition to Pre-eclampsia
    Ira Bernstein; Fiscal Year: 2007
    ..We have generated a novel hypothesis regarding the development of pre-eclampsia that postulates that two primary features contribute independently to its development...
  31. Prepregnancy Phenotype & Predisposition to Pre-eclampsia
    Ira Bernstein; Fiscal Year: 2005
    ..We have generated a novel hypothesis regarding the development of pre-eclampsia that postulates that two primary features contribute independently to its development...
  32. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..of placental HCMV infection, including first trimester pregnancy loss, intrauterine growth restriction, pre-eclampsia and preterm labor, are believed to be mediated by the inability of extravillous cytotrophoblasts (EVT) to ..
  33. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..of placental HCMV infection, including first trimester pregnancy loss, intrauterine growth restriction, pre-eclampsia and preterm labor, are believed to be mediated by the inability of extravillous cytotrophoblasts (EVT) to ..
  34. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2010
    ..of placental HCMV infection, including first trimester pregnancy loss, intrauterine growth restriction, pre-eclampsia and preterm labor, are believed to be mediated by the inability of extravillous cytotrophoblasts (EVT) to ..
  35. Target regulation of neuronal plasticity
    Keith Crutcher; Fiscal Year: 2007
    ..Failure of this "natural" plasticity occurs in pathological situations such as pre-eclampsia, which can be fatal to both mother and fetus...
  36. Target regulation of neuronal plasticity
    David Pettigrew; Fiscal Year: 2009
    ..Failure of this "natural" plasticity occurs in pathological situations such as pre-eclampsia, which can be fatal to both mother and fetus...
  37. GLOMERULAR INJURY OF PRE-ECLAMPSIA
    Bryan Myers; Fiscal Year: 2000
    This proposal seeks to elucidate the pathophysiology of and evaluate novel therapy for pre-eclampsia toxemia (PET). This pregnancy-induced disease represents the commonest form of injury to glomerular endothelial cells in humans...
  38. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2001
    ..macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia. To accomplish this, the investigators propose to conduct five nested case-control studies, one for each of the ..
  39. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2002
    ..g., sleep apnea, rheumatoid arthritis, pre-eclampsia, multiple sclerosis...
  40. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2003
    ..g., sleep apnea, rheumatoid arthritis, pre-eclampsia, multiple sclerosis...
  41. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2001
    ..g., sleep apnea, rheumatoid arthritis, pre-eclampsia, multiple sclerosis...
  42. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2004
    ..g., sleep apnea, rheumatoid arthritis, pre-eclampsia, multiple sclerosis...
  43. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2003
    b>Eclampsia is a serious complication of pregnancy that occurs when hypertension develops with neurologic symptoms, including headaches, nausea, visual disturbances and convulsions...
  44. The Role of Leptin in Placental Development
    Laura Schulz; Fiscal Year: 2009
    ..First, insufficient trophoblast invasion is associated with pre-eclampsia, the most common complication of pregnancy, and one which can be fatal...
  45. ORAL CALCIUM IN PREGNANT WOMEN WITH CHRONIC HYPERTENSION
    Phyllis August; Fiscal Year: 1993
    ..lower blood pressure, b) reduce the need for antihypertensive drugs, and c) reduce the incidence of preeclampsia/eclampsia in pregnant women with chronic hypertension...
  46. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    ..neonate, but also on pregnancy outcome, including spontaneous abortion, intrauterine growth restriction and pre-eclampsia. Despite the significant morbidity and mortality associated with congenital CMV infection, little is known about ..
  47. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2004
    ..neonate, but also on pregnancy outcome, including spontaneous abortion, intrauterine growth restriction and pre-eclampsia. Despite the significant morbidity and mortality associated with congenital CMV infection, little is known about ..
  48. Effects of Statins on Heme Oxygenase-1 Regulation
    David Stevenson; Fiscal Year: 2007
    ..Moreover, a reduced level of placental HO-1 seems to be associated with a higher risk for pre-eclampsia. Thus, therapeutic strategies aimed at moderately increasing tissue expression of HO-1 might be beneficial in a ..
  49. Adenosine signaling protects the glomerular endothelium
    David J Friedman; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: In diseases such as pre-eclampsia or complications of some cancer therapies, the kidney is injured by lack of important growth factors...
  50. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2005
    ..neonate, but also on pregnancy outcome, including spontaneous abortion, intrauterine growth restriction and pre-eclampsia. Despite the significant morbidity and mortality associated with congenital CMV infection, little is known about ..
  51. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    JOHN NESTLER; Fiscal Year: 2009
    ..covered by training mentors, including polycystic ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea vaccine development, steroidogenesis, and promotion of ..
  52. Decidual Fibroblast Differntiation and Human Implantation
    Linda Giudice; Fiscal Year: 2007
    ..can lead to miscarriage, infertility, and pregnancy disorders, including fetal growth restriction and pre-eclampsia. Successful implantation requires estradiol (E2)-induced endometrial cellular growth and progesterone (P)- ..
  53. PERINATAL FACTORS AND BREAST CANCER
    Dimitrios Trichopoulos; Fiscal Year: 2000
    ..of fetal size; to confirm the negative association between breast cancer risk and maternal eclampsial pre-eclampsia; to examine the observed positive association between breast cancer risk and prematurity and neonatal jaundice; ..
  54. Decidual Fibroblast Differentiation and Human Implantation
    Linda Giudice; Fiscal Year: 2009
    ..can lead to miscarriage, infertility, and pregnancy disorders, including fetal growth restriction and pre-eclampsia. Successful implantation requires estradiol (E2)-induced endometrial cellular growth and progesterone (P)- ..
  55. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2002
    ..in the first trimester, is associated with significant complications of pregnancy, including miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR)...
  56. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..the mother's kidneys, liver and other vital organs and, if undetected or untreated, can lead to seizures (eclampsia), cerebral hemorrhage, failure in vital organs (i.e., kidney and heart) and death...
  57. Research Training in Epigenetics of Premature Labor, Progresterone Receptor Expre
    JOHN NESTLER; Fiscal Year: 2007
    ..covered by training mentors, including polycystic ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea vaccine development, steroidogenesis, and promotion of ..
  58. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2003
    ..in the first trimester, is associated with significant complications of pregnancy, including miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR)...
  59. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2004
    ..in the first trimester, is associated with significant complications of pregnancy, including miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR)...
  60. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2006
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  61. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2004
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  62. EFFECTS OF ASTHMA SEVERITY AND MEDICATION IN PREGNANCY
    Michael Bracken; Fiscal Year: 1999
    ..Secondary outcomes are gestational hypertension, pre eclampsia and spontaneous abortion...
  63. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2000
    ..macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia. To accomplish this, the investigators propose to conduct five nested case-control studies, one for each of the ..
  64. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2005
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  65. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2003
    ..macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia. To accomplish this, the investigators propose to conduct five nested case-control studies, one for each of the ..
  66. EFFECTS OF ASTHMA SEVERITY AND MEDICATION IN PREGNANCY
    Michael Bracken; Fiscal Year: 2000
    ..Secondary outcomes are gestational hypertension, pre eclampsia and spontaneous abortion...
  67. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2001
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  68. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2002
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  69. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2002
    ..macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia. To accomplish this, the investigators propose to conduct five nested case-control studies, one for each of the ..
  70. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2003
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  71. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..intervention or prevention of abnormalities in trophoblast invasion, including infertility, ectopic pregnancy, and pre-eclampsia. The investigators work with the human model because of the uniqueness of implantation in humans.
  72. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2007
    A current hypothesis for the etiology of pre-eclampsia is that endothelial dysfunction is secondary to oxidative stress and some clinical studies have indicated that prophylactic administration of anti-oxidants may be useful in its ..
  73. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2002
    ..intervention or prevention of abnormalities in trophoblast invasion, including infertility, ectopic pregnancy, and pre-eclampsia. The investigators work with the human model because of the uniqueness of implantation in humans.
  74. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2005
    ..intervention or prevention of abnormalities in trophoblast invasion, including infertility, ectopic pregnancy, and pre-eclampsia. The investigators work with the human model because of the uniqueness of implantation in humans.