open angle glaucoma

Summary

Summary: Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Top Publications

  1. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
  2. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
  3. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
  4. ncbi Primary open-angle glaucoma
    Robert N Weinreb
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
    Lancet 363:1711-20. 2004
  5. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
  6. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
  7. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
  8. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
  9. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
  10. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006

Detail Information

Publications319 found, 100 shown here

  1. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening...
  2. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
    ..To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020...
  3. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
    ..To assess factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of EMGT treatment...
  4. ncbi Primary open-angle glaucoma
    Robert N Weinreb
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
    Lancet 363:1711-20. 2004
    ..New treatments to directly treat and protect the retinal ganglion cells that are damaged in glaucoma are also in development...
  5. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..There is no consensus on the efficacy of medical treatment in delaying or preventing the onset of POAG in individuals with elevated IOP. Therefore, we designed a randomized clinical trial, the Ocular Hypertension Treatment Study...
  6. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
    ..To assess the prevalence and features of open-angle glaucoma in an urban population in southern India...
  7. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
    ..The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG...
  8. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
    ..Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG...
  9. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
    ....
  10. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006
    To contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells to that of control and primary open angle glaucoma (POAG) HTM tissues.
  11. ncbi Pattern of presentation and outcome of surgical management of primary open angle glaucoma in Kano, Northern Nigeria
    A Lawan
    Department of Ophthalmology, Faculty of Medicine, Bayero University Kano, Nigeria
    Ann Afr Med 6:180-5. 2007
    Primary open angle glaucoma (POAG) is one of the leading causes of avoidable blindness...
  12. ncbi Response of retinal vessel diameters to flicker stimulation in patients with early open angle glaucoma
    G Garhofer
    Department of Clinical Pharmacology, University of Vienna, Austria
    J Glaucoma 13:340-4. 2004
    ..The current study seeks to clarify whether flicker-induced vasodilatation of retinal vessels is diminished in glaucoma patients...
  13. pmc Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 49:5412-8. 2008
    ..To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma...
  14. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
    ..Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role...
  15. pmc Central retinal artery and vein collapse pressure in eyes with chronic open angle glaucoma
    J B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Br J Ophthalmol 87:949-51. 2003
    To determine central retinal vessel collapse pressure in chronic open angle glaucoma.
  16. ncbi Three and five year changes in intraocular pressures after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients
    Bradford J Shingleton
    Ophthalmic Consultants of Boston, Center for Eye Research and Education, Boston, MA, USA
    J Glaucoma 15:494-8. 2006
    ..the change in intraocular pressure (IOP) and glaucoma medication requirements after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients at 3 years and last follow-up (mean 5 y).
  17. ncbi Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens
    Stephanie C Joachim
    Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrabe 1, 55101 Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:573-80. 2008
    ..We analyzed the complex autoantibody patterns against human optic nerve antigens in sera of patients with glaucoma and tried to identify important antigens...
  18. ncbi Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial
    Anders Heijl
    Department of Ophthalmology, Malmo University Hospital, SE 20502 Malmo, Sweden
    Arch Ophthalmol 120:1268-79. 2002
    ..To provide the results of the Early Manifest Glaucoma Trial, which compared the effect of immediately lowering the intraocular pressure (IOP), vs no treatment or later treatment, on the progression of newly detected open-angle glaucoma...
  19. pmc Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
    Masakazu Nakano
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Proc Natl Acad Sci U S A 106:12838-42. 2009
    ..These findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis...
  20. ncbi Altered nitric oxide system in patients with open-angle glaucoma
    Kaija Polak
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Arch Ophthalmol 125:494-8. 2007
    ..To investigate the ocular blood flow response to systemic nitric oxide synthase inhibition in patients with primary open-angle glaucoma...
  21. ncbi Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, UK
    Exp Eye Res 90:750-7. 2010
    ..Such cascades of events initiated by ischemia to the optic nerve head region ultimately cause ganglion cells to die at different rates...
  22. ncbi Mitochondrial dysfunction and glaucoma
    George Y X Kong
    Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Australia
    J Glaucoma 18:93-100. 2009
    ..b>Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying ..
  23. ncbi Primary open-angle glaucoma in blacks: a review
    Lyne Racette
    Glaucoma Center and Visual Function Laboratory, Department of Ophthalmology, University of California at San Diego, La Jolla 92093 0946, USA
    Surv Ophthalmol 48:295-313. 2003
    ..Finally, they often have reduced accessibility to treatment and are less aware of the risks of having POAG. This article provides a comprehensive review of the current knowledge pertaining to POAG in blacks...
  24. ncbi Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 115:763-8. 2008
    ..To compare cerebrospinal fluid (CSF) pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients...
  25. pmc Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma
    M Emre
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box, 4012 Basel, Switzerland
    Br J Ophthalmol 89:60-3. 2005
    To compare the plasma levels of endothelin-1 (ET-1) between patients with primary open angle glaucoma with visual field progression despite normal or normalised intraocular pressure and patients with stabile visual fields in a ..
  26. pmc Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009
    ..These findings suggest a pathway in the pathophysiology of glaucoma through loss of neurotrophic function and may eventually open the possibility of using ligands activating TrkB to prevent the progression of the disease...
  27. ncbi Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography
    B C Chauhan
    Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 41:775-82. 2000
    ..To describe and evaluate a new statistical technique for detecting topographic changes in the optic disc and peripapillary retina measured with confocal scanning laser tomography...
