eclampsia

Summary

Summary: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Top Publications

  1. ncbi Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy
    R B Schwartz
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 217:371-6. 2000
  2. ncbi The global impact of pre-eclampsia and eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford, UK
    Semin Perinatol 33:130-7. 2009
  3. ncbi Maternal mortality from preeclampsia/eclampsia
    Labib Ghulmiyyah
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Semin Perinatol 36:56-9. 2012
  4. ncbi Pregnancy-related mortality from preeclampsia and eclampsia
    A P MacKay
    Office of Analysis, Epidemiology, and Health Promotion, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA
    Obstet Gynecol 97:533-8. 2001
  5. ncbi Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre, Groningen, Netherlands
    Lancet 374:979-88. 2009
  6. ncbi Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles
    J F Lu
    Department of Clinical Pharmacology, Jingling Hospital, Nanjing, PR China
    Clin Pharmacokinet 38:305-14. 2000
  7. ncbi Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004
    Anne B Wallis
    Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Am J Hypertens 21:521-6. 2008
  8. ncbi Late postpartum eclampsia: a preventable disease?
    Mark C Chames
    Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, OH, USA
    Am J Obstet Gynecol 186:1174-7. 2002
  9. ncbi Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Am Heart J 156:918-30. 2008
  10. ncbi ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists
    Barrett M Schroeder
    Am Fam Physician 66:330-1. 2002

Detail Information

Publications318 found, 100 shown here

  1. ncbi Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy
    R B Schwartz
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 217:371-6. 2000
    To investigate the clinical parameters that are associated with the development of brain edema of hypertensive encephalopathy in patients with preeclampsia-eclampsia.
  2. ncbi The global impact of pre-eclampsia and eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford, UK
    Semin Perinatol 33:130-7. 2009
    ..Overall, 10% to 15% of direct maternal deaths are associated with preeclampsia and eclampsia. Where maternal mortality is high, most of deaths are attributable to eclampsia, rather than preeclampsia...
  3. ncbi Maternal mortality from preeclampsia/eclampsia
    Labib Ghulmiyyah
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Semin Perinatol 36:56-9. 2012
    Preeclampsia/eclampsia is one of the 3 leading causes of maternal morbidity and mortality worldwide...
  4. ncbi Pregnancy-related mortality from preeclampsia and eclampsia
    A P MacKay
    Office of Analysis, Epidemiology, and Health Promotion, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA
    Obstet Gynecol 97:533-8. 2001
    To examine the role of preeclampsia and eclampsia in pregnancy-related mortality.
  5. ncbi Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre, Groningen, Netherlands
    Lancet 374:979-88. 2009
    ..We investigated whether induction of labour in women with a singleton pregnancy complicated by gestational hypertension or mild pre-eclampsia reduces severe maternal morbidity.
  6. ncbi Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles
    J F Lu
    Department of Clinical Pharmacology, Jingling Hospital, Nanjing, PR China
    Clin Pharmacokinet 38:305-14. 2000
    Magnesium sulfate (MgSO4) is the agent most commonly used for treatment of eclampsia and prophylaxis of eclampsia in patients with severe pre-eclampsia. It is usually given by either the intramuscular or intravenous routes...
  7. ncbi Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004
    Anne B Wallis
    Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Am J Hypertens 21:521-6. 2008
    ..We describe population trends in the incidence rates of preeclampsia, eclampsia, and gestational hypertension in the United States for 1987-2004.
  8. ncbi Late postpartum eclampsia: a preventable disease?
    Mark C Chames
    Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, OH, USA
    Am J Obstet Gynecol 186:1174-7. 2002
    The purpose of this study was to determine whether there is a shift in the timing of eclampsia in relation to delivery and whether traditional symptoms precede impending postpartum eclampsia.
  9. ncbi Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Am Heart J 156:918-30. 2008
    Preeclampsia affects 3% to 5% of gestations and eclampsia 0.05% to 0.93%, but their subsequent cardiovascular sequelae are unclear...
  10. ncbi ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists
    Barrett M Schroeder
    Am Fam Physician 66:330-1. 2002
  11. pmc Factors associated with persistent hypertension after puerperium among women with pre-eclampsia/eclampsia in Mulago hospital, Uganda
    Emmanuel B Ndayambagye
    Department of Obstetrics and Gynecology, Makerere University Medical School, PO Box 7072, Kampala, Uganda
    BMC Pregnancy Childbirth 10:12. 2010
    Women with severe pre-eclampsia/eclampsia are at risk of developing chronic hypertension in future. Chronic hypertension may manifest initially as persistent hypertension at the end of the puerperium...
  12. pmc Magnesium sulfate for the treatment of eclampsia: a brief review
    Anna G Euser
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1169-75. 2009
    ..This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment...
  13. ncbi Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries
    Robert L Goldenberg
    Drexel University College of Medicine, PA19102, USA
    Int J Gynaecol Obstet 113:91-5. 2011
    To evaluate pre-eclampsia/eclampsia-associated maternal mortality in high-income countries to understand better the potential improvements in pre-eclampsia/eclampsia-related mortality in low-income countries.
  14. ncbi Does human immunodeficiency virus infection protect against preeclampsia-eclampsia?
    K A Frank
    Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Obstet Gynecol 104:238-42. 2004
    ..that human immunodeficiency virus (HIV) infection may protect against preeclampsia, this study was done to evaluate whether untreated HIV-positive pregnant women have a lower rate of preeclampsia-eclampsia than HIV-negative women.
  15. ncbi Global and regional estimates of preeclampsia and eclampsia: a systematic review
    Edgardo Abalos
    Centro Rosarino de Estudios Perinatales, Moreno 878, P6, 2000 Rosario, Argentina Electronic address
    Eur J Obstet Gynecol Reprod Biol 170:1-7. 2013
    ..Data on the incidence of preeclampsia and eclampsia, one of the main causes of maternal deaths, are required at both national and regional levels to inform policies...
  16. ncbi Cerebrovascular function in pregnancy and eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hypertension 50:14-24. 2007
  17. ncbi Outcomes of severe pre-eclampsia/eclampsia in Yorkshire 1999/2003
    D J Tuffnell
    Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
    BJOG 112:875-80. 2005
    To establish the risk of serious complications from severe pre-eclampsia and eclampsia in a region using a common guideline for the management of these conditions.
  18. ncbi Magnesium sulfate therapy in preeclampsia and eclampsia
    A G Witlin
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555 0587, USA
    Obstet Gynecol 92:883-9. 1998
    To review the available evidence regarding efficacy, benefits, and risks of magnesium sulfate seizure prophylaxis in women with preeclampsia or eclampsia.
