blepharospasm

Summary

Summary: Excessive winking; tonic or clonic spasm of the orbicularis oculi muscle.

Top Publications

  1. ncbi Blepharospasm: recent advances
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 59:1306-12. 2002
  2. doi Relationship between various clinical outcome assessments in patients with blepharospasm
    Joseph Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 24:407-13. 2009
  3. doi Temporal discrimination thresholds in adult-onset primary torsion dystonia: an analysis by task type and by dystonia phenotype
    D Bradley
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol 259:77-82. 2012
  4. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
  5. doi Decreased dopamine D receptor binding in essential blepharospasm
    C Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Acta Neurol Scand 119:49-54. 2009
  6. ncbi Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 17:1017-25. 2002
  7. ncbi Relationship between eye symptoms and blepharospasm: a multicenter case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 20:1564-70. 2005
  8. pmc Craniocervical dystonia questionnaire (CDQ-24): development and validation of a disease-specific quality of life instrument
    J Muller
    University Hospital of Neurology, Innsbruck, Austria University Hospital of Psychiatry, Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 75:749-53. 2004
  9. doi Double-blind, randomised, parallel group pilot study comparing two botulinum toxin type A products for the treatment of blepharospasm
    Bettina Wabbels
    Department of Ophthalmology, University of Bonn, Abbestr 2, 53127, Bonn, Germany
    J Neural Transm 118:233-9. 2011
  10. ncbi The impact of blepharospasm and cervical dystonia on health-related quality of life and depression
    J Muller
    Department of Neurology, Innsbruck University Hospital, Anichstr 35, Austria
    J Neurol 249:842-6. 2002

Research Grants

  1. EYELID SENSORIMOTOR NETWORKS
    Mark leDoux; Fiscal Year: 2003
  2. Dystonia Coalition
    Hyder A Jinnah; Fiscal Year: 2013
  3. Kinaesthetic Loss as a Marker for Spasmodic Dysphonia
    Peter J Watson; Fiscal Year: 2012
  4. Mesenchymal Stem Cell Therapy for Corneal Cystinosis
    JENNIFER LYNNE SIMPSON; Fiscal Year: 2013
  5. A Cell-based Assay for Botulinum Neurotoxin Detection and Development
    Ward C Tucker; Fiscal Year: 2013
  6. Diagnostic Error in Dystonia
    Caroline M Tanner; Fiscal Year: 2010
  7. CONTROL OF EYELIDS IN NORMAL AND PATHOLOGICAL STATES
    LESLIE CRAIG EVINGER; Fiscal Year: 2011
  8. BOTULINUM NEUROTOXIN: MECHANISM OF TOXICITY
    BIBHUTI DASGUPTA; Fiscal Year: 1991
  9. MECHANISM OF BOTULINUM NEUROTOXIN ACTION
    Bal Ram Singh; Fiscal Year: 1999
  10. CHEMOMYECTOMY FOR EYELID SPASMS
    Linda McLoon; Fiscal Year: 1999

Detail Information

Publications221 found, 100 shown here

  1. ncbi Blepharospasm: recent advances
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 59:1306-12. 2002
    Benign essential blepharospasm is a common focal dystonia characterized by involuntary eyelid closure...
  2. doi Relationship between various clinical outcome assessments in patients with blepharospasm
    Joseph Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 24:407-13. 2009
    ..the metric properties of the Jankovic Rating Scale (JRS) and a self-rating patient response outcome scale, the Blepharospasm Disability Index (BSDI), in blepharospasm patients...
  3. doi Temporal discrimination thresholds in adult-onset primary torsion dystonia: an analysis by task type and by dystonia phenotype
    D Bradley
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol 259:77-82. 2012
    ..To investigate phenotypes, we examined 71 AOPTD patients (37 cervical dystonia, 14 writer's cramp, 9 blepharospasm, 11 spasmodic dysphonia) and 8 musician's dystonia patients...
  4. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
    This review updates understanding and research on blepharospasm, a subtype of focal dystonia. Topics covered include clinical aspects, pathology, pathophysiology, animal models, dry eye, photophobia, epidemiology, genetics, and treatment...
  5. doi Decreased dopamine D receptor binding in essential blepharospasm
    C Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Acta Neurol Scand 119:49-54. 2009
    The purpose of this study was to investigate whether dopamine D(2) receptor binding was altered in the striatum of essential blepharospasm patients.
  6. ncbi Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 17:1017-25. 2002
    ..In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil ..
  7. ncbi Relationship between eye symptoms and blepharospasm: a multicenter case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 20:1564-70. 2005
    Although patients with primary blepharospasm (BSP) commonly report experiencing ocular symptoms before the onset of orbicular spasms, the precise frequency and pathogenic role of this subjective ocular discomfort are poorly understood...
  8. pmc Craniocervical dystonia questionnaire (CDQ-24): development and validation of a disease-specific quality of life instrument
    J Muller
    University Hospital of Neurology, Innsbruck, Austria University Hospital of Psychiatry, Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 75:749-53. 2004
    ..To develop and test a questionnaire for measuring quality of life in patients with craniocervical dystonia...
  9. doi Double-blind, randomised, parallel group pilot study comparing two botulinum toxin type A products for the treatment of blepharospasm
    Bettina Wabbels
    Department of Ophthalmology, University of Bonn, Abbestr 2, 53127, Bonn, Germany
    J Neural Transm 118:233-9. 2011
    Botulinum neurotoxins (BoNTs) are the primary treatment for focal dystonias such as blepharospasm. Several different BoNT products are available in various countries...
