vulvar neoplasms

Summary

Summary: Tumors or cancer of the VULVA.

Top Publications

  1. ncbi Vulvar cancer
    Timothy P Canavan
    Department of Family and Community Medicine, Lancaster General Hospital, Pennsylvania, USA
    Am Fam Physician 66:1269-74. 2002
  2. ncbi Trends in the incidence of invasive and in situ vulvar carcinoma
    Patricia L Judson
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Obstet Gynecol 107:1018-22. 2006
  3. ncbi Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors
    Jennifer S Smith
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Obstet Gynecol 113:917-24. 2009
  4. ncbi Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis
    Hugo De Vuyst
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 124:1626-36. 2009
  5. ncbi Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women
    E A Joura
    Department of Gynecology and Obstetrics, University of Vienna, Austria
    J Reprod Med 45:613-5. 2000
  6. ncbi Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age
    Hedwig P van de Nieuwenhof
    Department of Obstetrics and Gynaecology 791, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Cancer 45:851-6. 2009
  7. ncbi Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer
    Monika Hampl
    Department of Gynecology and Obstetrics, Institute of Pathology, University Hospital, Heinrich Heine University, Duesseldorf, Germany
    Obstet Gynecol 108:1361-8. 2006
  8. ncbi Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients
    Manon van Seters
    Department of Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gynecol Oncol 97:645-51. 2005
  9. ncbi Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination
    Petr Skapa
    Department of Pathology and Molecular Medicine, Charles University, 2nd Medical School, Faculty Hospital Motol, Prague, Czech Republic
    Am J Surg Pathol 31:1834-43. 2007
  10. ncbi Gynaecologic cancer complicating pregnancy: an overview
    Frederic Amant
    Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 24:61-79. 2010

Research Grants

  1. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
  2. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2007
  3. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2007
  4. A Molecular Signature of Early Cervical Carcinoma
    Concepcion Diaz Arrastia; Fiscal Year: 2007
  5. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2007
  6. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
  7. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2007
  8. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
  9. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
  10. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010

Detail Information

Publications179 found, 100 shown here

  1. ncbi Vulvar cancer
    Timothy P Canavan
    Department of Family and Community Medicine, Lancaster General Hospital, Pennsylvania, USA
    Am Fam Physician 66:1269-74. 2002
    ..Treatment is surgical resection, with the goal being complete removal of the tumor. There has been a recent trend toward more conservative surgery to decrease psychosexual complications...
  2. ncbi Trends in the incidence of invasive and in situ vulvar carcinoma
    Patricia L Judson
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Obstet Gynecol 107:1018-22. 2006
    ..To characterize the incidence of vulvar carcinoma in situ and vulvar cancer over time...
  3. ncbi Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors
    Jennifer S Smith
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Obstet Gynecol 113:917-24. 2009
    ..Our aim was to conduct a systematic review of HPV type distribution in vulvar and vaginal invasive carcinomas, vulvar intraepithelial neoplasia (VIN), and vaginal intraepithelial neoplasia...
  4. ncbi Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis
    Hugo De Vuyst
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 124:1626-36. 2009
    ..This proportion would be similar for the corresponding high-grade lesions of the vagina and anus, but higher for VIN2/3 (75%) than for vulvar carcinoma...
  5. ncbi Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women
    E A Joura
    Department of Gynecology and Obstetrics, University of Vienna, Austria
    J Reprod Med 45:613-5. 2000
    ..To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade...
  6. ncbi Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age
    Hedwig P van de Nieuwenhof
    Department of Obstetrics and Gynaecology 791, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Cancer 45:851-6. 2009
    ....
  7. ncbi Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer
    Monika Hampl
    Department of Gynecology and Obstetrics, Institute of Pathology, University Hospital, Heinrich Heine University, Duesseldorf, Germany
    Obstet Gynecol 108:1361-8. 2006
    ..We assessed the prevalence of HPV (and the types) to estimate the possible effect of a HPV vaccine on lower genital tract disease prevention...
  8. ncbi Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients
    Manon van Seters
    Department of Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gynecol Oncol 97:645-51. 2005
    ..To establish the true natural history of VIN III from literature data...
  9. ncbi Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination
    Petr Skapa
    Department of Pathology and Molecular Medicine, Charles University, 2nd Medical School, Faculty Hospital Motol, Prague, Czech Republic
    Am J Surg Pathol 31:1834-43. 2007
    ....
  10. ncbi Gynaecologic cancer complicating pregnancy: an overview
    Frederic Amant
    Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 24:61-79. 2010
    ..Firstly, we describe general diagnostic and cancer-treatment-related problems. In the second part, organ pathology including breast, cervical, ovarian, endometrial and vulvar cancer is discussed...
  11. ncbi Carcinoma of the vulva
    Frederick B Stehman
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Obstet Gynecol 107:719-33. 2006
    ..Adequately powered trials aimed at further reducing morbidity without compromising survival are underway...
