uveal neoplasms

Summary

Summary: Tumors or cancer of the UVEA.

Top Publications

  1. pmc Mutations in GNA11 in uveal melanoma
    Catherine D Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    N Engl J Med 363:2191-9. 2010
  2. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010
  3. pmc Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    Catherine D Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada
    Nature 457:599-602. 2009
  4. doi Uveal melanoma: trends in incidence, treatment, and survival
    Arun D Singh
    Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ophthalmology 118:1881-5. 2011
  5. doi Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma
    Xiaoyan Chen
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 52:1193-9. 2011
  6. doi MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Invest Ophthalmol Vis Sci 50:1559-65. 2009
  7. ncbi Very long-term prognosis of patients with malignant uveal melanoma
    Emma Kujala
    Ocular Oncology Service, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Invest Ophthalmol Vis Sci 44:4651-9. 2003
  8. doi Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells
    Mao Ye
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Invest Ophthalmol Vis Sci 49:497-504. 2008
  9. pmc Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:2835-42. 2010
  10. doi Detection of M2-macrophages in uveal melanoma and relation with survival
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 52:643-50. 2011

Research Grants

  1. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
  2. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre Triozzi; Fiscal Year: 2007
  3. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre Triozzi; Fiscal Year: 2009
  4. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
  5. Uveal Melanoma Micrometastasis
    Pierre L Triozzi; Fiscal Year: 2010
  6. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2004
  7. MICROCIRCULATION OF UVEAL MELANOMA
    Robert Folberg; Fiscal Year: 2002
  8. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2009
  9. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
  10. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2007

Detail Information

Publications237 found, 100 shown here

  1. pmc Mutations in GNA11 in uveal melanoma
    Catherine D Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    N Engl J Med 363:2191-9. 2010
    ..Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas...
  2. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010
    ..These findings implicate loss of BAP1 in uveal melanoma metastasis and suggest that the BAP1 pathway may be a valuable therapeutic target...
  3. pmc Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    Catherine D Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada
    Nature 457:599-602. 2009
    ..Our results demonstrate an alternative route to MAP kinase activation in melanocytic neoplasia, providing new opportunities for therapeutic intervention...
  4. doi Uveal melanoma: trends in incidence, treatment, and survival
    Arun D Singh
    Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ophthalmology 118:1881-5. 2011
    ..To determine trends in incidence, treatment, and survival with primary uveal melanoma in the United States over a 36-year period from 1973 to 2008...
  5. doi Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma
    Xiaoyan Chen
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 52:1193-9. 2011
    ..The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. In this study, they investigated the role of miR-137 in the pathogenesis of uveal melanoma...
  6. doi MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Invest Ophthalmol Vis Sci 50:1559-65. 2009
    ..MicroRNA-34a (miR-34a), a potential key effector of the p53 tumor-suppressor gene, was studied as a potential tumor suppressor in uveal melanoma...
  7. ncbi Very long-term prognosis of patients with malignant uveal melanoma
    Emma Kujala
    Ocular Oncology Service, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Invest Ophthalmol Vis Sci 44:4651-9. 2003
    ..To investigate the very long-term prognosis of patients with uveal melanoma and the clinical characteristics influencing it...
  8. doi Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells
    Mao Ye
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Invest Ophthalmol Vis Sci 49:497-504. 2008
    ..This study investigated the effect of hepatocyte growth factor (HGF)-triggered signaling pathways to identify the role of HGF and its downstream effectors in inducing the migration of uveal melanoma cells...
  9. pmc Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:2835-42. 2010
    ..This study was undertaken to determine whether anti-vascular endothelial growth factor (VEGF) therapy inhibits growth of primary uveal melanoma and spread of its hepatic micrometastases...
  10. doi Detection of M2-macrophages in uveal melanoma and relation with survival
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 52:643-50. 2011
    ..This study was conducted to determine whether the tumor-infiltrating macrophages in uveal melanoma are of this M2 subtype...
  11. pmc Vasculogenic mimicry and tumor angiogenesis
    R Folberg
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA
    Am J Pathol 156:361-81. 2000
    ..The unique patterning characteristic of vasculogenic mimicry provides an opportunity to design noninvasive imaging techniques to detect highly aggressive neoplasms and their metastases...
  12. doi The miRNA expression profile of the uveal melanoma
    Chenghsun Yang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing 100730, China
    Sci China Life Sci 54:351-8. 2011
    ..The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis, and may help promote the diagnosis and treatment for uveal melanoma...
