Genomes and Genes
ocular motility disorders
Summary: Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Publications202 found, 100 shown here
- Recent progress in understanding congenital cranial dysinnervation disordersDarren T Oystreck
Department of Ophthalmology, College of Medicine, King Saud University, and King Abdulaziz University Hospital, Riyadh, Saudi Arabia
J Neuroophthalmol 31:69-77. 2011..This report provides an update 8 years after that original report...
- Validity of the convergence insufficiency symptom survey: a confirmatory studyMichael Rouse
Southern California College of Optometry, Fullerton, California 92831, USA
Optom Vis Sci 86:357-63. 2009....
- Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson's diseaseElmar H Pinkhardt
Department of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 256:1438-46. 2009..The differences in pursuit tracking between PD and MSA were large enough to warrant their use as ancillary diagnostic criteria for the distinction between these disorders...
- Near point of convergence norms measured in elementary school childrenWillis C Maples
Southern College of Optometry, Memphis, Tennessee 38104, USA
Optom Vis Sci 84:224-8. 2007..Convergence insufficiency (CI) is the most prevalent of binocular dysfunctions. A prime finding in the diagnosis of CI is the near point of convergence (NPC)...
- Eye tracking dysfunction in schizophrenia: characterization and pathophysiologyDeborah L Levy
Psychology Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Top Behav Neurosci 4:311-47. 2010..Broader application of localizing behavioral paradigms in patient and family studies would be advantageous for refining the eye tracking phenotype for genetic studies...
- Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodiesUrs P Mosimann
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Brain 128:1267-76. 2005..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
- Physiology and pathology of eye-head coordinationFrank Antony Proudlock
Ophthalmology Group, RKCSB, Leicester Royal Infirmary, University Hospitals of Leicester, University of Leicester, Leicester, UK
Prog Retin Eye Res 26:486-515. 2007..We provide evidence for this based on changes in eye-head coordination dependant on the context and expectation of presented visual stimuli, as well as from changes in eye-head coordination caused by frontal lobe dysfunction...
- Smooth pursuit and visual scanpaths: Independence of two candidate oculomotor risk markers for schizophreniaSara A Beedie
School of Psychology, College of Life Sciences and Medicine, William Guild Building, University of Aberdeen, King s College, Aberdeen, UK
World J Biol Psychiatry 13:200-10. 2012..We have examined co-occurrence of ETD and scanpath disturbance in individuals with schizophrenia and healthy volunteers...
- Reliability of binocular vision measurements used in the classification of convergence insufficiencyMichael W Rouse
Southern California College of Optometry, Fullerton 92831, USA
Optom Vis Sci 79:254-64. 2002..To evaluate the reliability of binocular vision measurements used in the classification of convergence insufficiency...
- Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosisM J van Tricht
Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
Brain Cogn 73:215-21. 2010..The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system...
- Schizophrenia-related neuregulin-1 single-nucleotide polymorphisms lead to deficient smooth eye pursuit in a large sample of young menNikolaos Smyrnis
Psychiatry Department, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 72 Vas Sofias Avenue, Athens, Greece
Schizophr Bull 37:822-31. 2011..NRG1 genotype variations were related to smooth eye pursuit variations both at the SNP level and at the haplotype level adding to the validation of this gene as a candidate gene for the disorder...
- Factors associated with base-in prism treatment outcomes for convergence insufficiency in symptomatic presbyopesYi Pang
Illinois College of Optometry, Chicago, Illinois 60616, USA
Clin Exp Optom 95:192-7. 2012..We further determined the factors that predicted CI treatment outcomes...
- Eye tracking performance and the boundaries of the schizophrenia spectrumVivian Mitropoulou
Mount Sinai School of Medicine Dept of Psychiatry, The James J Peters Veterans Affairs Medical Center, and VISN 3 MIRECC, NY, USA
Psychiatry Res 186:18-22. 2011..Indeed, SPD subjects comprise the only group not statistically different from schizophrenic patients in quantitative or qualitative ratings...
- Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracyPhilip J Benson
School of Psychology, King s College, University of Aberdeen, Aberdeen, United Kingdom
Biol Psychiatry 72:716-24. 2012..We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their predictive validity...
- Is persistent ketamine use a valid model of the cognitive and oculomotor deficits in schizophrenia?Celia J A Morgan
Clinical Psychopharmacology Unit, University College London, United Kingdom
Biol Psychiatry 65:1099-102. 2009..In this study, we investigated the effect of persistent recreational ketamine use on tests of episodic and working memory and on oculomotor tasks of smooth pursuit and pro- and antisaccades...
- Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's diseaseAshley J Hood
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
J Neurol Neurosurg Psychiatry 78:565-70. 2007..Previous studies have shown that patients with PD have impaired executive function, including deficits in attention, motor planning and decision making...