  19. pmc Identifying barriers to the availability and use of Magnesium Sulphate Injection in resource poor countries: a case study in Zambia
    Anna L Ridge
    Medicine Access and Rational Use, Department of Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland
    BMC Health Serv Res 10:340. 2010
    Pre-eclampsia and eclampsia are serious complications of pregnancy and major causes of maternal mortality and morbidity worldwide...
  20. ncbi Eclampsia in the United Kingdom 2005
    M Knight
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
    BJOG 114:1072-8. 2007
    To estimate the national incidence of eclampsia in the UK and to describe the management and associated outcomes since the introduction of magnesium sulphate.
  21. ncbi Stroke in pregnant and postpartum women
    Evgeny V Sidorov
    Beth Israel Deaconess Medical Centre, Boston, MA, USA
    Expert Rev Cardiovasc Ther 9:1235-47. 2011
    ..and are etiologically related to three conditions: reversible cerebral vasoconstriction syndrome, preeclampsia/eclampsia and cerebral venous thrombosis...
  22. ncbi Ionized and total magnesium concentration in patients with severe preeclampsia-eclampsia undergoing magnesium sulfate therapy
    Bibi Shahnaz Aali
    Department of Obstetrics and Gynecology, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
    J Obstet Gynaecol Res 33:138-43. 2007
    ..the present study was performed to determine the levels and correlations between ionized and total magnesium under baseline and therapeutic conditions in patients with severe preeclampsia and eclampsia receiving magnesium sulfate.
  23. ncbi Magnesium sulphate in management of severe pre-eclampsia and eclampsia
    G Dhakal
    National Academy for Medical Sciences, Purano Baneswar, Kathmandu
    J Nepal Health Res Counc 10:113-7. 2012
    Pre-eclampsia and eclampsia (PE/E) are the second leading cause of maternal mortality in Nepal accounting for 21% of all maternal deaths and 30% of all facility based maternal deaths...
  24. ncbi Cerebral infarction in eclampsia
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 190:714-20. 2004
    ..This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI)...
  25. ncbi Role of proteinuria in defining pre-eclampsia: clinical outcomes for women and babies
    Charlene E Thornton
    School of Medicine, University of Western Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 37:466-70. 2010
    1. The presence of proteinuria is not essential to the diagnosis of pre-eclampsia under many diagnostic consensus statements...
  26. ncbi Elevated plasma homocysteine concentrations in severe preeclampsia and eclampsia
    Metin Ingec
    Department of Obstetrics and Gynecology, Ataturk University School of Medicine, Erzurum, Turkey
    Tohoku J Exp Med 206:225-31. 2005
    ..7 +/- 10.1 micromol/l, mean +/- S.D., n = 25) and eclampsia (16.5 +/- 9.6 micromol/l, mean +/- S.D., n = 16) were significantly higher than those in mild preeclampsia (7...
  27. ncbi Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait
    A E Omu
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 17:227-32. 2008
    To evaluate the outcome of the use of MgSO4 therapy in women with severe pre-eclampsia in Kuwait from January 2002 to December 2004.
  28. ncbi 'Padhar regime' - a low-dose magnesium sulphate treatment for eclampsia
    Niraj N Mahajan
    Department of Obstetrics and Gynaecology, Padhar Hospital, Padhar, India
    Gynecol Obstet Invest 67:20-4. 2009
    To determine the recurrent convulsion rate using low-dose magnesium sulphate regime in eclampsia and to identify toxicity and complications with clinical parameters.
  29. ncbi A randomised comparative study between low-dose intravenous magnesium sulphate and standard intramuscular regimen for treatment of eclampsia
    N Bhattacharjee
    Department of Obstetrics and Gynaecology, R G Kar Medical College, Kolkata, India
    J Obstet Gynaecol 31:298-303. 2011
    ..control study, we evaluated the efficacy of intravenous low-dose magnesium sulphate for the management of eclampsia. A total of 144 women with eclampsia were divided into a study group and a control group of 72 women each...
  30. ncbi Risk factors of eclampsia other than hypertension: pregnancy-induced antithrombin deficiency and extraordinary weight gain
    Takashi Yamada
    Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertens Pregnancy 31:268-77. 2012
    ..findings suggest that cerebral edema is a characteristic finding on magnetic resonance imaging in women with eclampsia and that pregnancy-induced antithrombin deficiency (PIATD) may reflect enhanced vascular permeability and may ..
  31. ncbi Comparison of intramuscular magnesium sulfate with low dose intravenous magnesium sulfate regimen for treatment of eclampsia
    Joydeb Roy Chowdhury
    Department of Gynecology and Obstetrics, NRS Medical College, Kolkata, West Bengal, India
    J Obstet Gynaecol Res 35:119-25. 2009
    Our objective was to compare intramuscular (i.m.) magnesium sulfate with a low dose intravenous (i.v.) magnesium sulfate regimen in prevention of convulsion recurrence and maternal deaths in women with eclampsia.
  32. pmc Improved quality of management of eclampsia patients through criteria based audit at Muhimbili National Hospital, Dar es Salaam, Tanzania. Bridging the quality gap
    Hussein Lesio Kidanto
    Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 12:134. 2012
    ..This study discusses the use of a CBA to improve quality of care among eclampsia patients admitted at a University teaching hospital in Dar es Salaam Tanzania.
  33. ncbi Diagnosis, prevention, and management of eclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Obstet Gynecol 105:402-10. 2005
    ..Cerebral imaging suggests that cerebral abnormalities in eclampsia (mostly vasogenic edema) are similar to those found in hypertensive encephalopathy...
  34. ncbi Fetal sex and differential survival in preeclampsia and eclampsia
    Muktar H Aliyu
    Department of Preventive Medicine and Institute for Global Health, Vanderbilt University, Nashville, TN, USA
    Arch Gynecol Obstet 285:361-5. 2012
    We investigate sex differences in the incidence of stillbirth, neonatal mortality, and perinatal mortality among singletons born to mothers with preeclampsia or eclampsia.
  35. ncbi Incidence, risk factors, and associated complications of eclampsia
    Shiliang Liu
    Health Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Obstet Gynecol 118:987-94. 2011
    To estimate trends in incidence and identify risk factors and maternal and neonatal consequences of eclampsia in Canada.
  36. ncbi Risk factors for eclampsia: a population-based study in Washington State, 1987-2007
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Obstet Gynecol 205:553.e1-7. 2011
    We sought to investigate whether previously identified risk factors are associated with eclampsia in a contemporary, heterogeneous cohort of women.