  10. ncbi The impact of blepharospasm and cervical dystonia on health-related quality of life and depression
    J Muller
    Department of Neurology, Innsbruck University Hospital, Anichstr 35, Austria
    J Neurol 249:842-6. 2002
    ..of the study was to evaluate and compare health-related quality of life (HR-QoL) and depression in essential blepharospasm (BSP) and idiopathic cervical dystonia (CD), to identify the clinical and demographic factors associated with ..
  11. ncbi Long-term follow-up of patients with frontalis sling operation in the treatment of essential blepharospasm unresponsive to botulinum toxin therapy
    Bettina Wabbels
    Department of Ophthalmology, University of Bonn, Klinikum, Abbestrasse 2, 53127 Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 245:45-50. 2007
    Botulinum toxin is the treatment of choice in patients with essential blepharospasm, but about 4% of patients show no sufficient effect. Many of these patients try to open their eyes by innervating their frontalis muscle...
  12. ncbi Safety, effectiveness, and duration of effect of BOTOX after switching from Dysport for blepharospasm, cervical dystonia, and hemifacial spasm dystonia, and hemifacial spasm
    Katalin Bihari
    Institute of Neurosurgery, Budapest, Hungary
    Curr Med Res Opin 21:433-8. 2005
    Local injection of botulinum toxin type A is first-line treatment of blepharospasm, cervical dystonia, and hemifacial spasm; however, there is uncertainty about the optimal dose of toxin for each indication as well as dose-conversion ..
  13. doi Upper lid orbicularis oculi muscle strip and sequential brow suspension with autologous fascia lata is beneficial for selected patients with essential blepharospasm
    B Patil
    Department of Ophthalmology, Queen s Medical Centre, Nottingham University, Nottingham, UK
    Eye (Lond) 23:1549-53. 2009
    Severe cases of blepharospasm resistant to botulinum toxin represent a challenging clinical problem...
  14. ncbi Assessment of blepharospasm surgery using an improved disability scale: study of 138 patients
    Damien Grivet
    Department of Ophthalmology, Bellevue Hospital, Saint Etienne, France
    Ophthal Plast Reconstr Surg 21:230-4. 2005
    To assess a new scale for grading functional disability in a series of patients operated on for blepharospasm resistant to treatment by botulinum toxin (BT) injections.
  15. pmc Transcranial magnetic brain stimulation modulates blepharospasm: a randomized controlled study
    G Kranz
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 75:1465-71. 2010
    Benign essential blepharospasm (BEB) is a common form of focal dystonia. Besides pathology in the basal ganglia, accumulating evidence suggests pathologic changes in the anterior cingulate cortex (ACC).
  16. ncbi Comparison of two different formulations of botulinum toxin A for the treatment of blepharospasm and hemifacial spasm
    Chuan Jie Wu
    The First Affiliated Hospital of Zhengzhou University, Department of Neurology, Zhengzhou, China
    Turk Neurosurg 21:625-9. 2011
    ..CA, USA) in the treatment of blepharospasm (BS) and hemifacial spasm (HFS).
  17. ncbi Efficacy and safety of a new Botulinum Toxin Type A free of complexing proteins in the treatment of blepharospasm
    P Roggenkämper
    Department of Ophthalmology, University of Bonn, Wiesbaden, Germany
    J Neural Transm 113:303-12. 2006
    ..Phase III trial, we compared the efficacy and safety of NT 201 and BOTOX in patients suffering from blepharospasm. Of 304 enrolled patients, 300 patients received study medication (intent-to-treat population), and 256 ..
  18. doi Upper eyelid myectomy in blepharospasm with associated apraxia of lid opening
    Dan Georgescu
    Moran Eye Center, University of Utah, Salt Lake City, Utah 84102, USA
    Am J Ophthalmol 145:541-547. 2008
    To assess the impact of upper eyelid myectomy surgery on blepharospasm with associated apraxia of lid opening (ALO), dry eye, photophobia, and daily functioning in patients who are refractory to botulinum toxin treatment.
  19. doi Cognitive disturbances in primary blepharospasm
    Gabriela Gonzalez Alemán
    Parkinson s Disease and Movement Disorders Program, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Mov Disord 24:2112-20. 2009
    ..However, no systematic cognitive performance evaluation has been carried out in patients with primary blepharospasm (BS), one of the most common forms of adult dystonia...
  20. doi The phenomenology of the geste antagoniste in primary blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 25:407-12. 2010
    ..a representative clinical series of patients with the two most common forms of adult-onset primary dystonia, blepharospasm (BSP) and cervical dystonia (CD)...
  21. ncbi Effectivity of Dysport in patients with blepharospasm and hemifacial spasm who experienced failure with Botox
    Samih Badarny
    Movement Disorders Clinic, Neurology Department, Lady Davis Carmel Medical Center, Haifa, Israel
    Isr Med Assoc J 10:520-2. 2008
    ..Primary therapy failure with botulinum toxin is less common and poorly understood...
  22. ncbi Quality of life in patients with blepharospasm
    O Tucha
    Department of Neuropsychology, University of Regensburg, Germany
    Acta Neurol Scand 103:49-52. 2001
    OBJECTIVES: Administration of botulinum neurotoxin A (BONT/A) is a common and effective treatment of blepharospasm. There is, however, no information regarding the emotional and social well-being of patients with blepharospasm and ..
  23. ncbi The control of blepharospasm by essential fatty acids
    D I Mostofsky
    Psychopharmacology Laboratory, Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Neuropsychobiology 41:154-7. 2000
    ..This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders...
