glaucoma

Summary

Summary: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Top Publications

  1. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
  2. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  3. pmc Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    J Clin Invest 121:1429-44. 2011
  4. doi Glaucoma
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Lancet 377:1367-77. 2011
  5. pmc IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
    Beatriz I Gallego
    Instituto de Investigaciones Oftalmologicas Ramon Castroviejo, Universidad Complutense de Madrid, Madrid, 28040, Spain
    J Neuroinflammation 9:92. 2012
  6. ncbi False-negative responses in glaucoma perimetry: indicators of patient performance or test reliability?
    B Bengtsson
    Department of Ophthalmology, Malmo University Hospital, Sweden
    Invest Ophthalmol Vis Sci 41:2201-4. 2000
  7. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
  8. pmc Null mutations in LTBP2 cause primary congenital glaucoma
    Manir Ali
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Am J Hum Genet 84:664-71. 2009
  9. doi Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
    Ileana Soto
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:548-61. 2008
  10. doi Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma
    Sung Chul Park
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Ophthalmology 119:3-9. 2012

Research Grants

Detail Information

Publications344 found, 100 shown here

  1. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
    To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020.
  2. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..The vascular theory of glaucoma considers GON as a consequence of insufficient blood supply due to either increased IOP or other risk factors ..
  3. pmc Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    J Clin Invest 121:1429-44. 2011
    b>Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest stages of this complex disease are still unclear. This study was specifically designed to identify early stages of glaucoma in DBA/2J mice...
  4. doi Glaucoma
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Lancet 377:1367-77. 2011
    Most medical practitioners have regular contact with adults who have one of the two forms of glaucoma: open-angle glaucoma or angle-closure glaucoma...
  5. pmc IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
    Beatriz I Gallego
    Instituto de Investigaciones Oftalmologicas Ramon Castroviejo, Universidad Complutense de Madrid, Madrid, 28040, Spain
    J Neuroinflammation 9:92. 2012
    Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons...
  6. ncbi False-negative responses in glaucoma perimetry: indicators of patient performance or test reliability?
    B Bengtsson
    Department of Ophthalmology, Malmo University Hospital, Sweden
    Invest Ophthalmol Vis Sci 41:2201-4. 2000
    To study whether false-negative answers in computerized glaucoma perimetry indicate the patient's ability to perform perimetry or test result reliability.
  7. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, ..
  8. pmc Null mutations in LTBP2 cause primary congenital glaucoma
    Manir Ali
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Am J Hum Genet 84:664-71. 2009
    Primary congenital glaucoma (PCG) is an autosomal-recessive condition characterized by high intraocular pressure (IOP), usually within the first year of life, which potentially could lead to optic nerve damage, globe enlargement, and ..
  9. doi Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
    Ileana Soto
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:548-61. 2008
    Little is known about molecular changes occurring within retinal ganglion cells (RGCs) before their death in glaucoma. Taking advantage of the fact that gamma-synuclein (Sncg) mRNA is expressed specifically and highly in adult mouse RGCs, ..
  10. doi Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma
    Sung Chul Park
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Ophthalmology 119:3-9. 2012
    To assess the usefulness of enhanced depth imaging (EDI) optical coherence tomography (OCT) for evaluating deep structures of the optic nerve complex (ONC; optic nerve head and peripapillary structures) in glaucoma.
  11. doi The molecular basis of retinal ganglion cell death in glaucoma
    Mohammadali Almasieh
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada
    Prog Retin Eye Res 31:152-81. 2012
    b>Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that results in visual field loss and irreversible blindness...
  12. ncbi Neuronal death in glaucoma
    H A Quigley
    Glaucoma Service and the Dana Center for Preventive Ophthalmology, Wilmer Inst, Johns Hopkins University School of Medicine, Baltimore, MD 21287-9205, USA
    Prog Retin Eye Res 18:39-57. 1999
    b>Glaucoma is recognized to have its major detrimental effect upon the eye by killing retinal ganglion cells...
  13. pmc Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement
    Elma E Chang
    University of Miami Miller School of Medicine, Miami, FL, USA
    Ophthalmology 119:979-86. 2012
    b>Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs) associated with characteristic axon degeneration in the optic nerve...
  14. ncbi Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye
    David Goldblum
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, USA
    Vision Res 42:471-8. 2002
    ..Here we review the different, current models in rodents that have been used to study RGC damage, discuss their value, and their adequacy as models for human glaucoma.
  15. pmc A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma
    Claude F Burgoyne
    Optic Nerve Head Research Laboratory, Part of the Discoveries in Sight Research Laboratories of the Devers Eye Institute, Legacy Health System, 1225 NE 2nd Ave, Portland, OR 97232, USA
    Exp Eye Res 93:120-32. 2011
    ..determinants of retinal ganglion cell axon physiology within the ONH in the optic neuropathy of aging and Glaucoma. My goal is to provide a biomechanical framework for this discussion...
  16. pmc Glaucoma: genes, phenotypes, and new directions for therapy
    Bao Jian Fan
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3064-72. 2010
    b>Glaucoma, a leading cause of blindness worldwide, is characterized by progressive optic nerve damage, usually associated with intraocular pressure...
  17. doi Barriers to adherence with glaucoma medications: a qualitative research study
    J Lacey
    Department of Ophthalmology, Glaucoma Research Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK
    Eye (Lond) 23:924-32. 2009
    b>Glaucoma is initially asymptomatic, but untreated can result in progressive visual field loss and eventual blindness...
  18. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
    ..the optic nerve head (ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in experimental glaucoma (EG) and whether these changes are detectable at the onset of Heidelberg Retina Tomography (HRT; Heidelberg ..
