keratitis

Summary

Summary: Inflammation of the cornea.

Top Publications

  1. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
  2. pmc Severe infective keratitis leading to hospital admission in New Zealand
    T Wong
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Br J Ophthalmol 87:1103-8. 2003
  3. pmc Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review
    Loretta B Szczotka-Flynn
    Departmentsof Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Eye Contact Lens 36:116-29. 2010
  4. pmc ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 188:1884-95. 2012
  5. ncbi Microbial keratitis: aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia
    T J Norina
    Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
    Singapore Med J 49:67-71. 2008
  6. pmc TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 185:4272-83. 2010
  7. pmc Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade
    Usha Gopinathan
    Jhaveri Microbiology Centre, Prof Brien Holden Eye Research Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Prasad Marg, Banjara Hills, Hyderabad, India
    Indian J Ophthalmol 57:273-9. 2009
  8. pmc Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
    T Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Br J Ophthalmol 87:834-8. 2003
  9. ncbi Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
  10. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010

Research Grants

  1. Mechanisms of Epithelial Alterations in Diabetic Cornea
    Alexander Ljubimov; Fiscal Year: 2009
  2. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
  3. OCULAR DISPOSITION OF ACYCLOGUANOSINE ANALOGUES
    Ashim Mitra; Fiscal Year: 2005
  4. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2010
  5. Ocular Disposition of Antimicrobial Agents
    Ashim Mitra; Fiscal Year: 2009
  6. Ocular Disposition of Antimicrobial Agents
    Ashim Mitra; Fiscal Year: 2007
  7. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
  8. Herpes simplex virus egress from cells and spread in neuronal axons
    David C Johnson; Fiscal Year: 2010
  9. Herpes simplex virus egress from cells and spread in neuronal axons
    David C Johnson; Fiscal Year: 2010
  10. Staph keratitis: mechanism and arrest of ocular damage
    RICHARD JOSEPH O apos CALLAGHAN; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
    ..that colonize lenses can lead to infection and inflammation, but the most common cause of infection (microbial keratitis; MK) remains the Gram-negative bacterium Pseudomonas aeruginosa. P...
  2. pmc Severe infective keratitis leading to hospital admission in New Zealand
    T Wong
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Br J Ophthalmol 87:1103-8. 2003
    To identify key risk factors and the management and outcome of severe infective keratitis leading to public hospital admission in New Zealand.
  3. pmc Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review
    Loretta B Szczotka-Flynn
    Departmentsof Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Eye Contact Lens 36:116-29. 2010
    ..In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection...
  4. pmc ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 188:1884-95. 2012
    ..To determine the role of type III secretion in the pathogenesis of P. aeruginosa keratitis, corneas of C57BL/6 mice were infected with P...
  5. ncbi Microbial keratitis: aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia
    T J Norina
    Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
    Singapore Med J 49:67-71. 2008
    ..Our objective is to determine the epidemiological characteristics, clinical features, risk factors and the aetiology of microbial keratitis in patients admitted to Hospital Universiti Sains Malaysia (HUSM).
  6. pmc TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 185:4272-83. 2010
    ..Using a murine model of keratitis in which abraded corneas are infected with P...
  7. pmc Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade
    Usha Gopinathan
    Jhaveri Microbiology Centre, Prof Brien Holden Eye Research Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Prasad Marg, Banjara Hills, Hyderabad, India
    Indian J Ophthalmol 57:273-9. 2009
    To review the epidemiological characteristics, microbiological profile, and treatment outcome of patients with suspected microbial keratitis.
  8. pmc Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
    T Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Br J Ophthalmol 87:834-8. 2003
    To identify predisposing factors and to define clinical and microbiological characteristics of bacterial keratitis in current practice.
  9. ncbi Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
    Pseudomonas aeruginosa (P. aeruginosa) is a common organism associated with bacterial keratitis, especially in those who use extended wear contact lenses...
  10. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ..To enhance our understanding of the pathogenesis of Aspergillus keratitis, we developed a murine model in which red fluorescent protein (RFP)-expressing A. fumigatus (Af293...
  11. pmc Effect of femtosecond laser energy level on corneal stromal cell death and inflammation
    Fabricio Witzel de Medeiros
    Cleveland Clinic, Cole Eye Institute, Ohio 44195, USA
    J Refract Surg 25:869-74. 2009
    ..To analyze the effects of variations in femtosecond laser energy level on corneal stromal cell death and inflammatory cell influx following flap creation in a rabbit model...
  12. ncbi Corneal endotheliitis associated with evidence of cytomegalovirus infection
    Soon Phaik Chee
    Singapore National Eye Centre, Singapore
    Ophthalmology 114:798-803. 2007
    ..To describe the clinical presentation of cytomegalovirus (CMV) corneal endotheliitis in human immunodeficiency virus (HIV)-negative patients...
  13. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002
    To evaluate the outcome of corneal grafting in patients with stromal keratitis of herpetic (HSK) and non-herpetic origin, using predefined diagnostic criteria and standardised postoperative therapeutic strategies.
  14. ncbi Analysis of the risk factors predisposing to fungal, bacterial & Acanthamoeba keratitis in south India
    M Jayahar Bharathi
    Microbiology Research Centre, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli 627 001, Tamil Nadu, India
    Indian J Med Res 130:749-57. 2009
    Infective keratitis is rare in the absence of predisposing factors. The pattern of risk factors predisposing to infective keratitis varies with geographical regions and also influences the type of infection that occurs...
