retinal perforations

Summary

Summary: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Top Publications

  1. doi The internal limiting membrane peeling with brilliant blue G staining for retinal detachment due to macular hole in high myopia
    Y Mochizuki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, 812 8582, Japan
    Br J Ophthalmol 92:1009. 2008
  2. doi Correlation of visual recovery and presence of photoreceptor inner/outer segment junction in optical coherence images after successful macular hole repair
    Takayuki Baba
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan
    Retina 28:453-8. 2008
  3. doi Value of internal limiting membrane peeling in surgery for idiopathic macular hole and the correlation between function and retinal morphology
    Ulrik Correll Christensen
    Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark
    Acta Ophthalmol 87:1-23. 2009
  4. ncbi Tears of the retinal pigment epithelium: an old problem in a new era
    Louis K Chang
    Jules Stein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:523-34. 2007
  5. doi Value of internal limiting membrane peeling in surgery for idiopathic macular hole stage 2 and 3: a randomised clinical trial
    U C Christensen
    Department of Ophthalmology, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Br J Ophthalmol 93:1005-15. 2009
  6. pmc 25-gauge vs 20-gauge system for pars plana vitrectomy: a prospective randomised clinical trial
    Lukas Kellner
    Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Br J Ophthalmol 91:945-8. 2007
  7. pmc Relationship between macular hole size and the potential benefit of internal limiting membrane peeling
    R Tadayoni
    Service d Ophtalmologie, Hopital Lariboisiere, 2, rue Ambroise Pare, Paris, France
    Br J Ophthalmol 90:1239-41. 2006
  8. pmc Phacovitrectomy without prone posture for full thickness macular holes
    P R Simcock
    West of England Eye Unit, Royal Devon and Exeter Hospital Wonford, Barrack Road, Exeter EX2 5DW, UK
    Br J Ophthalmol 85:1316-9. 2001
  9. ncbi Clinical evaluation of the use of indocyanine green for peeling the internal limiting membrane in macular hole surgery
    Aude Husson-Danan
    Centre Hospitalier National d Ophtalmologie des Quinze Vingts, 28 rue de Charenton, 75012 Paris, France
    Graefes Arch Clin Exp Ophthalmol 244:291-7. 2006
  10. doi A comparison of brilliant blue G, trypan blue, and indocyanine green dyes to assist internal limiting membrane peeling during macular hole surgery
    Dhananjay Shukla
    Retina Vitreous Service, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Retina 31:2021-5. 2011

Research Grants

  1. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2007
  2. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2009
  3. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2010
  4. THE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYE
    Rajendra S Apte; Fiscal Year: 2010
  5. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2007
  6. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2007
  7. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
  8. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
  9. Eye Disease in Cuban-American and Puerto Rican Adults
    Ingrid Scott; Fiscal Year: 2003
  10. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2006

Detail Information

Publications229 found, 100 shown here

  1. doi The internal limiting membrane peeling with brilliant blue G staining for retinal detachment due to macular hole in high myopia
    Y Mochizuki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, 812 8582, Japan
    Br J Ophthalmol 92:1009. 2008
  2. doi Correlation of visual recovery and presence of photoreceptor inner/outer segment junction in optical coherence images after successful macular hole repair
    Takayuki Baba
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan
    Retina 28:453-8. 2008
    ....
  3. doi Value of internal limiting membrane peeling in surgery for idiopathic macular hole and the correlation between function and retinal morphology
    Ulrik Correll Christensen
    Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark
    Acta Ophthalmol 87:1-23. 2009
    ..05% isotonic ICG-assisted ILM peeling in stage 2 macular hole surgery...
  4. ncbi Tears of the retinal pigment epithelium: an old problem in a new era
    Louis K Chang
    Jules Stein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:523-34. 2007
    ..The authors review the clinical features, etiologies, imaging characteristics, and pathogenesis of RPE tears and their relationship with intravitreal anti-VEGF treatments...
  5. doi Value of internal limiting membrane peeling in surgery for idiopathic macular hole stage 2 and 3: a randomised clinical trial
    U C Christensen
    Department of Ophthalmology, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Br J Ophthalmol 93:1005-15. 2009
    ..To determine the effect of internal limiting membrane (ILM) peeling on anatomical and functional success rates in stage 2 and 3 idiopathic macular hole surgery (MHS)...
  6. pmc 25-gauge vs 20-gauge system for pars plana vitrectomy: a prospective randomised clinical trial
    Lukas Kellner
    Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Br J Ophthalmol 91:945-8. 2007
    ..To compare 25-gauge vs 20-gauge system for pars plana vitrectomy in a prospective, randomised, controlled clinical trial...