  19. doi Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma
    Brian P Buckingham
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 28:2735-44. 2008
    b>Glaucoma is characterized by retinal ganglion cell (RGC) pathology and a progressive loss of vision...
  20. doi Oxidative stress and mitochondrial dysfunction in glaucoma
    Vicki Chrysostomou
    Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia
    Curr Opin Pharmacol 13:12-5. 2013
    ..Recent reports have also demonstrated oxidative stress in ocular tissues derived from experimental glaucoma models and clinical samples...
  21. pmc Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection
    Frances E Cone
    Glaucoma Research Laboratory, Johns Hopkins University School of Medicine, Wilmer Institute, Wilmer 122, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Exp Eye Res 91:415-24. 2010
    ..was to test the susceptibility to retinal ganglion cell (RGC) axon loss and RGC layer cell loss from experimental glaucoma among 3 mouse strains, and between younger and older mice...
  22. pmc The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
    Takayuki Harada
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 117:1763-70. 2007
    b>Glaucoma, a progressive optic neuropathy due to retinal ganglion cell (RGC) degeneration, is one of the leading causes of irreversible blindness...
  23. doi Retinal protection from acute glaucoma-induced ischemia-reperfusion injury through pharmacologic induction of heme oxygenase-1
    Ming Hui Sun
    Department of Ophthalmology, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
    Invest Ophthalmol Vis Sci 51:4798-808. 2010
    ....
  24. pmc Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma
    Michael D Roberts
    Ocular Biomechanics Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 50:681-90. 2009
    ..of the lamina cribrosa (LC) in terms of total connective tissue volume (CTV), connective tissue volume fraction (CTVF), predominant beam orientation, and material anisotropy in monkeys with early experimental glaucoma (EG).
  25. ncbi Visual field defects and the risk of motor vehicle collisions among patients with glaucoma
    Gerald McGwin
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294 0009, USA
    Invest Ophthalmol Vis Sci 46:4437-41. 2005
    To evaluate the association between visual field defects in the central 24 degrees field and the risk of motor vehicle collisions (MVCs) among patients with glaucoma.
  26. pmc Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma
    Shazia Micheal
    Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 18:1040-4. 2012
    ..in the lysyl oxidase-like 1 (LOXL1) gene have been previously reported to be associated with pseudoexfoliation glaucoma (PEXG) in various Asian and European populations, but these SNPs have not yet been studied in the Pakistani ..
  27. doi The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Exp Eye Res 93:141-55. 2011
    b>Glaucoma is an optic neuropathy of unknown origin. The most important risk factor for the disease is an increased intraocular pressure (IOP). Reducing IOP is associated with reduced progression in glaucoma...
  28. pmc Spectral domain optical coherence tomography for glaucoma (an AOS thesis)
    Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Trans Am Ophthalmol Soc 106:426-58. 2008
    ..SD-OCT enables novel scanning, denser sampling, and 3-dimensional imaging. This thesis tests my hypothesis that SD-OCT improves reproducibility, sensitivity, and specificity for glaucoma detection.
  29. doi Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration
    Yeni Yucel
    Department of Ophthalmology and Vision Sciences, Keenan Research Centre at the Li Ka Shing, Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Prog Brain Res 173:465-78. 2008
    ..b>Glaucoma is a disease of visual neurons in the eye and brain...
  30. pmc Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma
    Judy V Nguyen
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:1176-81. 2011
    Optic nerve head (ONH) astrocytes have been proposed to play both protective and deleterious roles in glaucoma. We now show that, within the postlaminar ONH myelination transition zone (MTZ), there are astrocytes that normally express Mac-..
  31. ncbi Comparison of trabeculectomy with Ex-PRESS miniature glaucoma device implanted under scleral flap
    Peter J G Maris
    Hamilton Eye Institute, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    J Glaucoma 16:14-9. 2007
    ..To evaluate the Ex-PRESS miniature implant (Model R 50) placed under partial-thickness scleral flap compared with standard trabeculectomy...
  32. pmc Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    Tatjana C Jakobs
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
    J Cell Biol 171:313-25. 2005
    ..and triple labeling techniques, we have reevaluated the death of retinal neurons in a mouse model of hereditary glaucoma. Cell-specific markers and total neuron counts revealed no cell loss in any retinal neurons other than the ..
  33. ncbi Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program
    Hwa Sun Kim
    Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Ku, Seoul 137 701, South Korea
    Brain Res 1057:17-28. 2005
    ..survival factors triggered at the early stage of injury play a critical role in control of the death or survival of retinal ganglion cells and that the manipulation of this decision phase is one of the therapeutic targets for glaucoma.
  34. ncbi Changes in aqueous humor dynamics with age and glaucoma
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 340 CSC, 600 Highland Avenue, Madison, WI 53792 3220, USA
    Prog Retin Eye Res 24:612-37. 2005
    Changes in aqueous humor dynamics with age and in glaucoma have been studied for several decades...
  35. ncbi The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
    D Y Nishimura
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Nat Genet 19:140-7. 1998
    A number of different eye disorders with the presence of early-onset glaucoma as a component of the phenotype have been mapped to human chromosome 6p25...
  36. doi Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients
    Markus Bock
    Cecilie Vogt Clinic, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Clin Neurol Neurosurg 112:647-52. 2010
    ..of retinal nerve fiber layer thickness (RNFLT) loss are different in MS compared to other diseases such as glaucoma and data on RNFLT loss in MS patients with or without optic neuritis (ON/NON) have remained inconsistent or even ..
