endometriosis

Summary

Summary: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.

Top Publications

  1. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
  2. ncbi Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis
    Paola Vigano
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Hum Reprod Update 12:77-89. 2006
  3. ncbi ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
  4. ncbi Disturbed estrogen and progesterone action in ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:59-64. 2009
  5. ncbi ESHRE guideline for the diagnosis and treatment of endometriosis
    Stephen Kennedy
    University of Oxford, UK
    Hum Reprod 20:2698-704. 2005
  6. ncbi The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial
    Seyide Soysal
    Department of Obstetrics and Gynecology, Pamukkale University Medical Center, 20100 Denizli, Turkey
    Hum Reprod 19:160-7. 2004
  7. ncbi MicroRNA-regulated pathways associated with endometriosis
    E Maria C Ohlsson Teague
    Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Mol Endocrinol 23:265-75. 2009
  8. ncbi Endometriosis and infertility
    Kristin J Holoch
    Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, South Carolina 29605, USA
    Clin Obstet Gynecol 53:429-38. 2010
  9. ncbi Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis
    Marc Bazot
    Services de Radiologie, Hopital Tenon, Paris, France
    Fertil Steril 92:1825-33. 2009
  10. ncbi Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis
    M Bazot
    Department of Radiology, Hopital Tenon, Paris, France
    Ultrasound Obstet Gynecol 24:180-5. 2004

Research Grants

  1. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
  2. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
  3. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
  4. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  6. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
  7. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
  8. Cooperative Multicenter Reproductive Medicine Network (U10)
    Gregory Christman; Fiscal Year: 2007
  9. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
  10. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007

Detail Information

Publications213 found, 100 shown here

  1. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
    OBJECTIVE: To establish the use of aromatase inhibitors as a therapeutic option for endometriosis. DESIGN: Prospective open-label Food and Drug Administration phase 2 trial with Institutional Review Board approval...
  2. ncbi Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis
    Paola Vigano
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Hum Reprod Update 12:77-89. 2006
    Although population-based studies have unequivocally reported an increased risk of ovarian cancer in women with endometriosis, the biological evidence supporting the idea of endometriosis as a preneoplastic condition is scanty and not ..
  3. ncbi ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
    Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described.
  4. ncbi Disturbed estrogen and progesterone action in ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:59-64. 2009
    b>Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion...
  5. ncbi ESHRE guideline for the diagnosis and treatment of endometriosis
    Stephen Kennedy
    University of Oxford, UK
    Hum Reprod 20:2698-704. 2005
    The objective was to develop recommendations for the diagnosis and treatment of endometriosis and its associated symptoms...
  6. ncbi The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial
    Seyide Soysal
    Department of Obstetrics and Gynecology, Pamukkale University Medical Center, 20100 Denizli, Turkey
    Hum Reprod 19:160-7. 2004
    Among patients using GnRH analogues for endometriosis it has been postulated that peripheral and inflammation-induced in-situ aromatization of adrenal androgens are probably the main reasons for the high rates of failure during follow-up...
  7. ncbi MicroRNA-regulated pathways associated with endometriosis
    E Maria C Ohlsson Teague
    Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Mol Endocrinol 23:265-75. 2009
    b>Endometriosis is a prevalent gynecological disease characterized by growth of endometriotic tissue outside the uterine cavity...
  8. ncbi Endometriosis and infertility
    Kristin J Holoch
    Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, South Carolina 29605, USA
    Clin Obstet Gynecol 53:429-38. 2010
    b>Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Up to 50% of women with endometriosis are infertile, and agreement about treatment options has been difficult to establish...
  9. ncbi Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis
    Marc Bazot
    Services de Radiologie, Hopital Tenon, Paris, France
    Fertil Steril 92:1825-33. 2009
    To compare the value of physical examination, transvaginal sonography (TVS), rectal endoscopic sonography (RES), and magnetic resonance imaging (MRI) for the assessment of different locations of deep infiltrating endometriosis (DIE).
  10. ncbi Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis
    M Bazot
    Department of Radiology, Hopital Tenon, Paris, France
    Ultrasound Obstet Gynecol 24:180-5. 2004
    To determine the accuracy of transvaginal sonography (TVS) for the diagnosis of deep pelvic endometriosis.
  11. ncbi Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part II: pathological results
    Ludovico Muzii
    Department of Obstetrics and Gynaecology, University Campus Bio Medico of Rome, Via Longoni 83, Rome 00155, Italy
    Hum Reprod 20:1987-92. 2005
    ..The objective of this trial was to evaluate the presence and nature of ovarian tissue adjacent to the endometrioma cyst wall obtained by stripping with different techniques...
