endometriosis

Summary

Summary: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.

Top Publications

  1. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
  2. pmc ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
  3. ncbi Endometriosis
    Linda C Giudice
    Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproduction, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Lancet 364:1789-99. 2004
  4. ncbi ESHRE guideline for the diagnosis and treatment of endometriosis
    Stephen Kennedy
    University of Oxford, UK
    Hum Reprod 20:2698-704. 2005
  5. doi Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Mol Endocrinol 22:2557-62. 2008
  6. pmc Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
    Pamela Stratton
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bldg 10, CRC, Rm 1 3140, 10 Center Dr MSC 1109, Bethesda, MD 20892 1109 USA
    Hum Reprod Update 17:327-46. 2011
  7. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
  8. pmc Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Lancet Oncol 13:385-94. 2012
  9. ncbi Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:681-7. 2007
  10. ncbi Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis
    Yan Wu
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Epigenetics 1:106-11. 2006

Research Grants

  1. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
  2. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
  3. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
  4. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  6. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
  7. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  8. Cooperative Multicenter Reproductive Medicine Network (U10)
    Gregory Christman; Fiscal Year: 2007
  9. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
  10. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007

Detail Information

Publications259 found, 100 shown here

  1. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
    To establish the use of aromatase inhibitors as a therapeutic option for endometriosis.
  2. pmc ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
    Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described.
  3. ncbi Endometriosis
    Linda C Giudice
    Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproduction, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Lancet 364:1789-99. 2004
    b>Endometriosis is an oestrogen-dependent disorder that can result in substantial morbidity, including pelvic pain, multiple operations, and infertility...
  4. ncbi ESHRE guideline for the diagnosis and treatment of endometriosis
    Stephen Kennedy
    University of Oxford, UK
    Hum Reprod 20:2698-704. 2005
    The objective was to develop recommendations for the diagnosis and treatment of endometriosis and its associated symptoms...
  5. doi Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Mol Endocrinol 22:2557-62. 2008
    b>Endometriosis is a common gynecological disorder characterized by pain and infertility, where the lesions disseminate everywhere in the body with a preference for the pelvis...
  6. pmc Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
    Pamela Stratton
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bldg 10, CRC, Rm 1 3140, 10 Center Dr MSC 1109, Bethesda, MD 20892 1109 USA
    Hum Reprod Update 17:327-46. 2011
    Many clinicians and patients believe that endometriosis-associated pain is due to the lesions...
  7. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
    ..Our aim was to identify specific miRNAs that are expressed in endometrium of women with and without endometriosis. We profiled the expression of 287 miRNAs in paired eutopic and ectopic endometrium and isolated endometrial ..
  8. pmc Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Lancet Oncol 13:385-94. 2012
    b>Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear...
  9. ncbi Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:681-7. 2007
    Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles...
  10. ncbi Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis
    Yan Wu
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Epigenetics 1:106-11. 2006
    ..Progestins have long been used in the treatment of endometriosis but unfortunately the relief of pain is relatively short-term...
  11. ncbi Oxidative stress may be a piece in the endometriosis puzzle
    Małgorzata Szczepańska
    Department of Gynecology and Obstetrics, Division of Reproduction, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    Fertil Steril 79:1288-93. 2003
    To assess the total antioxidant potential of women with endometriosis-associated infertility, women with idiopathic infertility, and fertile controls.
  12. doi Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology
    Tetsuo Maruyama
    Department of Obstetrics and Gynaecology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Reproduction 140:11-22. 2010
    ..We also propose a novel hypothetical model in which stem cell activities explain the physiological remodelling and regeneration of the human uterus and the pathogenesis of gynaecological diseases such as endometriosis.
  13. ncbi The pains of endometriosis
    Karen J Berkley
    Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA
    Science 308:1587-9. 2005
    b>Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production...
  14. pmc Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts
    K Huhtinen
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Br J Cancer 100:1315-9. 2009
    ..concentrations together with a tumour marker CA125 in serum samples of women diagnosed with various types of endometriosis, endometrial cancer or ovarian cancer, and in samples from healthy controls...
  15. doi Endometriosis and mechanisms of pelvic pain
    Fred M Howard
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Minim Invasive Gynecol 16:540-50. 2009
    b>Endometriosis remains an enigmatic disorder in that the cause, the natural history, and the precise mechanisms by which it causes pain are not completely understood...
