keratitis

Summary

Summary: Inflammation of the cornea.

Top Publications

  1. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
  2. pmc ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 188:1884-95. 2012
  3. pmc Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome
    Helmuth A Sánchez
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gen Physiol 136:47-62. 2010
  4. pmc Effect of femtosecond laser energy level on corneal stromal cell death and inflammation
    Fabricio Witzel de Medeiros
    Cleveland Clinic, Cole Eye Institute, Ohio 44195, USA
    J Refract Surg 25:869-74. 2009
  5. pmc Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium
    Rajapandian Sivaganesa Karthikeyan
    Dr G Venkatasamy Eye Research Institute, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    J Infect Dis 204:942-50. 2011
  6. ncbi Microbial keratitis: aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia
    T J Norina
    Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
    Singapore Med J 49:67-71. 2008
  7. pmc Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review
    Loretta B Szczotka-Flynn
    Departmentsof Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Eye Contact Lens 36:116-29. 2010
  8. pmc Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade
    Usha Gopinathan
    Jhaveri Microbiology Centre, Prof Brien Holden Eye Research Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Prasad Marg, Banjara Hills, Hyderabad, India
    Indian J Ophthalmol 57:273-9. 2009
  9. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
  10. pmc Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
    T Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Br J Ophthalmol 87:834-8. 2003

Detail Information

Publications286 found, 100 shown here

  1. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
    ..that colonize lenses can lead to infection and inflammation, but the most common cause of infection (microbial keratitis; MK) remains the Gram-negative bacterium Pseudomonas aeruginosa. P...
  2. pmc ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 188:1884-95. 2012
    ..To determine the role of type III secretion in the pathogenesis of P. aeruginosa keratitis, corneas of C57BL/6 mice were infected with P...
  3. pmc Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome
    Helmuth A Sánchez
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gen Physiol 136:47-62. 2010
    ..two such mutations, A40V and G45E, which are positioned near the TM1/E1 boundary and are associated with keratitis ichthyosis deafness (KID) syndrome...
  4. pmc Effect of femtosecond laser energy level on corneal stromal cell death and inflammation
    Fabricio Witzel de Medeiros
    Cleveland Clinic, Cole Eye Institute, Ohio 44195, USA
    J Refract Surg 25:869-74. 2009
    ..To analyze the effects of variations in femtosecond laser energy level on corneal stromal cell death and inflammatory cell influx following flap creation in a rabbit model...
  5. pmc Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium
    Rajapandian Sivaganesa Karthikeyan
    Dr G Venkatasamy Eye Research Institute, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    J Infect Dis 204:942-50. 2011
    ..Filamentous fungi of the genera Aspergillus and Fusarium are major causes of corneal ulcers in the United States and in the developing world and result in significant visual impairment and blindness...
  6. ncbi Microbial keratitis: aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia
    T J Norina
    Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
    Singapore Med J 49:67-71. 2008
    ..Our objective is to determine the epidemiological characteristics, clinical features, risk factors and the aetiology of microbial keratitis in patients admitted to Hospital Universiti Sains Malaysia (HUSM).
  7. pmc Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review
    Loretta B Szczotka-Flynn
    Departmentsof Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Eye Contact Lens 36:116-29. 2010
    ..In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection...
  8. pmc Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade
    Usha Gopinathan
    Jhaveri Microbiology Centre, Prof Brien Holden Eye Research Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Prasad Marg, Banjara Hills, Hyderabad, India
    Indian J Ophthalmol 57:273-9. 2009
    To review the epidemiological characteristics, microbiological profile, and treatment outcome of patients with suspected microbial keratitis.
  9. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ..To enhance our understanding of the pathogenesis of Aspergillus keratitis, we developed a murine model in which red fluorescent protein (RFP)-expressing A. fumigatus (Af293...
  10. pmc Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
    T Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Br J Ophthalmol 87:834-8. 2003
    To identify predisposing factors and to define clinical and microbiological characteristics of bacterial keratitis in current practice.
  11. ncbi Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
    Pseudomonas aeruginosa (P. aeruginosa) is a common organism associated with bacterial keratitis, especially in those who use extended wear contact lenses...
  12. ncbi Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4
    Saloni Khatri
    Department of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106 4983, USA
    Invest Ophthalmol Vis Sci 43:2278-84. 2002
    ..LPS, endotoxin) is a potent stimulator of inflammatory responses and is likely to contribute to microbial keratitis and to the pathogenesis of sterile corneal ulcers...
  13. pmc Topical flagellin protects the injured corneas from Pseudomonas aeruginosa infection
    Ashok Kumar
    Departments of Ophthalmology and Anatomy and Cell Biology, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St Antoine, Detroit, MI 48201, USA
    Microbes Infect 12:978-89. 2010
    ..aeruginosa. Using a mouse model of Pseudomonas keratitis, we evaluated the protective effects of topical application of flagellin, a ligand for Toll-Like receptor 5 (..
  14. ncbi Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and North America
    D S C Lam
    Department of Ophthalmology and Visual Sciences, Prince of Wales and Hong Kong Eye Hospitals, The Chinese University of Hong Kong, People s Republic of China
    Eye (Lond) 16:608-18. 2002
    To establish the incidence, etiology and risk factors for microbial keratitis (MK) in Hong Kong.