  28. ncbi Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  29. ncbi Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States
    Franz H Grus
    Universitaets Augenklinik, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 47:968-76. 2006
    ..The purpose of this study was to compare the antibody profiles against optic nerve antigens in patients with glaucoma in two different study populations from Germany and the United States...
  30. ncbi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  31. ncbi Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery
    P R Lichter
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 108:1943-53. 2001
    ..Because 4 to 5 years of follow-up in a chronic disease is not adequate to draw treatment conclusions, these interim CIGTS outcomes do not support altering current treatment approaches to open-angle glaucoma...
  32. ncbi Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa
    P Challa
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27712, USA
    J Glaucoma 11:416-20. 2002
    ..Primary open-angle glaucoma patients with mutations in myocilin have a similar phenotype. Therefore, we investigated the role of mutations in myocilin in patients with POAG in a West African population...
  33. ncbi Temba glaucoma study: a population-based cross-sectional survey in urban South Africa
    Alan P Rotchford
    International Centre for Eye Health, The Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 110:376-82. 2003
    ..To determine the prevalence and features of glaucoma in an urban South African black population...
  34. ncbi Ocular response analyser to assess hysteresis and corneal resistance factor in low tension, open angle glaucoma and ocular hypertension
    Sunil Shah
    Heart of England Foundation Trust, Solihull, UK
    Clin Experiment Ophthalmol 36:508-13. 2008
    The aim of this study is to compare the hysteresis and corneal resistance factor (CRF) in normal tension glaucoma (NTG), primary open angle glaucoma (POAG) and ocular hypertension (OHT) eyes measured by the ocular response analyser (ORA).
  35. pmc Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma
    F Galassi
    Department of Oto Neuro Ophthalmological Sciences, University of Florence, Eye Unit II, Florence, Italy
    Br J Ophthalmol 88:757-60. 2004
    To investigate the levels of nitric oxide (NO) markers in plasma and aqueous humour of patients with primary open angle glaucoma (POAG) and their relation to ocular perfusion pressure.
  36. ncbi Prevalence of glaucoma in an African population
    C T Ntim-Amponsah
    University of Ghana, Medical School Accra, Ghana
    Eye (Lond) 18:491-7. 2004
    ..To determine the prevalence of primary open-angle glaucoma (POAG) in a Ghanaian population aged 30 years and above and to describe any ethnic variations in glaucoma prevalence in this population...
  37. ncbi Psychophysical investigation of ganglion cell loss in early glaucoma
    Paul G D Spry
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon, USA
    J Glaucoma 14:11-9. 2005
    ..To evaluate ganglion cell loss in early glaucoma using a variety of psychophysical tests and to identify optimal perimetric technique(s) for detection of early glaucomatous visual function loss...
  38. ncbi Sleep disorders: a risk factor for normal-tension glaucoma?
    D M Marcus
    Department of Ophthalmology, Medical College of Georgia, Augusta 30912, USA
    J Glaucoma 10:177-83. 2001
    ..To determine the prevalence of sleep-related symptoms and sleep-related breathing disorders by polysomnography in patients with normal-tension glaucoma (NTG)...
  39. ncbi [Use of YAG-Selecta laser and argon laser in the treatment of open angle glaucoma]
    G Popiela
    Katedry i Kliniki Okulistyki AM we Wrocławiu
    Klin Oczna 102:129-33. 2000
    ..The "selective" laser trabeculoplasty destroys melanosomes of pigmented trabecular meshwork cells, sparing adjacent non-pigmented cells and tissues...
  40. ncbi A comparison of the intervisit intraocular pressure fluctuation after 180 and 360 degrees of selective laser trabeculoplasty (SLT) as a primary therapy in primary open angle glaucoma and ocular hypertension
    Navin Prasad
    Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Glaucoma 18:157-60. 2009
    ....
  41. ncbi A randomized, crossover, open label pilot study to evaluate the efficacy and safety of Xalatan in comparison with generic Latanoprost (Latoprost) in subjects with primary open angle glaucoma or ocular hypertension
    Arun Narayanaswamy
    Medical Research Foundation, Sankara Nethralaya, Chennai, India
    Indian J Ophthalmol 55:127-31. 2007
    To compare the efficacy and tolerability of Xalatan with generic latanoprost (Latoprost) in subjects with primary open angle glaucoma (POAG) or ocular hypertension (OH).
  42. pmc Inherited, familial and sporadic primary open-angle glaucoma
    Gordon Gong
    West Texas EXPORT Center, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Science Center, Lubbock, TX 79409 USA
    J Natl Med Assoc 99:559-63. 2007
    ..We further formulated a mathematic model to estimate disease prevalence and mutation frequency taking both ethnic background and familial aggregation into consideration...
  43. pmc Association of IL1A and IL1B loci with primary open angle glaucoma
    Suddhasil Mookherjee
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, India
    BMC Med Genet 11:99. 2010
    ..It has been reported that polymorphisms in the IL1A and IL1B genes are associated with Primary Open Angle Glaucoma (POAG)...
  44. ncbi Mitochondrial abnormalities in patients with primary open-angle glaucoma
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory of the Genetics Department, King Fasail Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 47:2533-41. 2006
    ..The pathologic mechanism(s) of POAG remain unknown but may include retinal ganglion cell apoptosis, which causes progressive damage to axons at the optic nerve head...