- Eye movements in chorea-acanthocytosisLibe Gradstein
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Invest Ophthalmol Vis Sci 46:1979-87. 2005..In contrast to Huntington's disease (for which ChAc has occasionally been mistaken), ocular involvement in ChAc has not been systematically studied...
- (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2Isabelle Iltis
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Brain Res 1358:200-10. 2010..We aimed at assessing the neurochemical profile of the pons, the cerebellar hemisphere and the vermis in patients with FRDA and AOA2 to identify potential biomarkers of these diseases...
- The tell-tale tasks: a review of saccadic research in psychiatric patient populationsDiane C Gooding
Department of Psychology, University of Wisconsin Madison, College of Letters and Sciences, 1202 West Johnson Street, Madison, WI 53706, USA
Brain Cogn 68:371-90. 2008..g. cortical/basal ganglia circuits) that may be implicated in the underlying pathophysiology of several of these disorders. Future directions for research in this growing area are offered...
- Cerebellar ataxia with oculomotor apraxia type 1: clinical and genetic studiesIsabelle Le Ber
Federation de Neurologie, Hôpital de la Salpêtrière AP HP, Paris, France
Brain 126:2761-72. 2003..The frequency of chorea at onset suggests that this diagnosis should also be considered in children with chorea who do not carry the IT15 mutation responsible for Huntington's disease...
- Validity and reliability of the revised convergence insufficiency symptom survey in adultsMichael W Rouse
Southern California College of Optometry, Fullerton, CA, USA
Ophthalmic Physiol Opt 24:384-90. 2004..The CISS was developed to be the primary outcome measure for studies evaluating various treatments for convergence insufficiency (CI)...
- Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafishH A Burgess
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Genes Brain Behav 8:500-11. 2009..Moreover, we show that twitch twice mutants exhibit normal visual acuity but display defects in horizontal eye movements, suggesting a specific and critical role for twitch twice/robo3 in sensory-guided behavior...
- CEP290 mutations are frequently identified in the oculo-renal form of Joubert syndrome-related disordersFrancesco Brancati
IRCCS CSS, Mendel Institute, Viale Regina Margherita 261, 00198, Rome, Italy
Am J Hum Genet 81:104-13. 2007..One patient with mutation displayed complete situs inversus, confirming the clinical and genetic overlap between JSRDs and other ciliopathies...
- Identification of the first AHI1 gene mutations in nephronophthisis-associated Joubert syndromeBoris Utsch
Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, USA
Pediatr Nephrol 21:32-5. 2006..One patient had the association of JBTS and NPHP with chronic renal failure. This is the first report of AHI1 mutations causing JBTS associated with NPHP, confirming the clinical and genetic heterogeneity of NPHP...
- Infantile Parkinsonism-dystonia and elevated dopamine metabolites in CSFB E Assmann
Department of General Pediatrics, University Children s Hospital, Duesseldorf, Germany
Neurology 62:1872-4. 2004..Pyramidal tract signs also emerged in the course of the disease in two patients. This combination of symptoms and biochemical findings suggests a unique pathogenic mechanism...
- Diagnostic yield of the evaluation of isolated third nerve palsy in adultsKara L Schultz
Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Can J Ophthalmol 42:110-5. 2007..We aim to define diagnostic yield for neuroimaging of third nerve palsy (TNP) by degree of internal and external dysfunction using previously published imaging guidelines...
- Neuro-ophthalmologic manifestations of paraneoplastic syndromesMelissa W Ko
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Neuroophthalmol 28:58-68. 2008..Most of these disorders are related to immunologic mechanisms presumably triggered by the neoplastic expression of neuronal proteins. Accurate recognition is essential to appropriate management...
- Saccadic burst cell membrane dysfunction is responsible for saccadic oscillationsAasef G Shaikh
Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
J Neuroophthalmol 28:329-36. 2008..Our simulations suggest that alterations in membrane properties that lead to an increase in PIR, a reduction in external glycinergic inhibition, or both can cause saccadic oscillations...
- Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3T M Bosley
Neuro Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
Neurology 64:1196-203. 2005....
- Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlatesA M Wong
Division of Neurology, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
J Neurol Sci 189:71-81. 2001..Malfunction of Purkinje cells in the dorsal vermis, which inhibit the FOR, may cause opsoclonus by disinhibiting it...
- Allelic ROBO3 heterogeneity in Tunisian patients with horizontal gaze palsy with progressive scoliosisRim Amouri
Laboratoire de Neurobiologie Moleculaire et de Neuropathologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia
J Mol Neurosci 39:337-41. 2009..This study extends the molecular spectrum of the ROBO3 gene and the geographic origin of patients with ROBO3 gene mutations, and underlines the homogeneity of the motor ocular syndrome whatever type of mutation is encountered...
- CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290Nicholas T Gorden
Division of Genetics and Developmental Medicine, Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Hum Genet 83:559-71. 2008..These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies...