  15. ncbi Early diagnosis of amoebic keratitis due to a mixed infection with Acanthamoeba and Hartmannella
    Jacob Lorenzo-Morales
    University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda Astrofísico Fco Sánchez, S N, 38203, La Laguna, Tenerife, Canary Islands, Spain
    Parasitol Res 102:167-9. 2007
    A mixed keratitis due to Acanthamoeba and Hartmannella species is reported. The patient was a soft contact lens wearer. Early diagnosis was achieved by polymerase chain reaction and culture...
  16. pmc Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease
    J H Chang
    School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Br J Ophthalmol 90:103-8. 2006
    ..agents have an important role in the pathogenesis of various inflammatory eye diseases, such as uveitis and keratitis. Microbial infections of the eye such as microbial keratitis, ocular onchocerciasis, bacterial endophthalmitis, ..
  17. ncbi Early corneal wound healing and inflammatory responses after refractive lenticule extraction (ReLEx)
    Andri K Riau
    Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 52:6213-21. 2011
    ..To compare the early corneal wound repair and inflammatory responses after refractive lenticule extraction (ReLEx) and LASIK...
  18. pmc Contact lens-related microbial keratitis: how have epidemiology and genetics helped us with pathogenesis and prophylaxis
    F Stapleton
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Eye (Lond) 26:185-93. 2012
    Contact lens wear is a common predisposing factor in microbial keratitis and is one of the two preventable risk factors for corneal infection in a working age population...
  19. ncbi The role of secreted aspartyl proteinases in Candida albicans keratitis
    Beth E Jackson
    Department of Ophthalmology, Sid W Richardson Ocular Microbiology Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Invest Ophthalmol Vis Sci 48:3559-65. 2007
    To evaluate virulence in a murine keratitis model using Candida albicans homozygous mutants deficient in one or more secreted aspartyl proteinases encoded by SAP genes or in transcriptional factors encoded by EFG1 and CPH1 genes.
  20. ncbi Beta-defensin-2 promotes resistance against infection with P. aeruginosa
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 182:1609-16. 2009
    ..Collectively, the data provide evidence that mBD2, but not mBD1, is required for host resistance against P. aeruginosa-induced corneal infection...
  21. ncbi Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)
    Karim Makdoumi
    Department of Ophthalmology, Orebro University Hospital, Orebro, Sweden
    Graefes Arch Clin Exp Ophthalmol 248:207-12. 2010
    To evaluate the antibacterial efficacy of photo-activated riboflavin using Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis.
  22. ncbi Determination of quorum-sensing signal molecules and virulence factors of Pseudomonas aeruginosa isolates from contact lens-induced microbial keratitis
    Hua Zhu
    Cooperative Research Center for Eye Research and Technology, University of New South Wales, UNSW, Sydney, NSW 2052, Australia
    J Med Microbiol 51:1063-70. 2002
    The virulence of Pseudomonas aeruginosa in contact lens-induced microbial keratitis has been linked to various extracellular and cell-associated bacterial products, such as proteases and toxins...
  23. ncbi Corneal cross-linking as supplementary treatment option in melting keratitis: a case series
    L Muller
    Department of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland
    Klin Monbl Augenheilkd 229:411-5. 2012
    ..Recently, corneal cross-linking (CXL) has emerged as an additional treatment option. The present study evaluates whether CXL induces a clinical improvement in melting keratitis not responding to conventional treatment.
  24. ncbi Candida parapsilosis keratitis
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Cornea 22:51-5. 2003
    To present clinical, microbiologic, and histopathologic features of keratitis due to Candida parapsilosis.
  25. ncbi Late bacterial keratitis after implantation of intrastromal corneal ring segments
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    J Cataract Refract Surg 29:407-9. 2003
    We report a case of bacterial keratitis that occurred after implantation of intrastromal corneal ring segments (Intacs)...
  26. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002
    To evaluate the outcome of corneal grafting in patients with stromal keratitis of herpetic (HSK) and non-herpetic origin, using predefined diagnostic criteria and standardised postoperative therapeutic strategies.
  27. ncbi Analysis of the risk factors predisposing to fungal, bacterial & Acanthamoeba keratitis in south India
    M Jayahar Bharathi
    Microbiology Research Centre, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli 627 001, Tamil Nadu, India
    Indian J Med Res 130:749-57. 2009
    Infective keratitis is rare in the absence of predisposing factors. The pattern of risk factors predisposing to infective keratitis varies with geographical regions and also influences the type of infection that occurs...
  28. pmc Severe infective keratitis leading to hospital admission in New Zealand
    T Wong
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Br J Ophthalmol 87:1103-8. 2003
    To identify key risk factors and the management and outcome of severe infective keratitis leading to public hospital admission in New Zealand.
  29. ncbi Riboflavin and ultraviolet a collagen crosslinking of the cornea for the treatment of keratitis
    Håkan Morén
    Department of Ophthalmology, Regional Hospital of Västerås, Vasteras, Sweden
    Cornea 29:102-4. 2010
    To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis.
  30. pmc TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 185:4272-83. 2010
    ..Using a murine model of keratitis in which abraded corneas are infected with P...
