ocular motility disorders

Summary

Summary: Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)

Top Publications

  1. ncbi Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson's disease
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 256:1438-46. 2009
  2. pmc Recent progress in understanding congenital cranial dysinnervation disorders
    Darren T Oystreck
    Department of Ophthalmology, College of Medicine, King Saud University, and King Abdulaziz University Hospital, Riyadh, Saudi Arabia
    J Neuroophthalmol 31:69-77. 2011
  3. ncbi Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain 128:1267-76. 2005
  4. pmc Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease
    Ashley J Hood
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
    J Neurol Neurosurg Psychiatry 78:565-70. 2007
  5. pmc (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2
    Isabelle Iltis
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res 1358:200-10. 2010
  6. ncbi Eye movements in chorea-acanthocytosis
    Libe Gradstein
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:1979-87. 2005
  7. pmc Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish
    H A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Genes Brain Behav 8:500-11. 2009
  8. ncbi Cerebellar ataxia with oculomotor apraxia type 1: clinical and genetic studies
    Isabelle Le Ber
    Federation de Neurologie, Hôpital de la Salpêtrière AP HP, Paris, France
    Brain 126:2761-72. 2003
  9. ncbi 110th ENMC International Workshop: the congenital cranial dysinnervation disorders (CCDDs). Naarden, The Netherlands, 25-27 October, 2002
    N J Gutowski
    Department of Neurology, Royal Devon and Exeter Hospital, Barrack Road, EX2 5DW, Exeter, UK
    Neuromuscul Disord 13:573-8. 2003
  10. pmc CEP290 mutations are frequently identified in the oculo-renal form of Joubert syndrome-related disorders
    Francesco Brancati
    IRCCS CSS, Mendel Institute, Viale Regina Margherita 261, 00198, Rome, Italy
    Am J Hum Genet 81:104-13. 2007

Research Grants

  1. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2005
  2. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2007
  3. VISUAL PROCESSING & SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 1999
  4. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 2000
  5. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 1999
  6. Advances in Oculomotor and Vestibular Systems
    Neeraj J Gandhi; Fiscal Year: 2010
  7. GROWTH HORMONE REGULATION OF PUBERTY & FERTILITY
    Mark Wilson; Fiscal Year: 2000
  8. CEREBRAL CORTICAL MECHANISMS FOR CONTROL OF SACCADES
    Mark Moster; Fiscal Year: 1990
  9. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2001
  10. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2004

Detail Information

Publications187 found, 100 shown here

  1. ncbi Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson's disease
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 256:1438-46. 2009
    ..The differences in pursuit tracking between PD and MSA were large enough to warrant their use as ancillary diagnostic criteria for the distinction between these disorders...
  2. pmc Recent progress in understanding congenital cranial dysinnervation disorders
    Darren T Oystreck
    Department of Ophthalmology, College of Medicine, King Saud University, and King Abdulaziz University Hospital, Riyadh, Saudi Arabia
    J Neuroophthalmol 31:69-77. 2011
    ..This report provides an update 8 years after that original report...
  3. ncbi Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain 128:1267-76. 2005
    ..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
  4. pmc Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease
    Ashley J Hood
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
    J Neurol Neurosurg Psychiatry 78:565-70. 2007
    ..Previous studies have shown that patients with PD have impaired executive function, including deficits in attention, motor planning and decision making...
  5. pmc (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2
    Isabelle Iltis
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res 1358:200-10. 2010
    ..We aimed at assessing the neurochemical profile of the pons, the cerebellar hemisphere and the vermis in patients with FRDA and AOA2 to identify potential biomarkers of these diseases...
  6. ncbi Eye movements in chorea-acanthocytosis
    Libe Gradstein
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:1979-87. 2005
    ..In contrast to Huntington's disease (for which ChAc has occasionally been mistaken), ocular involvement in ChAc has not been systematically studied...
  7. pmc Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish
    H A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Genes Brain Behav 8:500-11. 2009
    ..Moreover, we show that twitch twice mutants exhibit normal visual acuity but display defects in horizontal eye movements, suggesting a specific and critical role for twitch twice/robo3 in sensory-guided behavior...
  8. ncbi Cerebellar ataxia with oculomotor apraxia type 1: clinical and genetic studies
    Isabelle Le Ber
    Federation de Neurologie, Hôpital de la Salpêtrière AP HP, Paris, France
    Brain 126:2761-72. 2003
    ..The frequency of chorea at onset suggests that this diagnosis should also be considered in children with chorea who do not carry the IT15 mutation responsible for Huntington's disease...
  9. ncbi 110th ENMC International Workshop: the congenital cranial dysinnervation disorders (CCDDs). Naarden, The Netherlands, 25-27 October, 2002
    N J Gutowski
    Department of Neurology, Royal Devon and Exeter Hospital, Barrack Road, EX2 5DW, Exeter, UK
    Neuromuscul Disord 13:573-8. 2003
  10. pmc CEP290 mutations are frequently identified in the oculo-renal form of Joubert syndrome-related disorders
    Francesco Brancati
    IRCCS CSS, Mendel Institute, Viale Regina Margherita 261, 00198, Rome, Italy
    Am J Hum Genet 81:104-13. 2007
    ..One patient with mutation displayed complete situs inversus, confirming the clinical and genetic overlap between JSRDs and other ciliopathies...
  11. ncbi Identification of the first AHI1 gene mutations in nephronophthisis-associated Joubert syndrome
    Boris Utsch
    Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, USA
    Pediatr Nephrol 21:32-5. 2006
    ..One patient had the association of JBTS and NPHP with chronic renal failure. This is the first report of AHI1 mutations causing JBTS associated with NPHP, confirming the clinical and genetic heterogeneity of NPHP...
  12. ncbi Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3
    T M Bosley
    Neuro Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Neurology 64:1196-203. 2005
    ....
  13. ncbi Diagnostic yield of the evaluation of isolated third nerve palsy in adults
    Kara L Schultz
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Can J Ophthalmol 42:110-5. 2007
    ..We aim to define diagnostic yield for neuroimaging of third nerve palsy (TNP) by degree of internal and external dysfunction using previously published imaging guidelines...