  37. doi Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury
    Andreas Ebneter
    South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    Invest Ophthalmol Vis Sci 51:6448-60. 2010
    ..The aim of the current work was to characterize the microglial response within the visual pathway in a rat model of experimental glaucoma and to correlate the microglial response with the severity of axonal degeneration.
  38. pmc Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, School of Medicine, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:4903-11. 2008
    ..To determine whether elevation of intraocular pressure (IOP) triggers mitochondrial fission and ultrastructural changes and alters optic atrophy type 1 (OPA1) expression and distribution in the optic nerve (ON) of glaucomatous DBA/2J mice...
  39. ncbi High occurrence rate of glaucoma among patients with Alzheimer's disease
    A U Bayer
    Department of Ophthalmology, Hospital of Weilheim Schongau, Weilheim, Germany
    Eur Neurol 47:165-8. 2002
    The purpose of the current study was to reveal the occurrence rate of glaucoma among patients with Alzheimer's disease (AD)...
  40. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  41. ncbi Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
    Anna L Mead
    Wound Healing Unit, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:3394-401. 2003
    Postoperative subconjunctival wound healing remains the commonest cause of late bleb failure after glaucoma filtration surgery...
  42. ncbi Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA
    Curr Opin Ophthalmol 15:102-6. 2004
    This review summarizes factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of treatment...
  43. doi Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Neurosci 35:153-79. 2012
    b>Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million people by the end of this decade...
  44. pmc Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing
    Baptiste Coudrillier
    Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Invest Ophthalmol Vis Sci 53:1714-28. 2012
    The objective of this study was to measure the biomechanical response of the human posterior sclera in vitro and to estimate the effects of age and glaucoma.
  45. doi Collagen-related genes influence the glaucoma risk factor, central corneal thickness
    Eranga N Vithana
    Singapore Eye Research Institute, Singapore
    Hum Mol Genet 20:649-58. 2011
    Central corneal thickness (CCT) is a risk factor of glaucoma, the most common cause of irreversible blindness worldwide...
  46. doi Effect of spectrum bias on the diagnostic accuracy of spectral-domain optical coherence tomography in glaucoma
    Harsha L Rao
    VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India
    Invest Ophthalmol Vis Sci 53:1058-65. 2012
    To evaluate the influence of a control group on the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) in early glaucoma.
  47. pmc The definition and classification of glaucoma in prevalence surveys
    Paul J Foster
    Department of Epidemiology and International Eye Health, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Br J Ophthalmol 86:238-42. 2002
    This review describes a scheme for diagnosis of glaucoma in population based prevalence surveys. Cases are diagnosed on the grounds of both structural and functional evidence of glaucomatous optic neuropathy...
  48. pmc Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma
    Thomas V Johnson
    Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 51:2051-9. 2010
    Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by ..
  49. pmc The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:745-51. 2007
    ..characteristics, reliability, and dynamic range of the pattern electroretinogram (PERG) as a tool to monitor progressive RGC dysfunction in the DBA/2J mouse model of glaucoma with spontaneously elevated intraocular pressure (IOP).
  50. ncbi Driving performance of glaucoma patients correlates with peripheral visual field loss
    Janet P Szlyk
    Research and Development Service, Jesse Brown Department of Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    J Glaucoma 14:145-50. 2005
    To identify clinical vision measures that are associated with the driving performance of glaucoma patients who have visual field loss and visual acuity better than 20/100 and to compare the driving performance of glaucoma patients with ..
  51. doi Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice
    Kazuhiko Namekata
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neurosci Lett 465:160-4. 2009
    b>Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of retinal ganglion cells (RGCs) and optic nerves...
  52. doi Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography
    Kohei Takayama
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 54:4798-807. 2013
    ..To visualize lamina cribrosa defects using three-dimensional (3D) swept-source optical coherence tomography (SS-OCT), and to determine the factors associated with this feature...
  53. doi Neuroprotection in glaucoma - Is there a future role?
    Abeir Baltmr
    Glaucoma and Retinal Neurodegeneration Research Group, Visual Neurosciences Department, University College London Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Exp Eye Res 91:554-66. 2010
    In glaucoma, the major cause of global irreversible blindness, there is an urgent need for treatment modalities that directly target the RGCs...
  54. pmc Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography
    Ou Tan
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 116:2305-14.e1-2. 2009
    To map ganglion cell complex (GCC) thickness with high-speed Fourier-domain optical coherence tomography (FD-OCT) and compute novel macular parameters for glaucoma diagnosis.
  55. doi Brain involvement in glaucoma: advanced neuroimaging for understanding and monitoring a new target for therapy
    Carlo Nucci
    Ophthalmology Unit, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Opin Pharmacol 13:128-33. 2013
    On the basis of a large body of experimental data the notion that glaucoma damages retinal ganglion cells and central areas of the visual system has been put forward...
  56. pmc Critical pathogenic events underlying progression of neurodegeneration in glaucoma
    David J Calkins
    Department of Ophthalmology and Visual Sciences, The Vanderbilt Eye Institute, Vanderbilt University School of Medicine, 11435 MRB IV, 2215B Garland Avenue, Nashville, TN 37232, USA
    Prog Retin Eye Res 31:702-19. 2012
    b>Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to intraocular pressure...
  57. doi New insights in the pathogenesis and treatment of normal tension glaucoma
    Maneli Mozaffarieh
    University of Basel, Department of Ophthalmology, Basel, Switzerland
    Curr Opin Pharmacol 13:43-9. 2013
    ..a disturbed OBF autoregulation is a primary vascular dysregulation (PVD) frequently observed in normal tension glaucoma patients...