  24. ncbi Familial blepharospasm is inherited as an autosomal dominant trait and relates to a novel unassigned gene
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 18:207-12. 2003
    b>Blepharospasm (BSP) is a common form of primary torsion dystonia (PTD). Although most cases are sporadic, an increased familial incidence of BSP has been reported. Precisely how blepharospasm is inherited remains unclear...
  25. doi Gray matter density increase in the primary sensorimotor cortex in long-term essential blepharospasm
    Yukihisa Suzuki
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Neuroimage 56:1-7. 2011
    In this study, we investigated gray matter density in essential blepharospasm (EB) patients, focusing on the duration of disease and severity of symptoms. We studied 32 patients (10 males and 22 females; age, 55.0 ± 6...
  26. ncbi Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm
    Jordi Clarimon
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 22:162-6. 2007
    Primary blepharospasm is a common adult-onset focal dystonia. Polymorphisms of the genes encoding TorsinA (DYT1) and the D5 dopamine receptor (DRD5) have previously been associated with lifetime risk for focal dystonia...
  27. ncbi Quantitative changes in botulinum toxin a treatment over time in patients with essential blepharospasm and idiopathic hemifacial spasm
    Moshe Snir
    Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Tel Aviv, Israel
    Am J Ophthalmol 136:99-105. 2003
    To evaluate the quantitative changes in botulinum toxin A (BTA) treatment required over time to achieve relief for 3 to 4 months in patients with essential blepharospasm (EBS) and idiopathic hemifacial spasm (IHFS).
  28. ncbi Low-dose botulinum toxin a for treatment of blepharospasm and hemifacial spasm
    Anuchit Poonyathalang
    Jpn J Ophthalmol 49:327-8. 2005
  29. ncbi Botulinum toxin in blepharospasm and oromandibular dystonia: comparing different botulinum toxin preparations
    R Bhidayasiri
    Division of Neurology, Chulalongkorn University Hospital, Bangkok, Thailand
    Eur J Neurol 13:21-9. 2006
    ..Whilst blepharospasm--involuntary bilateral eye closure--is produced by spasmodic contractions of the orbicularis oculi muscles, ..
  30. ncbi Positron emission tomography scanning in essential blepharospasm
    John B Kerrison
    Department of Ophthalmology, Wilford Hall Medical Center, Lackland AFB, Lackland, Texas, USA
    Am J Ophthalmol 136:846-52. 2003
    To localize in the brain using positron emission tomography neuroimaging with (18)fluorodeoxyglucose [PET ((18)FDG)] differences in glucose metabolism between patients with essential blepharospasm (EB) and controls.
  31. pmc The blink reflex recovery cycle differs between essential and presumed psychogenic blepharospasm
    P Schwingenschuh
    UCL Institute of Neurology, London WC1N 3BG, UK
    Neurology 76:610-4. 2011
    Psychogenic blepharospasm is difficult to distinguish clinically from benign essential blepharospasm (BEB). The blink reflex recovery cycle measures the excitability of human brainstem interneurons and is abnormal in BEB...
  32. doi Cortical gray matter changes in primary blepharospasm: a voxel-based morphometry study
    Davide Martino
    Neurological Section, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 26:1907-12. 2011
    Previous voxel-based morphometry studies of patients with primary blepharospasm documented gray matter volumetric differences of the striatum, cerebellum, thalamus, and parietal lobe areas...
  33. ncbi Lack of effect of botulinum toxin on cortical excitability in patients with cranial dystonia
    Nasser Allam
    Movement Disorders Unit, Hospital de Base do Distrito Federal, Brasilia, DF, Brazil
    Clin Neuropharmacol 28:1-5. 2005
    ..BTX injection improved blepharospasm in all patients...
  34. doi Photophobia in essential blepharospasm--a positron emission tomographic study
    Hirofumi Emoto
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mov Disord 25:433-9. 2010
    To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis...
  35. pmc Blepharospasm and the modulation of cortical excitability in primary and secondary motor areas
    G Kranz
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 73:2031-6. 2009
    Traditionally, benign essential blepharospasm (BEB) is considered a disorder caused by basal ganglia dysfunction...
  36. pmc The TOR1A polymorphism rs1182 and the risk of spread in primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Policlinico, Piazza Giulio Cesare, Bari 1 70124, Italy
    Mov Disord 24:613-6. 2009
    ..TOR1A gene on the risk of dystonia spread in two representative cohorts of patients presenting with primary blepharospasm (BSP), one from Italy and the other from the United States of America...
  37. pmc Dry eye, blinking, and blepharospasm
    Craig Evinger
    Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, New York 11794, USA
    Mov Disord 17:S75-8. 2002
  38. ncbi Botulinum toxin for blepharospasm and hemifacial spasm: stability of duration of effect and dosage over time
    G T Drummond
    Pediatric Ophthalmology and Adult Strabismus Unit, University of Alberta, Edmonton
    Can J Ophthalmol 36:398-403. 2001
    ..METHODS: We reviewed the charts of 28 patients (17 with benign essential blepharospasm and 11 with hemifacial spasm) seen between 1989 and 1994 by one ophthalmologist at the botulinum clinic at a ..
  39. ncbi Pathophysiology and treatment of cranial dystonia
    Alfredo Berardelli
    Department of Neurological Sciences, University of Rome La Sapienza and Istituto Neurologico Mediterraneo Neuromed, IRCCS, Pozzilli, Italy
    Mov Disord 17:S70-4. 2002
  40. doi Fifteen-year experience in treating blepharospasm with Botox or Dysport: same toxin, two drugs
    A R Bentivoglio
    Istituto di Neurologia Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8 00168 Rome, Italy
    Neurotox Res 15:224-31. 2009
    To compare the clinical characteristics and the long-term outcome of a large series of patients with blepharospasm (BS) treated with the two most used brands of BoNT-A over the last 15 years.