  45. pmc Identification a novel MYOC gene mutation in a Chinese family with juvenile-onset open angle glaucoma
    Xin Zhao
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 16:1728-35. 2010
    To describe the clinical and genetic findings in one Chinese family with juvenile-onset open angle glaucoma (JOAG).
  46. pmc The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 14:518-22. 2008
    ..Glaucoma prevalence can vary geographically and ethnically, which suggests that a genetic element could play a significant role. Studies investigating the role of various mitochondrial haplogroups in the pathogenesis of glaucoma are scarce...
  47. pmc Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Mol Vis 13:12-7. 2007
    Oxidative DNA damage has been shown to have some role in the development of primary open angle glaucoma (POAG)...
  48. pmc Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, and Barbados Family Study Group, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:17105-10. 2009
    ..Our approach illustrates the merit of using an isolated population enriched with common disease variants as an efficient method to identify genetic underpinning of POAG...
  49. ncbi Glaucomatous optic neuropathy: mechanisms of disease
    D Lynn Halpern
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmol Clin North Am 15:61-8. 2002
    ..Until evidence from clinical trials demonstrates the effectiveness of these agents however, control of IOP will remain the mainstay of treatment for glaucoma...
  50. pmc Study of retinal nerve fibre layer thickness in eyes with high tension glaucoma and hemifield defect
    M S Kook
    Department of Ophthalmology, University of Ulsan, College of Medicine, Songpa Gu, Seoul, 138 736, Korea
    Br J Ophthalmol 85:1167-70. 2001
    ..To quantitatively evaluate retinal nerve fibre layer (RNFL) difference in areas of apparently normal appearing visual field in eyes with high tension glaucoma (HTG) and hemifield defects using scanning laser polarimetry...
  51. ncbi Comparative evaluation of bimatoprost monotherapy in primary chronic angle closure and primary open angle glaucoma eyes: a three-year study
    Viney Gupta
    Department of Ophthalmology, Glaucoma Research Facility and Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 23:351-8. 2007
    The aim of this study was to compare the long-term efficacy of bimatoprost 0.03% monotherapy in primary open angle glaucoma (POAG) versus primary chronic angle closure glaucoma (PCACG) eyes.
  52. ncbi Five-year risk of progression of ocular hypertension to primary open angle glaucoma. A population-based study
    Ravi Thomas
    L V Prasad Eye Institute, Vellore, India
    Indian J Ophthalmol 51:329-33. 2003
    To report the progression of ocular hypertension (OHT) to primary open angle glaucoma (POAG) during a 5-year follow up of a population-based sample.
  53. ncbi Prevalence of open-angle glaucoma in a rural south Indian population
    Lingam Vijaya
    Glaucoma Project, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Invest Ophthalmol Vis Sci 46:4461-7. 2005
    ..To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India...
  54. ncbi Oxidative stress markers in aqueous humor of glaucoma patients
    Sandra M Ferreira
    Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
    Am J Ophthalmol 137:62-9. 2004
    ..For this purpose the authors measured the total reactive antioxidant potential (TRAP) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase...
  55. ncbi Morphometric changes of the choriocapillaris and the choroidal vasculature in eyes with advanced glaucomatous changes
    Christoph W Spraul
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA
    Vision Res 42:923-32. 2002
    ..The purpose of this study was to quantify morphologic changes in the choroid including choriocapillaris thickness and density and diameter of large choroidal vessels in post mortem eyes with advanced primary open-angle glaucoma...
  56. pmc Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension
    W Y Zhang
    Centre for Evidence Based Pharmacotherapy, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Br J Ophthalmol 85:983-90. 2001
    ..To evaluate the comparative efficacy and tolerance of latanoprost versus timolol through a meta-analysis of randomised controlled trials (RCTs)...
  57. ncbi Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma
    Sergio Claudio Saccà
    Department of Neurosciences, Clinica Oculistica, University of Genoa, I 16132 Genoa, Italy
    Arch Ophthalmol 123:458-63. 2005
    ..To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration...
  58. pmc A randomised, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma
    M Nagar
    Department of Ophthalmology, St Thomas s Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Ophthalmol 89:1413-7. 2005
    ..005% for the control of intraocular pressure (IOP) in ocular hypertension (OHT) and open angle glaucoma (OAG).
  59. ncbi Vascular risk factors in glaucoma: the results of a national survey
    Nicola Orzalesi
    Department of Medicine, Surgery and Odontology, University of Milan, San Paolo Hospital, Milan, Italy
    Graefes Arch Clin Exp Ophthalmol 245:795-802. 2007
    ..To assess the importance of vascular risk factors in patients with primary open-angle glaucoma (POAG), data from the medical history of 2,879 POAG patients and 973 age-matched controls were collected and analyzed...
  60. ncbi Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension
    Gabriele Fuchsjager-Mayrl
    Departments of Clinical Pharmacology and Ophthalmology, and the Institute of Medical Physics, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 45:834-9. 2004
    ..In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and dorzolamide were compared...
  61. ncbi A possible link between the pseudoexfoliation syndrome and coronary artery disease
    M Citirik
    SB Ankara Eye Hospital, Turkey
    Eye (Lond) 21:11-5. 2007
    ..This is a collaborative case-control study from Ophthalmology and Cardiology departments of a tertiary care hospital, designed to explore the relationship between coronary artery disease (CAD) and pseudoexfoliation syndrome (PEX)...