  12. ncbi Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Gynecol Oncol 100:271-5. 2006
    ..To evaluate various treatment modalities for vulvar intraepithelial neoplasia (VIN) in relation to possible risk factors for recurrence...
  13. ncbi Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways
    I A M van der Avoort
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Gynecol Pathol 25:22-9. 2006
    ..First, an HPV-dependent pathway with a remarkable resemblance to CIN lesions and cervical carcinoma and second, an HPV-independent pathway in which differentiated VIN III lesions that are hr-HPV-negative may be precursors...
  14. ncbi Human papillomavirus infections and vulvar disease development
    Suzanne M Garland
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical University of Vienna, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
    Cancer Epidemiol Biomarkers Prev 18:1777-84. 2009
    ....
  15. ncbi Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee
    Mario Sideri
    European Institute of Oncology, Milan, Italy
    J Reprod Med 50:807-10. 2005
    ..The term VIN 1 will no longer be used. Two categories should describe squamous VIN: VIN, usual type (encompassing former VIN 2 and 3 of warty, basaloid and mixed types) and VIN, differentiated type (VIN 3, differentiated type)...
  16. ncbi Prognostic significance of lymph node variables and human papillomavirus DNA in invasive vulvar carcinoma
    Alvaro P Pinto
    Department of Pathology, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
    Gynecol Oncol 92:856-65. 2004
    ..The present study investigates the influence of lymph node pathological features and HPV DNA status on the prognosis of vulvar invasive tumors...
  17. ncbi Failure in the detection of the sentinel lymph node with a combined technique of radioactive tracer and blue dye in a patient with cancer of the vulva and a single positive lymph node
    G Fons
    Department of Gynaecology and Obstetrics, Academic Medical Centre, Amsterdam, The Netherlands
    Gynecol Oncol 92:981-4. 2004
    ..No detection failures have been published so far in vulvar cancer. We recently experienced failure in the detection of the sentinel lymph node in a patient with a positive lymph node...
  18. ncbi Vulvar intraepithelial neoplasia in adolescents with abnormal Pap smear results: a series report
    Eduardo Lara-Torre
    Kaza Medical Group, 113 Neurology Way, Milford, DE 19963, USA
    J Pediatr Adolesc Gynecol 17:45-8. 2004
    ..The objective of this study was to determine the prevalence of vulvar intraepithelial neoplasia (VIN) in adolescents presenting for cervical colposcopy in an adolescent gynecology office...
  19. ncbi New and surprising insights into pathogenesis of multicentric squamous cancers in the female lower genital tract
    Qinghua Feng
    J Natl Cancer Inst 97:1798-9. 2005
  20. ncbi [Coexistence of VIN and vulvar invasive cancer with intraepithelial neoplasia and invasive carcinoma of the cervix and/or vagina, and HPV infection of the low female genital tract]
    Katarzyna Adamek
    ,
    Ginekol Pol 74:657-61. 2003
    ..These data suggest an important role of HPV infection in low female genital tract carcinogenesis and obliges to a precise examination of the entire low female genital tract, especially in young women...
  21. ncbi Pathologic evaluation of inguinal sentinel lymph nodes in vulvar cancer patients: a comparison of immunohistochemical staining versus ultrastaging with hematoxylin and eosin staining
    Richard G Moore
    Program in Women s Oncology, Department of Obstetrics and Gynecology, 101 Dudley Street, Women and Infants Hospital, Brown University, Providence, RI 02905, USA
    Gynecol Oncol 91:378-82. 2003
    ..To evaluate the value of immunohistochemical (IHC) staining of inguinal sentinel lymph nodes (SLN) found to be negative for metastatic disease by ultrastaging with hematoxylin and eosin (H&E) staining...
  22. ncbi Vulvar squamous cell carcinoma: guidelines for early diagnosis and treatment
    Stephen K Tyring
    UTMB Center for Clinical Studies, University of Texas Medical Branch, 301 University Boulevard, Route 1070, Galveston, TX 77555, USA
    Am J Obstet Gynecol 189:S17-23. 2003
    ..This review discusses the etiology, clinical characteristics, and diagnostic staging of vulvar SCC. Treatment options are reviewed, including novel topical immunotherapies such as imiquimod...
  23. ncbi Prediction of lymph node metastases in vulvar cancer: a review
    M H M Oonk
    Department of Gynaecologic Oncology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Int J Gynecol Cancer 16:963-71. 2006
    ..The minimally invasive sentinel node procedure is a promising technique for selecting patients for complete lymphadenectomy, but its safety has not been proven yet...
  24. ncbi Small vulvar squamous cell carcinomas and adjacent tissues. A morphologic study
    Hemming Poulsen
    Department of Pathology, Hvidovre University Hospital, Institute of Pathology, Herlev University Hospital, Denmark
    APMIS 111:835-42. 2003
    ..Five of these cases were incompletely surrounded by varying degrees of dysplasia, mainly VIN2 and VIN3. Two different pathogenetic pathways for the development of vulvar squamous cell carcinoma are likely...
