open angle glaucoma

Summary

Summary: Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Top Publications

  1. ncbi The association between glaucomatous visual fields and optic nerve head features in the Ocular Hypertension Treatment Study
    John L Keltner
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1603-12. 2006
  2. ncbi The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
  3. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
  4. ncbi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
  5. ncbi Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, UK
    Exp Eye Res 90:750-7. 2010
  6. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
  7. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
  8. ncbi Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009
  9. ncbi The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 14:518-22. 2008
  10. ncbi Study of retinal nerve fibre layer thickness in eyes with high tension glaucoma and hemifield defect
    M S Kook
    Department of Ophthalmology, University of Ulsan, College of Medicine, Songpa Gu, Seoul, 138 736, Korea
    Br J Ophthalmol 85:1167-70. 2001

Research Grants

  1. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
  2. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2010
  3. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1993
  4. Structure and Biomechanics of the Human Optic Nerve Head
    Donald J Brown; Fiscal Year: 2010
  5. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2010
  6. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted Acott; Fiscal Year: 2009
  7. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2010
  8. Admixture Mapping of Glaucoma Genes in African Americans
    Michael Hauser; Fiscal Year: 2009
  9. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2010
  10. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2010

Detail Information

Publications247 found, 100 shown here

  1. ncbi The association between glaucomatous visual fields and optic nerve head features in the Ocular Hypertension Treatment Study
    John L Keltner
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1603-12. 2006
    ..To determine the association between change from baseline in the optic nerve head (ONH) and the visual field (VF) during follow-up of ocular hypertension participants in the Ocular Hypertension Treatment Study...
  2. ncbi The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
    ..To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020...
  3. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
    ..To assess the prevalence and features of open-angle glaucoma in an urban population in southern India...
  4. ncbi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  5. ncbi Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, UK
    Exp Eye Res 90:750-7. 2010
    ..Such cascades of events initiated by ischemia to the optic nerve head region ultimately cause ganglion cells to die at different rates...
  6. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
    ..Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG...
  7. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
    ..Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role...
  8. ncbi Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009
    ..These findings suggest a pathway in the pathophysiology of glaucoma through loss of neurotrophic function and may eventually open the possibility of using ligands activating TrkB to prevent the progression of the disease...
  9. ncbi The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
    Khaled K Abu-Amero
    Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 14:518-22. 2008
    ..Glaucoma prevalence can vary geographically and ethnically, which suggests that a genetic element could play a significant role. Studies investigating the role of various mitochondrial haplogroups in the pathogenesis of glaucoma are scarce...
  10. ncbi Study of retinal nerve fibre layer thickness in eyes with high tension glaucoma and hemifield defect
    M S Kook
    Department of Ophthalmology, University of Ulsan, College of Medicine, Songpa Gu, Seoul, 138 736, Korea
    Br J Ophthalmol 85:1167-70. 2001
    ..To quantitatively evaluate retinal nerve fibre layer (RNFL) difference in areas of apparently normal appearing visual field in eyes with high tension glaucoma (HTG) and hemifield defects using scanning laser polarimetry...
  11. ncbi Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma
    Sergio Claudio Saccà
    Department of Neurosciences, Clinica Oculistica, University of Genoa, I 16132 Genoa, Italy
    Arch Ophthalmol 123:458-63. 2005
    ..To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration...
  12. ncbi Identification a novel MYOC gene mutation in a Chinese family with juvenile-onset open angle glaucoma
    Xin Zhao
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 16:1728-35. 2010
    To describe the clinical and genetic findings in one Chinese family with juvenile-onset open angle glaucoma (JOAG).
  13. ncbi Comparative evaluation of bimatoprost monotherapy in primary chronic angle closure and primary open angle glaucoma eyes: a three-year study
    Viney Gupta
    Department of Ophthalmology, Glaucoma Research Facility and Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 23:351-8. 2007
    The aim of this study was to compare the long-term efficacy of bimatoprost 0.03% monotherapy in primary open angle glaucoma (POAG) versus primary chronic angle closure glaucoma (PCACG) eyes.
  14. ncbi Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
    Masakazu Nakano
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Proc Natl Acad Sci U S A 106:12838-42. 2009
    ..These findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis...