  58. doi Assessment of lateral geniculate nucleus atrophy with 3T MR imaging and correlation with clinical stage of glaucoma
    H Dai
    Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology University, Wuhan, China
    AJNR Am J Neuroradiol 32:1347-53. 2011
    ..changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage...
  59. pmc Glaucoma awareness among people attending ophthalmic outreach services in Southwestern Ethiopia
    Addis Tenkir
    Department of Ophthalmology, Collage of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia
    BMC Ophthalmol 10:17. 2010
    Individuals may need to be aware of glaucoma and seek assessment regularly in order to diagnose the condition early. Awareness of glaucoma has not been previously documented in an Ethiopian setting.
  60. pmc Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma
    Giedrius Kalesnykas
    Department of Ophthalmology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Invest Ophthalmol Vis Sci 53:3847-57. 2012
    To study sequential changes in retinal ganglion cell (RGC) morphology in mice after optic nerve crush and after induction of experimental glaucoma.
  61. doi Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis
    Harsha L Rao
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, California 92093 0946, USA
    Ophthalmology 117:1692-9, 1699.e1. 2010
    To evaluate retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular thickness measurements for glaucoma detection using the RTVue spectral domain optical coherence tomograph.
  62. doi Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
    Kang Zhang
    Department of Ophthalmology and Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Nat Rev Drug Discov 11:541-59. 2012
    ..leading causes of irreversible blindness include age-related macular degeneration, retinal vascular diseases and glaucoma. The unique features of the eye provide both benefits and challenges for drug discovery and delivery...
  63. ncbi Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model
    Frank Schuettauf
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Vision Res 42:2333-7. 2002
    We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse...
  64. doi Prediction of glaucomatous visual field loss by extrapolation of linear trends
    Boel Bengtsson
    Departments of Clinical Sciences and Ophthalmology, Lund University, Malmo University Hospital, SE 20502 Malmo, Sweden
    Arch Ophthalmol 127:1610-5. 2009
    To investigate how well short-term progression rates can predict long-term visual field outcomes in patients with glaucoma.
  65. pmc Driving cessation and driving limitation in glaucoma: the Salisbury Eye Evaluation Project
    Pradeep Y Ramulu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    Ophthalmology 116:1846-53. 2009
    To determine if glaucoma is associated with driving limitation or cessation.
  66. pmc Mechanisms of retinal ganglion cell injury and defense in glaucoma
    Juan Qu
    Department of Ophthalmology, Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Exp Eye Res 91:48-53. 2010
    b>Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness...
  67. ncbi Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development
    R S Smith
    The Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 9:1021-32. 2000
    ..anomaly (ARA), variably associate with harmfully elevated intraocular pressure (IOP), which causes glaucoma. Clinically observed dysgenesis does not correlate with IOP, however, and the etiology of glaucoma development is ..
  68. pmc A combined index of structure and function for staging glaucomatous damage
    Felipe A Medeiros
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, CA 92093 0946, USA
    Arch Ophthalmol 130:1107-16. 2012
    ..To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage...
  69. doi Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida, USA
    Ophthalmology 119:1151-8. 2012
    ..cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH)..
  70. pmc Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma
    A K Cybulska-Heinrich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 18:390-402. 2012
    ..One such disease is glaucoma.Glaucoma leads to the loss of retinal ganglion cells and their axons but also to tissue remodelling which ..
  71. pmc Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma
    H L Rao
    VST Glaucoma Center, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India
    Eye (Lond) 26:133-9. 2012
    To compare the diagnostic abilities of peripapillary retinal nerve fiber layer (RNFL) and macular inner retina (MIR) measurements by spectral domain optical coherence tomography (SD-OCT) in Indian eyes early glaucoma.
  72. pmc Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Florida, USA
    Invest Ophthalmol Vis Sci 52:8323-9. 2011
    ..To demonstrate the capability of SD-OCT to measure macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness and to assess its reproducibility in glaucomatous eyes...
  73. pmc Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors
    E M McElnea
    1Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland
    Mol Vis 17:1182-91. 2011
    Oxidative stress is implicit in the pathological changes associated with glaucoma. The purpose of this study was to compare levels of oxidative stress in glial fibrillary acid-negative protein (GFAP) lamina cribrosa (LC) cells obtained ..
  74. doi Resident-performed Ex-PRESS shunt implantation versus trabeculectomy
    Michael I Seider
    Department of Ophthalmology, University of California, San Francisco, CA, USA
    J Glaucoma 21:469-74. 2012
    ..To compare outcomes between resident-performed trabeculectomy and Ex-PRESS shunt implantation...
  75. doi Neuroprotection in glaucoma: recent and future directions
    Helen V Danesh-Meyer
    Department of Ophthalmology, University of Auckland, Auckland, New Zealand
    Curr Opin Ophthalmol 22:78-86. 2011
    The concept of neuroprotective therapy for glaucoma is that damage to retinal ganglion cells (RGCs) may be prevented by intervening in neuronal death pathways...
  76. pmc Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
    Martin B Wax
    Ophthalmology Discovery Research, Alcon Corporation, Fort Worth, Texas 76134, USA
    J Neurosci 28:12085-96. 2008
    ..b>Glaucoma traditionally is associated with elevated intraocular pressure, but often occurs or may progress with intraocular ..
  77. doi Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients
    Anthony P Wells
    Capital Eye Specialists, Wellington, New Zealand
    Invest Ophthalmol Vis Sci 49:3262-8. 2008
    ..To investigate relationships between acute intraocular pressure (IOP)-induced optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous and nonglaucomatous human eyes...