  25. ncbi p14ARF, a prognostic predictor in HPV-negative vulvar carcinoma
    Synne Knopp
    Department of Pathology, and the University of Oslo, Faculty Division, the Norwegian Radium, Hospital, Oslo, Norway
    Am J Clin Pathol 126:266-76. 2006
    ..In patients with HPV- tumors expressing high levels of p53, low p14 indicated the poorest 5-year disease-specific survival...
  26. ncbi EGFR expression is associated with groin node metastases in vulvar cancer, but does not improve their prediction
    M H M Oonk
    Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700RB Groningen, The Netherlands
    Gynecol Oncol 104:109-13. 2007
    ..Aim of the study was to evaluate whether in addition to 'classic' clinicopathological factors determination of EGFR expression in vulvar cancer can be helpful in defining such a 'low-risk' group...
  27. ncbi The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN)
    Monica Srodon
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1513-8. 2006
    ..Finally, comparison of the distribution of HPV in the vagina and vulva suggests that VaIN is more closely related to cervical intraepithelial neoplasia than to VIN...
  28. ncbi Squamous cell carcinoma antigen serum levels as prognostic parameter in patients with early stage vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 97:904-7. 2005
    ..To determine whether SCC-Ag serum levels can be used as a prognostic parameter in surgically treated early stage vulvar cancer...
  29. ncbi Vulval lipoma: a rare occurrence
    Umber Agarwal
    Department of Obstetrics and Gynaecology, Pt. B.D. Sharma, PGIMS, 124001 Rohtak, Haryana, India
    Arch Gynecol Obstet 270:59-60. 2004
  30. ncbi Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women
    Ronald W Jones
    Vulvar Clinic, Department of Gynecologic Oncology, National Women s Hospital, Auckland, New Zealand
    Obstet Gynecol 106:1319-26. 2005
    ..To determine the clinical characteristics, outcome following surgical treatment, and natural history of cases of untreated vulvar intraepithelial neoplasia (VIN)...
  31. ncbi Cyclins D1, D3, E, and A in vulvar carcinoma patients
    Synne Knopp
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Gynecol Oncol 97:733-9. 2005
    ..The aim of this study was to characterize the expression of cyclins D1, D3, E, and A in a comparatively large series of patients with vulvar squamous cell carcinoma and look for prognostic impact...
  32. ncbi Lymphatic mapping of sentinel nodes in early vulvar cancer
    G Sliutz
    Department of Gynecology, University of Vienna, Vienna, A 1090, Austria
    Gynecol Oncol 84:449-52. 2002
    ..The aim of the study was to determine the diagnostic accuracy and feasibility of sentinel lymph node (SLN) detection using a gamma probe in patients suffering from vulvar cancer...
  33. ncbi Intratumoral oxygenation of invasive squamous cell carcimoma of the vulva is not correlated with regional lymph node metastasis
    J E Stone
    Department of Gynecology, Department of Gynecologic Oncology, University of British Columbia, Vancouver
    Eur J Gynaecol Oncol 26:31-5. 2005
    ..Only preoperative anaemia is correlated with nodal metastasis in early ISCC of the vulva...
  34. ncbi Outcomes for patients with T1 squamous cell cancer of the vulva undergoing sentinel node biopsy
    Keith Y Terada
    Department of Obstetrics and Gynecology, University of Hawaii School of Medicine, Honolulu, HI 96822, USA
    Gynecol Oncol 102:200-3. 2006
    ..This retrospective review was undertaken to evaluate survival in patients with T1 squamous cell carcinoma of the vulva treated with radical local excision and sentinel node dissection...
  35. ncbi p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias
    Sabine Riethdorf
    , , Hamburg, Germany
    Hum Pathol 35:1477-83. 2004
    ..These disparate patterns of p16 expression underscore 2 different mechanisms for p16 expression in HPV-related and HPV-unrelated vulvar carcinomas...
  36. ncbi Patterns of recurrence and disease-free survival in advanced squamous cell carcinoma of the vulva
    Isam Lataifeh
    Queensland Centre for Gynaecological Cancer, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD 4029, Australia
    Gynecol Oncol 95:701-5. 2004
    ..The current FIGO staging system inaccurately reflects prognosis for patients with advanced vulval cancer. Clinical trials are warranted to investigate the benefit of systemic treatment...
  37. ncbi Sentinel node dissection in vulvar cancer
    Amy A Hakim
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, Suite 420, 333 East Superior Street, Chicago, IL 60611, USA
    Curr Treat Options Oncol 7:85-91. 2006
    ..Patients with positive sentinel nodes may then undergo additional therapy. Patients with negative sentinel nodes are theoretically at very low risk for metastases and should not require any additional treatment...
