choroidal neovascularization

Summary

Summary: A pathological process consisting of the formation of new blood vessels in the CHOROID.

Top Publications

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
  2. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
  3. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
  4. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
  5. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
  6. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
  7. ncbi Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials
    P Mitchell
    Eye Clinic B4A, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145, Australia
    Br J Ophthalmol 94:2-13. 2010
  8. ncbi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
  9. ncbi A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study
    Geeta A Lalwani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 148:43-58.e1. 2009
  10. ncbi Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization
    Hans E Grossniklaus
    Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Mol Vis 8:119-26. 2002

Detail Information

Publications317 found, 100 shown here

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
    ..Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration...
  2. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
    ....
  3. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    ..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
  4. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
    ..Moreover, miR-23 and miR-27 are required for pathological angiogenesis in a laser-induced choroidal neovascularization mouse model...
  5. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
    There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models...
  6. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
    ..In humans with AMD, MCs accumulated in the subretinal space at sites of retinal degeneration and choroidal neovascularization (CNV)...
  7. ncbi Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials
    P Mitchell
    Eye Clinic B4A, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145, Australia
    Br J Ophthalmol 94:2-13. 2010
    ..Ranibizumab is approved for treating neovascular AMD. However, further guidance is needed to assist ophthalmologists in clinical practice to optimise treatment outcomes...
  8. ncbi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
    To evaluate the efficacy and safety of ranibizumab administered monthly for three months and then quarterly in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  9. ncbi A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study
    Geeta A Lalwani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 148:43-58.e1. 2009
    ....
  10. ncbi Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization
    Hans E Grossniklaus
    Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Mol Vis 8:119-26. 2002
    To determine the expression of angiogenic cytokines in macrophages and retinal pigment epithelium cells in choroidal neovascularization (CNV).
  11. ncbi Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    Napoleone Ferrara
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Retina 26:859-70. 2006
    ..Among these, ranibizumab is a high affinity recombinant Fab that neutralizes all isoforms of VEGF-A. The article briefly reviews the biology of VEGF and then focuses on the path that led to clinical development of ranibizumab...
  12. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004
    ..Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration...
  13. pmc Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344
    Ping Xie
    Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 6:e28933. 2011
    To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal neovascularization (CNV).
  14. pmc Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration
    Tatyana I Metelitsina
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 49:358-63. 2008
    To investigate in a longitudinal study whether foveolar choroidal blood flow changes are associated with the development of choroidal neovascularization (CNV) in AMD.
  15. ncbi In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography
    Andrea Giani
    Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3880-7. 2011
    To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT).
  16. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
    ..to develop drusen and phenotypic features similar to AMD, including an increased susceptibility to choroidal neovascularization (CNV)...
  17. ncbi Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, Texas 77030, USA
    Ophthalmology 116:57-65.e5. 2009
    ..Anti-vascular endothelial growth factor (VEGF) Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization (CNV) in Age-related Macular Degeneration (ANCHOR) compared ranibizumab with verteporfin photodynamic ..
  18. pmc Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization
    Heng Miao
    Department of Ophthalmology, People s Hospital, Peking University, Beijing, China
    Mol Vis 18:574-80. 2012
    ..of interleukin 1β, 6, 8, 10, 12p (IL-1β, IL-6, IL-8, IL-10, IL-12p), and tumor necrosis factor α (TNF-α) and the parameters of macular edema acquired by optical coherence tomography (OCT) in patients with choroidal neovascularization.
  19. pmc Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization
    Juan Liu
    Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, Arizona 72205, USA
    J Biol Chem 286:20991-1001. 2011
    ..complement membrane attack complex (MAC), CCL2, and VEGF that occur in vivo during the development of choroidal neovascularization (CNV)...
  20. ncbi HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration
    Michael A Singer
    Medical Center Ophthalmology Associates, San Antonio, Texas 78240, USA
    Ophthalmology 119:1175-83. 2012
    ..South San Francisco, CA) administered at the investigator's discretion in patients with choroidal neovascularization secondary to age-related macular degeneration.
  21. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ..with verteporfin (VISUDYNE) photodynamic therapy (PDT) in patients with predominantly classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) were retrospectively analyzed to identify ..
  22. pmc Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization
    Juan Amaral
    Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0608, USA
    Invest Ophthalmol Vis Sci 51:1318-26. 2010
    ..Here, they examined the effects of PEDF polypeptide fragments on vessel sprouting and on choroidal neovascularization (CNV) after subconjunctival administration.
  23. ncbi The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 115:116-26. 2008
    ..To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD)...
  24. ncbi Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population
    Norimoto Gotoh
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Clin Experiment Ophthalmol 36:437-42. 2008
    ....
  25. ncbi Clinical characteristics of exudative age-related macular degeneration in Japanese patients
    Ichiro Maruko
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Ophthalmol 144:15-22. 2007
    ..To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients...
  26. pmc CCR3 is a target for age-related macular degeneration diagnosis and therapy
    Atsunobu Takeda
    Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 460:225-30. 2009
    ..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition...