  13. doi Targeted therapy for uveal melanoma
    Pierre L Triozzi
    Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, United States
    Cancer Treat Rev 34:247-58. 2008
    ..Clinical trials of some of these approaches have been initiated in patients with metastatic uveal melanoma as well as in the adjuvant setting after primary therapy...
  14. doi Functional significance of B7-H1 expressed by human uveal melanoma cells
    Renbing Jia
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, PR China
    Mol Med Rep 4:163-7. 2011
    ..This provides new insight into anti-tumor immunity against B7-H1-expressing UM cells...
  15. pmc Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window
    S R Boyd
    Department of Pathology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Br J Ophthalmol 86:448-52. 2002
    ..Novel anti-VEGF therapies are now in clinical trial, and the authors therefore wished to determine whether VEGF-A was indeed elevated in melanoma bearing eyes...
  16. doi High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients
    Cecile Laurent
    Institut Curie, Paris, France
    Cancer Res 71:666-74. 2011
    ..Our findings suggest that PTP4A3 or its cellular substrates could constitute attractive therapeutic targets to treat metastatic uveal melanomas...
  17. doi Effectiveness of treatments for metastatic uveal melanoma
    James J Augsburger
    Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Am J Ophthalmol 148:119-27. 2009
    ..To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma...
  18. doi Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas
    Helena Pópulo
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Br J Ophthalmol 95:715-9. 2011
    ..To study the GNAQ mutational status in a series of uveal melanomas and evaluate possible associations with mitogen-activated protein kinase (MAPK) pathway protein expression and tumour proliferation markers...
  19. pmc An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Diagn 12:461-8. 2010
    ..This prognostic assay provides an important addition to the armamentarium for managing patients with uveal melanoma, and it provides a proof of principle for the development of similar assays for other cancers...
  20. doi The genetics of uveal melanoma: an emerging framework for targeted therapy
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 25:171-81. 2012
    ..These mutations appear to be key events that provide the potential for targeted therapy. This article will review the genetic findings in uveal melanoma over the past two decades and suggest important areas for future work...
  21. doi Combination of oncolytic adenovirus and dacarbazine attenuates antitumor ability against uveal melanoma cells via cell cycle block
    Biyun Cun
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Cancer Biol Ther 13:77-84. 2012
    ..Our study suggests the viro-chemo combination therapy is feasible and is a potentially promising approach for the treatment of uveal melanoma...
  22. doi Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 24:643-55. 2011
    ..These uveal melanoma cell lines might therefore prove particularly useful as cellular models to investigate α5β1 function in the pathogenesis of invasive uveal melanoma...
  23. ncbi Prognostic factors in uveal melanoma
    A D Singh
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA
    Melanoma Res 11:255-63. 2001
    ..At present, the role of these therapeutic methods is not clearly established...
  24. doi Notch signaling promotes growth and invasion in uveal melanoma
    Laura Asnaghi
    Department of Pathology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 18:654-65. 2012
    ..To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis...
  25. ncbi HLA expression in uveal melanoma: there is no rule without some exception
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 63:444-51. 2002
    ....
  26. doi Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis
    Shu Hong Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Melanoma Res 18:191-200. 2008
    ....
  27. doi Radiation-inducible human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy: a novel treatment for radioresistant uveal melanoma
    Yixiong Zhou
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Pigment Cell Melanoma Res 23:661-74. 2010
    ..01). Our findings indicate that radioresponsive gene therapy has the potential to be a more effective and specific therapy for UM because the therapeutic gene can be spatially or temporally controlled by exogenous radiation...
  28. ncbi Vascular endothelial growth factor a in eyes with uveal melanoma
    Guy S O Missotten
    Departments of Ophthalmology, Pathology, and Medical Statistics, Leiden University Medical Center, Leiden
    Arch Ophthalmol 124:1428-34. 2006
    ..To determine the presence of vascular endothelial growth factor A (VEGF-A) in the aqueous humor of eyes with uveal melanoma and to identify its source...
  29. doi Expression of CD133 and other putative stem cell markers in uveal melanoma
    Michelle Thill
    Department of Ophthalmology, Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Melanoma Res 21:405-16. 2011
    ..Further experiments are needed to isolate stem cell marker-positive cells, to evaluate their functional properties and to explore therapeutical approaches to these putative CSCs in uveal melanoma...