  16. pmc Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium
    Banghyun Lee
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 80:79-85. 2009
    The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene expression...
  17. doi Endometriosis and infertility: pathophysiology and management
    Dominique DE Ziegler
    Universite Paris Descartes, Centre Hospitalier Universitaire Cochin, Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Paris, France
    Lancet 376:730-8. 2010
    b>Endometriosis and infertility are associated clinically. Medical and surgical treatments for endometriosis have different effects on a woman's chances of conception, either spontaneously or via assisted reproductive technologies (ART)...
  18. pmc Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    b>Endometriosis is a common gynecological disease associated with pelvic pain and subfertility...
  19. doi Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress
    Ken Yamaguchi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 14:32-40. 2008
    ....
  20. ncbi The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial
    Seyide Soysal
    Department of Obstetrics and Gynecology, Pamukkale University Medical Center, 20100 Denizli, Turkey
    Hum Reprod 19:160-7. 2004
    Among patients using GnRH analogues for endometriosis it has been postulated that peripheral and inflammation-induced in-situ aromatization of adrenal androgens are probably the main reasons for the high rates of failure during follow-up...
  21. doi Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management
    Masaki Mandai
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Int J Clin Oncol 14:383-91. 2009
    Recent molecular and pathological evidence suggests that endometriosis is a monoclonal, neoplastic disease...
  22. pmc The search for genes contributing to endometriosis risk
    Grant W Montgomery
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
    Hum Reprod Update 14:447-57. 2008
    Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies.
  23. ncbi Contribution of bone marrow-derived stem cells to endometrium and endometriosis
    Hongling DU
    Division of Reproductive Endocrinology, Department of Medicine, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Stem Cells 25:2082-6. 2007
    ..We investigate whether BMDCs can localize to uterine endometrium and to endometriosis. After bone marrow transplantation, male donor-derived bone marrow cells were found in the uterine endometrium ..
  24. ncbi Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    Richard O Burney
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Endocrinology 148:3814-26. 2007
    The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and toward developing novel strategies for the treatment of ..
  25. doi A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese
    Satoko Uno
    Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:707-10. 2010
    Although the pathogenesis of endometriosis is not well understood, genetic factors have been considered to have critical roles in its etiology...
  26. pmc Functional microRNA involved in endometriosis
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Drive, Suite 1100, Houston, Texas 77030, USA
    Mol Endocrinol 25:821-32. 2011
    b>Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility...
  27. doi MicroRNA-regulated pathways associated with endometriosis
    E Maria C Ohlsson Teague
    Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Mol Endocrinol 23:265-75. 2009
    b>Endometriosis is a prevalent gynecological disease characterized by growth of endometriotic tissue outside the uterine cavity...
  28. pmc Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis
    Christian M Becker
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:1782-91. 2011
    b>Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions...
  29. doi Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70
    Khaleque Newaz Khan
    Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Hum Reprod 23:2210-9. 2008
    We investigated the role of human heat-shock protein 70 (Hsp70) in Toll-like receptor 4 (TLR4)-mediated growth of endometriosis.
  30. doi L-carnitine supplementation reduces oocyte cytoskeleton damage and embryo apoptosis induced by incubation in peritoneal fluid from patients with endometriosis
    Gihan Mansour
    Reproductive Research Center, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio, USA
    Fertil Steril 91:2079-86. 2009
    To investigate the protective effect of L-carnitine (LC) against deleterious substances present in the peritoneal fluid (PF) of patients with endometriosis, which may affect the oocyte cytoskeleton and embryogenesis.
  31. pmc Reactive oxygen species controls endometriosis progression
    Charlotte Ngo
    Faculte de Medecine, Service de Gynécologie Obstétrique II et Médecine de la Reproduction, AP HP Hôpital Cochin, Paris, France
    Am J Pathol 175:225-34. 2009
    b>Endometriosis is associated with chronic inflammation, and reactive oxygen species (ROS) are proinflammatory mediators that modulate cell proliferation...
  32. doi New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal
    Hirotaka Kajihara
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Gynecol Endocrinol 27:73-9. 2011
    Various theories try to explain the development and progression of endometriosis, however, no single theory can explain all aspects of this disorder...