  12. ncbi Inflammatory status influences aromatase and steroid receptor expression in endometriosis
    Orhan Bukulmez
    Department of Obstetrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9032, USA
    Endocrinology 149:1190-204. 2008
    Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with endometriosis has been reported. Aromatase induction may be mediated by increased cyclooxygenase-2 (COX-2)...
  13. ncbi Migraine is associated with menorrhagia and endometriosis
    Gretchen E Tietjen
    Department of Neurology, Medical College of Ohio, Toledo 43614, USA
    Headache 46:422-8. 2006
    OBJECTIVE: To evaluate the frequency of menorrhagia and endometriosis in female migraineurs compared to age-matched women without headache...
  14. ncbi Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
    N Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 191:217-26. 2011
    b>Endometriosis is a very common disease that is characterized by increased formation of estradiol and disturbed progesterone action...
  15. ncbi Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Hum Reprod 21:262-8. 2006
    Angiogenesis represents the crucial step in the pathogenesis of endometriosis, because endometriotic lesions require neovascularization to establish, proliferate and invade inside the peritoneal cavity...
  16. ncbi Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    b>Endometriosis is a common gynecological disease associated with pelvic pain and subfertility...
  17. ncbi Anti-angiogenic treatment of endometriosis: biochemical aspects
    R N Taylor
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, USA
    Gynecol Obstet Invest 57:54-6. 2004
  18. ncbi Endometriosis
    Linda C Giudice
    Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproduction, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Lancet 364:1789-99. 2004
    b>Endometriosis is an oestrogen-dependent disorder that can result in substantial morbidity, including pelvic pain, multiple operations, and infertility...
  19. ncbi Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium
    Ruthy Shaco-Levy
    Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Beer Sheva, Israel
    Eur J Obstet Gynecol Reprod Biol 139:226-32. 2008
    b>Endometriosis and endometrial endometrioid carcinoma are both capable of invasion and metastasis, but their biological behavior is strikingly different...
  20. ncbi Haplotype analysis of the matrix metalloproteinase-9 gene associated with advanced-stage endometriosis
    You Jung Han
    Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, South Korea
    Fertil Steril 91:2324-30. 2009
    To investigate whether the -1562C>T, R279Q, P574R, and R668Q polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene are related to endometriosis.
  21. ncbi Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis
    Valentino Remorgida
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
    Aust N Z J Obstet Gynaecol 47:222-5. 2007
    It has recently been suggested that aromatase inhibitors may effectively reduce pain symptoms related to the presence of endometriosis both in postmenopausal women and in subjects of reproductive age.
  22. ncbi Aromatase inhibitors in the treatment of severe endometriosis
    Noha A Mousa
    Institute of Medical Science, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Obstet Gynecol 109:1421-3. 2007
    b>Endometriosis-associated chronic pelvic pain unresponsive to surgical menopause is a difficult clinical problem.
  23. ncbi Letrozole and norethisterone acetate in colorectal endometriosis
    Simone Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
    Eur J Obstet Gynecol Reprod Biol 150:199-202. 2010
    Up to now limited attention has been given to the medical treatment of bowel endometriosis. This study evaluates the efficacy of aromatase inhibitors and norethisterone acetate in treating pain and gastrointestinal symptoms caused by ..
  24. ncbi Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis
    S Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Largo R Benzi 1 16132, Genoa, Italy
    Hum Reprod 24:3033-41. 2009
    The available data on effectiveness of aromatase inhibitors in treating pain symptoms related to endometriosis is limited...
  25. ncbi Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study
    Radhika K Ailawadi
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA
    Fertil Steril 81:290-6. 2004
    ..To determine the role of an aromatase inhibitor, letrozole, in the treatment of reproductive-age women with endometriosis and associated chronic pelvic pain. DESIGN: Phase 2, open-label, nonrandomized proof-of-concept study...
  26. ncbi Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor
    H M Fatemi
    Centre of Reproductive Medicine, AZ VUB, University Hospital, Dutch speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    Reprod Biomed Online 11:455-7. 2005
    ..Medical management of recurrent post-menopausal endometriosis with aromatase inhibitors seems to be an effective alternative treatment to surgery.
  27. ncbi Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis
    Joanna M Day
    Department of Endocrinology and Metabolic Medicine, Imperial College, London, London W2 1NY, UK
    Endocr Relat Cancer 15:665-92. 2008
    ..of these enzymes for the treatment of steroid-dependent diseases, including breast and prostate cancer, and endometriosis, with demonstrable efficacy in in vivo disease models...
  28. ncbi Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    Richard O Burney
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Endocrinology 148:3814-26. 2007
    The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and toward developing novel strategies for the treatment of ..