  30. pmc Authenticating cell lines in ophthalmic research laboratories
    Robert Folberg
    Oakland University William Beaumont School of Medicine, Rochester, Michigan 48309 4401, USA
    Invest Ophthalmol Vis Sci 49:4697-701. 2008
  31. pmc Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
    Aizhi Zhu
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 53:8556-68. 2010
    ..These data demonstrate that dipyrimidine amines are unique CXCR4 antagonists with high potency and specificity...
  32. doi P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma
    Lyndsay Davies
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    J Cell Mol Med 13:1995-2007. 2009
    ..The findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by UM tumours to modulate susceptibility to apoptosis...
  33. pmc Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
    J Bauer
    Department of Dermatology, University of Tübingen Medical Center, Liebermeisterstr 25, Tubingen 72076, Germany
    Br J Cancer 101:813-5. 2009
    ..Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and in the blue nevi of the skin...
  34. doi Regulation of VEGF-A in uveal melanoma
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 51:2329-37. 2010
    ..This study was undertaken to examine the regulation of the proangiogenic factor vascular endothelial growth factor (VEGF-A)...
  35. doi Inhibitor of apoptosis proteins gene expression and its correlation with prognostic factors in primary and metastatic uveal melanoma
    Michal Lederman
    Ophthalmology, Hadassah Hebrew University Medical Center, Hebrew University School of Medicine, Jerusalem, Israel
    Curr Eye Res 33:876-84. 2008
    ..We aimed to evaluate the expression of IAPs in uveal melanoma (UM) and its correlation with prognostic factors associated with death from metastatic UM...
  36. pmc Expression of vascular endothelial growth factor in uveal melanoma and its correlation with metastasis
    T G Sheidow
    Department of Ophthalmology, University of Western Ontario, London, Canada
    Br J Ophthalmol 84:750-6. 2000
    ..To evaluate the expression of vascular endothelial growth factor (VEGF) in uveal melanomas and correlate its presence with tumour characteristics and systemic metastasis...
  37. pmc Emerging insights into the molecular pathogenesis of uveal melanoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Future Oncol 4:629-36. 2008
    ..Taken together, this pathogenetic scheme can be used to construct a molecularly based and prognostically relevant classification of uveal melanomas that can be used clinically for personalized patient management...
  38. ncbi Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    Armelle Calipel
    INSERM U598 and IFR58, Institut Biomedical des Cordeliers, Paris 75006, France
    J Biol Chem 281:9238-50. 2006
    ..Altogether, our results suggest that the PKA/B-Raf pathway is a potential target for therapeutic strategies against (WT)B-Raf-expressing uveal melanoma...
  39. ncbi MMP-2 expression in uveal melanoma: differential activation status dictated by the cellular environment
    Melanie Berube
    Oncology and Molecular Endocrinology Research Center, Center Hospitalier Universitaire de Québec, Quebec, PQ, Canada
    Mol Vis 11:1101-11. 2005
    ..The purpose of this study was to compare the expression and activity of MMP-2 in uveal melanoma cell lines grown either in vitro on plastic culture plates or in vivo as tumors produced in chick embryos...
  40. ncbi Cytogenetics of uveal melanoma: a 7-year clinical experience
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:1925-31. 2007
    ..Since 1999, we have offered cytogenetic analysis to patients treated by local resection or enucleation. This study correlated our cytogenetic results with clinical and histologic predictors and disease-specific mortality...
  41. ncbi High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma
    Mohamed H Abdel-Rahman
    Department of Ophthalmology, The Ohio State University, Columbus, USA
    J Clin Oncol 24:288-95. 2006
    ..Our aim was to determine the frequency and clinical significance of PTEN alterations in uveal melanomas...
  42. ncbi Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
    ..To compare a gene expression-based classifier versus the standard genetic prognostic marker, monosomy 3, for predicting metastasis in uveal melanoma...
  43. ncbi Lack of BRAF mutations in uveal melanoma
    Donata Rimoldi
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland
    Cancer Res 63:5712-5. 2003
    ....
  44. ncbi Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival
    Paul R Van Ginkel
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Cancer Res 64:128-34. 2004
    ..These data show that the Axl pathway mediates increased survival of uveal melanoma cells, potentially advantageous during cancer dormancy, and that Axl may function in part through regulation of Cyr61...
  45. ncbi Combined immunologic and anti-angiogenic therapy reduces hepatic micrometastases in a murine ocular melanoma model
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Eye Res 31:557-62. 2006
    ..To evaluate the combined effect of neoadjuvant intracameral interferon alpha -2b and adjuvant low-dose angiostatin in reducing the number of hepatic micrometastases in a murine model of ocular melanoma...
