open angle glaucoma

Summary

Summary: Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Top Publications

  1. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
  2. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
  3. doi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
  4. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
  5. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
  6. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
  7. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006
  8. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
  9. doi Mitochondrial dysfunction and glaucoma
    George Y X Kong
    Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Australia
    J Glaucoma 18:93-100. 2009
  10. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002

Detail Information

Publications287 found, 100 shown here

  1. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
    ..To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020...
  2. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
    ..To assess the prevalence and features of open-angle glaucoma in an urban population in southern India...
  3. doi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
    ..The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG...
  4. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
    ..Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG...
  5. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening...
  6. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..There is no consensus on the efficacy of medical treatment in delaying or preventing the onset of POAG in individuals with elevated IOP. Therefore, we designed a randomized clinical trial, the Ocular Hypertension Treatment Study...
  7. pmc Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Mol Vis 12:774-90. 2006
    To contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells to that of control and primary open angle glaucoma (POAG) HTM tissues.
  8. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
    ..Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role...
  9. doi Mitochondrial dysfunction and glaucoma
    George Y X Kong
    Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Australia
    J Glaucoma 18:93-100. 2009
    ..b>Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying ..
  10. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
    ....
  11. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
    ..To assess factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of EMGT treatment...
  12. ncbi Primary open-angle glaucoma
    Robert N Weinreb
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
    Lancet 363:1711-20. 2004
    ..New treatments to directly treat and protect the retinal ganglion cells that are damaged in glaucoma are also in development...
  13. ncbi Pattern of presentation and outcome of surgical management of primary open angle glaucoma in Kano, Northern Nigeria
    A Lawan
    Department of Ophthalmology, Faculty of Medicine, Bayero University Kano, Nigeria
    Ann Afr Med 6:180-5. 2007
    Primary open angle glaucoma (POAG) is one of the leading causes of avoidable blindness...
  14. doi Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, UK
    Exp Eye Res 90:750-7. 2010
    ..Such cascades of events initiated by ischemia to the optic nerve head region ultimately cause ganglion cells to die at different rates...
  15. doi Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 115:763-8. 2008
    ..To compare cerebrospinal fluid (CSF) pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients...
  16. ncbi Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States
    Franz H Grus
    Universitaets Augenklinik, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 47:968-76. 2006
    ..The purpose of this study was to compare the antibody profiles against optic nerve antigens in patients with glaucoma in two different study populations from Germany and the United States...
  17. ncbi Oxidative stress markers in aqueous humor of glaucoma patients
    Sandra M Ferreira
    Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
    Am J Ophthalmol 137:62-9. 2004
    ..For this purpose the authors measured the total reactive antioxidant potential (TRAP) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase...
  18. pmc Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma
    M Emre
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box, 4012 Basel, Switzerland
    Br J Ophthalmol 89:60-3. 2005
    To compare the plasma levels of endothelin-1 (ET-1) between patients with primary open angle glaucoma with visual field progression despite normal or normalised intraocular pressure and patients with stabile visual fields in a ..
  19. pmc Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009
    ..These findings suggest a pathway in the pathophysiology of glaucoma through loss of neurotrophic function and may eventually open the possibility of using ligands activating TrkB to prevent the progression of the disease...
  20. ncbi Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery
    P R Lichter
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 108:1943-53. 2001
    ..Because 4 to 5 years of follow-up in a chronic disease is not adequate to draw treatment conclusions, these interim CIGTS outcomes do not support altering current treatment approaches to open-angle glaucoma...
  21. doi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  22. ncbi Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa
    P Challa
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27712, USA
    J Glaucoma 11:416-20. 2002
    ..Primary open-angle glaucoma patients with mutations in myocilin have a similar phenotype. Therefore, we investigated the role of mutations in myocilin in patients with POAG in a West African population...
  23. ncbi Temba glaucoma study: a population-based cross-sectional survey in urban South Africa
    Alan P Rotchford
    International Centre for Eye Health, The Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 110:376-82. 2003
    ..To determine the prevalence and features of glaucoma in an urban South African black population...