  14. ncbi Infantile Parkinsonism-dystonia and elevated dopamine metabolites in CSF
    B E Assmann
    Department of General Pediatrics, University Children s Hospital, Duesseldorf, Germany
    Neurology 62:1872-4. 2004
    ..Pyramidal tract signs also emerged in the course of the disease in two patients. This combination of symptoms and biochemical findings suggests a unique pathogenic mechanism...
  15. ncbi Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates
    A M Wong
    Division of Neurology, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Neurol Sci 189:71-81. 2001
    ..Malfunction of Purkinje cells in the dorsal vermis, which inhibit the FOR, may cause opsoclonus by disinhibiting it...
  16. doi Neuro-ophthalmologic manifestations of paraneoplastic syndromes
    Melissa W Ko
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroophthalmol 28:58-68. 2008
    ..Most of these disorders are related to immunologic mechanisms presumably triggered by the neoplastic expression of neuronal proteins. Accurate recognition is essential to appropriate management...
  17. pmc Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neuroophthalmol 28:329-36. 2008
    ..Our simulations suggest that alterations in membrane properties that lead to an increase in PIR, a reduction in external glycinergic inhibition, or both can cause saccadic oscillations...
  18. pmc CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290
    Nicholas T Gorden
    Division of Genetics and Developmental Medicine, Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 83:559-71. 2008
    ..These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies...
  19. ncbi Allelic ROBO3 heterogeneity in Tunisian patients with horizontal gaze palsy with progressive scoliosis
    Rim Amouri
    Laboratoire de Neurobiologie Moleculaire et de Neuropathologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia
    J Mol Neurosci 39:337-41. 2009
    ..This study extends the molecular spectrum of the ROBO3 gene and the geographic origin of patients with ROBO3 gene mutations, and underlines the homogeneity of the motor ocular syndrome whatever type of mutation is encountered...
  20. ncbi Neuropathology of Joubert syndrome
    A T Yachnis
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine and UF Brain Institute, Gainesville 32610 0275, USA
    J Child Neurol 14:655-9; discussion 669-72. 1999
    ..The latter could explain certain clinical features of the syndrome, including episodic hyperpnea and oculomotor apraxia...
  21. doi Synergistic convergence in congenital extraocular muscle misinnervation
    Christina Pieh
    Arch Ophthalmol 126:574-6. 2008
  22. ncbi Therapeutic considerations for eye movement disorders
    A Straube
    Department of Neurology, University of Munich, Munich, Germany
    Dev Ophthalmol 40:175-92. 2007
    ..Finally, anticonvulsants like carbamazepine are the drugs of choice for disorders involving a nerve-blood vessel contact that induces symptoms of vestibular paroxysmia or superior oblique myokymia...
  23. pmc Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3
    W M Chan
    J Med Genet 43:e11. 2006
    ..We previously reported that HGPPS patients from consanguineous pedigrees harbour homozygous mutations in the axon guidance molecule ROBO3...
  24. doi Bilateral synergistic convergence associated with homozygous ROB03 mutation (p.Pro771Leu)
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 115:2262-5. 2008
    ..To document the phenotype and determine the genotype of a child with synergistic convergence...
  25. doi Ophthalmic features of Joubert syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Ophthalmology 115:2286-9. 2008
    ..The objective of the current study is to describe the ophthalmic phenotype in a cohort of patients with Joubert syndrome for whom the diagnosis was made using current diagnostic criteria...
  26. ncbi Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders
    Alexander E Volk
    Institute of Human Genetics, University Hospital of Cologne, Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1351-7. 2010
    ..We screened for CHN1 mutations in patients with various congenital ocular motility disorders.
  27. ncbi Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus
    K Hufner
    Department of Neurology, Klinikum Grosshadern, Neurologisches Forschungshaus, Munich, Germany
    Neurology 69:1128-35. 2007
    ..Forty percent of patients with DBN are classified as having idiopathic DBN, because no underlying pathology can be demonstrated by conventional MRI or laboratory tests...
  28. ncbi Oculomotility disorders arising from disruptions in brainstem motor neuron development
    Elizabeth C Engle
    Program in Genomics, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 64:633-7. 2007
    ....
  29. ncbi Smooth pursuit in patients with downbeat nystagmus
    Stefan Glasauer
    Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilian University, Munich, Germany
    Ann N Y Acad Sci 1039:532-5. 2005
    ....
  30. ncbi Are orthoptic exercises an effective treatment for convergence and fusion deficiencies?
    S Aziz
    Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK
    Strabismus 14:183-9. 2006
    ..To investigate whether orthoptic exercises are an effective way to influence the near point of convergence, fusion range and asthenopic symptoms...
  31. pmc Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testing
    G Amoiridis
    Department of Neurology, University of Crete, PO Box 2208, 71003 Heraklion, Greece
    J Neurol Neurosurg Psychiatry 77:1047-53. 2006
    ..Although there is evidence for uncrossed cuneatal and corticospinal tracts in HGPPS, it is unclear whether other central nervous system pathways are involved...
  32. ncbi A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
    Aasef G Shaikh
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 130:3020-31. 2007
    ....
  33. ncbi Disruption of smooth pursuit eye movements in cirrhosis: relationship to hepatic encephalopathy and its treatment
    Sara Montagnese
    Centre for Hepatology, Department of Medicine, Hampstead Campus, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, United Kingdom
    Hepatology 42:772-81. 2005
    ..Treatment status confounds the classification of neuropsychiatric status and should be taken into account when categorizing these patients...
  34. ncbi A randomized clinical trial of treatments for convergence insufficiency in children
    Mitchell Scheiman
    Eye Institute, Pennsylvania College of Optometry, Philadelphia 19141, USA
    Arch Ophthalmol 123:14-24. 2005
    ..To compare vision therapy/orthoptics, pencil push-ups, and placebo vision therapy/orthoptics as treatments for symptomatic convergence insufficiency in children 9 to 18 years of age...
  35. pmc Randomised clinical trial of the effectiveness of base-in prism reading glasses versus placebo reading glasses for symptomatic convergence insufficiency in children
    M Scheiman
    Eye Institute, Pennsylvania College of Optometry, 1200 West Godfrey Ave, Philadelphia, PA 19141, USA
    Br J Ophthalmol 89:1318-23. 2005
    ..To compare base-in prism reading glasses with placebo reading glasses for the treatment of symptomatic convergence insufficiency (CI) in children aged 9 to <18 years...