  46. doi Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens
    Carol L Shields
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 118:396-401. 2011
    ..To determine the relationship between monosomy 3 and incidence of metastasis after genetic testing of uveal melanoma using fine-needle aspiration biopsy (FNAB)...
  47. pmc Does ocular treatment of uveal melanoma influence survival?
    B Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK
    Br J Cancer 103:285-90. 2010
    ..Randomised trials of treatment vs non-treatment of asymptomatic tumours are desirable but would be controversial, difficult, expensive and possibly inconclusive. Strategies for coping with uncertainty are needed to avoid unethical care...
  48. pmc Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma
    Evangelos S Gragoudas
    Clinical Research Unit, Retina Service, Massachusetts Eye and Ear Infirmary, Boston, USA
    Trans Am Ophthalmol Soc 100:43-8; discussion 48-9. 2002
    ..To quantitate long-term risk of local treatment failure after proton irradiation of choroidal/ciliary body melanomas and to evaluate risk of metastasis-related deaths after local failure...
  49. ncbi Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 64:7205-9. 2004
    ..These studies offer new insights into melanoma pathogenesis, and they provide a practical foundation for effective clinical predictive testing...
  50. ncbi Molecular classification of cutaneous malignant melanoma by gene expression profiling
    M Bittner
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 406:536-40. 2000
    ..Global transcript analysis can identify unrecognized subtypes of cutaneous melanoma and predict experimentally verifiable phenotypic characteristics that may be of importance to disease progression...
  51. ncbi Expression of angiogenic and immunosuppressive factors by uveal melanoma cell lines
    S A Ijland
    Department of Ophthalmology, Leiden University Medical Center, The Netherlands
    Melanoma Res 9:445-50. 1999
    ..The expression of VEGF and angiopoietin-2 in combination with a lack of angiopoietin-1 expression suggest high vascular remodelling capacity and could be of great relevance for the metastatic potential of uveal melanoma...
  52. ncbi Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma
    Young Sun
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 46:1561-4. 2005
    ..The current study was conducted to analyze the functional integrity of the p53 pathway in primary uveal melanoma cells...
  53. ncbi The prognostic value of cyclin D1, p53, and MDM2 protein expression in uveal melanoma
    S E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    J Pathol 191:120-6. 2000
    ..The expression of cyclin D1 in uveal melanoma is associated with a more aggressive course and histologically unfavourable disease. This could serve as a further independent prognostic factor in uveal melanoma...
  54. pmc Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance
    Grazia Ambrosini
    Laboratory of New Drug Development and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Clin Cancer Res 18:3552-61. 2012
    ....
  55. pmc Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Vis 14:1752-9. 2008
    ....
  56. doi Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma
    Sarah L Lake
    Pathology Department, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Invest Ophthalmol Vis Sci 51:4884-91. 2010
    ..To detect deletions and loss of heterozygosity of chromosome 3 in a rare subset of fatal, disomy 3 uveal melanoma (UM), undetectable by fluorescence in situ hybridization (FISH)...
  57. ncbi Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma
    N A Cross
    Academic Unit of Ophthalmology and Orthoptics, Division of Clinical Sciences South, University of Sheffield, UK
    Eye (Lond) 20:476-81. 2006
    ..Therefore, the purpose of this investigation was to determine the location of these partial deletions of chromosome 3 in uveal melanomas...
  58. pmc ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA Département d Ophtalmologie, Universite Laval, Quebec, QC, Canada Department of Otolaryngology, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 24:430-7. 2011
    ..These findings suggest that some uveal melanoma cells have greater potential for metastasis than others and that a better understanding of such cells may be necessary for more successful therapies for metastatic melanoma...
  59. pmc Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases
    Haochuan Li
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 50:5522-8. 2009
    ..To determine whether blocking the expression of the chemokine receptor CXCR4 using siRNA inhibits chemotactic responses of human uveal melanoma cells to liver-derived factors and prevents liver metastases...
  60. doi Translating uveal melanoma cytogenetics into clinical care
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, England
    Arch Ophthalmol 127:423-9. 2009
    ..To report our experience in translating uveal melanoma cytogenetics to routine clinical practice...
  61. pmc Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization
    Solange Landreville
    LOEX CUO Recherche, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du Saint Sacrement, and Département d ophtalmologie, Faculte de Medecine, Universite Laval, Quebec, Quebec, Canada
    Mol Vis 17:1324-33. 2011
    ..This study attempts to identify changes in the patterns of gene expression that lead to malignant transformation and proliferation of normal uveal melanocytes (UVM) using the Suppressive Subtractive Hybridization (SSH) technique...