  33. doi Is aromatase expression in the endometrium the cause of endometriosis and related infertility?
    Hugo Maia
    Centro de Pesquisas e Assistencia em Reproducao Humana CEPARH, Bahia, Brazil
    Gynecol Endocrinol 25:253-7. 2009
    ..in doses that do not block ovulation is associated with the occurrence of pregnancy in patients with severe endometriosis without the need for surgery...
  34. pmc Non-dioxin-like polychlorinated biphenyls and risk of endometriosis
    Britton Trabert
    University of Washington, Seattle, Washington, USA
    Environ Health Perspect 118:1280-5. 2010
    b>Endometriosis, a gynecologic disorder affecting 8-10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility...
  35. doi Quantitative and qualitative peritoneal immune profiles, T-cell apoptosis and oxidative stress-associated characteristics in women with minimal and mild endometriosis
    Jennifer Mier-Cabrera
    Departamento de Investigación en Nutrición, Subdirección de Investigación en Salud Pública, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    BJOG 118:6-16. 2011
    To assess immunological variables, T-cell apoptosis and oxidative stress markers in the peripheral blood and peritoneal fluid of women with (WEN) and without (WWE) endometriosis.
  36. doi Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
    b>Endometriosis is a chronic disease that affects millions of reproductive-age women...
  37. doi Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis
    Jozef Hatok
    Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovak Republic
    Gynecol Endocrinol 27:331-6. 2011
    b>Endometriosis (ENDs) and adenomyosis (ADNs) are estrogen-dependent diseases...
  38. pmc MGEx-Udb: a mammalian uterus database for expression-based cataloguing of genes across conditions, including endometriosis and cervical cancer
    Akhilesh K Bajpai
    Institute of Bioinformatics and Applied Biotechnology IBAB, Bengaluru Bangalore, Karnataka State, India
    PLoS ONE 7:e36776. 2012
    ..Gene expression profiling of uterus tissue has been performed in various contexts, but a significant amount of the data remains underutilized as it is not covered by the existing general resources...
  39. pmc Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:36-43. 2010
    Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease...
  40. ncbi The role of endometrium in endometriosis
    Murat Ulukus
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
    J Soc Gynecol Investig 13:467-76. 2006
    b>Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. Several theories have been proposed to explain the pathogenesis of this disease...
  41. doi Pain and ovarian endometrioma recurrence after laparoscopic treatment of endometriosis: a long-term prospective study
    Maria Grazia Porpora
    Department of Gynecology and Obstetrics, University of Rome Sapienza, Viale Regina Elena, 324 00161 Rome, Italy
    Fertil Steril 93:716-21. 2010
    ..To identify prognostic factors for pain and endometrioma recurrence after complete laparoscopic excision of endometrioma(s)...
  42. ncbi Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis
    Yan Wu
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Fertil Steril 87:24-32. 2007
    Since endometriosis is a persistent disease with substantial gene dysregulation, there must be cellular memory of some sort that constitutes a unique cell identity for endometriotic cells...
  43. pmc Molecular evidence for differences in endometrium in severe versus mild endometriosis
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco UCSF, San Francisco, CA 94143, USA
    Reprod Sci 18:229-51. 2011
    Women with stage III/IV versus stage I/II endometriosis have lower implantation and pregnancy rates in natural and assisted reproduction cycles...
  44. doi Vasculogenesis: a new piece of the endometriosis puzzle
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Hum Reprod Update 17:628-36. 2011
    BACKGROUND; Endometriosis is a complex disease with a multifactorial pathogenesis, which is crucially dependent on the development of new blood vessels...
  45. ncbi Apoptosis and endometriosis
    Tasuku Harada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Front Biosci 12:3140-51. 2007
    ..Eutopic endometrium from women with endometriosis reportedly has some fundamental differences compared with normal endometrium of women without endometriosis...
  46. doi The role of the oxidative-stress in the endometriosis-related infertility
    Areti Augoulea
    2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University Medical School, Athens, Greece
    Gynecol Endocrinol 25:75-81. 2009
    b>Endometriosis is a common gynecological disorder of the reproductive age characterised by pelvic pain, dysmenorrhea and infertility. Classic theories have failed to propose a precise pathogenetic mechanism...