  78. doi A novel method for the induction of experimental glaucoma using magnetic microspheres
    Paulina A Samsel
    School of Optometry, Cardiff University, Cardiff, United Kingdom
    Invest Ophthalmol Vis Sci 52:1671-5. 2011
    The development of a method for the sustained elevation of intraocular pressure in experimental glaucoma based on the anterior chamber injection of paramagnetic microbeads.
  79. ncbi Glaucoma in Zulus: a population-based cross-sectional survey in a rural district in South Africa
    Alan P Rotchford
    International Centre for Eye Health, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England
    Arch Ophthalmol 120:471-8. 2002
    To determine the prevalence and the main types of glaucoma in a representative adult population in rural Zululand, and to describe the distribution of glaucoma-related variables in healthy subjects and those with glaucoma.
  80. doi The role of blood pressure in glaucoma
    Zheng He
    Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia
    Clin Exp Optom 94:133-49. 2011
    Although intraocular pressure (IOP) remains an important risk factor for glaucoma, it is clear that other factors can also influence disease development and progression...
  81. pmc Interventions improve poor adherence with once daily glaucoma medications in electronically monitored patients
    Constance O Okeke
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ophthalmology 116:2286-93. 2009
    To investigate the impact of an intervention program to improve adherence with topical, once daily therapy for glaucoma.
  82. doi Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma
    Y Munemasa
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Gene Ther 16:17-25. 2009
    ..Trx2) which play critical roles in the regulation of oxidative stress on retinal ganglion cells (RGCs) in a rat glaucoma model...
  83. pmc Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness
    G Vizzeri
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Br J Ophthalmol 93:775-81. 2009
    ..To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements...
  84. pmc Endothelin, astrocytes and glaucoma
    Ganesh Prasanna
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Exp Eye Res 93:170-7. 2011
    It has become increasingly clear that astrocytes may play an important role in the genesis of glaucoma. Astrogliosis occurs in response to ocular stress or the presence of noxious stimuli...
  85. ncbi Risk factors for progression of visual field abnormalities in normal-tension glaucoma
    S Drance
    Bascom Palmer Eye Institue, Miami, FL 33101-6880, USA
    Am J Ophthalmol 131:699-708. 2001
    ..uncover risk factors for the highly variable individual rates of progression in cases of untreated normal-tension glaucoma. METHODS: Visual field data were assembled from 160 subjects (160 eyes) enrolled in the collaborative normal-..
  86. ncbi Modification of ocular defects in mouse developmental glaucoma models by tyrosinase
    Richard T Libby
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Science 299:1578-81. 2003
    ..cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a common cause of human primary congenital glaucoma (PCG)...
  87. pmc The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population
    Muhammad Imran Khan
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 16:2146-52. 2010
    The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients.
  88. doi Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model
    Yasunari Munemasa
    Department Ophthalmology, St Marianna University School of Medicine, Kawasaki, Japan
    J Neurochem 115:1508-19. 2010
    ..of mitochondrial membrane permeability and apoptosis-inducing factor (AIF) translocation in a rat experimental glaucoma model...
  89. ncbi Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma
    Hiu Chi Chan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Exp Neurol 203:269-73. 2007
    b>Glaucoma is one of the major neurological disorders in eye leading to irreversible blindness in elderly...
  90. pmc Exploring eye movements in patients with glaucoma when viewing a driving scene
    David P Crabb
    Department of Optometry and Visual Science, City University London, London, United Kingdom
    PLoS ONE 5:e9710. 2010
    b>Glaucoma is a progressive eye disease and a leading cause of visual disability...
  91. pmc Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma
    John C Morrison
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Ceres, 3375 SW Terwilliger Bvld, Portland, OR 97239, USA
    Exp Eye Res 93:156-64. 2011
    ..Using these tools, major insights have been gained into ONH and the retinal cellular responses to elevated IOP that, in time, can be applied to the primate model and, ultimately, human glaucoma.
  92. ncbi Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes
    Donald L Budenz
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:2440-3. 2005
    ..To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes...
  93. pmc Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
    Gareth R Howell
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 122:1246-61. 2012
    b>Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs)...
  94. ncbi Refractive errors, intraocular pressure, and glaucoma in a white population
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 110:211-7. 2003
    To examine the relation of refractive errors to glaucoma and intraocular pressure (IOP) in a defined white population.
  95. ncbi Spectral content of the intraocular pressure pulse wave: glaucoma patients versus normal subjects
    David W Evans
    Department of Optometry, School of Optometry, University of Alabama at Birmingham, Alabama, USA
    Graefes Arch Clin Exp Ophthalmol 240:475-80. 2002
    ..The purpose of this study, therefore, was to determine whether such a technique is applicable to the IOP pulse and to investigate whether it was superior at differentiating diseased from healthy eyes...
  96. pmc Early microglia activation in a mouse model of chronic glaucoma
    Alejandra Bosco
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA
    J Comp Neurol 519:599-620. 2011
    ..Activated microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in its pathophysiology remains unresolved...
  97. ncbi Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
    ..Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases...
  98. ncbi Müller cell response to laser-induced increase in intraocular pressure in rats
    Elizabeth WoldeMussie
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Glia 47:109-19. 2004
    ..The increase in GLAST along with minimum change in GS indicates a disturbance in glutamate homeostasis...
  99. ncbi The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
    Claude F Burgoyne
    LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
    Prog Retin Eye Res 24:39-73. 2005
    ....
  100. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..gamma-irradiation accompanied with syngeneic bone marrow transfer can confer complete protection against glaucoma in a mouse model. Because bone marrow genotype was unaltered by this procedure, it was not the causative agent...