  31. ncbi A femtosecond laser creates a stronger flap than a mechanical microkeratome
    Jae Yong Kim
    Department of Ophthalmology and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Invest Ophthalmol Vis Sci 47:599-604. 2006
    ..To compare corneal flaps made with a femtosecond (FS) laser with those made with a mechanical microkeratome (MM) in rabbits, measuring early postoperative inflammation and apoptosis and late postoperative adhesion strength...
  32. ncbi Spectrum of microbial keratitis in South Florida
    T J Liesegang
    Am J Ophthalmol 90:38-47. 1980
    During a nine-year period ending in 1977, we scraped and cultured 663 corneal ulcers. Of these cases of keratitis, 238 were bacterial infections, 133 were fungal, and 292 were culture-negative...
  33. ncbi TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 47:4910-6. 2006
    To determine the role of Toll-like receptor 4 (TLR4) in Pseudomonas aeruginosa (P. aeruginosa) keratitis in resistant (cornea-healing) BALB/c mice.
  34. pmc Femtosecond laser and microkeratome corneal flaps: comparison of stromal wound healing and inflammation
    Marcelo V Netto
    The Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 23:667-76. 2007
    ..To examine early postoperative wound healing in rabbit corneas that had LASIK flaps formed with three different models (15 KHz, 30 KhZ, and 60 KHz) of a femtosecond laser compared with flaps formed with a microkeratome...
  35. pmc Phototoxicity and the cornea
    O D Schein
    Massachusetts Eye and Ear Infirmary, Boston
    J Natl Med Assoc 84:579-83. 1992
    ..Ultraviolet keratitis is associated with relatively short exposures to light sources such as welding arcs or tanning lamps...
  36. pmc Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury
    Joo Youn Oh
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, TX 76502, USA
    Proc Natl Acad Sci U S A 107:16875-80. 2010
    ..The data indicated that TSG-6, a therapeutic protein produced by MSCs in response to injury signals, can protect the corneal surface from the excessive inflammatory response following injury...
  37. pmc Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis
    Ashish V Chintakuntlawar
    University of Oklahoma Health Sciences Center, Department of Ophthalmology, Oklahoma City, Oklahoma, United States of America
    PLoS Pathog 6:e1000841. 2010
    ..Using a unique mouse model of adenovirus keratitis, we studied the role of various virus-associated molecular patterns in subsequent innate immune responses of ..
  38. ncbi Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness
    Dwan A Gerido
    Dept of Physiology and Biophysics, State University of New York, T5 147, Basic Science Tower, Stony Brook, NY 11794 8661, USA
    Am J Physiol Cell Physiol 293:C337-45. 2007
    ..oocyte expression system to examine the functional characteristics of a Cx26 mutation (G45E) that results in keratitis-ichthyosis-deafness syndrome (KIDS) with a fatal outcome...
  39. pmc Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis
    A K Leck
    Department of Infectious and Tropical Diseases, Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 86:1211-5. 2002
    A multicentre study was carried out in Ghana and southern India to determine the aetiology of suppurative keratitis in two regions located at similar tropical latitudes. Studies of fungal keratitis from the literature were reviewed.
  40. pmc Phylogenetic diversity and microsphere array-based genotyping of human pathogenic Fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006
    Kerry O'Donnell
    Microbial Genomics and Bioprocessing Research Unit, Agricultural Research Service, U S Department of Agriculture, 1815 North University Street, Peoria, IL 61604 3999, USA
    J Clin Microbiol 45:2235-48. 2007
    In 2005 and 2006, outbreaks of Fusarium keratitis associated with soft contact lens use occurred in multiple U.S. states and Puerto Rico...
  41. ncbi Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study
    Leonardo Mastropasqua
    Department of Medicine and Aging Science, Ophthalmic Clinic, University of Chieti Pescara, Chieti, Italy
    Am J Ophthalmol 142:736-44. 2006
    ..To evaluate dendritic cell (DCs) density, distribution, and morphology in central corneal and limbal epithelium in normal subjects and patients with immune-mediated corneal inflammation using in vivo confocal microscopy (IVCM)...
  42. ncbi Recurrent Alcaligenes xylosoxidans keratitis
    Zei Lun Huang
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China
    Cornea 24:489-90. 2005
    To describe a case of postkeratoplasty recurrent Alcaligenes xylosoxidans keratitis.
  43. ncbi Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes
    Jack R Lee
    Department of Physiology and Biophysics, Stony Brook University Medical Center, Stony Brook, New York 11794 8661, USA
    J Invest Dermatol 129:870-8. 2009
    ..This set of data confirms that aberrant hemichannel activity is a common feature of Cx26 mutations associated with KID syndrome, and this may contribute to a loss of cell viability and tissue integrity...
  44. ncbi Corneal endotheliitis associated with evidence of cytomegalovirus infection
    Soon Phaik Chee
    Singapore National Eye Centre, Singapore
    Ophthalmology 114:798-803. 2007
    ..To describe the clinical presentation of cytomegalovirus (CMV) corneal endotheliitis in human immunodeficiency virus (HIV)-negative patients...