  27. ncbi Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration
    Susan B Bressler
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ophthalmology 116:S1-7. 2009
    ..Basic and clinical research implicates VEGF in the pathogenesis of choroidal neovascularization (CNV), although other candidate factors involved with regulation of angiogenesis exist...
  28. pmc Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration
    Sophie Lavalette
    INSERM, UMR S 872, Centre de Recherche des Cordeliers, Paris, France
    Am J Pathol 178:2416-23. 2011
    ..we have studied the expression of IL-1β in vivo and the effect of the IL-1 receptor antagonist on choroidal neovascularization (CNV) and retinal degeneration (RD)...
  29. pmc Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration
    Sandra Liakopoulos
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 49:5048-54. 2008
    ..To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD)...
  30. ncbi Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization
    Monika Jasielska
    Department of Ophthalmology, Heinrich Heine University, Dusseldorf, Germany
    Invest Ophthalmol Vis Sci 51:3874-83. 2010
    Tumor necrosis factor alpha (TNF)-alpha contributes to inflammation-associated angiogenesis. This study investigates the role of TNF-alpha receptors 1a and 1b in the development of choroidal neovascularization (CNV).
  31. pmc Improved assessment of laser-induced choroidal neovascularization
    Hassanain S Toma
    Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Microvasc Res 80:295-302. 2010
    The primary objective of this study was to develop and evaluate new methods of analyzing laser-induced choroidal neovascularization (CNV), in order to make recommendations for improving the reporting of experimental CNV in the literature...
  32. ncbi Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA
    Liping Gu
    Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
    Exp Eye Res 91:433-9. 2010
    b>Choroidal neovascularization (CNV) is one of the severe pathological consequences of the end-stage of age-related macular degeneration (AMD)...
  33. ncbi Molecular biology of choroidal neovascularization
    Ming Lu
    Vantage Eye Center, 622 Abbott Street, Salinas, CA 93901, USA
    Ophthalmol Clin North Am 19:323-34. 2006
    ..Safe and effective drug-delivery systems are also required for the successful anti-VEGF therapies for AMD and other ocular diseases with CNV...
  34. pmc Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions
    Xiao Dong
    Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    PLoS ONE 6:e18481. 2011
    b>Choroidal neovascularization (CNV) is the common pathological basis of irreversible visual impairment encountered in a variety of chorioretinal diseases; the pathogenesis of its development is complicated and still imperfectly understood...
  35. pmc Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
    Kanako Izumi-Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:2149-58. 2007
    Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with age-related macular degeneration; however, the ..
  36. pmc The association of age-related maculopathy susceptibility 2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Vis 17:977-82. 2011
    ....
  37. ncbi Perspectives of choroidal neovascularization therapy
    M Caputo
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Italy
    Curr Drug Targets 12:234-42. 2011
    Vision loss secondary to Choroidal Neovascularization (CNV) is becoming a major disease condition in developed world...
  38. ncbi Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization
    Michael J Tolentino
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Retina 24:132-8. 2004
    To determine the safety and efficacy of small interfering RNA (siRNA) directed against vascular endothelial growth factor (VEGF) in a nonhuman primate model of laser-induced choroidal neovascularization (CNV).
  39. ncbi Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    Magdalena G Krzystolik
    Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 120:338-46. 2002
    ..efficacy of intravitreal injections of an antigen-binding fragment of a recombinant humanized monoclonal antibody directed toward vascular endothelial growth factor (rhuFab VEGF) in a monkey model of choroidal neovascularization (CNV).
  40. pmc Drusen complement components C3a and C5a promote choroidal neovascularization
    Miho Nozaki
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 103:2328-33. 2006
    ..Although drusen nearly always precede and increase the risk of choroidal neovascularization (CNV), the late vision-threatening stage of AMD, it is unknown whether drusen contribute to the ..
  41. ncbi Subtype lesions of neovascular age-related macular degeneration in Chinese patients
    Yan Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou 510060, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 245:1441-5. 2007
    ..To identify the subtype frequency and clinical features of neovascular age-related macular degeneration (AMD) in Chinese patients...
  42. ncbi Clinicopathologic findings in polypoidal choroidal vasculopathy
    Hiroyuki Nakashizuka
    Department of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:4729-37. 2008
    ..To elucidate the pathogenic mechanism of polypoidal choroidal vasculopathy (PCV) based on histopathologic findings...
  43. ncbi Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration
    Hilary L Wilson
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    Am J Ophthalmol 137:615-24. 2004
    To investigate the relationship between statin and aspirin use and the risk of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD).
  44. ncbi The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization
    Chikako Tsutsumi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Leukoc Biol 74:25-32. 2003
    b>Choroidal neovascularization (CNV) is directly related to visual loss in some eye diseases, such as age-related macular degeneration...
  45. ncbi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
    ..To compare choroidal thickness between eyes with polypoidal choroidal vasculopathy (PCV) and eyes with age-related macular degeneration (AMD)...
  46. ncbi Current concepts in the pathogenesis of age-related macular degeneration
    Marco A Zarbin
    Institute of Ophthalmology and Visual Science at the New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 90 Bergen Street, Suite 6100, Newark, NJ 07103 2499, USA
    Arch Ophthalmol 122:598-614. 2004
    ..To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD)...