  41. ncbi Bell's palsy-induced blepharospasm
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Neurol 249:452-4. 2002
    We report two patients with blepharospasm that appeared during the recovery phase of Bell's palsy...
  42. ncbi Evidence of widespread impairment of motor cortical inhibition in focal dystonia: a transcranial magnetic stimulation study in patients with blepharospasm and cervical dystonia
    Raif Cakmur
    Department of Neurology, Dokuz Eylul University, Medical School, Izmir, Turkey
    Adv Neurol 94:37-44. 2004
  43. ncbi Long-term efficacy of botulinum a toxin for blepharospasm and hemifacial spasm
    Harmeet S Gill
    Department of Ophthalmology and Vision Sciences, University Health Network and the University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 37:631-6. 2010
    To determine whether the duration of relief from symptoms in patients with essential blepharospasm (EB) or hemifacial spasm (HFS) who receive serial treatments with botulinum toxin type A (BtA) changes over the long-term.
  44. ncbi Prevalence of primary blepharospasm in Sardinia, Italy: a service-based survey
    Giovanni Cossu
    Neurology Service and Stroke Unit, General Hospital S Michele AOB G Brotzu, Cagliari, Sardinia, Italy
    Mov Disord 21:2005-8. 2006
    We performed a service-based epidemiological study of primary blepharospasm in the island of Sardinia (Italy)...
  45. ncbi Improvement of blepharospasm with Zolpidem
    Nélida Susana Garretto
    Movement Disorders Clinic, Department of Neurology, J M Ramos Mejia Hospital, Buenos Aires, Argentina
    Mov Disord 19:967-8. 2004
    Zolpidem (ZLP) is an imidazopyridine that binds to GABA receptors. We report on improvement of blepharospasm in 3 patients treated with ZLP...
  46. ncbi Health-related quality of life and psychosocial characteristics of patients with benign essential blepharospasm
    Tyler Andrew Hall
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Suite 609, 700 S 18th Street, Birmingham, AL 35294 0009, USA
    Arch Ophthalmol 124:116-9. 2006
    To examine vision-targeted health-related quality of life and psychosocial characteristics in patients with benign essential blepharospasm (BEB) compared with patients with hemifacial spasm (HFS).
  47. ncbi Enhanced long-term potentiation-like plasticity of the trigeminal blink reflex circuit in blepharospasm
    Angelo Quartarone
    Department of Neurosciences, University of Messina, 98125 Messina, Italy
    J Neurosci 26:716-21. 2006
    Benign essential blepharospasm (BEB) is a focal cranial dystonia affecting eye closure. Here, we tested the hypothesis that BEB is associated with abnormal plasticity of the neuronal circuits mediating reflex blinks...
  48. doi Efficacy and safety of incobotulinumtoxinA (NT 201, Xeomin) in the treatment of blepharospasm-a randomized trial
    Joseph Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 26:1521-8. 2011
    ..up to 50 U per eye) to placebo administered in a single treatment session to patients with blepharospasm. All patients had documented satisfactory response to 2 previous treatments with botulinum neurotoxin type A ..
  49. doi Long-term efficacy of botulinum toxin A for treatment of blepharospasm, hemifacial spasm, and spastic entropion: a multicentre study using two drug-dose escalation indexes
    S Cillino
    Dipartimento Universitario di Neuroscienze Cliniche, Sezione di Oftalmologia, Universita degli Studi di Palermo, Palermo, Italy
    Eye (Lond) 24:600-7. 2010
    ..the long-term effectiveness and safety of botulinum neurotoxin A (BoNT-A) treatment in patients with blepharospasm (BEB), hemifacial spasm (HFS), and entropion (EN) and to use for the first time two modified indexes, 'botulin ..
  50. ncbi Comparison of preseptal and pretarsal injections of botulinum toxin in the treatment of blepharospasm and hemifacial spasm
    Raif Cakmur
    Dokuz Eylul Universitesi, Tip Fakultesi, Noroloji Klinigi, Inciralti Izmir, Turkey
    J Neurol 249:64-8. 2002
    ..the beneficial effect of subcutaneous injections of botulinum toxin type A (BTX-A) is well known in both blepharospasm and hemifacial spasm, the position of the injection sites around the orbicularis oculi may influence the ..
  51. ncbi Retrospective evaluation of the dose of Dysport and BOTOX in the management of cervical dystonia and blepharospasm: the REAL DOSE study
    Albert Marchetti
    Thomson Health Economics Research, Secaucus, New Jersey, USA
    Mov Disord 20:937-44. 2005
    ..of this study is to evaluate the real-world dose utilization of Dysport and BOTOX for cervical dystonia and blepharospasm. Six investigational sites (five countries) were identified...
  52. ncbi Health-related quality of life in blepharospasm or hemifacial spasm
    J Reimer
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg
    Acta Neurol Scand 111:64-70. 2005
    ..Health-related quality of life (HRQL) has become an important outcome criterion of medical interventions, but was hardly studied in patients with facial spasms...
  53. ncbi Silent event-related fMRI reveals deficient motor and enhanced somatosensory activation in orofacial dystonia
    Christian Dresel
    Department of Neurology, Neurologisches Krankenhaus Muenchen, Germany
    Brain 129:36-46. 2006
    ..We used a whistling task and silent event-related fMRI to investigate functional changes in patients with blepharospasm and patients with a combination of blepharospasm and oromandibular dystonia (Meige's syndrome)...