  62. ncbi Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 88:776-85. 2009
    ....
  63. pmc Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study
    Christiane Wolf
    Centre for Ophthalmology, Institute for Ophthalmic Research, Molecular Genetics Laboratory, Tuebingen, Germany
    BMC Med Genet 10:91. 2009
    ..Instead, multigenic inheritance is proposed for the majority of cases. The present study tested common sequence variants in candidate genes for association with normal tension glaucoma in the German population...
  64. ncbi Profiling of WDR36 missense variants in German patients with glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:270-4. 2008
    ..In this study, the prevalence of WDR36 variants was investigated in patients with glaucoma who were of German descent with diverse age of onset and intraocular pressure levels...
  65. ncbi Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
    ....
  66. pmc A genome-wide scan maps a novel autosomal dominant juvenile-onset open-angle glaucoma locus to 2p15-16
    Ying Lin
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 14:739-44. 2008
    ..To study the clinical features and to perform genetic linkage study in two large Chinese families with autosomal dominant juvenile-onset primary open-angle glaucoma (POAG)...
  67. ncbi May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?
    Ozlem Yildirim
    Department of Ophthalmology, Mersin Üniversitesi Tıp Fakültesi, Mersin, Turkey
    Graefes Arch Clin Exp Ophthalmol 243:327-33. 2005
    ..To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma...
  68. ncbi Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma
    Oliver Arend
    Universitatsklinikum Aachen, Augenklinik der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Brain Res Bull 62:517-24. 2004
    To identify and quantify the role of retinal circulation, capillary leakage and/or nonperfusion of the optic nerve head in digital fluorescein angiography in normal subjects and patients with open angle glaucoma.
  69. ncbi Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1459-63. 2008
    ..In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent...
  70. ncbi Normal-tension glaucoma is associated with sleep apnea syndrome
    Daniel S Mojon
    Department of Neuro ophthalmology and Strabismus, Kantonsspital St Gallen, Switzerland
    Ophthalmologica 216:180-4. 2002
    ....
  71. ncbi Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study
    Kouros Nouri-Mahdavi
    Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles 90095, USA
    Ophthalmology 111:1627-35. 2004
    ..To investigate the risk factors associated with visual field (VF) progression in the Advanced Glaucoma Intervention Study (AGIS) with pointwise linear regression (PLR) analysis of serial VFs...
  72. ncbi Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes
    M Inatani
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Graefes Arch Clin Exp Ophthalmol 239:109-13. 2001
    ..0225) and the use of carbonic anhydrase inhibitors (P = 0.0143). CONCLUSIONS: Our results indicate that increased levels of TGF-beta 2 may play an important role in the pathogenesis of POAG...
  73. ncbi Myocilin analysis by DHPLC in French POAG patients: increased prevalence of Q368X mutation
    Rahma Melki
    INSERM U580, Hopital Necker, Paris, France
    Hum Mutat 22:179. 2003
    ..Based on these observations, a screening strategy of MYOC mutations in French POAG patients is briefly outlined...
  74. ncbi The s-cone PHNR and pattern ERG in primary open angle glaucoma
    N Drasdo
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, PO Box 905, Cardiff CF10 3YJ, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 42:1266-72. 2001
    ....
  75. ncbi Ocular pulse amplitude in normal tension and primary open angle glaucoma
    Ingeborg Stalmans
    Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
    J Glaucoma 17:403-7. 2008
    ..1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG)...
  76. ncbi Founder TIGR/myocilin mutations for glaucoma in the Québec population
    Mathieu Faucher
    Molecular Endocrinology and Oncology, Laval University Hospital CHUL Research Center, Quebec City, QC, Canada G1V 4G2
    Hum Mol Genet 11:2077-90. 2002
    ..Our data demonstrated that genetic screening for TIGR/MYOC mutations should be offered to glaucoma families and to close relatives of unrelated patients aware of a family history for the disorder...
  77. ncbi Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma
    Etsuko Shibuya
    Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 49:4453-7. 2008
    ..This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG...
  78. pmc Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Autophagy 5:122-4. 2009
    Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow ..
  79. ncbi Evaluation of Optineurin as a candidate gene in Indian patients with primary open angle glaucoma
    Arijit Mukhopadhyay
    Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata, India
    Mol Vis 11:792-7. 2005
    To evaluate the role of the optineurin gene (OPTN) in Indian primary open angle glaucoma (POAG) patients from different parts of the country.
  80. ncbi A review of the choice of therapy in primary open angle glaucoma
    A E Omoti
    Department of Ophthalmology, University of Benin Teaching Hospital, P M B 1111, Benin City
    Niger J Clin Pract 8:29-34. 2005
    ..There are now several potent modern drugs, which though expensive have acceptable safety profile, and fewer problems with compliance. The decision on the choice of therapy should be individualized and not be based on long-held beliefs...
  81. pmc Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 13:667-76. 2007
    ..This study was designed to evaluate the involvement of the CYP1B1, MYOC, OPTN, and OPTC genes in the etiology of adult-onset primary open-angle glaucoma (POAG) found in 251 Indian patients...
  82. pmc Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma
    Xiaobing Xie
    Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan, China
    Mol Vis 14:1666-72. 2008
    ..To investigate the genetic linkage of primary open-angle glaucoma (POAG) in a Chinese family...