  36. ncbi Acquired simulated brown syndrome following surgical repair of medial orbital wall fracture
    Jong uk Hwang
    Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Ophthalmol 19:80-3. 2005
    ..Postoperatively, the patient was asymptomatic in all diagnostic gaze positions...
  37. ncbi Molar tooth sign in fetal brain magnetic resonance imaging leading to the prenatal diagnosis of Joubert syndrome and related disorders
    Joel Fluss
    Division of Pediatric Neurology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Child Neurol 21:320-4. 2006
    ..We report a case of Joubert syndrome diagnosed prenatally using fetal MRI. We also discuss the etiology of Joubert syndrome in view of the recent genetic advances and murine models of cerebellar dysgenesis...
  38. ncbi Efficacy of treatment for convergence insufficiency using vision therapy
    Paul Adler
    Ophthalmic Physiol Opt 22:565-71. 2002
    ..The study also evaluates the associated symptoms before and after therapy...
  39. ncbi Acquired Pseudo-Brown's syndrome immediately following Ahmed valve glaucoma implant
    D K Coats
    Cullen Eye Institute, Baylor College of Medicine, Texas Children s Hospital, Houston 77030, USA
    Ophthalmic Surg Lasers 30:396-7. 1999
    ..Implant-orbital disproportion can produce a pseudo-Brown's syndrome. Surgeons are encouraged to perform forced duction testing at the time of glaucoma implant placement to detect and prevent this complication...
  40. ncbi Molar tooth sign in Joubert syndrome: clinical, radiologic, and pathologic significance
    B L Maria
    Department of Pediatrics, University of Florida, Gainesville, USA
    J Child Neurol 14:368-76. 1999
    ..A better understanding of the clinical, radiologic, and pathologic features of Joubert syndrome should help uncover the genetic basis for the syndrome...
  41. ncbi Clinical features and revised diagnostic criteria in Joubert syndrome
    B L Maria
    Department of Pediatrics, University of Florida, Gainesville, USA
    J Child Neurol 14:583-90; discussion 590-1. 1999
    ..We propose a revision in diagnostic criteria for Joubert syndrome...
  42. ncbi Cognition, behavior, and development in Joubert syndrome
    E B Fennell
    Department of Clinical and Health Psychology, University of Florida, Gainesville 32610 0165, USA
    J Child Neurol 14:592-6. 1999
    ..Future directions of research with this rare disorder are suggested...
  43. doi Ophthalmological findings in Joubert syndrome
    V Sturm
    Department of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
    Eye (Lond) 24:222-5. 2010
    ..It has been associated with ocular and oculomotor abnormalities. The aim of our study was to extend the ophthalmic knowledge in JS and to add new findings...
  44. ncbi A survey of treatment modalities for convergence insufficiency
    Mitchell Scheiman
    Pennsylvania College of Optometry, Philadelphia 19141, USA
    Optom Vis Sci 79:151-7. 2002
    ..The purpose of this study was to investigate the care process for Cl by surveying eyecare professionals regarding the most common treatment modalities used by both optometrists and ophthalmologists across the United States...
  45. ncbi Joubert syndrome with associated corpus callosum agenesis
    N Zamponi
    Pediatric Neurology Department, Children s Hospital G Salesi, Ancona, Italy
    Eur J Paediatr Neurol 6:63-6. 2002
    ..Nevertheless, the hypothesis of a developmental abnormality of midline structures extended to the supratentorial compartment is rather attractive...
  46. ncbi The effectiveness of pencil pushups treatment for convergence insufficiency: a pilot study
    Michael Gallaway
    Pennsylvania College of Optometry, Philadelphia 19141 3322, USA
    Optom Vis Sci 79:265-7. 2002
    ..To study the effectiveness of pencil pushups treatment (PPT) for the treatment of convergence insufficiency in a clinical situation...
  47. doi Pontine warning syndrome
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Ste 931, Toronto ONM5C1R6, Canada
    Arch Neurol 65:1375-7. 2008
    ..Little is known about stroke mechanisms in patients with fluctuating symptoms and the role of branch atherosclerotic disease...
  48. pmc Eye movement abnormalities in Joubert syndrome
    Avery H Weiss
    Division of Ophthalmology, Children s Hospital and Regional Medical Center, Seattle, Washington 98115, USA
    Invest Ophthalmol Vis Sci 50:4669-77. 2009
    ..The goal of the study was to quantify the eye movement abnormalities that occur in Joubert syndrome...
  49. ncbi Self-control during response conflict by human supplementary eye field
    Masud Husain
    Imperial College, Division of Neuroscience and Psychological Medicine, Charing Cross Hospital, London W6 8RF, UK
    Nat Neurosci 6:117-8. 2003
  50. ncbi Ocular and oculomotor signs in Joubert syndrome
    R J Tusa
    Bascom Palmer Eye Institute, University of Miami, FL 33101, USA
    J Child Neurol 14:621-7. 1999
    ....
  51. ncbi Functional MRI, DTI and neurophysiology in horizontal gaze palsy with progressive scoliosis
    Sven Haller
    Institute of Radiology, Department of Neuroradiology, University Hospital Basel, Basel, Switzerland
    Neuroradiology 50:453-9. 2008
    ..This rare disease is of particular interest because the absence, or at least reduction, of crossing of the ascending lemniscal and descending corticospinal tracts in the medulla predicts abnormal ipsilateral sensory and motor systems...
  52. ncbi Retinitis pigmentosa associated with blepharophimosis, blue dot cataract and primary inferior oblique overaction: a new syndrome complex?
    Vasumathy Vedantham
    Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Indian J Ophthalmol 55:150-1. 2007
    ..Computerized search using Medline did not reveal any such previously reported association...
  53. ncbi Smooth pursuit eye movements in 1,087 men: effects of schizotypy, anxiety, and depression
    Nikolaos Smyrnis
    University Mental Health Research Institute, Athens, Greece
    Exp Brain Res 179:397-408. 2007
    ....