  45. ncbi Infectious keratitis following keratoplasty
    Rasik B Vajpayee
    Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Surv Ophthalmol 52:1-12. 2007
    Infectious keratitis following corneal transplantation is one of the leading causes of failure of a corneal graft. The incidence of graft infection is variable, with developing countries having a higher incidence...
  46. ncbi A multi-country outbreak of fungal keratitis associated with a brand of contact lens solution: the Hong Kong experience
    Siu keung Edmond Ma
    Surveillance and Epidemiology Branch, Centre for Health Protection, Department of Health, 147C Argyle Street, Kowloon, Hong Kong Special Administrative Region
    Int J Infect Dis 13:443-8. 2009
    Starting in mid-2005, an increase in fungal keratitis caused by Fusarium spp was observed among contact lens wearers in Hong Kong, Singapore, and the USA...
  47. pmc Infective keratitis in older patients: a 4 year review, 1998-2002
    T K H Butler
    Department of Clinical Ophthalmology and Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia
    Br J Ophthalmol 89:591-6. 2005
    There are few clinical series in the literature of infective keratitis in the elderly, even though this age group constitutes a significant proportion of those affected by this condition...
  48. ncbi Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
    Nat Med 10:813-5. 2004
    ..Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery...
  49. ncbi Outbreak of contact lens-related Fusarium keratitis in France
    Thomas Gaujoux
    Service 5, centre hospitalier national d ophtalmologie des XV XX, Universite Pierre et Marie Curie Paris 6, Paris, France
    Cornea 27:1018-21. 2008
    In the context of a recent series of Fusarium keratitis cases in Singapore and the United States, we describe an outbreak of fungal keratitis attributable to Fusarium species among contact lens wearers in France.
  50. ncbi Peripheral keratitis following laser in situ keratomileusis
    William J Lahners
    Center for Sight, Sarasota, FL 34238, USA
    J Refract Surg 19:671-5. 2003
    To report two different cases of sterile, peripheral keratitis following laser in situ keratomileusis (LASIK).
  51. ncbi Neurotrophic keratitis
    S Bonini
    Laboratory of Ophthalmology, Interdisciplinary Center for Biomedical Research, University of Rome, Rome, Italy
    Eye (Lond) 17:989-95. 2003
    ..Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented...
  52. pmc Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1
    Eric C Carlson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:35502-9. 2007
    ..in corneal inflammation, we examined Kera(-/-) and Lum(-/-) mice in a model of lipopolysaccharide (LPS)-induced keratitis in which wild-type mice develop increased corneal thickness and haze due to neutrophil infiltration to the ..
  53. ncbi Contribution of ExsA-regulated factors to corneal infection by cytotoxic and invasive Pseudomonas aeruginosa in a murine scarification model
    Ellen J Lee
    Morton D Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California 94720, USA
    Invest Ophthalmol Vis Sci 44:3892-8. 2003
    ..In the present study, the contribution of these ExsA-regulated proteins toward corneal infections in vivo was investigated...
  54. ncbi Surgically induced corneal necrotizing keratitis following LASIK in a patient with inflammatory bowel disease
    Glenn I Carp
    London Vision Clinic, London, United Kingdom
    J Cataract Refract Surg 36:1786-9. 2010
    We describe a case of necrotizing keratitis that developed after laser in situ keratomileusis (LASIK) in a 50-year-old woman with inflammatory bowel disease...
  55. pmc Insect wing tarsal foreign body causing conjunctival granuloma and marginal keratitis
    Kalpana Babu
    Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Center, Bangalore, India
    Indian J Ophthalmol 57:473-4. 2009
    A 37 year old male was referred to our centre for management of episcleritis with peripheral keratitis in the right eye. He had a history of ocular discomfort in the right eye of 1 week duration...
  56. ncbi Microbial keratitis after LASIK
    Prashant Garg
    Cornea and Anterior Segment Service and Jhaveri Microbiology Center, L V Prasad Eyes Institute, Hyperabad, India
    J Refract Surg 26:209-16. 2010
    To report cases of microbial keratitis after LASIK from a tropical climatic zone.
  57. ncbi Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, IN 46260, USA
    J Refract Surg 28:706-13. 2012
    To evaluate riboflavin/ultraviolet-A (UVA) as an adjunct treatment for infectious keratitis.
  58. ncbi The use of topical honey in the treatment of corneal abrasions and endotoxin-induced keratitis in an animal model
    Sami Uwaydat
    Department of Ophthalmology, Jones Eye Institute, Little Rock, Arkansas 72205, USA
    Curr Eye Res 36:787-96. 2011
    To investigate the effect of topically applied honey on intact corneas, surgically induced corneal abrasions and endotoxin induced keratitis.
  59. ncbi β-Catenin promotes host resistance against Pseudomonas aeruginosa keratitis
    Kang Chen
    Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, China Key Laboratory of Tropical Diseases Control Sun Yat sen University, Ministry of Education, Guangzhou 510080, China Division of Clinical Laboratory, Zhongshan Hospital of Sun Yat sen University, Zhongshan 528403, China
    J Infect 67:584-94. 2013
    To explore the role of β-catenin in Pseudomonas aeruginosa (PA) keratitis.