  83. pmc Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields
    Pamela A Sample
    Visual Function, Department of Ophthalmology, University of California, La Jolla, 92093, USA
    Invest Ophthalmol Vis Sci 46:3684-92. 2005
    ..To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields...
  84. pmc Fine mapping of the GLC1K juvenile primary open-angle glaucoma locus and exclusion of candidate genes
    A Sud
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Mol Vis 14:1319-26. 2008
    ..The aim of this study is to refine the boundaries of the GLC1K region and to screen selected candidate genes located within the refined region for biologically significant mutations...
  85. ncbi Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1
    Karin Tosaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 51:417-23. 2007
    ..Heat-shock proteins (HSPs) or antibodies against them may contribute to glaucomatous optic neuropathy. We investigated the associations of HSP70-1 polymorphisms with open-angle glaucoma (OAG) in a Japanese population...
  86. ncbi Unilateral exfoliation syndrome: conversion to bilateral exfoliation and to glaucoma: a prospective 10-year follow-up study
    Päivi M Puska
    Helsinki University Eye Hospital, Helsinki, Finland
    J Glaucoma 11:517-24. 2002
    ..Risk factors for conversion to a bilateral condition and to glaucoma were studied...
  87. ncbi The uniocular drug trial and second-eye response to glaucoma medications
    Tony Realini
    Department of Ophthalmology, West Virginia University, Box 9193, Morgantown, WV 26505, USA
    Ophthalmology 111:421-6. 2004
    ..To determine if the intraocular pressure (IOP) reduction observed in a uniocular trial correlates with the IOP reduction seen in the fellow eye when the same medication is then administered to the second eye of patients with glaucoma...
  88. ncbi Relationship between retinal glial cell activation in glaucoma and vascular dysregulation
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 16:215-9. 2007
    ..To investigate the possible relationship between presumed activated retinal astrocytes and Müller cells (ARAM) and primary vascular dysregulation (PVD) in patients with primary open-angle glaucoma (POAG)...
  89. pmc The role of mitochondrial haplogroups in primary open angle glaucoma
    R Andrews
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Ophthalmol 90:488-90. 2006
    To investigate a possible association between mitochondrial haplogroups and primary open angle glaucoma (POAG).
  90. ncbi Glaucoma screening in a high-risk population
    Setareh Vistamehr
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    J Glaucoma 15:534-40. 2006
    To evaluate a screening protocol for detection of individuals with a higher risk of chronic open angle glaucoma for which a complete glaucoma evaluation is indicated.
  91. ncbi Cup-to-disc ratio, intraocular pressure, and primary open-angle glaucoma in retinal venous occlusion
    Paul E Beaumont
    Eye and Vision Research Institute, Sydney, Australia
    Ophthalmology 109:282-6. 2002
    ..To investigate the association of cup-to-disc ratio (CDR), intraocular pressure (IOP), and primary open-angle glaucoma (POAG) with the site of retinal venous occlusion (RVO) and optic nerve head swelling (ONHS)...
  92. pmc A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma
    G Rainer
    Department of Clinical Pharmacology, Institute of Medical Physics, Vienna, Austria
    Br J Clin Pharmacol 52:210-2. 2001
    AIMS: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. METHODS: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30)...
  93. ncbi Effects of systemic beta-blocker therapy on the efficacy and safety of topical brimonidine and timolol. Brimonidine Study Groups 1 and 2
    J S Schuman
    New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Ophthalmology 107:1171-7. 2000
    ....
  94. ncbi Intraocular pressure abnormalities associated with central and hemicentral retinal vein occlusion
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Ophthalmology 111:133-41. 2004
    ..To evaluate the prevalence of ocular hypertension (OHT) and glaucoma in patients with central retinal vein occlusion (CRVO) and hemi-CRVO (HCRVO) and of the fall in intraocular pressure (IOP) secondary to CRVO/HCRVO...
  95. ncbi Disease severity of familial glaucoma compared with sporadic glaucoma
    Johnny Wu
    Department of Ophthalmology, Royal Hobart Hospital, University of Tasmania, Hobart, Tasmania, Australia
    Arch Ophthalmol 124:950-4. 2006
    ..To determine whether there is a difference in disease severity between familial and sporadic primary open-angle glaucoma (POAG)...
  96. pmc Variation in optineurin (OPTN) allele frequencies between and within populations
    Rosa M Ayala-Lugo
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, MI, USA
    Mol Vis 13:151-63. 2007
    ..To evaluate the extent to which mutations in the optineurin (OPTN) glaucoma gene play a role in glaucoma in different populations...
  97. ncbi Presence of crystalline lens as a protective factor for the late development of open angle glaucoma after vitrectomy
    Fiona O J Luk
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, The People s Republic of China
    Retina 29:218-24. 2009
    To evaluate the late development of open angle glaucoma (OAG) after vitrectomy and to compare the rate of postvitrectomy OAG development in phakic and pseudophakic eyes.
  98. ncbi Intraocular pressure lowering efficacy and safety of travoprost 0.004% as a replacement therapy in patients with open angle glaucoma or ocular hypertension
    Jian Ge
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, Guangdong 510060, China
    Chin Med J (Engl) 123:1417-21. 2010
    ..The aim of this study was to evaluate the intraocular pressure (IOP) lowering efficacy of travoprost 0.004% monotherapy in patients previously treated with other topical hypotensive medications, and in previously untreated patients...