  38. ncbi High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia
    Frederic Goffin
    , Pathologie et Microbiologie-Infectiologie, , CHUM, , , Canada
    J Med Virol 78:814-9. 2006
    ..2). Multifocal vulvar HPV infection was detected in women with previous or active VIN-3. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN-3...
  39. ncbi Occult lymph node metastases in early stage vulvar carcinoma patients
    Synne Knopp
    Department of Pathology, University of Oslo, Faculty Division, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Gynecol Oncol 99:383-7. 2005
    ....
  40. ncbi Pitfalls in the sentinel lymph node procedure in vulvar cancer
    J A de Hullu
    Department of Gynecologic Oncology, University Medical Centre Nijmegen, The Netherlands
    Gynecol Oncol 94:10-5. 2004
    ..CONCLUSION: Gynecological oncologists who perform the sentinel lymph node procedure in vulvar cancer patients should perform this technique by following a strict protocol and within the protection of a clinical trial...
  41. ncbi Clinical and pathological prognostic factors in squamous cell carcinoma of the vulva
    Francesco Raspagliesi
    Department of Gynecologic Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Gynecol Oncol 102:333-7. 2006
    ..The objective of this study was the prognostic analysis of clinicopathologic variables related to primary tumor and to lymph node metastases...
  42. ncbi The frequency of human papillomavirus infection in polish patients with vulvar squamous cell carcinoma
    Magdalena Kowalewska
    Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology, 5 W K Roentgena, 02 781 Warsaw, Poland
    Int J Gynecol Cancer 20:434-7. 2010
    ..In contrast to the established relationship of virtually all cervical cancer cases with the human papillomavirus (HPV) infection, the reported HPV positivity in vulvar carcinoma ranges widely...
  43. ncbi Serum levels of squamous cell carcinoma antigen as a predictor of inguinofemoral lymph node metastasis in patients with vulvar cancer
    Andreas Nather
    Department of Gynecology and Obstetrics, University of Vienna General Hospital, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Reprod Med 47:718-20. 2002
    ..To evaluate the predictive value of preoperatively determined squamous cell carcinoma antigen (SCC-Ag) serum levels for the risk of inguinofemoral lymph node metastasis...
  44. ncbi Recurrent squamous cell carcinoma of the vulva: clinicopathologic determinants identifying low risk patients
    M Preti
    Department of Gynecology and Obstetrics, University of Turin, Turin, Italy
    Cancer 88:1869-76. 2000
    ..The identification of prognostic factors in the recurrence of vulvar squamous cell carcinoma is crucial for less invasive treatments...
  45. ncbi Detection of sentinel nodes by lymphoscintigraphy and gamma probe guided surgery in vulvar neoplasia
    M Sideri
    Division of Gynecology, European Institute of Oncology, Milan, Italy
    Tumori 86:359-63. 2000
    ..The present study evaluates the feasibility of the surgical identification of inguinal sentinel nodes using lymphoscintigraphy and a gamma detecting probe in patients with early vulvar cancer...
  46. ncbi Vulvar intraepithelial neoplasia: historical aspects and current status
    W R Hart
    Division of Pathology and Laboratory Medicine (L21, The Cleveland Clinic Foundation, 9500 Euclid Avenue Cleveland, Ohio 44195, USA
    Int J Gynecol Pathol 20:16-30. 2001
    ..This manuscript summarizes the historical development and current status of our knowledge about VIN. Information on the clinical and pathologic aspects are detailed and illustrated, as are considerations of differential diagnosis...
  47. ncbi The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva
    G V Narayansingh
    Gynaecology Oncology Unit, Ward 43, Aberdeen Royal Infirmary, AB25 2ZN, UK
    Br J Cancer 92:222-4. 2005
    ..In total, 13 women (42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20-fold higher in those with micrometastases compared to those without (hazard ratio=19.6 (95% CI 2.3-171)...
  48. ncbi Sentinel node dissection is safe in the treatment of early-stage vulvar cancer
    Ate G J van der Zee
    Department of Obstetrics and Gynecology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 26:884-9. 2008
    ..To investigate the safety and clinical utility of the sentinel node procedure in early-stage vulvar cancer patients...
  49. ncbi Decreased survival in EGFR gene amplified vulvar carcinoma
    Whitfield B Growdon
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, THR 901A, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Gynecol Oncol 111:289-97. 2008
    ....
  50. ncbi Prognostic significance of epithelial disorders adjacent to invasive vulvar carcinomas
    R Rouzier
    Department of Gynecologic Surgery, Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif Cedex, 94805, France
    Gynecol Oncol 81:414-9. 2001
    ..CONCLUSION: The results of this study support the view that histological evidence of epithelial alterations adjacent to invasive carcinoma can serve to separate patients that differ in terms of prognosis...