  29. ncbi Health-related quality of life measurement in women with common benign gynecologic conditions: a systematic review
    Georgina L Jones
    Nuffield Department of Obstetrics and Gynaecology and the Health Services Research Unit, Division of Public Health and Primary Health Care, University of Oxford, United Kingdom
    Am J Obstet Gynecol 187:501-11. 2002
    b>Endometriosis, menorrhagia, chronic pelvic pain, and polycystic ovary syndrome are major sources of psychologic morbidity and can negatively affect quality of life...
  30. ncbi Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management
    Masaki Mandai
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Int J Clin Oncol 14:383-91. 2009
    Recent molecular and pathological evidence suggests that endometriosis is a monoclonal, neoplastic disease...
  31. ncbi The pains of endometriosis
    Karen J Berkley
    Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA
    Science 308:1587-9. 2005
    b>Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production...
  32. ncbi The relationship of endometriosis and ovarian malignancy: a review
    Farr Nezhat
    Department of Obstetrics, Mount Sinai Medical Center, New York, New York 10019, USA
    Fertil Steril 90:1559-70. 2008
    To review the malignant potential of endometriosis based on epidemiologic, histopathologic, and molecular data.
  33. ncbi Aberrant integrin expression in the endometrium of women with endometriosis
    B A Lessey
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599
    J Clin Endocrinol Metab 79:643-9. 1994
    ..To investigate the expression of this integrin in women with endometriosis, we assessed the presence of the beta 3-subunit throughout the menstrual cycle in 268 "in-phase" ..
  34. ncbi Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:3261-7. 2007
    b>Endometriosis is an estrogen-dependent disease...
  35. ncbi Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
    Eric M Grund
    EMD Serono Research Institute, One Technology Place, Rockland, MA 02190, USA
    Mol Pharmacol 73:1394-404. 2008
    ....
  36. ncbi Increased frequency of migraine among women with endometriosis
    S Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R Benzi 1, 16132 Genoa, Italy
    Hum Reprod 19:2927-32. 2004
    Our aim is to assess the prevalence and characteristics of headache in patients with endometriosis compared with women without this disease.
  37. ncbi Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease
    Marc Bazot
    Department of Radiology, Hopital Tenon, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, Paris 75020, France
    Radiology 232:379-89. 2004
    To prospectively evaluate the accuracy of magnetic resonance (MR) imaging for the preoperative diagnosis of deep pelvic endometriosis and extension of the disease.
  38. ncbi Use of the SF-36 questionnaire to predict quality-of-life improvement after laparoscopic colorectal resection for endometriosis
    G Dubernard
    Department of Obstetrics and Gynecology, Hopital Tenon, AP HP, Universite Pierre et Marie Curie Paris VI, 4 rue de Chine, 75020 Paris, France
    Hum Reprod 23:846-51. 2008
    Laparoscopic colorectal resection for endometriosis can improve quality of life (QOL), but the results vary widely from one woman to another...
  39. ncbi Impact of GnRH agonist treatment on recurrence of ovarian endometriomas after conservative laparoscopic surgery
    Byung Chul Jee
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea
    Fertil Steril 91:40-5. 2009
    ..To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment...
  40. ncbi The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity
    Kevin S Jackson
    Department of Obstetrics and Gynecology MC808, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Reprod Sci 14:137-50. 2007
    ..receptors (Pgr), and the chaperone immunophilin FKBP52 in the eutopic endometrium in a baboon model of endometriosis during the window of receptivity to determine if their aberrant distribution contributes to reduced fecundity...
  41. ncbi Proteomic approaches in endometriosis research
    Anne E Poliness
    Departments of Perinatal Medicine and Gynaecology, The Royal Women s Hospital, 132 Grattan Street, Carlton, Melbourne 3053, Australia
    Proteomics 4:1897-902. 2004
    To date, the quest to develop a noninvasive diagnostic test for endometriosis has mostly concentrated on the levels of cytokines and growth factors that are involved in inflammation, angioneogenesis and tissue remodeling, present in ..
  42. ncbi Endometriosis and infertility: epidemiology and evidence-based treatments
    Sebiha Ozkan
    Department of Obstetrics and Gynecology, Kocaeli University School of Mediine, Kocaeli, Turkey
    Ann N Y Acad Sci 1127:92-100. 2008
    b>Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0...
  43. ncbi Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane
    Annemiek W Nap
    Department of Obstetrics and Gynaecology, Research Institute Growth and Development (GROW, Maastricht University and University Hospital, Maastricht, The Netherlands
    Fertil Steril 83:793-5. 2005
    ..the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model...
  44. ncbi High-dose pilot study with the novel progestogen dienogestin patients with endometriosis
    A E Schindler
    Department of Gynecology and Obstetrics, University of Essen, Essen, Germany
    Gynecol Endocrinol 22:9-17. 2006
    High-dose dienogest (20 mg/day) was used for the treatment of endometriosis in women aged 18-52 years after laparoscopic and histological diagnosis of endometriosis and staging according to the revised American Fertility Society criteria...