  99. pmc Primary open angle glaucoma. The need for a consensus case definition
    M Kroese
    Public Health Genetics Unit, Strangeways Research Laboratory, Cambridge, UK
    J Epidemiol Community Health 57:752-4. 2003
    Primary open angle glaucoma is an important cause of visual impairment and blindness in the United Kingdom. This paper gives a brief overview of the condition and its management...
  100. pmc Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension
    O Schwenn
    Augenklinik der Johannes Gutenberg Universität Mainz Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Br J Ophthalmol 86:981-4. 2002
    ..It was the aim of this study to evaluate OPA in patients with primary open angle glaucoma (POAG) and high IOP, normal tension glaucoma (NTG), and ocular hypertension (OHT)...
  101. ncbi Within-test variability of frequency-doubling perimetry using a 24-2 test pattern
    Paul G D Spry
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon, USA
    J Glaucoma 11:315-20. 2002
    ..To evaluate patient-response (within-test) variability for targets of the smaller frequency-doubling technology perimetry test that employs a 24-2 stimulus-presentation pattern...

Research Grants69

  1. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    Primary open angle glaucoma (POAG) is one of the four major causes of blindness and visual disability. Two million people in the United States have glaucoma; 100,000 of them are blind...
  2. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..Elevated intraocular pressure (IOP) is a prominent risk factor as seen in primary open angle glaucoma (POAG)...
  3. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..The purpose of this proposal is to examine how 3-synuclein affects prosurvival/prodeath signaling and how it is implicated in MMP-9 regulation in glaucoma. ..
  4. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..More broadly, this work serves as a foundation for a future line of investigations into sex-differences and non-hormonal mechanisms of optic nerve aging and risks for glaucoma. ..
  5. Forward Genetics to Identify Complex Gene Interactions Involved in Glaucoma
    Elena V Semina; Fiscal Year: 2010
    ..humans, we will identify complex genetic interactions that contribute to phenotypes associated with primary open angle glaucoma. The glaucomas are a group of vision impairing diseases characterized by retinal ganglion cell death, and ..
  6. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
    ..cells in the trabecular meshwork contribute to the pathogenesis of this tissue in aging and primary open angle glaucoma. The specific hypothesis to be tested is that down-regulation of the microRNAs miR-155, mir-204 and mir-29 ..
  7. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    ..It is likely that the viscoelastic properties and structure of human eyes with open angle glaucoma differ from those of normal eyes. These are in turn likely altered by the progression of glaucoma damage...
  8. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..Identifying distinct differences in vascular parameters between individuals of AD and ED will provide valuable insight into determining the mechanisms of disparity in glaucoma prevalence and progression in persons of AD. ..
  9. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..Our novel approach will provide important information about the pathophysiology of open angle glaucoma by identifying factors responsible for the loss of aqueous outflow facility...
  10. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..abstract_text> ..
  11. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2012
    ..These studies are focused at understanding the molecular nature of the aqueous humor outflow pathway, which is normally responsible for avoiding glaucoma and which becomes obstructed to produce glaucoma. ..
  12. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2013
    ..Furthermore, this research could lead to genotype-specific lifestyle modification strategies to prevent POAG...
  13. Mitochondrial dysfunction in glaucomatous optic neuropathy
    Won Kyu Ju; Fiscal Year: 2013
    ..of mitochondrial fusion-related optic atrophy 1 (OPA1) gene expression in patients with primary open angle glaucoma suggest that mitochondrial dysfunction is as an important pathophysiological mechanism, contributing to ..
  14. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary open angle glaucoma (POAG), the most common form of glaucoma, is usually accompanied by elevated intraocular pressure (IOP) due to failure of the trabecular meshwork (TM) to maintain normal ..
  15. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2013
    ..by applicant): Retinal ganglion cell (RGC) death is the primary cause of irreversible blindness in Open Angle Glaucoma (OAG) and most optic neuropathies...
  16. Genome-Wide Targeted Gene Resequencing in Glaucoma
    THERESA GAASTERLAND; Fiscal Year: 2010
    ..Primary open angle glaucoma (POAG) is the most frequent form of glaucoma in the United States and a leading cause of irreversible ..
  17. Open Angle Glaucoma in Soluble Guanylate Cyclase Alpha 1 Deficient Mice
    Emmanuel S Buys; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Open angle glaucoma (OAG) is a prevalent disease that results in irreversible loss of vision through the death of retinal ganglion cells (RGCs)...
  18. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  19. Extracelluar Matrix Organization and Biomechanics of the Lamina Cribrosa and Peri
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..There have been extensive studies concluding that primary open angle glaucoma (POAG) has a higher prevalence in populations of both African descent and Hispanic ethnicity...
  20. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013
    ..The results of this study will provide new insights for a novel therapeutic strategy to lower IOP by targeting the trabecular meshwork, where the initial problem resides. ..
  21. EVALUATION OF THE FREQUENCY OF VISUAL FIELD TESTING IN OCULAR HYPERTENSIVES
    Steven M Kymes; Fiscal Year: 2010
    ..treatment trial of the safety and efficacy of IOP lowering therapies for the prevention of primary open angle glaucoma (POAG)...
  22. African American Eye Disease Study
    Rohit Varma; Fiscal Year: 2013
    ..Specifically, AAs are believed to have higher rates of visual impairment, blindness, open angle glaucoma (OAG), diabetic retinopathy (DR) but lower rates of age-related macular degeneration (AMD) than Non-..