  15. ncbi Candida parapsilosis keratitis
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Cornea 22:51-5. 2003
    To present clinical, microbiologic, and histopathologic features of keratitis due to Candida parapsilosis.
  16. ncbi Late bacterial keratitis after implantation of intrastromal corneal ring segments
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    J Cataract Refract Surg 29:407-9. 2003
    We report a case of bacterial keratitis that occurred after implantation of intrastromal corneal ring segments (Intacs)...
  17. pmc Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium
    Rajapandian Sivaganesa Karthikeyan
    Dr G Venkatasamy Eye Research Institute, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    J Infect Dis 204:942-50. 2011
    ..Filamentous fungi of the genera Aspergillus and Fusarium are major causes of corneal ulcers in the United States and in the developing world and result in significant visual impairment and blindness...
  18. doi Corneal cross-linking as supplementary treatment option in melting keratitis: a case series
    L Muller
    Department of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland
    Klin Monbl Augenheilkd 229:411-5. 2012
    ..Recently, corneal cross-linking (CXL) has emerged as an additional treatment option. The present study evaluates whether CXL induces a clinical improvement in melting keratitis not responding to conventional treatment.
  19. doi Microbial keratitis after LASIK
    Prashant Garg
    Cornea and Anterior Segment Service and Jhaveri Microbiology Center, L V Prasad Eyes Institute, Hyperabad, India
    J Refract Surg 26:209-16. 2010
    To report cases of microbial keratitis after LASIK from a tropical climatic zone.
  20. ncbi Neurotrophic keratitis
    S Bonini
    Laboratory of Ophthalmology, Interdisciplinary Center for Biomedical Research, University of Rome, Rome, Italy
    Eye (Lond) 17:989-95. 2003
    ..Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented...
  21. pmc Femtosecond laser and microkeratome corneal flaps: comparison of stromal wound healing and inflammation
    Marcelo V Netto
    The Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 23:667-76. 2007
    ..To examine early postoperative wound healing in rabbit corneas that had LASIK flaps formed with three different models (15 KHz, 30 KhZ, and 60 KHz) of a femtosecond laser compared with flaps formed with a microkeratome...
  22. pmc Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis
    Ashish V Chintakuntlawar
    University of Oklahoma Health Sciences Center, Department of Ophthalmology, Oklahoma City, Oklahoma, United States of America
    PLoS Pathog 6:e1000841. 2010
    ..Using a unique mouse model of adenovirus keratitis, we studied the role of various virus-associated molecular patterns in subsequent innate immune responses of ..
  23. pmc Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome
    Helmuth A Sánchez
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gen Physiol 136:47-62. 2010
    ..two such mutations, A40V and G45E, which are positioned near the TM1/E1 boundary and are associated with keratitis ichthyosis deafness (KID) syndrome...
  24. pmc Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury
    Joo Youn Oh
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, TX 76502, USA
    Proc Natl Acad Sci U S A 107:16875-80. 2010
    ..The data indicated that TSG-6, a therapeutic protein produced by MSCs in response to injury signals, can protect the corneal surface from the excessive inflammatory response following injury...
  25. pmc Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections
    Rosalind M K Stewart
    Institute of Infection and Global Health, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    J Clin Microbiol 49:993-1003. 2011
    ..aeruginosa isolates from patients with corneal ulcers (keratitis). We then used population analysis to compare the keratitis isolates to a wider collection of P...
  26. pmc Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease
    J H Chang
    School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Br J Ophthalmol 90:103-8. 2006
    ..agents have an important role in the pathogenesis of various inflammatory eye diseases, such as uveitis and keratitis. Microbial infections of the eye such as microbial keratitis, ocular onchocerciasis, bacterial endophthalmitis, ..
  27. pmc Phototoxicity and the cornea
    O D Schein
    Massachusetts Eye and Ear Infirmary, Boston
    J Natl Med Assoc 84:579-83. 1992
    ..Ultraviolet keratitis is associated with relatively short exposures to light sources such as welding arcs or tanning lamps...
  28. ncbi A femtosecond laser creates a stronger flap than a mechanical microkeratome
    Jae Yong Kim
    Department of Ophthalmology and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Invest Ophthalmol Vis Sci 47:599-604. 2006
    ..To compare corneal flaps made with a femtosecond (FS) laser with those made with a mechanical microkeratome (MM) in rabbits, measuring early postoperative inflammation and apoptosis and late postoperative adhesion strength...
  29. pmc Phylogenetic diversity and microsphere array-based genotyping of human pathogenic Fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006
    Kerry O'Donnell
    Microbial Genomics and Bioprocessing Research Unit, Agricultural Research Service, U S Department of Agriculture, 1815 North University Street, Peoria, IL 61604 3999, USA
    J Clin Microbiol 45:2235-48. 2007
    In 2005 and 2006, outbreaks of Fusarium keratitis associated with soft contact lens use occurred in multiple U.S. states and Puerto Rico...
  30. pmc Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis
    A K Leck
    Department of Infectious and Tropical Diseases, Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 86:1211-5. 2002
    A multicentre study was carried out in Ghana and southern India to determine the aetiology of suppurative keratitis in two regions located at similar tropical latitudes. Studies of fungal keratitis from the literature were reviewed.