  45. ncbi Apoptosis and endometriosis
    Tasuku Harada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Front Biosci 12:3140-51. 2007
    ..Eutopic endometrium from women with endometriosis reportedly has some fundamental differences compared with normal endometrium of women without endometriosis...
  46. ncbi Laparoscopic colorectal resection for bowel endometriosis: feasibility, complications, and clinical outcome
    Luca Minelli
    Department of Obstetrics and Gynecology, Ospedale Sacro Cuore, Negrar, Italy
    Arch Surg 144:234-9; discussion 239. 2009
    To evaluate the short- and long-term outcomes of laparoscopic colorectal resection for endometriosis.
  47. ncbi MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility
    Cherry Yin Yi Chang
    Human Genetic Center, China Medical University Hospital, Taichung, Taiwan
    BMC Med 9:19. 2011
    Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown.
  48. ncbi Surgical management of deep infiltrating endometriosis of the rectum: pleading for a symptom-guided approach
    Horace Roman
    Department of Gynecology and Obstetrics, Clinique Gynécologique et Obstétricale, Rouen University Hospital, 1 rue de Germont, 76031 Rouen, France
    Hum Reprod 26:274-81. 2011
    Two surgical approaches are usually employed in the treatment of deep infiltrating endometriosis of the rectum (DIER): colorectal resection removing the rectal segment affected by the disease, and nodule excision either without opening ..
  49. ncbi Endometriosis and infertility: a multi-cytokine imbalance versus ovulation, fertilization and early embryo development
    S Vassiliadis
    Department of Biology, University of Crete, Heraklion, Crete, Greece
    Clin Dev Immunol 12:125-9. 2005
    b>Endometriosis is tightly linked to infertility which is manifested at very early or more advanced stages of the gestational cycle...
  50. ncbi Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrasov trg 2, 1000 Ljubljana, Slovenia
    Gynecol Endocrinol 23:105-11. 2007
    b>Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites, and it is well known that endometriosis is an estrogen-dependent disease...
  51. ncbi Comparative proteomic analysis of human adenomyosis using two-dimensional gel electrophoresis and mass spectrometry
    Haiyuan Liu
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China
    Fertil Steril 89:1625-31. 2008
    ..To identify the differently expressed proteins in adenomyotic tissue compared with normal uterine muscle...
  52. ncbi Outcome of in vitro fertilization and ovarian response after endometrioma stripping at laparoscopy and laparotomy
    Namik Kemal Duru
    Department of Obstetrics and Gynecology, Gulhane Military Medical Academy GATA School of Medicine, Ankara, Turkey
    J Reprod Med 52:805-9. 2007
    ..To add further data on in vitro fertilization (IVF) outcome and ovarian response after endometrioma stripping via either laparoscopy or laparotomy...
  53. ncbi Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity
    Petra A B Klemmt
    Nuffield Department of Obstetrics and Gynaecology, The Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Fertil Steril 85:564-72. 2006
    ..differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis. DESIGN: Experimental study using phase contrast microscopy, immunocytochemistry, and functional bioassays...
  54. ncbi Health-related quality of life burden of women with endometriosis: a literature review
    Xin Gao
    Abt Associates Inc, Bethesda, MD 20817 5341, USA
    Curr Med Res Opin 22:1787-97. 2006
    The purpose of this study was to conduct a comprehensive and systematic literature review of the health-related quality of life (HRQL) burden of endometriosis in adults and adolescents.
  55. ncbi Villar's nodule: a case report and systematic literature review of endometriosis externa of the umbilicus
    Rahi Victory
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
    J Minim Invasive Gynecol 14:23-32. 2007
    We report a case of umbilical endometriosis externa and systematically review the literature regarding this finding...
  56. ncbi Endometrioma undergoing laparoscopic ovarian cystectomy: its influence on the outcome of in vitro fertilization and embryo transfer (IVF-ET)
    Tao-Chuan Loo
    Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Chi-Mei Medical Center, Tainan, Taiwan
    J Assist Reprod Genet 22:329-33. 2005
    ..CONCLUSIONS: Women who received ovarian cystectomy for endometriomas have fewer oocytes harvested during IVF treatment. However, their chance of pregnancy was comparable to patients with tubal problems who underwent IVF treatment...
  57. ncbi Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study
    Lukas A Hefler
    Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 84:1033-6. 2005
    ..25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometriosis. In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and ..
  58. ncbi Long-term follow-up after conservative surgery for bladder endometriosis
    Luigi Fedele
    Department of Obstetrics and Gynecology, Ospedale San Paolo, Italy
    Fertil Steril 83:1729-33. 2005
    To describe the long-term outcome of surgical conservative treatment of bladder endometriosis.