  7. pmc Relationship between macular hole size and the potential benefit of internal limiting membrane peeling
    R Tadayoni
    Service d Ophtalmologie, Hopital Lariboisiere, 2, rue Ambroise Pare, Paris, France
    Br J Ophthalmol 90:1239-41. 2006
    ..To investigate the relationship between the size of macular holes and the possible benefit of internal limiting membrane (ILM) peeling...
  8. pmc Phacovitrectomy without prone posture for full thickness macular holes
    P R Simcock
    West of England Eye Unit, Royal Devon and Exeter Hospital Wonford, Barrack Road, Exeter EX2 5DW, UK
    Br J Ophthalmol 85:1316-9. 2001
    ..To investigate the role of phacovitrectomy surgery without prone posture for stage 2 and 3 macular holes...
  9. ncbi Clinical evaluation of the use of indocyanine green for peeling the internal limiting membrane in macular hole surgery
    Aude Husson-Danan
    Centre Hospitalier National d Ophtalmologie des Quinze Vingts, 28 rue de Charenton, 75012 Paris, France
    Graefes Arch Clin Exp Ophthalmol 244:291-7. 2006
    ..To evaluate the role of indocyanine green (infracyanine) in macular hole surgery...
  10. doi A comparison of brilliant blue G, trypan blue, and indocyanine green dyes to assist internal limiting membrane peeling during macular hole surgery
    Dhananjay Shukla
    Retina Vitreous Service, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Retina 31:2021-5. 2011
    ..To compare surgical outcomes with three dyes, brilliant blue G (BBG), trypan blue (TB) and indocyanine green (ICG), used to facilitate internal limiting membrane peeling during macular hole surgery...
  11. ncbi Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography
    Belkacem Haouchine
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite, Paris, France
    Am J Ophthalmol 138:732-9. 2004
    ..To assess the usefulness of optical coherence tomography (OCT) for better differential diagnosis of macular pseudoholes (MPH) and lamellar macular holes (LMH)...
  12. ncbi Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peeling
    Hiroshi Enaida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 26:631-6. 2006
    ..To report the use of the dye brilliant blue G (BBG) for staining of the internal limiting membrane (ILM) during macular hole (MH) and epiretinal membrane (ERM) surgery...
  13. doi Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery
    Jaeryung Oh
    Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida
    Invest Ophthalmol Vis Sci 51:1651-8. 2010
    ..To evaluate photoreceptor inner/outer segment (IS/OS) defect parameters by using spectral domain-optical coherence tomography (SD-OCT) for correlation with visual outcomes in macular hole surgery (MHS)...
  14. doi Use of heavy Trypan blue in macular hole surgery
    S Y Lesnik Oberstein
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eye (Lond) 24:1177-81. 2010
    ..Heavy Trypan blue eliminates the need for an air-fluid exchange (AFX) and appears to have little retinal toxicity. This study refers to a prospective, consecutive trial with heavy Trypan blue in macular hole surgery...
  15. ncbi Retinal pigment epithelial tears after intravitreal bevacizumab injection for predominantly classic choroidal neovascularization
    L Arias
    Department of Ophthalmology, Bellvitge University Hospital, L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Ophthalmol 17:992-5. 2007
    ..To detect retinal pigment epithelium (RPE) tears in predominantly classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) treated with intravitreal bevacizumab injections...
  16. ncbi Macular hole surgery with and without indocyanine green assistance
    K Slaughter
    Ophthalmology Department, Royal Brisbane Hospital, Herston, Queensland, Australia
    Eye (Lond) 18:376-8. 2004
    ..To compare the results of macular hole surgery with the use of indocyanine green (ICG) to assist internal limiting membrane (ILM) peeling and macular hole surgery without indocyanine green use...
  17. doi Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial
    Noemi Lois
    Ophthalmology Department, Grampian University Hospitals NHS National Health Service Trust, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 52:1586-92. 2011
    ..To determine whether internal limiting membrane (ILM) peeling is effective and cost effective compared with no peeling in patients with idiopathic stage 2 or 3 full-thickness maculay hole (FTMH)...
  18. doi Microperimetric determination of retinal sensitivity in areas of dissociated optic nerve fiber layer following internal limiting membrane peeling
    Hiroki Imai
    Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan
    Jpn J Ophthalmol 54:435-40. 2010
    ..To investigate the effects of a dissociated optic nerve fiber layer (DONFL) on retinal sensitivity...