  54. ncbi A new grading system for assessing orbicularis muscle function
    R Rahman
    The Royal Eye Infirmary, Plymouth, UK
    Eye (Lond) 17:610-2. 2003
    To establish an objective parameter (orbicularis function) to measure the efficacy of botulinum toxin treatment in weakening the orbicularis of blepharospasm and hemifacial spasm sufferers.
  55. doi Electrical activation of the orbicularis oculi muscle does not increase the effectiveness of botulinum toxin type A in patients with blepharospasm
    A Conte
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Eur J Neurol 17:449-55. 2010
    ..activation of the injected muscle increases effectiveness of botulinum type A toxin (BonT-A) in patients with blepharospasm (BPS)...
  56. ncbi A functional magnetic resonance imaging study in patients with benign essential blepharospasm
    Robert S Baker
    Department of Ophthalmology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroophthalmol 23:11-5. 2003
    ..blinking-induced functional magnetic resonance imaging (fMRI) activation patterns in five benign essential blepharospasm (BEB) patients and five age-matched control subjects...
  57. doi Videonystagmography as a tool to assess blepharospasm before and after botulinum toxin injection
    Guillaume Casse
    Ophthalmology Department, CHU Dupuytren, 2 Av Martin Luther King, 87042 Limoges Cedex, France
    Graefes Arch Clin Exp Ophthalmol 246:1307-14. 2008
    The aim of this paper was to study blinking parameters using a videonystagmography device, in order to objectively determine disability, and to assess the efficiency of botulinum toxin injection in patients with essential blepharospasm.
  58. doi Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasm
    G Fabbrini
    Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
    Eur J Neurol 15:185-9. 2008
    ..We studied 18 patients with cervical dystonia (CD), 16 with blepharospasm (BSP) and 35 years age-matched healthy controls. DTI data were obtained with a Philips 1...
  59. doi Videonystagmography to assess eyelid dynamic disorders
    Guillaume Casse
    Ophthalmology Department, CHU Dupuytren, Cedex, France
    Orbit 28:20-4. 2009
    Apply a videonystagmography (VNG) device to study indirectly blinking in patients with essential blepharospasm.
  60. ncbi Tactile temporal discrimination in patients with blepharospasm
    M Fiorio
    Dipartimento di Scienze Neurologiche e della Visione, Sez Neurologia Riabilitativa, Universitè di Verona, Via Casorati 43, 37131 Verona, Italy
    J Neurol Neurosurg Psychiatry 79:796-8. 2008
    b>Blepharospasm is an adult-onset focal dystonia that causes involuntary blinking and eyelid spasms. Studies have shown the presence of sensory deficits associated with dystonia.
  61. doi Clinical efficacy and tolerability of Xeomin in the treatment of blepharospasm
    J Jankovic
    Department of Neurology, Parkinson s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Neurol 16:14-8. 2009
    b>Blepharospasm is classified as a focal dystonia, and botulinum toxin type A (BoNT/A) has been shown to be a highly effective and well-tolerated symptomatic treatment...
  62. doi High versus low concentration botulinum toxin A for benign essential blepharospasm: does dilution make a difference?
    Michael H Boyle
    Alabama Ophthalmology Associates, P C, Division of Ophthalmic Plastic and Reconstructive Surgery, Birmingham, Alabama, USA
    Ophthal Plast Reconstr Surg 25:81-4. 2009
    To evaluate the efficacy and side effects of concentrated versus dilute botulinum toxin A in treating benign essential blepharospasm.
  63. pmc Double-blind, randomized, comparative study of Meditoxin versus Botox in the treatment of essential blepharospasm
    Jin Sook Yoon
    Department of Ophthalmology, Institute of Vision Research, University of Yonsei, Seoul, Korea
    Korean J Ophthalmol 23:137-41. 2009
    To compare the efficacies and safeties of Meditoxin (Medy-Tox, Korea) and Botox in the treatment of essential blepharospasm.
  64. doi Prospective, randomized, double-blind study, comparing botulinum toxins type a botox and prosigne for blepharospasm and hemifacial spasm treatment
    Elizabeth Maria Aparecida Barasnevicius Quagliato
    Neurology Department, Faculdade de Ciencias Medicas da Universidade Estadual de Campinas, Sao Paulo, Brazil
    Clin Neuropharmacol 33:27-31. 2010
    Botulinum toxin A (BTA) is considered an effective treatment of blepharospasm and hemifacial spasm, but there are few studies to permit a comparison of its different formulations...
  65. ncbi Headache and facial pain responsive to botulinum toxin: an unusual presentation of blepharospasm
    S J Johnstone
    Department of Neurology, Barrow Neurologic Institute, Phoenix, AZ 85013, USA
    Headache 38:366-8. 1998
    The diagnosis of blepharospasm is rarely considered in patients complaining of face pain or headache...
  66. doi Efficacy and safety of purified botulinum toxin type A (Dysport) for the treatment of benign essential blepharospasm: a randomized, placebo-controlled, phase II trial
    Daniel Truong
    The Parkinson s and Movement Disorder Institute, Orange Coast Memorial Medical Center, 9940 Talbert Ave 204, Fountain Valley, CA 92708, USA
    Parkinsonism Relat Disord 14:407-14. 2008
    The majority of studies on the effects of botulinum toxin in blepharospasm patients have been small or unblinded...