  47. ncbi Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization
    Alejandro Caicedo
    Bascom Palmer Eye Institute, University of Miami School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA
    Exp Eye Res 81:38-47. 2005
    ..on the role of macrophages in regulating the growth of pathological new vessels over the retina, called choroidal neovascularization (CNV)...
  48. ncbi Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium
    Takeshi Fujimoto
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 51:4694-702. 2010
    b>Choroidal neovascularization (CNV) is directly related to visual loss in persons with age-related macular degeneration (AMD) and other macular disorders...
  49. pmc A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap
    Jingtai Cao
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA
    Invest Ophthalmol Vis Sci 51:6009-17. 2010
    The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV)...
  50. pmc A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions
    Hui Yuan Hou
    Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Mol Ther 18:1837-45. 2010
    b>Choroidal neovascularization (CNV) is a common cause of severe and irreversible visual loss; however, the treatment of CNV has been hindered by its complex and poorly understood pathogenesis...
  51. ncbi Choroidal neovascularization in pathological myopia
    Kumari Neelam
    Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore
    Prog Retin Eye Res 31:495-525. 2012
    Myopic choroidal neovascularization (CNV) is one of the leading causes of visual impairment worldwide...
  52. ncbi Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University, Heidelberg, Germany
    Arch Ophthalmol 128:1281-6. 2010
    ....
  53. pmc Role of ocular complement factor H in a murine model of choroidal neovascularization
    Valeriy V Lyzogubov
    Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Pathol 177:1870-80. 2010
    ..of this study was to explore the relationship between local (ie, ocular) complement factor H (CFH) and choroidal neovascularization (CNV) associated with wet age-related macular degeneration (AMD), a leading cause of irreversible ..
  54. pmc Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study
    Abbas Shirinifard
    The Biocomplexity Institute and Department of Physics, Indiana University Bloomington, Bloomington, Indiana, United States of America
    PLoS Comput Biol 8:e1002440. 2012
    b>Choroidal neovascularization (CNV) of the macular area of the retina is the major cause of severe vision loss in adults...
  55. ncbi Refractory neovascular age-related macular degeneration secondary to polypoidal choroidal vasculopathy
    Minhee Cho
    New York University School of Medicine Manhattan Eye, Ear and Throat Hospital, Department of Ophthalmology, New York, New York, USA
    Am J Ophthalmol 148:70-8.e1. 2009
    ..To describe a neovascular pattern associated with treatment-refractory neovascular age-related macular degeneration (AMD)...
  56. ncbi A novel imaging technique for experimental choroidal neovascularization
    Mercedes Campos
    Biological Imaging Core, National Eye Institute, NIH, Bethesda, Maryland 20892 0703, USA
    Invest Ophthalmol Vis Sci 47:5163-70. 2006
    b>Choroidal neovascularization (CNV) is the end point of several ocular diseases that lead to blindness...
  57. ncbi Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population
    Xiaoqi Liu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Retina 30:1177-84. 2010
    ..Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population...
  58. ncbi Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments
    David B Rein
    Research Triangle Institute International, Research Triangle Park, North Carolina, USA
    Arch Ophthalmol 127:533-40. 2009
    ..To forecast age-related macular degeneration (AMD) and its consequences in the United States through the year 2050 with different treatment scenarios...
  59. pmc A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration
    Barbel Rohrer
    Department of Neurosciences, Division of Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 50:3056-64. 2009
    ..a novel recombinant form of fH, CR2-fH, which is targeted to sites of complement activation, in mouse choroidal neovascularization (CNV)...
  60. ncbi Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part B claims file
    Ross J Brechner
    Centers for Medicare and Medicaid Services, Woodlawn, MD 21244, USA
    Am J Ophthalmol 151:887-895.e1. 2011
    ..To describe the usage patterns of pharmacological treatments for neovascular age-related macular degeneration (AMD) in Medicare fee-for-service beneficiaries...
  61. ncbi Ocular risk factors for choroidal neovascularization in pathologic myopia
    Yasushi Ikuno
    Departments of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:3721-5. 2010
    PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS...
  62. ncbi Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
    ..The purpose of the present study was to investigate the effect of AST on the development of experimental choroidal neovascularization (CNV) with underlying cellular and molecular mechanisms.
  63. ncbi Choroidal changes associated with reticular pseudodrusen
    Giuseppe Querques
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil, Creteil, France
    Invest Ophthalmol Vis Sci 53:1258-63. 2012
    ..To analyze choroidal changes associated with reticular pseudodrusen by indocyanine green angiography (ICGA) and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT)...
  64. ncbi Agreement of time-domain and spectral-domain optical coherence tomography with fluorescein leakage from choroidal neovascularization
    Rahul N Khurana
    Retina Division, Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, Maryland 21287, USA
    Ophthalmology 117:1376-80. 2010
    To compare fluorescein leakage from choroidal neovascularization (CNV) with signs of intraretinal or subretinal fluid on time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT) in ..
  65. ncbi Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization
    Agnes Boltz
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 51:4220-5. 2010
    ..such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV)...