  24. ncbi A randomized, crossover, open label pilot study to evaluate the efficacy and safety of Xalatan in comparison with generic Latanoprost (Latoprost) in subjects with primary open angle glaucoma or ocular hypertension
    Arun Narayanaswamy
    Medical Research Foundation, Sankara Nethralaya, Chennai, India
    Indian J Ophthalmol 55:127-31. 2007
    To compare the efficacy and tolerability of Xalatan with generic latanoprost (Latoprost) in subjects with primary open angle glaucoma (POAG) or ocular hypertension (OH).
  25. pmc Inherited, familial and sporadic primary open-angle glaucoma
    Gordon Gong
    West Texas EXPORT Center, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Science Center, Lubbock, TX 79409 USA
    J Natl Med Assoc 99:559-63. 2007
    ..We further formulated a mathematic model to estimate disease prevalence and mutation frequency taking both ethnic background and familial aggregation into consideration...
  26. pmc Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension
    O Schwenn
    Augenklinik der Johannes Gutenberg Universität Mainz Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Br J Ophthalmol 86:981-4. 2002
    ..It was the aim of this study to evaluate OPA in patients with primary open angle glaucoma (POAG) and high IOP, normal tension glaucoma (NTG), and ocular hypertension (OHT)...
  27. ncbi Three and five year changes in intraocular pressures after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients
    Bradford J Shingleton
    Ophthalmic Consultants of Boston, Center for Eye Research and Education, Boston, MA, USA
    J Glaucoma 15:494-8. 2006
    ..the change in intraocular pressure (IOP) and glaucoma medication requirements after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients at 3 years and last follow-up (mean 5 y).
  28. ncbi Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  29. ncbi Mitochondrial abnormalities in patients with primary open-angle glaucoma
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory of the Genetics Department, King Fasail Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 47:2533-41. 2006
    ..The pathologic mechanism(s) of POAG remain unknown but may include retinal ganglion cell apoptosis, which causes progressive damage to axons at the optic nerve head...
  30. doi A comparison of the intervisit intraocular pressure fluctuation after 180 and 360 degrees of selective laser trabeculoplasty (SLT) as a primary therapy in primary open angle glaucoma and ocular hypertension
    Navin Prasad
    Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Glaucoma 18:157-60. 2009
    ....
  31. pmc Association of IL1A and IL1B loci with primary open angle glaucoma
    Suddhasil Mookherjee
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, India
    BMC Med Genet 11:99. 2010
    ..It has been reported that polymorphisms in the IL1A and IL1B genes are associated with Primary Open Angle Glaucoma (POAG)...
  32. ncbi Glaucomatous optic neuropathy: mechanisms of disease
    D Lynn Halpern
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmol Clin North Am 15:61-8. 2002
    ..Until evidence from clinical trials demonstrates the effectiveness of these agents however, control of IOP will remain the mainstay of treatment for glaucoma...
  33. pmc Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
    Masakazu Nakano
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Proc Natl Acad Sci U S A 106:12838-42. 2009
    ..These findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis...
  34. pmc The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 14:518-22. 2008
    ..Glaucoma prevalence can vary geographically and ethnically, which suggests that a genetic element could play a significant role. Studies investigating the role of various mitochondrial haplogroups in the pathogenesis of glaucoma are scarce...
  35. ncbi Five-year risk of progression of ocular hypertension to primary open angle glaucoma. A population-based study
    Ravi Thomas
    L V Prasad Eye Institute, Vellore, India
    Indian J Ophthalmol 51:329-33. 2003
    To report the progression of ocular hypertension (OHT) to primary open angle glaucoma (POAG) during a 5-year follow up of a population-based sample.
  36. pmc Study of retinal nerve fibre layer thickness in eyes with high tension glaucoma and hemifield defect
    M S Kook
    Department of Ophthalmology, University of Ulsan, College of Medicine, Songpa Gu, Seoul, 138 736, Korea
    Br J Ophthalmol 85:1167-70. 2001
    ..To quantitatively evaluate retinal nerve fibre layer (RNFL) difference in areas of apparently normal appearing visual field in eyes with high tension glaucoma (HTG) and hemifield defects using scanning laser polarimetry...
  37. pmc Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, and Barbados Family Study Group, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:17105-10. 2009
    ..Our approach illustrates the merit of using an isolated population enriched with common disease variants as an efficient method to identify genetic underpinning of POAG...
  38. pmc Identification a novel MYOC gene mutation in a Chinese family with juvenile-onset open angle glaucoma
    Xin Zhao
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 16:1728-35. 2010
    To describe the clinical and genetic findings in one Chinese family with juvenile-onset open angle glaucoma (JOAG).
  39. ncbi Comparative evaluation of bimatoprost monotherapy in primary chronic angle closure and primary open angle glaucoma eyes: a three-year study
    Viney Gupta
    Department of Ophthalmology, Glaucoma Research Facility and Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 23:351-8. 2007
    The aim of this study was to compare the long-term efficacy of bimatoprost 0.03% monotherapy in primary open angle glaucoma (POAG) versus primary chronic angle closure glaucoma (PCACG) eyes.
  40. pmc Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Mol Vis 13:12-7. 2007
    Oxidative DNA damage has been shown to have some role in the development of primary open angle glaucoma (POAG)...
  41. ncbi Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma
    Sergio Claudio Saccà
    Department of Neurosciences, Clinica Oculistica, University of Genoa, I 16132 Genoa, Italy
    Arch Ophthalmol 123:458-63. 2005
    ..To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration...
  42. ncbi A possible link between the pseudoexfoliation syndrome and coronary artery disease
    M Citirik
    SB Ankara Eye Hospital, Turkey
    Eye (Lond) 21:11-5. 2007
    ..This is a collaborative case-control study from Ophthalmology and Cardiology departments of a tertiary care hospital, designed to explore the relationship between coronary artery disease (CAD) and pseudoexfoliation syndrome (PEX)...
  43. pmc Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study
    Christiane Wolf
    Centre for Ophthalmology, Institute for Ophthalmic Research, Molecular Genetics Laboratory, Tuebingen, Germany
    BMC Med Genet 10:91. 2009
    ..Instead, multigenic inheritance is proposed for the majority of cases. The present study tested common sequence variants in candidate genes for association with normal tension glaucoma in the German population...
  44. ncbi Vascular risk factors in glaucoma: the results of a national survey
    Nicola Orzalesi
    Department of Medicine, Surgery and Odontology, University of Milan, San Paolo Hospital, Milan, Italy
    Graefes Arch Clin Exp Ophthalmol 245:795-802. 2007
    ..To assess the importance of vascular risk factors in patients with primary open-angle glaucoma (POAG), data from the medical history of 2,879 POAG patients and 973 age-matched controls were collected and analyzed...
  45. ncbi Primary open-angle glaucoma in blacks: a review
    Lyne Racette
    Glaucoma Center and Visual Function Laboratory, Department of Ophthalmology, University of California at San Diego, La Jolla 92093 0946, USA
    Surv Ophthalmol 48:295-313. 2003
    ..Finally, they often have reduced accessibility to treatment and are less aware of the risks of having POAG. This article provides a comprehensive review of the current knowledge pertaining to POAG in blacks...
  46. ncbi Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension
    Gabriele Fuchsjager-Mayrl
    Departments of Clinical Pharmacology and Ophthalmology, and the Institute of Medical Physics, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 45:834-9. 2004
    ..In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and dorzolamide were compared...
  47. doi Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 88:776-85. 2009
    ....
  48. pmc A randomised, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma
    M Nagar
    Department of Ophthalmology, St Thomas s Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Ophthalmol 89:1413-7. 2005
    ..005% for the control of intraocular pressure (IOP) in ocular hypertension (OHT) and open angle glaucoma (OAG).
  49. ncbi Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
    ....
  50. pmc A genome-wide scan maps a novel autosomal dominant juvenile-onset open-angle glaucoma locus to 2p15-16
    Ying Lin
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 14:739-44. 2008
    ..To study the clinical features and to perform genetic linkage study in two large Chinese families with autosomal dominant juvenile-onset primary open-angle glaucoma (POAG)...
  51. doi Profiling of WDR36 missense variants in German patients with glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:270-4. 2008
    ..In this study, the prevalence of WDR36 variants was investigated in patients with glaucoma who were of German descent with diverse age of onset and intraocular pressure levels...
  52. pmc Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 13:667-76. 2007
    ..This study was designed to evaluate the involvement of the CYP1B1, MYOC, OPTN, and OPTC genes in the etiology of adult-onset primary open-angle glaucoma (POAG) found in 251 Indian patients...
  53. ncbi Evaluation of Optineurin as a candidate gene in Indian patients with primary open angle glaucoma
    Arijit Mukhopadhyay
    Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata, India
    Mol Vis 11:792-7. 2005
    To evaluate the role of the optineurin gene (OPTN) in Indian primary open angle glaucoma (POAG) patients from different parts of the country.
  54. pmc Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 49:5412-8. 2008
    ..To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma...
  55. doi Ocular pulse amplitude in normal tension and primary open angle glaucoma
    Ingeborg Stalmans
    Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
    J Glaucoma 17:403-7. 2008
    ..1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG)...
  56. ncbi Myocilin analysis by DHPLC in French POAG patients: increased prevalence of Q368X mutation
    Rahma Melki
    INSERM U580, Hopital Necker, Paris, France
    Hum Mutat 22:179. 2003
    ..Based on these observations, a screening strategy of MYOC mutations in French POAG patients is briefly outlined...
  57. ncbi The s-cone PHNR and pattern ERG in primary open angle glaucoma
    N Drasdo
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, PO Box 905, Cardiff CF10 3YJ, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 42:1266-72. 2001
    ....
  58. ncbi A review of the choice of therapy in primary open angle glaucoma
    A E Omoti
    Department of Ophthalmology, University of Benin Teaching Hospital, P M B 1111, Benin City
    Niger J Clin Pract 8:29-34. 2005
    ..There are now several potent modern drugs, which though expensive have acceptable safety profile, and fewer problems with compliance. The decision on the choice of therapy should be individualized and not be based on long-held beliefs...
  59. doi Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma
    Etsuko Shibuya
    Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 49:4453-7. 2008
    ..This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG...
  60. pmc Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Autophagy 5:122-4. 2009
    Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow ..
  61. ncbi Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes
    M Inatani
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Graefes Arch Clin Exp Ophthalmol 239:109-13. 2001
    ..0225) and the use of carbonic anhydrase inhibitors (P = 0.0143). CONCLUSIONS: Our results indicate that increased levels of TGF-beta 2 may play an important role in the pathogenesis of POAG...
  62. ncbi Founder TIGR/myocilin mutations for glaucoma in the Québec population
    Mathieu Faucher
    Molecular Endocrinology and Oncology, Laval University Hospital CHUL Research Center, Quebec City, QC, Canada G1V 4G2
    Hum Mol Genet 11:2077-90. 2002
    ..Our data demonstrated that genetic screening for TIGR/MYOC mutations should be offered to glaucoma families and to close relatives of unrelated patients aware of a family history for the disorder...
  63. pmc Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma
    Xiaobing Xie
    Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan, China
    Mol Vis 14:1666-72. 2008
    ..To investigate the genetic linkage of primary open-angle glaucoma (POAG) in a Chinese family...
  64. ncbi Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1
    Karin Tosaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 51:417-23. 2007
    ..Heat-shock proteins (HSPs) or antibodies against them may contribute to glaucomatous optic neuropathy. We investigated the associations of HSP70-1 polymorphisms with open-angle glaucoma (OAG) in a Japanese population...
  65. pmc Fine mapping of the GLC1K juvenile primary open-angle glaucoma locus and exclusion of candidate genes
    A Sud
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Mol Vis 14:1319-26. 2008
    ..The aim of this study is to refine the boundaries of the GLC1K region and to screen selected candidate genes located within the refined region for biologically significant mutations...
  66. pmc Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields
    Pamela A Sample
    Visual Function, Department of Ophthalmology, University of California, La Jolla, 92093, USA
    Invest Ophthalmol Vis Sci 46:3684-92. 2005
    ..To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields...
  67. pmc Central retinal artery and vein collapse pressure in eyes with chronic open angle glaucoma
    J B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Br J Ophthalmol 87:949-51. 2003
    To determine central retinal vessel collapse pressure in chronic open angle glaucoma.
  68. ncbi Mini-trabeculectomy in comparison to conventional trabeculectomy in primary open angle glaucoma
    S K Thimmarayan
    Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    Eur J Ophthalmol 16:674-9. 2006
    To evaluate the safety and efficacy of mini-trabeculectomy in comparison to conventional trabeculectomy in primary open angle glaucoma (POAG).
  69. ncbi Glaucoma following congenital cataract surgery: an 18-year longitudinal follow-up
    G Magnusson
    Department of Ophthalmology, Goteborg University, Sweden
    Acta Ophthalmol Scand 78:65-70. 2000
    ..To report the occurrence of postoperative glaucoma and to evaluate risk factors...
  70. ncbi Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial
    Anders Heijl
    Department of Ophthalmology, Malmo University Hospital, SE 20502 Malmo, Sweden
    Arch Ophthalmol 120:1268-79. 2002
    ..To provide the results of the Early Manifest Glaucoma Trial, which compared the effect of immediately lowering the intraocular pressure (IOP), vs no treatment or later treatment, on the progression of newly detected open-angle glaucoma...
  71. ncbi [Prevalance of open angle glaucoma and ocular hypertension as a risk factor for primary open angle glaucoma in Wroclaw population. Wroclaw Epidemiology Study]
    Maria Hanna Nizankowska
    Kliniki Okulistyki Akademii Medycznej we Wrocławiu
    Klin Oczna 106:147-52. 2004
    The purpose of the study is to assess the prevalence of various types of open angle glaucoma (OAG) and ocular hypertension (OH) as a risk factor for AOG...
  72. doi Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma
    Ping Huang
    Peking University Eye Center, Peking University Third Hospital, Peking University, Beijing, China
    J Glaucoma 19:324-30. 2010
    ..The purpose of this study is to compare human serum levels of TH1 and TH2 cytokines between 2 stages of primary open-angle glaucoma (POAG) and nonglaucomatous controls...
  73. doi Long-term results of viscocanalostomy in pseudoexfoliative and primary open angle glaucoma
    Peter K Wishart
    St Paul s Eye Unit, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 36:148-55. 2008
    To document the outcome of viscocanalostomy (VC) alone or combined with phacoemulsification (phaco-VC) in eyes with pseudoexfoliation glaucoma (PEXG) and primary open angle glaucoma (POAG).
  74. doi [Measurement of viscoelastic corneal parameters (corneal hysteresis) in patients with primary open angle glaucoma]
    B Schroeder
    Augenabteilung, Asklepios Klinik Nord Heidberg, Tangstedter Landstrasse 400, 22413, Hamburg, Germany
    Ophthalmologe 105:916-20. 2008
    ..Corneal hysteresis (CH) is defined as the difference in intraocular pressure recorded during inward and outward applanation. CH is therefore an indicator for the viscoelastic properties of the cornea...
  75. doi Atypical retinitis pigmentosa masquerading as primary open angle glaucoma
    Sophia L Dauber
    J Glaucoma 17:248; author reply 248-9. 2008
  76. ncbi The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study
    R Altan-Yaycioglu
    Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Turkey
    Eur J Ophthalmol 11:37-46. 2001
    To evaluate the effects of four commonly used beta-blockers on ocular blood flow in patients with primary open angle glaucoma (POAG).
