choroidal neovascularization

Summary

Summary: A pathological process consisting of the formation of new blood vessels in the CHOROID.

Top Publications

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
  2. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
  3. doi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
  4. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
  5. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
  6. doi Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials
    P Mitchell
    Eye Clinic B4A, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145, Australia
    Br J Ophthalmol 94:2-13. 2010
  7. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
  8. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
  9. doi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
  10. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009

Detail Information

Publications280 found, 100 shown here

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
    ..Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration...
  2. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
    ....
  3. doi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
    To evaluate the efficacy and safety of ranibizumab administered monthly for three months and then quarterly in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  4. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    ..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
  5. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
    ..In humans with AMD, MCs accumulated in the subretinal space at sites of retinal degeneration and choroidal neovascularization (CNV)...
  6. doi Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials
    P Mitchell
    Eye Clinic B4A, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145, Australia
    Br J Ophthalmol 94:2-13. 2010
    ..Ranibizumab is approved for treating neovascular AMD. However, further guidance is needed to assist ophthalmologists in clinical practice to optimise treatment outcomes...
  7. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
    There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models...
  8. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
    ..Moreover, miR-23 and miR-27 are required for pathological angiogenesis in a laser-induced choroidal neovascularization mouse model...
  9. doi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
    ..To compare choroidal thickness between eyes with polypoidal choroidal vasculopathy (PCV) and eyes with age-related macular degeneration (AMD)...
  10. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
    ..to develop drusen and phenotypic features similar to AMD, including an increased susceptibility to choroidal neovascularization (CNV)...
  11. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ..with verteporfin (VISUDYNE) photodynamic therapy (PDT) in patients with predominantly classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) were retrospectively analyzed to identify ..
  12. pmc Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization
    Juan Amaral
    Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0608, USA
    Invest Ophthalmol Vis Sci 51:1318-26. 2010
    ..Here, they examined the effects of PEDF polypeptide fragments on vessel sprouting and on choroidal neovascularization (CNV) after subconjunctival administration.
  13. ncbi Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population
    Norimoto Gotoh
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Clin Experiment Ophthalmol 36:437-42. 2008
    ....
  14. doi Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration
    Susan B Bressler
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ophthalmology 116:S1-7. 2009
    ..Basic and clinical research implicates VEGF in the pathogenesis of choroidal neovascularization (CNV), although other candidate factors involved with regulation of angiogenesis exist...
  15. ncbi Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium
    Takeshi Fujimoto
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 51:4694-702. 2010
    b>Choroidal neovascularization (CNV) is directly related to visual loss in persons with age-related macular degeneration (AMD) and other macular disorders...
  16. ncbi Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization
    Michael J Tolentino
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Retina 24:132-8. 2004
    To determine the safety and efficacy of small interfering RNA (siRNA) directed against vascular endothelial growth factor (VEGF) in a nonhuman primate model of laser-induced choroidal neovascularization (CNV).
  17. ncbi A novel imaging technique for experimental choroidal neovascularization
    Mercedes Campos
    Biological Imaging Core, National Eye Institute, NIH, Bethesda, Maryland 20892 0703, USA
    Invest Ophthalmol Vis Sci 47:5163-70. 2006
    b>Choroidal neovascularization (CNV) is the end point of several ocular diseases that lead to blindness...
  18. ncbi Clinical characteristics of exudative age-related macular degeneration in Japanese patients
    Ichiro Maruko
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Ophthalmol 144:15-22. 2007
    ..To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients...
  19. ncbi Perspectives of choroidal neovascularization therapy
    M Caputo
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Italy
    Curr Drug Targets 12:234-42. 2011
    Vision loss secondary to Choroidal Neovascularization (CNV) is becoming a major disease condition in developed world...
  20. pmc The association of age-related maculopathy susceptibility 2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Vis 17:977-82. 2011
    ....
  21. pmc Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
    Kanako Izumi-Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:2149-58. 2007
    Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with age-related macular degeneration; however, the ..
  22. ncbi Subtype lesions of neovascular age-related macular degeneration in Chinese patients
    Yan Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou 510060, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 245:1441-5. 2007
    ..To identify the subtype frequency and clinical features of neovascular age-related macular degeneration (AMD) in Chinese patients...
  23. ncbi The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization
    Chikako Tsutsumi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Leukoc Biol 74:25-32. 2003
    b>Choroidal neovascularization (CNV) is directly related to visual loss in some eye diseases, such as age-related macular degeneration...
  24. ncbi Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    Napoleone Ferrara
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Retina 26:859-70. 2006
    ..Among these, ranibizumab is a high affinity recombinant Fab that neutralizes all isoforms of VEGF-A. The article briefly reviews the biology of VEGF and then focuses on the path that led to clinical development of ranibizumab...
  25. ncbi Clinicopathologic findings in polypoidal choroidal vasculopathy
    Hiroyuki Nakashizuka
    Department of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:4729-37. 2008
    ..To elucidate the pathogenic mechanism of polypoidal choroidal vasculopathy (PCV) based on histopathologic findings...
  26. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ..of polypoidal choroidal vasculopathy (PCV) in Japanese patients presumed to have age-related macular degeneration (AMD) and compare 1-year outcomes after photodynamic therapy between PCV and choroidal neovascularization secondary to AMD.
  27. pmc A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions
    Hui Yuan Hou
    Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Mol Ther 18:1837-45. 2010
    b>Choroidal neovascularization (CNV) is a common cause of severe and irreversible visual loss; however, the treatment of CNV has been hindered by its complex and poorly understood pathogenesis...