  66. pmc Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis
    Haoyu Chen
    Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou, China
    Mol Vis 18:816-29. 2012
    ..To investigate the genetic associations of polypoidal choroidal vasculopathy (PCV), the genetic difference between PCV and age-related macular degeneration (AMD), and the genotype-phenotype correlation of PCV...
  67. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ..of polypoidal choroidal vasculopathy (PCV) in Japanese patients presumed to have age-related macular degeneration (AMD) and compare 1-year outcomes after photodynamic therapy between PCV and choroidal neovascularization secondary to AMD.
  68. ncbi Retinal angiomatous proliferation in age-related macular degeneration
    L A Yannuzzi
    LuEsther T Mertz Retinal Research Center of Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Retina 21:416-34. 2001
    It is known that choroidal neovascularization (CNV) in age-related macular degeneration (ARMD) may erode through the retinal pigment epithelium, infiltrate the neurosensory retina, and communicate with the retinal circulation in what has ..
  69. ncbi Suppression of laser-induced choroidal neovascularization by a CCR3 antagonist
    Takeshi Mizutani
    Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Invest Ophthalmol Vis Sci 54:1564-72. 2013
    To evaluate the efficacy of a novel CCR3 antagonist for laser injury-induced choroidal neovascularization (CNV) in mice.
  70. ncbi Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series
    Wai Man Chan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, People s Republic of China
    Ophthalmology 111:1576-84. 2004
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin as a treatment for symptomatic polypoidal choroidal vasculopathy (PCV)...
  71. ncbi Associations of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genotypes with subtypes of polypoidal choroidal vasculopathy
    Koji Tanaka
    Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:7441-4. 2011
    ..complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genotypes are associated with subtypes of polypoidal choroidal vasculopathy (PCV), such as polypoidal choroidal neovascularization (CNV) and typical PCV.
  72. ncbi Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab
    Marion Funk
    Department of Ophthalmology, Medical University of Vienna, Austria
    Ophthalmology 116:2393-9. 2009
    ....
  73. ncbi The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration
    P A Campochiaro
    The Departments of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Mol Vis 5:34. 1999
    Laser photocoagulation and several experimental treatments for choroidal neovascularization (CNV) in patients with age-related macular degeneration attempt to ablate the neovascularization, but do not address underlying angiogenic stimuli...
  74. ncbi Regression of neovascular age-related macular degeneration following infliximab therapy
    Nikos N Markomichelakis
    Ocular Inflammation and Immunology Service, Gennimatas Hospital, Athens University Medical School, Athens, Greece
    Am J Ophthalmol 139:537-40. 2005
    ..To describe the effects of the antitumor necrosis factor (TNF) monoclonal antibody Infliximab systemic therapy on choroidal neovacularisation (CNV) secondary to age-related macular degeneration (AMD)...
  75. ncbi Intravitreal bevacizumab for subfoveal choroidal neovascularization in age-related macular degeneration at twenty-four months: the Pan-American Collaborative Retina Study
    J Fernando Arevalo
    Retina and Vitreous Service, Clinica Oftalmologica Centro Caracas, Caracas, Venezuela
    Ophthalmology 117:1974-81, 1981.e1. 2010
    ..San Francisco, CA) (1.25 or 2.5 mg) in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  76. ncbi EXTEND-I: safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration
    Yasuo Tano
    Department of Ophthalmology, Osaka University Medical School, Japan
    Acta Ophthalmol 88:309-16. 2010
    To evaluate the efficacy and safety of intravitreal ranibizumab for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients.
  77. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010
    ..It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD...
  78. pmc Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study
    A Okubo
    Department of Ophthalmology, Kagoshima University Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Br J Ophthalmol 86:1093-8. 2002
    ..To describe the clinical and histopathological findings in a patient with polypoidal choroidal vasculopathy...
  79. pmc Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse
    Kristopher G Sheets
    Department of Ophthalmology and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Vis 16:320-9. 2010
    ..the effects of neuroprotectin D1 (NPD1), a stereospecific derivative of docosahexaenoic acid, on choroidal neovascularization (CNV) in a laser-induced mouse model...
  80. ncbi Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Jpn J Ophthalmol 54:609-14. 2010
    ..2 kb, were genotyped. Associations were tested using single-SNP and haplotype analyses...
  81. ncbi Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization
    Julie Lecomte
    Laboratory of Tumor and Developmental Biology, Tour de Pathologie, CHU B23, Groupe Interdisciplinaire de Génoprotéomique Appliquée Research GIGA Cancer, University of Liege, 4000, Liege, Belgium
    Cell Mol Life Sci 68:677-86. 2011
    ..The contribution of MMP13 in choroidal neovascularization (CNV) formation was explored by using a murine model of laser-induced CNV and applying it to wild-type ..
  82. pmc Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice
    Alex Jones
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 108:14578-83. 2011
    ..Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV)...
  83. ncbi Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model
    Philipp S Müther
    Department of Ophthalmology, University of Dusseldorf, Dusseldorf, Germany
    Invest Ophthalmol Vis Sci 51:4831-9. 2010
    ..Microglia cells have been associated with immunologic defense and repair. The course of retinal disease after lethal irradiation for bone marrow depletion and substitution was evaluated with respect to macrophage and microglial involvement...