  59. ncbi Surgical outcome and long-term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis
    R Seracchioli
    Center of Reconstructive Pelvic Endo surgery, Reproductive Medicine Unit, S Orsola Hospital, University of Bologna, Bologna, Italy
    BJOG 114:889-95. 2007
    ..was to assess the long-term outcome of treating severely symptomatic women with deep infiltrating intestinal endometriosis by laparoscopic segmental rectosigmoid resection...
  60. ncbi Long-term follow-up after conservative surgery for rectovaginal endometriosis
    Luigi Fedele
    Clinica Ostetrico Ginecologica dell Università di Milano, Ospedale San Paolo, Milan, Italy
    Am J Obstet Gynecol 190:1020-4. 2004
    The purpose of this study was to evaluate long-term results in patients who received conservative surgical treatment for rectovaginal endometriosis.
  61. ncbi Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE
    Andrew N Stephens
    Prince Henry s Institute of Medical Research, Department of Obstetrics and Gynecology, Monash University, and Monash IVF, Clayton, Victoria, 3168, Australia
    J Proteome Res 9:2438-49. 2010
    b>Endometriosis is a chronic disorder affecting approximately 10% of women in whom endometrial tissue forms painful lesions outside the uterus...
  62. ncbi Robotic-assisted laparoscopic partial bladder resection for the treatment of infiltrating endometriosis
    Connie Liu
    Division of Gynecologic Minimally Invasive Surgery, Department of Obstetrics, Gynecology, and Reproductive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Minim Invasive Gynecol 15:745-8. 2008
    ..article reveals our surgical approach for treatment of a patient with severe pelvic and infiltrative bladder endometriosis with mucosal involvement using robotic-assisted laparoscopic excision and cystotomy repair...
  63. ncbi Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation
    Hsin-Yi Ho
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sec. 2, Chung Shan North Road, Taipei 10449, Taiwan
    J Assist Reprod Genet 19:507-11. 2002
    ..3 and 17.6%. CONCLUSIONS: Surgery for ovarian endometrioma may damage ovarian reserve. It potentially results in poor ovarian response to COH, compared to the response of the contralateral normal ovary in the same individual...
  64. ncbi The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease
    F B Lockhat
    Department of Obstetrics and Gynaecology, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Hum Reprod 19:179-84. 2004
    BACKGROUND: Medical treatment of endometriosis, a condition which significantly affects the quality of life in approximately 10-15% of women in the reproductive years, remains problematic...
  65. ncbi Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients
    Alka Verma
    Women s Hospital, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Eur J Obstet Gynecol Reprod Biol 143:112-5. 2009
    Not every patient with endometriosis responds to currently recommended conventional medical treatment regimens...
  66. ncbi Effects of previous ovarian surgery for endometriosis on the outcome of assisted reproduction treatment
    Selmo Geber
    ORIGEN, Centro de Medicina Reprodutiva, Av Contorno 7747, Belo Horizonte, Minas Gerais, CEP 30 010020, Brazil
    Reprod Biomed Online 5:162-6. 2002
    b>Endometriosis affects 2-50% of women at reproductive age. Surgery is an option for treatment, but there is no convincing evidence that it promotes a significant improvement in fertility...
  67. ncbi Recurrence of endometriosis and its control
    Sun Wei Guo
    Institute of Obstetric and Gynecologic Research, Shanghai Jiao Tong University School of Medicine, Renji Hospital, 145 Shandong Zhong Road, Shanghai 200001, People s Republic of China
    Hum Reprod Update 15:441-61. 2009
    BACKGROUND Although surgery is currently the treatment of choice for managing endometriosis, recurrence poses a formidable challenge...
  68. ncbi Absence of aromatase protein and mRNA expression in endometriosis
    S Colette
    Universite Catholique de Louvain, Faculty of Medicine, Gynecology Unit, 1200 Brussels, Belgium
    Hum Reprod 24:2133-41. 2009
    ..has been reported to be involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of endometriosis patients...
  69. ncbi Pharmacological treatment of endometriosis: experience with aromatase inhibitors
    Simone Ferrero
    Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Largo R Benzi 1, Genoa, Italy
    Drugs 69:943-52. 2009
    Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents...
  70. ncbi Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review)
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara 634 8522, Japan
    Oncol Rep 22:233-40. 2009
    ..Both tumor types are often associated with endometriosis. EAC is recently reported to be characterized by K-RAS activation and PTEN dysfunction...
  71. ncbi A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis
    Gunter Kohler
    Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany
    Int J Gynaecol Obstet 108:21-5. 2010
    To compare the efficacy and safety of dienogest at doses of 1, 2, and 4mg/day orally in the treatment of endometriosis.