  67. ncbi Co-occurence of blepharospasm, tourettism and obsessive-compulsive symptoms during lamotrigine treatment
    Tunc Alkin
    Prog Neuropsychopharmacol Biol Psychiatry 31:1339-40. 2007
  68. ncbi Benign essential blepharospasm
    Guy J Ben Simon
    Jules Stein Eye Institute, Room 2 267, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Int Ophthalmol Clin 45:49-75. 2005
  69. ncbi Botulinum toxin a in the treatment of blepharospasm: a 10-year experience
    Laura Silveira-Moriyama
    Movement Disorders Clinic of the Department of Neurology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo SP, Brazil HC FMUSP
    Arq Neuropsiquiatr 63:221-4. 2005
    To evaluate the long-term effect of botulinum toxin type A (BTX) in the treatment of blepharospasm, a retrospective analysis was conducted from the patients seen at the Movement Disorders Clinic of the Department of Neurology, Hospital ..
  70. ncbi Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening
    Robert Forget
    Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain, Institut de Réadaptation de Montréal, Qué H3S 2J4, Canada
    Neurology 58:1843-6. 2002
    ..EMG of the orbicularis oculi (OOc) were analyzed in 10 patients with apraxia of lid opening associated with blepharospasm before and after botulinum toxin treatment...
  71. ncbi Supramaximal doses of botulinum toxin for refractory blepharospasm
    Richard L Levy
    Neuro Ophthalmology Unit, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ophthalmology 113:1665-8. 2006
    To investigate the response to supramaximal doses of botulinum toxin in patients with refractory blepharospasm.
  72. pmc Bilateral grey-matter increase in the putamen in primary blepharospasm
    T Etgen
    Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1017-20. 2006
    Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids. The pathophysiology of primary blepharospasm is unresolved.
  73. ncbi A double-blind, randomized, crossover study of prosigne versus botox in patients with blepharospasm and hemifacial spasm
    Carlos R M Rieder
    Department of Neurology, Hospital de Clinicas de Porto Alegre, Brazil
    Clin Neuropharmacol 30:39-42. 2007
    ..The aim of our study was to compare the efficacy and safety of Prosigne in the treatment of blepharospasm and hemifacial spasm in comparison to Botox...
  74. ncbi Botulinum toxin in the treatment of blepharospasm and hemifacial spasm
    C Kenney
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neural Transm 115:585-91. 2008
    b>Blepharospasm and hemifacial spasm are the two most common craniofacial movement disorders...
  75. pmc A family study on primary blepharospasm
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 77:252-4. 2006
    Previous family studies provided evidence that blepharospasm (BSP) can aggregate in families but did not give accurate and reliable information on the characteristics and degree of familial clustering.
  76. ncbi Botulinum toxin: evidence-based medicine criteria in blepharospasm and hemifacial spasm
    W H Jost
    Department of Neurology and Clinical Neurophysiology, Deutsche Klinik für Diagnostik Aukammallee 33 65191 Wiesbaden, Germany
    J Neurol 248:21-4. 2001
    Botulinum A toxin is recognized and approved for symptomatic treatment of hemifacial spasm and blepharospasm. The state of trials is good, although double-blind placebo-controlled studies have been carried out involving only a small ..
  77. ncbi The stimulus intensity modifies the blink reflex recovery cycle in healthy subjects and in blepharospasm
    M Sommer
    Department of Clinical Neurophysiology, Center for Neurological Medicine, , , Germany
    Clin Neurophysiol 112:2293-9. 2001
    ..excitability of human brainstem interneurons is measured by the blink reflex recovery cycle and is abnormal in blepharospasm. We wondered whether the results of this paradigm depend on the stimulus intensity...
  78. pmc Botulinum toxin type B in blepharospasm and hemifacial spasm
    C Colosimo
    J Neurol Neurosurg Psychiatry 74:687. 2003
  79. ncbi A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm
    A Misbahuddin
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Neurology 58:124-6. 2002
    ..The authors performed a case-control allelic association study in patients with the focal dystonia blepharospasm, using polymorphisms in the dopamine receptor and transporter genes...
  80. ncbi Epidemiology of primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    Mov Disord 17:7-12. 2002
    We review epidemiological data on primary blepharospasm (BSP). There is a large variation in the stated prevalence of BSP, with crude estimates ranging from 16 to 133 per million in different studies...
  81. ncbi Bell's palsy-induced blepharospasm relieved by passive eyelid closure and responsive to apomorphine
    Luigi Cattaneo
    Dipartimento di Neuroscienze, Sezione di Neurologia, Universita degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy
    Clin Neurophysiol 116:2348-53. 2005
    We describe the case of a woman with Bell's Palsy-induced blepharospasm (BPIB) of the right eye that appeared simultaneously with a complete left facial nerve palsy...
  82. ncbi Clozapine-induced tardive dystonia (blepharospasm)
    Harpreet S Duggal
    J Neuropsychiatry Clin Neurosci 19:86-7. 2007
  83. pmc Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye
    J Horwath-Winter
    Department of Ophthalmology, Auenbruggerplatz 4, A 8036 Graz, Austria
    Br J Ophthalmol 87:54-6. 2003
    Many patients with essential blepharospasm also show dry eye signs and symptoms. Botulinum toxin A is an effective treatment for reducing spasms in these patients...
  84. ncbi Striatal activation during blepharospasm revealed by fMRI
    Kerstin E Schmidt
    Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt Main, Germany
    Neurology 60:1738-43. 2003
    To investigate brain areas involved in the initiation and execution of eyelid spasm in patients with benign essential blepharospasm.
  85. doi Environmental risk factors and clinical phenotype in familial and sporadic primary blepharospasm
    G Defazio
    Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Neurology 77:631-7. 2011
    Although environmental and genetic factors may contribute to the etiology of blepharospasm, their relative contribution in causing familial and sporadic blepharospasm is unknown.