  47. doi Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis
    Marc Bazot
    Services de Radiologie, Hopital Tenon, Paris, France
    Fertil Steril 92:1825-33. 2009
    To compare the value of physical examination, transvaginal sonography (TVS), rectal endoscopic sonography (RES), and magnetic resonance imaging (MRI) for the assessment of different locations of deep infiltrating endometriosis (DIE).
  48. ncbi Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part II: pathological results
    Ludovico Muzii
    Department of Obstetrics and Gynaecology, University Campus Bio Medico of Rome, Via Longoni 83, Rome 00155, Italy
    Hum Reprod 20:1987-92. 2005
    ..The objective of this trial was to evaluate the presence and nature of ovarian tissue adjacent to the endometrioma cyst wall obtained by stripping with different techniques...
  49. ncbi Migraine is associated with menorrhagia and endometriosis
    Gretchen E Tietjen
    Department of Neurology, Medical College of Ohio, Toledo 43614, USA
    Headache 46:422-8. 2006
    To evaluate the frequency of menorrhagia and endometriosis in female migraineurs compared to age-matched women without headache.
  50. doi Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
    N Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 191:217-26. 2011
    b>Endometriosis is a very common disease that is characterized by increased formation of estradiol and disturbed progesterone action...
  51. doi Endometriosis and infertility
    Kristin J Holoch
    Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, South Carolina 29605, USA
    Clin Obstet Gynecol 53:429-38. 2010
    b>Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Up to 50% of women with endometriosis are infertile, and agreement about treatment options has been difficult to establish...
  52. pmc Inflammatory status influences aromatase and steroid receptor expression in endometriosis
    Orhan Bukulmez
    Department of Obstetrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9032, USA
    Endocrinology 149:1190-204. 2008
    Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with endometriosis has been reported. Aromatase induction may be mediated by increased cyclooxygenase-2 (COX-2)...
  53. doi Letrozole and norethisterone acetate in colorectal endometriosis
    Simone Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
    Eur J Obstet Gynecol Reprod Biol 150:199-202. 2010
    Up to now limited attention has been given to the medical treatment of bowel endometriosis. This study evaluates the efficacy of aromatase inhibitors and norethisterone acetate in treating pain and gastrointestinal symptoms caused by ..
  54. doi Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis
    S Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Largo R Benzi 1 16132, Genoa, Italy
    Hum Reprod 24:3033-41. 2009
    The available data on effectiveness of aromatase inhibitors in treating pain symptoms related to endometriosis is limited...
  55. doi Haplotype analysis of the matrix metalloproteinase-9 gene associated with advanced-stage endometriosis
    You Jung Han
    Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, South Korea
    Fertil Steril 91:2324-30. 2009
    To investigate whether the -1562C>T, R279Q, P574R, and R668Q polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene are related to endometriosis.
  56. doi Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium
    Ruthy Shaco-Levy
    Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Beer Sheva, Israel
    Eur J Obstet Gynecol Reprod Biol 139:226-32. 2008
    b>Endometriosis and endometrial endometrioid carcinoma are both capable of invasion and metastasis, but their biological behavior is strikingly different...
  57. ncbi Aromatase inhibitors in the treatment of severe endometriosis
    Noha A Mousa
    Institute of Medical Science, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Obstet Gynecol 109:1421-3. 2007
    b>Endometriosis-associated chronic pelvic pain unresponsive to surgical menopause is a difficult clinical problem.
  58. ncbi Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis
    Valentino Remorgida
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
    Aust N Z J Obstet Gynaecol 47:222-5. 2007
    It has recently been suggested that aromatase inhibitors may effectively reduce pain symptoms related to the presence of endometriosis both in postmenopausal women and in subjects of reproductive age.
  59. ncbi Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor
    H M Fatemi
    Centre of Reproductive Medicine, AZ VUB, University Hospital, Dutch speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    Reprod Biomed Online 11:455-7. 2005
    ..Medical management of recurrent post-menopausal endometriosis with aromatase inhibitors seems to be an effective alternative treatment to surgery.
  60. ncbi Progesterone resistance in endometriosis: link to failure to metabolize estradiol
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Mol Cell Endocrinol 248:94-103. 2006
    b>Endometriosis is the most common cause of pelvic pain and affects an estimated 5 million women in the US...