  101. ncbi Corticosteroid-induced glaucoma: a review of the literature
    J P Kersey
    Department of Ophthalmology, Norfolk and Norwich University Hospital, Norwich, Norfolk NR4 7UY, UK
    Eye (Lond) 20:407-16. 2006
    ..The purpose of this review is to describe the risk factors for developing corticosteroid-induced glaucoma, to discuss the underlying mechanisms and genetics of the condition and to present management options.

Research Grants78

  1. Promoters for Glaucoma Gene Therapy
    CURTIS BRANDT; Fiscal Year: 2007
    b>Glaucoma, a progressive optic neuropathy usually involving elevated intraocular pressure, is a leading cause of blindness worldwide. The incidence increases with age and is high among certain ethnic groups...
  2. OCULAR ACTIONS OF ENDOTHELINS
    Thomas Yorio; Fiscal Year: 2005
    DESCRIPTION (From the Applicant's Abstract): Glaucoma is a leading cause of blindness in the U.S. and worldwide that occurs as a result of a loss in retinal ganglion cells and a progressive optic neuropathy...
  3. Depth Maps From Stereo Images of the Optic Disc-Phase II
    GILBERTO ZAMORA; Fiscal Year: 2006
    DESCRIPTION: It is estimated that 3 million Americans have glaucoma,and 67 million peopleworldwidewill have glaucomaby2005. At least half do not know they have it because glaucoma usually has no symptoms in the early stages...
  4. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    Primary open angle glaucoma (POAG) is one of the four major causes of blindness and visual disability. Two million people in the United States have glaucoma; 100,000 of them are blind...
  5. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Disease-causing mutations are associated with many eye diseases, including glaucoma, cataracts, strabismus, corneal dystrophies and a number of forms of retinal degenerations...
  6. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Disease-causing mutations are associated with many eye diseases, including glaucoma, cataracts, strabismus, corneal dystrophies and a number of forms of retinal degenerations...
  7. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is a chronic neurodegenerative disease that makes up one of the leading causes of blindness worldwide...
  8. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  9. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is a leading cause of blindness in the United States...
  10. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    Project Summary Glaucoma is an optic neuropathy characterized by degeneration of the optic nerve, cupping of the optic disc and apoptosis of retinal ganglion cells, ultimately resulting in blindness...
  11. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Glaucoma can be defined as progressive optic neuropathy with structural damage of the optic nerve (ON) head and selective death of retinal ganglion cells (RGC)...
  12. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  13. Prevention of Retinal Degeneration by Crystallins in Experimental Uveitis
    Narsing A Rao; Fiscal Year: 2011
    ..implicated in various blinding diseases, including age-related macular degeneration, retinal vein occlusion, and glaucoma. PUBLIC HEALTH RELEVANCE AlphaA crystallin is a unique protein present in the eye and other tissues...
  14. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT Glaucoma, the leading cause of irreversible blindness in the United States and worldwide, remains a major global public health concern...
  15. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2009
    ..Most are incurable or result in permanent visual loss by the time of diagnosis. An exception is glaucoma, the most common optic neuropathy, where the most important risk factor is elevated intraocular pressure...
  16. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    ..by applicant): New approaches to lower intraocular pressure, a significant risk factor for the progression of glaucoma, will be investigated...
  17. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2013
    ..and related dementias, amyotrophic lateral sclerosis and related neuronopathies, Parkinson's disease and glaucoma. PUBLIC HEALTH RELEVANCE: This project addresses how neurons assemble an internal supporting framework enabling ..
  18. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..cell transplants into the eye to reduce the progression of damage and visual loss in an inducible rodent model of glaucoma (chronic ocular hypertension)...
  19. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..Reactive glia are present in many eye diseases, including glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and retinopathy of prematurity...
  20. Forward Genetics to Identify Complex Gene Interactions Involved in Glaucoma
    Elena V Semina; Fiscal Year: 2010
    ..we will identify complex genetic interactions that contribute to phenotypes associated with primary open angle glaucoma. The glaucomas are a group of vision impairing diseases characterized by retinal ganglion cell death, and ..
  21. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..as well potentially involved in a variety of disorders including sleep disorders, seasonal affected disorders and glaucoma, the NIH has highlighted melanopsin as a priority for future research...
  22. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is an irreversible blinding disease that will affect over 79 million people worldwide by the year 2020...
  23. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..tools developed in this study will also have application in developing therapies for diabetic retinopathy, age related macular degeneration, glaucoma etc., that are collectively the most common causes of blindness in the United States.
  24. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma, one of the world's leading causes of visual impairment and blindness, is characterized by excavation of the optic nerve head and selective apoptotic loss of retinal ganglion cells (RGCs)..
  25. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
    ..cells in the trabecular meshwork contribute to the pathogenesis of this tissue in aging and primary open angle glaucoma. The specific hypothesis to be tested is that down-regulation of the microRNAs miR-155, mir-204 and mir-29 in ..
  26. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..of the cells in the eye underlies various pathologies including cataracts, age related macular degeneration and glaucoma, currently there are no approved therapeutic agents for treating cellular degeneration associated with these ..
  27. Role of trabecular meshwork contractility in modulating outflow resistance
    CHEE HIAN TAN; Fiscal Year: 2013
    ..investigator (PI) with the experience and skills necessary to become an independent investigator in the field of glaucoma research. The PI's Doctoral and Postdoctoral research were in the field of glaucoma...
  28. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Myopia is associated with retinal detachment, macular degeneration, cataract and glaucoma, with high myopia being one of the leading causes of blindness...