  28. doi Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments
    David B Rein
    Research Triangle Institute International, Research Triangle Park, North Carolina, USA
    Arch Ophthalmol 127:533-40. 2009
    ..To forecast age-related macular degeneration (AMD) and its consequences in the United States through the year 2050 with different treatment scenarios...
  29. pmc A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap
    Jingtai Cao
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA
    Invest Ophthalmol Vis Sci 51:6009-17. 2010
    The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV)...
  30. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010
    ..It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD...
  31. ncbi EXTEND-I: safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration
    Yasuo Tano
    Department of Ophthalmology, Osaka University Medical School, Japan
    Acta Ophthalmol 88:309-16. 2010
    To evaluate the efficacy and safety of intravitreal ranibizumab for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients.
  32. doi Intravitreal bevacizumab for subfoveal choroidal neovascularization in age-related macular degeneration at twenty-four months: the Pan-American Collaborative Retina Study
    J Fernando Arevalo
    Retina and Vitreous Service, Clinica Oftalmologica Centro Caracas, Caracas, Venezuela
    Ophthalmology 117:1974-81, 1981.e1. 2010
    ..San Francisco, CA) (1.25 or 2.5 mg) in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  33. ncbi Regression of neovascular age-related macular degeneration following infliximab therapy
    Nikos N Markomichelakis
    Ocular Inflammation and Immunology Service, Gennimatas Hospital, Athens University Medical School, Athens, Greece
    Am J Ophthalmol 139:537-40. 2005
    ..To describe the effects of the antitumor necrosis factor (TNF) monoclonal antibody Infliximab systemic therapy on choroidal neovacularisation (CNV) secondary to age-related macular degeneration (AMD)...
  34. pmc Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse
    Kristopher G Sheets
    Department of Ophthalmology and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Vis 16:320-9. 2010
    ..the effects of neuroprotectin D1 (NPD1), a stereospecific derivative of docosahexaenoic acid, on choroidal neovascularization (CNV) in a laser-induced mouse model...
  35. doi Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Jpn J Ophthalmol 54:609-14. 2010
    ..2 kb, were genotyped. Associations were tested using single-SNP and haplotype analyses...
  36. pmc Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study
    A Okubo
    Department of Ophthalmology, Kagoshima University Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Br J Ophthalmol 86:1093-8. 2002
    ..To describe the clinical and histopathological findings in a patient with polypoidal choroidal vasculopathy...
  37. ncbi A rare case of choroidal neovascularization following macular hole surgery
    S Natarajan
    Aditya Jyot Eye Hospital Pvt Ltd, Plot no 153, Road No 9, Major Parmeshwaran Road, Opp SIWS College Gate No 3, Mumbai, Wadala, 31, India
    Graefes Arch Clin Exp Ophthalmol 244:271-3. 2006
    b>Choroidal neovascularization occurs in a wide spectrum of conditions, including degenerative, inflammatory, traumatic and hereditary conditions, all of which are characterized by breaks in Bruch's membrane...
  38. pmc Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice
    Alex Jones
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 108:14578-83. 2011
    ..Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV)...
  39. doi Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy
    Kenji Yamashiro
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:8780-4. 2011
    ..To see if there is an association in Japanese between elastin gene (ELN) polymorphisms and neovascular age-related macular degeneration (AMD) or its subtypes, typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  40. doi Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization
    Julie Lecomte
    Laboratory of Tumor and Developmental Biology, Tour de Pathologie, CHU B23, Groupe Interdisciplinaire de Génoprotéomique Appliquée Research GIGA Cancer, University of Liege, 4000, Liege, Belgium
    Cell Mol Life Sci 68:677-86. 2011
    ..The contribution of MMP13 in choroidal neovascularization (CNV) formation was explored by using a murine model of laser-induced CNV and applying it to wild-type ..
  41. pmc Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization
    Heng Miao
    Department of Ophthalmology, People s Hospital, Peking University, Beijing, China
    Mol Vis 18:574-80. 2012
    ..of interleukin 1β, 6, 8, 10, 12p (IL-1β, IL-6, IL-8, IL-10, IL-12p), and tumor necrosis factor α (TNF-α) and the parameters of macular edema acquired by optical coherence tomography (OCT) in patients with choroidal neovascularization.
  42. doi In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography
    Andrea Giani
    Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3880-7. 2011
    To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT).
  43. ncbi Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model
    Philipp S Müther
    Department of Ophthalmology, University of Dusseldorf, Dusseldorf, Germany
    Invest Ophthalmol Vis Sci 51:4831-9. 2010
    ..Microglia cells have been associated with immunologic defense and repair. The course of retinal disease after lethal irradiation for bone marrow depletion and substitution was evaluated with respect to macrophage and microglial involvement...
  44. doi Metabolic physiology in age related macular degeneration
    Einar Stefansson
    University of Iceland, National University Hospital, 101 Reykjavik, Iceland
    Prog Retin Eye Res 30:72-80. 2011
    ..If the resulting hypoxia and consequent VEGF accumulation crosses a threshold, this will trigger effusion and neovascularization...
  45. ncbi Effect of bevacizumab on inflammation and proliferation in human choroidal neovascularization
    Olcay Tatar
    University Eye Hospital, Centre for Ophthalmology, Eberhard Karls University, Tubingen
    Arch Ophthalmol 126:782-90. 2008
    To evaluate the effect of bevacizumab (Avastin; Genentech, Inc, South San Francisco, California) on inflammation and proliferation in human choroidal neovascularization (CNV) secondary to age-related macular degeneration.