  61. ncbi Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis
    M Bazot
    Department of Radiology, Hopital Tenon, Paris, France
    Ultrasound Obstet Gynecol 24:180-5. 2004
    To determine the accuracy of transvaginal sonography (TVS) for the diagnosis of deep pelvic endometriosis.
  62. doi Disturbed estrogen and progesterone action in ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:59-64. 2009
    b>Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion...
  63. ncbi Marked elevation of macrophage migration inhibitory factor in the peritoneal fluid of women with endometriosis
    Rouslan Kats
    Laboratoire d endocrinologie de la reproduction, Centre de Recherche, Pavillon Saint Francois d Assise, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 78:69-76. 2002
    To evaluate the presence of macrophage migration inhibitory factor (MIF) in the peritoneal fluid of normal fertile women and patients with endometriosis and its growth-promoting activity toward human endothelial cells.
  64. ncbi Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Hum Reprod 21:262-8. 2006
    Angiogenesis represents the crucial step in the pathogenesis of endometriosis, because endometriotic lesions require neovascularization to establish, proliferate and invade inside the peritoneal cavity...
  65. pmc Stem cells and the pathogenesis of endometriosis
    Isaac E Sasson
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1127:106-15. 2008
    b>Endometriosis is a common gynecological disorder that is defined by the presence of endometrial tissue outside the uterine cavity. This disease often results in extensive morbidity, including chronic pelvic pain and infertility...
  66. doi Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis--a randomized, double-blind, multicenter, controlled trial
    Tasuku Harada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Fertil Steril 91:675-81. 2009
    To compare the efficacy and safety of dienogest (DNG) with intranasal buserelin acetate (BA) in patients with endometriosis.
  67. ncbi Laboratory testing for endometriosis
    Mohamed A Bedaiwy
    Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, A81, Cleveland, OH 44195, USA
    Clin Chim Acta 340:41-56. 2004
    Typically, endometriosis is diagnosed surgically by laparoscopy. CA-125 is the principal serum marker used in the diagnosis and management of late-stage endometriosis...
  68. doi A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model
    Daniel Escorsim Machado
    Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitária Ilha do Fundão, Rio de Janeiro, Brazil
    Fertil Steril 93:2674-9. 2010
    To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis.
  69. ncbi Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?
    Giuseppe Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Trends Mol Med 9:223-8. 2003
    b>Endometriosis is a chronic inflammatory disease, characterized by implantation and growth of endometrial tissue outside the uterine cavity...
  70. ncbi Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    Molecular abnormalities in the epithelial cells of endometriosis and their relevance to carcinogenesis of the ovary have been well studied...
  71. doi Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
    Eric M Grund
    EMD Serono Research Institute, One Technology Place, Rockland, MA 02190, USA
    Mol Pharmacol 73:1394-404. 2008
    ....
  72. ncbi Angiogenic activity and IL-8 concentrations in peritoneal fluid and sera in endometriosis
    E Barcz
    Ist Department of Obstetrics and Gynecology, The Medical University of Warsaw, Warsaw, Poland
    Int J Gynaecol Obstet 79:229-35. 2002
    ..Angiogenesis is proposed as one of the mechanisms in endometriosis pathogenesis...
  73. ncbi Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study
    Radhika K Ailawadi
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA
    Fertil Steril 81:290-6. 2004
    To determine the role of an aromatase inhibitor, letrozole, in the treatment of reproductive-age women with endometriosis and associated chronic pelvic pain.
  74. ncbi Anti-angiogenic treatment of endometriosis: biochemical aspects
    R N Taylor
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA
    Gynecol Obstet Invest 57:54-6. 2004
  75. doi Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis
    Joanna M Day
    Department of Endocrinology and Metabolic Medicine, Imperial College, London, London W2 1NY, UK
    Endocr Relat Cancer 15:665-92. 2008
    ..of these enzymes for the treatment of steroid-dependent diseases, including breast and prostate cancer, and endometriosis, with demonstrable efficacy in in vivo disease models...