  54. ncbi Hemispheric asymmetry of gaze deviation and relationship to neglect in acute stroke
    J M Ringman
    Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
    Neurology 65:1661-2. 2005
    ..There was no difference in its rate of co-occurrence with neglect between right- and nonright-handed patients...
  55. ncbi Long-term results of silicone expander for moderate and severe Brown syndrome (Brown syndrome "plus")
    D R Stager
    UT Southwestern Medical School and the Pediatric Ophthalmology, PA, Dallas, Texas 75225, USA
    J AAPOS 3:328-32. 1999
    ..Dr Kenneth Wright has introduced a procedure of superior oblique muscle tenotomy with a silicone expander to reduce the incidence of overcorrection...
  56. ncbi Tendon surgery in Brown's syndrome
    R Maggi
    Bambino Gesu Children s Hospital, Rome, Italy
    J Pediatr Ophthalmol Strabismus 39:33-8. 2002
    ..Longitudinal tenectomy of the reflected tendon of the superior oblique muscle resulted in full recovery in a series of cases of Brown's syndrome after surgery by one of the authors...
  57. doi Latency of saccades and vergence eye movements in dyslexic children
    Maria Pia Bucci
    IRIS, FRE 3154, CNRS, Pôle chirurgie ORL OPH, Hopital Robert Debre, 48 Bld Serurier, 75019 Paris, France
    Exp Brain Res 188:1-12. 2008
    ..Difficulties in both voluntary and reflexive control shifts of visual attention from near to far distance in dyslexics could be at the origin of these findings...
  58. ncbi Fibrotic superior oblique and superior rectus muscles with an accessory tissue band
    Seyhan B Ozkan
    Adnan Menderes University, Department of Ophthalmology, Aydin, Turkey
    J AAPOS 11:491-4. 2007
    ..To the best of our knowledge, there is only one partially similar case in the literature with coexistence of congenitally fibrotic superior rectus and superior oblique muscles, and the features of that case differ from those of our case...
  59. ncbi Ocular torsion produced by unilateral chemical inactivation of the cerebellar flocculus in alert cats
    Shinki Chin
    Department of Ophthalmology and Visual Sciences, Hokkaido University, Sapporo, Japan
    Curr Eye Res 25:133-8. 2002
    ..To test whether the cerebellar flocculus is involved in the control of torsional eye position, we examined the effects of unilateral chemical inactivation of the flocculus on ocular torsion in alert cats...
  60. ncbi Symptomatic convergence insufficiency. Interview by Leonard B. Nelson
    Kathleen Mahon
    J Pediatr Ophthalmol Strabismus 44:202-6. 2007
  61. ncbi Superior oblique tendon incarceration syndrome
    Burton J Kushner
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Hospital and Clinics, 2870 University Ave, Suite 206, Madison, WI 53705, USA
    Arch Ophthalmol 125:1070-6. 2007
    ..To describe the clinical features, etiology, and management of superior oblique tendon incarceration syndrome...
  62. ncbi Cerebellar activation in opsoclonus: an fMRI study
    C Helmchen
    Department of Neurology, University of Lubeck, Germany
    Neurology 61:412-5. 2003
    ..The results support a crucial role of the fastigial nucleus in opsoclonus...
  63. pmc Ocular motility and Wilson's disease: a study on 34 patients
    I Ingster-Moati
    université Paris 7 Diderot, Assistance Publique Hopitaux de Paris, Hopital Necker, Department of Ophthalmology, INSERM, U669, Paris, France
    J Neurol Neurosurg Psychiatry 78:1199-201. 2007
    ..The excessive accumulation of copper in the brain induces an extrapyramidal syndrome. Oculomotor abnormalities occur in most extrapyramidal disorders but have rarely been studied in Wilson's disease...
  64. ncbi Linear nondisplaced orbital fractures with muscle entrapment
    Marc R Criden
    Department of Ophthalmology, Case Western Reserve University School of Medicine, Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    J AAPOS 11:142-7. 2007
    ..This study reviews the clinical findings, radiologic findings and interpretations, preoperative and postoperative ocular motility, and outcomes in this subset of orbital fracture patients treated with early surgical repair...
  65. ncbi Wall-eyed bilateral internuclear ophthalmoplegia from lesions at different levels in the brainstem
    Chien Ming Chen
    Section of Neurology, Department of Internal Medicine, Feng Yuan Hospital, Department of Health, Executive Yuan, Taiwan, Republic of China
    J Neuroophthalmol 27:9-15. 2007
    ..In a study of the clinical and imaging features of four patients with WEBINO, we found that that three of four lesions involved the midbrain but not necessarily the medial rectus subnuclei...
  66. ncbi Large-segment superior oblique tendon expanders in the management of severe congenital Brown syndrome
    Abdulaziz H Awad
    Department of Medical Education, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 7:274-8. 2003
    ..To report the effectiveness of large-segment superior oblique tendon expanders for severe congenital Brown syndrome...
  67. ncbi Active management in patients with ocular manifestations of myasthenia gravis
    C R Bentley
    Moorfields Eye Hospital, London, UK
    Eye 15:18-22. 2001
    ..Active intervention should be considered when deviations become stable. To our knowledge this is the first report of the use of botulinum toxin in such patients...
  68. doi Teaching NeuroImage: one-and-a-half syndrome
    Patricio S Espinosa
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Neurology 70:e20. 2008
  69. ncbi Quantitative evaluation of ocular motility in blow-out fractures for selection of nonsurgically managed cases
    Yasuhiro Nishida
    Department of Ophthalmology, Shiga University of Medical Science, Tsukinowa, Otsu, Shiga, Japan
    Am J Ophthalmol 137:777-9. 2004
    ..To clarify in which cases of blow-out fractures ocular motility will naturally recover...
  70. ncbi Reexploration and inferior oblique myectomy temporal to the inferior rectus to treat persistent inferior oblique overaction
    David M Squirrell
    Department of Ophthalmology, Royal Hallamshire Hospital, Glossop Road, Sheffield, England
    J AAPOS 11:48-51. 2007
    ..We describe the results of reexploration and myectomy of the IO muscle using a standard inferotemporal approach to treat this clinical entity...
  71. ncbi Neural activation associated with corrective saccades during tasks with fixation, pursuit and saccades
    Sven Haller
    Institute of Radiology, Department of Neuroradiology, University Hospital Basel, CH 4031, Basel, Switzerland
    Exp Brain Res 184:83-94. 2008
    ....