  60. pmc Achromobacter xylosoxidans keratitis after contact lens usage
    Jung Hyun Park
    Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea
    Korean J Ophthalmol 26:49-53. 2012
    To report on Achromobacter xylosoxidans keratitis in two healthy patients who had worn contact lenses foran extended period of time. A 36-year-old female and a 21-year-old female visited our hospital with ocular pain and blurred vision...
  61. ncbi Short-term cell death and inflammation after intracorneal inlay implantation in rabbits
    Marcony R Santhiago
    The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 28:144-9. 2012
    ..To investigate the cell death and inflammatory response to insertion of the KAMRA inlay (AcuFocus Inc) for presbyopia...
  62. pmc Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections
    Rosalind M K Stewart
    Institute of Infection and Global Health, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    J Clin Microbiol 49:993-1003. 2011
    ..aeruginosa isolates from patients with corneal ulcers (keratitis). We then used population analysis to compare the keratitis isolates to a wider collection of P...
  63. ncbi Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis
    R Kawaguchi
    Second Department of Ophthalmology, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan
    Cornea 20:100-3. 2001
    PURPOSE: A web-like retrocorneal membrane (RCM) is an uncommon complication of chronic syphilitic interstitial keratitis. Extracellular matrix components have not yet been defined in this structure, although previous histologic ..
  64. ncbi Mycotic keratitis: epidemiology, diagnosis and management
    P A Thomas
    Department of Ocular Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, India
    Clin Microbiol Infect 19:210-20. 2013
    Mycotic keratitis (an infection of the cornea) is an important ocular infection, especially in young male outdoor workers...
  65. pmc Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis
    Jaya Rajaiya
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:2879-89. 2009
    ..Therefore, we sought to better understand the differential regulation of chemokine expression by NFkappaB in adenoviral infection of the cornea...
  66. ncbi Clinical, microbiological profile and treatment outcome of ocular infections caused by Achromobacter xylosoxidans
    Ashok Kumar Reddy
    Jhaveri Microbiology Centre, Hyderabad Eye Research Foundation, India
    Cornea 28:1100-3. 2009
    ..To study the microbiological profile and outcome of ocular infections caused by Achromobacter xylosoxidans...
  67. ncbi Multiple drug-resistant Alcaligenes xylosoxidans keratitis in a sanitation worker
    Daniel F Kiernan
    Department of Ophthalmology and Visual Science, University of Chicago, IL 60637, USA
    Eye Contact Lens 35:212-4. 2009
    To report a case of daily wear soft contact lens-associated keratitis caused by Alcaligenes xylosoxidans in a portable toilet sanitation worker.
  68. pmc Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection
    Megan E B Foldenauer
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 190:5649-58. 2013
    ..of rapamycin (mTOR) regulates IL-10 in other disease models, the present study tested its role in bacterial keratitis. After infection, corneas of rapamycin versus control-treated BALB/c mice showed worsened disease, and real-time ..
  69. pmc Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome
    Gabriele Richard
    Department of Dermatology and Cutaneous Biology and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hum Genet 70:1341-8. 2002
    b>Keratitis-ichthyosis-deafness syndrome (KID) is a rare ectodermal dysplasia characterized by vascularizing keratitis, profound sensorineural hearing loss (SNHL), and progressive erythrokeratoderma, a clinical triad that indicates a ..
  70. ncbi Ultrastructural analysis of slime positive & slime negative Staphylococcus epidermidis isolates in infectious keratitis
    N Nayak
    Department of Ocular Microbiology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 125:767-71. 2007
    ....
  71. ncbi Optimizing diagnosis and management of nocardia keratitis, scleritis, and endophthalmitis: 11-year microbial and clinical overview
    Francis Char Decroos
    Duke University Eye Center, Durham, North Carolina, USA
    Ophthalmology 118:1193-200. 2011
    To identify clinical factors and microbiological assays that facilitate a rapid diagnosis of Nocardia keratitis, scleritis, and endophthalmitis, and to determine optimal medical and surgical management strategies.
  72. ncbi Contact lens-associated microbial keratitis
    Aline Silveira Moriyama
    Department of Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Bras Oftalmol 71:32-6. 2008
    Contact lens-associated microbial keratitis is a severe condition with sight-threatening potential and increasing incidence. Information regarding the etiological agents is essential in guiding management and may vary geographically...
  73. ncbi Keratitis
    S Sharma
    Jhaveri Microbiology Centre, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, AP, India
    Biosci Rep 21:419-44. 2001
    Corneal inflammation or keratitis is a significant cause of ocular morbidity around the world...
  74. ncbi Characteristics of and risk factors for contact lens-related microbial keratitis in a tertiary referral hospital
    K Edwards
    School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia
    Eye (Lond) 23:153-60. 2009
    A retrospective case-control study was conducted at a tertiary referral hospital to determine the characteristics of and risk factors for contact lens (CL) related presumed microbial keratitis.
  75. ncbi Clinical characteristics of microbial keratitis in a university hospital in Taiwan
    Chien Fan Fong
    Department of Ophthalmology, Hsin Chu Hospital, Hsin Chu, Taiwan
    Am J Ophthalmol 137:329-36. 2004
    To analyze the clinical and microbiological characteristics of microbial keratitis at the National Taiwan University Hospital in the preceding 10 years.
  76. ncbi Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins
    Mark D P Willcox
    School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
    Clin Exp Optom 94:161-8. 2011
    Microbial keratitis is a rare disease but most commonly caused by bacterial infection. Two of the most common bacteria to cause microbial keratitis are Pseudomonas aeruginosa and Staphylococcus aureus...
  77. pmc Moxifloxacin and cholesterol combined treatment of pneumococcal keratitis
    Melissa E Sanders
    Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Curr Eye Res 35:1142-7. 2010
    Compare the efficacy of treatment of pneumococcal keratitis with cholesterol, moxifloxacin, or a mixture of the two (moxifloxacin/cholesterol).
  78. ncbi Role of innate and adaptive immunity in the pathogenesis of keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:133-8. 2005
    Pseudomonas aeruginosa is a common organism associated with bacterial keratitis primarily resulting from contact lens usage...
  79. ncbi Fungal keratitis: changing pathogens and risk factors
    Ula Jurkunas
    Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Cornea 28:638-43. 2009
    To describe changes in demographics and pathogens for fungal keratitis cases diagnosed at the Massachusetts Eye and Ear Infirmary.
  80. ncbi Microbial keratitis in the elderly: a 32-year review
    Renato Magalhães Passos
    Ophthalmology Department, Escola Paulista de Medicina, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Arq Bras Oftalmol 73:315-9. 2010
    To describe the demographic characteristics, associated factors and causative agents of infectious keratitis in the elderly in a tertiary referral center in São Paulo, Brazil.
  81. ncbi Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing
    Nobuyuki Ebihara
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:8549-57. 2011
    ..To investigate the role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing...
  82. ncbi Phototherapeutic keratectomy in treating keratomycosis
    Chang Ping Lin
    Department of Ophthalmology, Changhua Christian Hospital, Taiwan
    Cornea 24:262-8. 2005
    ..To evaluate the efficacy of using phototherapeutic keratectomy (PTK) in the treatment of superficial keratomycosis...
  83. ncbi Study of the first contact management profile of cases of infectious keratitis: a hospital-based study
    R B Vajpayee
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Cornea 19:52-6. 2000
    To study the management pattern and examine the role of cultures and antibiotic sensitivity testing in infectious keratitis.
  84. pmc Initial therapy for suppurative microbial keratitis in Iraq
    Faiz Al-Shakarchi
    Ibn Al Haetham Teaching Eye Hospital, BGW, Baghdad, Iraq
    Br J Ophthalmol 91:1583-7. 2007
    To provide data-based guidelines for selection of an appropriate initial therapy for management suppurative microbial keratitis (SMK) in Iraq.
  85. ncbi Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmannella infection
    D Aitken
    Department of Ophthalmology, University of Glasgow, Scotland
    Ophthalmology 103:485-94. 1996
    To support the hypothesis that Acanthamoeba is not a unique cause of amebic keratitis, we report a case of amebic keratitis in which viable Acanthamoeba could not be isolated from corneal tissue...
  86. ncbi Candida parapsilosis keratitis following treatment of epithelial ingrowth after laser in situ keratomileusis
    Renee Solomon
    Ophthalmic Consultants of Long Island, Rockville Centre, NY 11570, USA
    Eye Contact Lens 30:85-6. 2004
    ..To present a case of Candida parapsilosis following laser in situ keratomileusis (LASIK)...
  87. ncbi Epidemiology and medical prediction of microbial keratitis in southeast Brazil
    Marlon Moraes Ibrahim
    Department of Ophthalmology, Ribeirao Preto Medical School, Sao Paulo University, Avenida Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    Arq Bras Oftalmol 74:7-12. 2011
    The goals of the study were the following: 1) to show the epidemiology of microbial keratitis (MK) in the southeast Brazil, 2) to compare the epidemiological differences between fungal (FK) and bacterial keratitis (BK), and 3) to ..
  88. ncbi Delayed-onset multifocal polymicrobial keratitis after laser in situ keratomileusis
    David Ritterband
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    J Cataract Refract Surg 28:898-9. 2002
    We report a case of mixed Aspergillus fumigatus and coagulase-negative Staphylococcus stromal keratitis in a 43-year-old man who developed discomfort and swelling in his right eye 20 days after uneventful bilateral laser in situ ..
  89. pmc Geographic variations in microbial keratitis: an analysis of the peer-reviewed literature
    Ameet Shah
    Moorfields Eye Hospital, London, UK
    Br J Ophthalmol 95:762-7. 2011
    The epidemiology of microbial keratitis has been investigated in several studies by analysis of organisms cultured from corneal scrapes...
  90. ncbi Immunity to lysostaphin and its therapeutic value for ocular MRSA infections in the rabbit
    Joseph J Dajcs
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center in New Orleans, New Orleans 70112, USA
    Invest Ophthalmol Vis Sci 43:3712-6. 2002
    ..To determine the effects of immunization against lysostaphin on the bactericidal action of lysostaphin in ocular tissue and the possible induction of allergic reactions...