  46. ncbi Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization
    David N Zacks
    Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2384-91. 2002
    To develop a model of verteporfin photodynamic therapy (PDT) for experimental choroidal neovascularization CNV in the rat.
  47. ncbi Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF
    K Ohno-Matsui
    Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 189:323-33. 2001
    ..This equilibrium shift may be significant in promoting a pathological condition of RPE cells and contributing to choroidal neovascularization in age-related macular degeneration.
  48. ncbi Combination photodynamic therapy and intravitreal ranibizumab in neovascular AMD in a north Indian population: a pilot study
    Atul Kumar
    India Institute of Medical Sciences, New Delhi, India
    Retina 28:1132-7. 2008
    ..To evaluate photodynamic therapy (PDT) with verteporfin along with intravitreal Ranibizumab in treatment of neovascular age related macular degeneration...
  49. doi Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration
    Bradley T Smith
    Barnes Retina Institute, St Louis, Missouri, USA
    Retina 28:675-81. 2008
    To report the outcome for eyes treated with intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy (PDT) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD).
  50. pmc Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization
    Tailoi Chan-Ling
    Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Sydney, Australia
    Am J Pathol 168:1031-44. 2006
    ..We have shown that adult HSCs differentiate into endothelial cells and participate in both retinal and choroidal neovascularization. We asked whether HSCs participated in the wounding response by forming astrocytes, retinal pigment ..
  51. pmc Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone
    P P Yip
    Department of Ophthalmology, Tuen Mun Hosptial, Tsing Chung Koon Road, Tuen Mun, Hong Kong
    Br J Ophthalmol 93:754-8. 2009
    ..FA was repeated at 3 and 6 months. Outcome measures included visual improvement measured by logMAR equivalent, angiographic evident of leakage and safety profile...
  52. ncbi Current concepts in the pathogenesis of age-related macular degeneration
    Marco A Zarbin
    Institute of Ophthalmology and Visual Science at the New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 90 Bergen Street, Suite 6100, Newark, NJ 07103 2499, USA
    Arch Ophthalmol 122:598-614. 2004
    ..To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD)...
  53. ncbi Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107, USA
    Arch Ophthalmol 123:1658-66. 2005
    To evaluate choroidal osteoma for tumor growth, tumor decalcification, related choroidal neovascularization, visual acuity loss, and poor visual acuity.
  54. ncbi Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration: a report by the American Academy of Ophthalmology
    Michael S Ip
    American Academy of Ophthalmology, Box 7424, San Francisco, CA 94120, USA
    Ophthalmology 115:1837-46. 2008
    ..To examine the evidence about the safety and efficacy of anti-vascular endothelial growth factor (VEGF) pharmacotherapies for the treatment of neovascular age-related macular degeneration (AMD)...
  55. ncbi Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration
    Domniki N Papadopoulou
    Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
    Ophthalmology 116:1755-61. 2009
    ..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
  56. ncbi Vision-related function after ranibizumab treatment by better- or worse-seeing eye: clinical trial results from MARINA and ANCHOR
    Neil M Bressler
    Retina Division, Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0005, USA
    Ophthalmology 117:747-56.e4. 2010
    ....
  57. doi Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population
    Xiaoqi Liu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Retina 30:1177-84. 2010
    ..Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population...
  58. pmc Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
    S R Singh
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    Gene Ther 16:645-59. 2009
    b>Choroidal neovascularization (CNV) leads to loss of vision in age-related macular degeneration (AMD), the leading cause of blindness in adult population over 50 years old...
  59. ncbi Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment--TAP and VIP report No. 2
    Irene Barbazetto
    Medizinische Universitat zu Lubeck, Klinik fur Augenheilkunde, Lubeck, Germany
    Arch Ophthalmol 121:1253-68. 2003
    ..fluorescein angiographic guidelines for the use of verteporfin therapy in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) or other conditions based on 2-year vision ..
  60. ncbi Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation
    J L Colquitt
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 12:iii-iv, ix-201. 2008
    ..To assess the clinical effectiveness and cost-effectiveness of ranibizumab and pegaptanib for subfoveal choroidal neovascularisation (CNV) associated with wet age-related macular degeneration (AMD)...
  61. ncbi Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration
    Murat V Kalayoglu
    Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Graefes Arch Clin Exp Ophthalmol 243:1080-90. 2005
    ..pneumoniae. These data indicate that a pathogen capable of inducing chronic inflammation and pro-angiogenic cytokines can be detected in some AMD CNV, and suggest that infection may contribute to the pathogenesis of AMD...
  62. ncbi Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy
    F Gomi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:70-3. 2008
    ..The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV)...
  63. ncbi The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration
    Salvatore Grisanti
    Department of Ophthalmology at the University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Prog Retin Eye Res 27:372-90. 2008
    ..Similarly, the reason for progression into two distinct late forms which are "geographic atrophy" and "choroidal neovascularization" remains enigmatic...
  64. ncbi Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration
    Imran A Bhutto
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 9115, USA
    Exp Eye Res 82:99-110. 2006
    ..The decrease in PEDF may disrupt the balance and be permissive for the formation of choroidal neovascularization (CNV) in AMD.
  65. doi Suppression of choroidal neovascularization by N-acetyl-cysteine in mice
    Ryuhei Hara
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Curr Eye Res 35:1012-20. 2010
    N-acetyl-cysteine (NAC) is a potent antioxidant known to be a precursor of glutathione. The purpose of this study was to investigate the role of NAC in the development of choroidal neovascularization (CNV).