  31. ncbi Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study
    Leonardo Mastropasqua
    Department of Medicine and Aging Science, Ophthalmic Clinic, University of Chieti Pescara, Chieti, Italy
    Am J Ophthalmol 142:736-44. 2006
    ..To evaluate dendritic cell (DCs) density, distribution, and morphology in central corneal and limbal epithelium in normal subjects and patients with immune-mediated corneal inflammation using in vivo confocal microscopy (IVCM)...
  32. ncbi Contact lens-associated microbial keratitis
    Aline Silveira Moriyama
    Department of Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Bras Oftalmol 71:32-6. 2008
    Contact lens-associated microbial keratitis is a severe condition with sight-threatening potential and increasing incidence. Information regarding the etiological agents is essential in guiding management and may vary geographically...
  33. doi Optimizing diagnosis and management of nocardia keratitis, scleritis, and endophthalmitis: 11-year microbial and clinical overview
    Francis Char Decroos
    Duke University Eye Center, Durham, North Carolina, USA
    Ophthalmology 118:1193-200. 2011
    To identify clinical factors and microbiological assays that facilitate a rapid diagnosis of Nocardia keratitis, scleritis, and endophthalmitis, and to determine optimal medical and surgical management strategies.
  34. ncbi Ultrastructural analysis of slime positive & slime negative Staphylococcus epidermidis isolates in infectious keratitis
    N Nayak
    Department of Ocular Microbiology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 125:767-71. 2007
    ....
  35. ncbi Early diagnosis of amoebic keratitis due to a mixed infection with Acanthamoeba and Hartmannella
    Jacob Lorenzo-Morales
    University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda Astrofísico Fco Sánchez, S N, 38203, La Laguna, Tenerife, Canary Islands, Spain
    Parasitol Res 102:167-9. 2007
    A mixed keratitis due to Acanthamoeba and Hartmannella species is reported. The patient was a soft contact lens wearer. Early diagnosis was achieved by polymerase chain reaction and culture...
  36. pmc Moxifloxacin and cholesterol combined treatment of pneumococcal keratitis
    Melissa E Sanders
    Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Curr Eye Res 35:1142-7. 2010
    Compare the efficacy of treatment of pneumococcal keratitis with cholesterol, moxifloxacin, or a mixture of the two (moxifloxacin/cholesterol).
  37. ncbi Role of innate and adaptive immunity in the pathogenesis of keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:133-8. 2005
    Pseudomonas aeruginosa is a common organism associated with bacterial keratitis primarily resulting from contact lens usage...
  38. doi Fungal keratitis: changing pathogens and risk factors
    Ula Jurkunas
    Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Cornea 28:638-43. 2009
    To describe changes in demographics and pathogens for fungal keratitis cases diagnosed at the Massachusetts Eye and Ear Infirmary.
  39. pmc Topical flagellin protects the injured corneas from Pseudomonas aeruginosa infection
    Ashok Kumar
    Departments of Ophthalmology and Anatomy and Cell Biology, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St Antoine, Detroit, MI 48201, USA
    Microbes Infect 12:978-89. 2010
    ..aeruginosa. Using a mouse model of Pseudomonas keratitis, we evaluated the protective effects of topical application of flagellin, a ligand for Toll-Like receptor 5 (..
  40. ncbi Keratitis
    S Sharma
    Jhaveri Microbiology Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, AP, India
    Biosci Rep 21:419-44. 2001
    Corneal inflammation or keratitis is a significant cause of ocular morbidity around the world...
  41. ncbi Clinical characteristics of microbial keratitis in a university hospital in Taiwan
    Chien Fan Fong
    Department of Ophthalmology, Hsin Chu Hospital, Hsin Chu, Taiwan
    Am J Ophthalmol 137:329-36. 2004
    To analyze the clinical and microbiological characteristics of microbial keratitis at the National Taiwan University Hospital in the preceding 10 years.
  42. doi Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins
    Mark D P Willcox
    School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
    Clin Exp Optom 94:161-8. 2011
    Microbial keratitis is a rare disease but most commonly caused by bacterial infection. Two of the most common bacteria to cause microbial keratitis are Pseudomonas aeruginosa and Staphylococcus aureus...
  43. ncbi Characteristics of and risk factors for contact lens-related microbial keratitis in a tertiary referral hospital
    K Edwards
    School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia
    Eye (Lond) 23:153-60. 2009
    A retrospective case-control study was conducted at a tertiary referral hospital to determine the characteristics of and risk factors for contact lens (CL) related presumed microbial keratitis.
  44. ncbi Microbial keratitis in the elderly: a 32-year review
    Renato Magalhães Passos
    Ophthalmology Department, Escola Paulista de Medicina, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Arq Bras Oftalmol 73:315-9. 2010
    To describe the demographic characteristics, associated factors and causative agents of infectious keratitis in the elderly in a tertiary referral center in São Paulo, Brazil.
  45. pmc Geographic variations in microbial keratitis: an analysis of the peer-reviewed literature
    Ameet Shah
    Moorfields Eye Hospital, London, UK
    Br J Ophthalmol 95:762-7. 2011
    The epidemiology of microbial keratitis has been investigated in several studies by analysis of organisms cultured from corneal scrapes...