  19. doi Can the risk of retinal pigment epithelium tears after bevacizumab treatment be predicted? An optical coherence tomography study
    M Leitritz
    Department of Ophthalmology, University Eye Hospital, Tuebingen, Germany
    Eye (Lond) 22:1504-7. 2008
    ..The purpose of this study was to evaluate whether simple measurements of optical coherence tomography (OCT) can predict the individual risk of an RPE tear in preoperative candidates...
  20. ncbi Long-term follow-up after macular hole surgery with internal limiting membrane peeling
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Am J Ophthalmol 134:661-6. 2002
    ..To report long-term anatomical and functional results after pars plana vitrectomy with peeling of the internal limiting membrane (ILM) for idiopathic macular hole...
  21. doi The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study
    Ferdinando Bottoni
    Eye Clinic, Department of Clinical Science Luigi Sacco, Sacco Hospital, University of Milan, Milan, Italy
    Invest Ophthalmol Vis Sci 52:4439-46. 2011
    ..To analyze progressive changes of the outer retina after vitrectomy for macular hole (MH) repair...
  22. ncbi Improvements in the understanding and treatment of macular hole
    Mark W Johnson
    W K Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, Michigan 48105, USA
    Curr Opin Ophthalmol 13:152-60. 2002
    ....
  23. doi 25-Gauge sutureless vitrectomy versus 20-gauge vitrectomy for the repair of primary rhegmatogenous retinal detachment
    Manfred A Von Fricken
    Retina Group of Washington, Fairfax, Virginia, USA
    Retina 29:444-50. 2009
    ..To compare the anatomic and visual results and complications of 25-gauge transconjunctival sutureless vitrectomy versus conventional 20-gauge vitrectomy for the management of primary rhegmatogenous retinal detachment...
  24. doi Dyes in ocular surgery: principles for use in chromovitrectomy
    Michel Eid Farah
    Vision Institute, Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Ophthalmol 148:332-40. 2009
    ..To present the current state-of-the-art information regarding the properties, indications, surgical techniques, and toxic effects of current and past applications of vital dyes in chromovitrectomy...
  25. ncbi Internal limiting membrane peeling with indocyanine green or trypan blue in macular hole surgery: a randomized trial
    Julia Beutel
    University Eye Clinic, University Hospital Schleswig Holstein, Campus Lubeck, University at Lubeck, Lubeck, Germany
    Arch Ophthalmol 125:326-32. 2007
    ..To report on anatomical and visual outcomes after vitrectomy and internal limiting membrane peeling for idiopathic macular hole repair...
  26. ncbi Relationship of dissociated optic nerve fiber layer appearance to internal limiting membrane peeling
    Yoshinori Mitamura
    Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan
    Ophthalmology 112:1766-70. 2005
    ..We studied the relation between the DONFL appearance and internal limiting membrane (ILM) peeling and performed static microperimetry to explore the possible mechanisms underlying the DONFL appearance...
  27. doi Management of macular holes: a comparison of 1-year outcomes of 3 surgical techniques
    Shlomit Schaal
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
    Retina 29:1091-6. 2009
    ..To evaluate the contribution of internal limiting membrane (ILM) peeling with and without indocyanine green (ICG) to hole closure and functional results in patients with idiopathic macular hole...
  28. doi Retinal pigment epithelial tears in ranibizumab-treated eyes
    Bradley T Smith
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Retina 29:335-9. 2009
    ..To report the incidence of retinal pigment epithelial (RPE) tears in patients treated with ranibizumab therapy for choroidal neovascularization due to age-related macular degeneration...
  29. ncbi Internal limiting membrane peeling in macular hole surgery
    W E Smiddy
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida, USA
    Ophthalmology 108:1471-6; discussion 1477-8. 2001
    ..To evaluate prospectively the ability to peel epiretinal membranes and to correlate the degree of membrane peeling to anatomic success rates...
  30. doi Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes
    Louis K Chang
    Vitreous, Retina, Macula Consultants of New York, and the LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA
    Retina 28:969-75. 2008
    ..To examine the relationship between visual acuity and morphologic characteristics of macular holes as determined using spectral domain optical coherence tomography (SD OCT)...
  31. ncbi Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography
    Michael S Ip
    Department of Ophthalmology, University of Wisconsin, Clinical Science Center, F4 336, 600 Highland Ave, Madison, WI 53792, USA
    Arch Ophthalmol 120:29-35. 2002
    ....
  32. ncbi Traumatic macular hole: observations, pathogenesis, and results of vitrectomy surgery
    R N Johnson
    Retina Research Fund of St. Mary's Medical Center, San Francisco, California 94109, USA
    Ophthalmology 108:853-7. 2001
    ..The visual acuity improved two or more lines in 21 (84%) cases, and 16 (64%) achieved 20/50 or better vision. CONCLUSIONS: Vitrectomy surgery can successfully close macular holes associated with trauma and improve vision...