  66. pmc Genetic loci that control the size of laser-induced choroidal neovascularization
    Kei Nakai
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 23:2235-43. 2009
    ..To investigate the genetic contribution to choroidal neovascularization (CNV), a leading cause of blindness, we have undertaken a similar mapping approach to identify QTLs ..
  67. doi Differences in the temporal expression of regulatory growth factors during choroidal neovascular development
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202 5175, USA
    Exp Eye Res 88:79-91. 2009
    ..have been well characterized in certain tissues, their particular functions and expression patterns in choroidal neovascularization (CNV) have not been clearly established...
  68. ncbi Nicotine increases size and severity of experimental choroidal neovascularization
    Ivan J Suner
    Department of Ophthalmology, Miami Veterans Affairs Medical Center, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 45:311-7. 2004
    ..In the present study, the influence of nicotine on the severity of choroidal neovascularization (CNV) in a mouse model of neovascular AMD and its effects on vascular smooth muscle cells derived from ..
  69. pmc Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344
    Ping Xie
    Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 6:e28933. 2011
    To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal neovascularization (CNV).
  70. ncbi Combination treatment with intravitreal injection of ranibizumab and reduced fluence photodynamic therapy for choroidal neovascularization secondary to angioid streaks: preliminary clinical results of 12-month follow-up
    Ozgur Artunay
    Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey
    Retina 31:1279-86. 2011
    To evaluate combination treatment with intravitreal ranibizumab injection and reduced fluence photodynamic therapy for choroidal neovascularization associated with angioid streaks.
  71. ncbi Choroidal neovascularization in retinochoroidal coloboma: thermal laser treatment achieves long-term stabilization of visual acuity
    M Spitzer
    Eye (Lond) 20:969-72. 2006
  72. ncbi Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin
    Wai Man Chan
    Hong Kong Eye Hospital, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Ophthalmol 143:977-983. 2007
    To evaluate the safety and efficacy of intravitreal bevacizumab in the treatment of idiopathic choroidal neovascularization (CNV) and CNV secondary to central serous chorioretinopathy (CSC) or punctate inner choroidopathy (PIC).
  73. pmc Combined photodynamic therapy and intravitreal triamcinolone injection for the treatment of choroidal neovascularisation secondary to pathological myopia: a pilot study
    Javier A Montero
    Br J Ophthalmol 91:131-3. 2007
  74. pmc Vascular adhesion protein-1 blockade suppresses choroidal neovascularization
    Kousuke Noda
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    FASEB J 22:2928-35. 2008
    ..Leukocytes and, in particular, macrophages play an important role in the development of choroidal neovascularization (CNV), an integral component of age-related macular degeneration (AMD)...
  75. doi Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Invest Ophthalmol Vis Sci 49:3100-6. 2008
    ..genetic polymorphisms explain the variable clinical outcomes of photodynamic therapy with verteporfin (PDT-V) in Caucasian patients with occult subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD).
  76. ncbi Clinical features and prognosis in ocular toxoplasmosis
    Leyla S Atmaca
    Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey
    Jpn J Ophthalmol 48:386-91. 2004
    ..To evaluate retrospectively the clinical characteristics, complications, and prognosis in patients with ocular toxoplasmosis...
  77. doi SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation
    Eoin Guerin
    Unit of Ophthalmology, Department of Clinical Sciences, UCD, Duncan Building, University of Liverpool, Daulby Street, Liverpool, L69 3GA, United Kingdom
    Microvasc Res 75:302-7. 2008
    ..05). CXCR4 immunostaining was widespread in all membranes in keeping with the published work of other investigators. Our study suggests that SDF, which may be produced by the RPE, could play a role in CNV...
  78. pmc Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation
    Xiufeng Zhong
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Vis 17:492-507. 2011
    ..The present study was conducted to evaluate the effect of overexpression of VEGF-B via adeno-associated virus (AAV) gene transfer on ocular angiogenesis, inflammation, and the blood-retinal barrier (BRB)...
  79. ncbi Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, Center Study for Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    Pharmacogenet Genomics 17:1039-46. 2007
    ..majority of severe vision loss occurs in the exudative form of AMD, characterized by the development of choroidal neovascularization (CNV) beneath the fovea...
  80. ncbi Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization
    Eiji Sakurai
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Invest Ophthalmol Vis Sci 44:2743-9. 2003
    To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV).
  81. ncbi Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization
    Haicheng She
    Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:2268-77. 2007
    To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV).
  82. pmc Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice
    Nalini S Bora
    Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 285:33826-33. 2010
    ..on the growth and size of fully developed neovascular complex using the murine model of laser-induced choroidal neovascularization (CNV)...
  83. pmc Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization
    Nilanjana Sengupta
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Invest Ophthalmol Vis Sci 51:2697-704. 2010
    ..The authors examined the interaction between insulinlike growth factor (IGF)-1, vascular endothelial growth factor (VEGF), and stromal derived factor (SDF)-1 in vivo and in vitro using angiogenesis models...
  84. ncbi Short-term effectiveness of intravitreal bevacizumab versus ranibizumab injections for patients with neovascular age-related macular degeneration
    Tom S Chang
    Retina Institute of California, Pasadena, California 91105
    Retina 29:1235-41. 2009
    ..To compare the effectiveness of three consecutive intravitreal injections of bevacizumab (Avastin) and ranibizumab (Lucentis) in patients with treatment-naïve neovascular age-related macular degeneration...