  46. ncbi Phototherapeutic keratectomy in treating keratomycosis
    Chang Ping Lin
    Department of Ophthalmology, Changhua Christian Hospital, Taiwan
    Cornea 24:262-8. 2005
    ..To evaluate the efficacy of using phototherapeutic keratectomy (PTK) in the treatment of superficial keratomycosis...
  47. ncbi Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmannella infection
    D Aitken
    Department of Ophthalmology, University of Glasgow, Scotland
    Ophthalmology 103:485-94. 1996
    To support the hypothesis that Acanthamoeba is not a unique cause of amebic keratitis, we report a case of amebic keratitis in which viable Acanthamoeba could not be isolated from corneal tissue...
  48. ncbi Candida parapsilosis keratitis following treatment of epithelial ingrowth after laser in situ keratomileusis
    Renee Solomon
    Ophthalmic Consultants of Long Island, Rockville Centre, NY 11570, USA
    Eye Contact Lens 30:85-6. 2004
    ..To present a case of Candida parapsilosis following laser in situ keratomileusis (LASIK)...
  49. ncbi Epidemiology and medical prediction of microbial keratitis in southeast Brazil
    Marlon Moraes Ibrahim
    Department of Ophthalmology, Ribeirao Preto Medical School, Sao Paulo University, Avenida Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    Arq Bras Oftalmol 74:7-12. 2011
    The goals of the study were the following: 1) to show the epidemiology of microbial keratitis (MK) in the southeast Brazil, 2) to compare the epidemiological differences between fungal (FK) and bacterial keratitis (BK), and 3) to ..
  50. doi Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing
    Nobuyuki Ebihara
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:8549-57. 2011
    ..To investigate the role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing...
  51. ncbi Immunity to lysostaphin and its therapeutic value for ocular MRSA infections in the rabbit
    Joseph J Dajcs
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center in New Orleans, New Orleans 70112, USA
    Invest Ophthalmol Vis Sci 43:3712-6. 2002
    ..To determine the effects of immunization against lysostaphin on the bactericidal action of lysostaphin in ocular tissue and the possible induction of allergic reactions...
  52. ncbi Delayed-onset multifocal polymicrobial keratitis after laser in situ keratomileusis
    David Ritterband
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    J Cataract Refract Surg 28:898-9. 2002
    We report a case of mixed Aspergillus fumigatus and coagulase-negative Staphylococcus stromal keratitis in a 43-year-old man who developed discomfort and swelling in his right eye 20 days after uneventful bilateral laser in situ ..
  53. pmc Initial therapy for suppurative microbial keratitis in Iraq
    Faiz Al-Shakarchi
    Ibn Al Haetham Teaching Eye Hospital, BGW, Baghdad, Iraq
    Br J Ophthalmol 91:1583-7. 2007
    To provide data-based guidelines for selection of an appropriate initial therapy for management suppurative microbial keratitis (SMK) in Iraq.
  54. ncbi Study of the first contact management profile of cases of infectious keratitis: a hospital-based study
    R B Vajpayee
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Cornea 19:52-6. 2000
    To study the management pattern and examine the role of cultures and antibiotic sensitivity testing in infectious keratitis.
  55. doi Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis
    Man H Choy
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    J Med Microbiol 57:1539-46. 2008
    ..is one of the common pathogens associated with corneal infection, particularly in contact lens-related keratitis events. The pathogenesis of P...
  56. ncbi Beta-defensin-2 promotes resistance against infection with P. aeruginosa
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 182:1609-16. 2009
    ..Collectively, the data provide evidence that mBD2, but not mBD1, is required for host resistance against P. aeruginosa-induced corneal infection...
  57. doi Medical treatment for combined Fusarium and Acanthamoeba keratitis
    Hsin Chiung Lin
    Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan
    Acta Ophthalmol 87:199-203. 2009
    Acanthamoeba and fungal keratitis are rare ocular infections. We report cases of combined Fusarium and Acanthamoeba keratitis and the clinical course of medical treatment.
  58. ncbi Topical cyclosporin A in the management of therapeutic keratoplasty for mycotic keratitis
    Henry D Perry
    Department of Ophthalmology, North Shore University Hospital, Long Island Jewish Medical Center, Great Neck, New York, U S A
    Cornea 21:161-3. 2002
    To investigate the efficacy of topical cyclosporine A 0.5% as a substitute for corticosteroids in the management of therapeutic keratoplasties for mycotic keratitis.
  59. ncbi Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and North America
    D S C Lam
    Department of Ophthalmology and Visual Sciences, Prince of Wales and Hong Kong Eye Hospitals, The Chinese University of Hong Kong, People s Republic of China
    Eye (Lond) 16:608-18. 2002
    To establish the incidence, etiology and risk factors for microbial keratitis (MK) in Hong Kong.
  60. ncbi Two cases of pneumococcal keratitis following myopic LASIK
    Tova Lifshitz
    Department of Ophthalmology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Refract Surg 21:498-501. 2005
    To report two cases of pneumococcal keratitis after LASIK.
  61. ncbi Keratitis after implantation of intrastromal corneal ring segments
    Raneen Shehadeh-Masha'our
    Department of Ophthalmology, Bnai Zion Medical Center Rappaport Faculty of Medicine Technion, Golomb Street 47, Haifa, Israel
    J Cataract Refract Surg 30:1802-4. 2004
    ..This progressed to a lower channel infection followed by diffuse keratitis. Culture from the conjunctiva was positive for Staphylococcus epidermidis, but cultures from the cornea were ..