  33. doi 23-Gauge versus 20-gauge system for pars plana vitrectomy: a prospective randomised clinical trial
    B Wimpissinger
    Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Br J Ophthalmol 92:1483-7. 2008
    ..To compare the sutureless 23-gauge system with a standard 20-gauge system in pars plana vitrectomy...
  34. ncbi Macular hole formation: new data provided by optical coherence tomography
    A Gaudric
    Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris 7, France
    Arch Ophthalmol 117:744-51. 1999
    ..To establish the sequence of events leading from vitreofoveal traction to full-thickness macular hole formation...
  35. ncbi A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery
    Gildo Y Fujii
    Microsurgery Advanced Design Laboratory, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 109:1807-12; discussion 1813. 2002
    ..To introduce and evaluate the infusion and aspiration rates and operative times of the 25-gauge transconjunctival sutureless vitrectomy system (TSV) DESIGN: In vitro experimental and comparative interventional study...
  36. doi Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes
    S Kusuhara
    Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Hyogo, Japan
    Br J Ophthalmol 92:1261-4. 2008
    ..To assess the outcomes of 23-gauge sutureless transconjunctival vitrectomies (TSV), as compared with 25-gauge TSV in macular hole surgeries...
  37. doi Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections
    Clement K Chan
    Southern California Desert Retina Consultants, Palm Springs, California 92263, USA
    Retina 30:203-11. 2010
    ....
  38. ncbi Indocyanine green-assisted peeling of the retinal internal limiting membrane during vitrectomy surgery for macular hole repair
    A P Da Mata
    Cincinnati Eye Institute, Cincinnati, Ohio 45242, USA
    Ophthalmology 108:1187-92. 2001
    ..Indocyanine green staining of the ILM appears to be a safe and useful adjunct in vitreous surgery for macular hole repair...
  39. ncbi Macular hole in Behcet's disease
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 20:558-62. 2004
    ..In this report, we present two cases of macular hole in the worse eye of bilateral cases of Behcet's disease, and discuss the possible mechanisms and management in such cases...
  40. ncbi Outcome results in macular hole surgery: an evaluation of internal limiting membrane peeling with and without indocyanine green
    Tom G Sheidow
    Department of Ophthalmology, University of Western Ontario, London, Ontario, Canada
    Ophthalmology 110:1697-701. 2003
    ..To evaluate the anatomic closure rate and visual outcome in patients undergoing pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling with and without indocyanine green (ICG) enhancement...
  41. ncbi Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular holes
    Yasuki Ito
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Ophthalmology 112:1415-20. 2005
    ..To investigate the characteristics and incidence of a dissociated optic nerve fiber layer (DONFL) appearance in eyes after idiopathic macular hole surgery...
  42. pmc Types of macular hole closure and their clinical implications
    S W Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Br J Ophthalmol 87:1015-9. 2003
    ..To evaluate the clinical significance of macular hole closure types assessed by optical coherence tomography (OCT)...
  43. ncbi Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis
    J D Gass
    Department of Ophthalmology, Vanderbilt University, Nashville, Tenn 37232 8808, USA
    Arch Ophthalmol 117:821-3. 1999
    ....
  44. pmc Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body
    Hiroshi Izuta
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Mol Vis 16:130-6. 2010
    ..To investigate the relationships among antioxidant activities, oxidative stress, and vascular endothelial growth factor (VEGF) in the vitreous body and serum from proliferative diabetic retinopathy (PDR) patients...
  45. doi Prognostic significance of delayed structural recovery after macular hole surgery
    Ulrik C Christensen
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Ophthalmology 116:2430-6. 2009
    ..To assess the prognostic significance for visual function of persistent subfoveal fluid and persistent photoreceptor layer discontinuity in eyes in which hole closure had been obtained 3 months after macular hole surgery...
  46. doi Meta-analysis of chromovitrectomy with indocyanine green in macular hole surgery
    Eduardo B Rodrigues
    Department of Ophthalmology, Philipps University Marburg, Marburg, Germany
    Ophthalmologica 222:123-9. 2008
    ..To report a meta-analysis of the literature comparing internal limiting membrane (ILM) peeling with and without indocyanine green (ICG) staining in macular hole (MH) treatment...