  23. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2012
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  24. MicroRNA-directed modulation of intraocular pressure
    Benjamin R tenOever; Fiscal Year: 2013
    ....
  25. High-resolution imaging of the normal and diseased retina
    Jason Porter; Fiscal Year: 2013
    ..e., laminar pore alteration) in glaucoma. ..
  26. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2013
    ..Although IOP is considered to be a primary risk factor for open angle glaucoma, the etiological mechanisms responsible for increased resistance to AH outflow are largely unknown...
  27. Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance
    Sayoko E Moroi; Fiscal Year: 2013
    ....
  28. Oxidative Stress and Lysosomal Function in the Outflow Pathway
    PALOMA LITON; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the conventional outflow pathway to maintain normal levels of aqueous humor (AH) ..
  29. Reverse Engineering of Trabecular Meshwork
    Nils A Loewen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): By the year 2020 the most common form of glaucoma, primary open angle glaucoma, will affect 59 million people causing bilateral blindness in 5.9 million...
  30. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2013
    ..meshwork (TM) and to eventually use this knowledge to develop effective therapies for preventing primary open angle glaucoma (POAG) progression...
  31. Improving Access to and Quality of Eye Care in an At-Risk, Underserved Population
    Cynthia Owsley; Fiscal Year: 2013
    ..Studies will focus on primary open angle glaucoma, diabetic eye care, and visually impaired persons in need of rehabilitation services...
  32. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2012
    ..Steroid-induced open angle glaucoma is caused by a decrease of trabecular meshwork (TM) outflow facility...
  33. Identification of quantitative ocular trait genes in the Beaver Dam Eye
    Alison P Klein; Fiscal Year: 2013
    ..Detection of genes that cause elevated intraocular pressure and refractive errors can be used to identify biological pathways that can be targeted with treatments to reduce the morbidity associated with these diseases. ..
  34. Glucocorticoids, ocular hypertension, and glaucoma
    Thomas Yorio; Fiscal Year: 2013
    ....
  35. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2013
    ..provided by applicant): The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  36. Mexican American Glaucoma Genetic Study (MAGGS)
    Xiaoyi Gao; Fiscal Year: 2013
    ..Primary open angle glaucoma (POAG) is the most common form of glaucoma and has a strong genetic component...
  37. Genes and Environment Initiative in Glaucoma
    Louis Pasquale; Fiscal Year: 2009
    ..Discovery of the various combinations of gene and environment interactions involved in POAG could lead to genotype-specific primary prevention strategies for this disease. ..
  38. sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
    Bruce R Ksander; Fiscal Year: 2012
    ..to establish sGCa1-/- mice as a novel, spontaneous and clinically relevant model for high IOP and primary open angle glaucoma (POAG) and to identify NO-cGMP signaling as a potential therapeutic target for elevated IOP and POAG...
  39. PREPROSTAGLANDIN ENDOPEROXIDES
    ROBERT GERD SALOMON; Fiscal Year: 2013
    ..of ethanolamine phospholipids and proteins by LGs/isoLGs accompanies the development of primary open angle glaucoma and AMD and contributes to pathology, and (2) that molecules that act as sacrificial nucleophiles can ..
  40. Restoration of Trabecular Meshwork by hMSC and Induced Pluripotent Stem Cells
    MARY JANE KELLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary open angle glaucoma is a major blinding disease, with elevated intraocular pressure (IOP) as a key risk factor...
  41. University of Miami Vision Loss Prevention Translational Research Center
    David J Lee; Fiscal Year: 2013
    ....
  42. Real time imaging of the aqueous outflow pathway by two-photon endoscopy
    Hiroshi Nakamura; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): It is well known that the elevated intraocular pressure of primary open angle glaucoma is related to an increased resistance to the outflow of aqueous humor...
  43. Identifying a Disease Gene Causing Primary Open Angle Glaucoma
    Rachel W Kuchtey; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Project Summary/Abstract In the United States, Primary Open Angle Glaucoma (POAG) is the second leading cause of blindness in the general population and the leading cause of blindness among African ..
  44. Improving Gaucoma Medication Adherence Through Education & Community Partnership
    KELLY MUIR; Fiscal Year: 2010
    ..Because open angle glaucoma is the leading cause of irreversible blindness worldwide and the leading cause of blindness in African ..
  45. xADAGES III: Contribution of genotype to glaucoma phenotype in African Americans
    Robert N Weinreb; Fiscal Year: 2013
    ..The most common form of glaucoma is primary open angle glaucoma (POAG)...
  46. LOS ANGELES LATINO EYE STUDY
    Rohit Varma; Fiscal Year: 2013
    ..abstract_text> ..
  47. A Previously Unrecognized Site of Resistance in POAG
    Haiyan Gong; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The source of abnormal outflow resistance in primary open angle glaucoma (POAG), a leading cause of blindness, has yet to be identified...
  48. Mechanisms of RGC Loss in a Murine Model of Glaucoma
    Frankie Lynn Silver; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Primary open angle glaucoma is a significant cause of vision loss in the United States, with a prevalence projected to exceed 3 million by 2020. Worldwide, close to 60 million will be affected...