  84. ncbi Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy
    Kenji Yamashiro
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:8780-4. 2011
    ..To see if there is an association in Japanese between elastin gene (ELN) polymorphisms and neovascular age-related macular degeneration (AMD) or its subtypes, typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  85. ncbi Metabolic physiology in age related macular degeneration
    Einar Stefansson
    University of Iceland, National University Hospital, 101 Reykjavik, Iceland
    Prog Retin Eye Res 30:72-80. 2011
    ..If the resulting hypoxia and consequent VEGF accumulation crosses a threshold, this will trigger effusion and neovascularization...
  86. ncbi A rare case of choroidal neovascularization following macular hole surgery
    S Natarajan
    Aditya Jyot Eye Hospital Pvt Ltd, Plot no 153, Road No 9, Major Parmeshwaran Road, Opp SIWS College Gate No 3, Mumbai, Wadala, 31, India
    Graefes Arch Clin Exp Ophthalmol 244:271-3. 2006
    b>Choroidal neovascularization occurs in a wide spectrum of conditions, including degenerative, inflammatory, traumatic and hereditary conditions, all of which are characterized by breaks in Bruch's membrane...
  87. ncbi Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization
    David N Zacks
    Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2384-91. 2002
    To develop a model of verteporfin photodynamic therapy (PDT) for experimental choroidal neovascularization CNV in the rat.
  88. ncbi Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration
    Bradley T Smith
    Barnes Retina Institute, St Louis, Missouri, USA
    Retina 28:675-81. 2008
    To report the outcome for eyes treated with intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy (PDT) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD).
  89. ncbi Effect of bevacizumab on inflammation and proliferation in human choroidal neovascularization
    Olcay Tatar
    University Eye Hospital, Centre for Ophthalmology, Eberhard Karls University, Tubingen
    Arch Ophthalmol 126:782-90. 2008
    To evaluate the effect of bevacizumab (Avastin; Genentech, Inc, South San Francisco, California) on inflammation and proliferation in human choroidal neovascularization (CNV) secondary to age-related macular degeneration.
  90. ncbi Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF
    K Ohno-Matsui
    Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 189:323-33. 2001
    ..This equilibrium shift may be significant in promoting a pathological condition of RPE cells and contributing to choroidal neovascularization in age-related macular degeneration.
  91. ncbi Combination photodynamic therapy and intravitreal ranibizumab in neovascular AMD in a north Indian population: a pilot study
    Atul Kumar
    India Institute of Medical Sciences, New Delhi, India
    Retina 28:1132-7. 2008
    ..To evaluate photodynamic therapy (PDT) with verteporfin along with intravitreal Ranibizumab in treatment of neovascular age related macular degeneration...
  92. pmc Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization
    Tailoi Chan-Ling
    Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Sydney, Australia
    Am J Pathol 168:1031-44. 2006
    ..We have shown that adult HSCs differentiate into endothelial cells and participate in both retinal and choroidal neovascularization. We asked whether HSCs participated in the wounding response by forming astrocytes, retinal pigment ..
  93. ncbi Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration
    Domniki N Papadopoulou
    Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
    Ophthalmology 116:1755-61. 2009
    ..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
  94. pmc Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone
    P P Yip
    Department of Ophthalmology, Tuen Mun Hosptial, Tsing Chung Koon Road, Tuen Mun, Hong Kong
    Br J Ophthalmol 93:754-8. 2009
    ..FA was repeated at 3 and 6 months. Outcome measures included visual improvement measured by logMAR equivalent, angiographic evident of leakage and safety profile...
  95. ncbi Vision-related function after ranibizumab treatment by better- or worse-seeing eye: clinical trial results from MARINA and ANCHOR
    Neil M Bressler
    Retina Division, Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0005, USA
    Ophthalmology 117:747-56.e4. 2010
    ....
  96. ncbi Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration: a report by the American Academy of Ophthalmology
    Michael S Ip
    American Academy of Ophthalmology, Box 7424, San Francisco, CA 94120, USA
    Ophthalmology 115:1837-46. 2008
    ..To examine the evidence about the safety and efficacy of anti-vascular endothelial growth factor (VEGF) pharmacotherapies for the treatment of neovascular age-related macular degeneration (AMD)...
  97. ncbi Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107, USA
    Arch Ophthalmol 123:1658-66. 2005
    To evaluate choroidal osteoma for tumor growth, tumor decalcification, related choroidal neovascularization, visual acuity loss, and poor visual acuity.
  98. pmc Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
    S R Singh
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    Gene Ther 16:645-59. 2009
    b>Choroidal neovascularization (CNV) leads to loss of vision in age-related macular degeneration (AMD), the leading cause of blindness in adult population over 50 years old...
  99. ncbi Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation
    J L Colquitt
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 12:iii-iv, ix-201. 2008
    ..To assess the clinical effectiveness and cost-effectiveness of ranibizumab and pegaptanib for subfoveal choroidal neovascularisation (CNV) associated with wet age-related macular degeneration (AMD)...
  100. ncbi Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy
    F Gomi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:70-3. 2008
    ..The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV)...