  72. ncbi Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16
    Bernard S Chang
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Ann Neurol 53:596-606. 2003
    ..Because 11 of our patients initially were classified as having other malformations, the syndrome of BFPP appears to be more common than previously recognized and may be frequently misdiagnosed...
  73. doi Pearls & Oy-sters: The medial longitudinal fasciculus in ocular motor physiology
    T C Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX75235, USA
    Neurology 70:e57-67. 2008
    ..To review the role played by the medial longitudinal fasciculus (MLF) in ocular motor physiology and to characterize a number of syndromes that result from lesions in this eloquent brainstem tract system...
  74. pmc Suppression of saccadic intrusions in hereditary ataxia by memantine
    A Serra
    Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Neurology 70:810-2. 2008
  75. doi Extraocular muscle hypertrophy in myotonia congenita
    Bradley Wakeman
    Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada
    J AAPOS 12:294-6. 2008
    ..Esotropia and reduced saccadic velocities have been reported in the dominant form of MC. We report two cases in which orbital magnetic resonance imaging (MRI) imaging showed extraocular muscle hypertrophy...
  76. doi Modeling Uhthoff's phenomenon in MS patients with internuclear ophthalmoparesis
    S L Davis
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX, USA
    Neurology 70:1098-106. 2008
    ....
  77. doi Taking the temperature of MS with INO
    R John Leigh
    Neurology 70:1063-4. 2008
  78. ncbi Ocular and oculomotor findings of Joubert syndrome
    Kadircan H Keskinbora
    J Pediatr Ophthalmol Strabismus 45:5-6. 2008
  79. ncbi Wall-eyed bilateral internuclear ophthalmoplegia in a patient with progressive supranuclear palsy
    Munetaka Ushio
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neuroophthalmol 28:93-6. 2008
    ....
  80. ncbi Acquired brown syndrome secondary to superior oblique muscle cysticercosis
    Venkateshwar B Rao
    Department of Pediatric Ophthalmology and Strabismus, Jasti V Ramanamma Children s Eye Care Centre, L V Prasad Eye Institute, Hyderabad, India
    J AAPOS 7:23-7. 2003
    ..The purpose of this study is to report a large series of patients with acquired Brown syndrome secondary to superior oblique muscle cysticercosis and to discuss its management...
  81. ncbi Dissociated palsy of vertical saccades: loss of voluntary and visually guided saccades with preservation of reflexive vestibular quick phases
    Ji Hoon Kang
    Department of Neurology, Cheju National University College of Medicine, Cheju, Republic of Korea
    J Neuroophthalmol 28:97-103. 2008
    ....
  82. ncbi Selective saccadic palsy after cardiac surgery
    Scott D Z Eggers
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 70:318-20. 2008
  83. ncbi What is pathological with gaze shift fragmentation in Parkinson's disease?
    Hubert Kimmig
    Neurologische Universitatsklinik, Breisacher Strasse 64, 79106 Freiburg, Germany
    J Neurol 249:683-92. 2002
    ..Thus, only the abnormally high incidence of fragmentation, and of the associated amplitude reduction of the primary saccades, rather than the phenomenon per se, can be used as a diagnostic criterion in early stages of PD...
  84. ncbi Resolution of superior oblique myokymia with memantine
    Saurabh Jain
    Leicester Royal Infirmary, Leicester, United Kingdom
    J AAPOS 12:87-8. 2008
    ..After a drug holiday, memantine therapy was initiated resulting in a substantial improvement in her symptoms with far fewer side effects and stability on long-term maintenance therapy...
  85. ncbi Hypoplastic inferior rectus muscle in association with accessory extraocular muscle and globe retraction
    Seyhan B Ozkan
    Department of Ophthalmology, Adnan Menderes University, Aydin, Turkey
    J AAPOS 11:488-90. 2007
    ..We present a case with bilateral hypoplasia of the inferior rectus muscle with an accessory extraocular muscle in association with globe retraction and lambda-pattern exodeviation...
  86. ncbi Improving antisaccade performance in adolescents with attention-deficit/hyperactivity disorder (ADHD)
    Canan Karatekin
    Institute of Child Development, University of Minnesota, 51 E River Road, Minneapolis, MN 55455, USA
    Exp Brain Res 174:324-41. 2006
    ..The findings suggest that cognitive scaffolds can ameliorate at least some of the inhibition deficits in adolescents with ADHD...
  87. doi Teaching NeuroImage: Convergence spasm associated with midbrain compression by cerebral aneurysm
    Konrad P Weber
    Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
    Neurology 70:e49-50. 2008
  88. ncbi Traumatic tear of the inferior rectus muscle treated with inferior oblique anterior transposition
    Katyanne Dantas Godeiro
    Henry C Witelson Ocular Pathology Laboratory, Department of Ophthalmology, McGill University, Lyman Duff Building, 3775 University Street, Room 216, Montreal, QC, Canada, H3A 2B4
    Int Ophthalmol 26:185-9. 2005
    ..To report a case of traumatic tear of the inferior rectus muscle treated with inferior oblique anterior transposition (IOAT)...
  89. ncbi "Inverted Brown pattern": a tight inferior oblique muscle masquerading as a superior oblique muscle underaction--clinical characteristics and surgical management
    Ahmed Awadein
    The Zanvyl Krieger Children s Eye Center at the Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9028, USA
    J AAPOS 10:565-72. 2006
    ..To characterize, and evaluate the surgical management of, patients with unilateral deficiency of depression in adduction, suggesting superior oblique muscle underaction, without significant ipsilateral inferior oblique muscle overaction...
  90. ncbi [The effect of weakening inferior oblique muscles on the status of ocular torsion]
    Guang huan Mai
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
    Zhonghua Yan Ke Za Zhi 40:243-6. 2004
    ..To understand the clinical significance of subjective and objective examination of cyclodeviations and investigate the effect of weakening inferior oblique muscles on the status of ocular torsion...
  91. ncbi Superior oblique posterior tenectomy in patients with Brown syndrome with small deviations in the primary position
    Federico G Velez
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    J AAPOS 10:214-9. 2006
    ..SO posterior tenectomy moderately weakens abduction and depression while preserving most of the torsional action of the SO muscle...
  92. ncbi Cerebellar skew deviation and the torsional vestibuloocular reflex
    Agnes M F Wong
    Division of Neurology, Department of Ophthalmology and Vision Science, University Health Network, University of Toronto, Ontario, Canada
    Neurology 65:412-9. 2005
    ....
  93. ncbi Treatment of inferior oblique paresis with superior oblique silicone tendon expander
    Marc F Greenberg
    Eye Consultants of Atlanta, Children s Healthcare of Atlanta at Scottish Rite, Atlanta, Georgia, USA
    J AAPOS 9:341-5. 2005
    ..We report 8 such patients successfully treated using unilateral silicone superior oblique (SO) tendon expanders...
  94. ncbi Canine tooth syndrome due to superior oblique myocysticercosis
    Pramod Kumar Pandey
    Strabismus Service, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, India
    J Pediatr Ophthalmol Strabismus 43:185-7. 2006
    ..Oral treatment was prescribed. MRI revealed a collapsed cyst. Ocular motility improved, but levoelevation diplopia persisted...
  95. ncbi Eye movement abnormalities in stiff person syndrome
    John R Economides
    Beckman Vision Center, University of California, San Francisco, CA 94143 0730, USA
    Neurology 65:1462-4. 2005
    ..There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA...
  96. ncbi High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome
    Rahul Bhola
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095 7002, USA
    J AAPOS 9:438-48. 2005
    ..Although Brown syndrome classically is considered to be limited to the SO tendon sheath and trochlea, it does not always respond to SO surgery. We investigated mechanisms of Brown syndrome by magnetic resonance imaging (MRI)...
  97. ncbi Internuclear ophthalmoplegia: causes and long-term follow-up in 65 patients
    I Bolaños
    Department of Neuroophthalmology, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico
    Acta Neurol Scand 110:161-5. 2004
    ..To analyze the causes and long-term clinical outcome of internuclear ophthalmoplegia (INO) in a consecutive series of 65 patients...
  98. pmc Surgical outcomes in correction of Brown syndrome
    Yoonae A Cho
    Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea
    Korean J Ophthalmol 20:33-40. 2006
    ..To evaluate the outcomes of surgery for Brown syndrome...
  99. ncbi Extraocular muscle cysticercosis - a clinical challenge to the ophthalmologists
    Padmaja Minakshi Sundaram
    Department of Neuro Ophthalmology, Medical Research Foundation, Sankara Nethralaya
    Orbit 23:255-62. 2004
    ..To report our experience with extraocular myocysticercosis, to highlight the role of ultrasound and orbital computerized tomography (CT) scan in these cases and to discuss the management...
  100. ncbi Medial medullary infarction: abnormal ocular motor findings
    J Soo Kim
    Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea
    Neurology 65:1294-8. 2005
    ..The ocular motor abnormalities may be explained by involvements of the nucleus prepositus hypoglossi, medial longitudinal fasciculus or efferent fibers from the vestibular nuclei, climbing fibers, and cells of the paramedian tracts...
  101. ncbi Square wave jerks in children and adolescents
    Michael S Salman
    Section of Pediatric Neurology, Children s Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Neurol 38:16-9. 2008
    ..The prevalence of square wave jerks is high in children and adolescents. This finding may be a feature of the less mature brain, and may reflect an inability to suppress unwanted supranuclear triggers for saccades...

Research Grants104 found, 100 shown here

  1. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2005
    ..causal relationship between the organization of MyHC isoforms and the behavior of these atypical muscles and to establish a rationale for alternative surgical and pharmacological therapies of ocular motility disorders.
  2. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2007
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. [unreadable] [unreadable]..
  3. VISUAL PROCESSING & SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 1999
    ..This understanding is necessary for the diagnosis and management of ocular motility disorders. FUNDING NIH / EY06069 $182,119 12/01/98 - 11/30/02 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 ..
  4. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 2000
    ..dystrophy and myasthenia gravis, the results of these investigations will be important for other disorders of extraocular muscle, such as strabismus, genetic ocular motility disorders, congenital myasthenic syndromes, and blepharospasm.
  5. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 1999
    ..dystrophy and myasthenia gravis, the results of these investigations will be important for other disorders of extraocular muscle, such as strabismus, genetic ocular motility disorders, congenital myasthenic syndromes, and blepharospasm.
  6. Advances in Oculomotor and Vestibular Systems
    Neeraj J Gandhi; Fiscal Year: 2010
    ..efforts of clinicians and computational scientists to simulate the pathophysiology of several ocular motility disorders. One uniqueness of the present approach has been to attribute the dysfunction to specific cell membrane ..
  7. GROWTH HORMONE REGULATION OF PUBERTY & FERTILITY
    Mark Wilson; Fiscal Year: 2000
    ..This understanding is necessary for the diagnosis and management of ocular motility disorders. FUNDING NIH / EY06069 $182,119 12/01/98 - 11/30/02 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 ..
  8. CEREBRAL CORTICAL MECHANISMS FOR CONTROL OF SACCADES
    Mark Moster; Fiscal Year: 1990
    ..The spike potential (SP), a manifestation of extraocular muscle or ocular motor nerve activity, will be tested in normal subjects and patients with ocular motility disorders to develop its diagnostic and prognostic capabilities.
  9. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2001
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  10. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2004
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  11. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2000
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  12. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2003
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  13. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2000
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  14. SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE
    John Porter; Fiscal Year: 2002
    ..An overall knowledge of the properties and regulation of the EOM sarcolemma will be important for understanding and treating ocular motility disorders in myasthenia gravis, congenital fibrosis of EOM, and strabismus.
  15. PRIMATE SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 2002
    ..This understanding is necessary for the diagnosis and management of ocular-motility disorders. ..
  16. PRIMATE SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 2001
    ..This understanding is necessary for the diagnosis and management of ocular-motility disorders. ..
  17. PRIMATE SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 1999
    ..This understanding is necessary for the diagnosis and management of ocular-motility disorders. ..
  18. PRIMATE SMOOTH EYE MOVEMENTS
    MICHAEL MUSTARI; Fiscal Year: 2000
    ..This understanding is necessary for the diagnosis and management of ocular-motility disorders. ..
  19. CLINICAL INVESTIGATIONS IN OCULAR MOTILITY DISORDERS
    Neil Miller; Fiscal Year: 1980
    ..We are also using these models to study central nervous system adaptation in patients with peripheral ocular motor nerve palsies...
  20. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2004
    ..causal relationship between the organization of MyHC isoforms and the behavior of these atypical muscles and to establish a rationale for alternative surgical and pharmacological therapies of ocular motility disorders.
  21. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2003
    ..causal relationship between the organization of MyHC isoforms and the behavior of these atypical muscles and to establish a rationale for alternative surgical and pharmacological therapies of ocular motility disorders.
  22. CELL AND MOLECULAR DIVERSITY OF EXTRAOCULAR MUSCLE
    John Porter; Fiscal Year: 1999
    ..knowledge of EOM properties and adaptive/maladaptive responses in disease will provide a mechanistic understanding of ocular motility disorders that occur in isolation from or in conjunction with those of other skeletal muscles.
  23. CORRECTION OF MYOPIA EVALUATION TRIAL (COMET)
    Mitchell Scheiman; Fiscal Year: 2002
    ..In addition to PCO, the other clinical centers are located at Colleges of Optometry in Boston, Houston, and Birmingham, with the Study Chair in Boston and the Coordinating Center at Stony Brook. ..
  24. COLLABORATIVE OBSERVATIONAL STUDY OF MYOPIA IN COMET CHILDREN
    Mitchell Scheiman; Fiscal Year: 2007
    ..In addition to PCO, the other clinical centers are located at Colleges of Optometry in Boston, Houston, and Birmingham, with the Study Chair in Boston and the Coordinating Center at Stony Brook. ..
  25. Convergence Insuffiency Treatment Trial
    Mitchell Scheiman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  26. Convergence Insuffiency Treatment Trial
    Mitchell Scheiman; Fiscal Year: 2004
    ..It includes the budget for the Study Chair's office, revised budgets for the clinical centers, the results of pilot studies funded by an NEI Clinical Trial Planning Grant, and the CITT Manual of Procedures. ..
  27. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2006
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  28. fMRI of Eye Movement Phenotype in Schizophrenia
    L Hong; Fiscal Year: 2007
    ....
  29. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2006
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. [unreadable] [unreadable]..
  30. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2005
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  31. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2005
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. ..
  32. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2004
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  33. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant Thaker; Fiscal Year: 2009
    ....
  34. Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine Addiction
    L Elliot Hong; Fiscal Year: 2010
    ....
  35. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant Thaker; Fiscal Year: 2008
    ....
  36. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. RESEARCH TRACK RESIDENCY TRAINING PROGRAM
    Gunvant Thaker; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  38. fMRI of Eye Movement Phenotype in Schizophrenia
    L Hong; Fiscal Year: 2008
    ....
  39. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant Thaker; Fiscal Year: 2007
    ....
  40. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Neural Oscillatory Biomarkers for Genetics and Animal Models of Schizophrenia
    L Elliot Hong; Fiscal Year: 2010
    ..This study will use brain electrical waves as potential biomarkers for identifying the pathophysiological and molecular causes for schizophrenia and related dysfunctions, which should lead to finding more specific and better treatment. ..
  42. RESEARCH TRACK RESIDENCY TRAINING PROGRAM
    Gunvant Thaker; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  43. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2007
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  44. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant K Thaker; Fiscal Year: 2010
    ....
  45. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2003
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  46. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 1999
    ..Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status. ..
  47. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2000
    ..Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status. ..
  48. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2004
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. ..
  49. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  50. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2001
    ..Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status. ..
  51. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2003
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. ..
  52. Short-term Training Students-Health Professional Schools
    KENNETH CIUFFREDA; Fiscal Year: 2006
    ..Trainees will consist of optometry students who have just completed either their first or second professional years, and have done well academically (3.5 gpa or better). All will have an undergraduate degree, generally in the sciences. ..
  53. Genetics of Familial Episodic Ataxia
    Joanna C Jen; Fiscal Year: 2010
    ..Insights gained from the study will lead to improved diagnosis and treatment of familial episodic ataxia and the more common episodic vertigo syndromes. ..
  54. GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2004
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  55. Neural mechanisms for antisaccade errors among schizophrenia families
    BRETT CLEMENTZ; Fiscal Year: 2009
    ..It is expected this pattern will be disrupted in people with schizophrenia and their relatives. ..
  56. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth C Engle; Fiscal Year: 2010
    ..Aim 3: Define the cellular consequences of the R954W amino acid substitution on the developing and mature ocular motor axis in mice. Aim 4: Identify KIF21A protein binding partners. ..
  57. MOLECULAR BASIS OF CONGENITAL STRABISMUS
    Elizabeth Engle; Fiscal Year: 2000
    ..abstract_text> ..
  58. New York Columbia Collaborative SPOTRIAS
    RANDOLPH MARSHALL; Fiscal Year: 2008
    ..abstract_text> ..
  59. THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2008
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  60. Integrating Quality Control: Studies of CHIP in Age-related Neurodegeneration
    Henry Paulson; Fiscal Year: 2009
    ..Understanding this machinery may suggest routes to therapy for a large range of sporadic and hereditary neurodegenerative diseases that occur as we age. ..
  61. Mechanisms of Polyglutamine Neurodegeneration
    Henry L Paulson; Fiscal Year: 2010
    ..This grant will explore the basis of SCA3 in order that we can ultimately develop therapies for this fatal disease based on a better understanding of disease mechanisms. ..
  62. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2007
    ..Aim 3: Define the cellular consequences of the R954W amino acid substitution on the developing and mature ocular motor axis in mice. Aim 4: Identify KIF21A protein binding partners. ..
  63. Genetic Etiologies of Horizontal Strabismus
    Elizabeth Engle; Fiscal Year: 2007
    ..And (5) Initiating structural and functional characterization of the horizontal CCDD genes and their protein products. ..
  64. Genetic Etiologies of Horizontal Strabismus
    Elizabeth Engle; Fiscal Year: 2007
    ..And (5) Initiating structural and functional characterization of the horizontal CCDD genes and their protein products. ..
  65. MECHANISMS OF GLUTAMINE REPEAT NEURODEGENERATION
    Henry Paulson; Fiscal Year: 2002
    ..abstract_text> ..
  66. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2004
    ..These data will be invaluable to our understanding of the developmental roles of these genes, and should also contribute to improved therapy of the fibrosis syndromes. ..
  67. Analysis of Fbx2 Family of Ubiquitin Ligases
    Henry Paulson; Fiscal Year: 2006
    ..The results may also have implications for the pathogenesis of two poorly understood neurological diseases, DYT1 dystonia and familial neuroserpin dementia. ..
  68. Genetic Etiologies of Horizontal Strabismus
    Elizabeth Engle; Fiscal Year: 2006
    ..And (5) Initiating structural and functional characterization of the horizontal CCDD genes and their protein products. ..
  69. MEG STUDIES OF P50 SUPPRESSION IN SCHIZOPHRENIA
    BRETT CLEMENTZ; Fiscal Year: 2006
    ..In addition, dysfunction of left auditory cortex impedes proper inter-hemispheric communication, which interferes with the ability to generate normal recognition-type responses measured during oddball-type paradigms. ..
  70. Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)
    Joanna C Jen; Fiscal Year: 2010
    ..abstract_text> ..
  71. CONVERGENCE INSUFFICIENCY TREATMENT TRIAL
    Marjean Kulp; Fiscal Year: 2006
    ..S. The Study Chair is located at the [unreadable] Pennsylvania College of Optometry and the national Data Coordinating Center is located at The Ohio State University Optometry Coordinating Center. [unreadable] [unreadable]..
  72. OCULAR MOTOR AND NEUROANATOMIC STUDIES OF SCHIZOPHRENIA
    BRETT CLEMENTZ; Fiscal Year: 2003
    ..In this regard, it will be especially important to refine stimulus conditions to the point where measurement error is reduced as much as is practically feasible, a goal toward which we will aspire with our proposed research. ..
  73. Genetic Etiologies of Horizontal Strabismus
    Elizabeth Engle; Fiscal Year: 2005
    ..And (5) Initiating structural and functional characterization of the horizontal CCDD genes and their protein products. ..
  74. Mechanisms of Polyglutamine Neurodegeneration
    Henry Paulson; Fiscal Year: 2007
    ..They may also shed light on the role of protein quality control, and particularly of de-ubiquitinating enzymes, in age-related neurodegenerative diseases characterized by protein misfolding and aggregation. ..
  75. Genetic Etiologies of Horizontal Strabismus
    Elizabeth Engle; Fiscal Year: 2004
    ..And (5) Initiating structural and functional characterization of the horizontal CCDD genes and their protein products. ..
  76. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2003
    ..These data will be invaluable to our understanding of the developmental roles of these genes, and should also contribute to improved therapy of the fibrosis syndromes. ..
  77. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2009
    ..Aim 3: Define the cellular consequences of the R954W amino acid substitution on the developing and mature ocular motor axis in mice. Aim 4: Identify KIF21A protein binding partners. ..
  78. THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2005
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  79. OCULAR MOTOR AND NEUROANATOMIC STUDIES OF SCHIZOPHRENIA
    BRETT CLEMENTZ; Fiscal Year: 2002
    ..In this regard, it will be especially important to refine stimulus conditions to the point where measurement error is reduced as much as is practically feasible, a goal toward which we will aspire with our proposed research. ..
  80. Genetics of Familial Episodic Ataxia
    Joanna Jen; Fiscal Year: 2009
    ..Insights gained from the study will lead to improved diagnosis and treatment of familial episodic ataxia and the more common episodic vertigo syndromes. ..
  81. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2009
    ..Aim 3: Define the cellular consequences of the R954W amino acid substitution on the developing and mature ocular motor axis in mice. Aim 4: Identify KIF21A protein binding partners. ..
  82. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2007
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  83. THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2009
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  84. MOLECULAR BASIS OF CONGENITAL STRABISMUS
    Elizabeth Engle; Fiscal Year: 2005
    ..Aim 3. Identify new vertical CCDD loci by SNP-based genome screens of unmapped pedigrees. Aim 4. Initiate structural and functional characterization of the FEOM3 and PTOS1 genes and their protein products. ..
  85. CONVERGENCE INSUFFICIENCY TREATMENT TRIAL
    Marjean Kulp; Fiscal Year: 2005
    ..In addition to TOSUCO, there are 8 other optometric/ophthalmologic clinic sites across the U.S., Study Chair (Philadelphia) and the national Coordinating Center (also located at TOSUCO). ..
  86. VISION SCREENING IN PRESCHOOLERS/TOSU CLINICAL CENTER
    Marjean Kulp; Fiscal Year: 2004
    ..Complete details of the VIP Study rationale, design, and methods are contained in the VIP Manual of Procedures (MOP), which is submitted with the VIP Study chair application. ..
  87. MOLECULAR BASIS OF CONGENITAL STRABISMUS
    Elizabeth Engle; Fiscal Year: 2006
    ..Aim 3. Identify new vertical CCDD loci by SNP-based genome screens of unmapped pedigrees. Aim 4. Initiate structural and functional characterization of the FEOM3 and PTOS1 genes and their protein products. ..
  88. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2007
    ....
  89. MEG STUDIES OF P50 SUPPRESSION IN SCHIZOPHRENIA
    BRETT CLEMENTZ; Fiscal Year: 2007
    ..In addition, dysfunction of left auditory cortex impedes proper inter-hemispheric communication, which interferes with the ability to generate normal recognition-type responses measured during oddball-type paradigms. ..
  90. MUTATIONS IN CALCIUM CHANNELS CAUSING VERTIGO AND ATAXIA
    Joanna Jen; Fiscal Year: 2002
    ..The further relevance of this work to the more common basilar migraine and Meniere's syndrome is emphasized by the overlapping symptoms of vertigo and ataxia in the group of patients that we propose to study. ..
  91. Genetic and anatomic basis of the fibrosis syndromes
    Elizabeth Engle; Fiscal Year: 2005
    ..These data will be invaluable to our understanding of the developmental roles of these genes, and should also contribute to improved therapy of the fibrosis syndromes. ..