  49. Unfolded Protein Response in Glaucoma Pathogenesis
    Markus H Kuehn; Fiscal Year: 2013
    ..myocilin (MYOC) are responsible for most cases of juvenile onset glaucoma and 3-4% of adult onset primary open angle glaucoma. A number of laboratories have presented data demonstrating that mutations in MYOC result in retention of ..
  50. Determining the role of WDR36 in adult-onset primary open-angle glaucoma
    Jonathan M Skarie; Fiscal Year: 2010
    ..Understanding the genes, such as WDR36, involved in the complex genetics of POAG will aid in the development of novel screening and treatment options for patients at risk or suffering from glaucoma. ..
  51. Structure and Biomechanics of the Human Optic Nerve Head
    Donald J Brown; Fiscal Year: 2013
    Primary open angle glaucoma (POAG) represents a serious and growing health problem accounting for ~12% of global blindness...
  52. SOLUTE TRANSPORT MECHANISMS IN THE CILIARY BODY
    Nicholas A Delamere; Fiscal Year: 2013
    ..Drugs that slow aqueous formation are a proven way to lower IOP in individuals that have primary open angle glaucoma. The number of persons with glaucoma is increasing and in the future there will be a growing need for novel,..
  53. Analysis of pathways and cells mediating optineurin glaucoma pathology
    JEREMIAH DANIEL PAULUS; Fiscal Year: 2013
    ..5% of primary open angle glaucoma cases for one population of glaucoma patients...
  54. The NEIGHBORHOOD: POAG Heritable Overall Operational Database
    Janey L Wiggs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary open angle glaucoma (POAG) is a significant cause of blindness worldwide. The etiology of POAG is poorly understood and primary prevention is not possible...
  55. Genetic dissection of pigment dispersing iris disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2012
    ..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..
  56. Molecular Genetics of Glaucoma
    Val C Sheffield; Fiscal Year: 2010
    DESCRIPTION: Primary open angle glaucoma (POAG) is a leading cause of blindness in developed countries...
  57. Identification of genes responsible for glucocorticoid-induced glaucoma
    Weiming Mao; Fiscal Year: 2013
    ..In addition, the knowledge of GIG will help us to understand primary open angle glaucoma because they share extensive similarities...
  58. Genomes in Eye Disease: Methods to Query Variants Across Multiple Genome-wide Dat
    THERESA GAASTERLAND; Fiscal Year: 2013
    ..We will use the tools to interrogate data relevant to the study of primary open angle glaucoma (POAG)...
  59. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    MICHAEL KASS; Fiscal Year: 2009
    ..I has shown that topical ocular hypotensive medication is safe and effective in reducing the incidence of open angle glaucoma in moderate and high risk ocular hypertensive patients, it is important to determine when treatment should ..
  60. FACTORS PREDICTIVE OF RAPID VISUAL FIELD LOSS IN EARLY GLAUCOMA
    Mae O Gordon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary open angle glaucoma (POAG) is a chronic progressive optic neuropathy and potentially blinding disease...
  61. Genetics of Adult-Onset POAG
    Mary K Wirtz; Fiscal Year: 2013
    ..by applicant): Glaucoma is a blinding disease affecting millions of people around the world;primary open angle glaucoma (POAG) is the most common form (70-90%)...
  62. Diagnostic Innovations in Glaucoma Study: Visual Function
    Felipe Medeiros; Fiscal Year: 2010
    ..Participants: At least 346 patients with primary open angle glaucoma, 209 at risk for vision loss due to the disease and 100 healthy age-matched controls...
  63. Genetic and Environmental Risk Factors for Exfoliation Syndrome and Glaucoma
    Janey L Wiggs; Fiscal Year: 2013
    ..Newly discovered genetic and environmental risk factors will be analyzed for gene- environment and gene-gene interactions. ..
  64. REGULATION OF TRABECULAR CELL GLYCOPROTEINS
    John Samples; Fiscal Year: 1991
    Primary open angle glaucoma is a common, insidious ophthalmic disorder characterized by an increased resistance to outflow of aqueous humor. Extracellular matrix (ECM) has been implicated as a major component of the barrier outflow...
  65. OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmology
    Linda Zangwill; Fiscal Year: 2009
    ..the European Glaucoma Prevention Study (EGPS), to improve our ability to predict the development of primary open angle glaucoma (POAG) in ocular hypertensive patients and to enhance our understanding of the effect of ocular hypotensive ..
  66. OCULAR ACTIONS OF ENDOTHELINS
    Thomas Yorio; Fiscal Year: 2005
    ..Recently, it has been shown that patients with primary open angle glaucoma (POAG) have an elevation in their aqueous humor endothelin (ET) concentrations...
  67. BARBADOS INCIDENCE STUDY OF EYE DISEASES II
    M Leske; Fiscal Year: 2001
    ..This information may assist to address major racial differences in prevalence and has important public health implications. ..
  68. QUALITY OF CHRONIC EYE CARE UNDER MANAGED CARE
    Jose Escarce; Fiscal Year: 2000
    ..The results of the project will inform policy debates about the merits of alternative ways to deliver care under managed care. ..
  69. PHOTOCHEMICAL TARGETING OF TRABECULAR MESHWORK CELLS
    Mark Latina; Fiscal Year: 1991
    The pathogenetic mechanism of progressive open angle glaucoma (POAG) is unproven. A significant decrease in the cellularity of the trabecular meshwork (TM) has been demonstrated in POAG specimens in comparison with age-matched normals...