  37. ncbi Guidelines for the management of hypertensive disorders of pregnancy 2008
    Sandra A Lowe
    Royal Hospital for Women, Sydney, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 49:242-6. 2009
    ..of severe hypertension, the use of automated blood pressure monitors, the definition of non-proteinuric pre-eclampsia and measuring proteinuria...
  38. ncbi Hospital, simulation center, and teamwork training for eclampsia management: a randomized controlled trial
    Denise Ellis
    Department of Obstetrics and Gynaecology, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom
    Obstet Gynecol 111:723-31. 2008
    To compare the effectiveness of training for eclampsia in local hospitals and a regional simulation center, with and without teamwork theory.
  39. pmc Criteria-based audit on management of eclampsia patients at a tertiary hospital in Dar es Salaam, Tanzania
    Hussein Lesio Kidanto
    Department of Obstetrics and Gynaecology, Muhimbili National Hospital, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 9:13. 2009
    ..study discusses the introduction of a criteria-based audit in a tertiary hospital in an African setting, assesses the quality of care among eclampsia patients and discusses possible interventions in order to improve the quality of care.
  40. ncbi Management of eclampsia at AKTH: before and after magnesium sulphate
    J Tukur
    Department of Obstetrics and Gynaecology, Bayero University, Aminu Kano Teaching Hospital, Kano
    Niger J Med 19:104-7. 2010
    b>Eclampsia contributes significantly to maternal and perinatal morbidity and mortality in Nigeria...
  41. pmc Eclampsia: still a problem in Bangladesh
    Mosammat Rashida Begum
    OB GYN Dhaka Medical College and Hospital, Bangladesh
    MedGenMed 6:52. 2004
    ..Although magnesium sulfate controls convulsion efficiently, death from eclampsia remains high in our country...
  42. ncbi An Australian twin study of the genetic basis of preeclampsia and eclampsia
    S A Treloar
    Queensland Institute of Medical Research and the Joint Genetics Program, The University of Queensland, Brisbane, Australia
    Am J Obstet Gynecol 184:374-81. 2001
    OBJECTIVE: We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin ..
  43. ncbi Magnesium sulphate and other anticonvulsants for women with pre-eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford Institute for Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, UK, BD9 6RJ
    Cochrane Database Syst Rev 11:CD000025. 2010
    b>Eclampsia, the occurrence of a seizure (fit) in association with pre-eclampsia, is rare but potentially life-threatening. Magnesium sulphate is the drug of choice for treating eclampsia...
  44. ncbi Pre-eclampsia, birth weight, and autism spectrum disorders
    Joshua R Mann
    Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, 29203, USA
    J Autism Dev Disord 40:548-54. 2010
    ..78, p = .001 for each additional kilogram). Maternal pre-eclampsia/eclampsia was significantly associated with greater odds of ASD (OR = 1.85, p < ...
  45. ncbi A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia
    Michael A Belfort
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    N Engl J Med 348:304-11. 2003
    Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia. Nimodipine is a calcium-channel blocker with specific cerebral vasodilator activity...
  46. ncbi Strategies to prevent eclampsia in a developing country: II. Use of a maternal pictorial card
    I MacGillivray
    Institute of Child Health, University of Bristol, UK
    Int J Gynaecol Obstet 87:295-300. 2004
    To assess the efficacy and acceptability of a patient-held pictorial card aimed at raising awareness and appropriate health seeking behavior in response to prodromal symptoms of imminent eclampsia.
  47. ncbi Recent advances in pre-eclampsia and eclampsia
    Lucy Chappell
    Trop Doct 34:1. 2004
  48. ncbi [Maternal mortality due to pre-eclampsia/eclampsia in a state in southern Brazil]
    Vânia Muniz Néquer Soares
    Universidade Tuiuti do Paraná, Curitiba, PR, Brasil
    Rev Bras Ginecol Obstet 31:566-73. 2009
    to identify the profile, tendency and causes of maternal death by pre-eclampsia/eclampsia in Paraná.
  49. ncbi Magnesium sulphate as an anticonvulsant in the management of eclampsia
    Rehana Ahmed
    Department of Obstetrics and Gynaecology, Sobhraj Maternity Hospital, CDGK, Karachi
    J Coll Physicians Surg Pak 14:605-7. 2004
    ..To evaluate the use of magnesium sulphate (MgSO4) as an anticonvulsant in the management of eclamptic patients...
  50. ncbi [Fatal complications in pre-eclampsia and eclampsia]
    B Srp
    Gynekologicko porodnická klinika UK, 1 LF a VFN v Praze
    Ceska Gynekol 67:365-71. 2002
    Analysis of preeclampsia and eclampsia--one of the major contributor to life-threatening maternal morbidity frequently leading to maternal mortality in the Czech Republic till late 70's...
  51. ncbi Is serum magnesium estimate necessary in patients with eclampsia on magnesium sulphate?
    B A Ekele
    Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    Afr J Reprod Health 9:128-32. 2005
    ..Even where the laboratory facility is available, it is suggested that serum estimation be limited to cases where clinical monitors suggest toxicity...
  52. ncbi Therapeutic magnesium for eclampsia: an unusual cause for antepartum flaccid paralysis
    M Nethravathi
    J Postgrad Med 53:79-80. 2007
  53. ncbi Increased plasma hyaluronan in severe pre-eclampsia and eclampsia
    S Berg
    Department of Anaesthesiology, University Hospital Linkoping, Sweden
    Scand J Clin Lab Invest 61:131-7. 2001
    Pre-eclampsia is a serious multi-system disorder with general endothelial disease, often with a component of hepatic dysfunction...
  54. ncbi Epidural compared with general anaesthesia for caesarean delivery in conscious women with eclampsia
    J Moodley
    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Congella, South Africa
    BJOG 108:378-82. 2001
    ..caesarean section under epidural anaesthesia with that of general anaesthesia in "stable" women with eclampsia. DESIGN: Retrospective review...
  55. ncbi Risk factors for eclampsia in Japan between 2005 and 2009
    Mamoru Morikawa
    Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan
    Int J Gynaecol Obstet 117:66-8. 2012
    To determine risk factors for eclampsia among Japanese women with singleton pregnancies.
  56. ncbi Clinical and radiological differences in posterior reversible encephalopathy syndrome between patients with preeclampsia-eclampsia and other predisposing diseases
    T G Liman
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    Eur J Neurol 19:935-43. 2012
    ..In this study, we aimed to investigate the clinical and imaging characteristics of PRES in preeclampsia-eclampsia patients compared with other predisposing diseases in a large cohort.