- Neuropathology of Joubert syndromeA T Yachnis
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine and UF Brain Institute, Gainesville 32610 0275, USA
J Child Neurol 14:655-9; discussion 669-72. 1999..The latter could explain certain clinical features of the syndrome, including episodic hyperpnea and oculomotor apraxia...
- Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3W M Chan
J Med Genet 43:e11. 2006..We previously reported that HGPPS patients from consanguineous pedigrees harbour homozygous mutations in the axon guidance molecule ROBO3...
- Synergistic convergence in congenital extraocular muscle misinnervationChristina Pieh
Arch Ophthalmol 126:574-6. 2008
- Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmusK Hufner
Department of Neurology, Klinikum Grosshadern, Neurologisches Forschungshaus, Munich, Germany
Neurology 69:1128-35. 2007..Forty percent of patients with DBN are classified as having idiopathic DBN, because no underlying pathology can be demonstrated by conventional MRI or laboratory tests...
- Analysis of the CHN1 gene in patients with various types of congenital ocular motility disordersAlexander E Volk
Institute of Human Genetics, University Hospital of Cologne, Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 248:1351-7. 2010..We screened for CHN1 mutations in patients with various congenital ocular motility disorders.
- Therapeutic considerations for eye movement disordersA Straube
Department of Neurology, University of Munich, Munich, Germany
Dev Ophthalmol 40:175-92. 2007..Finally, anticonvulsants like carbamazepine are the drugs of choice for disorders involving a nerve-blood vessel contact that induces symptoms of vestibular paroxysmia or superior oblique myokymia...
- Bilateral synergistic convergence associated with homozygous ROB03 mutation (p.Pro771Leu)Arif O Khan
Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
Ophthalmology 115:2262-5. 2008..To document the phenotype and determine the genotype of a child with synergistic convergence...
- Smooth pursuit in patients with downbeat nystagmusStefan Glasauer
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilian University, Munich, Germany
Ann N Y Acad Sci 1039:532-5. 2005....
- Oculomotility disorders arising from disruptions in brainstem motor neuron developmentElizabeth C Engle
Program in Genomics, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Arch Neurol 64:633-7. 2007....
- Cognition, behavior, and development in Joubert syndromeE B Fennell
Department of Clinical and Health Psychology, University of Florida, Gainesville 32610 0165, USA
J Child Neurol 14:592-6. 1999..Future directions of research with this rare disorder are suggested...
- Randomised clinical trial of the effectiveness of base-in prism reading glasses versus placebo reading glasses for symptomatic convergence insufficiency in childrenM Scheiman
Eye Institute, Pennsylvania College of Optometry, 1200 West Godfrey Ave, Philadelphia, PA 19141, USA
Br J Ophthalmol 89:1318-23. 2005..To compare base-in prism reading glasses with placebo reading glasses for the treatment of symptomatic convergence insufficiency (CI) in children aged 9 to <18 years...
- A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disordersAasef G Shaikh
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Brain 130:3020-31. 2007....
- Acquired Pseudo-Brown's syndrome immediately following Ahmed valve glaucoma implantD K Coats
Cullen Eye Institute, Baylor College of Medicine, Texas Children s Hospital, Houston 77030, USA
Ophthalmic Surg Lasers 30:396-7. 1999..Implant-orbital disproportion can produce a pseudo-Brown's syndrome. Surgeons are encouraged to perform forced duction testing at the time of glaucoma implant placement to detect and prevent this complication...
- A randomized clinical trial of treatments for convergence insufficiency in childrenMitchell Scheiman
Eye Institute, Pennsylvania College of Optometry, Philadelphia 19141, USA
Arch Ophthalmol 123:14-24. 2005..To compare vision therapy/orthoptics, pencil push-ups, and placebo vision therapy/orthoptics as treatments for symptomatic convergence insufficiency in children 9 to 18 years of age...
- A survey of treatment modalities for convergence insufficiencyMitchell Scheiman
Pennsylvania College of Optometry, Philadelphia 19141, USA
Optom Vis Sci 79:151-7. 2002..The purpose of this study was to investigate the care process for Cl by surveying eyecare professionals regarding the most common treatment modalities used by both optometrists and ophthalmologists across the United States...
- Joubert syndrome with associated corpus callosum agenesisN Zamponi
Pediatric Neurology Department, Children s Hospital G Salesi, Ancona, Italy
Eur J Paediatr Neurol 6:63-6. 2002..Nevertheless, the hypothesis of a developmental abnormality of midline structures extended to the supratentorial compartment is rather attractive...
- The effectiveness of pencil pushups treatment for convergence insufficiency: a pilot studyMichael Gallaway
Pennsylvania College of Optometry, Philadelphia 19141 3322, USA
Optom Vis Sci 79:265-7. 2002..To study the effectiveness of pencil pushups treatment (PPT) for the treatment of convergence insufficiency in a clinical situation...
- Pontine warning syndromeGustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Ste 931, Toronto ONM5C1R6, Canada
Arch Neurol 65:1375-7. 2008..Little is known about stroke mechanisms in patients with fluctuating symptoms and the role of branch atherosclerotic disease...
- Molar tooth sign in fetal brain magnetic resonance imaging leading to the prenatal diagnosis of Joubert syndrome and related disordersJoel Fluss
Division of Pediatric Neurology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
J Child Neurol 21:320-4. 2006..We report a case of Joubert syndrome diagnosed prenatally using fetal MRI. We also discuss the etiology of Joubert syndrome in view of the recent genetic advances and murine models of cerebellar dysgenesis...
- Eye movement abnormalities in Joubert syndromeAvery H Weiss
Division of Ophthalmology, Children s Hospital and Regional Medical Center, Seattle, Washington 98115, USA
Invest Ophthalmol Vis Sci 50:4669-77. 2009..The goal of the study was to quantify the eye movement abnormalities that occur in Joubert syndrome...
- Clinical features and revised diagnostic criteria in Joubert syndromeB L Maria
Department of Pediatrics, University of Florida, Gainesville, USA
J Child Neurol 14:583-90; discussion 590-1. 1999..We propose a revision in diagnostic criteria for Joubert syndrome...
- Molar tooth sign in Joubert syndrome: clinical, radiologic, and pathologic significanceB L Maria
Department of Pediatrics, University of Florida, Gainesville, USA
J Child Neurol 14:368-76. 1999..A better understanding of the clinical, radiologic, and pathologic features of Joubert syndrome should help uncover the genetic basis for the syndrome...
- Functional MRI, DTI and neurophysiology in horizontal gaze palsy with progressive scoliosisSven Haller
Institute of Radiology, Department of Neuroradiology, University Hospital Basel, Basel, Switzerland
Neuroradiology 50:453-9. 2008..This rare disease is of particular interest because the absence, or at least reduction, of crossing of the ascending lemniscal and descending corticospinal tracts in the medulla predicts abnormal ipsilateral sensory and motor systems...
- Disruption of smooth pursuit eye movements in cirrhosis: relationship to hepatic encephalopathy and its treatmentSara Montagnese
Centre for Hepatology, Department of Medicine, Hampstead Campus, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, United Kingdom
Hepatology 42:772-81. 2005..Treatment status confounds the classification of neuropsychiatric status and should be taken into account when categorizing these patients...
- Are orthoptic exercises an effective treatment for convergence and fusion deficiencies?S Aziz
Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK
Strabismus 14:183-9. 2006..To investigate whether orthoptic exercises are an effective way to influence the near point of convergence, fusion range and asthenopic symptoms...
- Ophthalmic features of Joubert syndromeArif O Khan
Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
Ophthalmology 115:2286-9. 2008..The objective of the current study is to describe the ophthalmic phenotype in a cohort of patients with Joubert syndrome for whom the diagnosis was made using current diagnostic criteria...
- Ocular and oculomotor signs in Joubert syndromeR J Tusa
Bascom Palmer Eye Institute, University of Miami, FL 33101, USA
J Child Neurol 14:621-7. 1999....
- Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testingG Amoiridis
Department of Neurology, University of Crete, PO Box 2208, 71003 Heraklion, Greece
J Neurol Neurosurg Psychiatry 77:1047-53. 2006..Although there is evidence for uncrossed cuneatal and corticospinal tracts in HGPPS, it is unclear whether other central nervous system pathways are involved...
- Self-control during response conflict by human supplementary eye fieldMasud Husain
Imperial College, Division of Neuroscience and Psychological Medicine, Charing Cross Hospital, London W6 8RF, UK
Nat Neurosci 6:117-8. 2003
- Acquired simulated brown syndrome following surgical repair of medial orbital wall fractureJong uk Hwang
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Korean J Ophthalmol 19:80-3. 2005..Postoperatively, the patient was asymptomatic in all diagnostic gaze positions...
- 110th ENMC International Workshop: the congenital cranial dysinnervation disorders (CCDDs). Naarden, The Netherlands, 25-27 October, 2002N J Gutowski
Department of Neurology, Royal Devon and Exeter Hospital, Barrack Road, EX2 5DW, Exeter, UK
Neuromuscul Disord 13:573-8. 2003
- Efficacy of treatment for convergence insufficiency using vision therapyPaul Adler
Ophthalmic Physiol Opt 22:565-71. 2002..The study also evaluates the associated symptoms before and after therapy...
- Ophthalmological findings in Joubert syndromeV Sturm
Department of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
Eye (Lond) 24:222-5. 2010..It has been associated with ocular and oculomotor abnormalities. The aim of our study was to extend the ophthalmic knowledge in JS and to add new findings...
- Retinitis pigmentosa associated with blepharophimosis, blue dot cataract and primary inferior oblique overaction: a new syndrome complex?Vasumathy Vedantham
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
Indian J Ophthalmol 55:150-1. 2007..Computerized search using Medline did not reveal any such previously reported association...
- Smooth pursuit eye movements in 1,087 men: effects of schizotypy, anxiety, and depressionNikolaos Smyrnis
University Mental Health Research Institute, Athens, Greece
Exp Brain Res 179:397-408. 2007....
- Long-term results of silicone expander for moderate and severe Brown syndrome (Brown syndrome "plus")D R Stager
UT Southwestern Medical School and the Pediatric Ophthalmology, PA, Dallas, Texas 75225, USA
J AAPOS 3:328-32. 1999..Dr Kenneth Wright has introduced a procedure of superior oblique muscle tenotomy with a silicone expander to reduce the incidence of overcorrection...
- Hemispheric asymmetry of gaze deviation and relationship to neglect in acute strokeJ M Ringman
Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
Neurology 65:1661-2. 2005..There was no difference in its rate of co-occurrence with neglect between right- and nonright-handed patients...
- Extraocular muscle hypertrophy in myotonia congenitaBradley Wakeman
Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada
J AAPOS 12:294-6. 2008..Esotropia and reduced saccadic velocities have been reported in the dominant form of MC. We report two cases in which orbital magnetic resonance imaging (MRI) imaging showed extraocular muscle hypertrophy...
- Hypoplastic inferior rectus muscle in association with accessory extraocular muscle and globe retractionSeyhan B Ozkan
Department of Ophthalmology, Adnan Menderes University, Aydin, Turkey
J AAPOS 11:488-90. 2007..We present a case with bilateral hypoplasia of the inferior rectus muscle with an accessory extraocular muscle in association with globe retraction and lambda-pattern exodeviation...
- Pearls & Oy-sters: The medial longitudinal fasciculus in ocular motor physiologyT C Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX75235, USA
Neurology 70:e57-67. 2008..To review the role played by the medial longitudinal fasciculus (MLF) in ocular motor physiology and to characterize a number of syndromes that result from lesions in this eloquent brainstem tract system...
- Teaching NeuroImage: one-and-a-half syndromePatricio S Espinosa
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
Neurology 70:e20. 2008
- Selective saccadic palsy after cardiac surgeryScott D Z Eggers
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Neurology 70:318-20. 2008
- Modeling Uhthoff's phenomenon in MS patients with internuclear ophthalmoparesisS L Davis
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX, USA
Neurology 70:1098-106. 2008....
- Reexploration and inferior oblique myectomy temporal to the inferior rectus to treat persistent inferior oblique overactionDavid M Squirrell
Department of Ophthalmology, Royal Hallamshire Hospital, Glossop Road, Sheffield, England
J AAPOS 11:48-51. 2007..We describe the results of reexploration and myectomy of the IO muscle using a standard inferotemporal approach to treat this clinical entity...
- Suppression of saccadic intrusions in hereditary ataxia by memantineA Serra
Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH, USA
Neurology 70:810-2. 2008
- Square wave jerks in children and adolescentsMichael S Salman
Section of Pediatric Neurology, Children s Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Pediatr Neurol 38:16-9. 2008..The prevalence of square wave jerks is high in children and adolescents. This finding may be a feature of the less mature brain, and may reflect an inability to suppress unwanted supranuclear triggers for saccades...
- Wall-eyed bilateral internuclear ophthalmoplegia in a patient with progressive supranuclear palsyMunetaka Ushio
Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Neuroophthalmol 28:93-6. 2008....
- Teaching NeuroImage: Convergence spasm associated with midbrain compression by cerebral aneurysmKonrad P Weber
Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
Neurology 70:e49-50. 2008
- Ocular and oculomotor findings of Joubert syndromeKadircan H Keskinbora
J Pediatr Ophthalmol Strabismus 45:5-6. 2008
- Dissociated palsy of vertical saccades: loss of voluntary and visually guided saccades with preservation of reflexive vestibular quick phasesJi Hoon Kang
Department of Neurology, Cheju National University College of Medicine, Cheju, Republic of Korea
J Neuroophthalmol 28:97-103. 2008....
- Resolution of superior oblique myokymia with memantineSaurabh Jain
Leicester Royal Infirmary, Leicester, United Kingdom
J AAPOS 12:87-8. 2008..After a drug holiday, memantine therapy was initiated resulting in a substantial improvement in her symptoms with far fewer side effects and stability on long-term maintenance therapy...
- Latency of saccades and vergence eye movements in dyslexic childrenMaria Pia Bucci
IRIS, FRE 3154, CNRS, Pôle chirurgie ORL OPH, Hopital Robert Debre, 48 Bld Serurier, 75019 Paris, France
Exp Brain Res 188:1-12. 2008..Difficulties in both voluntary and reflexive control shifts of visual attention from near to far distance in dyslexics could be at the origin of these findings...
- Fibrotic superior oblique and superior rectus muscles with an accessory tissue bandSeyhan B Ozkan
Adnan Menderes University, Department of Ophthalmology, Aydin, Turkey
J AAPOS 11:491-4. 2007..To the best of our knowledge, there is only one partially similar case in the literature with coexistence of congenitally fibrotic superior rectus and superior oblique muscles, and the features of that case differ from those of our case...
- Symptomatic convergence insufficiency. Interview by Leonard B. NelsonKathleen Mahon
J Pediatr Ophthalmol Strabismus 44:202-6. 2007
- Ocular motility and Wilson's disease: a study on 34 patientsI Ingster-Moati
université Paris 7 Diderot, Assistance Publique Hopitaux de Paris, Hopital Necker, Department of Ophthalmology, INSERM, U669, Paris, France
J Neurol Neurosurg Psychiatry 78:1199-201. 2007..The excessive accumulation of copper in the brain induces an extrapyramidal syndrome. Oculomotor abnormalities occur in most extrapyramidal disorders but have rarely been studied in Wilson's disease...
- Taking the temperature of MS with INOR John Leigh
Neurology 70:1063-4. 2008
- Superior oblique tendon incarceration syndromeBurton J Kushner
Department of Ophthalmology and Visual Sciences, University of Wisconsin Hospital and Clinics, 2870 University Ave, Suite 206, Madison, WI 53705, USA
Arch Ophthalmol 125:1070-6. 2007..To describe the clinical features, etiology, and management of superior oblique tendon incarceration syndrome...
- Neural activation associated with corrective saccades during tasks with fixation, pursuit and saccadesSven Haller
Institute of Radiology, Department of Neuroradiology, University Hospital Basel, CH 4031, Basel, Switzerland
Exp Brain Res 184:83-94. 2008....
- Wall-eyed bilateral internuclear ophthalmoplegia from lesions at different levels in the brainstemChien Ming Chen
Section of Neurology, Department of Internal Medicine, Feng Yuan Hospital, Department of Health, Executive Yuan, Taiwan, Republic of China
J Neuroophthalmol 27:9-15. 2007..In a study of the clinical and imaging features of four patients with WEBINO, we found that that three of four lesions involved the midbrain but not necessarily the medial rectus subnuclei...
- Traumatic tear of the inferior rectus muscle treated with inferior oblique anterior transpositionKatyanne Dantas Godeiro
Henry C Witelson Ocular Pathology Laboratory, Department of Ophthalmology, McGill University, Lyman Duff Building, 3775 University Street, Room 216, Montreal, QC, Canada, H3A 2B4
Int Ophthalmol 26:185-9. 2005..To report a case of traumatic tear of the inferior rectus muscle treated with inferior oblique anterior transposition (IOAT)...
- "Inverted Brown pattern": a tight inferior oblique muscle masquerading as a superior oblique muscle underaction--clinical characteristics and surgical managementAhmed Awadein
The Zanvyl Krieger Children s Eye Center at the Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9028, USA
J AAPOS 10:565-72. 2006..To characterize, and evaluate the surgical management of, patients with unilateral deficiency of depression in adduction, suggesting superior oblique muscle underaction, without significant ipsilateral inferior oblique muscle overaction...
- Bilateral acquired Brown syndrome in systemic sclerodermaAcun Gezer
Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Capa 34390, Istanbul, Turkey
J AAPOS 9:195-7. 2005
- Hypoplastic oculomotor nerve and absent abducens nerve in congenital fibrosis syndrome and synergistic divergence with magnetic resonance imagingJae Hyoung Kim
Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Ophthalmology 112:728-32. 2005..The aim of this report was to study the oculomotor nerve and the abducens nerve in 2 such patients with magnetic resonance imaging...
- Extraocular muscle cysticercosis - a clinical challenge to the ophthalmologistsPadmaja Minakshi Sundaram
Department of Neuro Ophthalmology, Medical Research Foundation, Sankara Nethralaya
Orbit 23:255-62. 2004..To report our experience with extraocular myocysticercosis, to highlight the role of ultrasound and orbital computerized tomography (CT) scan in these cases and to discuss the management...
- Medial rectus muscle incarceration in pediatric medial orbital wall trapdoor fracturesT J McCulley
Stanford University School of Medicine, Department of Ophthalmology, Stanford, California 94304 5353, USA
Eur J Ophthalmol 14:330-3. 2004..We describe two cases of orbital trapdoor fractures with medial rectus muscle incarceration...
- Internuclear ophthalmoplegia: causes and long-term follow-up in 65 patientsI Bolaños
Department of Neuroophthalmology, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico
Acta Neurol Scand 110:161-5. 2004..To analyze the causes and long-term clinical outcome of internuclear ophthalmoplegia (INO) in a consecutive series of 65 patients...
- [The effect of weakening inferior oblique muscles on the status of ocular torsion]Guang huan Mai
Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
Zhonghua Yan Ke Za Zhi 40:243-6. 2004..To understand the clinical significance of subjective and objective examination of cyclodeviations and investigate the effect of weakening inferior oblique muscles on the status of ocular torsion...
- Surgical treatment of upgaze palsy in Parinaud's syndromeEdward G Buckley
Pediatric Department, Duke University Eye Center, Durham, NC 27710, USA
J AAPOS 8:249-53. 2004..There are only a few reports on the treatment of this problem in the literature. Patients with Parinaud's syndrome may also have retraction nystagmus and convergence on attempted upgaze that further complicates the treatment...
- FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3Neal Rubinstein; Fiscal Year: 2005..causal relationship between the organization of MyHC isoforms and the behavior of these atypical muscles and to establish a rationale for alternative surgical and pharmacological therapies of ocular motility disorders.
- Motion Perception in SchizophreniaGunvant Thaker; Fiscal Year: 2007..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. [unreadable] [unreadable]..
- Advances in Oculomotor and Vestibular SystemsNeeraj J Gandhi; Fiscal Year: 2010..efforts of clinicians and computational scientists to simulate the pathophysiology of several ocular motility disorders. One uniqueness of the present approach has been to attribute the dysfunction to specific cell membrane ..
- NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLEHENRY KAMINSKI; Fiscal Year: 2000..dystrophy and myasthenia gravis, the results of these investigations will be important for other disorders of extraocular muscle, such as strabismus, genetic ocular motility disorders, congenital myasthenic syndromes, and blepharospasm.
- SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLEJohn Porter; Fiscal Year: 2004..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
- CLINICAL INVESTIGATIONS IN OCULAR MOTILITY DISORDERSNeil Miller; Fiscal Year: 1980..We are also using these models to study central nervous system adaptation in patients with peripheral ocular motor nerve palsies...
- Convergence Insuffiency Treatment TrialMitchell Scheiman; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Liability Markers for Deficit Schizophrenia?L Hong; Fiscal Year: 2004..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
- FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERSGunvant Thaker; Fiscal Year: 2007..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
- RESEARCH TRACK RESIDENCY TRAINING PROGRAMGunvant Thaker; Fiscal Year: 2008..unreadable] [unreadable]..
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesGunvant K Thaker; Fiscal Year: 2010....
- Identifying molecular path of behavioural phenotype in schizophreniaL Hong; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)Joanna C Jen; Fiscal Year: 2010..abstract_text> ..
- International Conference on Episodic Ataxia SyndromesJoanna Jen; Fiscal Year: 2005..abstract_text> ..
- THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPSJoanna Jen; Fiscal Year: 2009..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
- OCULOMOTOR & SPATIAL COGNITION DEFICITS IN SCHIZOPHRENIAJohn Sweeney; Fiscal Year: 2004..Findings will also clarify the diagnostic specificity of regional brain disturbances causing these abnormalities, and the impact of known effective treatments upon them. ..
- MUTATIONS IN CALCIUM CHANNELS CAUSING VERTIGO AND ATAXIAJoanna Jen; Fiscal Year: 2002..The further relevance of this work to the more common basilar migraine and Meniere's syndrome is emphasized by the overlapping symptoms of vertigo and ataxia in the group of patients that we propose to study. ..
- Genetics of Familial Episodic AtaxiaJoanna C Jen; Fiscal Year: 2010..Insights gained from the study will lead to improved diagnosis and treatment of familial episodic ataxia and the more common episodic vertigo syndromes. ..
- Short-term Training Students-Health Professional SchoolsKENNETH CIUFFREDA; Fiscal Year: 2006..Trainees will consist of optometry students who have just completed either their first or second professional years, and have done well academically (3.5 gpa or better). All will have an undergraduate degree, generally in the sciences. ..
- Vestibulocerebellar function in channelopathy mutantsJohn Stahl; Fiscal Year: 2004..Thus, the insights into normal cerebellar function generated by this study should also advance our understanding of mechanisms of heritable neurological disease. ..
- FMRI AND TMS STUDIES OF WORKING MEMORY IN SCHIZOPHRENIADara Manoach; Fiscal Year: 2004..abstract_text> ..
- Outcome Measures in Idiopathic Intracranial HypertensionDeborah Friedman; Fiscal Year: 2008..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
- Study of Carotid Occlusion and Neurocognition (RECON)RANDOLPH MARSHALL; Fiscal Year: 2009....
- PLEIOTROPIC EFFECTS OF GENES LINKED TO SCHIZOPHRENIADeborah L Levy; Fiscal Year: 2010....
- Twin Study of ADHD, CD and Substance AbuseWilliam G Iacono; Fiscal Year: 2010..abstract_text> ..
- Prednisone Ocular Myasthenia Gravis Trial Planning GrantMark Kupersmith; Fiscal Year: 2004....
- PSYCHOLOGICAL AND NEURAL BASES OF SPATIAL COGNITIONMarlene Behrmann; Fiscal Year: 2010..Acquired attentional deficits are notoriously difficult to rehabilitate, with profound adverse consequences for the individual, and targeted intervention efforts are urgently needed. ..
- SCHIZOPHRENIA--RELATED TRAITSDeborah Levy; Fiscal Year: 2002..Robust statistical methods for evaluating the results of genomic scans will be developed. ..
- EYE GROWTH DURING INFANCYScott Lambert; Fiscal Year: 2001..In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth which occurs in certain pathological conditions such as retinopathy of prematurity. ..
- Brain Atrophy/Diffusion Tensor Study/Multiple SclerosisRobert Fox; Fiscal Year: 2008..Furthermore, these studies should help develop improved methods for evaluating new therapeutic strategies for neuroprotection and neuroregeneration. ..
- Genetic Epidemiology of Parkinson's DiseaseKaren Marder; Fiscal Year: 2008..unreadable] [unreadable]..
- TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSEWilliam Iacono; Fiscal Year: 2007..abstract_text> ..
- FMRI in Pre-Symptomatic PS1-related Alzheimer's DiseaseJohn Ringman; Fiscal Year: 2005..UCI, with its strong dementia research program, growing MRI capabilities and opportunity to collaborate at the nearby UCLA Brain Imaging Center, is an excellent environment for this endeavor. ..
- Disparity Processing in Sensory and Motor FunctionsCLIFTON SCHOR; Fiscal Year: 2005..This noise reduction should expand the spatial range of high-resolution stereo-slant perception. ..
- PSYCHOMOTILITY AND COGNITIVE STYLE IN THE SCHIZOPHRENIASDeborah Levy; Fiscal Year: 2006..Perception of snowflakes, on the other hand, tests object working memory without a verbal component. fMRl of patients and relatives while performaning these working tasks will also be undertaken. ..
- AUTISM AND ADHD: EXECUTIVE FUNCTION AND BRAIN MECHANISMSMELISSA GOLDBERG; Fiscal Year: 2004..Dr. Godfrey Pearlson, an expert in neuroimaging of mental disorders, will provide primary mentorship. A number of consultants will supplement the mentor's areas of expertise. ..
- Genetic and anatomic basis of the fibrosis syndromesElizabeth C Engle; Fiscal Year: 2011..Aim 3: Define the cellular consequences of the R954W amino acid substitution on the developing and mature ocular motor axis in mice. Aim 4: Identify KIF21A protein binding partners. ..
- VISUAL DEVELOPMENT OF SENSORY AND MOTOR FUNCTIONSCLIFTON SCHOR; Fiscal Year: 2007..The results of these experiments should provide definitive answers to several longstanding questions concerning the coordination of binocular control. ..
- Genetic Polymorphism of a Schizophrenia EndophenotypeIkwunga Wonodi; Fiscal Year: 2007..Deciphering the genetic mechanisms of prefrontal dopamine dysfunction in schizophrenia would advance our understanding of the pathophysiology of schizophrenia and may help identify novel treatments. [unreadable] [unreadable] [unreadable]..
- fMRI of Cholinergic Dysfunction in SchizophreniaJason Tregellas; Fiscal Year: 2003..abstract_text> ..
- Analysis of Fbx2 Family of Ubiquitin LigasesHenry Paulson; Fiscal Year: 2007..The results may also have implications for the pathogenesis of two poorly understood neurological diseases, DYT1 dystonia and familial neuroserpin dementia. ..
- OCULAR MOTOR AND NEUROANATOMIC STUDIES OF SCHIZOPHRENIABRETT CLEMENTZ; Fiscal Year: 2003..In this regard, it will be especially important to refine stimulus conditions to the point where measurement error is reduced as much as is practically feasible, a goal toward which we will aspire with our proposed research. ..
- CONVERGENCE INSUFFICIENCY TREATMENT TRIALMarjean Kulp; Fiscal Year: 2006..S. The Study Chair is located at the [unreadable] Pennsylvania College of Optometry and the national Data Coordinating Center is located at The Ohio State University Optometry Coordinating Center. [unreadable] [unreadable]..
- VISION SCREENING IN PRESCHOOLERS/TOSU CLINICAL CENTERMarjean Kulp; Fiscal Year: 2004..Complete details of the VIP Study rationale, design, and methods are contained in the VIP Manual of Procedures (MOP), which is submitted with the VIP Study chair application. ..
- Contribution of Spinal Segments to Control of PostureSandra Saavedra; Fiscal Year: 2008..The technique will also enhance the potential for research on development of motor control of the trunk. [unreadable] [unreadable] [unreadable]..
- MEG STUDIES OF P50 SUPPRESSION IN SCHIZOPHRENIABRETT CLEMENTZ; Fiscal Year: 2007..In addition, dysfunction of left auditory cortex impedes proper inter-hemispheric communication, which interferes with the ability to generate normal recognition-type responses measured during oddball-type paradigms. ..