  77. ncbi Potential diagnostic value of fluorescein angiography and color Doppler imaging in primary open angle glaucoma
    Tharwat H Mokbel
    Ophthalmology Center, Faculty of Medicine, Mansoura University, Mansoura Egypt
    Eur J Ophthalmol 19:957-62. 2009
    To evaluate absolute filling defects of the optic disc and color Doppler imaging (CDI) measurements in primary open angle glaucoma (POAG) to assess their diagnostic potentialities.
  78. doi A comparison among Humphrey field analyzer, Microperimetry, and Heidelberg Retina Tomograph in the evaluation of macula in primary open angle glaucoma
    Faruk Ozturk
    Faculty of Medicine, Department of Ophthalmology, Afyon Kocatepe University, Afyonkarahisar, Turkey
    J Glaucoma 17:118-21. 2008
    ..In this study, we aimed to evaluate the functional and morphologic changes of macula in patients having glaucoma using Microperimeter-1 (MP-1), Humphrey field analyzer (HFA), and Heidelberg Retina Tomograph II (HRT-II)...
  79. doi Feline primary open angle glaucoma
    Susan Jacobi
    Department of Small Animal Clinical Sciences, Veterinary Teaching Hospital, Michigan State University, East Lansing, MI, USA
    Vet Ophthalmol 11:162-5. 2008
    We have documented the histomorphological features of feline primary open angle glaucoma.
  80. pmc A 7 year prospective comparative study of three topical beta blockers in the management of primary open angle glaucoma
    P G Watson
    University of Leiden, Netherlands
    Br J Ophthalmol 85:962-8. 2001
    ..To determine the long term efficacy of monotherapy with topically applied beta blocking agents and to determine whether selective beta blockers were able to preserve the visual field more effectively than non-selective agents...
  81. ncbi Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma
    F S Weinand
    Department of Ophthalmology, University Eye Clinic, Giessen, Germany
    Eur J Ophthalmol 16:100-4. 2006
    ..To investigate the long-term efficacy of selective laser trabeculoplasty (SLT) in primary open-angle glaucoma, the authors performed a non-randomized, prospective, non-comparative clinical case series...
  82. ncbi Glaucomatous outflow pathway and oxidative stress
    Sergio Claudio Saccà
    San Martino Hospital, Section of Ophthalmology, Largo Rosanna Benzi 1, 16132 Genova, Italy
    Exp Eye Res 84:389-99. 2007
    ..On the whole, these findings support the hypothesis that oxidative damage is an important step in the pathogenesis of primary open-angle glaucoma, and might be a relevant target for both prevention and therapy...
  83. doi Screening for open angle glaucoma: systematic review of cost-effectiveness studies
    Rodolfo Hernandez
    Health Economics Research Unit, University of Aberdeen, Aberdeen, Scotland, UK
    J Glaucoma 17:159-68. 2008
    To systematically review current evidence on the cost-effectiveness of screening strategies for open angle glaucoma (OAG).
  84. ncbi Causal inference in primary open angle glaucoma: specific discussion on intraocular pressure
    Hossein Bahrami
    Department of Ophthalmology, Johns Hopkins Schools of Medicine and Public Health, Johns Hopkins University, Baltimore, MD, USA
    Ophthalmic Epidemiol 13:283-9. 2006
    ..how causal inference is established in epidemiology and applies these methods to evaluate the evidence in favor or against the causal association between intraocular pressure (IOP) and primary open angle glaucoma (POAG) as an example.
  85. pmc Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism
    Christopher L Daugherty
    Department of Ophthalmology, West Virginia University, Morgantown, WV 26506, USA
    Mol Vis 15:1939-44. 2009
    ..The goal of this study was to examine the role of this polymorphism in susceptibility to POAG in a Caucasian population from the United States...
  86. ncbi Primary open angle glaucoma was not found to be associated with p53 codon 72 polymorphism in a Brazilian cohort
    R E Silva
    Pronto Clínica de Olhos, Goiania, GO, Brazil
    Genet Mol Res 8:268-72. 2009
    Primary open angle glaucoma (POAG) is the most common type of glaucoma...
  87. doi Cigarette smoking and primary open angle glaucoma: a systematic review
    Richard Edwards
    Department of Public Health, University of Otago, Wellington, New Zealand
    J Glaucoma 17:558-66. 2008
    To evaluate the epidemiologic evidence for a causal association between tobacco smoking and primary open angle glaucoma (POAG).
  88. doi Glaucoma-associated WDR36 variants encode functional defects in a yeast model system
    Tim K Footz
    Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada
    Hum Mol Genet 18:1276-87. 2009
    ..These results demonstrate that, in the correct genetic background, WDR36 sequence variants can lead to an altered cellular phenotype, supporting the theory that WDR36 participates in polygenic forms of glaucoma...
  89. pmc Longitudinal glaucoma screening for siblings of patients with primary open angle glaucoma: the Nottingham Family Glaucoma Screening Study
    V C T Sung
    Eye, Ear, Nose and Throat Centre, Queen s Medical Centre University Hospital NHS Trust, Nottingham NG7 2UH, UK
    Br J Ophthalmol 90:59-63. 2006
    To assess the prevalence and cumulative incidence of open angle glaucoma (OAG) in a cohort group of siblings of OAG probands.
  90. pmc Prevalence of primary open angle glaucoma in general ophthalmic practice in the United Kingdom
    M Kroese
    Eastern Region Public Health Observatory, Institute of Public Health, Box 113, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Br J Ophthalmol 86:978-80. 2002
    To estimate the predicted prevalence of primary open angle glaucoma (POAG) from the activity of a local ophthalmology department.
  91. ncbi Analysis of risk factors that may be associated with progression from ocular hypertension to primary open angle glaucoma
    John Landers
    Eye Associates, Sydney University, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 30:242-7. 2002
    ..Ocular hypertension (OHT) may develop into primary open angle glaucoma (POAG) for many patients...
  92. ncbi Detection of early visual field loss in glaucoma using frequency-doubling perimetry and short-wavelength automated perimetry
    John A Landers
    Eye Associates and Save Sight Institute, Sydney University, Sydney, New South Wales, Australia
    Arch Ophthalmol 121:1705-10. 2003
    ..To investigate whether frequency-doubling perimetry (FDP) predicts future visual field loss with achromatic automated perimetry (AAP), just as it may be predicted with short-wavelength automated perimetry (SWAP)...
  93. ncbi Long-term evaluation of trabeculectomy in primary open angle glaucoma and chronic primary angle closure glaucoma in an Asian population
    Ramanjit Sihota
    Dr Rajendra Prasad Centre of Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Clin Experiment Ophthalmol 32:23-8. 2004
    A retrospective cohort study was undertaken to evaluate and compare the long-term results of trabeculectomy in primary open angle glaucoma (POAG) and chronic primary angle closure glaucoma (CPACG) in an Asian population.
  94. pmc Novel LMX1B mutation in familial nail-patella syndrome with variable expression of open angle glaucoma
    Elena Milla
    Departamento de Oftalmologia, Hospital Clinic de Barcelona, Barcelona, Spain
    Mol Vis 13:639-48. 2007
    To describe the genetic and clinical findings in a large Spanish pedigree with nail-patella syndrome (NPS) and to investigate the expressivity of open angle glaucoma (OAG) in the family members.
  95. ncbi A comparison of the circadian rhythm of intraocular pressure in primary phronic angle closure glaucoma, primary open angle glaucoma and normal eyes
    Ramanjit Sihota
    Dr Rajendra Prasad Centre for Ophthalmic Science, All India Institute of Medical Science, New Delhi
    Indian J Ophthalmol 53:243-7. 2005
    To evaluate the circadian rhythm of intraocular pressure (IOP) in primary chronic angle closure glaucoma (PCACG), primary open angle glaucoma (POAG), and normal eyes.
  96. pmc Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population
    Fumihiko Mabuchi
    Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Mol Vis 15:1045-9. 2009
    To assess whether tumor protein p53 gene (p53) polymorphisms are associated with primary open angle glaucoma (POAG) in the Japanese population.
  97. ncbi Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma
    Fuu Jen Tsai
    Department of Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 17:259-63. 2003
    ..In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital...
  98. ncbi Targeting relatives of patients with primary open angle glaucoma: the help the family glaucoma project
    Constance Nduaguba Okeke
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Glaucoma 16:549-55. 2007
    To assess the knowledge of patients with open angle glaucoma (OAG) and their family members about OAG risk factors and to study the referral of family members for eye examinations.
  99. ncbi The role of diurnal pressure measurements in the management of open angle glaucoma
    Jacob T Wilensky
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
    Curr Opin Ophthalmol 15:90-2. 2004
    ..This review will analyze recent articles that report the impact of various glaucoma therapies on the diurnal IOP curve and the use of diurnal curves in glaucoma diagnosis...
  100. ncbi Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma
    Oliver Arend
    Universitatsklinikum Aachen, Augenklinik der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Brain Res Bull 62:517-24. 2004
    To identify and quantify the role of retinal circulation, capillary leakage and/or nonperfusion of the optic nerve head in digital fluorescein angiography in normal subjects and patients with open angle glaucoma.
  101. pmc Rapid mutation detection by the transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma
    C J Cobb
    Department of Ophthalmology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Ophthalmol 86:191-5. 2002
    To rapidly screen Scottish patients with a family history of open angle glaucoma (OAG) or ocular hypertension (OHT) for mutations in the myocilin gene (MYOC) and develop a new rapid screening method for MYOC mutation detection.

Research Grants75

  1. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    Primary open angle glaucoma (POAG) is one of the four major causes of blindness and visual disability. Two million people in the United States have glaucoma; 100,000 of them are blind...
  2. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2010
    ..Elevated intraocular pressure (IOP) is a prominent risk factor as seen in primary open angle glaucoma (POAG)...
  3. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1993
    ..Since primary open angle glaucoma (POAG) is known to be an age- related disorder, specimens obtained from donors of three different age ..
  4. Structure and Biomechanics of the Human Optic Nerve Head
    Donald J Brown; Fiscal Year: 2010
    Primary open angle glaucoma (POAG) represents a serious and growing health problem accounting for ~12% of global blindness...
  5. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2010
    ..These studies are focused at understanding the molecular nature of the aqueous humor outflow pathway, which is normally responsible for avoiding glaucoma and which becomes obstructed to produce glaucoma. ..
  6. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted Acott; Fiscal Year: 2009
    ..These studies are focused at understanding the molecular nature of the aqueous humor outflow pathway, which is normally responsible for avoiding glaucoma and which becomes obstructed to produce glaucoma. ..
  7. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2010
    ..Steroid-induced open angle glaucoma is caused by a decrease of trabecular meshwork (TM) outflow facility...
  8. Admixture Mapping of Glaucoma Genes in African Americans
    Michael Hauser; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  9. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2010
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  10. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2010
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  11. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    ROBERT WORDINGER; Fiscal Year: 2009
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  12. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    ROBERT WORDINGER; Fiscal Year: 2009
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  13. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2009
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  14. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  15. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  16. GLAUCOMA-CONNECTIVE TISSUE CHANGES IN OPTIC NERVE HEAD
    M Rosario Hernandez; Fiscal Year: 2007
    Our long-term objective is to determine how astrocytes contribute to optic neuropathy in primary open angle glaucoma (POAG)...
  17. OCULAR ACTIONS OF ENDOTHELINS
    Thomas Yorio; Fiscal Year: 2005
    ..Recently, it has been shown that patients with primary open angle glaucoma (POAG) have an elevation in their aqueous humor endothelin (ET) concentrations...
  18. Glucocorticoids, Ocular Hypertension and Glaucoma
    Thomas Yorio; Fiscal Year: 2009
    ..These specific aims are designed to determine if GRbeta regulates GC responsiveness and if decreases in its expression contribute to ocular hypertension often seen in patients with POAG. ..