  15. ncbi Five-year risk of progression of ocular hypertension to primary open angle glaucoma. A population-based study
    Ravi Thomas
    L V Prasad Eye Institute, Vellore, India
    Indian J Ophthalmol 51:329-33. 2003
    To report the progression of ocular hypertension (OHT) to primary open angle glaucoma (POAG) during a 5-year follow up of a population-based sample.
  16. ncbi Glaucomatous optic neuropathy: mechanisms of disease
    D Lynn Halpern
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmol Clin North Am 15:61-8. 2002
    ..Until evidence from clinical trials demonstrates the effectiveness of these agents however, control of IOP will remain the mainstay of treatment for glaucoma...
  17. ncbi Oxidative stress markers in aqueous humor of glaucoma patients
    Sandra M Ferreira
    Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
    Am J Ophthalmol 137:62-9. 2004
    ..For this purpose the authors measured the total reactive antioxidant potential (TRAP) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase...
  18. ncbi Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 13:667-76. 2007
    ..This study was designed to evaluate the involvement of the CYP1B1, MYOC, OPTN, and OPTC genes in the etiology of adult-onset primary open-angle glaucoma (POAG) found in 251 Indian patients...
  19. ncbi Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, and Barbados Family Study Group, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:17105-10. 2009
    ..Our approach illustrates the merit of using an isolated population enriched with common disease variants as an efficient method to identify genetic underpinning of POAG...
  20. ncbi Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Mol Vis 13:12-7. 2007
    Oxidative DNA damage has been shown to have some role in the development of primary open angle glaucoma (POAG)...
  21. ncbi Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
    ....
  22. ncbi Profiling of WDR36 missense variants in German patients with glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:270-4. 2008
    ..In this study, the prevalence of WDR36 variants was investigated in patients with glaucoma who were of German descent with diverse age of onset and intraocular pressure levels...
  23. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening...
  24. ncbi A genome-wide scan maps a novel autosomal dominant juvenile-onset open-angle glaucoma locus to 2p15-16
    Ying Lin
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 14:739-44. 2008
    ..To study the clinical features and to perform genetic linkage study in two large Chinese families with autosomal dominant juvenile-onset primary open-angle glaucoma (POAG)...
  25. ncbi Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields
    Pamela A Sample
    Visual Function, Department of Ophthalmology, University of California, La Jolla, 92093, USA
    Invest Ophthalmol Vis Sci 46:3684-92. 2005
    ..To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields...
  26. ncbi Temba glaucoma study: a population-based cross-sectional survey in urban South Africa
    Alan P Rotchford
    International Centre for Eye Health, The Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 110:376-82. 2003
    ..To determine the prevalence and features of glaucoma in an urban South African black population...
  27. ncbi Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1
    Karin Tosaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 51:417-23. 2007
    ..Heat-shock proteins (HSPs) or antibodies against them may contribute to glaucomatous optic neuropathy. We investigated the associations of HSP70-1 polymorphisms with open-angle glaucoma (OAG) in a Japanese population...
  28. ncbi Fine mapping of the GLC1K juvenile primary open-angle glaucoma locus and exclusion of candidate genes
    A Sud
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Mol Vis 14:1319-26. 2008
    ..The aim of this study is to refine the boundaries of the GLC1K region and to screen selected candidate genes located within the refined region for biologically significant mutations...
  29. ncbi Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery
    P R Lichter
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 108:1943-53. 2001
    ..Because 4 to 5 years of follow-up in a chronic disease is not adequate to draw treatment conclusions, these interim CIGTS outcomes do not support altering current treatment approaches to open-angle glaucoma...
  30. ncbi Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma
    Xiaobing Xie
    Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan, China
    Mol Vis 14:1666-72. 2008
    ..To investigate the genetic linkage of primary open-angle glaucoma (POAG) in a Chinese family...
  31. ncbi A randomised, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma
    M Nagar
    Department of Ophthalmology, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Ophthalmol 89:1413-7. 2005
    ..005% for the control of intraocular pressure (IOP) in ocular hypertension (OHT) and open angle glaucoma (OAG)...
  32. ncbi Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma
    Fuu Jen Tsai
    Department of Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 17:259-63. 2003
    ..In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital...
  33. ncbi Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism
    Christopher L Daugherty
    Department of Ophthalmology, West Virginia University, Morgantown, WV 26506, USA
    Mol Vis 15:1939-44. 2009
    ..The goal of this study was to examine the role of this polymorphism in susceptibility to POAG in a Caucasian population from the United States...