  62. pmc Regulation of uveal melanoma interconverted phenotype by hepatocyte growth factor/scatter factor (HGF/SF)
    M J Hendrix
    Department of Anatomy and Cell Biology, Iowa Cancer Center, The University of Iowa College of Medicine, Iowa City 52242 1109, USA
    Am J Pathol 152:855-63. 1998
    ..Foci of metastatic melanoma to the liver stain diffusely for HGF/SF. Regulation of the uveal melanoma interconverted phenotype by HGF/SF may play an important role in the dissemination of this tumor...
  63. doi Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures
    K Valyi-Nagy
    Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Cancer Gene Ther 17:223-34. 2010
    ..These findings indicate that 3D tumor cell cultures can be used to identify distinct tumor cell populations with increased resistance to HSV-1 and to explore mechanisms of ECM-mediated tumor resistance to oncolytic virotherapy...
  64. ncbi Tumor sinuses- vascular channels
    J Timar
    National Institute of Oncology, Department of Tumor Progression Budapest, Rath Gy u 7 9, Budapest, H 1122, Hungary
    Pathol Oncol Res 6:83-6. 2000
    ..Literature data are available for the potential diagnostic and clinical significance of the tumor sinuses (vascular channels) stimulating further studies on this issue...
  65. pmc Frequency, molecular pathology and potential clinical significance of partial chromosome 3 aberrations in uveal melanoma
    Mohamed H Abdel-Rahman
    Department of Ophthalmology, Ohio State University, Columbus, OH, USA
    Mod Pathol 24:954-62. 2011
    ..Microsatellite-based genotyping of chromosome 3 is highly sensitive for detection of aggressive uveal melanoma...
  66. doi Mortality after uveal and conjunctival melanoma: which tumour is more deadly?
    Emma Kujala
    Department of Ophthalmology, Helsinki University Central Hospital, Finland
    Acta Ophthalmol 87:149-53. 2009
    ..We aimed to model and compare mortality rates for uveal melanoma (UM) and conjunctival melanoma (CM) by adjusting for differences in tumour size and local recurrence...
  67. doi Locoregional management of hepatic metastasis from primary uveal melanoma
    Takami Sato
    Department of Medical Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Semin Oncol 37:127-38. 2010
    ..This article reviews the efficacies, and morbidities of currently available locoregional therapies...
  68. pmc Role of tumor invasiveness, the extracellular matrix, and chromatin sequestration in the susceptibility of uveal melanoma to herpes simplex virus type 1
    Klara Valyi-Nagy
    Department of Pathology, University of Illinois at Chicago, College of Medicine, 840 South Wood Street, Room 110, M C 847, Chicago, IL 60612, USA
    Exp Eye Res 84:991-1000. 2007
    ..Furthermore, these findings indicate for the first time that HSV-1 infection is associated with global exposure of normally highly sequestered cellular DNA in malignant cells...
  69. pmc In-vivo xenograft murine human uveal melanoma model develops hepatic micrometastases
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA
    Melanoma Res 18:95-103. 2008
    ..These cells formed hepatic micrometastases in NU/NU mice after PC inoculation or tail vein injection, with significantly more micrometastases developing in the PC inoculation model than after tail vein injection...
  70. ncbi Expression of vascular endothelial growth factor a, matrix metalloproteinase 9 and extravascular matrix patterns in iris and ciliary body melanomas
    Afsun Sahin
    Department of Ophthalmology, Ocular Oncology Service, Hacettepe University School of Medicine, Ankara, Turkey
    Ophthalmic Res 39:40-4. 2007
    ....
  71. ncbi Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type
    Luminita Paraoan
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Exp Eye Res 83:911-9. 2006
    ....
  72. doi Variation of monosomy 3 status within uveal melanoma
    Lynn Schoenfield
    Department of Anatomic Pathology, and the Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 133:1219-22. 2009
    ..Monosomy 3, one such variable, can be determined using fluorescence in situ hybridization, either on enucleated samples, fine-needle aspiration biopsy, or tumor sample obtained by vitrector...
  73. ncbi Genomic investigations of posterior uveal melanoma
    Peter G Hovland
    Schepens Retina Associates, Boston, MA 02215, USA
    Semin Ophthalmol 20:231-8. 2005
    ..As an improved understanding of the cellular mechanisms used by uveal melanoma is gained, new opportunities to adapt or design therapeutic approaches may emerge...