  86. ncbi Glucose hypermetabolism in the thalamus of patients with essential blepharospasm
    Yukihisa Suzuki
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol 254:890-6. 2007
    Essential blepharospasm (EB) is classified as a form of focal dystonia characterized by involuntary spasms of the musculature of the upper face. The basic neurological process causing EB is not known...
  87. ncbi Treatment of blepharospasm with botulinum neurotoxin type A: long-term results
    P Calace
    Department of Ophthalmologic Sciences, Faculty of Medicine and Surgery, University Federico II, Napoli, Italy
    Eur J Ophthalmol 13:331-6. 2003
    To describe the long-term efficacy and side effects of treatment of blepharospasm with botulinum neurotoxin type A (Botox).
  88. ncbi A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome
    Susan Vitale
    Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Ophthalmol 138:18-32. 2004
    To evaluate the effectiveness of super blue-green algae (SBGA) supplements on the severity of essential blepharospasm treated with botulinum toxin A injections.
  89. ncbi Blepharospasm associated with multiple system atrophy: a case report and review of the literature
    Maki Kagohashi
    Department of Neurology, Juntendo University Izu Nagaoka Hospital, 1129 Nagaoka, Izu Nagaoka, Tagata, Shizuoka 410 2295, Japan
    Parkinsonism Relat Disord 10:169-71. 2004
    Although blepharospasm has been occasionally associated with parkinsonism, it has rarely been reported in patients with multiple system atrophy (MSA)...
  90. pmc Etizolam and benzodiazepine induced blepharospasm
    M Wakakura
    J Neurol Neurosurg Psychiatry 75:506-7. 2004
  91. ncbi The evaluation of light sensitivity in benign essential blepharospasm
    Wesley H Adams
    Department of Ophthalmology and Visual Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Am J Ophthalmol 142:82-87. 2006
    To test light sensitivity thresholds rigorously in patients with benign essential blepharospasm (BEB) compared with patients who have known light sensitivity (migraineurs) and to normal control subjects.
  92. ncbi Venlafaxine and tardive blepharospasm: a case report
    Yu Lee
    Prog Neuropsychopharmacol Biol Psychiatry 31:1139-40. 2007
  93. ncbi Facial palsy-induced blepharospasm relieved by a Bangerter foil
    Suresh Sagili
    Mov Disord 20:1231-2. 2005
  94. ncbi Modulation of sensory photophobia in essential blepharospasm with chromatic lenses
    Natasha L Herz
    Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Ophthalmology 112:2208-11. 2005
    To determine the effect of photochromatic modulation with tinted lenses on the sensory symptoms of photophobia in blepharospasm patients.
  95. ncbi Botulinum toxin in movement disorders
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Semin Neurol 27:183-94. 2007
    ..However, controlled studies for many conditions are lacking, and more clinical trials in many different areas are warranted...
  96. ncbi Apraxia of eyelid opening: clinical features and therapy
    E Kerty
    Department of Neurology, Rikshospitalet, University Hospital, Oslo, Norway
    Eur J Ophthalmol 16:204-8. 2006
    Botulinum toxin injection is the treatment of choice in cases of benign essential blepharospasm. However, about 10% of the patients do not get sufficient effect from this treatment, and many of them have concomitant apraxia of lid opening.
  97. ncbi Morphometric changes of sensorimotor structures in focal dystonia
    Mark Obermann
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Mov Disord 22:1117-23. 2007
    Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia...
  98. ncbi [Essential blepharospasm and hemifacial spasm: characteristic of the patient, botulinum toxin A treatment and literature review]
    Silvana Artioli Schellini
    Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Julio Mesquita Filho, Botucatu, SP, Brazil
    Arq Bras Oftalmol 69:23-6. 2006
    To evaluate the characteristics of the essential blepharospasm and hemifacial spasm patients and the feasible treatment with botulinum toxin A.
  99. ncbi Dystonia and headaches: clinical features and response to botulinum toxin therapy
    Nestor Galvez-Jimenez
    Movement Disorders, Department of Neurology, Cleveland Clinic Florida, Weston, Florida, USA
    Adv Neurol 94:321-8. 2004
  100. ncbi Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases
    Masato Kanazawa
    Mov Disord 22:597-8. 2007
  101. ncbi [Botulism toxin in practice]
    A Durand
    Faculte de Pharmacie, 27, Boulevard Jean Moulin, 13005 Marseille, France
    Ann Readapt Med Phys 46:386-8. 2003
    ..The respective formulations of Botox, Dysport and Neurobloc are described. Special considerations for administration are introduced...

Research Grants25

  1. EYELID SENSORIMOTOR NETWORKS
    Mark leDoux; Fiscal Year: 2003
    ..Disorders of the nervous system associated with abnormal blinking such as blepharospasm and apraxia of eyelid opening can produce significant functional disability including blindness...
  2. Dystonia Coalition
    Hyder A Jinnah; Fiscal Year: 2013
    ..approximately 80% of all dystonias: cervical dystonia (torticollis), laryngeal dystonia (spasmodic dysphonia), blepharospasm (peri-ocular regions), craniofacial dystonia (upper and lower face), and limb dystonias (hand/arm or foot/leg)...
  3. Kinaesthetic Loss as a Marker for Spasmodic Dysphonia
    Peter J Watson; Fiscal Year: 2012
    ..Recent research documented that patients with focal dystonia affecting head and neck musculature, such as blepharospasm and torticollis, reveal kinaesthetic deficits in the non-dystonic musculature of their upper limbs suggesting ..
  4. Mesenchymal Stem Cell Therapy for Corneal Cystinosis
    JENNIFER LYNNE SIMPSON; Fiscal Year: 2013
    ..In the cornea, progressive visual deterioration due to photophobia, blepharospasm and recurrent corneal erosions are associated with increasing concentrations of corneal crystals and are a ..