  34. ncbi Longitudinal glaucoma screening for siblings of patients with primary open angle glaucoma: the Nottingham Family Glaucoma Screening Study
    V C T Sung
    Eye, Ear, Nose and Throat Centre, Queen's Medical Centre University Hospital NHS Trust, Nottingham NG7 2UH, UK
    Br J Ophthalmol 90:59-63. 2006
    AIMS: To assess the prevalence and cumulative incidence of open angle glaucoma (OAG) in a cohort group of siblings of OAG probands...
  35. ncbi Causal inference in primary open angle glaucoma: specific discussion on intraocular pressure
    Hossein Bahrami
    Department of Ophthalmology, Johns Hopkins Schools of Medicine and Public Health, Johns Hopkins University, Baltimore, MD, USA
    Ophthalmic Epidemiol 13:283-9. 2006
    ..how causal inference is established in epidemiology and applies these methods to evaluate the evidence in favor or against the causal association between intraocular pressure (IOP) and primary open angle glaucoma (POAG) as an example.
  36. ncbi Novel LMX1B mutation in familial nail-patella syndrome with variable expression of open angle glaucoma
    Elena Milla
    Departamento de Oftalmologia, Hospital Clinic de Barcelona, Barcelona, Spain
    Mol Vis 13:639-48. 2007
    To describe the genetic and clinical findings in a large Spanish pedigree with nail-patella syndrome (NPS) and to investigate the expressivity of open angle glaucoma (OAG) in the family members.
  37. ncbi Study of retinal nerve fiber layer thickness within normal hemivisual field in primary open-angle glaucoma and normal-tension glaucoma
    Chiharu Matsumoto
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Jpn J Ophthalmol 47:22-7. 2003
    ..CONCLUSION: NFLT is already decreased when the visual field is still normal both in POAG eyes and in NTG eyes. However, the pattern of retinal nerve fiber layer damage in POAG may differ from that in NTG...
  38. ncbi Detection of early visual field loss in glaucoma using frequency-doubling perimetry and short-wavelength automated perimetry
    John A Landers
    Eye Associates and Save Sight Institute, Sydney University, Sydney, New South Wales, Australia
    Arch Ophthalmol 121:1705-10. 2003
    ..To investigate whether frequency-doubling perimetry (FDP) predicts future visual field loss with achromatic automated perimetry (AAP), just as it may be predicted with short-wavelength automated perimetry (SWAP)...
  39. ncbi Glaucomatous outflow pathway and oxidative stress
    Sergio Claudio Saccà
    San Martino Hospital, Section of Ophthalmology, Largo Rosanna Benzi 1, 16132 Genova, Italy
    Exp Eye Res 84:389-99. 2007
    ..On the whole, these findings support the hypothesis that oxidative damage is an important step in the pathogenesis of primary open-angle glaucoma, and might be a relevant target for both prevention and therapy...
  40. ncbi A comparison of the circadian rhythm of intraocular pressure in primary phronic angle closure glaucoma, primary open angle glaucoma and normal eyes
    Ramanjit Sihota
    Dr Rajendra Prasad Centre for Ophthalmic Science, All India Institute of Medical Science, New Delhi
    Indian J Ophthalmol 53:243-7. 2005
    To evaluate the circadian rhythm of intraocular pressure (IOP) in primary chronic angle closure glaucoma (PCACG), primary open angle glaucoma (POAG), and normal eyes.
  41. ncbi Long-term evaluation of trabeculectomy in primary open angle glaucoma and chronic primary angle closure glaucoma in an Asian population
    Ramanjit Sihota
    Dr Rajendra Prasad Centre of Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Clin Experiment Ophthalmol 32:23-8. 2004
    A retrospective cohort study was undertaken to evaluate and compare the long-term results of trabeculectomy in primary open angle glaucoma (POAG) and chronic primary angle closure glaucoma (CPACG) in an Asian population.
  42. ncbi Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes
    M Inatani
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Graefes Arch Clin Exp Ophthalmol 239:109-13. 2001
    ..0225) and the use of carbonic anhydrase inhibitors (P = 0.0143). CONCLUSIONS: Our results indicate that increased levels of TGF-beta 2 may play an important role in the pathogenesis of POAG...