  72. ncbi Current pharmacotherapy for endometriosis
    Simone Ferrero
    San Martino Hospital and University of Genoa, Department of Obstetrics and Gynaecology, Largo Rosanna Benzi 1, 16132, Genoa, Italy
    Expert Opin Pharmacother 11:1123-34. 2010
    Medical therapy is the most commonly used treatment for endometriosis. In particular, the administration of hormonal therapies aims to improve symptoms with minimal adverse effects.
  73. ncbi Anti muellerian hormone serum levels in women with endometriosis: a case-control study
    Omar Shebl
    Department of Obstetrics and Gynecology, IVF Unit, Landesfrauen und Kinderklinik, Linz, Austria
    Gynecol Endocrinol 25:713-6. 2009
    To compare the anti muellerian hormone (AMH) serum levels in women with and without endometriosis.
  74. ncbi Patients' report on how endometriosis affects health, work, and daily life
    Jessica Fourquet
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00731
    Fertil Steril 93:2424-8. 2010
    The objective of this study was to assess the burden of endometriosis by obtaining patient-reported outcome data describing the experience of living with this disease...
  75. ncbi Effect and safety of high-dose dienogest (20 mg/day) in the treatment of women with endometriosis
    Adolf E Schindler
    Institute for Medical Research and Education, 45122 Essen, Germany
    Arch Gynecol Obstet 282:507-14. 2010
    Hormonal treatment of endometriosis is often continued for long periods and has the potential to affect many essential metabolic processes...
  76. ncbi Long-term use of dienogest for the treatment of endometriosis
    Mikio Momoeda
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Obstet Gynaecol Res 35:1069-76. 2009
    To investigate the safety and efficacy of 52 weeks of dienogest treatment in patients with endometriosis.
  77. ncbi Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas
    Hiroaki Ishihara
    Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Fertil Steril 79:735-42. 2003
    ..GnRH agonists or danazol therapy normalizes estrogen metabolism in the eutopic endometrium of women with endometriosis, adenomyosis, or leiomyomas. DESIGN: Prospective clinical study. SETTING: University hospital...
  78. ncbi 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis
    Christian M Becker
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Womens Centre Headington, University of Oxford, Oxford, OX3 9DU, UK
    Am J Pathol 172:534-44. 2008
    b>Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years...
  79. ncbi Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis
    Christer Borgfeldt
    Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden
    Acta Obstet Gynecol Scand 83:395-400. 2004
    BACKGROUND: The aim was to evaluate whether patients with benign ovarian cysts, functional ovarian cysts, or endometriosis have an increased risk of developing gynecologic cancer...
  80. ncbi Endometriosis and tissue factor
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine 333 Cedar St, P O Box 208063, New Haven, CT, 06520 8063, USA
    Ann N Y Acad Sci 1127:101-5. 2008
    ..TF expression is altered in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium...
  81. ncbi Serum levels of VEGF and TNF-alpha and their association with C-reactive protein in patients with endometriosis
    Pedro Xavier
    Department of Gynecology and Obstetrics, Sao Joao Hospital, University of Porto Medical School, 4200 319, Porto, Portugal
    Arch Gynecol Obstet 273:227-31. 2006
    ..endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers.
  82. ncbi Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles
    E Somigliana
    Infertility Unit, Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Milan, Italy
    Hum Reprod 18:2450-3. 2003
    ..Ultrasonographic evaluation of ovarian response to ovulation stimulation represents a simple yet poorly employed tool to assess residual ovarian function after surgery...
  83. ncbi Expression of interleukin-10 in patients with adenomyosis
    Fei Wang
    Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    Fertil Steril 91:1681-5. 2009
    ..To investigate the expression of interleukin-10 (IL-10) in adenomyosis...
  84. ncbi Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs.
  85. ncbi Prognostic implication of endometriosis in clear cell carcinoma of the ovary
    J P Orezzoli
    Gillette Center for Gynecologic Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gynecol Oncol 110:336-44. 2008
    The aim of this study is to investigate whether the presence of endometriosis is a prognostic factor in patients diagnosed with clear cell carcinoma (CCC) of the ovary.
  86. ncbi Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis--a randomized, double-blind, multicenter, controlled trial
    Tasuku Harada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Fertil Steril 91:675-81. 2009
    To compare the efficacy and safety of dienogest (DNG) with intranasal buserelin acetate (BA) in patients with endometriosis.
  87. ncbi Pain, quality of life and complications following the radical resection of rectovaginal endometriosis
    Jolyon Ford
    Department of Obstetrics and Gynaecology, Worthing and Southlands Hospitals Trust, UK
    BJOG 111:353-6. 2004
    ..the long term response, quality of life and levels of pain following the radical excision of rectovaginal endometriosis. DESIGN: A cohort study. SETTING: A tertiary referral centre for the management of advanced endometriosis...
  88. ncbi [Summary of the second national conference on endometriosis]
    Lan Zhu
    Zhonghua Fu Chan Ke Za Zhi 41:652-5. 2006
  89. ncbi [Ovarian endometriomas: Effect of laparoscopic cystectomy on ovarian response in IVF-ET cycles]
    C Yazbeck
    Service de gynécologie obstétrique et médecine de la reproduction, maternité Aline de Crépy, Hopital Bichat Claude Bernard, 46, rue Henri Huchard, 75018 Paris, France
    Gynecol Obstet Fertil 34:808-12. 2006
    ..To investigate the follicular response to controlled ovarian hyperstimulation (COH) in IVF-ET cycles after laparoscopic ovarian cystectomy for large endometriomas...
  90. ncbi [Reproductive outcome in women with ovarian endometriosis--retrospective analytical study]
    E Kucera
    Ustav pro péci o matku a díte, Praha
    Ceska Gynekol 70:431-5. 2005
    To evaluate our clinical results and reproductive outcome after laparoscopic surgery for ovarian endometriosis in infertile women.
  91. ncbi Tumour necrosis factor-alpha blockers: potential limitations in the management of advanced endometriosis? A case report
    Khashayar Shakiba
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Reprod 21:2417-20. 2006
    ..have shown that tumour necrosis factor (TNF)-alpha levels are increased in the peritoneal fluid of women with endometriosis, with correlation between TNF-alpha concentrations and the degree of disease...
  92. ncbi Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis
    Lin Mu
    Department of Gynecology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Fertil Steril 89:529-37. 2008
    To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis.
  93. ncbi Endometriosis and chronic pain: a multispecialty roundtable discussion
    Barbara S Levy
    Women's Health Center, Franciscan Health System, Federal Way, Wash, USA
    J Fam Pract 56:S3-13. 2007
  94. ncbi Serum antiendometrial antibodies and diagnosis of endometriosis
    Gary W Randall
    Department of Obstetrics and Gynecology, WVU School of Medicine, Charleston Division, Charleston, WV 23502, USA
    Am J Reprod Immunol 58:374-82. 2007
    The purpose of the present prospective multi-center study is to investigate the relationship between laparoscopic diagnosis of endometriosis and results of a serum antiendometrial antibody (AEA) assay.
  95. ncbi A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma
    Saeed Alborzi
    Shiraz University of Medical Sciences, Shiraz, Iran
    Fertil Steril 88:507-9. 2007
    ....
  96. ncbi Efficacy of office diagnostic hysterofibroscopy
    Chi Chang Chang
    E Da Hospital of Kaohsiung County, Taiwan
    J Minim Invasive Gynecol 14:172-5. 2007
    ..To evaluate the feasibility and efficacy of hysterofibroscopy as an office diagnostic tool...
  97. ncbi The frequency of ovulation from the affected ovary decreases following laparoscopic cystectomy in infertile women with unilateral endometrioma during a natural cycle
    Takashi Horikawa
    Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Okura, Setagaya, Tokyo, Japan
    J Assist Reprod Genet 25:239-44. 2008
    ..To evaluate the cystectomy-induced damage on the follicular growth and ovulation of an affected ovary during natural cycles...
  98. ncbi Stem cells and the pathogenesis of endometriosis
    Isaac E Sasson
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1127:106-15. 2008
    b>Endometriosis is a common gynecological disorder that is defined by the presence of endometrial tissue outside the uterine cavity. This disease often results in extensive morbidity, including chronic pelvic pain and infertility...
  99. ncbi Impact of laparoscopic cystectomy on fecundity of infertility patients with ovarian endometrioma
    Koji Nakagawa
    Division of Reproductive Medicine, Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan
    J Obstet Gynaecol Res 33:671-6. 2007
    ..To clarify the effect of laparoscopic cystectomy for ovarian endometrioma in infertility patients, the pregnancy outcome was evaluated...
  100. ncbi Minimally invasive exploration of the female reproductive tract in infertility
    Rudi Campo
    Leuven Institute for Fertility and Embryology, Tiensevest 168, 3000 Leuven, Belgium
    Reprod Biomed Online 4:40-5. 2002
    ..In addition, in patients with mild endometriosis, more peri-ovarian adhesions were detected with THL than with standard laparoscopy...
  101. ncbi Ovarian endometrioma vascularization in women with pelvic pain
    Juan Luis Alcazar
    Department of Obstetrics and Gynecology, Clinica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain
    Fertil Steril 87:1271-6. 2007
    ..To assess whether a correlation exists between angiogenesis in ovarian endometrioma with the presence of pelvic pain...

Research Grants93

  1. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
    ..Women with the primary diagnosis of endometriosis had fewer eggs retrieved, whereas diagnosis of hernia or varicocele was linked to decreased sperm ..
  2. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
    b>Endometriosis affects 5-10% of reproductive-age women with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility...
  3. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  4. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  5. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  6. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen Berkley; Fiscal Year: 2009
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  7. NEURAL MECHANISMS OF GYNECOLOGICAL PAIN
    Karen J Berkley; Fiscal Year: 2010
    ..Current studies focus on endometriosis, a disorder defined by extrauteral growths of endometrial tissue...
  8. Cooperative Multicenter Reproductive Medicine Network (U10)
    Gregory Christman; Fiscal Year: 2007
    ..experience in areas of interest to the Network including infertility, andrology, abnormal uterine bleeding, endometriosis, leiomyomata uteri, polycystic ovarian syndrome, and assisted reproductive technology...
  9. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
    b>Endometriosis, the third leading cause of gynecologic hospitalization in the United States, remains one of the most enigmatic gynecologic pathologies...
  10. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..Epithelial cells trapped in inclusion cysts or deriving from endometriosis may be more susceptible to local or circulating growth factors...
  11. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    b>Endometriosis is a common gynecologic disease affecting up to 10% of reproductive-age women. Despite this high prevalence and the severe symptoms associated with the disease, little is known about the pathogenesis of endometriosis...
  12. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..Yeaman an assistant professor at Dartmouth Medical School (DMS) studies the role of carbohydrate antigens in endometriosis and HIV infection will be combined with that of Drs. William Wade and Bruce Reinhold. Dr...
  13. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    b>Endometriosis is a common gynecologic disease affecting up to 10% of reproductive-age women. Despite this high prevalence and the severe symptoms associated with the disease, little is known about the pathogenesis of endometriosis...
  14. SNP Analysis of Endometriosis Candidate Genes
    Idhaliz Flores; Fiscal Year: 2006
    b>Endometriosis is a poorly understood gynecologic condition defined as the presence of endometrial tissue in the peritoneum, ovaries, and other organs...
  15. FEMALE REPRODUCTIVE OUTCOMES AND TCDD EXPOSURE
    Brenda Eskenazi; Fiscal Year: 2001
    ..of the SWHS was to investigate the relationship of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) and endometriosis in a nested case-control study embedded in a cohort of women exposed to extremely high levels of dioxin as a ..
  16. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 2002
    ..more regular, and shorter cycles--a pattern indicative of greater opportunity for retrograde menstruation and endometriosis, a possible precursor of E/CC cancers...
  17. GONADOTROPIN-RELEASING HORMONE ACTION
    P Conn; Fiscal Year: 2007
    ..Among these are treatments for endometriosis/fibroids, polycystic ovary disease, perimenopause, protection of the ovary and testes (i.e...
  18. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    Approximately one-third of women with chronic pelvic pain have endometriosis. Surgical treatment of endometriosis with laparoscopic excision of implants and lysis of adhesions is often successful in reducing pain in the short term...
  19. Biochemical and pharmacological studies of human membrane progesterone receptors
    Thomas J Lyons; Fiscal Year: 2010
    ..pharmaceutical importance, being most commonly used for birth control and in the treatment of cancer and endometriosis. Traditionally, the biological activity of such molecules has been tested by investigating their effects on ..
  20. Biochemical and pharmacological studies of human membrane progesterone receptors
    Thomas J Lyons; Fiscal Year: 2010
    ..pharmaceutical importance, being most commonly used for birth control and in the treatment of cancer and endometriosis. Traditionally, the biological activity of such molecules has been tested by investigating their effects on ..
  21. ENDOMETRIOSIS :TRADITIONAL MEDICINE VS HORMONE THERAPY
    Richard Hammerschlag; Fiscal Year: 2002
    DESCRIPTION (APPLICANT'S ABSTRACT): Endometriosis is a significant public health problem affecting 10-15% of women of childbearing age, many of whom suffer persistent pelvic pain and infertility...
  22. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2001
    b>Endometriosis affects up to 10% of women of reproductive age in the U.S. with chronic pelvic pain, dysmenorrhea, and probable increased risk of infertility...
  23. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..overall goal of this project is to understand the mechanism of action and clinical potential of retinoids in endometriosis. We propose that retinoids play both a causative role in the development of endometriosis and have therapeutic ..
  24. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..overall goal of this project is to understand the mechanism of action and clinical potential of retinoids in endometriosis. We propose that retinoids play both a causative role in the development of endometriosis and have therapeutic ..