  29. Protein Acetylation in Glaucomatous Optic Neuropathy
    Craig E Crosson; Fiscal Year: 2013
    The long-term goals of this project are to identify the events responsible for optic neuropathy that develops in glaucoma, and to identify strategies that prevent or delay this vision loss...
  30. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..the promise of applying this newly defined dual pathway inhibition to prevalent conditions such as AMD and glaucoma, the challenges of sustained therapeutic delivery to the back of the eye, and the design of clinical trials for ..
  31. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..vascular risk factors in explaining why individuals of African descent (AD) are disproportionately affected by glaucoma compared to individuals of European descent (ED)...
  32. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is a leading cause of blindness in the United States, and the second leading cause worldwide...
  33. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Understanding the pathogenesis of glaucoma, the second leading cause of blindness, is an important goal of vision research...
  34. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..Finally, we will examine genetic determinants of AMD and Glaucoma in this racial/ethnic group...
  35. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..Elevated IOP is the only treatable risk-factor for glaucoma. Unfortunately, the key molecules involved in outflow resistance and IOP control are unknown...
  36. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..HHcy is implicated in retinal vascular occlusive disease, optic neuropathies (e.g. pseudoexfoliation glaucoma), macular degeneration, and diabetic retinopathy...
  37. Imaging retinal astrocytes, ganglion cells and axonal transport in vivo
    Brad Fortune; Fiscal Year: 2012
    ..are disrupted during the earliest stages of response to experimental injuries such as axotomy and experimental glaucoma. This disruption is significant because microtubules are the "tracks" upon which axonal transport is driven...
  38. Cell Communication of the Vertebrate Retina
    ROBERT FRANCIS MILLER; Fiscal Year: 2012
    ..This property of NMDA receptors can be additive to the ganglion cell risk factors found in conditions such as glaucoma, ischemia, injury or diabetic retinopathy...
  39. BIOGENESIS OF MELANOSOMES
    Seth J Orlow; Fiscal Year: 2013
    ..in autoimmune diseases such as vitiligo, and in melanoma, and may be a modifier locus for primary congenital glaucoma and macular degeneration in X-linked retinoschisis...
  40. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2012
    DESCRIPTION (provided by principal investigator): Glaucoma remains a major blinding disease affecting over 66 million persons worldwide...
  41. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..hypertension, angina, cardiovascular disease, stroke, arthritis, gall bladder disease, vision (cataracts, glaucoma, macular degeneration), heart rhythm abnormalities, kidney stones, and cancer. Aim 2...
  42. Characterization of RGC death susceptibility alleles
    Robert W Nickells; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is a chronic blinding neurodegenerative disease characterized by the progressive loss of retinal ganglion cells and degeneration of the optic nerve...
  43. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is a leading cause of preventable blindness, particularly among persons of African and Latino descent...
  44. Immune-mediated Neuroprotection of Retinal Ganglion Cells
    DALE SANNES GREGERSON; Fiscal Year: 2012
    ..to promote neuroprotection in chronic diseases of the eye that have enormous health impacts on the retina (glaucoma, macular degeneration, diabetes, etc.)...
  45. Characterization of purified myocilin: glaucoma as a protein misfolding disease
    Raquel L Lieberman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma, the leading cause of blindness in the world, has no direct treatment...
  46. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..Further, this product will offer a new view to the irido-corneal angle for assessment of narrow angle glaucoma. PUBLIC HEALTH RELEVANCE: Dry Eye disease is an affliction that impacts as many much as 20% of the U.S...
  47. Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Rebecca M Sappington; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glaucoma is an age-related disease that blinds through the degeneration of retinal ganglion cells (RGCs) and their axons in the optic nerve...
  48. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..Other therapeutic possibilities include pain management (chronic pain), glaucoma (lowering the intraocular pressure), and anxiety...
  49. GENETIC DISSECTION OF PHOTOTRANSDUCTION
    Baruch Minke; Fiscal Year: 2011
    ..insights on the involvement of pathological activation of mammalian TRP channels in retinal degeneration and glaucoma. PUBLIC HEALTH RELEVANCE: A powerful approach to identify potentially important proteins for mammalian retinal ..
  50. Genetic Basis of Nanophthalmos and Human Ocular Biometry
    Olof H Sundin; Fiscal Year: 2010
    ..As adults, nanophthalmos patients often develop major secondary complications, including angle closure glaucoma, macular edema and exudative retinal detachment...
  51. STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGE
    John C Morrison; Fiscal Year: 2013
    ..cellular mechanisms of axonal injury from elevated intraocular pressure (IOP) is essential for developing glaucoma treatments that will protect the optic nerve...
  52. The Role of Complement System in Glaucoma
    Markus H Kuehn; Fiscal Year: 2012
    b>Glaucoma is a leading cause of blindness worldwide and continues to pose a clinical challenge...
  53. Easy-to-Use, Low-Cost, Handheld Retinal Camera for Screening for Diabetic Retinop
    RANDAL CHINNOCK; Fiscal Year: 2009
    ..to be used as a screening or diagnostic tool for diabetic retinopathy, hypertensive retinopathy, CMV retinitis, glaucoma, detached retina, and other abnormalities of the retina...
  54. Autophagic Lysosomal Pathway and Glaucoma
    PALOMA LITON; Fiscal Year: 2013
    ..outflow pathway associated with elevated intraocular pressure and therefore, increased risk of developing glaucoma, an age-related disease affecting more than 70 million people world wide still remains obscure...