  91. ncbi Topical cyclosporin A in the management of therapeutic keratoplasty for mycotic keratitis
    Henry D Perry
    Department of Ophthalmology, North Shore University Hospital, Long Island Jewish Medical Center, Great Neck, New York, U S A
    Cornea 21:161-3. 2002
    To investigate the efficacy of topical cyclosporine A 0.5% as a substitute for corticosteroids in the management of therapeutic keratoplasties for mycotic keratitis.
  92. ncbi Medical treatment for combined Fusarium and Acanthamoeba keratitis
    Hsin Chiung Lin
    Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan
    Acta Ophthalmol 87:199-203. 2009
    Acanthamoeba and fungal keratitis are rare ocular infections. We report cases of combined Fusarium and Acanthamoeba keratitis and the clinical course of medical treatment.
  93. ncbi Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis
    Man H Choy
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    J Med Microbiol 57:1539-46. 2008
    ..is one of the common pathogens associated with corneal infection, particularly in contact lens-related keratitis events. The pathogenesis of P...
  94. ncbi Two cases of pneumococcal keratitis following myopic LASIK
    Tova Lifshitz
    Department of Ophthalmology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Refract Surg 21:498-501. 2005
    To report two cases of pneumococcal keratitis after LASIK.
  95. ncbi Keratitis after implantation of intrastromal corneal ring segments
    Raneen Shehadeh-Masha'our
    Department of Ophthalmology, Bnai Zion Medical Center Rappaport Faculty of Medicine Technion, Golomb Street 47, Haifa, Israel
    J Cataract Refract Surg 30:1802-4. 2004
    ..This progressed to a lower channel infection followed by diffuse keratitis. Culture from the conjunctiva was positive for Staphylococcus epidermidis, but cultures from the cornea were ..
  96. ncbi The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection
    X Jin
    Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, People s Republic of China
    Eur J Clin Microbiol Infect Dis 29:231-8. 2010
    b>Keratitis caused by Pseudomonas aeruginosa is a potentially vision-threatening condition that requires prompt treatment to prevent vision loss...
  97. ncbi A Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice
    Emma B H Hume
    The School of Optometry and Vision Science, The University of New South Wales, Australia
    Immunol Cell Biol 83:294-300. 2005
    Staphylococcus is a leading cause of the potentially blinding disease microbial keratitis. Even with the use of antibiotic therapy, the host inflammatory response continues to damage the cornea, which may lead to blindness...
  98. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  99. ncbi Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits
    Yusuf Onlen
    Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Mustafa Kemal University, Antakya Hatay, Turkey
    Microbiol Res 162:62-8. 2007
    ..out whether propolis could be an alternative or an adjunctive treatment, in experimental Pseudomonas aeruginosa keratitis. Intrastromal P. aeruginosa strains were given to both eyes of 20 young New Zealand white rabbits...
  100. ncbi A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad
    Jay R Montgomery
    USN, National Naval Medical Center, Bethesda, Maryland 20889, USA
    J Am Acad Dermatol 51:377-82. 2004
    ..deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome...
  101. pmc Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis
    Joseph J Dajcs
    Department of Microbiology, Immunology, and Parasitology, LSU Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Antimicrob Agents Chemother 48:1948-52. 2004
    The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic ..

Research Grants70

  1. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..HSV-1 is one of the most common viral infections affecting humans from mild cold sores to severe ocular keratitis and deadly encephalitis...
  2. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..Herpes simplex virus type-1 (HSV-1) lytic infection causes diseases ranging from simple cold sores to dangerous keratitis and lethal encephalitis...
  3. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..and can result in blindness, and most common manifestations of ocular infections affect the cornea, resulting in keratitis. Fungal keratitis is predominantly caused by filamentous fungi Fusarium, but yeasts (e.g...
  4. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..chemical burns, chronic contact lens hypoxia, Stevens-Johnson syndrome, pterygia, graft rejection and infectious keratitis (2-4)...
  5. Mechanisms to restrain social cheating from quorum sensing in Pseudomonas aerugin
    AJAI DANDEKAR; Fiscal Year: 2013
    ..It also causes difficult-to-treat burn and diabetic wound infections, keratitis, and ventilator-associated pneumonia. P...
  6. Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis
    K P CONNIE TAM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis Corneal infection is a major cause of visual impairment and blindness in both adults and children worldwide...
  7. MOLECULAR REGULATION OF CORNEAL WOUND HEALING
    Fu Shin X Yu; Fiscal Year: 2013
    ..in sight threatening complications, such as persistent epithelial defect, recurrent erosion, and microbial keratitis. Preliminary studies using streptozotocin (SZT)-treated rats as a type 1 diabetes model and human diseased ..
  8. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2013
    Project Summary/Abstract Herpes simplex virus (HSV) keratitis is a leading cause of non-traumatic blindness in developed countries, with more than 400,000 cases in the USA, with approximately 50,000 new and recurring cases per year...
  9. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    Microbial keratitis is a common cause of vision loss. The cornea is exquisitely sensitive to inflammation- mediated damage and therefore has strong innate defenses...
  10. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    ..pDC are the major source of IFN-a in the cornea and play a protective role in the host defense in herpes simplex keratitis (HSK)...
  11. CAP37 and ocular inflammation
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..in ocular infection we will use CAP37 and its bioactive peptides in a murine model of Pseudomonas aeruginosa keratitis to determine in vivo efficacy...