  43. ncbi A review of the risk factors in primary open angle glaucoma
    A E Omoti
    Department of Ophthalmology, University ofBenin Teaching Hospital, Benin City, Nigeria
    Niger J Clin Pract 10:79-82. 2007
    ..If a particular patient is identified as having one or more of these risk factors, that patient is by definition, at greater risk of developing glaucoma than a patient who does not...
  44. ncbi Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma
    Oliver Arend
    Universitatsklinikum Aachen, Augenklinik der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Brain Res Bull 62:517-24. 2004
    To identify and quantify the role of retinal circulation, capillary leakage and/or nonperfusion of the optic nerve head in digital fluorescein angiography in normal subjects and patients with open angle glaucoma.
  45. ncbi Targeting relatives of patients with primary open angle glaucoma: the help the family glaucoma project
    Constance Nduaguba Okeke
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Glaucoma 16:549-55. 2007
    To assess the knowledge of patients with open angle glaucoma (OAG) and their family members about OAG risk factors and to study the referral of family members for eye examinations.
  46. ncbi Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma
    F S Weinand
    Department of Ophthalmology, University Eye Clinic, Giessen, Germany
    Eur J Ophthalmol 16:100-4. 2006
    ..To investigate the long-term efficacy of selective laser trabeculoplasty (SLT) in primary open-angle glaucoma, the authors performed a non-randomized, prospective, non-comparative clinical case series...
  47. ncbi The role of diurnal pressure measurements in the management of open angle glaucoma
    Jacob T Wilensky
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
    Curr Opin Ophthalmol 15:90-2. 2004
    ..This review will analyze recent articles that report the impact of various glaucoma therapies on the diurnal IOP curve and the use of diurnal curves in glaucoma diagnosis...
  48. ncbi Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype
    Ye Hong Zhuo
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 14:1533-9. 2008
    Glaucoma is the leading cause of irreversible blindness worldwide. Most of the cases are primary open angle glaucoma (POAG)...
  49. ncbi Glaucoma-associated WDR36 variants encode functional defects in a yeast model system
    Tim K Footz
    Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada
    Hum Mol Genet 18:1276-87. 2009
    ..These results demonstrate that, in the correct genetic background, WDR36 sequence variants can lead to an altered cellular phenotype, supporting the theory that WDR36 participates in polygenic forms of glaucoma...
  50. ncbi Prevalence of primary open angle glaucoma in general ophthalmic practice in the United Kingdom
    M Kroese
    Eastern Region Public Health Observatory, Institute of Public Health, Box 113, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Br J Ophthalmol 86:978-80. 2002
    AIM: To estimate the predicted prevalence of primary open angle glaucoma (POAG) from the activity of a local ophthalmology department...
  51. ncbi Analysis of risk factors that may be associated with progression from ocular hypertension to primary open angle glaucoma
    John Landers
    Eye Associates, Sydney University, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 30:242-7. 2002
    ..Ocular hypertension (OHT) may develop into primary open angle glaucoma (POAG) for many patients...
  52. ncbi Primary open angle glaucoma was not found to be associated with p53 codon 72 polymorphism in a Brazilian cohort
    R E Silva
    Pronto Clínica de Olhos, Goiania, GO, Brazil
    Genet Mol Res 8:268-72. 2009
    Primary open angle glaucoma (POAG) is the most common type of glaucoma...
  53. ncbi Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma
    Paloma B Liton
    Department of Ophthalmology, Duke University, Durham, NC 27710, USA
    Autophagy 5:122-4. 2009
    Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow ..
  54. ncbi Ocular pulse amplitude in normal tension and primary open angle glaucoma
    Ingeborg Stalmans
    Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
    J Glaucoma 17:403-7. 2008
    ..1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG)...
  55. ncbi Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 115:763-8. 2008
    ..To compare cerebrospinal fluid (CSF) pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients...
  56. ncbi Mitochondrial dysfunction and glaucoma
    George Y X Kong
    Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Australia
    J Glaucoma 18:93-100. 2009
    ..b>Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying ..
  57. ncbi Screening for open angle glaucoma: systematic review of cost-effectiveness studies
    Rodolfo Hernandez
    Health Economics Research Unit, University of Aberdeen, Aberdeen, Scotland, UK
    J Glaucoma 17:159-68. 2008
    To systematically review current evidence on the cost-effectiveness of screening strategies for open angle glaucoma (OAG).