  51. ncbi Sentinel lymph node detection and microstaging in vulvar carcinoma
    K L Molpus
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198 3255, USA
    J Reprod Med 46:863-9. 2001
    ..To determine the efficacy of using complementary techniques for detecting sentinel lymph nodes (SLNs) in vulvar carcinoma and to evaluate the utility of microstaging techniques...
  52. ncbi The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
    Zhihui Wang
    Division of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    BMC Cancer 8:308. 2008
    ..However, the exact role of 14-3-3sigma in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3sigma protein expression is still unknown...
  53. ncbi A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma
    Brigiet M Hoevenaars
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 123:2767-73. 2008
    ..In conclusion, both pathways leading to vulvar SCC have their own immunohistochemical profile, which can be used to distinguish the 2 types of VIN, but cannot explain differences in malignant potential...
  54. ncbi Increased angiogenesis is associated with poor prognosis of squamous cell carcinoma of the vulva
    Veera V Näyhä
    Department of Pathology, University of Oulu, Oulu, Finland
    Acta Obstet Gynecol Scand 86:1392-7. 2007
    ..Increased angiogenesis is associated with an increased risk of malignant transformation in many organs. The occurrence, characteristics and significance of angiogenesis in vulvar squamous cell carcinoma are less well known...
  55. ncbi Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review
    Liana Abramova
    Department of Surgery, University of Virginia Health Science Center, Charlottesville, Virginia 22906, USA
    Ann Surg Oncol 9:840-6. 2002
    ..CONCLUSIONS: This experience, plus reports of a small number of patients from three similar studies, supports the impression that sentinel lymph node biopsy is feasible for vulvar and vaginal melanoma...
  56. ncbi Clinicopathologic comparison of vulvar and extragenital lichen sclerosus: histologic variants, evolving lesions, and etiology of 141 cases
    J A Carlson
    Division of Dermatopathology and Dermatology, Albany Medical College, New York 12208, USA
    Mod Pathol 11:844-54. 1998
    ....
  57. ncbi Serum concentrations of squamous-cell carcinoma antigen and tissue polypeptide antigen in the follow-up of patients with vulvar cancer
    L Hefler
    Department of Gynaecology and Obstetrics, University of Vienna Medical School, Vienna, Austria
    Int J Cancer 83:167-70. 1999
    ..Furthermore, our data indicate that combining SCC-Ag with TPA is not a successful strategy to improve the sensitivity or the duration of lead-time effects in the follow-up of patients with vulvar cancer...
  58. ncbi Sentinel lymph node in vulvar cancer
    Jan Hauspy
    Division of Gynecologic Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Cancer 110:1015-23. 2007
    ..The aim of the study was to assess the feasibility, efficacy, and accuracy of the sentinel lymph node (SLN) procedure in vulvar cancer...
  59. ncbi Invasive mucinous (colloid) adenocarcinoma of ectopic breast tissue in the vulva: a case report
    C Yin
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    Breast J 9:113-5. 2003
    ..The tumor cells were positive for estrogen receptors (ERs), progesterone receptors (PRs), and BRST-1 markers. The clinical and pathologic features, differential diagnosis, and treatment are discussed...
  60. ncbi Further data on the usefulness of sentinel lymph node identification and ultrastaging in vulvar squamous cell carcinoma
    Luis M Puig-Tintore
    Section of Gynecologic Oncology, Institut Clinic de Ginecologia, Obstetricia i Neonatologia ICGON, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Gynecol Oncol 88:29-34. 2003
    ....
  61. ncbi Sentinel node biopsy in early vulvar cancer
    C De Cicco
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Br J Cancer 82:295-9. 2000
    ..This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer...
  62. ncbi A review of molecular pathological markers in vulvar carcinoma: lack of application in clinical practice
    S Knopp
    Division of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    J Clin Pathol 62:212-8. 2009
    ..Therefore, the investigated markers have not yet earned a place in standard clinical diagnostics or treatment, and further studies are needed to clarify the clinical value of these markers...
  63. ncbi Fibroadenoma of the mammary-like glands of the vulva
    J D Sington
    Histopathology 41:563-5. 2002
  64. ncbi Complete remission after neoadjuvant chemoradiation in a stage IV vulvar cancer patient
    Annett Bischoff
    Department of Radiooncology, Charite University Hospital, Berlin, Germany
    Strahlenther Onkol 184:421-5. 2008
    ..The authors report on a modified neoadjuvant radiochemotherapy schedule which is isoeffective to the GOG (Gynecologic Oncology Group) protocol, but associated with less therapy-related toxicity...
  65. ncbi Surgery for vulvar cancer
    R Rouzier
    Centre Hospitalier Intercommunal de Creteil, Creteil, France
    Clin Obstet Gynecol 48:869-78. 2005
  66. ncbi Rapid groin recurrence of a vulvar carcinoma with invasion of the femoral vessels and the importance of the initial groin dissection in the staging surgery
    E Buxant
    Department of Gynaecology, Erasme Hospital, Free University of Brussels, ULB, Brussels, Belgium
    Acta Chir Belg 105:418-9. 2005
    ..The disease spreads from the vulva through embolization to the locoregional lymphatic station, the inguinofemoral nodes. The single most important prognostic factor is the presence or absence of nodal disease...