  62. ncbi Keratomycosis in and around Chandigarh: a five-year study from a north Indian tertiary care hospital
    Jagdish Chander
    Department of Microbiology, Government Medical College Hospital, Sector 32, Chandigarh, India
    Indian J Pathol Microbiol 51:304-6. 2008
    ..88%). Thus, hyaline filamentous fungi were the most common etiological agents and mechanical trauma with vegetative matter was the most common predisposing factor. Males in age group of 21-50 years were more commonly affected...
  63. pmc Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis
    Joseph J Dajcs
    Department of Microbiology, Immunology, and Parasitology, LSU Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Antimicrob Agents Chemother 48:1948-52. 2004
    The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic ..
  64. doi The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection
    X Jin
    Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People s Republic of China
    Eur J Clin Microbiol Infect Dis 29:231-8. 2010
    b>Keratitis caused by Pseudomonas aeruginosa is a potentially vision-threatening condition that requires prompt treatment to prevent vision loss...
  65. doi Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Exp Eye Res 86:929-35. 2008
    ..In conclusion, UV-damaged cornea is recoverable without MIF, however it takes longer time than normal condition. Cornea is less damaged and can make a quick recovery when ocular tissue is enough supplied with MIF...
  66. ncbi A Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice
    Emma B H Hume
    The School of Optometry and Vision Science, The University of New South Wales, Australia
    Immunol Cell Biol 83:294-300. 2005
    Staphylococcus is a leading cause of the potentially blinding disease microbial keratitis. Even with the use of antibiotic therapy, the host inflammatory response continues to damage the cornea, which may lead to blindness...
  67. ncbi Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits
    Yusuf Onlen
    Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Mustafa Kemal University, Antakya Hatay, Turkey
    Microbiol Res 162:62-8. 2007
    ..out whether propolis could be an alternative or an adjunctive treatment, in experimental Pseudomonas aeruginosa keratitis. Intrastromal P. aeruginosa strains were given to both eyes of 20 young New Zealand white rabbits...
  68. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  69. ncbi A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad
    Jay R Montgomery
    USN, National Naval Medical Center, Bethesda, Maryland 20889, USA
    J Am Acad Dermatol 51:377-82. 2004
    ..deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome...
  70. pmc Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection
    R J O'Callaghan
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112, USA
    Infect Immun 65:1571-8. 1997
    ..These studies confirm the role of alpha-toxin as a major virulence factor during S. aureus keratitis and implicate beta-toxin, a mediator of edema, as a lesser contributor to ocular damage.
  71. doi Riboflavin and ultraviolet a collagen crosslinking of the cornea for the treatment of keratitis
    Håkan Morén
    Department of Ophthalmology, Regional Hospital of Västerås, Vasteras, Sweden
    Cornea 29:102-4. 2010
    To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis.
  72. pmc Keratitis due to Aspergillus flavus: clinical profile, molecular identification of fungal strains and detection of aflatoxin production
    George Leema
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tamil Nadu, India
    Mol Vis 16:843-54. 2010
    To document the clinical profile of patients with keratitis due to Aspergillus flavus and to elaborate on differences in the aflatoxin-producing potential of keratitis strains versus environmental strains of A. flavus.
  73. doi Outbreak of Nocardia keratitis after photorefractive keratectomy: clinical, microbiological, histopathological, and confocal scan study
    Mohammad Ali Javadi
    Labbafinejad Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran
    J Cataract Refract Surg 35:393-8. 2009
    Nocardia keratitis occurred in 4 eyes of 3 patients (2 women and 1 man) who had photorefractive keratectomy (PRK) by the same surgeon at the same center...
  74. ncbi Stenotrophomonas maltophilia keratitis and scleritis
    Yeong Fong Chen
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Chang Gung Med J 28:142-50. 2005
    ..The report describes six cases of Stenotrophomonas maltophilia (S. maltophilia) keratitis and scleritis. To our knowledge, this is the foremost report of S. maltophilia scleritis.
  75. ncbi Pigmented plaque presentation of dematiaceous fungal keratitis: a clinicopathologic correlation
    Prashant Garg
    Cornea Service, LV Prasad Eye Institute, Hyderabad, India
    Cornea 23:571-6. 2004
    To evaluate the clinical, microbiologic, and histopathologic features of dematiaceous fungal keratitis cases presenting with pigmented, raised, plaque-like infiltrate.
  76. doi Bioadhesive sulfacetamide sodium microspheres: evaluation of their effectiveness in the treatment of bacterial keratitis caused by Staphylococcus aureus and Pseudomonas aeruginosa in a rabbit model
    Demet Sensoy
    Department of Pharmaceutical Technology, Istanbul University, Istanbul, Turkey
    Eur J Pharm Biopharm 72:487-95. 2009
    ..to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture of polymers such as pectin, polycarbophil and ..
  77. ncbi Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 46:4209-16. 2005
    To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis.
  78. ncbi Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model
    Mike P Holzer
    Magill Research Center for Vision Correction, Storm Eye Institute, Medical University of South Carolina, Charleston 29425, USA
    J Cataract Refract Surg 29:795-802. 2003
    ..To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery...