  47. doi Comparative study between a standard 25-gauge vitrectomy system and a new ultrahigh-speed 25-gauge system with duty cycle control in the treatment of various vitreoretinal diseases
    Stanislao Rizzo
    Azienda Ospedaliera Universitaria Pisana, Eye Surgery Clinic, Pisa, Italy
    Retina 31:2007-13. 2011
    ..To compare a standard 25-gauge vitrectomy system with a new ultrahigh-speed (UHS) 25-gauge system with duty cycle control for pars plana vitrectomy...
  48. ncbi Effect on visual outcome after macular hole surgery when staining the internal limiting membrane with indocyanine green dye
    Naoichi Horio
    Department of Ophthalmology, Fujita Health University School of Medicine, Aichi, Japan
    Arch Ophthalmol 122:992-6. 2004
    ..To determine the effect on the visual outcome after macular hole surgery when staining the internal limiting membrane (ILM) with indocyanine green (ICG) dye and to study the mechanism of the adverse effects...
  49. ncbi Indocyanine green staining and removal of internal limiting membrane in macular hole surgery: histology and outcome
    Christos Haritoglou
    Am J Ophthalmol 133:587-8; author reply 588. 2002
  50. pmc The effect of internal limiting membrane removal and indocyanine green on the success of macular hole surgery
    John T Thompson
    Retina Specialists, Greater Baltimore Medical Center, Baltimore, Maryland, USA
    Trans Am Ophthalmol Soc 105:198-205; discussion 205-6. 2007
    ..To compare the anatomic and functional results of 3 different epimacular dissection techniques on macular hole surgery...
  51. ncbi Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular hole
    Masahiro Miura
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, 3 20 1 Chuo, Ami, Inashiki, Ibaraki 300 0395, Japan
    Retina 23:561-3. 2003
  52. doi Ultrastructure of the membrana limitans interna after dye-assisted membrane peeling
    Tobias Brockmann
    Department of Ophthalmology, Electron Microscopy Center, University Hospital Jena, Jena, Germany
    Ophthalmologica 226:228-33. 2011
    ..A possible explanation might be seen in the known photosensitivity of ICG, which induces a stiffening and shrinkage of the ILM but also generates retinal toxic metabolites...
  53. ncbi Spontaneous closure of traumatic macular hole
    Haruhiko Yamada
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan
    Am J Ophthalmol 134:340-7. 2002
    ..To investigate the mechanism by which traumatic macular hole closes spontaneously...
  54. ncbi Outcome of ICG-assisted ILM peel in macular hole surgery
    J Lochhead
    Oxford Eye Hospital, Radcliffe Infirmary, Woodstock Road, UK
    Eye (Lond) 18:804-8. 2004
    ..To investigate whether indocyanine green (ICG) staining of the internal limiting membrane (ILM) improves surgical outcome...
  55. ncbi Retinal pigment epithelial tear following intravitreal pegaptanib sodium
    Mandeep Singh Dhalla
    Barnes Retina Institute, St Louis, Missouri, USA
    Am J Ophthalmol 141:752-4. 2006
    ..To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium. To our knowledge, this is the first report of this finding after intraocular antivascular endothelial growth factor therapy...
  56. doi Optical coherence tomography predictive factors for macular hole surgery outcome
    J M Ruiz-Moreno
    Albacete Medical School, University of Castilla La Mancha, Albacete, Spain
    Br J Ophthalmol 92:640-4. 2008
    ..To evaluate the use of preoperative optical coherence tomography (OCT) findings as predictive factors for macular hole (MH) surgery outcomes...
  57. ncbi Pathogenesis of macular holes and therapeutic implications
    William E Smiddy
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33101, USA
    Am J Ophthalmol 137:525-37. 2004
    ..To review the literature and identify consistencies and inconsistencies in existing theories of pathogenesis and to consider some of their possible therapeutic implications...
  58. ncbi Histology of the vitreoretinal interface after staining of the internal limiting membrane using glucose 5% diluted indocyanine and infracyanine green
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Am J Ophthalmol 137:345-8. 2004
    ..To evaluate the effect of indocyanine green (ICG) diluted with glucose 5% on the human retina in an experimental setting in postmortem eyes and during surgery for macular hole formation...
  59. doi Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Ophthalmology 117:1815-24. 2010
    ..To evaluate reconstructive changes in foveal microstructures and identify a correlation with visual outcomes in eyes with surgically closed macular holes (MHs)...
  60. ncbi Spontaneous resolution of traumatic macular hole-related retinal detachment
    Michael M Lai
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Ophthalmol 141:1148-51. 2006
    ..To report a case of spontaneous resolution of traumatic macular hole-related retinal detachment...