  74. doi Single-cell tumor dormancy model of uveal melanoma
    Patrick T Logan
    The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, QC, Canada
    Clin Exp Metastasis 25:509-16. 2008
    ..It has been reported that difficulties in imaging single cells and the propensity for tumor cells to replicate rapidly in animal models account for the deficit of single-cell tumor dormancy models...
  75. ncbi Expression of vascular endothelial growth factor-A, matrix metalloproteinase-9, and extravascular matrix patterns and their correlations with clinicopathologic parameters in posterior uveal melanomas
    Afsun Sahin
    Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
    Jpn J Ophthalmol 51:325-31. 2007
    ....
  76. ncbi Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma
    Teresa M Walker
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Room K6 466 Clinical Sciences Center, Madison, WI 53792, USA
    Arch Ophthalmol 120:1719-25. 2002
    ..To study the expression of angiogenic factors Cyr61 and tissue factor (TF) in uveal melanoma and its correlation with blood vessel density...
  77. ncbi The heterogeneous distribution of monosomy 3 in uveal melanomas: implications for prognostication based on fine-needle aspiration biopsies
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Pathol Lab Med 131:91-6. 2007
    ..Fine-needle aspiration biopsy is being used to detect monosomy 3 in these tumors, based on the assumption that this chromosomal abnormality is distributed homogeneously throughout the tumor...
  78. ncbi Angiogenic profile of uveal melanoma
    Irene Christa Notting
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Curr Eye Res 31:775-85. 2006
    ..Our data suggest that the expression of (lymph) angiogenic factors may play a causal role in the angiogenesis and progression of uveal melanoma and distant metastasis...
  79. pmc DNA ploidy and S-phase fraction as prognostic factors in patients with uveal melanomas
    M Karlsson
    Department of Oncology, University Hospital, , Sweden
    Br J Cancer 71:177-81. 1995
    ..We further conclude that patients with small DNA diploid uveal melanomas of spindle cell type have a rather favourable prognosis...
  80. pmc Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival
    S L Smith
    Gene Function Group, Roy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 87:1308-13. 2002
    ..Our findings suggest a role for endothelin receptor type B in the metastasis of uveal melanoma and, potentially, in the metastasis of other neural crest tumours...
  81. ncbi p53 Immunoreactivity, Ki-67 expression, and microcirculation patterns in melanoma of the iris, ciliary body, and choroid
    Itay Chowers
    Department of Ophthalmology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Curr Eye Res 24:105-8. 2002
    ....
  82. pmc Evidence of macrophage and lymphocyte, but not dendritic cell, infiltration in posterior uveal melanomas, whilst cultured uveal melanomas demonstrate pluripotency by expressing CD68 and CD163
    Julia Woodward
    Academic Unit of Ophthalmology and Orthoptics, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Int J Exp Pathol 85:35-43. 2004
    ..Expression of the leucocyte antigen CD45 was observed in three tumours but was not present in any cultured cells, whilst the expression of the dendritic cell marker CD1a was absent from all samples...
  83. ncbi Molecular genetics of uveal melanoma
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University, School of Medicine, St Louis, MO 63110, USA
    Curr Eye Res 27:69-74. 2003
    ..Herein, we review the findings to date, discuss the insights they provide, and suggest future directions for molecular research in uveal melanoma...
  84. ncbi Uveal melanoma: epidemiologic aspects
    Arun D Singh
    Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ophthalmol Clin North Am 18:75-84, viii. 2005
    ....
  85. doi Integrative genomic analysis of aneuploidy in uveal melanoma
    Justis P Ehlers
    Wills Eye Hospital, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 14:115-22. 2008
    ..Uveal melanoma is an attractive solid tumor for studying aneuploidy because it is a relatively homogeneous cancer that is highly metastatic and has low nonspecific chromosomal instability...
  86. ncbi Risk of uveal melanoma
    Andrea Schmidt-Pokrzywniak
    Ophthalmology 114:1418; author reply 1418. 2007
  87. ncbi Identification of circulating malignant cells and its correlation with prognostic factors and treatment in uveal melanoma. A prospective longitudinal study
    S A Callejo
    Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, Quebec, Canada
    Eye (Lond) 21:752-9. 2007
    ..The purpose of the study was to detect circulating malignant cells (CMCs) in UMP and to correlate them with prognostic factors and therapy...
  88. ncbi Survival rates with uveal melanoma in the United States: 1973-1997
    Arun D Singh
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ophthalmology 110:962-5. 2003
    ..To determine variations in 5-year relative survival rates with primary uveal melanoma in the United States over a 25-year period from 1973 to 1997...