  58. ncbi Rapid mutation detection by the transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma
    C J Cobb
    Department of Ophthalmology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Ophthalmol 86:191-5. 2002
    AIMS: To rapidly screen Scottish patients with a family history of open angle glaucoma (OAG) or ocular hypertension (OHT) for mutations in the myocilin gene (MYOC) and develop a new rapid screening method for MYOC mutation detection...
  59. ncbi Anterior chamber flare after trabeculectomy and after phacoemulsification
    D Siriwardena
    Institute of Ophthalmology, London EC1V 9EL, UK
    Br J Ophthalmol 84:1056-7. 2000
    ..To evaluate and compare prospectively the anterior chamber inflammatory response after phacoemulsification cataract surgery and after trabeculectomy with peripheral iridectomy...
  60. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
    ..To assess factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of EMGT treatment...
  61. ncbi Cigarette smoking and primary open angle glaucoma: a systematic review
    Richard Edwards
    Department of Public Health, University of Otago, Wellington, New Zealand
    J Glaucoma 17:558-66. 2008
    To evaluate the epidemiologic evidence for a causal association between tobacco smoking and primary open angle glaucoma (POAG).
  62. ncbi Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population
    Fumihiko Mabuchi
    Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Mol Vis 15:1045-9. 2009
    To assess whether tumor protein p53 gene (p53) polymorphisms are associated with primary open angle glaucoma (POAG) in the Japanese population.
  63. ncbi Persistence and adherence with topical glaucoma therapy
    Beth L Nordstrom
    Ingenix Epidemiology, Auburndale, Massachusetts 02466, USA
    Am J Ophthalmol 140:598-606. 2005
    ..The present study describes the patterns and predictors of treatment persistence and adherence among patients who are diagnosed with glaucoma or as glaucoma suspects (based on claims codes)...
  64. ncbi Clinical outcomes of glaucoma treatments over a patient lifetime: a Markov model
    Jean Philippe Nordmann
    , Centre Hospitalier National d'Ophtalmologie, Paris, France
    J Glaucoma 14:463-9. 2005
    ..CONCLUSION: More powerful glaucoma medication (first-line or second-line) would contribute to the preservation of long-term vision...
  65. ncbi Glaucoma follow-up by the Heidelberg retina tomograph--new graphical analysis of optic disc topography changes
    Lada Kalaboukhova
    Section of Ophthalmology, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, 431 80 Mölndal, Sweden
    Graefes Arch Clin Exp Ophthalmol 244:654-62. 2006
    ....
  66. ncbi Association between localized visual field losses and thickness deviation of the nerve fiber layer in glaucoma
    Folkert K Horn
    Department of Ophthalmology and University Eye Hospital, Friedrich Alexander University Erlangen Nürnberg at Erlangen, Germany
    J Glaucoma 14:419-25. 2005
    ..To perform a correlation between morphology and function by studying local perimetric field losses and thickness reduction of the nerve layer in corresponding areas...
  67. ncbi Normal visual field test results following glaucomatous visual field end points in the Ocular Hypertension Treatment Study
    John L Keltner
    Visual Field Reading Center, Department of Ophthalmology, University of California Davis, 4860 Y Street, Ste 2400, Sacramento, CA 95817, USA
    Arch Ophthalmol 123:1201-6. 2005
    ..To compare the occurrence of normal visual field (VF) test results following 2 vs 3 consecutive, abnormal, reliable test results in the Ocular Hypertension Treatment Study...
  68. ncbi Correlation between frequency doubling technology and heidelberg retina tomograph
    Michele Iester
    Department of Neurological Sciences, Ophthalmology, Genetic, Clinica Oculistica, University of Genoa, Genoa, Italy
    J Glaucoma 14:368-74. 2005
    To evaluate the association between Heidelberg Retina Tomograph (HRT) parameters and the Frequency Doubling Technology (FDT) indices in ocular hypertension or primary open angle glaucoma patients.
  69. ncbi No changes in anatomical and functional glaucoma evaluation after trabeculectomy
    Ivan Maynart Tavares
    Department of Ophthalmology, Federal University of Sao Paulo, Rua Botucatu, 822, Sao Paulo, Brazil
    Graefes Arch Clin Exp Ophthalmol 244:545-50. 2006
    ..To assess the influence of glaucoma filtration surgery on anatomical and functional tests for glaucoma evaluation...