  57. ncbi Maternal and fetal outcome in patients with eclampsia at Murtala Muhammad specialist Hospital Kano, Nigeria
    Ibrahim A Yakasai
    Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital Kano, Nigeria
    Ann Afr Med 10:305-9. 2011
    b>Eclampsia is a major contributor to maternal and perinatal mortality worldwide. It is much more common in developing countries like Nigeria where presentation is usually late and resources are scarce...
  58. ncbi Severe pre-eclampsia and hypertensive crises
    N Arulkumaran
    Renal Section, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, London, Greater London NW1 2BU, UK Electronic address
    Best Pract Res Clin Obstet Gynaecol 27:877-84. 2013
    ..in pregnancy is associated with a spectrum of severity, ranging from mild pregnancy-induced hypertension to eclampsia. Although most cases of pre-eclampsia may be managed successfully, severe pre-eclampsia is a life-threatening ..
  59. ncbi Prothrombin G20210A mutation: is it associated with pre-eclampsia?
    J R Higgins
    Department of Obstetrics and Gynaecology, University of Melbourne, Vic, Australia
    Gynecol Obstet Invest 50:254-7. 2000
    A strong independent association between the prothrombin G20210A gene mutation and pre-eclampsia has been reported in an Italian population. This result was not confirmed in a subsequent study in a Dutch population...
  60. pmc An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management
    Jeffrey Michael Smith
    JHPIEGO, 1776 Massachusetts Ave, Washington, DC 20036, USA
    BMC Pregnancy Childbirth 13:34. 2013
    Pre-eclampsia/eclampsia is one of the most common causes of maternal and perinatal morbidity and mortality in low and middle income countries...
  61. pmc Clinical morbidities, trends, and demographics of eclampsia: a population-based study
    Alex Fong
    Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, CA, USA
    Am J Obstet Gynecol 209:229.e1-7. 2013
    We sought to identify trends, demographics, and prepregnancy and peripartum morbidities of eclampsia in California.
  62. ncbi [Analysis of maternal morbidity and mortality among patients admitted to Obstetric Intensive Care with severe preeclampsia, eclampsia or HELLP syndrome]
    E Curiel-Balsera
    Unidad de Cuidados Intensivos Maternal, Hospital Regional Universitario Carlos Haya, Malaga, Espana
    Med Intensiva 35:478-83. 2011
    ..To describe the incidence and clinical and epidemiological profile of patients with severe preeclampsia admitted to Intensive Care...
  63. ncbi Effect of pre-eclampsia-eclampsia on major cardiovascular events among peripartum women in Taiwan
    Yu Sheng Lin
    Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Am J Cardiol 107:325-30. 2011
    ..population-based study to clarify the association between major adverse cardiovascular events (MACEs) and pre-eclampsia/eclampsia...
  64. ncbi Eclampsia and its association with external factors
    Surraya Halimi
    Departmenet of Obstetrics and Gynaecology, Saidu Medical College, Swat, Pakistan
    J Ayub Med Coll Abbottabad 22:110-2. 2010
    b>Eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. Primigravida are at higher risk of convulsions and antepartum convulsions are more dangerous than those beginning after delivery...
  65. ncbi Eclampsia in Sweden
    Gill Kullberg
    Department of Obstetrics and Gynaecology, Orebro Medical Center Hospital, Orebro, Sweden
    Hypertens Pregnancy 21:13-21. 2002
    Assess the actual rate of eclampsia in Sweden, describe the clinical picture of the disease and the maternal and perinatal outcomes.
  66. ncbi Hypertensive diseases and eclampsia
    Jenny E Myers
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Manchester, UK
    Curr Opin Obstet Gynecol 14:119-25. 2002
    Worldwide, pre-eclampsia and eclampsia contribute to the death of a pregnant woman every 3 min...
  67. ncbi Magnesium for preventing and treating eclampsia: time for international action
    Shirish S Sheth
    2 2 Navjivan Society, Lamington Road, Mumbai 400 008, India
    Lancet 359:1872-3. 2002
  68. ncbi Maternal and fetal outcome of anaesthesia for caesarean delivery in preeclampsia/eclampsia in Enugu, Nigeria: a retrospective observational study
    U V Okafor
    Department of Anaesthesia, University of Nigeria Teaching Hospital, Enugu, Nigeria
    Int J Obstet Anesth 14:108-13. 2005
    ..Accurate data are available for caesarean sections in the University of Nigeria Teaching Hospital, Enugu. We therefore studied the outcome of caesarean section among these high-risk patients...
  69. ncbi Late postpartum eclampsia
    S Chhabra
    Department of Obstetrics and Gynaecology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India mail com
    J Obstet Gynaecol 32:264-6. 2012
    Studies lack data regarding incidence, risk factors, optimal treatment and outcome of postpartum eclampsia (PPE), convulsions within 7 days (mostly convulsions occur within 24 - 48 h) after delivery of fetus placenta...
  70. ncbi Spontaneous bilateral perirenal hematomas in two patients with eclampsia
    Issam M Kably
    Emergency Radiology Department, CHU Ibn Rochd, 20 Lot Mimosas, Bd Ibnou Sina, Casablanca 20100, Morocco
    J Nephrol 16:267-71. 2003
    ..cases of spontaneous and bilateral perirenal hematomas that occurred during a pregnancy complicated by eclampsia. The sonographic and computed tomographic findings included bilateral perirenal hematoma with no evidence of an ..
  71. ncbi Posterior reversible leukoencephalopathy in a case of postpartum eclampsia
    Maryam Parisaei
    Department of Obstetrics and Gynaecology, Homerton University Hospital, London, United Kingdom
    Am J Obstet Gynecol 193:885-6. 2005
    This case report describes an atypical presentation of eclampsia. A 26-year-old lady presented 5 days' postpartum with a series of grand mal seizures after an uneventful pregnancy and delivery...
  72. pmc Predictors of extra care among magnesium sulphate treated eclamptic patients at Muhimbili National Hospital, Tanzania
    Projestine S Muganyizi
    Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences MUHAS, Dar es Salaam, Tanzania
    BMC Pregnancy Childbirth 11:41. 2011
    The inclusion of Magnesium Sulphate (MgSO4) as a gold standard in the treatment of eclampsia has substantially reduced incidences of repeated fits, eclamptic morbidity and deaths...
  73. ncbi Eclampsia in advanced abdominal pregnancy
    B A Ekele
    Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    Niger J Clin Pract 10:343-5. 2007
    The occurrence of eclampsia in an extra uterine pregnancy is a very rare entity. We report a case of a patient with eclampsia and advanced extra-uterine pregnancy...
  74. pmc Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control
    Steven J Wagner
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:851-6. 2011
    To assess the prevalence, clinical presentations, and neuroimaging abnormalities in a series of patients treated for eclampsia at Mayo Clinic in Rochester, MN.
  75. ncbi Maternal pre-eclampsia is associated with childhood epilepsy in South Carolina children insured by Medicaid
    Joshua R Mann
    Department of Family and Preventive Medicine, University of South Carolina School of Medicine, 3209 Colonial Drive, Columbia, SC 29210, USA
    Epilepsy Behav 20:506-11. 2011
    We examined the association between maternal pre-eclampsia/eclampsia (PE) and childhood epilepsy.
  76. ncbi Advances in the understanding of eclampsia
    S Ananth Karumanchi
    University of Chicago, 5841 South Maryland Avenue, MC 5100, Chicago, IL 60637, USA
    Curr Hypertens Rep 10:305-12. 2008
    ..b>Eclampsia-new-onset seizures in the setting of preeclampsia-usually occurs before or within 48 hours of delivery, but can ..
  77. ncbi Comparison of magnesium sulfate and mannitol in treatment of eclamptic women with posterior reversible encephalopathy syndrome
    Bilge Cetinkaya Demir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Nilufer, 16059 Bursa, Turkey
    Arch Gynecol Obstet 286:287-93. 2012
    ..To evaluate and compare the effectiveness of magnesium sulfate (MgSO(4)) and mannitol in the treatment of posterior reversible encephalopathy syndrome (PRES) in eclamptic women...
  78. ncbi Non-aneurysmal primary subarachnoid hemorrhage in pregnancy-induced hypertension and eclampsia
    A K Shah
    Wayne State University Detroit Medical Center, Detroit, MI, USA
    Neurology 61:117-20. 2003
    Clinical as well as neuroimaging studies of women with eclampsia or pregnancy-induced hypertension (PIH) have described a variety of neurologic manifestations, including intraparenchymal brain hemorrhage...
  79. ncbi Severe preeclampsia and eclampsia in Kerman, Iran: complications and outcomes
    Bibi Shahnaz Aali
    Kerman University of Medical Sciences and Health Services, Kerman, Iran
    Med Sci Monit 10:CR163-7. 2004
    Our objective was to assess the frequency, epidemiological factors, complications, and outcome of severe preeclampsia and eclampsia and compare them according to severity of the condition in Kerman, southeastern Iran.
  80. ncbi Eclampsia complicated by abdominal compartment syndrome
    Christine E Richter
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Perinatol 26:751-3. 2009
    A primigravida with eclampsia and hemolytic anemia, elevated liver enzymes, and low platelet count (HELLP syndrome) developed intra-abdominal compartment syndrome requiring a decompressive laparotomy, underlining the importance of ..
  81. ncbi The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia
    Jamilu Tukur
    Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital Bayero University, Kano, Nigeria
    Ann Afr Med 8:76-80. 2009
    Pre-eclampsia and eclampsia are important causes of maternal and perinatal morbidity and mortality in the developing countries. There is need to provide the most effective management to pre-eclamptic and eclamptic patients...
  82. ncbi Characteristics of preeclampsia- and eclampsia-related maternal death in rural Haiti
    Maria J Small
    Yale University School of Medicine, Yale University School of Public Health, Division of Maternal Fetal Medicine, New Haven, CT 06520 8063, USA
    J Matern Fetal Neonatal Med 18:343-8. 2005
    ..Preeclampsia- and eclampsia-related complications are one of the leading causes of maternal death...
  83. ncbi Evolutionary adaptations to pre-eclampsia/eclampsia in humans: low fecundability rate, loss of oestrus, prohibitions of incest and systematic polyandry
    Pierre Yves Robillard
    Neonatology, Centre Hospitalier Sud Reunion, Saint Pierre Cedex, Reunion, France
    Am J Reprod Immunol 47:104-11. 2002
    Gestational-hypertension/pre-eclampsia occurs in approximately 10% of human pregnancies...
  84. ncbi Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia
    A H Shaamash
    Department of Obstetrics and Gynecology, Assiut University, Assiut, Egypt
    Int J Gynaecol Obstet 68:207-14. 2000
    To measure the maternal and fetal serum concentrations of total nitrites and nitrates (as an index of nitric oxide production) in normal pregnancy, pre-eclampsia and eclampsia.
  85. ncbi Brain lesions several years after eclampsia
    Annet M Aukes
    School for Behavioral and Cognitive Neurosciences, University Medical Center Groningen, Groningen, The Netherlands
    Am J Obstet Gynecol 200:504.e1-5. 2009
    b>Eclampsia is thought to have no long-term neurological consequences...
  86. ncbi Eclampsia: morbidity, mortality, and management
    Kjersti M Aagaard-Tillery
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Clin Obstet Gynecol 48:12-23. 2005
  87. ncbi Preeclampsia: increasing incidence but improved outcome?
    Marian Knight
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
    Am J Hypertens 21:491. 2008
  88. ncbi Maternal and perinatal outcome of eclampsia in tertiary health institution in Southeast Nigeria
    Echendu Dolly Adinma
    Department of Community Medicine, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
    J Matern Fetal Neonatal Med 26:211-4. 2013
    To evaluate the maternal and perinatal outcome in patients with eclampsia at Nnamdi-Azikiwe-University-Teaching-Hospital (NAUTH), Nnewi, Nigeria.
  89. ncbi Eclampsia, hippocampal sclerosis, and temporal lobe epilepsy: accident or association?
    N Lawn
    UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, USA
    Neurology 62:1352-6. 2004
    ..Up to 30% of patients with temporal lobe epilepsy (TLE) have no identifiable risk factors...
  90. ncbi Eclampsia and abnormal QTc
    S A Isezuo
    Departments of Medicine, Usman Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    West Afr J Med 23:123-7. 2004
    Abnormalities of calcium and magnesium metabolism are known risk factors for QT interval prolongation and have been reported in eclampsia.
  91. ncbi Late postpartum eclampsia: report of two cases managed by uterine curettage and review of the literature
    Koji Matsuo
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Perinatol 24:257-66. 2007
    The purpose of this study was describe two patients with rapid recovery of refractory late postpartum eclampsia (LPPE) following uterine curettage, and to evaluate the literature about supportive evidence for such a management in LPPE...
  92. ncbi The 'Severe Hypertensive Illness in Pregnancy' (SHIP) audit: promoting quality care using a high risk monitoring chart and eclampsia treatment pack
    K Joanne Baldwin
    North Staffordshire Hospital and Keele University, UK
    J Obstet Gynaecol 22:346-52. 2002
    ..Intervention comprised feedback of baseline results to each hospital, a monitoring chart and eclampsia treatment pack...
  93. ncbi Acute renal failure during eclampsia: incidence risks factors and outcome in intensive care unit
    Khalid Mjahed
    Service d Anesthésie réanimation Centrale, CHU Ibn Rochd, Casablanca, Morocco
    Ren Fail 26:215-21. 2004
    To assess the incidence, risk factors and the outcome of acute renal failure (ARF) associated with eclampsia in intensive care unit (ICU).
  94. ncbi Delayed postpartum preeclampsia and eclampsia: demographics, clinical course, and complications
    Zain Al-Safi
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine Detroit Medical Center, Detroit, Michigan 48201, USA
    Obstet Gynecol 118:1102-7. 2011
    To estimate and evaluate the demographics, clinical course, and complications of delayed postpartum preeclampsia in patients with and without eclampsia.
  95. ncbi Polymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia
    Ayfer Pazarbasi
    Department of Medical Biology and Genetics, University of Cukurova, Faculty of Medicine, Balcali, Adana 01330, Turkey
    Acta Med Okayama 61:153-60. 2007
    The genetic background predisposing pregnant women to pre-eclampsia/eclampsia (PE/E) is still unknown...
  96. ncbi Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit
    Aliye Esmaoglu
    Department of Anesthesiology and Intensive Care, University of Erciyes, Kayseri, Turkey 38039
    J Crit Care 24:551-5. 2009
    This study compares the effectiveness of midazolam and dexmedetomidine for the sedation of eclampsia patients admitted to our intensive care unit (ICU).
  97. ncbi Maternal cigarette smoking and the risk of pregnancy-induced hypertension and eclampsia
    Qiuying Yang
    OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ontario, Canada
    Int J Epidemiol 35:288-93. 2006
    ..No previous study has specifically examined the relationship between maternal smoking and eclampsia.
  98. ncbi Bilateral total loss of vision following eclampsia--a case report
    M J Waziri-Erameh
    Department of Ophthalmology, College of Medical Sciences, University of Benin, Benin City, Nigeria
    Afr J Reprod Health 7:106-8. 2003
    Visual loss following eclampsia is usually reported to be a result of retinopathy, exudative retinal detachment or cortical blindness...
  99. ncbi Eclampsia: a neurological perspective
    A K Shah
    Department of Neurology, Wayne State University Detroit Medical Center, Detroit, MI 48201, United States
    J Neurol Sci 271:158-67. 2008
    b>Eclampsia is a poorly understood disorder characterized by seizures or unexplained coma in setting of gestational hypertension...
  100. ncbi No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population
    Meral Cetin
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey
    J Obstet Gynaecol Res 31:236-41. 2005
    There is substantial evidence that genetic factors play a role in pre-eclampsia. The aim of this study was to determine whether genetic variability in the encoding of genes for glutathione S-transferase M1 (GSTM1) and glutathione S-..
  101. ncbi Strategies to prevent eclampsia in a developing country: I. Reorganization of maternity services
    A M McCaw-Binns
    Department of Community Health and Psychiatry, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies, Jamaica
    Int J Gynaecol Obstet 87:286-94. 2004
    To determine whether changes in primary and secondary care service delivery could prevent antenatal eclampsia.

Research Grants62

  1. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..Hypertension may lead to pre-eclampsia, which can restrict fetal growth or trigger premature birth...
  2. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..feature of a healthy pregnancy, shallow invasion is associated with placental pathologies, among them pre-eclampsia (PE) and intra-uterine growth retardation (IUGR)...
  3. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..is rapidly becoming a major obstetric complication since it increases the risk of gestational diabetes and pre-eclampsia, and predisposes the mother for later metabolic and cardiovascular disease...
  4. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia. PCOS results in a significant health care burden to our economy with an estimated $500 million spent annually ..
  5. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..the mother's kidneys, liver and other vital organs and, if undetected or untreated, can lead to seizures (eclampsia), cerebral hemorrhage, failure in vital organs (i.e., kidney and heart) and death...
  6. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..pregnancy complications like recurrent miscarriage (fetal loss), intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
  7. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes, pre-eclampsia, or cesarean delivery, the best strategy during their pregnancy may be to maintain a steady weight rather than ..
  8. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    A current hypothesis for the etiology of pre-eclampsia is that endothelial dysfunction is secondary to oxidative stress and some clinical studies have indicated that prophylactic administration of anti-oxidants may be useful in its ..
  9. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ..the opportunity to investigate the pathogenesis and develop preventive and therapeutic interventions for pre-eclampsia, polycystic ovary syndrome, perinatal depression, preterm birth, low birth weight, vaginal bacteriosis, breast ..
  10. Novel ex-vivo Immunoadsorption Therapy to Treat Preeclampsia
    Woo Joo; Fiscal Year: 2013
    ..by the onset of hypertension and proteinuria and can lead to more serious complications, such as seizure (eclampsia) and HELLP syndrome associated with systemic organ failure and death...
  11. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..covered by training mentors, including polycystic ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea vaccine development, steroidogenesis, and promotion of ..
  12. Pregnancy complications, future cardiovascular disease risk factors and cardiovas
    NISHA INDRAVADAN PARIKH; Fiscal Year: 2013
    ..that have been demonstrated to predict CVD risk factors and CVD include pregnancy- induced hypertension or pre-eclampsia, gestational diabetes, having a small for gestational age infant, a low or very high number of pregnancies, pre-..
  13. Development of a Yoga Intervention for Antenatal Depression
    Cynthia L Battle; Fiscal Year: 2012
    ..Antenatal depression is linked to many adverse outcomes, including higher rates of spontaneous abortion, pre-eclampsia, operative delivery, postpartum depression, neonatal growth retardation, pre-term delivery, low birth weight, ..
  14. 2010 Gordon Research Conference on Endothelial Cell Phenotypes in Health and Dise
    Edward Conway; Fiscal Year: 2010
    ..the role of the endothelial cell in the placenta, pregnancy and eclampsia, 3. the eye and the vascular endothelium, 4. understanding the endothelium in tissue engineering, 5...
  15. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2012
    ..of placental HCMV infection, including first trimester pregnancy loss, intrauterine growth restriction, pre-eclampsia and preterm labor, are believed to be mediated by the inability of extravillous cytotrophoblasts (EVT) to ..
  16. Use of PAP in women with pre-eclampsia
    LOUISE M O'BRIEN; Fiscal Year: 2013
    Pre-eclampsia is a pregnancy-specific disorder characterized by hypertension and proteinuria observed after the 20th week of gestation. It affects 5-8% of U.S...
  17. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2013
    b>Eclampsia is a serious complication of pregnancy that occurs when hypertension during pregnancy develops with neurologic complications, including headache, vomiting, blindness and convulsions...
  18. Prenatal Conditions and the Pathway to Obesity and Diabetes in Children
    Steven D Chernausek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pre-eclampsia (PE) is associated with an increased risk for diabetes mellitus (DM) for both mother and child...
  19. Glycated CD59 as a novel biomarker of gestational diabetes mellitus
    Jose A Halperin; Fiscal Year: 2013
    ..H 25 million Americans, 2) and GDM is a major source of adverse pregnancy outcomes including macrosomia and pre-eclampsia. The proposed work opens the possibility of using glyCD59 as a biomarker for GDM, an innovative departure from ..
  20. ANIMAL MODELS FOR STUDYING THE GENETICS OF HYPERTENSION
    Oliver Smithies; Fiscal Year: 2013
    ..Pre-eclampsia (PE) is a common form of pregnancy-associated hypertension and proteinuria...
  21. HIF-1 Alpha Regulation of Trophoblast Differentiation in Vivo
    Thomas L Brown; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many pregnancy-associated disorders, including IUGR and pre-eclampsia, stem from abnormal placental development...
  22. Perinatal depression, proinflammatory cytokines and adverse obstetric outcomes
    Emma K Robertson Blackmore; Fiscal Year: 2010
    ..women, and has been linked with adverse outcomes for the mother and baby, including low birth weight, pre-eclampsia, premature labor and delivery and fetal growth restriction...
  23. Long-Term Burden of Maternal Cardiovascular Risk Factors and Birth Outcomes
    EMILY WHEELER HARVILLE; Fiscal Year: 2013
    ..risk factors are associated with pregnancy complications (gestational hypertension, gestational diabetes and pre-eclampsia), and whether this explains the relationship between pre-pregnancy cardiovascular risk and PTB/IUGR;4) To ..
  24. Early Warning system for detecting pre-eclampsia
    Tammy Y Euliano; Fiscal Year: 2013
    ..The cost of the device allows for a per use cost of as little as five cents. It will support better decision making regarding patient management including level of monitoring, delivery planning and therapeutic interventions. ..
  25. High Performance Computing System for Human Genomics
    John Blangero; Fiscal Year: 2010
    ..involved in human common complex diseases, including cardiovascular disease, diabetes, obesity, aging, pre-eclampsia, psychiatric disorders and infectious diseases...
  26. Elucidating Key Mechanisms Regulating Cell Invasion In Vivo
    David R Sherwood; Fiscal Year: 2013
    ..is also co-opted or misregulate during many diseases, including asthma, arthritis, the pregnancy disorder pre-eclampsia, and cancer...
  27. Identification of Pre-eclampsia Susceptibility Genes
    Eric Moses; Fiscal Year: 2010
    Pre-eclampsia/eclampsia (PE/E) is the most common and serious disorder of human pregnancy and is associated with substantial maternal and perinatal morbidity and mortality...
  28. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..and fetal mortality and morbidity are threatened by the hypertension, proteinuria and pathological edema of pre-eclampsia. Studies are proposed that will further define mechanisms responsible for the control of atrial natriuretic ..
  29. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..resistance or how NO may buffer vasoconstriction and that a defect in NO production may be involved in pre-eclampsia. Despite increasing evidence that NO also modulates mitochondrial metabolism and substrate uptake by the heart, ..
  30. Acquisition of a Nano Computed Tomography Instrument for shared Cornell Imaging f
    CHRISTOPHER JOHN HERNANDEZ; Fiscal Year: 2013
    ..and other defects in bone;b) treatment of osteoarthritis;c) the development of lung cancer;e) uterine pre- eclampsia;d) congenital defects in the heart and will be used in future investigations on these health topics and others.
  31. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    ..The relation of maternal vitamin D status to important complications of pregnancy (gestational diabetes and pre-eclampsia). 3...
  32. FETAL ERYTHROID CELLS IN MATERNAL CIRCULATION
    STEPHEN GRANT; Fiscal Year: 1999
    ..will then be applied to incident maternal/fetal pairs with a variety of adverse outcomes, including pre- eclampsia. This study will also provide samples for the development and application of techniques for fetal cell ..
  33. North Dakota INBRE: Health and the Environment
    Donald A Sens; Fiscal Year: 2013
    ..community with the successful establishment of a genetics-based, undergraduate-driven research program on pre-eclampsia at Turtle Mountain Community College...
  34. The Role of Leptin in Placental Development
    Laura Schulz; Fiscal Year: 2009
    ..First, insufficient trophoblast invasion is associated with pre-eclampsia, the most common complication of pregnancy, and one which can be fatal...
  35. PERINATAL FACTORS AND BREAST CANCER
    Dimitrios Trichopoulos; Fiscal Year: 2000
    ..of fetal size; to confirm the negative association between breast cancer risk and maternal eclampsial pre-eclampsia; to examine the observed positive association between breast cancer risk and prematurity and neonatal jaundice; ..
  36. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2004
    ..in the first trimester, is associated with significant complications of pregnancy, including miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR)...
  37. Target regulation of neuronal plasticity
    David Pettigrew; Fiscal Year: 2009
    ..Failure of this "natural" plasticity occurs in pathological situations such as pre-eclampsia, which can be fatal to both mother and fetus...
  38. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2003
    ..macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia. To accomplish this, the investigators propose to conduct five nested case-control studies, one for each of the ..
  39. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    ..neonate, but also on pregnancy outcome, including spontaneous abortion, intrauterine growth restriction and pre-eclampsia. Despite the significant morbidity and mortality associated with congenital CMV infection, little is known about ..
  40. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..intervention or prevention of abnormalities in trophoblast invasion, including infertility, ectopic pregnancy, and pre-eclampsia. The investigators work with the human model because of the uniqueness of implantation in humans.
  41. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    DARCY BARRY CARR; Fiscal Year: 2004
    PROPOSAL (Adapted from the applicant's abstract): Pre-eclampsia, a hypertensive disorder unique to pregnancy, is a leading cause of maternal and neonatal morbidity and mortality...