  89. ncbi Pathological and prognostic features of uveal melanomas
    Ian W McLean
    Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Can J Ophthalmol 39:343-50. 2004
    ..Other valuable prognostic factors are tumour-infiltrating lymphocytes and macrophages, and the presence of vascular loops...
  90. ncbi Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities
    Frank Tschentscher
    Institut fur Humangenetik, Universitatsklinikum Essen, 45122 Essen, Germany
    Cancer Res 63:2578-84. 2003
    ..Our findings suggest that there are two distinct entities of uveal melanoma that were previously unrecognized because they are not obviously distinguishable by clinicopathological features...
  91. doi Regional deletion and amplification on chromosome 6 in a uveal melanoma case without abnormalities on chromosomes 1p, 3 and 8
    Walter van Gils
    Departments of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Melanoma Res 18:10-5. 2008
    ..1-6q22 and the presence of one or more oncogenes on chromosomal region 6pter-6p21.2, which are likely to be important in UM and other tumors...
  92. ncbi Cooking and uveal melanoma risk: results from two German case-control studies
    Andreas Stang
    Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany
    Cancer Causes Control 14:377-80. 2003
    ..Two recent studies indicated that cooks may have an increased risk of uveal melanoma. Here we report findings of two German case-control studies regarding cooking and uveal melanoma risk...
  93. ncbi Noncontiguous tumor recurrence of posterior uveal melanoma after transscleral local resection
    Jonathan W Kim
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, England
    Arch Ophthalmol 120:1659-64. 2002
    ..To describe the clinical and histopathologic features of noncontiguous tumor recurrence after transscleral local resection of posterior uveal melanoma...
  94. ncbi Prognostic value of serum VEGF in melanoma patients: a pilot study
    Paolo Antonio Ascierto
    Division of Clinical Immunology, National Cancer Institute, Via M Semmola, 80131 Naples, Italy
    Anticancer Res 24:4255-8. 2004
    ..Vascular endothelial growth factor (VEGF) is involved in angiogenesis. We investigated the association of VEGF serum levels (pre-treatment and follow-up) with outcome in patients with melanoma...
  95. doi Positive interaction between light iris color and ultraviolet radiation in relation to the risk of uveal melanoma: a case-control study
    Andrea Schmidt-Pokrzywniak
    Clinical Epidemiology Unit, Institute of Medical Epidemiology, Biometry and Informatics, Medical Faculty, University of Halle Wittenberg, Halle, Germany
    Ophthalmology 116:340-8. 2009
    ..To examine the association among phenotypic characteristics, chronic and intermittent ultraviolet (UV) radiation, and the risk of uveal melanoma...
  96. ncbi Local excision of ciliary body tumors: a long-term prospective cohort study in China
    Wen bin Wei
    Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Chin Med J (Engl) 121:2152-6. 2008
    ..Therefore, we reported the outcome of locally excised ciliary body tumors after long-term follow-up...
  97. doi Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling
    Lori A Worley
    Department of Ophthalmology and Visual Sciences and Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Melanoma Res 18:184-90. 2008
    ..miRNA expression may represent a highly accurate biomarker for metastatic risk in uveal melanoma. In addition, these results may provide new insights into the role of miRNAs in tumor progression and the metastatic phenotype...
  98. ncbi Ultrasound biomicroscopic findings in a cavitary melanocytoma of the ciliary body
    Carmen Capeans
    Ocular Oncology Service, Department of Ophthalmology, Complejo Hospitalario Universitario de Santiago de Compostela, Spain
    Can J Ophthalmol 38:501-3. 2003
  99. ncbi Cell proliferation profile of five human uveal melanoma cell lines of different metastatic potential
    Jean Claude Marshall
    The Henry C Witelson Ocular Pathology Laboratory and Registry, McGill University, Montreal, Canada
    Pathobiology 71:241-5. 2004
    ..The aim of this study was to establish a proliferation profile of uveal melanoma cell lines, using different methods, and to compare it with their previously determined metastatic potential (MP)...
  100. ncbi Intraocular melanocytoma in association with bone formation
    Paul Hiscott
    Arch Ophthalmol 121:1791-4. 2003
  101. ncbi International uveal melanoma incidence trends in view of a decreasing proportion of morphological verification
    Andreas Stang
    Institute of Medical Epidemiology, Biometry and Informatics, University Clinics of Halle, Saale, Germany
    Int J Cancer 114:114-23. 2005
    ..Uveal melanoma incidence rates remained quite stable during the period 1983-97. The interpretation of uveal melanoma incidence trends is complicated by missing data on topography within the eye, morphology and basis of diagnosis...