  70. ncbi Variations in treatment among adult-onset open-angle glaucoma patients
    David S Friedman
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ophthalmology 112:1494-9. 2005
    ..To determine the predictors of treatment for glaucoma and suspect glaucoma in a nationally representative sample of diagnosed persons...
  71. ncbi Evaluation of practice patterns for the care of open-angle glaucoma compared with claims data: the Glaucoma Adherence and Persistency Study
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:1599-606. 2007
    ..To perform a chart review to measure the validity of large claims databases in estimating patient cooperation with eyedrop therapy and to assess physician adherence with guidelines for a preferred practice pattern (PPP) using a new metric...
  72. ncbi Intereye spatial relationship of abnormal neuroretinal rim locations in glaucoma patients from the diagnostic innovations in glaucoma study
    Esther M Hoffmann
    Hamilton Glaucoma Center, Department of Ophthalmology, UC San Diego, La Jolla, California 92093, USA
    Am J Ophthalmol 143:781-7. 2007
    ..To determine the spatial relationship in neuroretinal rim parameter values between eyes in ocular hypertensives, glaucoma suspects, and glaucoma patients...
  73. ncbi Fluctuating intraocular pressure
    David Broadway
    Norfolk and Norwich University Hospital, Norwich, United Kingdom
    J Glaucoma 14:249-51. 2005
  74. ncbi the impact of definition of primary open-angle glaucoma on the cross-sectional assessment of diagnostic validity of Heidelberg retinal tomography
    Stefano Miglior
    Department of Ophthalmology, University of Milan Bicocca, Department of Neurosciences and Biomedical Technologies, Policlinico di Monza, Via Amati 111, 20052 Monza, Milan, Italy
    Am J Ophthalmol 139:878-87. 2005
    To evaluate the impact of different definitions of primary open angle glaucoma (POAG) on assessment of the diagnostic validity of Heidelberg Retinal Tomography (HRT).
  75. ncbi Long-term reproducibility of screening for glaucoma with FDT-perimetry
    Folkert K Horn
    Department of Ophthalmology and University Eye Hospital, Friedrich Alexander University Erlangen Nürnberg at Erlangen, Germany
    J Glaucoma 16:448-55. 2007
    ..Aim of this study was to evaluate the long-term reproducibility of frequency doubling technology (FDT) screening procedures...
  76. ncbi Correlation of Disc Damage Likelihood Scale, visual field, and Heidelberg Retina Tomograph II in patients with glaucoma
    J Hornova
    Third Faculty of Medicine, Charles University, University Hospital Královské Vinohrady and IPVZ, Prague Czech Republic
    Eur J Ophthalmol 18:739-47. 2008
    ....
  77. ncbi Effect of latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma
    Shingo Ishibashi
    Department of Ophthalmology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Glaucoma 15:354-7. 2006
    ..To evaluate the effects of latanoprost on the diurnal variations in the intraocular pressure (IOP) combined with the ocular perfusion pressure (OPP) in patients with normal tension glaucoma (NTG)...
  78. ncbi Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage
    Jost B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Experiment Ophthalmol 34:654-60. 2006
    ..To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression...
  79. ncbi Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study
    Richard A Levine
    Department of Mathematics and Statistics, San Diego State University, San Diego, California 92182, USA
    Invest Ophthalmol Vis Sci 47:3896-903. 2006
    ..To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants...
  80. ncbi Keratometry, optic disc dimensions, and degree and progression of glaucomatous optic nerve damage
    Jost B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    J Glaucoma 15:206-12. 2006
    ..To evaluate whether keratometric readings as a measure of corneal shape are associated with optic disc dimensions and with the degree and rate of perimetric progression of chronic open-angle glaucoma or ocular hypertension...
  81. ncbi Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Ophthalmology 114:10-9. 2007
    ....
  82. ncbi Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial
    Boel Bengtsson
    Department of Clinical Sciences, Ophthalmology, Lund University, Malmo University Hospital, Malmo, Sweden
    Ophthalmology 114:205-9. 2007
    ..To investigate whether increased fluctuation of intraocular pressure (IOP) is an independent factor for glaucoma progression...