  61. ncbi Indocyanine green for successful repair of a long-standing macular hole
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Am J Ophthalmol 136:389-91. 2003
    ..To report on the successful closure of a persistent chronic macular hole using indocyanine green (ICG) during the second surgical approach...
  62. ncbi [Optical coherence tomography of retinal pigment epithelial tears]
    C Torrón-Fernández-Blanco
    Servicio de Oftalmologia, Hospital Univrsitario Miguel Servet, Zaragoza, Espana
    Arch Soc Esp Oftalmol 82:245-9. 2007
    ..One of them was related to previous extrafoveal photocoagulation, whereas the other two were idiopathic. Fluorescein angiography (FA) and optical coherence tomography (OCT) were performed to confirm the clinical diagnosis...
  63. doi Comparative evaluation of anatomical and functional outcomes using brilliant blue G versus triamcinolone assisted ILM peeling in macular hole surgery in Indian population
    Atul Kumar
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    Graefes Arch Clin Exp Ophthalmol 249:987-95. 2011
    ..To compare anatomical and functional outcomes using brilliant blue G (BBG) vs triamcinolone acetonide (TA)-assisted ILM peeling in macular hole surgery (MHS)...
  64. ncbi Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy
    Eduardo B Rodrigues
    Retina Department, Hospital Regional Sao Jose, Instituto de Olhos Florianopolis, Centro Oftalmologico, Florianopolis, Brazil
    Retina 27:958-70. 2007
    ..The mechanisms of ICG-related toxicity and their relevance for chromovitrectomy are reviewed...
  65. ncbi Retinal pigment epithelium tears following ranibizumab for exudative age-related macular degeneration
    Petros E Carvounis
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 143:504-5. 2007
    ..To report two cases of retinal pigment epithelium (RPE) tears following intravitreous ranibizumab injection for age-related macular degeneration (AMD)-associated serous pigment epithelium detachment (PED)...
  66. pmc A comparison of outcomes after indocyanine green and trypan blue assisted internal limiting membrane peeling during macular hole surgery
    K L Lee
    Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand
    Br J Ophthalmol 89:420-4. 2005
    ..To compare the anatomical and visual outcomes of macular hole repair surgery using indocyanine green (ICG) or trypan blue (TB) staining of the internal limiting membrane (ILM)...
  67. doi Incidence of outer foveal defect after macular hole surgery
    Hiroki Kawano
    Department of Ophthalmology, Kagoshima City Hospital, Kagoshima, Japan
    Am J Ophthalmol 151:318-22. 2011
    ..To determine the incidence of outer foveal defects after macular hole surgery and to evaluate the relationship between the defect and visual outcome...
  68. ncbi Vitrectomy for chronic macular holes
    Lori A Stec
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan, USA
    Retina 24:341-7. 2004
    ..To address the efficacy of surgical intervention for chronic macular holes...
  69. ncbi Autologous platelets for macular hole surgery: the Sussex Eye Hospital experience
    Brendan J Vote
    Sussex Eye Hospital, Brighton, United Kingdom
    Clin Experiment Ophthalmol 32:472-7. 2004
    ..To evaluate the anatomical and visual outcomes of patients managed by macular hole surgery with adjunctive use of autologous platelets at Sussex Eye Hospital, UK...
  70. doi An in vivo evaluation of Brilliant Blue G in animals and humans
    M Remy
    Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr 8, 80336 Munich, Germany
    Br J Ophthalmol 92:1142-7. 2008
    ..To evaluate the retinal toxicity of Brilliant Blue G (BBG) following intravitreal injection in rat eyes and examine the biocompatibility and the staining properties in humans...
  71. ncbi Internal limiting membrane: ultrastructural relationships, with clinical implications for macular hole healing
    Flávio A Rezende
    Department of Ophthalmology, McGill University, Jewish General Hospital, Montreal, Que
    Can J Ophthalmol 39:251-9. 2004
    ....
  72. ncbi [A full thickness macular hole as an uncommon complication of Behçet disease]
    K Angioi-Duprez
    Service d ophtalmologie B, CHU Nancy Brabois
    J Fr Ophtalmol 24:172-4. 2001
    ..A review of the different ocular complications is provided, stressing the unusual location on the posterior segment and the potential seriousness of these complications...
  73. pmc Clinicopathological correlation of retinal pigment epithelial tears in exudative age related macular degeneration: pretear, tear, and scarred tear
    B A Lafaut
    University Eye Clinic, Joseph Stelzmann Strasse 9, D 50931 Cologne, Germany
    Br J Ophthalmol 85:454-60. 2001
    ..To analyse the histopathology of vascularised pigment epithelial detachments and tears of the retinal pigment epithelium (RPE) in age related macular degeneration (AMD)...
  74. ncbi What are vitreoretinal surgeons dyeing for?
    Anselm Kampik
    Retina 26:599-601. 2006
  75. ncbi Thinning and small holes at an impending tear of a retinal pigment epithelial detachment
    K Shiraki
    Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka, Japan
    Graefes Arch Clin Exp Ophthalmol 239:430-6. 2001
    ..A tear of a retinal pigment epithelial detachment (PED) suddenly exposes a large area of bare Bruch's membrane. We report here the case of a patient whom we observed during the gradual, spontaneous development of a PED tear...
  76. ncbi Retinal detachment due to a macular hole in a patient with Behcet disease treated with vitrectomy and silicone oil tamponade
    I Georgalas
    Department Ophthalmology, G Genimatas General Hospital of Athens, NHS, Athens Greece
    Eur J Ophthalmol 18:1023-4. 2008
    ..A rare case of unilateral retinal detachment due to a macular hole in a patient with Behçet disease is presented...
  77. ncbi Is it worth reoperating on macular holes?
    Xavier Valldeperas
    Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 115:158-63. 2008
    ..To evaluate the visual outcome after a second surgical attempt to close idiopathic full-thickness macular holes (FTMH) in patients who underwent unsuccessful primary surgery and in patients with reopened FTMHs...
  78. doi Vital dyes for macular surgery: a comparative electron microscopy study of the internal limiting membrane
    Ricarda G Schumann
    Department of Ophthalmology, Vitreoretinal and Pathology Unit, Ludwig Maximilians University, Munich, Germany
    Retina 29:669-76. 2009
    ..To analyze and compare the ultrastructure of the retinal cleavage plane of the internal limiting membrane (ILM) removed during dye-assisted macular surgery...
  79. pmc Retreatment of full-thickness macular hole: predictive value of optical coherence tomography
    Jost Hillenkamp
    Department of Ophthalmology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Br J Ophthalmol 91:1445-9. 2007
    ....
  80. ncbi Late reopening and spontaneous closure of previously repaired macular holes
    Jeffrey G Gross
    Carolina Retina Center, 7620 Trenholm Road Ext, Columbia, SC 29223, USA
    Am J Ophthalmol 140:556-8. 2005
    ..The features of late reopening with spontaneous closure in previously repaired macular holes are illustrated with optical coherence tomography (OCT)...
  81. pmc High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 113:2054.e1-14. 2006
    ..To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies...
  82. ncbi Retinal pigment epithelial tear following intravitreal injection of bevacizumab (Avastin)
    M Nicolo
    Department of Neuroscience, Ophthalmology and Genetics, University Eye Clinic and Ist Biosanitas, Genova, Italy
    Eur J Ophthalmol 16:770-3. 2006
    ..To report one case of retinal pigment epithelium tear following intravitreal bevacizumab injection for neovascular age-related macular degeneration...
  83. ncbi Retinal pigment epithelial tear after intravitreal bevacizumab injection
    Chirag P Shah
    Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 142:1070-2. 2006
    ..To report two cases of a retinal pigment epithelial (RPE) tear after intravitreal bevacizumab injection for exudative age-related macular degeneration (AMD)...
  84. ncbi Papillofoveal traction in macular hole formation: the role of optical coherence tomography
    D S Chauhan
    Department of Ophthalmology, United Medical Schools of Guy s and St Thomas, London, England
    Arch Ophthalmol 118:32-8. 2000
    ....
  85. ncbi Internal limiting membrane removal for traumatic macular holes
    F Kuhn
    Helen Keller Foundation, Birmingham, Alabama, USA
    Ophthalmic Surg Lasers 32:308-15. 2001
    ..To evaluate a new surgical technique for traumatic macular holes and to provide epidemiological information for such holes...
  86. ncbi Anatomical and visual outcomes of idiopathic macular hole surgery with internal limiting membrane removal using low-concentration indocyanine green
    Michael M Lai
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Retina 27:477-82. 2007
    ....
  87. ncbi Perifoveal vitreous detachment is the primary pathogenic event in idiopathic macular hole formation
    M W Johnson
    W K Kellogg Eye Center, 1000 Wall St, Ann Arbor, MI 48105, USA
    Arch Ophthalmol 119:215-22. 2001
    ..To evaluate the relationship between the posterior vitreous cortex and the posterior retina in eyes with early stages of idiopathic macular hole formation...
  88. ncbi Spontaneous reattachment of rhegmatogenous retinal detachment
    Hee Yoon Cho
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 114:581-6. 2007
    ..To describe the clinical characteristics of spontaneous reattachment of rhegmatogenous retinal detachment (SRRRD)...
  89. ncbi Diagnostic & therapeutic challenges. Tamoxifen toxicity
    Paul S Bernstein
    University of Utah, Department of Ophthalmology, John A Moran Eye Center, Salt Lake City, Utah, USA
    Retina 27:982-8. 2007
  90. ncbi Three-dimensional observations of developing macular holes
    S Kishi
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Am J Ophthalmol 130:65-75. 2000
    ..To describe the morphologic features of idiopathic macular holes and vitreous traction during macular hole evolution...
  91. ncbi Natural history of foveolar lucencies observed by optical coherence tomography after macular hole surgery
    Tamer H Mahmoud
    Department of Ophthalmology, Vitreoretinal Service, Duke University Eye Center, Durham, North Carolina, USA
    Retina 27:95-100. 2007
    ..To describe the incidence, course, and anatomic and functional outcomes of foveolar lucencies observed by optical coherence tomography after macular hole surgery...
  92. ncbi Triamcinolone acetonide remaining on the fovea after successful macular hole closure
    Mitsushi Fukukita
    Department of Ophthalmology, Mie University School of Medicine, Tsu Mie, Japan
    Retina 27:122-3. 2007
  93. ncbi Long-term functional outcome of macular hole surgery correlated to optical coherence tomography measurements
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Clin Experiment Ophthalmol 35:208-13. 2007
    ..Evaluation of long-term functional outcome after macular hole surgery and its correlation with postoperative optical coherence tomography (OCT)...
  94. ncbi Focal macular ERGs in eyes after removal of macular ILM during macular hole surgery
    H Terasaki
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Invest Ophthalmol Vis Sci 42:229-34. 2001
    ..In this study, the changes of each component of the focal macular electroretinograms (FMERGs) were investigated in eyes before and after the ILM was removed in the macular area during surgery for idiopathic macular holes (IMHs)...
  95. ncbi Long-term follow-up of high myopic foveoschisis: natural course and surgical outcome
    David Gaucher
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Service d Ophtalmologie Université Paris, France
    Am J Ophthalmol 143:455-62. 2007
    ..To determine the natural evolution and surgical indications of myopic foveoschisis (MF), which are still poorly documented, and the factors that predict poor prognosis...
  96. ncbi Residual crystals of triamcinolone acetonide in macular hole may prevent complete closure
    Takashi Koto
    Acta Ophthalmol Scand 85:913-4. 2007
  97. pmc Macular hole size as a prognostic factor in macular hole surgery
    S Ullrich
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Br J Ophthalmol 86:390-3. 2002
    ..The aim of this study was to evaluate the role of optical coherence tomography in diagnosing and staging, as well as in predicting, the functional and anatomical outcome after macular hole surgery...
  98. ncbi Development of macular pseudoholes: a 36-month period of follow-up
    Monica Varano
    Fondazione per l Oftalmologia G B Bietti, Rome, Italy
    Retina 22:435-42. 2002
    ..To assess the changes in visual acuity and macular sensitivity and the possible evolution into a full-thickness macular hole in patients with macular pseudoholes during a 3-year follow-up period...
  99. pmc Reorganization of photoreceptor layer on optical coherence tomography concurrent with visual improvement after macular hole surgery
    Ji Eun Lee
    Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea
    Korean J Ophthalmol 22:137-42. 2008
    ..The reorganization of the photoreceptor layer plays a part in long-term improvement of visual acuity after macular hole surgery...
  100. ncbi Optical coherence tomography--a review of the principles and contemporary uses in retinal investigation
    D Thomas
    St Thomas Hospital, Lambeth Palace Road, London, UK
    Eye (Lond) 18:561-70. 2004
  101. ncbi Indocyanine green-assisted internal limiting membrane peeling for macular holes to stain or not to stain?
    Andrea P Da Mata
    Retina 25:395-404. 2005

Research Grants20

  1. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2007
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  2. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2009
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  3. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2010
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  4. THE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYE
    Rajendra S Apte; Fiscal Year: 2010
    ..We aim to understand the mechanisms by which macrophage dysfunction promotes disease progression and hope to provide new insights in order to design future therapies to prevent blindness from these diseases. ..
  5. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2007
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  6. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2007
    ....
  7. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  8. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  9. Eye Disease in Cuban-American and Puerto Rican Adults
    Ingrid Scott; Fiscal Year: 2003
    ..g. NEI-VFQ 25) and eye service use. Subjects who refuse will be questioned as to reason(s) for refusal. ..
  10. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2006
    ..abstract_text> ..
  11. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..