  79. doi Benzalkonium chloride enhances the antibacterial efficacy of gatifloxacin in an experimental rabbit model of intrastromal keratitis
    Eric G Romanowski
    The Charles T Campbell Ophthalmic Microbiology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Ocul Pharmacol Ther 24:380-4. 2008
    ..The aim of this study was to determine whether a preservative (0.005% benzalkonium chloride [BAK]) enhances the antibacterial efficacy of an antibiotic (0.3% gatifloxacin, [GAT]) in vivo...
  80. pmc Human tear fluid protects against Pseudomonas aeruginosa keratitis in a murine experimental model
    Mary S F Kwong
    School of Optometry, University of California, Berkeley, CA 94720 2020, USA
    Infect Immun 75:2325-32. 2007
    Pseudomonas aeruginosa keratitis is an acute sight-threatening infection...
  81. ncbi Corneal flap complications in refractive surgery: Part 2: postoperative treatments of diffuse lamellar keratitis in an experimental animal model
    Mike P Holzer
    Magill Research Center for Vision Correction, Storm Eye Institute, Medical University of South Carolina, Charleston 29425, USA
    J Cataract Refract Surg 29:803-7. 2003
    To induce diffuse lamellar keratitis (DLK) and investigate a prophylactic treatment with pharmacological agents.
  82. doi Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes
    Jack R Lee
    Department of Physiology and Biophysics, Stony Brook University Medical Center, Stony Brook, New York 11794 8661, USA
    J Invest Dermatol 129:870-8. 2009
    ..This set of data confirms that aberrant hemichannel activity is a common feature of Cx26 mutations associated with KID syndrome, and this may contribute to a loss of cell viability and tissue integrity...
  83. pmc Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome
    Gabriele Richard
    Department of Dermatology and Cutaneous Biology and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hum Genet 70:1341-8. 2002
    b>Keratitis-ichthyosis-deafness syndrome (KID) is a rare ectodermal dysplasia characterized by vascularizing keratitis, profound sensorineural hearing loss (SNHL), and progressive erythrokeratoderma, a clinical triad that indicates a ..
  84. ncbi Microbial keratitis in West Anatolia, Turkey: a retrospective review
    Safiye Yilmaz
    Department of Ophthalmology, Izmir Ataturk Training and Research Hospital, Mustafa Kemal Cad No 36 4, 35040 Bornova, Izmir, Turkey
    Int Ophthalmol 27:261-8. 2007
    To analyze the clinical and microbiological characteristics of microbial keratitis in West Anatolia, Turkey during a 16-year period.
  85. pmc Genetically regulated filamentation contributes to Candida albicans virulence during corneal infection
    Beth E Jackson
    Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Microb Pathog 42:88-93. 2007
    ..This study evaluated the role of fungal hyphal extension in experimental C. albicans keratitis using genetically altered yeast strains...
  86. ncbi Role of bacterial proteases in pseudomonal and serratial keratitis
    Koki Matsumoto
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Biol Chem 385:1007-16. 2004
    Pseudomonas aeruginosa and Serratia marcescens can cause refractory keratitis resulting in corneal perforation and blindness. These bacteria produce various kinds of proteases...
  87. ncbi Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study
    M Jayahar Bharathi
    Department of Microbiology, Aravind Eye Care System, Tirunelveli, Tamil Nadu, India
    Indian J Ophthalmol 51:315-21. 2003
    To study the epidemiological characteristics and laboratory diagnosis of fungal keratitis seen at a tertiary eye care referral centre in South India.
  88. ncbi Epidemiological and microbiological diagnosis of suppurative keratitis in Gangetic West Bengal, eastern India
    Samar K Basak
    Disha Eye Hospital and Research Centre, Barrackpore, North 24 Parganas, West Bengal 700 120, India
    Indian J Ophthalmol 53:17-22. 2005
    ..To determine the epidemiological pattern and risk factors involved in suppurative corneal ulceration in Gangetic West Bengal, eastern India, and to identify the specific microbial agents responsible for corneal infections...
  89. ncbi Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness
    Dwan A Gerido
    Dept of Physiology and Biophysics, State University of New York, T5 147, Basic Science Tower, Stony Brook, NY 11794 8661, USA
    Am J Physiol Cell Physiol 293:C337-45. 2007
    ..oocyte expression system to examine the functional characteristics of a Cx26 mutation (G45E) that results in keratitis-ichthyosis-deafness syndrome (KIDS) with a fatal outcome...
  90. ncbi Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection
    M R Dana
    Cornea Service, Massachusetts Eye and Ear Infirmary and Brigham and Women s Hospital, Boston, USA
    Cornea 19:625-43. 2000
    ..advances in our understanding of the cellular and molecular mechanisms involved in the immunopathogenesis of corneal immunoinflammatory disorders including microbial keratitis, peripheral ulcerative keratitis. and allograft rejection.
  91. ncbi TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 47:4910-6. 2006
    To determine the role of Toll-like receptor 4 (TLR4) in Pseudomonas aeruginosa (P. aeruginosa) keratitis in resistant (cornea-healing) BALB/c mice.
  92. ncbi A new topical model of Staphylococcus corneal infection in the mouse
    Dalia O Girgis
    Department of Microbiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 44:1591-7. 2003
    To establish, in the scarified mouse eye, a new model of Staphylococcus aureus keratitis suitable for studies of pathogenesis and host defense mechanisms.
  93. ncbi Penetrating keratoplasty for corneal perforations in fungal keratitis
    Lixin Xie
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Cornea 26:158-62. 2007
    To evaluate the complications and therapeutic effects of penetrating keratoplasty (PKP) in the treatment of corneal perforations in fungal keratitis.
  94. ncbi The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in South India
    Usha Gopinathan
    Jhaveri Microbiology Center, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Cornea 21:555-9. 2002
    To report the epidemiological features and laboratory results of 1,352 cases of fungal keratitis diagnosed at the L.V. Prasad Eye Institute (LVPEI) in south India.
  95. ncbi Keratitis-ichthyosis-deafness syndrome in association with follicular occlusion triad
    Laura Maintz
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Dermatol 15:347-52. 2005
    b>Keratitis-Ichthyosis-Deafness syndrome is a rare congenital disorder of the ectoderm caused by mutations in the connexin-26 gene (GJB2) on chromosome 13q11-q12, giving rise to keratitis, erythrokeratoderma and neurosensory deafness...
  96. doi Keratitis and corneal scarring after UVA/riboflavin cross-linking for keratoconus
    Carina Koppen
    Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium
    J Refract Surg 25:S819-23. 2009
    To report four cases of severe keratitis after standard corneal collagen cross-linking (CXL) treatment for keratoconus.
  97. ncbi Mycological profile of infectious Keratitis from Delhi
    Rumpa Saha
    Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
    Indian J Med Res 123:159-64. 2006
    Corneal blindness is a major health problem worldwide and infectious keratitis is one of the predominant causes. The incidence of fungal keratitis has increased over the last few years...
  98. pmc Chemokine CXCL1/KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis
    Ashish V Chintakuntlawar
    Molecular Pathogenesis of Eye Infection Research Center, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Interferon Cytokine Res 29:657-66. 2009
    ..Adenoviral keratitis causes significant morbidity to the patients, and is characterized by infiltration of leukocytes in the corneal ..
  99. pmc Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
    Ashok Kumar
    Kresge Eye Institute Department of Ophthalmo, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Infect Immun 76:89-96. 2008
    Pseudomonas aeruginosa is a common organism associated with bacterial keratitis, especially in extended-wear contact lens users...
  100. pmc Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88
    Yan Sun
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:5325-32. 2006
    ..Toll-like receptors (TLRs) expressed by the corneal epithelium represent a first line of host defense to microbial keratitis. The current study examined the role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid ..
  101. ncbi Spider keratouveitis. A case report
    F D Sandboe
    Eye Department, Rikshospitalet University Hospital, Oslo, Norway
    Acta Ophthalmol Scand 79:531-2. 2001
    ..CONCLUSION: Hairs from pet tarantulas might penetrate deeply into the eye and give keratouveitis. The hairs might be difficult to detect. Though rare, this phenomenon should be known by both ophthalmologists and the public...

Research Grants81

  1. Mechanisms of Epithelial Alterations in Diabetic Cornea
    Alexander Ljubimov; Fiscal Year: 2009
    ..abnormal barrier function, defects and recurrent erosions, debridement after vitrectomy, delayed wound healing, keratitis, and edema), as well as neuropathy...
  2. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
    ..response found in the draining lymph node reflected by the severity in the development of herpetic stromal keratitis of HSV-1 infected mice...
  3. OCULAR DISPOSITION OF ACYCLOGUANOSINE ANALOGUES
    Ashim Mitra; Fiscal Year: 2005
    ..have shown excellent in vitro antiviral activity against HSV 1 in HFF cells and in vivo rabbit epithelial keratitis with no measurable cytotoxicity...
  4. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2010
    Herpes simplex virus (HSV) keratitis is a leading cause of non-traumatic blindness in developed countries, with more than 400,000 cases in the USA, with approximately 50,000 new and recurring cases per year...
  5. Ocular Disposition of Antimicrobial Agents
    Ashim Mitra; Fiscal Year: 2009
    ..antimicrobial agents employed in the treatment of both bacterial and viral corneal stromal and epithelial keratitis. In this grant proposal we aim to characterize the ascorbate carrier systems expressed on the corneal membrane...
  6. Ocular Disposition of Antimicrobial Agents
    Ashim Mitra; Fiscal Year: 2007
    ..antimicrobial agents employed in the treatment of both bacterial and viral corneal stromal and epithelial keratitis. In this grant proposal we aim to characterize the ascorbate carrier systems expressed on the corneal membrane...
  7. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..antimicrobial agents employed in the treatment of both bacterial and viral corneal stromal and epithelial keratitis. In this grant proposal we aim to characterize the ascorbate carrier systems expressed on the corneal membrane...
  8. Herpes simplex virus egress from cells and spread in neuronal axons
    David C Johnson; Fiscal Year: 2010
    ..HSV can trigger an inflammatory disease in the cornea, known as herpes stromal keratitis (HSK) in which repeated reinfection of the cornea, over time, leads to progressive scarring in the corneal ..
  9. Herpes simplex virus egress from cells and spread in neuronal axons
    David C Johnson; Fiscal Year: 2010
    ..HSV can trigger an inflammatory disease in the cornea, known as herpes stromal keratitis (HSK) in which repeated reinfection of the cornea, over time, leads to progressive scarring in the corneal ..
  10. Staph keratitis: mechanism and arrest of ocular damage
    RICHARD JOSEPH O apos CALLAGHAN; Fiscal Year: 2010
    ....