  83. ncbi Visual field testing with the new Humphrey Matrix: a comparison between the FDT N-30 and Matrix N-30-F tests
    Paolo Brusini
    Department of Ophthalmology, Santa Maria della Misericordia Hospital, Udine, Italy
    Acta Ophthalmol Scand 84:351-6. 2006
    ..To determine if the N-30-F test with the new Humphrey Matrix instrument is comparable to the traditional frequency-doubling technology (FDT) N-30 test...
  84. ncbi Relationship between central corneal thickness and changes of optic nerve head topography and blood flow after intraocular pressure reduction in open-angle glaucoma and ocular hypertension
    Mark R Lesk
    Department of Ophthalmology, University of Montreal, Montreal, Quebec
    Arch Ophthalmol 124:1568-72. 2006
    ..To investigate changes in optic nerve head topography and blood flow after therapeutic intraocular pressure reduction and to correlate them with central corneal thickness...
  85. ncbi The ISNT rule and differentiation of normal from glaucomatous eyes
    Noga Harizman
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York University School of Medicine, New York, NY 10003, USA
    Arch Ophthalmol 124:1579-83. 2006
    ..04 (95% confidence interval, 1.74-20.95) after adjustment for age; race was not a confounder of this association. CONCLUSION: The ISNT rule is useful in differentiating normal from glaucomatous optic nerves and is unaffected by race...
  86. ncbi Automated flicker perimetry in glaucoma using Octopus 311: a comparative study with the Humphrey Matrix
    Chota Matsumoto
    Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
    Acta Ophthalmol Scand 84:210-5. 2006
    ..We evaluated the clinical usefulness of flicker perimetry in glaucoma and glaucoma suspect patients using the new Octopus 311 automated perimeter...
  87. ncbi Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension
    Gabriele Fuchsjager-Mayrl
    Departments of Clinical Pharmacology and Ophthalmology, and the Institute of Medical Physics, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 45:834-9. 2004
    ..In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and dorzolamide were compared...
  88. ncbi Glaucomatous damage in normotensive fellow eyes of patients with unilateral hypertensive pseudoexfoliation glaucoma: normotensive pseudoexfoliation glaucoma?
    Alper Yarangumeli
    Eye Clinic I, Ankara Numune Training and Research Hospital, A Ayranci 06540, Ankara, Turkey
    Clin Experiment Ophthalmol 34:15-9. 2006
    ..The objective of the study was to investigate the prevalence of glaucomatous damage in normotensive fellow eyes of patients with unilateral high-tension pseudoexfoliation (PX) glaucoma...
  89. ncbi Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular hypertension and glaucoma
    Vincenzo Parisi
    Fondazione per l Oftalmologia G B Bietti IRCCS, Rome, Italy
    Ophthalmology 113:216-28. 2006
    ..To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP) responses in patients with ocular hypertension or open-angle glaucoma (OAG)...
  90. ncbi Clinical outcomes of glaucoma treatment over a patient lifetime: a Markov model (letter)
    Steven Kymes
    J Glaucoma 15:471-2; author reply 472-3. 2006
  91. ncbi Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in glaucoma detection
    Folkert K Horn
    Department of Ophthalmology and University Eye Hospital, Friedrich Alexander University Erlangen Nürnberg at Erlangen, Erlangen, Germany
    Am J Ophthalmol 135:160-8. 2003
    ..The aim of this study was to evaluate the diagnostic usefulness of the combined use of frequency-doubling technology (FDT) perimetry and polarimetry of the retinal nerve fiber layer...
  92. ncbi How are glaucoma patients identified?
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Glaucoma 12:451-5. 2003
    ..To determine the events that lead to the diagnosis of glaucoma...
  93. ncbi Racial differences in optic disc topography: baseline results from the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study
    Linda M Zangwill
    Department of Ophthalmology, University of California, San Diego, La Jolla 92093, USA
    Arch Ophthalmol 122:22-8. 2004
    ..To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study...
  94. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ....
  95. ncbi Emerging perspectives in glaucoma: optimizing 24-hour control of intraocular pressure
    Martin B Wax
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 133:S1-10. 2002
    ..To explore recent studies and clinical experience involving the importance of 24-hour control of intraocular pressure (IOP) in patients with glaucoma...
  96. ncbi Identifying early glaucoma with optical coherence tomography
    Kouros Nouri-Mahdavi
    Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Am J Ophthalmol 137:228-35. 2004
    ..CONCLUSION: The OCT discriminates well between eyes with early perimetric glaucoma and normal eyes. However, its performance is less adequate in eyes with suspicious disk and normal VFs...
  97. ncbi Clinical decision making based on data from GDx: one-year observations
    James C Bobrow
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Trans Am Ophthalmol Soc 100:131-5; discussion 135-6. 2002
    ..Changing medications without significantly reducing IOP may be insufficient to halt increases in GDx numbers and may indicate a need for more aggressive therapy...
  98. ncbi Relationship between Humphrey 30-2 SITA Standard Test, Matrix 30-2 threshold test, and Heidelberg retina tomograph in ocular hypertensive and glaucoma patients
    Banu Bozkurt
    Private Practice, Hacettepe University School of Medicine, Ankara, Turkey
    J Glaucoma 17:203-10. 2008
    ....
  99. ncbi Optic disc biomorphometry with the Heidelberg Retina Tomograph at different reference levels
    Kyösti Vihanninjoki
    Department of Ophthalmology, University of Oulu, Oulu, Finland
    Acta Ophthalmol Scand 80:47-53. 2002
    ..The purpose of the present study was to evaluate the four different reference levels in terms of their advantages and disadvantages in clinical work...
  100. ncbi Changes in central corneal thickness over time: the ocular hypertension treatment study
    James D Brandt
    Department of Ophthalmology and Vision Science, University of California, Sacramento, California, USA
    Ophthalmology 115:1550-6, 1556.e1. 2008
    ....
  101. ncbi Correlation between intraocular pressure level and optic disc changes in high-tension glaucoma suspects
    Masaki Tanito
    Senshokai Eye Institute, Kyoto, Japan
    Ophthalmology 110:915-21. 2003
    ....

Research Grants75

  1. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    Primary open angle glaucoma (POAG) is one of the four major causes of blindness and visual disability. Two million people in the United States have glaucoma; 100,000 of them are blind...
  2. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2010
    ..Elevated intraocular pressure (IOP) is a prominent risk factor as seen in primary open angle glaucoma (POAG)...
  3. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1993
    ..Since primary open angle glaucoma (POAG) is known to be an age- related disorder, specimens obtained from donors of three different age ..
  4. Structure and Biomechanics of the Human Optic Nerve Head
    Donald J Brown; Fiscal Year: 2010
    Primary open angle glaucoma (POAG) represents a serious and growing health problem accounting for ~12% of global blindness...
  5. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2010
    ..These studies are focused at understanding the molecular nature of the aqueous humor outflow pathway, which is normally responsible for avoiding glaucoma and which becomes obstructed to produce glaucoma. ..
  6. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted Acott; Fiscal Year: 2009
    ..These studies are focused at understanding the molecular nature of the aqueous humor outflow pathway, which is normally responsible for avoiding glaucoma and which becomes obstructed to produce glaucoma. ..
  7. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2010
    ..Steroid-induced open angle glaucoma is caused by a decrease of trabecular meshwork (TM) outflow facility...
  8. Admixture Mapping of Glaucoma Genes in African Americans
    Michael Hauser; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  9. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2010
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  10. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2010
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  11. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    ROBERT WORDINGER; Fiscal Year: 2009
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  12. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    ROBERT WORDINGER; Fiscal Year: 2009
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  13. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2009
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  14. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  15. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  16. GLAUCOMA-CONNECTIVE TISSUE CHANGES IN OPTIC NERVE HEAD
    M Rosario Hernandez; Fiscal Year: 2007
    Our long-term objective is to determine how astrocytes contribute to optic neuropathy in primary open angle glaucoma (POAG)...
  17. OCULAR ACTIONS OF ENDOTHELINS
    Thomas Yorio; Fiscal Year: 2005
    ..Recently, it has been shown that patients with primary open angle glaucoma (POAG) have an elevation in their aqueous humor endothelin (ET) concentrations...
  18. Glucocorticoids, Ocular Hypertension and Glaucoma
    Thomas Yorio; Fiscal Year: 2009
    ..These specific aims are designed to determine if GRbeta regulates GC responsiveness and if decreases in its expression contribute to ocular hypertension often seen in patients with POAG. ..