  76. ncbi Health-related quality of life measurement in women with common benign gynecologic conditions: a systematic review
    Georgina L Jones
    Nuffield Department of Obstetrics and Gynaecology and the Health Services Research Unit, Division of Public Health and Primary Health Care, University of Oxford, United Kingdom
    Am J Obstet Gynecol 187:501-11. 2002
    b>Endometriosis, menorrhagia, chronic pelvic pain, and polycystic ovary syndrome are major sources of psychologic morbidity and can negatively affect quality of life...
  77. doi The relationship of endometriosis and ovarian malignancy: a review
    Farr Nezhat
    Department of Obstetrics, Mount Sinai Medical Center, New York, New York 10019, USA
    Fertil Steril 90:1559-70. 2008
    To review the malignant potential of endometriosis based on epidemiologic, histopathologic, and molecular data.
  78. ncbi High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis
    L Cobellis
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Hum Reprod 18:1512-5. 2003
    Emerging evidence suggests a potential role for ubiquitous environmental contaminants in the physiopathology of endometriosis. Di-(2-ethylhexyl)-phthalate (DEHP), the most commonly used plasticizer in flexible polyvinylchloride (PVC) ..
  79. ncbi Fibrinolysis: the key to new pathogenetic mechanisms
    Esther Zorio
    Hospital Universitario La Fe, Centro de Investigacion, Servicio de Cardiología y Servicio de Ginecología Valencia, Spain
    Curr Med Chem 15:923-9. 2008
    ..also involved in physiological processes, and in pathological situations such as thrombosis, arteriosclerosis, endometriosis and cancer...
  80. ncbi Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA
    Am J Obstet Gynecol 191:733-40. 2004
    Women with endometriosis may be at an increased risk of ovarian cancer. It is not known whether reproductive factors that reduce the risk of ovarian cancer in general also reduce risk in women with endometriosis...
  81. ncbi Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution
    Charles Chapron
    Service de Gynécologie Obstérique II, Unité de chirurgie gynécologique, Institut Cochin, IFR, Universite Paris V, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Universitaire Ouest, France
    Hum Reprod 21:1839-45. 2006
    To investigate whether knowledge of the anatomical distribution of histologically proven deeply infiltrating endometriosis (DIE) lesions contributes to understanding the pathogenesis.
  82. ncbi Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:3261-7. 2007
    b>Endometriosis is an estrogen-dependent disease...
  83. ncbi Aberrant integrin expression in the endometrium of women with endometriosis
    B A Lessey
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599
    J Clin Endocrinol Metab 79:643-9. 1994
    ..To investigate the expression of this integrin in women with endometriosis, we assessed the presence of the beta 3-subunit throughout the menstrual cycle in 268 "in-phase" ..
  84. doi Neuroendocrine circuitry and endometriosis: progesterone derivative dampens corticotropin-releasing hormone-induced inflammation by peritoneal cells in vitro
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeuroImmunology, Charite, Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, Berlin, Germany
    J Mol Med (Berl) 88:267-78. 2010
    Clinical symptoms of endometriosis, such as pain and infertility, can be described as persistent stressors...
  85. ncbi Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane
    Annemiek W Nap
    Department of Obstetrics and Gynaecology, Research Institute Growth and Development GROW, Maastricht University and University Hospital, Maastricht, The Netherlands
    Fertil Steril 83:793-5. 2005
    ..the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model...
  86. ncbi The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity
    Kevin S Jackson
    Department of Obstetrics and Gynecology MC808, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Reprod Sci 14:137-50. 2007
    ..receptors (Pgr), and the chaperone immunophilin FKBP52 in the eutopic endometrium in a baboon model of endometriosis during the window of receptivity to determine if their aberrant distribution contributes to reduced fecundity...
  87. doi Impact of GnRH agonist treatment on recurrence of ovarian endometriomas after conservative laparoscopic surgery
    Byung Chul Jee
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea
    Fertil Steril 91:40-5. 2009
    ..To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment...
  88. doi Endometriosis and infertility: epidemiology and evidence-based treatments
    Sebiha Ozkan
    Department of Obstetrics and Gynecology, Kocaeli University School of Mediine, Kocaeli, Turkey
    Ann N Y Acad Sci 1127:92-100. 2008
    b>Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0...
  89. ncbi Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease
    Marc Bazot
    Department of Radiology, Hopital Tenon, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, Paris 75020, France
    Radiology 232:379-89. 2004
    To prospectively evaluate the accuracy of magnetic resonance (MR) imaging for the preoperative diagnosis of deep pelvic endometriosis and extension of the disease.
  90. ncbi Proteomic approaches in endometriosis research
    Anne E Poliness
    Departments of Perinatal Medicine and Gynaecology, The Royal Women s Hospital, 132 Grattan Street, Carlton, Melbourne 3053, Australia
    Proteomics 4:1897-902. 2004
    To date, the quest to develop a noninvasive diagnostic test for endometriosis has mostly concentrated on the levels of cytokines and growth factors that are involved in inflammation, angioneogenesis and tissue remodeling, present in ..
  91. ncbi High-dose pilot study with the novel progestogen dienogestin patients with endometriosis
    A E Schindler
    Department of Gynecology and Obstetrics, University of Essen, Essen, Germany
    Gynecol Endocrinol 22:9-17. 2006
    High-dose dienogest (20 mg/day) was used for the treatment of endometriosis in women aged 18-52 years after laparoscopic and histological diagnosis of endometriosis and staging according to the revised American Fertility Society criteria...
  92. ncbi Increased frequency of migraine among women with endometriosis
    S Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R Benzi 1, 16132 Genoa, Italy
    Hum Reprod 19:2927-32. 2004
    Our aim is to assess the prevalence and characteristics of headache in patients with endometriosis compared with women without this disease.
  93. doi Use of the SF-36 questionnaire to predict quality-of-life improvement after laparoscopic colorectal resection for endometriosis
    G Dubernard
    Department of Obstetrics and Gynecology, Hopital Tenon, AP HP, Universite Pierre et Marie Curie Paris VI, 4 rue de Chine, 75020 Paris, France
    Hum Reprod 23:846-51. 2008
    Laparoscopic colorectal resection for endometriosis can improve quality of life (QOL), but the results vary widely from one woman to another...
  94. doi Laparoscopic colorectal resection for bowel endometriosis: feasibility, complications, and clinical outcome
    Luca Minelli
    Department of Obstetrics and Gynecology, Ospedale Sacro Cuore, Negrar, Italy
    Arch Surg 144:234-9; discussion 239. 2009
    To evaluate the short- and long-term outcomes of laparoscopic colorectal resection for endometriosis.
  95. doi Surgical management of deep infiltrating endometriosis of the rectum: pleading for a symptom-guided approach
    Horace Roman
    Department of Gynecology and Obstetrics, Clinique Gynécologique et Obstétricale, Rouen University Hospital, 1 rue de Germont, 76031 Rouen, France
    Hum Reprod 26:274-81. 2011
    Two surgical approaches are usually employed in the treatment of deep infiltrating endometriosis of the rectum (DIER): colorectal resection removing the rectal segment affected by the disease, and nodule excision either without opening ..
  96. pmc MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility
    Cherry Yin Yi Chang
    Human Genetic Center, China Medical University Hospital, Taichung, Taiwan
    BMC Med 9:19. 2011
    Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown.
  97. ncbi Surgical outcome and long-term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis
    R Seracchioli
    Center of Reconstructive Pelvic Endo surgery, Reproductive Medicine Unit, S Orsola Hospital, University of Bologna, Bologna, Italy
    BJOG 114:889-95. 2007
    ..was to assess the long-term outcome of treating severely symptomatic women with deep infiltrating intestinal endometriosis by laparoscopic segmental rectosigmoid resection...
  98. ncbi Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrasov trg 2, 1000 Ljubljana, Slovenia
    Gynecol Endocrinol 23:105-11. 2007
    b>Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites, and it is well known that endometriosis is an estrogen-dependent disease...
  99. ncbi Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs.
  100. ncbi Outcome of in vitro fertilization and ovarian response after endometrioma stripping at laparoscopy and laparotomy
    Namik Kemal Duru
    Department of Obstetrics and Gynecology, Gulhane Military Medical Academy GATA School of Medicine, Ankara, Turkey
    J Reprod Med 52:805-9. 2007
    ..To add further data on in vitro fertilization (IVF) outcome and ovarian response after endometrioma stripping via either laparoscopy or laparotomy...
  101. pmc 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis
    Christian M Becker
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Womens Centre Headington, University of Oxford, Oxford, OX3 9DU, UK
    Am J Pathol 172:534-44. 2008
    b>Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years...

Research Grants94

  1. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
    ..Women with the primary diagnosis of endometriosis had fewer eggs retrieved, whereas diagnosis of hernia or varicocele was linked to decreased sperm ..
  2. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
    b>Endometriosis affects 5-10% of reproductive-age women with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility...
  3. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  4. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  6. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  7. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  8. Cooperative Multicenter Reproductive Medicine Network (U10)
    Gregory Christman; Fiscal Year: 2007
    ..experience in areas of interest to the Network including infertility, andrology, abnormal uterine bleeding, endometriosis, leiomyomata uteri, polycystic ovarian syndrome, and assisted reproductive technology...
  9. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  10. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..Epithelial cells trapped in inclusion cysts or deriving from endometriosis may be more susceptible to local or circulating growth factors...
  11. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    b>Endometriosis is a common gynecologic disease affecting up to 10% of reproductive-age women. Despite this high prevalence and the severe symptoms associated with the disease, little is known about the pathogenesis of endometriosis...
  12. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..Yeaman an assistant professor at Dartmouth Medical School (DMS) studies the role of carbohydrate antigens in endometriosis and HIV infection will be combined with that of Drs. William Wade and Bruce Reinhold. Dr...
  13. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    b>Endometriosis is a common gynecologic disease affecting up to 10% of reproductive-age women. Despite this high prevalence and the severe symptoms associated with the disease, little is known about the pathogenesis of endometriosis...
  14. SNP Analysis of Endometriosis Candidate Genes
    Idhaliz Flores; Fiscal Year: 2006
    b>Endometriosis is a poorly understood gynecologic condition defined as the presence of endometrial tissue in the peritoneum, ovaries, and other organs...
  15. FEMALE REPRODUCTIVE OUTCOMES AND TCDD EXPOSURE
    Brenda Eskenazi; Fiscal Year: 2001
    ..of the SWHS was to investigate the relationship of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) and endometriosis in a nested case-control study embedded in a cohort of women exposed to extremely high levels of dioxin as a ..
  16. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 2002
    ..more regular, and shorter cycles--a pattern indicative of greater opportunity for retrograde menstruation and endometriosis, a possible precursor of E/CC cancers...
  17. GONADOTROPIN-RELEASING HORMONE ACTION
    P Conn; Fiscal Year: 2007
    ..Among these are treatments for endometriosis/fibroids, polycystic ovary disease, perimenopause, protection of the ovary and testes (i.e...
  18. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    Approximately one-third of women with chronic pelvic pain have endometriosis. Surgical treatment of endometriosis with laparoscopic excision of implants and lysis of adhesions is often successful in reducing pain in the short term...
  19. Biochemical and pharmacological studies of human membrane progesterone receptors
    Thomas J Lyons; Fiscal Year: 2010
    ..pharmaceutical importance, being most commonly used for birth control and in the treatment of cancer and endometriosis. Traditionally, the biological activity of such molecules has been tested by investigating their effects on ..
  20. ENDOMETRIOSIS :TRADITIONAL MEDICINE VS HORMONE THERAPY
    Richard Hammerschlag; Fiscal Year: 2002
    DESCRIPTION (APPLICANT'S ABSTRACT): Endometriosis is a significant public health problem affecting 10-15% of women of childbearing age, many of whom suffer persistent pelvic pain and infertility...
  21. Biochemical and pharmacological studies of human membrane progesterone receptors
    Thomas J Lyons; Fiscal Year: 2010
    ..pharmaceutical importance, being most commonly used for birth control and in the treatment of cancer and endometriosis. Traditionally, the biological activity of such molecules has been tested by investigating their effects on ..
  22. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..overall goal of this project is to understand the mechanism of action and clinical potential of retinoids in endometriosis. We propose that retinoids play both a causative role in the development of endometriosis and have therapeutic ..
  23. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2001
    b>Endometriosis affects up to 10% of women of reproductive age in the U.S. with chronic pelvic pain, dysmenorrhea, and probable increased risk of infertility...
  24. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..overall goal of this project is to understand the mechanism of action and clinical potential of retinoids in endometriosis. We propose that retinoids play both a causative role in the development of endometriosis and have therapeutic ..