  42. ANGIOTENSIN PROSTANOIDS & HEMODYNAMICS DURING PREGNANCY
    Gail Brown; Fiscal Year: 1991
    ..A deterioration in renal and systemic hemodynamics often heralds the onset of pre-eclampsia with attendant risks of fetal and maternal morbidity...
  43. THE PHYSIOLOGY OF PLACENTAL LACTOGEN
    Stuart Handwerger; Fiscal Year: 2006
    ..action or syncytin expression may lead to placental disorders such as choriocarcinoma, hydatidiform mole and pre-eclampsia. The specific aims are to test the hypotheses that 1) the syncytin and AP-2cz genes are coordinately regulated ..
  44. DEVELOPMENTAL BIOLOGY OF THE IMPLANTING MAMMALIAN EMBRYO
    Roger Pedersen; Fiscal Year: 2000
    ..assisted conception, and diseases of the trophoblast such as choriocarcinoma, hydatidiform mole and pre-eclampsia. These problems can ultimately be resolved only through mammalian studies, as undertaken in the Program, which ..
  45. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2006
    ..Twenty-four of these deaths were directly attributable to complications of eclampsia and preeclampsia. An additional four deaths were related to chronic hypertension...
  46. Antepartum Interpersonal Psychotherapy at 3 NYC Sites
    Margaret Spinelli; Fiscal Year: 2009
    ..APD causes low birth weight, prematurity and eclampsia. APD is one of the best predictors of postpartum depression (PPD), which in turn causes impaired infant and ..
  47. IMPROVING PDC/MWRI INSTITUTIONAL ANIMAL RESOURCES
    Gerald Schatten; Fiscal Year: 2003
    ..On-going projects include studies in amenorrhea, pre-eclampsia, pregnancy loss, and sexually transmitted diseases...
  48. PEPTIDE PROCESSING ENZYMES IN THE PLACENTA
    Sandra Reznik; Fiscal Year: 2002
    ..which alterations in the enzymes that process and metabolize Endothelin-1 are related to the pathogenesis of pre-eclampsia and pre-term labor and by which alterations in the carboxypeptidases that process a variety of peptide hormones ..
  49. Angiogenic & Premeability Growth Factors in Preeclampsia
    Donna Johnson; Fiscal Year: 2002
    Pre-eclampsia is a multisystem disorder that complicates 10 percent of pregnancies. This disease leads to increased morbidity and mortality for both the mother and baby...
  50. THE GENETICS OF PREGNANCY-INDUCED SEIZURES IN MICE
    Andrew Smolen; Fiscal Year: 1992
    ..One serious complication of pregnancy in human is preeclampsia/eclampsia, which is characterized by edema, proteinuria, hypertension, and spontaneous, life threatening seizures...
  51. Interaction between Oxidative Stress-Related Genes and Nutrients in Pre-eclampsia
    Mai T Nguyen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pre-eclampsia is defined as an increase in blood pressure and the presence of proteinuria after 20 weeks of gestation...
  52. PERINATAL AND ADOLESCENT FACTORS IN BREAST CANCER
    Sherri Stuver; Fiscal Year: 2002
    ..and adolescent somatic growth; to examine the association between perinatal complications, such as pregnancy pre-eclampsia/eclampsia, jaundice, and prematurity, and indicators of sexual maturity and somatic growth during adolescence...
  53. Social Networks and Skilled Birth Attendance to Prevent Maternal Mortality
    JOYCE EDMONDS; Fiscal Year: 2010
    ..Preventable and treatable conditions such as post-partum hemorrhage, sepsis, eclampsia and obstructed labor are the leading causes of maternal deaths worldwide...
  54. MATERNO-FETAL RESPONSE TO REDUCED UTERINE BLOOD FLOW
    Kenneth Clark; Fiscal Year: 1980
    ..alteration, there is an increased incidence of premature labor, intra-uterine growth retardation and pre-eclampsia. These complications of pregnancy are also directly associated with an increased incidence of brain damaged and ..
  55. Pre-eclampsia and risk for CVD in SLE patients
    Pin Lin; Fiscal Year: 2005
    ..disease (CVD) is increased in both systemic lupus erythematosus (SLE) patients and non-lupus women who had pre-eclampsia during pregnancy...
  56. PROSTAGLANDIN E., RENIN AND UTEROPLACENTAL BLOOD FLOW
    Rocco Venuto; Fiscal Year: 1980
    ..Pharmacologic and surgical methods will be employed to devise an animal model of human pre-eclampsia. Circulating levels of prostaglandin E as well as renin will be measured in pregnant patients in an attempt to ..
  57. HSF 1 Requirements in Extraembryonic Development
    Ivor Benjamin; Fiscal Year: 2005
    ..propose such information can constitute a rational basis to interventions involving HSF1 in the diagnosis, prognosis, and therapy for conditions such as pre-eclampsia and intrauterine growth retardation in humans.
  58. SIGNALING PATHWAYS MEDIATING TROPHOBLAST PROLIFERATION
    Daniel Rappolee; Fiscal Year: 2005
    ..Therefore, the proposed studies should lead to improvement in methods to facilitate placentation and improve IVF and produce protocols for remediation of common defects in pregnancy such as pre-eclampsia and IUGR.
  59. UTERINE VASCULAR RESPONSE TO STEROID SIGNALING
    Ira Bernstein; Fiscal Year: 2002
    ..is associated with specific reproductive inadequacy, including infertility, fetal growth restriction and pre-eclampsia. While estrogen and progesterone have been clearly implicated as signals mediating the adaptive hemodynamic ..
  60. MIDCAREER AWARD IN PATIENT ORIENTED OBSTETRIC RESEARCH
    Dwight Rouse; Fiscal Year: 2004
    ..Second, the incidence of some severe but preventable obstetric outcomes (e.g., eclampsia) is quite low, but even for such low incidence conditions, it is often desirable to evaluate interventions which ..
  61. CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTH
    LORNA MOORE; Fiscal Year: 2003
    ..uterine artery vasoregulation and growth, and thus contribute to fetal growth restriction and possibly pre-eclampsia. The central working hypothesis is that chronic hypoxia impairs vasoregulatory and growth related responses of ..
  62. Effect of Leptin on Trophoblast Invasiveness
    Laura Schulz; Fiscal Year: 2006
    ..by which nutrition affects placental development, and increase our understanding of the role of leptin in pre-eclampsia, a common complication of pregnancy characterized by insufficient trophoblast invasion...