  55. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2013
    ..its associated ocular morbidities of retinal detachment, macular choroidal degeneration, premature cataract, and glaucoma. Ample evidence documents the heritability of the non-syndromic forms of this condition, especially for high-..
  56. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2013
    Primary open-angle glaucoma (POAG) is an intraocular pressure (IOP)-dependent, slowly progressive optic neuropathy that ultimately leads to blindness...
  57. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    HARRY ALAN QUIGLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project seeks to develop new treatments for glaucoma based on the response of ocular tissues to the effects of intraocular pressure (IOP) related stress...
  58. Lipidomic profile of endocannabinoids from neuronal cells
    VINCENT JO DAVISSON; Fiscal Year: 2010
    ..manipulation of this system has potentially therapeutic effects in such conditions as convulsions, glaucoma, movement disorders, anxiety, obesity, and multiple sclerosis...
  59. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
    DESCRIPTION: This project seeks ways to enhance aqueous humor outflow for glaucoma therapy...
  60. Compartmentalized neurodegeneration of retinal ganglion cells in glaucoma
    Yvonne Ou; Fiscal Year: 2013
    ..an independent clinical scientist advancing our understanding of the neurodegenerative mechanisms underlying glaucoma and improving its treatment. Dr...
  61. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..axial length of the eye significantly raises the risk of retinal detachment, choroidal neovascularization and glaucoma, making myopia the 7th leading cause of blindness in the U.S...
  62. Mitochondrial dysfunction in glaucomatous optic neuropathy
    Won Kyu Ju; Fiscal Year: 2013
    ABSTRACT Glaucoma is the leading cause of irreversible blindness and affects more than 66 million people worldwide...
  63. NEURITIN:novel RGC neurotrophic factor and potential target for glaucoma therapy
    Donald J Zack; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Glaucoma is the second leading cause of blindness in the United States...
  64. Detection of Glaucoma Progression with Macular OCT Imaging
    Kouros Nouri-Mahdavi; Fiscal Year: 2013
    ..by applicant): This application is a formal request for a career development award (K23) for an academic glaucoma specialist with a serious interest in the role of imaging in glaucoma using optical coherence tomography (OCT)...
  65. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary open angle glaucoma (POAG), the most common form of glaucoma, is usually accompanied by elevated intraocular pressure (IOP) due to failure of the trabecular meshwork (TM) to maintain normal ..
  66. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..program to develop a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP)...
  67. Telemetric Implantable Intraocular Pressure Sensor Syste
    LAWRENCE WAN; Fiscal Year: 2003
    ..developing a new and unique miniature ophthalmic lOP sensor, to be retrofitted into the cannula of a conventional Glaucoma Drainage Device and surgically implanted under the sclera for the purpose of continuous measurement and ..
  68. Sustained Drug Release for Antifibrosis
    Weiliam Chen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Glaucoma is the second leading cause of irreversible vision losss in the United States...
  69. A Potential Zebrafish Model of Glaucoma by Genetic Ablation and Modification of t
    Xinping Zhao; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Glaucoma is a group of heterogeneous disorders characterized by optic neuropathies, dropout of retinal ganglion cells, and visual field loss...
  70. 5-FLUOROURACIL & GLAUCOMA FILTERING SURGERY
    Dale Heuer; Fiscal Year: 1992
    ..if postoperative subconjunctival injections of 5-fluorouracil (5- FU) would increase the success rate of glaucoma filtering surgery in patients with poor prognoses...
  71. DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIAL
    M Leske; Fiscal Year: 2004
    The Early Manifest Glaucoma Trial (EMGT) is the first large randomized, controlled clinical trial to evaluate the effect of lowering the intraocular pressure (IOP) on the progression of newly detected open-angle glaucoma...
  72. Amniotic Membrane Patch Graft to Cover Glaucoma Drainage Tube
    HOSAM EL SHEHA; Fiscal Year: 2009
    b>Glaucoma drainage devices (GDDs) have widely been used in the treatment of high risk refractory glaucoma...
  73. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    DESCRIPTION: Glaucoma is a major cause of blindness. It involves death of retinal ganglion cells and degeneration of the optic nerve. High intraocular pressure (IOP) is frequently associated with glaucoma...
  74. Genome-Wide Targeted Gene Resequencing in Glaucoma
    THERESA GAASTERLAND; Fiscal Year: 2010
    ..Primary open angle glaucoma (POAG) is the most frequent form of glaucoma in the United States and a leading cause of irreversible blindness ..
  75. Autoregulation and Systemic Blood Pressure: A New View of Normal Tension Glaucoma
    Mary Charlson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The dominant hypothesis about normal tension glaucoma is that progressive visual field loss in normal tension glaucoma is a result of elevated intra-ocular pressures...
  76. OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmology
    Linda Zangwill; Fiscal Year: 2009
    ..CSLO) data from two large randomized trials, the Ocular Hypertension Treatment Study (OHTS) and the European Glaucoma Prevention Study (EGPS), to improve our ability to predict the development of primary open angle glaucoma (POAG) ..
  77. Ocular Insert for Non-Invasive Sustained Drug Delivery for the Treatment of Glauc
    CHARLES DANIEL contact LEAHY; Fiscal Year: 2010
    ..periods on one specific product - a topical ophthalmic drug delivery device (TODDD") delivering timolol, to treat glaucoma. Timolol is one of the most commonly used glaucoma drugs and is not patent protected...
  78. DEVELOPMENT OF A NOVEL GLAUCOMA IMPLANT
    Abdul Ahmed; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) Glaucoma is the leading cause of blindness in the world. Glaucoma is a complex disease with many underlying etiologies...