  101. ncbi Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment--TAP and VIP report No. 2
    Irene Barbazetto
    Medizinische Universitat zu Lubeck, Klinik fur Augenheilkunde, Lubeck, Germany
    Arch Ophthalmol 121:1253-68. 2003
    ..fluorescein angiographic guidelines for the use of verteporfin therapy in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) or other conditions based on 2-year vision ..

Research Grants66

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Some studies suggest that if the development of new blood vessels (choroidal neovascularization, or CNV) is detected early, treatment could be started sooner, which may help prevent visual loss...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Some studies suggest that if the development of new blood vessels (choroidal neovascularization, or CNV) is detected early, treatment could be started sooner, which may help prevent visual loss...
  3. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..an RNAi approach for testing HIRA function in pathological angiogenesis by using a laser-induced choroidal neovascularization model and also analyzing tumor angiogenesis in a orthotopic xenograft model of breast cancer...
  4. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..The overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels into the retina...
  5. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..cascade that leads to the pathologic hallmarks of the disease, localized atrophy of the retina and choroidal neovascularization. One source of the RPE- damaging reactive oxygen species (ROS) are the mitochondria of the RPE cells ..
  6. Endothelial Cell Dysregulation in Neovascular AMD
    Mark E Kleinman; Fiscal Year: 2013
    ..The overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels beneath the retina...
  7. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..Laser-induced choroidal neovascularization in mutant eyes is significantly enhanced compared to control eyes...
  8. Complement Factor H Haplotypes and Smoking in Age-Related Macular Degeneration
    Baerbel Rohrer; Fiscal Year: 2011
    ..Current available treatments focus on the late stage of the disease (choroidal neovascularization;CNV);however, those come with significant risks and only target subpopulations of AMD patients...
  9. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
    ..The sub-retinal space then becomes a favorable environment for the development of choroidal neovascularization (CNV)...
  10. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..g. diabetic retinopathy, retinal vein occlusions, and choroidal neovascularization associated with age-related macular degeneration (AMD))...
  11. Endothelial Transmigration in Neovascular Age-related Macular Degeneration
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..Events that occur prior to the development of choroidal neovascularization (CNV) in AMD include the activation of CECs to migrate toward a chemotactic gradient in the sensory ..
  12. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2012
    ..Loss of HTRA1 function will be determined by measuring the reduction of or inability for choroidal neovascularization (CNV) to take place in homozygous and heterozygous conditional KO mice...
  13. Role of RPE-derived VEGF in Choroid Development and Stability
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ..of VEGF regulation in RPE under normal conditions may provide an opportunity to develop novel anti-VEGF therapies to inhibit the VEGF that mediates pathologic choroidal neovascularization, while sparing physiological VEGF expression.
  14. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    ..complex and/or SUMOylation will reduce vascular permeability and inhibit aberrant retinal and choroidal neovascularization. We will test this hypothesis through the following aims...
  15. RPE MESSENGERS, TRANSCRIPTION AND PHOTORECEPTOR RENEWAL
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2013
    ..relevant to dry forms of age-related macular degeneration (AMD), retinitis pigmentosa (RP) and choroidal neovascularization (CNV), as in the wet form of AMD...
  16. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  17. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
    ..two mouse models of ocular angiogenesis: the corneal neovascularization model, and a laser-induced choroidal neovascularization model...
  18. Hephaestin's role in retinal iron homeostasis and retinal health
    Natalie Wolkow; Fiscal Year: 2012
    ..of iron in RPE and photoreceptor cells, RPE hypertrophy, RPE and photoreceptor degeneration, choroidal neovascularization and immune cell infiltration, information from them is limited because they are not fertile and die ..
  19. Building a Better AMD Mouse
    Caroline J Zeiss; Fiscal Year: 2010
    ..This aim will test the hypothesis that HTRA1 overexpression can induce choroidal neovascularization typical of wet AMD...
  20. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..b>Choroidal neovascularization (CNV), the pathologic creation of new blood vessels in the choroid layer of the eye, is a principal ..
  21. MT1-MMP-based Animal Model of Age-related Macular Degeneration (AMD)
    George Inana; Fiscal Year: 2010
    ..There are two forms of AMD, the dry and the wet form, the latter being associated with choroidal neovascularization (CNV) and responsible for 90% of the blindness. AMD is a complex disease involving multiple genes...
  22. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
    ..inhibit pathologic angiogenesis in murine models of hyperoxic induced retinal vascular disease and choroidal neovascularization. These studies provide the first proof of concept that blocking HTRA1 is an effective therapeutic ..
  23. Bcl-2 and ocular neovascularization
    Christine M Sorenson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinal neovascularization and choroidal neovascularization (CNV), as occur in retinopathy of prematurity (ROP) and age-related macular degeneration (AMD), are major causes of blindness...
  24. Regulation of vascular leakage in age related macular degeneration
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2013
    ..However, the Wet form of AMD, which is characterized by choroidal neovascularization (CNV), is associated with more severe vision loss caused primarily by the leakage of fluid and blood ..
  25. Identification of Common Polymorphisms Affecting Angiogenesis
    ROBERT J D'AMATO; Fiscal Year: 2013
    ..Then we used a laser-induced model of choroidal neovascularization to demonstrate that not only was corneal angiogenic responsiveness correlated with choroidal ..
  26. Mechanisms of age-related RPE dysfunction and CNV
    Jiyang Cai; Fiscal Year: 2013
    ..drusen, and will further progress to chronic inflammation in the sub-RPE space, geographic atrophy and choroidal neovascularization (CNV)...
  27. The role of the wnt signaling pathway in choroidal neovascularization
    Jian Xing Ma; Fiscal Year: 2013
    ..The proposed studies will reveal the interactions between PPAR[unreadable] and the canonical Wnt pathway and contribute to the development of new treatment for AMD. ..
  28. Novel Method for the Ocular Iontophoretic Delivery of Avastin and Lucentis
    William I Higuchi; Fiscal Year: 2010
    ..3) To establish transscleral iontophoresis of Avastin(r) and Lucentis(r) for the treatment of choroidal neovascularization in a disease treatment model...
  29. Follow-up Study: Comparison of AMD Treatments Trial (CATT)
    Maureen G Maguire; Fiscal Year: 2013
    ..Patients who were enrolled and treated for 2 years for choroidal neovascularization within the CATT randomized clinical will return to one of 42 CATT clinical centers for measurement of ..
  30. Genetic Epidemiology of Refractive Error
    DWIGHT EDWARD STAMBOLIAN; Fiscal Year: 2013
    ..Such complications include choroidal neovascularization, retinal detachment and glaucoma. Glaucoma is a complication of myopia;prevalence of glaucoma is 4...
  31. PREPROSTAGLANDIN ENDOPEROXIDES
    ROBERT GERD SALOMON; Fiscal Year: 2013
    ..Some of these, e.g., carboxyethyl- pyrroles (CEPs), promote the angiogenesis involved in choroidal neovascularization, the primary cause of severe vision loss in individuals with age-related macular degeneration (AMD)...
  32. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    ALEXANDER GEORG MARNEROS; Fiscal Year: 2011
    b>Choroidal neovascularization (CNV) in age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide...
  33. Membrane complement regulators in RPE degeneration and retinal injury
    Wenchao Song; Fiscal Year: 2013
    ..Although mouse models have been developed to study the role of complement in wet AMD with choroidal neovascularization (CNV) as an endpoint, and several anti-complement agents are being evaluated in clinical trials for wet ..
  34. Biocompatibility of thermo-responsive hydrogel ocular drug delivery system
    JENNIFER J KANG MIELER; Fiscal Year: 2010
    ..efficacy of released anti-VEGF from the hydrogels to suppress angiogenic responses in a laser-induced choroidal neovascularization rodent model...
  35. iPS cell enabled therapy for geographic atrophy
    Shuyuan Yao; Fiscal Year: 2010
    ..Severe vision loss from AMD results from choroidal neovascularization (CNV), the invasion of the retina by abnormal blood vessels, or from GA, the apoptotic loss of retinal ..
  36. Suprachroidal Drug Delivery for Retina Disorders
    Mark R Prausnitz; Fiscal Year: 2013
    ..This project will study drug delivery to the SCS to improve treatment of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD), which is the leading cause of blindness ..
  37. Novel TLR3 inhibitors for geographic atrophy of age-related macular degeneration
    Jayakrishna Ambati; Fiscal Year: 2010
    ..Blindness in AMD occurs due to either choroidal neovascularization (CNV) or geographic atrophy (GA)...
  38. Complement Inhibitors for Macular Degeneration
    REKHA BANSAL; Fiscal Year: 2013
    ..greater than 25% of AMD patients will develop severe vision loss due to either geographic atrophy or Choroidal NeoVascularization (CNV), commonly known as wet AMD. CNV development derives from both inflammation and angiogenesis...
  39. The Role of Soluble Flt-1 and Raver2 in Ocular Vascular Demarcations
    Balamurali K Ambati; Fiscal Year: 2013
    ..upregulating sFlt-1 suppressed suture-induced corneal neovascularization and laser-induced choroidal neovascularization, and improve cornea transplant survival...
  40. Crystalline Antiproliferative Drugs for Intraocular Diseases
    William R Freeman; Fiscal Year: 2011
    ..approach include retinal detachment due to trauma and proliferative vitreoretinopathy as well as choroidal neovascularization in age related macular degeneration...
  41. AN EXPERIMENTAL APPROACH TO MACULOPATHY
    David R Hinton; Fiscal Year: 2013
    ..GA) is associated with progressive senescence and death of the retinal pigment epithelium (RPE), while choroidal neovascularization (CNV) is associated with growth of new vessels under the retina...
  42. In Vivo Molecular Imaging of the Retina
    Ashwath Jayagopal; Fiscal Year: 2013
    ..In this proposal, hAuNP will be utilized to validate mRNAs and microRNAs as biomarkers of choroidal neovascularization (CNV), using a mouse model of laser- induced choroidal neovascularization (LCNV)...
  43. The Role of Neuroprotectin D1 in Choroidal Neovascularization
    KRISTOPHER GRAYE SHEETS; Fiscal Year: 2012
    ..accounts for more than 85% of lost vision and involves abnormal retinal pigment epithelium (RPE), choroidal neovascularization (CNV), and photoreceptor atrophy...
  44. Regulation of ocular angiogenesis by microRNAs
    Shusheng Wang; Fiscal Year: 2013
    ..Specific Aim III is to determine the mechanism by which miR-126 regulates neovascularization in a laser induced choroidal neovascularization model.
  45. Retinal Therapy Guided by 3-D OCT Image Analysis
    Milan Sonka; Fiscal Year: 2013
    ..treatments, especially anti-VEGF agents, have recently become available to restore visual function in choroidal neovascularization (CNV), the most severe form of AMD...
  46. Role of TIMP-3 in Ocular Neovascularization
    Bela Anand Apte; Fiscal Year: 2009
    b>Choroidal neovascularization (CNV) is the major cause of severe vision loss in patients with age-related macular degeneration (AMD)...
  47. Molecular Mechanisms Underlying Macular Degenerations
    Radha Ayyagari; Fiscal Year: 2011
    ..by central vision loss associated with atrophy of retinal pigment epithelium with or without choroidal neovascularization. Understanding the mechanisms underlying these debilitating diseases will help design therapeutic ..
  48. Sulfated Polysaccharide Derivatives for Treatment of Macular Degeneration
    Jianxing Zhang; Fiscal Year: 2009
    ..from in vitro experiments, in Aim 4 we will the determine feasilibity of blocking VEGF-mediated choroidal neovascularization in mice using a laser photocoagulation model...
  49. Low Cost Device for Detection of Retinal Disease
    Benno L Petrig; Fiscal Year: 2012
    ..Applications include early detection of choroidal neovascularization, detection of cystoid macular edema, investigating macular sparing, mapping the Preferred Retinal Locus,..
  50. Vascular Progenitor Cells in Neovascular AMD
    Scott W Cousins; Fiscal Year: 2012
    ..The major cause of severe vision loss in AMD is choroidal neovascularization (CNV) or the growth of new vessels under the retina...
  51. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..Discovering the major determinants in cancer progression for the development of more efficacious therapies is therefore extremely important to society. ..
  52. Novel Treatment for Degenerative Myopia
    JULIA KORNFIELD; Fiscal Year: 2009
    ..While visual loss from macular atrophy and choroidal neovascularization are most common in degenerative myopia, patients with this disease are also more prone to retinal ..
  53. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2007
    ..Preliminary Data: (1) CCL2-/- and CCR2-/- mice develop lipofuscin, drusen, geographic atrophy, and choroidal neovascularization (CNV) as they age...
  54. Photograph Reading Center for the Comparison of AMD Treatments Trial
    Juan E Grunwald; Fiscal Year: 2013
    ..support includes A) the evaluation of follow-up visit fundus photographs to assess the changes in the choroidal neovascularization and the changes in retinal vessel diameters following both treatments;and B) assessment of the ..
  55. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..research objective of this grant proposal is to understand the biochemical mechanisms that lead to choroidal neovascularization (CNV)...
  56. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..resulting from diabetic retinopathy is the most common cause of new blindness in young patients, and choroidal neovascularization (CNV) resulting from AMD is the chief cause of severe and irreversible loss of vision in elderly ..
  57. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2007
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  58. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2004
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  59. Nonpeptide Somatostatin Agonists for Retinopathy
    Maria Grant; Fiscal Year: 2005
    ..Similarly, choroidal neovascularization is seen in age-related macular degeneration (ARMD), which is the leading cause of blindness in the ..
  60. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
    ..implicate a central role for complement activation in the pathogenesis of AMD, and especially of choroidal neovascularization (CNV) the most serious form of AMD...
  61. Redox protein APE1/Ref-1 as a target for age-related macular degeneration (AMD)
    MARTIN HASLANGER; Fiscal Year: 2009
    ..using in vitro retinal endothelial cells and in vivo animal models of AMD with subretinal and choroidal neovascularization. The hypothesis of the proposed research is that blocking APE1/Ref-1 redox function will lead to ..
  62. CONFOCAL INTEGRATED INSTRUMENT SYSTEM
    Steven Bassnett; Fiscal Year: 2010
    ..User Group are engaged in fundamental research into the causes and treatment of retinal degeneration, choroidal neovascularization, herpetic eye infections, cataract and corneal dystrophies...
  63. LASER HEMOSTASIS WITH SILICON NAPHTHALOCYANINES
    ROBERT SCHLIER; Fiscal Year: 1991
    ..Experimental choroidal neovascularization in monkeys will be treated in Phase II.
  64. Novel Linomide Analog for Treatment of Diabetic Retinopathy
    Kangmo Lu; Fiscal Year: 2006
    ..exhibited significantly more potent specific anti-proliferative activity and suppressed experimental choroidal neovascularization (CNV) in rats...
  65. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..In patients with AMD new vessel growth (angiogenesis) beneath the retina from the underlying choroid (choroidal neovascularization or CNV) is the major or cause of severe visual loss in these patients...
  66. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    ..We have demonstrated that TIMP-3 is an inhibitor of angiogenesis. Since choroidal neovascularization is a prominent feature of SFD we propose that TIMP-3 mutations in SFD may affect it s angiostatic ..