  85. doi Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization?
    Fang Lu
    Department of Ophthalmology and Visual Science, Yale University, School of Medicine, 40 Temple Street, Suite 3D, New Haven, CT 06510, USA
    Graefes Arch Clin Exp Ophthalmol 247:171-7. 2009
    Vascular endothelial growth factor (VEGF) is an important stimulator of choroidal neovascularization (CNV)...
  86. doi Intravitreal ranibizumab for the primary treatment of choroidal neovascularization secondary to pathologic myopia
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, People s Republic of China
    Retina 29:750-6. 2009
    To evaluate the efficacy of intravitreal ranibizumab for the primary treatment of myopic choroidal neovascularization (CNV).
  87. pmc CCR3 is a target for age-related macular degeneration diagnosis and therapy
    Atsunobu Takeda
    Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 460:225-30. 2009
    ..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition...
  88. ncbi Choroidal neovascularization
    Hans E Grossniklaus
    Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Ophthalmol 137:496-503. 2004
    To review clinicopathologic findings of choroidal neovascularization (CNV) in a historical framework with emphasis on pathobiology and correlation with treatment.
  89. ncbi Vitreous levels of bevacizumab and vascular endothelial growth factor-A in patients with choroidal neovascularization
    Qi Zhu
    Centre for Ophthalmology, Eberhard Karls University, University Eye Hospital, Tubingen, Germany
    Ophthalmology 115:1750-5, 1755.e1. 2008
    To investigate the vitreous levels of bevacizumab and vascular endothelial growth factor-A (VEGF-A) after intravitreal injection of the drug in patients with choroidal neovascularization (CNV).
  90. ncbi Comparative assessment of photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a multicenter study in Hyogo prefecture, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmologica 223:333-8. 2009
    ..We aimed to evaluate the effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degenerations (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  91. ncbi Identification of a novel vascular endothelial growth factor receptor 2 inhibitor and its effect for choroidal neovascularization in vivo
    Hidenori Takahashi
    Department of Ophthalmology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Curr Eye Res 33:1002-10. 2008
    To select a novel orally administered VEGFR-2 (KDR/flk-1) specific tyrosine kinase inhibitor in a murine model of choroidal neovascularization (CNV).
  92. ncbi Effects of ranibizumab in patients with subfoveal choroidal neovascularization attributable to age-related macular degeneration
    Simon P Rothenbuehler
    Bern Photographic Reading Center, Universitätsklinik für Augenheilkunde, Inselspital, University Bern, Bern, Switzerland
    Am J Ophthalmol 147:831-7. 2009
    ....
  93. ncbi Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development
    Stanley A Vinores
    Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9289, USA
    J Cell Physiol 206:749-58. 2006
    ..These data suggest that induction of VEGF through the HRE in its promoter is critical for retinal and CNV, but not for retinal vascular development...
  94. ncbi Intravitreal bevacizumab for subfoveal idiopathic choroidal neovascularization
    Subrata Mandal
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India
    Arch Ophthalmol 125:1487-92. 2007
    To evaluate the short-term visual and anatomical outcomes and safety of intravitreal bevacizumab in subfoveal idiopathic choroidal neovascularization.
  95. ncbi Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist
    Naoyasu Umeda
    The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 9277, USA
    Mol Pharmacol 69:1820-8. 2006
    ..In this study, we found strong up-regulation of alpha(5)beta(1) in choroidal neovascularization. Implantation of an osmotic pump delivering 1.5 or 10 microg/h ( approximately 1...
  96. pmc Intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation secondary to pathological myopia
    Izumi Yamamoto
    New England Eye Center, Tufts University School of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 450, Boston, MA 02111, USA
    Br J Ophthalmol 91:157-60. 2007
    ..To evaluate the safety and efficacy of intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation (CNV) due to pathological myopia...
  97. ncbi Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation
    Sanjay R Kedhar
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Retina 27:1174-9. 2007
    ..To compare the clinical characteristics at presentation of multifocal choroiditis with panuveitis (MFCPU) and punctate inner choroidopathy (PIC)...
  98. pmc Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin)
    S K Gibran
    St Paul s Eye Unit, Royal Liverpool Hospital, Liverpool L7 8XP, UK
    Br J Ophthalmol 91:602-4. 2007
    ..To report the findings in a patient treated by repeated intravitreal bevacizumab (Avastin) injections, followed by macular relocation and excision of subfoveal choroidal neovascular membrane (CNV)...
  99. ncbi Intravitreal bevacizumab for the management of choroidal neovascularization in pseudoxanthoma elasticum
    Pawan Bhatnagar
    LuEsther T Mertz Retina Research Center of the Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA
    Retina 27:897-902. 2007
    To determine the results of intravitreal bevacizumab injections for the management of choroidal neovascularization (CNV) in patients with pseudoxanthoma elasticum (PXE)-associated angioid streaks.
  100. ncbi Short-term efficacy and safety of intravitreal ranibizumab for myopic choroidal neovascularization
    Rufino M Silva
    Department of Ophthalmology, University Hospital of Coimbra, Portugal
    Retina 28:1117-23. 2008
    To evaluate the safety and efficacy of intravitreal ranibizumab in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM).
  101. ncbi Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats
    Ryuichi Ideta
    Department of Ophthalmology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 557:21-5. 2004
    Exudative age-related macular degeneration, characterized by choroidal neovascularization (CNV), is a major cause of visual loss...

Research Grants88

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Some studies suggest that if the development of new blood vessels (choroidal neovascularization, or CNV) is detected early, treatment could be started sooner, which may help prevent visual loss...
  2. The wnt signaling pathway in choroidal neovascularization
    Jian Xing Ma; Fiscal Year: 2009
    b>Choroidal neovascularization (CNV) is a severe complication of age-related macular degeneration (AMD)...
  3. The wnt signaling pathway in choroidal neovascularization
    Jian Xing Ma; Fiscal Year: 2010
    b>Choroidal neovascularization (CNV) is a severe complication of age-related macular degeneration (AMD)...
  4. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2001
    ..depending upon the type of lesion and the findings from earlier clinical trials of treatment of choroidal neovascularization. The primary outcome for each trial will be change in visual acuity from baseline to the two-year ..
  5. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2000
    ..depending upon the type of lesion and the findings from earlier clinical trials of treatment of choroidal neovascularization. The primary outcome for each trial will be change in visual acuity from baseline to the two-year ..
  6. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2000
    ..depending upon the type of lesion and the findings from earlier clinical trials of treatment of choroidal neovascularization. The primary outcome for each trial will be change in visual acuity from baseline to the two-year ..
  7. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 1999
    ..depending upon the type of lesion and the findings from earlier clinical trials of treatment of choroidal neovascularization. The primary outcome for each trial will be change in visual acuity from baseline to the two-year ..
  8. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..g. diabetic retinopathy, retinal vein occlusions, and choroidal neovascularization associated with age-related macular degeneration (AMD))...
  9. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..b>Choroidal neovascularization (CNV), the pathologic creation of new blood vessels in the choroid layer of the eye, is a principal ..
  10. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..Discovering the major determinants in cancer progression for the development of more efficacious therapies is therefore extremely important to society. ..
  11. Sulfated Polysaccharide Derivatives for Treatment of Macular Degeneration
    Jianxing Zhang; Fiscal Year: 2009
    ..from in vitro experiments, in Aim 4 we will the determine feasilibity of blocking VEGF-mediated choroidal neovascularization in mice using a laser photocoagulation model...
  12. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  13. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  14. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  15. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  16. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  17. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
    ..correction, the increased axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  18. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2010
    ..Laser-induced choroidal neovascularization in mutant eyes is significantly enhanced compared to control eyes...
  19. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Olsen; Fiscal Year: 2009
    ..Laser-induced choroidal neovascularization in mutant eyes is significantly enhanced compared to control eyes...
  20. Novel Treatment for Degenerative Myopia
    JULIA KORNFIELD; Fiscal Year: 2009
    ..While visual loss from macular atrophy and choroidal neovascularization are most common in degenerative myopia, patients with this disease are also more prone to retinal ..
  21. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..The overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels into the retina...
  22. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2009
    ..The overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels into the retina...
  23. Genetic Epidemiology of Refractive Error
    DWIGHT EDWARD STAMBOLIAN; Fiscal Year: 2010
    ..Such complications include choroidal neovascularization, retinal detachment and glaucoma. Glaucoma is a complication of myopia;prevalence of glaucoma is 4...
  24. Genetic Epidemiology of Refractive Error
    DWIGHT EDWARD STAMBOLIAN; Fiscal Year: 2011
    ..Such complications include choroidal neovascularization, retinal detachment and glaucoma. Glaucoma is a complication of myopia;prevalence of glaucoma is 4...
  25. Crystalline Antiproliferative Drugs for Intraocular Diseases
    William Freeman; Fiscal Year: 2009
    ..approach include retinal detachment due to trauma and proliferative vitreoretinopathy as well as choroidal neovascularization in age related macular degeneration...
  26. Crystalline Antiproliferative Drugs for Intraocular Diseases
    William R Freeman; Fiscal Year: 2010
    ..approach include retinal detachment due to trauma and proliferative vitreoretinopathy as well as choroidal neovascularization in age related macular degeneration...
  27. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2004
    ..Preliminary Data: (1) CCL2-/- and CCR2-/- mice develop lipofuscin, drusen, geographic atrophy, and choroidal neovascularization (CNV) as they age...
  28. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2007
    ..Preliminary Data: (1) CCL2-/- and CCR2-/- mice develop lipofuscin, drusen, geographic atrophy, and choroidal neovascularization (CNV) as they age...
  29. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2006
    ..Preliminary Data: (1) CCL2-/- and CCR2-/- mice develop lipofuscin, drusen, geographic atrophy, and choroidal neovascularization (CNV) as they age...
  30. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2005
    ..Preliminary Data: (1) CCL2-/- and CCR2-/- mice develop lipofuscin, drusen, geographic atrophy, and choroidal neovascularization (CNV) as they age...
  31. Complement Factor H Haplotypes and Smoking in Age-Related Macular Degeneration
    Baerbel Rohrer; Fiscal Year: 2011
    ..Current available treatments focus on the late stage of the disease (choroidal neovascularization;CNV);however, those come with significant risks and only target subpopulations of AMD patients...
  32. Genetic Epidemiology of Refractive Error
    DWIGHT EDWARD STAMBOLIAN; Fiscal Year: 2012
    ..Such complications include choroidal neovascularization, retinal detachment and glaucoma. Glaucoma is a complication of myopia;prevalence of glaucoma is 4...
  33. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2010
    ..These mice develop sub-retinal pigment epithelium (RPE) deposits, RPE atrophy and choroidal neovascularization. Importantly, these changes require the presence of all three risk factors...
  34. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2009
    ..These mice develop sub-retinal pigment epithelium (RPE) deposits, RPE atrophy and choroidal neovascularization. Importantly, these changes require the presence of all three risk factors...
  35. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..resulting from diabetic retinopathy is the most common cause of new blindness in young patients, and choroidal neovascularization (CNV) resulting from AMD is the chief cause of severe and irreversible loss of vision in elderly ..
  36. Biocompatibility of thermo-responsive hydrogel ocular drug delivery system
    JENNIFER J KANG MIELER; Fiscal Year: 2010
    ..efficacy of released anti-VEGF from the hydrogels to suppress angiogenic responses in a laser-induced choroidal neovascularization rodent model...
  37. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2001
    ..research objective of this grant proposal is to understand the biochemical mechanisms that lead to choroidal neovascularization (CNV)...
  38. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2010
    ..two mouse models of ocular angiogenesis: the corneal neovascularization model, and a laser-induced choroidal neovascularization model...
  39. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2010
    ..two mouse models of ocular angiogenesis: the corneal neovascularization model, and a laser-induced choroidal neovascularization model...
  40. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    Michael Rogers; Fiscal Year: 2009
    ..two mouse models of ocular angiogenesis: the corneal neovascularization model, and a laser-induced choroidal neovascularization model...
  41. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2003
    ..research objective of this grant proposal is to understand the biochemical mechanisms that lead to choroidal neovascularization (CNV)...
  42. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
    ..inhibit pathologic angiogenesis in murine models of hyperoxic induced retinal vascular disease and choroidal neovascularization. These studies provide the first proof of concept that blocking HTRA1 is an effective therapeutic ..
  43. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2002
    ..research objective of this grant proposal is to understand the biochemical mechanisms that lead to choroidal neovascularization (CNV)...
  44. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..research objective of this grant proposal is to understand the biochemical mechanisms that lead to choroidal neovascularization (CNV)...
  45. MT1-MMP-based Animal Model of Age-related Macular Degeneration (AMD)
    George Inana; Fiscal Year: 2010
    ..There are two forms of AMD, the dry and the wet form, the latter being associated with choroidal neovascularization (CNV) and responsible for 90% of the blindness. AMD is a complex disease involving multiple genes...
  46. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2004
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  47. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2003
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  48. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2007
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  49. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2006
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  50. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2005
    ..This new treatment will use natural human peptides and will be less invasive. This new therapy, if successful, can prevent vision loss from macular edema in diabetic patients. ..
  51. Intrinsic anti-angiogenic activity of siRNA
    Jayakrishna Ambati; Fiscal Year: 2010
    ..The first clinical trials of siRNA were initiated in patients with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD), which is the leading cause of blindness among the ..
  52. Intrinsic anti-angiogenic activity of siRNA
    Jayakrishna Ambati; Fiscal Year: 2009
    ..The first clinical trials of siRNA were initiated in patients with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD), which is the leading cause of blindness among the ..
  53. Intrinsic anti-angiogenic activity of siRNA
    Jayakrishna Ambati; Fiscal Year: 2009
    ..The first clinical trials of siRNA were initiated in patients with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD), which is the leading cause of blindness among the ..
  54. AGE RELATED MACULAR DEGENERATION--PHOTODYNAMIC THERAPY
    Paul Bernstein; Fiscal Year: 2000
    ..of two dose levels of tin ethyl etiopurpurin with photodynamic therapy for the treatment of subfoveal choroidal neovascularization in patients with age-related macular degeneration...
  55. Nonpeptide Somatostatin Agonists for Retinopathy
    Maria Grant; Fiscal Year: 2005
    ..Similarly, choroidal neovascularization is seen in age-related macular degeneration (ARMD), which is the leading cause of blindness in the ..
  56. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
    ..implicate a central role for complement activation in the pathogenesis of AMD, and especially of choroidal neovascularization (CNV) the most serious form of AMD...
  57. Nonpeptide Somatostatin Agonists for Retinopathy
    Maria Grant; Fiscal Year: 2004
    ..Similarly, choroidal neovascularization is seen in age-related macular degeneration (ARMD), which is the leading cause of blindness in the ..
  58. MASP-2 Therapy for Macular Degeneration
    CLARK E TEDFORD; Fiscal Year: 2010
    ..implicate a central role for complement activation in the pathogenesis of AMD, and especially of choroidal neovascularization (CNV), the most serious form of AMD...
  59. Targeting gamma-secretase activation for anti-angiogenesis
    Michael Boulton; Fiscal Year: 2009
    ..e. oxygen-induced retinopathy model, ADCaS model of retinal neovascularization and the laser-induced choroidal neovascularization model) in conjunction with agents that regulate specific ?-secretase subunits to evaluate their ..
  60. Targeting gamma-secretase activation for anti-angiogenesis
    MICHAEL EDWIN BOULTON; Fiscal Year: 2010
    ..e. oxygen-induced retinopathy model, ADCaS model of retinal neovascularization and the laser-induced choroidal neovascularization model) in conjunction with agents that regulate specific ?-secretase subunits to evaluate their ..
  61. Targeting gamma-secretase activation for anti-angiogenesis
    Michael Boulton; Fiscal Year: 2007
    ..e. oxygen-induced retinopathy model, ADCaS model of retinal neovascularization and the laser-induced choroidal neovascularization model) in conjunction with agents that regulate specific ?-secretase subunits to evaluate their ..
  62. Targeting gamma-secretase activation for anti-angiogenesis
    Michael Boulton; Fiscal Year: 2007
    ..e. oxygen-induced retinopathy model, ADCaS model of retinal neovascularization and the laser-induced choroidal neovascularization model) in conjunction with agents that regulate specific ?-secretase subunits to evaluate their ..
  63. Targeting gamma-secretase activation for anti-angiogenesis
    Michael Boulton; Fiscal Year: 2009
    ..e. oxygen-induced retinopathy model, ADCaS model of retinal neovascularization and the laser-induced choroidal neovascularization model) in conjunction with agents that regulate specific ?-secretase subunits to evaluate their ..
  64. Redox protein APE1/Ref-1 as a target for age-related macular degeneration (AMD)
    MARTIN HASLANGER; Fiscal Year: 2009
    ..using in vitro retinal endothelial cells and in vivo animal models of AMD with subretinal and choroidal neovascularization. The hypothesis of the proposed research is that blocking APE1/Ref-1 redox function will lead to ..
  65. LASER HEMOSTASIS WITH SILICON NAPHTHALOCYANINES
    ROBERT SCHLIER; Fiscal Year: 1991
    ..Experimental choroidal neovascularization in monkeys will be treated in Phase II.
  66. Novel Linomide Analog for Treatment of Diabetic Retinopathy
    Kangmo Lu; Fiscal Year: 2006
    ..exhibited significantly more potent specific anti-proliferative activity and suppressed experimental choroidal neovascularization (CNV) in rats...
  67. Pro-and anti-angiogenic effects of vascular endothelial growth factor-A
    Jayakrishna Ambati; Fiscal Year: 2009
    ..The overwhelming cause of severe vision loss in these patients is choroidal neovascularization (CNV), the growth of abnormal blood vessels beneath the retina...
  68. Pro-and anti-angiogenic effects of vascular endothelial growth factor-A
    Jayakrishna Ambati; Fiscal Year: 2007
    ..The overwhelming cause of severe vision loss in these patients is choroidal neovascularization (CNV), the growth of abnormal blood vessels beneath the retina...
  69. MOLECULAR GENETICS OF AGE RELATED MACULAR DEGENERATION
    Edwin Stone; Fiscal Year: 1990
    ..interface of Bruch's membrane and the retinal pigment epithelium (RPE), 2) an increased incidence of choroidal neovascularization, and 3) geographic atrophy of the RPE and photoreceptors in later stages of disease...
  70. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2004
    ..b>Choroidal neovascularization occurs in cases of age-related macular degeneration, the most common cause of blindness in individuals ..
  71. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2002
    ..b>Choroidal neovascularization occurs in cases of age-related macular degeneration, the most common cause of blindness in individuals ..
  72. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2005
    ..b>Choroidal neovascularization occurs in cases of age-related macular degeneration, the most common cause of blindness in individuals ..
  73. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2003
    ..b>Choroidal neovascularization occurs in cases of age-related macular degeneration, the most common cause of blindness in individuals ..
  74. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2003
    ..b>Choroidal neovascularization occurs in cases of age-related macular degeneration, the most common cause of blindness in individuals ..
  75. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 1999
    ..In patients with AMD new vessel growth (angiogenesis) beneath the retina from the underlying choroid (choroidal neovascularization or CNV) is the major or cause of severe visual loss in these patients...
  76. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2000
    ..In patients with AMD new vessel growth (angiogenesis) beneath the retina from the underlying choroid (choroidal neovascularization or CNV) is the major or cause of severe visual loss in these patients...
  77. Novel Method for the Ocular Iontophoretic Delivery of Avastin and Lucentis
    William I Higuchi; Fiscal Year: 2010
    ..3) To establish transscleral iontophoresis of Avastin(r) and Lucentis(r) for the treatment of choroidal neovascularization in a disease treatment model...
  78. Sphingosine Kinase Inhibitors as Anti-Retinopathy Agents
    LYNN MAINES; Fiscal Year: 2007
    ..2.) To evaluate the protective effects of ABC294640 in a model of laser-induced choroidal neovascularization. 3.) To complete cGMP synthesis and IND-directed toxicology studies with ABC294640...
  79. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2001
    ..In patients with AMD new vessel growth (angiogenesis) beneath the retina from the underlying choroid (choroidal neovascularization or CNV) is the major or cause of severe visual loss in these patients...
  80. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..In patients with AMD new vessel growth (angiogenesis) beneath the retina from the underlying choroid (choroidal neovascularization or CNV) is the major or cause of severe visual loss in these patients...
  81. iPS cell enabled therapy for geographic atrophy
    Shuyuan Yao; Fiscal Year: 2010
    ..Severe vision loss from AMD results from choroidal neovascularization (CNV), the invasion of the retina by abnormal blood vessels, or from GA, the apoptotic loss of retinal ..
  82. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2009
    ..Loss of HTRA1 function will be determined by measuring the reduction of or inability for choroidal neovascularization (CNV) to take place in homozygous and heterozygous conditional KO mice...
  83. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2009
    ..Loss of HTRA1 function will be determined by measuring the reduction of or inability for choroidal neovascularization (CNV) to take place in homozygous and heterozygous conditional KO mice...
  84. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2009
    ..Loss of HTRA1 function will be determined by measuring the reduction of or inability for choroidal neovascularization (CNV) to take place in homozygous and heterozygous conditional KO mice...
  85. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    ..We have demonstrated that TIMP-3 is an inhibitor of angiogenesis. Since choroidal neovascularization is a prominent feature of SFD we propose that TIMP-3 mutations in SFD may affect it s angiostatic ..