  67. ncbi Galectin-3 and CD1a-positive dendritic cells are involved in the development of an invasive phenotype in vulvar squamous lesions
    Hermann Brustmann
    Department of Pathology, Thermenklinikum, Moedling Vienna, Austria
    Int J Gynecol Pathol 25:30-7. 2006
    ....
  68. ncbi How safe is sentinel lymph node biopsy in patients with vulvar cancer?
    Charles F Levenback
    J Clin Oncol 26:828-9. 2008
  69. ncbi Patterns of inguinal groin metastases in squamous cell carcinoma of the vulva
    Jesus Gonzalez Bosquet
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Gynecologic Surgery, Mayo Clinic Rochester, SW Rochester, MN 55905, USA
    Gynecol Oncol 105:742-6. 2007
    ..Assess whether the identified pattern of lymphatic spread supports the current surgical practice of assessing contralateral nodes for lateral lesions with ipsilateral nodal involvement...
  70. ncbi [Diagnosis and management of vulvar intraepithelial neoplasias and invasive vulvar cancers]
    Philippe Sauthier
    Service de gynécologie oncologique, Département d Obstétrique et Gynécologie, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Gynakol Geburtshilfliche Rundsch 47:88-93. 2007
    ..Update on the diagnosis and management of vulvar intraepithelial neoplasia (VIN) and vulvar carcinoma...
  71. ncbi Expression of ZNF652, a novel zinc finger protein, in vulvar carcinomas and its relation to prognosis
    R Holm
    Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Clin Pathol 61:59-63. 2008
    ..To determine the levels of expression of ZNF652 and its relevance to prognosis in vulvar squamous cell carcinomas...
  72. ncbi Gynecologic Oncology Group risk groups for vulvar carcinoma: improvement in survival in the modern era
    Lisa M Landrum
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Oklahoma University Health Sciences Center, PO Box 26901, WP2410, Oklahoma City, OK 73190, USA
    Gynecol Oncol 106:521-5. 2007
    ..The purpose of this study is to reassess these risk groups in patients treated in an era of contemporary management...
  73. ncbi In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology
    M van Seters
    Department of Gynaecology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Clin Pathol 60:504-9. 2007
    ..It is commonly assumed that differentiated VIN is related to lichen sclerosus (LS). However, evidence for this is limited to a small number of studies describing epithelial alterations adjacent to vulvar SCC...
  74. ncbi the management of vulval intraepithelial neoplasia in Northern Ireland
    A A Zawislak
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland
    Int J Gynecol Cancer 16:780-5. 2006
    ..VIN should be managed by clinicians with expertise in this field and who are treating significant numbers of patients according to evidence-based protocols...
  75. ncbi Computerized nuclear morphometry for the prediction of inguinal lymph nodes metastases in squamous cell carcinoma of the vulva
    O Lavie
    Gynecologic Oncology Unit, Carmel Medical Center, Haifa, Israel
    Int J Gynecol Cancer 16:556-61. 2006
    ..The results of our study justify the need for a prospective study of a larger number of patients to evaluate the reproducibility and the clinical use of the data...
  76. ncbi Patterns and frequency of recurrences of squamous cell carcinoma of the vulva
    Jorien M Woolderink
    Department of Gynaecological Oncology CMC V, University Medical Center Groningen, University of Groningen, 4th Floor, PO Box 30.001, 9700 RB Groningen, The Netherlands
    Gynecol Oncol 103:293-9. 2006
    ..After a local recurrence, 72% of the patients developed a second local recurrence. These patients are at high risk and need a close follow-up...
  77. ncbi Pagetoid squamous cell carcinoma in situ of the vulva: comparison with extramammary paget disease and nonpagetoid squamous cell neoplasia
    Jane E Armes
    Department of Anatomical Pathology, Mater Health Services, South Brisbane, Queensland, Australia
    Int J Gynecol Pathol 27:118-24. 2008
    ..Additionally, as with nonpagetoid squamous cell neoplasias of the vulvar, integration of high-risk HPV may occur in some, but not all, cases of PSSCIS...
  78. ncbi Isolated sentinel lymph node dissection with conservative management in patients with squamous cell carcinoma of the vulva: a prospective trial
    Richard G Moore
    Program in Women s Oncology, Women and Infants Hospital, Brown University, Providence, RI 02905, USA
    Gynecol Oncol 109:65-70. 2008
    ..The objective of this study was to examine the inguinal recurrence rate along with complication rates for patients undergoing inguinal SLN dissection alone for vulvar carcinoma...