Research Grants107 found, 100 shown here

  1. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  2. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre Triozzi; Fiscal Year: 2007
    ....
  3. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre Triozzi; Fiscal Year: 2009
    ....
  4. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
    ....
  5. Uveal Melanoma Micrometastasis
    Pierre L Triozzi; Fiscal Year: 2010
    ..Micrometastases, microscopic deposits of tumor that have spread via the bloodstream, are present in many patients with uveal melanoma at diagnosis. This project will test new methods of identifying and inhibiting these deposits. ..
  6. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2004
    ..abstract_text> ..
  7. MICROCIRCULATION OF UVEAL MELANOMA
    Robert Folberg; Fiscal Year: 2002
    ..The investigators expect to show that ultrasonographic criteria based on power image spectrum parameters can provide a noninvasive substitute for biopsy. ..
  8. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2009
    ....
  9. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  10. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2007
    ....
  11. Molecular Predictive Testing in Ocular Melanoma
    JAMES W HARBOUR; Fiscal Year: 2010
    ..This research proposal represents an application of this strategy and provides a proof of principle for similar approaches in other cancers. ..
  12. MICROCIRCULATION OF UVEAL MELANOMA
    Robert Folberg; Fiscal Year: 2007
    ..abstract_text> ..
  13. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2007
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  14. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2007
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  15. IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2010
    ..These studies will lead to improved strategies for re-establishing immune privilege of corneal transplants and offsetting the untoward effects of allergic diseases on the fate of corneal transplants. ..
  16. TRH Production and Regulation by Human Melanoma
    Julie Ellerhorst; Fiscal Year: 2006
    ..In Specific Aim #2, cell lines will be used for in vitro studies to determine if one or more of the mechanisms of hypothalamic TRH regulation are relevant to the control of TRH production by melanoma cells. ..
  17. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2007
    ....
  18. IMMUNOLOGICAL MODULATION OF OCULAR TUMOR METASTASES
    Jerry Niederkorn; Fiscal Year: 2006
    ..The long rang goal of this project is to design, develop, and evaluate novel immunotherapeutic modalities for the prevention and treatment of uveal melanoma metastases. ..
  19. Thyroid Stimulating Hormone Promotes the Growth and Progression of Human Melanoma
    Julie Ellerhorst; Fiscal Year: 2007
    ..Medications used to treat hypothyroidism may actually be therapeutic for melanoma. Furthermore, melanoma cases may be prevented by heightened surveillance of individuals with a history of hypothyroidism. ..
  20. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2006
    ..g., corneal transplantation). In some cases, it may be desirable to abrogate immune privilege to promote the immune-rejection of sight- and life-threatening ocular neoplasms. ..
  21. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2002
    ..g., corneal transplantation) or abrogate immune privilege to protect against sight- and life-threatening neoplasms. ..
  22. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 1992
    ..Understanding immune privilege may lead to strategies for promoting long term survival of therapeutic organ grafts...
  23. IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2001
    ..Both strategies procure antigen-specific suppression of host immune responses and should prove useful in preventing corneal graft rejection. ..
  24. FACTORS INVOLVED IN MALIGNANT BEHAVIOR OF HUMAN TUMORS
    Liliana Ossowski; Fiscal Year: 2007
    ....
  25. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2009
    ....
  26. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  27. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2003
    ..g., corneal transplantation). In some cases, it may be desirable to abrogate immune privilege to promote the immune-rejection of sight- and life-threatening ocular neoplasms. ..
  28. IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2006
    ..All three of these aims will be addressed in a well-characterized mouse model of penetrating keratoplasty. ..
  29. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 1993
    ..The long range goals of this project are to understand immune regulatory processes in the eye and to manipulate such processes to reduce immune-mediated injury and corneal graft rejection...
  30. OCULAR MELANOMA
    Dennis Robertson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed; and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  31. PERICYTES IN ANGIOGENESIS IN NEUROFIBROMATOSIS TYPE 1
    Ugur Ozerdem; Fiscal Year: 2003
    ..3) The investigators will examine the effect of the NF1-/- and NF1-/+ genotypes on microvascularization in embryonic development. The ability of NG2 ablation to rescue micro and macrovascular defects will be determined. ..
  32. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ....