vulvar neoplasms

Summary

Summary: Tumors or cancer of the VULVA.

Top Publications

  1. ncbi Vulvar cancer
    Timothy P Canavan
    Department of Family and Community Medicine, Lancaster General Hospital, Pennsylvania, USA
    Am Fam Physician 66:1269-74. 2002
  2. ncbi Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis
    Hugo De Vuyst
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 124:1626-36. 2009
  3. ncbi HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
    Lindy A M Santegoets
    Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 121:759-66. 2007
  4. ncbi Intraoperative lymphatic mapping and sentinel node identification with blue dye in patients with vulvar cancer
    C Levenback
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gynecol Oncol 83:276-81. 2001
  5. pmc The economic burden of noncervical human papillomavirus disease in the United States
    Delphine Hu
    Program in Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Obstet Gynecol 198:500.e1-7. 2008
  6. ncbi Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Cancer Res 63:6032-41. 2003
  7. doi Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors
    Jennifer S Smith
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Obstet Gynecol 113:917-24. 2009
  8. ncbi Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    J Gen Virol 84:2089-97. 2003
  9. doi Prognostic factors for recurrence and survival in primary vulvar squamous cell cancer
    Ali Ayhan
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baskent University Faculty of Medicine, Ankara, Sihhiye, Turkey
    Acta Obstet Gynecol Scand 87:1143-9. 2008
  10. ncbi Role of TP53 mutations in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, Department of Gynaecology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Int J Gynecol Pathol 30:497-504. 2011

Research Grants

  1. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2003
  2. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
  3. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2004
  4. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2005
  5. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2002
  6. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2007
  7. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2008
  8. New Strategies for Photoimmunodetection/therapy
    Mark Savellano; Fiscal Year: 2008
  9. New Strategies for Photoimmunodetection/therapy
    Mark Savellano; Fiscal Year: 2007
  10. Therapeutic HPV vaccination for stage IB1 cervical cancer
    Cornelia Trimble; Fiscal Year: 2008

Detail Information

Publications219 found, 100 shown here

  1. ncbi Vulvar cancer
    Timothy P Canavan
    Department of Family and Community Medicine, Lancaster General Hospital, Pennsylvania, USA
    Am Fam Physician 66:1269-74. 2002
    ..Treatment is surgical resection, with the goal being complete removal of the tumor. There has been a recent trend toward more conservative surgery to decrease psychosexual complications...
  2. ncbi Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis
    Hugo De Vuyst
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 124:1626-36. 2009
    ..This proportion would be similar for the corresponding high-grade lesions of the vagina and anus, but higher for VIN2/3 (75%) than for vulvar carcinoma...
  3. ncbi HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
    Lindy A M Santegoets
    Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 121:759-66. 2007
    ..Upon reviewing apoptosis and angiogenesis, it was observed that these processes have not become significantly disregulated in VIN...
  4. ncbi Intraoperative lymphatic mapping and sentinel node identification with blue dye in patients with vulvar cancer
    C Levenback
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gynecol Oncol 83:276-81. 2001
    ..To determine the effectiveness of intraoperative lymphatic with blue dye alone as a means of localizing sentinel nodes in patients with vulvar cancer...
  5. pmc The economic burden of noncervical human papillomavirus disease in the United States
    Delphine Hu
    Program in Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Obstet Gynecol 198:500.e1-7. 2008
    ....
  6. ncbi Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Cancer Res 63:6032-41. 2003
    ..Local immune infiltration may be a critical factor in potential responsiveness to vaccine therapy in HPV-associated neoplasia and should be carefully monitored in future placebo-controlled trials of immunotherapy for VIN...
  7. doi Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors
    Jennifer S Smith
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Obstet Gynecol 113:917-24. 2009
    ..Our aim was to conduct a systematic review of HPV type distribution in vulvar and vaginal invasive carcinomas, vulvar intraepithelial neoplasia (VIN), and vaginal intraepithelial neoplasia...
  8. ncbi Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    J Gen Virol 84:2089-97. 2003
    ..In spite of previous studies showing the immunogenicity of E2 in eliciting primary T-cell responses in vitro, there was a low prevalence of E2 responses in the VIN patients and controls (2/18 vs 0/17)...
  9. doi Prognostic factors for recurrence and survival in primary vulvar squamous cell cancer
    Ali Ayhan
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baskent University Faculty of Medicine, Ankara, Sihhiye, Turkey
    Acta Obstet Gynecol Scand 87:1143-9. 2008
    ..To evaluate survival estimates and clinico-pathological variables in women with primary vulvar squamous cancer...
  10. ncbi Role of TP53 mutations in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, Department of Gynaecology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Int J Gynecol Pathol 30:497-504. 2011
    ..These data support the potential utility of restoring TP53 function as a therapeutic alternative in vulvar cancer. Further studies are necessary to clarify the prognostic implications of TP53 mutations in vulvar carcinomas...
  11. doi HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women
    Maura L Gillison
    Division of Viral Oncology, Johns Hopkins, Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Cancer 113:3036-46. 2008
    ....
  12. ncbi Spontaneous regression of grade 3 vulvar intraepithelial neoplasia associated with human papillomavirus-16-specific CD4(+) and CD8(+) T-cell responses
    Isabelle Bourgault Villada
    Service de Dermatologie and Service d Anatomie pathologique, Université Versailles Saint Quentin en Yvelines, Hopital Ambroise Pare, Boulogne Billancourt, France
    Cancer Res 64:8761-6. 2004
    ..Hence, an increase of HPV-specific effector T lymphocyte responses by vaccine-based therapeutic strategies might be useful to clear the lesions in bowenoid papulosis disease...
  13. doi Sentinel node dissection is safe in the treatment of early-stage vulvar cancer
    Ate G J van der Zee
    Department of Obstetrics and Gynecology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 26:884-9. 2008
    ..To investigate the safety and clinical utility of the sentinel node procedure in early-stage vulvar cancer patients...
  14. doi Lesions of anogenital mammary-like glands: an update
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Alej Svobody 80, Pilsen, Czech Republic
    Adv Anat Pathol 18:1-28. 2011
    ..This will enable their recognition, precise classification and should introduce greater uniformity in how they are reported in the literature so that more meaningful clinicopathological comparisons and correlations may be made...
  15. ncbi Review of squamous premalignant vulvar lesions
    H P van de Nieuwenhof
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Rev Oncol Hematol 68:131-56. 2008
    ..In this review we will discuss the history, epidemiology, aetiology, histology, clinical characteristics, treatment options, malignant potential and prevention strategies of the three squamous premalignant vulvar lesions...
  16. ncbi Trends in the incidence of invasive and in situ vulvar carcinoma
    Patricia L Judson
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Obstet Gynecol 107:1018-22. 2006
    ..To characterize the incidence of vulvar carcinoma in situ and vulvar cancer over time...
  17. ncbi Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients
    Manon van Seters
    Department of Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gynecol Oncol 97:645-51. 2005
    ..To establish the true natural history of VIN III from literature data...
  18. ncbi The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN)
    Monica Srodon
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1513-8. 2006
    ..Finally, comparison of the distribution of HPV in the vagina and vulva suggests that VaIN is more closely related to cervical intraepithelial neoplasia than to VIN...
  19. pmc Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States
    A M Stroup
    University of Utah, Utah Cancer Registry, 650 Komas Drive, Suite 106B, Salt Lake City, Utah 84108, USA
    Gynecol Oncol 108:577-83. 2008
    ..Describe the treatment and survival patterns among a population-based sample of vulvar cancer patients diagnosed in the United States in 1999...
  20. pmc Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes
    Zhihui Wang
    Department of Pathology, Oslo University Hospital and University of Oslo, Norway
    BMC Cancer 10:233. 2010
    ..To shed light on their roles in the pathogenesis and to clarify their prognostic values, expression of CDC25A, CDC25B and CDC25C in a large series of vulvar squamous cell carcinomas were examined...
  21. ncbi Clinical and pathological prognostic factors in squamous cell carcinoma of the vulva
    Francesco Raspagliesi
    Department of Gynecologic Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Gynecol Oncol 102:333-7. 2006
    ..The objective of this study was the prognostic analysis of clinicopathologic variables related to primary tumor and to lymph node metastases...
  22. doi Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?
    David H Moore
    Gynecologic Oncology of Indiana, Indianapolis, IN 46237, USA
    Gynecol Oncol 113:379-83. 2009
    ..Nonetheless, patients with locally advanced vulva cancer have derived considerable benefit from chemoradiation studies in other related tumor sites, and will continue to do so in the future...
  23. doi Incidence of in situ and invasive vulvar cancer in the US, 1998-2003
    Mona Saraiya
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer 113:2865-72. 2008
    ..To provide a baseline picture before HPV vaccine implementation, the authors described vulvar cancer epidemiology by age, race, ethnicity, and histology in the US...
  24. ncbi The role of radiation therapy in preventing regional recurrences of invasive squamous cell carcinoma of the vulva
    Angela Katz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Int J Radiat Oncol Biol Phys 57:409-18. 2003
    ..To evaluate treatment of the inguinal nodes for patients with squamous cell carcinoma of the vulva...
  25. ncbi Detection of carbonic anhydrase 9-expressing tumor cells in the lymph nodes of vulvar carcinoma patients by RT-PCR
    Magdalena Kowalewska
    Department of Molecular Biology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Int J Cancer 116:957-62. 2005
    ..Our findings clearly indicate potential value of CA9 as a molecular marker for the assessment of regional lymph node status in vulvar cancer patients and support a possible utility of our RT-PCR assay in the detection of micrometastases...
  26. ncbi Carcinoma of the vulva
    Frederick B Stehman
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Obstet Gynecol 107:719-33. 2006
    ..Adequately powered trials aimed at further reducing morbidity without compromising survival are underway...
  27. ncbi Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer
    Monika Hampl
    Department of Gynecology and Obstetrics, Institute of Pathology, University Hospital, Heinrich Heine University, Duesseldorf, Germany
    Obstet Gynecol 108:1361-8. 2006
    ..We assessed the prevalence of HPV (and the types) to estimate the possible effect of a HPV vaccine on lower genital tract disease prevention...
  28. ncbi Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age
    Hedwig P van de Nieuwenhof
    Department of Obstetrics and Gynaecology 791, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Cancer 45:851-6. 2009
    ....
  29. doi Histopathological work-up and interpretation of sentinel lymph nodes removed for vulvar squamous cell carcinoma
    Sigrid Regauer
    Institute of Pathology, Working groups of Dermatopathology and Gynaecopathology, Medical University Graz, Auenbruggerplatz 25, Graz A 8036, Austria
    Histopathology 55:174-81. 2009
    ..Patients with missed inguinal disease, however, have a risk of dying from systemic disease. SLN dissections reduce morbidity, but work-up should reliably identify metastatic disease...
  30. doi Vulvar cancer in young women: demographic features and outcome evaluation
    Grainger S Lanneau
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Am J Obstet Gynecol 200:645.e1-5. 2009
    ..The objective of the study was to identify prognostic and environmental factors associated with vulvar carcinoma in young women...
  31. ncbi Cytological evaluation correlates poorly with histological diagnosis of vulvar neoplasias
    Victoria L Bae-Jump
    Division of Gynecologic Oncology, Department of Ob Gyn, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7570, USA
    J Low Genit Tract Dis 11:8-11. 2007
    ..To determine whether cytological smears of the vulva correlate with vulvar biopsies of vulvar intraepithelial neoplasias (VINs)...
  32. ncbi Terminology for vulvar cytology based on the Bethesda System
    Matías Jiménez-Ayala
    Department of Pathology, Hospital Universitario Gregorio Maranon, Hospital Universitario de Getafe, Madrid, Spain
    Acta Cytol 46:645-50. 2002
    ..To present a new terminology for vulvar cytology based on the Bethesda System...
  33. ncbi The impact of improving outcomes guidance on surgical management of vulval squamous cell cancer in southwest England (1997-2002)
    A D Falconer
    Department of Gynaecology, Derriford Hospital, Plymouth, UK
    BJOG 114:391-7. 2007
    ....
  34. ncbi The frequency of human papillomavirus infection in polish patients with vulvar squamous cell carcinoma
    Magdalena Kowalewska
    Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology, 5 W K Roentgena, 02 781 Warsaw, Poland
    Int J Gynecol Cancer 20:434-7. 2010
    ..In contrast to the established relationship of virtually all cervical cancer cases with the human papillomavirus (HPV) infection, the reported HPV positivity in vulvar carcinoma ranges widely...
  35. ncbi Have patients with early squamous carcinoma of the vulva been overtreated in the past? The Norwegian experience 1977-1991
    M Scheistrøen
    Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo
    Eur J Gynaecol Oncol 23:93-103. 2002
    ..To evaluate different surgical approaches in early squamous vulvar cancer...
  36. ncbi Local relapse in patients treated for squamous cell vulvar carcinoma: incidence and prognostic value
    Roman Rouzier
    Department of Obstetrics and Gynecology, Centre Hospitalier Intercommunal de Creteil, France
    Obstet Gynecol 100:1159-67. 2002
    ..4% (+/- 18.3%) at 1 year and 70.9% (+/- 17.6%) at 3 years.Local relapses at the site of the primary tumor or skin bridge recurrences are strong predictors for cancer-related death, but not local relapse at a distant site...
  37. ncbi Risk of occult inguinofemoral lymph node metastasis from squamous carcinoma of the vulva
    Jesus Gonzalez Bosquet
    Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 57:419-24. 2003
    ....
  38. ncbi Radical versus conservative surgery for vulvar carcinoma
    M Arvas
    Istanbul University, Cerrahpasa School of Medicine, Gynecologic Oncology Division, Istanbul, Turkey
    Int J Gynaecol Obstet 88:127-33. 2005
    ..The comparison of the radical and conservative surgical approaches for vulvar carcinoma in relation to the rate of recurrence and complications...
  39. doi A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian indigenous women
    John R Condon
    Services, Systems and Society Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT, 0811, Australia
    Cancer Causes Control 20:67-74. 2009
    ..To describe the epidemiological features of a possible disease cluster of vulvar cancer and pre-cancers in Australian Indigenous women living in the Northern Territory (NT) of Australia...
  40. ncbi Impact of inguinal dissection on prognosis of early-stage squamous cell carcinoma of the vulva--a retrospective analysis
    J R Kouvaris
    Department of Radiology Radiotherapy, Aretaeion Hospital, University of Athens, Greece
    Onkologie 26:564-7. 2003
    ..Inclusion of inguinal lymphadenectomy in the surgical procedure is a potential prognostic factor for squamous cell vulvar carcinoma...
  41. ncbi Rapid groin recurrence of a vulvar carcinoma with invasion of the femoral vessels and the importance of the initial groin dissection in the staging surgery
    E Buxant
    Department of Gynaecology, Erasme Hospital, Free University of Brussels, ULB, Brussels, Belgium
    Acta Chir Belg 105:418-9. 2005
    ..The disease spreads from the vulva through embolization to the locoregional lymphatic station, the inguinofemoral nodes. The single most important prognostic factor is the presence or absence of nodal disease...
  42. pmc Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2
    Shehnaz K Hussain
    Program in Epidemiology, Division of Public Health Sciences, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 17:1790-9. 2008
    ..87; 95% CI, 1.00-3.48), and for carriership of the TTCC/TTCC diplotype (IOR, 2.08; 95% CI, 1.01-4.30). These results suggest that cervical and vulvar SCC risk among cigarette smokers is modified by genetic variation in IL2...
  43. ncbi The simplex (differentiated) variant of vulvar intraepithelial neoplasia
    Meng Yueh Hsieh
    Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Dermatol Surg 30:948-51. 2004
    ..It is regarded as more likely than "classic" carcinoma in situ to be associated with invasion and can be easily mistaken for benign lesions...
  44. ncbi Vulvar cancer patients' quality of life: a qualitative assessment
    M Janda
    Centre for Public Health Research, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Int J Gynecol Cancer 14:875-81. 2004
    ..Results of this study revealed vulvar cancer-specific reductions in QOL for inclusion in the newly developed vulvar cancer-specific subscale...
  45. ncbi Surgery and radiotherapy in vulvar cancer
    J A de Hullu
    Department of Gynaecologic Oncology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Crit Rev Oncol Hematol 60:38-58. 2006
    ....
  46. doi Current controversies in the management of patients with early-stage vulvar cancer
    Maaike H M Oonk
    Department of Gynecologic Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Oncol 22:481-6. 2010
    ..The main focus will be on the procedures for assessing the sentinel node and the treatment of those with evidence of metastatic involvement...
  47. doi Differentiated-type vulval intraepithelial neoplasia has a high-risk association with vulval squamous cell carcinoma
    Lois J Eva
    Pan Birmingham Cancer Centre, Birmingham, UK
    Int J Gynecol Cancer 19:741-4. 2009
    ..To assess the potential malignant risk of vulval premalignant conditions, in particular, to investigate whether there is a difference in the cancer risk between women with the 2 types of vulval intraepithelial neoplasia (VIN)...
  48. ncbi The use of cytospin monolayer technique in the cytological diagnosis of vulval and anal disease
    T S Levine
    Department of Histopathology and Cytopathology, The Royal Free Hospital NHS Trust, London, UK
    Cytopathology 12:297-305. 2001
    ..The cytospin monolayer technique allows the diagnosis of neoplastic from non-neoplastic vulval disease. It is a quick, inexpensive and non-invasive method that may have a role in diagnosis, screening and surveillance of patients...
  49. doi Specific intraepithelial localization of mast cells in differentiated vulvar intraepithelial neoplasia and its possible contribution to vulvar squamous cell carcinoma development
    Hedwig P van de Nieuwenhof
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 57:351-62. 2010
    ....
  50. ncbi Groin recurrence in carcinoma of the vulva: management and outcome
    G Cormio
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Bari, Bari, Italy
    Eur J Cancer Care (Engl) 19:302-7. 2010
    ..Groin recurrences from vulvar carcinoma carry a poor prognosis. Multi-modal treatment may result in a palliation of the disease, and a very limited number of patients have long-term survival...
  51. doi Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma
    Hedwig P van de Nieuwenhof
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, The Netherlands
    Mod Pathol 24:297-305. 2011
    ..Patients with lichen sclerosus with dyskeratosis and parakeratosis, hyperplasia and/or basal cellular atypia should be kept under close surveillance as these lesions also tend to progress to squamous cell carcinoma...
  52. pmc Human papillomavirus 16-specific T cell responses in classic HPV-related vulvar intra-epithelial neoplasia. Determination of strongly immunogenic regions from E6 and E7 proteins
    I Bourgault Villada
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Departement d Immunologie, Hopital Cochin, Paris, France
    Clin Exp Immunol 159:45-56. 2010
    ..In order to build a therapeutic anti-HPV-16 vaccine, E6/2 (14-34) and E6/4 (45-68) fragments thus appear to be good candidates to increase HPV-specific effector T lymphocyte responses and clear classic VIN (BP) disease lesions...
  53. ncbi Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study
    Maaike H Oonk
    University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lancet Oncol 11:646-52. 2010
    ..Our study aimed to assess the association between size of sentinel-node metastasis and risk of metastases in non-sentinel nodes, and risk of disease-specific survival in early stage vulvar cancer...
  54. doi Outcome and patterns of recurrence for International Federation of Gynecology and Obstetrics (FIGO) stages I and II squamous cell vulvar cancer
    Charuwan Tantipalakorn
    Gynaecological Cancer Centre, Royal Hospital for Women and University of New South Wales, Sydney, Australia
    Obstet Gynecol 113:895-901. 2009
    ....
  55. ncbi Primary ectopic breast cancer presenting as a vulvar mass
    Gilberto Lopes
    Department of Oncology, Johns Hopkins Singapore International Medical Center, Singapore
    Clin Breast Cancer 7:278-9. 2006
    ..Its treatment usually entails surgical resection with lymph node dissection. Adjuvant therapy should be guided by the same principles as in orthotopic breast carcinoma...
  56. doi The accuracy of the sentinel lymph node concept in early stage squamous cell vulvar carcinoma
    Jakub Radziszewski
    Department of Brachytherapy, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland
    Gynecol Oncol 116:473-7. 2010
    ..The purpose of the study was to determine the feasibility and accuracy of the sentinel lymph node (SLN) identification in vulvar carcinoma patients...
  57. ncbi Sparing of saphenous vein during inguinal lymphadenectomy for vulval malignancies
    Xiaoling Zhang
    Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, 250117, Shandong, PR China
    Gynecol Oncol 105:722-6. 2007
    ..This work was set out to investigate the effect of saphenous vein preservation during inguinal lymphadenectomy for patients with vulval malignancies...
  58. doi Gynaecologic cancer complicating pregnancy: an overview
    Frederic Amant
    Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 24:61-79. 2010
    ..Firstly, we describe general diagnostic and cancer-treatment-related problems. In the second part, organ pathology including breast, cervical, ovarian, endometrial and vulvar cancer is discussed...
  59. ncbi Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Gynecol Oncol 100:271-5. 2006
    ..To evaluate various treatment modalities for vulvar intraepithelial neoplasia (VIN) in relation to possible risk factors for recurrence...
  60. ncbi Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination
    Petr Skapa
    Department of Pathology and Molecular Medicine, Charles University, 2nd Medical School, Faculty Hospital Motol, Prague, Czech Republic
    Am J Surg Pathol 31:1834-43. 2007
    ....
  61. ncbi Predictors of complications after inguinal lymphadenectomy
    N Gould
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Gynecol Oncol 82:329-32. 2001
    ..CONCLUSIONS: Chronic lymphedema occurs in nearly 30% of patients after LND. Late complications after LND were not predicted by early complications. New strategies for prevention of chronic lymphedema are needed...
  62. ncbi Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women
    E A Joura
    Department of Gynecology and Obstetrics, University of Vienna, Austria
    J Reprod Med 45:613-5. 2000
    ..To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade...
  63. ncbi Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways
    I A M van der Avoort
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Gynecol Pathol 25:22-9. 2006
    ..First, an HPV-dependent pathway with a remarkable resemblance to CIN lesions and cervical carcinoma and second, an HPV-independent pathway in which differentiated VIN III lesions that are hr-HPV-negative may be precursors...
  64. doi Treatment of vulvar intraepithelial neoplasia with topical imiquimod
    Manon van Seters
    Department of Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:1465-73. 2008
    ..Alternatives to surgery are needed for the treatment of vulvar intraepithelial neoplasia. We investigated the effectiveness of imiquimod 5% cream, a topical immune-response modulator, for the treatment of this condition...
  65. doi Human papillomavirus infections and vulvar disease development
    Suzanne M Garland
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical University of Vienna, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
    Cancer Epidemiol Biomarkers Prev 18:1777-84. 2009
    ....
  66. ncbi Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee
    Mario Sideri
    European Institute of Oncology, Milan, Italy
    J Reprod Med 50:807-10. 2005
    ..The term VIN 1 will no longer be used. Two categories should describe squamous VIN: VIN, usual type (encompassing former VIN 2 and 3 of warty, basaloid and mixed types) and VIN, differentiated type (VIN 3, differentiated type)...
  67. ncbi Genetic abnormalities and HPV status in cervical and vulvar squamous cell carcinomas
    Fung Yu Huang
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 6 F, Professorial Block, Pokfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 157:42-8. 2005
    ....
  68. ncbi EGFR expression is associated with groin node metastases in vulvar cancer, but does not improve their prediction
    M H M Oonk
    Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700RB Groningen, The Netherlands
    Gynecol Oncol 104:109-13. 2007
    ..Aim of the study was to evaluate whether in addition to 'classic' clinicopathological factors determination of EGFR expression in vulvar cancer can be helpful in defining such a 'low-risk' group...
  69. ncbi Occult lymph node metastases in early stage vulvar carcinoma patients
    Synne Knopp
    Department of Pathology, University of Oslo, Faculty Division, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Gynecol Oncol 99:383-7. 2005
    ....
  70. ncbi Squamous cell carcinoma antigen serum levels as prognostic parameter in patients with early stage vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 97:904-7. 2005
    ..To determine whether SCC-Ag serum levels can be used as a prognostic parameter in surgically treated early stage vulvar cancer...
  71. ncbi Cyclins D1, D3, E, and A in vulvar carcinoma patients
    Synne Knopp
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Gynecol Oncol 97:733-9. 2005
    ..The aim of this study was to characterize the expression of cyclins D1, D3, E, and A in a comparatively large series of patients with vulvar squamous cell carcinoma and look for prognostic impact...
  72. ncbi Prognostic significance of epithelial disorders adjacent to invasive vulvar carcinomas
    R Rouzier
    Department of Gynecologic Surgery, Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif Cedex, 94805, France
    Gynecol Oncol 81:414-9. 2001
    ..CONCLUSION: The results of this study support the view that histological evidence of epithelial alterations adjacent to invasive carcinoma can serve to separate patients that differ in terms of prognosis...
  73. ncbi High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia
    Frederic Goffin
    Département d Obstétrique, Pathologie et Microbiologie Infectiologie, Hôpital Notre Dame Centre Hospitalier de l Université de Montréal, CHUM, Montreal, Quebec, Canada
    J Med Virol 78:814-9. 2006
    ..2). Multifocal vulvar HPV infection was detected in women with previous or active VIN-3. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN-3...
  74. ncbi Outcomes for patients with T1 squamous cell cancer of the vulva undergoing sentinel node biopsy
    Keith Y Terada
    Department of Obstetrics and Gynecology, University of Hawaii School of Medicine, Honolulu, HI 96822, USA
    Gynecol Oncol 102:200-3. 2006
    ..This retrospective review was undertaken to evaluate survival in patients with T1 squamous cell carcinoma of the vulva treated with radical local excision and sentinel node dissection...
  75. ncbi New and surprising insights into pathogenesis of multicentric squamous cancers in the female lower genital tract
    Qinghua Feng
    J Natl Cancer Inst 97:1798-9. 2005
  76. ncbi Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women
    Ronald W Jones
    Vulvar Clinic, Department of Gynecologic Oncology, National Women s Hospital, Auckland, New Zealand
    Obstet Gynecol 106:1319-26. 2005
    ..To determine the clinical characteristics, outcome following surgical treatment, and natural history of cases of untreated vulvar intraepithelial neoplasia (VIN)...
  77. ncbi Prediction of lymph node metastases in vulvar cancer: a review
    M H M Oonk
    Department of Gynaecologic Oncology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Int J Gynecol Cancer 16:963-71. 2006
    ..The minimally invasive sentinel node procedure is a promising technique for selecting patients for complete lymphadenectomy, but its safety has not been proven yet...
  78. ncbi Increased angiogenesis is associated with poor prognosis of squamous cell carcinoma of the vulva
    Veera V Näyhä
    Department of Pathology, University of Oulu, Oulu, Finland
    Acta Obstet Gynecol Scand 86:1392-7. 2007
    ..Increased angiogenesis is associated with an increased risk of malignant transformation in many organs. The occurrence, characteristics and significance of angiogenesis in vulvar squamous cell carcinoma are less well known...
  79. ncbi Sentinel node dissection in vulvar cancer
    Amy A Hakim
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, Suite 420, 333 East Superior Street, Chicago, IL 60611, USA
    Curr Treat Options Oncol 7:85-91. 2006
    ..Patients with positive sentinel nodes may then undergo additional therapy. Patients with negative sentinel nodes are theoretically at very low risk for metastases and should not require any additional treatment...
  80. ncbi p14ARF, a prognostic predictor in HPV-negative vulvar carcinoma
    Synne Knopp
    Department of Pathology, and the University of Oslo, Faculty Division, the Norwegian Radium, Hospital, Oslo, Norway
    Am J Clin Pathol 126:266-76. 2006
    ..In patients with HPV- tumors expressing high levels of p53, low p14 indicated the poorest 5-year disease-specific survival...
  81. ncbi Sentinel lymph node in vulvar cancer
    Jan Hauspy
    Division of Gynecologic Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Cancer 110:1015-23. 2007
    ..The aim of the study was to assess the feasibility, efficacy, and accuracy of the sentinel lymph node (SLN) procedure in vulvar cancer...
  82. ncbi Intratumoral oxygenation of invasive squamous cell carcimoma of the vulva is not correlated with regional lymph node metastasis
    J E Stone
    Department of Gynecology, Department of Gynecologic Oncology, University of British Columbia, Vancouver
    Eur J Gynaecol Oncol 26:31-5. 2005
    ..Our secondary objective was to assess if there was a relationship between the clinical and biological variables...
  83. pmc The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva
    G V Narayansingh
    Gynaecology Oncology Unit, Ward 43, Aberdeen Royal Infirmary, AB25 2ZN, UK
    Br J Cancer 92:222-4. 2005
    ..In total, 13 women (42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20-fold higher in those with micrometastases compared to those without (hazard ratio=19.6 (95% CI 2.3-171)...
  84. ncbi Clinicopathologic comparison of vulvar and extragenital lichen sclerosus: histologic variants, evolving lesions, and etiology of 141 cases
    J A Carlson
    Division of Dermatopathology and Dermatology, Albany Medical College, New York 12208, USA
    Mod Pathol 11:844-54. 1998
    ....
  85. ncbi Small vulvar squamous cell carcinomas and adjacent tissues. A morphologic study
    Hemming Poulsen
    Department of Pathology, Hvidovre University Hospital, Institute of Pathology, Herlev University Hospital, Denmark
    APMIS 111:835-42. 2003
    ..Five of these cases were incompletely surrounded by varying degrees of dysplasia, mainly VIN2 and VIN3. Two different pathogenetic pathways for the development of vulvar squamous cell carcinoma are likely...
  86. ncbi A review of molecular pathological markers in vulvar carcinoma: lack of application in clinical practice
    S Knopp
    Division of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    J Clin Pathol 62:212-8. 2009
    ..Therefore, the investigated markers have not yet earned a place in standard clinical diagnostics or treatment, and further studies are needed to clarify the clinical value of these markers...
  87. ncbi Invasive mucinous (colloid) adenocarcinoma of ectopic breast tissue in the vulva: a case report
    C Yin
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    Breast J 9:113-5. 2003
    ..The tumor cells were positive for estrogen receptors (ERs), progesterone receptors (PRs), and BRST-1 markers. The clinical and pathologic features, differential diagnosis, and treatment are discussed...
  88. ncbi Further data on the usefulness of sentinel lymph node identification and ultrastaging in vulvar squamous cell carcinoma
    Luis M Puig-Tintore
    Section of Gynecologic Oncology, Institut Clinic de Ginecologia, Obstetricia i Neonatologia ICGON, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Gynecol Oncol 88:29-34. 2003
    ....
  89. ncbi Fibroadenoma of the mammary-like glands of the vulva
    J D Sington
    Histopathology 41:563-5. 2002
  90. ncbi Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review
    Liana Abramova
    Department of Surgery, University of Virginia Health Science Center, Charlottesville, Virginia 22906, USA
    Ann Surg Oncol 9:840-6. 2002
    ..However, prophylactic lymphadenectomy has not been shown to improve survival of melanoma patients. We wanted to determine the feasibility of sentinel lymph node biopsy in patients with female urogenital melanoma as a staging procedure...
  91. ncbi Serum levels of squamous cell carcinoma antigen as a predictor of inguinofemoral lymph node metastasis in patients with vulvar cancer
    Andreas Nather
    Department of Gynecology and Obstetrics, University of Vienna General Hospital, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Reprod Med 47:718-20. 2002
    ..To evaluate the predictive value of preoperatively determined squamous cell carcinoma antigen (SCC-Ag) serum levels for the risk of inguinofemoral lymph node metastasis...
  92. ncbi Pathologic evaluation of inguinal sentinel lymph nodes in vulvar cancer patients: a comparison of immunohistochemical staining versus ultrastaging with hematoxylin and eosin staining
    Richard G Moore
    Program in Women s Oncology, Department of Obstetrics and Gynecology, 101 Dudley Street, Women and Infants Hospital, Brown University, Providence, RI 02905, USA
    Gynecol Oncol 91:378-82. 2003
    ..To evaluate the value of immunohistochemical (IHC) staining of inguinal sentinel lymph nodes (SLN) found to be negative for metastatic disease by ultrastaging with hematoxylin and eosin (H&E) staining...
  93. ncbi Lymphatic mapping of sentinel nodes in early vulvar cancer
    G Sliutz
    Department of Gynecology, University of Vienna, Vienna, A 1090, Austria
    Gynecol Oncol 84:449-52. 2002
    ..The aim of the study was to determine the diagnostic accuracy and feasibility of sentinel lymph node (SLN) detection using a gamma probe in patients suffering from vulvar cancer...
  94. ncbi Sentinel lymph node detection and microstaging in vulvar carcinoma
    K L Molpus
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198 3255, USA
    J Reprod Med 46:863-9. 2001
    ..To determine the efficacy of using complementary techniques for detecting sentinel lymph nodes (SLNs) in vulvar carcinoma and to evaluate the utility of microstaging techniques...
  95. ncbi Vulvar intraepithelial neoplasia: historical aspects and current status
    W R Hart
    Division of Pathology and Laboratory Medicine (L21, The Cleveland Clinic Foundation, 9500 Euclid Avenue Cleveland, Ohio 44195, USA
    Int J Gynecol Pathol 20:16-30. 2001
    ..This manuscript summarizes the historical development and current status of our knowledge about VIN. Information on the clinical and pathologic aspects are detailed and illustrated, as are considerations of differential diagnosis...
  96. ncbi Detection of sentinel nodes by lymphoscintigraphy and gamma probe guided surgery in vulvar neoplasia
    M Sideri
    Division of Gynecology, European Institute of Oncology, Milan, Italy
    Tumori 86:359-63. 2000
    ..The present study evaluates the feasibility of the surgical identification of inguinal sentinel nodes using lymphoscintigraphy and a gamma detecting probe in patients with early vulvar cancer...
  97. ncbi Recurrent squamous cell carcinoma of the vulva: clinicopathologic determinants identifying low risk patients
    M Preti
    Department of Gynecology and Obstetrics, University of Turin, Turin, Italy
    Cancer 88:1869-76. 2000
    ..The identification of prognostic factors in the recurrence of vulvar squamous cell carcinoma is crucial for less invasive treatments...
  98. pmc Sentinel node biopsy in early vulvar cancer
    C De Cicco
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Br J Cancer 82:295-9. 2000
    ..This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer...
  99. ncbi Serum concentrations of squamous-cell carcinoma antigen and tissue polypeptide antigen in the follow-up of patients with vulvar cancer
    L Hefler
    Department of Gynaecology and Obstetrics, University of Vienna Medical School, Vienna, Austria
    Int J Cancer 83:167-70. 1999
    ..Furthermore, our data indicate that combining SCC-Ag with TPA is not a successful strategy to improve the sensitivity or the duration of lead-time effects in the follow-up of patients with vulvar cancer...
  100. ncbi Vulvar squamous cell carcinoma: guidelines for early diagnosis and treatment
    Stephen K Tyring
    UTMB Center for Clinical Studies, University of Texas Medical Branch, 301 University Boulevard, Route 1070, Galveston, TX 77555, USA
    Am J Obstet Gynecol 189:S17-23. 2003
    ..This review discusses the etiology, clinical characteristics, and diagnostic staging of vulvar SCC. Treatment options are reviewed, including novel topical immunotherapies such as imiquimod...
  101. pmc The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
    Zhihui Wang
    Division of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    BMC Cancer 8:308. 2008
    ..However, the exact role of 14-3-3sigma in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3sigma protein expression is still unknown...

Research Grants48

  1. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2003
    ....
  2. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
    ....
  3. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2004
    ....
  4. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2005
    ....
  5. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2002
    ....
  6. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  8. New Strategies for Photoimmunodetection/therapy
    Mark Savellano; Fiscal Year: 2008
    ..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers. ..
  9. New Strategies for Photoimmunodetection/therapy
    Mark Savellano; Fiscal Year: 2007
    ..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers. ..
  10. Therapeutic HPV vaccination for stage IB1 cervical cancer
    Cornelia Trimble; Fiscal Year: 2008
    ..Clinical grade vaccine has been manufactured by NCI RAID, in collaboration with PowderMed. This trial is a SPORE-GOG collaboration. ..
  11. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. A Molecular Signature of Early Cervical Carcinoma
    Concepcion Diaz Arrastia; Fiscal Year: 2007
    ..I propose to identify a genomic and proteomic signature of cervical cancer that will predict the aggressive behavior of the tumor and function clinically to develop molecular-based treatment plans. ..
  13. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  14. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2007
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  15. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2008
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  17. Effect of Male Circumcision on Penile HPV Infection
    JENNIFER SUSAN SMITH; Fiscal Year: 2010
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  18. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  19. Effect of Male Circumcision on Penile HPV Infection
    Jennifer Smith; Fiscal Year: 2009
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  20. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  21. Mechanisms of mucosal immune evasion in high grade cervical dysplasia
    Cornelia L Trimble; Fiscal Year: 2010
    ....
  22. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2009
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  23. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2009
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  24. Effect of Male Circumcision on Penile HPV Infection
    Jennifer Smith; Fiscal Year: 2009
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  25. Effect of Male Circumcision on Penile HPV Infection
    Jennifer Smith; Fiscal Year: 2008
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  26. Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Alexander Burnett; Fiscal Year: 2007
    ..The pill would have minimal or no side effects and could be available to be taken immediately at the first warning or after announcement of a nuclear explosion. [unreadable] [unreadable] [unreadable]..
  27. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2007
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  28. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  30. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2004
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  31. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2004
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  32. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  33. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2001
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  34. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2003
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  35. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2003
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  36. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2002
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  37. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2004
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  38. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  39. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2005
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  40. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2006
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  41. Effect of Male Circumcision on Penile HPV Infection
    Jennifer Smith; Fiscal Year: 2006
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  42. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2006
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  43. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2006
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  44. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2006
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  45. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2005
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  46. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2005
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  47. Effect of Male Circumcision on Penile HPV Infection
    Jennifer Smith; Fiscal Year: 2005
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  48. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2002
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..