  11. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2010
    Acanthamoeba keratitis (AK) is a serious, debilitating, and intensely painful infection of the cornea caused by parasites of the genus Acanthamoeba...
  12. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..on the mechanism(s) by which HSV infections induce corneal edema, the most common complication of herpetic keratitis. We propose that HSV-induced edema results from inhibition of corneal endothelial cell Na+K+ATPase by products ..
  13. Novel Corneal Implant Materials
    Shiao Chang; Fiscal Year: 2006
    ..and under-correction, regression, flap complications, glare, haloes, reduced night vision, diffuse lamellar keratitis, dry eye, and inability to correct predictably large hyperopic and myopic refractive errors...
  14. Bacteria-Mucin Interactions at the Ocular Surface
    Ilene K Gipson; Fiscal Year: 2010
    ..Examples of the first are Staphylococcus aureus (SA) or Streptococcus pneumoniae (SPE) (encapsulated) keratitis that occurs as the result of epithelial surface damage from trauma. Other types of infection, e.g...
  15. DNA Probes for Acanthamoeba Genomics and Epidemiology
    Paul Fuerst; Fiscal Year: 2007
    ..pathogenic protist Acanthamoeba, the causative agent of the sight-threatening disease Acanthamoeba keratitis (AK)...
  16. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2007
    ..BAY 57-1293 will be compared with acyclovir and trifluridine to determine its efficacy in models of epithelial keratitis, stromal keratitis, and iritis and to determine if BAY 57-1293 can prevent recurrences of herpes when ..
  17. Ocular HSV-Latency, Reactivation, and Recurrence
    James Hill; Fiscal Year: 2009
    ..In the USA, 300,000 cases are treated yearly. Ocular HSV causes a self-limiting epithelial keratitis, blepharitis, con- junctivitis, stromal keratitis, and the most damaging disease, necrotizing herpetic stromal ..
  18. Ocular HSV-Latency, Reactivation, and Recurrence
    James M Hill; Fiscal Year: 2010
    ..In the USA, 300,000 cases are treated yearly. Ocular HSV causes a self-limiting epithelial keratitis, blepharitis, con- junctivitis, stromal keratitis, and the most damaging disease, necrotizing herpetic stromal ..
  19. Role of HSV Induced RNA Degradation in Pathogenesis
    David Leib; Fiscal Year: 2006
    Herpes simplex virus (HSV) keratitis is a leading cause of non-traumatic blindness in developed countries, with more than 200,000 cases per year in the USA...
  20. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 1993
    We shall attempt to elucidate the mechanism of the development of Acanthamoeba keratitis by examining the plasma membrane molecules of corneal epithelium and Acanthamoeba...
  21. IDENTIFY LIMBAL STEM CELLS BY CELL SURFACE MARKERS
    Ronald Smith; Fiscal Year: 2005
    ..aniridia, pterygium, herpes simplex epithelial disease contact lens induced keratopathy, neuroparalytic keratitis, drug toxicity, or multiple surgical procedures in the corneolim region and may lead to loss of limbal stem ..
  22. SIGNIFICANCE OF CORNEAL CELL INVASION BY BACTERIA
    Suzanne Fleiszig; Fiscal Year: 1999
    ..is to understand the role of corneal cell invasion by bacteria in the pathogenesis of bacterial infectious keratitis due to Pseudomonas aeruginosa, and to develop strategies for treatment and/or prevention of this disease...
  23. STRUCTURAL STUDIES OF HERPESVIRUS CAPSIDS
    Wah Chiu; Fiscal Year: 1999
    ..In more severe cases, HSV-1 may cause herpes keratitis (leading to sight impairment) or a potentially fatal encephalitis...
  24. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1993
    ..adapted from applicant's abstract): The objective is to investigate the ocular pathogenesis of bacterial keratitis with the goal of limiting by chemotherapy the bacterial and host factors that produce stromal damage...
  25. Immunopathogenesis of Adenovirus Keratitis
    James Chodosh; Fiscal Year: 2009
    ..by acute pseudomembranous conjunctivitis, punctate and macro-epithelial erosions, and delayed onset stromal keratitis. In EKC, the delayed infiltration of leukocytes into the subepithelial corneal stroma causes prolonged and ..
  26. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    Recurrent herpes stromal keratitis (HSK) remains the major cause of infectious blinding disease in the US, with the only effective treatment being corneal transplantation...
  27. Biofilm Formation And P. aeruginosa infection of the eye
    Michael Zegans; Fiscal Year: 2006
    ..Pseudomonas aeruginosa (PA) is one of the most common causes of bacterial keratitis. The central hypothesis of this proposal is that biofilm formation plays an important role in the pathogenesis ..
  28. MECHANISMS AND THERAPY OF BACTERIAL KERATITIS
    RICHARD O CALLAGHAN; Fiscal Year: 2000
    DESCRIPTION: (from abstract). Bacterial keratitis can result in blindness or a loss of visual acuity through a pathologic process that involves the interaction of bacteria, their products, and the host reaction to bacterial proteins...
  29. VIRAL & HOST FACTORS IN HERPETIC REACTIVATION
    David A Leib; Fiscal Year: 2010
    Herpes simplex virus (HSV) keratitis is a leading cause of non-traumatic blindness in developed countries, with more than 200,000 cases per year in the USA...