  5. A Cell-based Assay for Botulinum Neurotoxin Detection and Development
    Ward C Tucker; Fiscal Year: 2013
    ..and are currently FDA-approved for treating glabellar lines (wrinkles), cervical dystonia, chronic migraines, blepharospasm, cranial nerve VII disorders, and cosmoses...
  6. Diagnostic Error in Dystonia
    Caroline M Tanner; Fiscal Year: 2010
    ..Common subtypes of primary dystonia include dystonic blepharospasm, spasmodic torticollis, oromandibular dystonia, spasmodic dysphonia and focal hand dystonia (writer's ..
  7. CONTROL OF EYELIDS IN NORMAL AND PATHOLOGICAL STATES
    LESLIE CRAIG EVINGER; Fiscal Year: 2011
    ..the previous grant period, we have investigated the neural basis of the focal dystonia, benign essential blepharospasm (BEB)...
  8. BOTULINUM NEUROTOXIN: MECHANISM OF TOXICITY
    BIBHUTI DASGUPTA; Fiscal Year: 1991
    ..g. blepharospasm, hemifacial spasm, and strabismus in human patients...
  9. MECHANISM OF BOTULINUM NEUROTOXIN ACTION
    Bal Ram Singh; Fiscal Year: 1999
    ..the neurotoxins are being used as therapeutic agents to treat several neuro- muscular diseases such as blepharospasm, strabismus, torticollis, etc., and have potential to be used for many more neuro-muscular disorders...
  10. CHEMOMYECTOMY FOR EYELID SPASMS
    Linda McLoon; Fiscal Year: 1999
    b>Blepharospasm, hemifacial spasm and other diseases involving forceful, uncontrolled muscle spasms of the face and neck are extremely debilitating conditions that result in functional blindness, often causing affected persons to withdraw ..
  11. A Cell-based Assay for Botulinum Neurotoxin Detection and Development
    Ward C Tucker; Fiscal Year: 2010
    ..and are currently FDA-approved for the treatment of glabellar lines (wrinkles), cervical dystonia, blepharospasm, cranial nerve VII disorders, and cosmoses...
  12. NEUROIMAGING OF HYPERKINETIC MOVEMENT DISORDERS
    Michael Hutchinson; Fiscal Year: 2001
    ..hyperkinetic disorders will be studied using regional measures of cerebral glucose metabolism and blood flow: blepharospasm, idiopathic torsion dystonia, Huntington's chorea and levodopa-induced dyskinesia...
  13. A Novel Immunotoxin for Treatment and Cure of Strabismus
    LEO CHALUPA; Fiscal Year: 2005
    ..The use of IX-146 could be extended in the future to a wider variety of ophthalmologic, neurologic, and neuromuscular disorders, including blepharospasm as well as other types of dystonias.
  14. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 2000
    ..dystrophy and myasthenia gravis, the results of these investigations will be important for other disorders of extraocular muscle, such as strabismus, genetic ocular motility disorders, congenital myasthenic syndromes, and blepharospasm.
  15. IMMUNOTOXIN TREATMENT OF BLEPHAROSPASM AND STRABISMUS
    THOMAS WALLACE; Fiscal Year: 1992
    b>Blepharospasm and strabismus are chronic, debilitating, ocular spastic disorders caused by uncontrolled or unbalanced muscle contraction...
  16. Phase Dynamics in a Brainstem Sensorimotor Feedback Loop
    Quoc Thang Nguyen; Fiscal Year: 2006
    ..Our research could provide clues to understand the still unknown etiology of diseases such as blepharospasm.
  17. EYELID KINEMATICS IN HEALTH AND DISEASE
    Robert Baker; Fiscal Year: 2001
    ..Second, data from the current project period support the hypothesis that blepharospasm results from an interaction orf corneal irritation and/or weakness of eyelid closure with compromised adaptive ..
  18. CLINICAL CHARACTERIZATION&GENETICS OF OPTIC NERVE DRUSEN
    Bradley Katz; Fiscal Year: 2005
    ..These data may suggest novel therapies to prevent the visual field loss associated with OND. In addition, these data may yield information about other diseases of the optic nerve. ..
  19. SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
    Alan Scott; Fiscal Year: 2002
    ..Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal. ..
  20. Assessment of Quality of Life in Graves' Ophthalmopathy
    Elizabeth Bradley; Fiscal Year: 2006
    ..These efforts will serve as important preparatory steps toward Dr. Bradley's long-term goal of studying treatments of Graves' opthalmopathy through medical and surgical clinical trials. ..
  21. GENETICS OF PARKINSON DISEASE IN THE AMISH
    Brad Racette; Fiscal Year: 2006
    ..abstract_text> ..
  22. Molecular Foundations of the Myoclonus-Dystonia Syndrome
    Mark leDoux; Fiscal Year: 2006
    ..We hypothesize that epsilon sarcoglycan co-localizes with GABA receptors opposite GABAergic terminals in the central nervous system. ..
  23. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  24. Mutant Gene Identification in the Dystonic Rat
    Mark leDoux; Fiscal Year: 2008
    ..Patients with dystonia will be screened for mutations in the human homologue. These proposed studies will likely increase our understanding of both dystonia and olivocerebellar motor systems. ..
  25. TETRAHYDROISOQUINOLINES AND PARKINSON'S DISEASE
    Mark leDoux; Fiscal Year: 2006
    ..Evolution may have not provided neurons with mechanisms to prevent accumulation of these by-products of normal metabolism and, as a consequence, susceptible neuronal populations may slowly undergo apoptotic death in the elderly. ..