  79. ncbi Comparison of outcome and recurrence-free survival after sentinel lymph node biopsy and lymphadenectomy in vulvar cancer
    Silke Johann
    Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital and University of Bern, Switzerland
    Gynecol Oncol 110:324-8. 2008
    ..Sentinel lymph node biopsy (SLNB) was established for less invasive lymph node (LN) staging. The aim of this study was to evaluate safety of SLNB in terms of accuracy and outcome in a clinical routine setting...
  80. ncbi p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN)
    B Liegl
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    Histopathology 48:268-74. 2006
    ..CONCLUSION: d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS...
  81. ncbi Further data on sentinel lymph node mapping in vulvar cancer by blue dye and radiocolloid Tc99
    Lukas Rob
    Department of Obstetrics and Gynecology, Motol University Hospital, 2nd Medical Faculty, Charles University, V Uvalu 84, 06 Prague 5, Czech Republic
    Int J Gynecol Cancer 17:147-53. 2007
    ..The combined use of (99m)Tc radiocolloid and blue dye was significantly superior at SLN detection than blue dye alone. (99m)Tc SLN detection using the intraoperative handheld probes was not enhanced by preoperative scintigraphy scans...
  82. ncbi Squamous cell carcinoma of the vulva and adjacent lesions treated at Nagoya University Hospital from 1965 to 1997
    K Akashi
    Department of Laboratory Medicine, and Obstetrics and Gynecology of Nagoya University School of Medicine, Japan
    Nagoya J Med Sci 64:109-21. 2001
    ..One reason for the low incidence of VSCC is largely due to race; the homogeneous, monoethnic Japanese population, as well as the few cases of HPV-related VSCC...
  83. ncbi Impact of inguinal dissection on prognosis of early-stage squamous cell carcinoma of the vulva--a retrospective analysis
    J R Kouvaris
    Department of Radiology Radiotherapy, Aretaeion Hospital, University of Athens, Greece
    Onkologie 26:564-7. 2003
    ..Inclusion of inguinal lymphadenectomy in the surgical procedure is a potential prognostic factor for squamous cell vulvar carcinoma...
  84. ncbi Successful treatment of a high-grade intraepithelial neoplasia with imiquimod, with vulvar pemphigus as a side effect
    G Campagne
    Department of Obstetrics and Gynecology, Clinica Bella Medica, Partida Cap Negret 17, 03590 Altea, Spain
    Eur J Obstet Gynecol Reprod Biol 109:224-7. 2003
    ..The posterior biopsies confirm the absence of lesions but show drug-induced pemphigus as a side effect...
  85. ncbi Bowenoid papulosis of the vulva-immunotherapeutical approach with topical imiquimod
    O N Richter
    Department of Obstetrics and Gynecology, University of Bonn School of Medicine, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gynecol Obstet 268:333-6. 2003
    ..Imiquimod cream is a topical immune response modifier with indirect antiviral and antitumor effects through the stimulation of local cytokine production and cell-mediated immune response...
  86. ncbi Groin recurrence in patients with vulvar cancer with negative nodes on superficial inguinal lymphadenectomy
    Mary E Gordinier
    Program in Women's Oncology, Brown University/Women and Infants' Hospital, Providence, RI, USA
    Gynecol Oncol 90:625-8. 2003
    ..SIL as performed on the patients in this study did not eliminate all sites of nodal metastasis...
  87. ncbi Risk of occult inguinofemoral lymph node metastasis from squamous carcinoma of the vulva
    Jesus Gonzalez Bosquet
    Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 57:419-24. 2003
    ..This study may help to assess the effectiveness of current therapies...
  88. ncbi The role of radiation therapy in preventing regional recurrences of invasive squamous cell carcinoma of the vulva
    Angela Katz
    Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Int J Radiat Oncol Biol Phys 57:409-18. 2003
    ..CONCLUSION: RT alone or in combination with LND is highly effective in preventing INR in patients with squamous cell carcinoma of the vulva and is associated with a low risk of major late complications...
  89. ncbi Human papillomavirus infection and p53 protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma
    D E S Engelman
    Departamento de Patologia Anatômica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Braz J Med Biol Res 36:1159-65. 2003
    ..Our findings are similar to others and support the hypothesis that there are two separate entities of the disease, one associated with HPV and the other unrelated, with p53 inactivation possibly being implicated in some of the cases...
  90. ncbi [Pregnancy and delivery after conservative surgical treatment and radiotherapy of vulvar carcinoma]
    Hanna Makarewicz
    ,
    Ginekol Pol 74:61-5. 2003
    ..Such therapy allowed to preserve fertility and the patient conceived and delivered. Partial post-irradiation damage of the uterus might have caused immature labor...
  91. ncbi Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
    A N Rosenthal
    Department of Obstetrics and Gynaecology, The Gynecological Oncology Unit, Bart s and The London, Queen Mary School of Medicine and Dentistry, London University, UK
    Br J Cancer 88:251-6. 2003
    ....
  92. ncbi Advanced primary carcinoma of the Bartholin gland: report of 18 patients
    O Balat
    Department of Obstetrics and Gynecology, University of Gaziantep, Sahinbey Medial Center, Turkey
    Eur J Gynaecol Oncol 22:46-9. 2001
    ..1300). The present study demonstrated WLE followed by RT is the best treatment for advanced primary carcinoma of the Bartholin gland. Less radical surgery plus RT produces good long-term survival and has fewer complications...
  93. ncbi An update on vulvar cancer
    G B Ghurani
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL 33136, USA
    Am J Obstet Gynecol 185:294-9. 2001
    ..New approaches using lymphatic mapping with sentinel node dissection appear promising for the future treatment of early vulvar cancers...
  94. ncbi Groin recurrence after micrometastasis in a sentinel lymph node in a patient with vulvar cancer
    Karl F Tamussino
    Department of Obstetrics and Gynecology, University of Graz, Austria
    Gynecol Oncol 86:99-101. 2002
    ..The sentinel lymph node concept is attractive in vulvar cancer because of the potential to avoid the morbidity associated with formal groin dissection...
  95. ncbi Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions
    K J Rolfe
    Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    Int J Gynecol Cancer 11:381-6. 2001
    ..Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease...
  96. ncbi High-grade vulval intraepithelial neoplasia (VIN 3): a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989-1999
    Peter Sykes
    Department of Obstetrics and Gynaecology, Christchurch School of Medicine, New Zealand
    Aust N Z J Obstet Gynaecol 42:69-74. 2002
    ..The true rate of malignant progression in untreated patients remains unclear and radical surgery is rarely indicated. All patients require long-term follow up...
  97. ncbi Expression of epithelial growth factor receptor and its two ligands, transforming growth factor-alpha and epithelial growth factor, in normal and neoplastic squamous cells in the vulva: an immunohistochemical study
    X Wu
    Department of Gynecology, The First Clinical College, China Medical University, Shenyang, China
    Med Electron Microsc 34:179-84. 2001
    ..EGFR expression appeared to contribute to essential neoplastic abnormalities in 64% of the VSCC...
  98. ncbi [Detecting HPV DNA in tissues of external genital squamous cell carcinoma in situ by PCR-RFLP technique]
    Jia Bi Wang
    Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:667-70. 2003
    ..To study the relationship between the infection of human papillomavirus (HPV) and external genital squamous cell carcinoma in situ...
  99. ncbi Contralateral groin recurrence in patients with stage I Bartholin's gland squamous cell carcinoma and negative ipsilateral nodes: report on two cases and implications for lymphadenectomy
    Chafika Mazouni
    Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France
    Gynecol Oncol 94:843-5. 2004
    ..CONCLUSIONS: These 2 cases suggest that << cross >> groin nodal involvement can occur, even in patients with early stage BGC. Bilateral groin dissection should be performed in patients with BGC...
  100. ncbi Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma
    Irina Rufforny
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida Shands Hospital, Gainesville, Florida, USA
    J Low Genit Tract Dis 9:108-13. 2005
    ....
  101. ncbi Radioguided sentinel lymph node detection in vulvar cancer
    C Merisio
    Maternal and Infant Care Department, University of Parma, Parma, Italy
    Int J Gynecol Cancer 15:493-7. 2005
    ..Based on literature evidence, the sentinel node procedure is feasible and reliable in vulvar cancer; however, the value of sentinel node dissection in the treatment of early-stage vulvar cancer still needs to be confirmed...

Research Grants46

  1. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
    ....
  2. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2007
    ....
  3. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2007
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  4. A Molecular Signature of Early Cervical Carcinoma
    Concepcion Diaz Arrastia; Fiscal Year: 2007
    ..I propose to identify a genomic and proteomic signature of cervical cancer that will predict the aggressive behavior of the tumor and function clinically to develop molecular-based treatment plans. ..
  5. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2007
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  6. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..We have a demonstrated record in clinical trial design and execution in this patient population, which is disproportionately comprised of minority women who do not access the medical care system effectively. ..
  7. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2007
    ..This application is written to request financial support for the clinical trial, including research nurse support, data management support, clinical trails compliance and auditing services, and clinical specimen processing and storage. ..
  8. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  9. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  10. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  11. Mechanisms of mucosal immune evasion in high grade cervical dysplasia
    Cornelia L Trimble; Fiscal Year: 2010
    ....
  12. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2009
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  13. Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Alexander Burnett; Fiscal Year: 2007
    ..The pill would have minimal or no side effects and could be available to be taken immediately at the first warning or after announcement of a nuclear explosion. ..
  14. Effect of Male Circumcision on Penile HPV Infection
    JENNIFER SUSAN SMITH; Fiscal Year: 2010
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  15. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  16. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  17. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  18. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2006
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..