  12. CYTOTOXIC LYMPHOCYTES AND HSV-1 CORNEAL LESIONS
    Robert L Hendricks; Fiscal Year: 2013
    ..in sensory neurons and anterograde transport to the cornea appears to be a predominant cause of recurrent herpes keratitis, a blinding disease of the cornea...
  13. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    Recurrent herpes stromal keratitis (HSK) remains the major cause of infectious blinding disease in the US, with the only effective treatment being corneal transplantation...
  14. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..Our innovative approach will define potential agents for neurotrophic keratitis and dry eye after refractive surgery and HSV-1 infection.
  15. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial keratitis is a costly and global problem that results in vision loss and blindness, and Serratia marcescens is a leading agent of community-acquired Gram-negative bacterial keratitis. S...
  16. Mechanisms of IVIG Protection in Viral Encephalitis
    EDOUARD M CANTIN; Fiscal Year: 2010
    ..far suggest IVIG will be useful for treating HSE and other immune mediated HSV diseases such as herpes stromal keratitis (HSK)...
  17. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    ..response found in the draining lymph node reflected by the severity in the development of herpetic stromal keratitis of HSV-1 infected mice...
  18. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2011
    Herpes simplex virus (HSV) infections are responsible for recurrent corneal herpetic keratitis, as well as sporatic acute encephalitis...
  19. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..Therefore, this study proposes to use an in vivo mouse ocular model of herpetic stromal keratitis (HSK) to assess the efficacy of these peptides...
  20. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..N-65 lacritin can reduce established Pseudomonas aeruginosa and/or Staphylococcus aureus infections in a rabbit keratitis model. 2. A demonstration that N-65 lacritin can serve as an antimicrobial preservative in topical eye drops...
  21. New Therapies for Pathogenic Free-Living Amoebae
    Dennis E Kyle; Fiscal Year: 2013
    ..Acanthamoeba spp. also causes amoebic keratitis, skin, nasopharyngeal, and disseminated infections...
  22. Herpes Simplex Virus Egress from Cells and Spread into Neuronal Axons
    David C Johnson; Fiscal Year: 2013
    ..in the corneal stroma, normally an immunoprivileged tissue, producing a disease known as herpes stromal keratitis (HSK)...
  23. Corneal Expression and Function of Slurp1
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013
    ..More importantly, (a) over-expression of Slurp1 hindered the neutrophil influx in adenoviral keratitis and (b) Slurp1 bound the uPAR ligand uPA, suggesting that Slurp1 inhibits inflammation by competitive binding of ..
  24. Bacteria-Mucin Interactions at the Ocular Surface
    Ilene K Gipson; Fiscal Year: 2012
    ..Examples of the first are Staphylococcus aureus (SA) or Streptococcus pneumoniae (SPE) (encapsulated) keratitis that occurs as the result of epithelial surface damage from trauma. Other types of infection, e.g...
  25. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS K VERSELIS; Fiscal Year: 2013
    ..of deafness in which sensorineural hearing loss is accompanied by severe, inflammatory skin disorders, such as keratitis-ichthiosis-deafness (KID) syndrome...
  26. ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSID
    Jay C Brown; Fiscal Year: 2012
    ..disseminated illness in the newborn, cold sores, genital lesions, non-epidemic encephalitis in adults, a stromal keratitis and retinitis...
  27. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..leads to extensive dendrite formation followed by cell damage which mimics the dendrites of herpetic stromal keratitis (HSK) reported in human cornea infected with HSV-1...
  28. Cx26 mutations in syndromic deafness linked to skin disease
    Thomas W White; Fiscal Year: 2013
    ..or syndromic deafness associated with a variety of skin disorders including palmoplantar keratoderma (PPK), keratitis- ichthyosis-deafness syndrome (KID), and Vohwinkel syndrome (VS)...
  29. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
    ..retinopathy of prematurity, and glaucoma, corneal neovascularization associated with conditions such as Herpetic Keratitis, Trachoma, burns, and revascularization of corneal transplants, and other angiogenesis-dependant diseases such ..
  30. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2013
    ..of virus in tears leading to spread of virus to other individuals, and can also cause recurrent Herpes Stromal Keratitis (HSK), a blinding ocular disease...
  31. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013
    Abstract: Acanthamoeba keratitis (AK) is a serious, debilitating, and intensely painful infection of the cornea caused by parasites of the genus Acanthamoeba...
  32. HSV-1 LAT miRNAs: Neurovirulence, reactivation, mechanism
    Steven L Wechsler; Fiscal Year: 2013
    ..from latency in the trigeminal ganglia (TG) can cause herpes simplex encephalitis (HSE) and herpes stromal keratitis (HSK). HSE is the most common cause of sporadic lethal encephalitis in immune competent individuals...
  33. Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial Infection
    Darlene A Dartt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial conjunctivitis and keratitis occur in approximately 25,000 Americans annually with Staphylococcus aureus (S. aureus) being the leading cause of infection...
  34. CORNEAL EPITHELIAL STEM CELLS
    Robert M Lavker; Fiscal Year: 2013
    ..biology but to disorders of corneal epithelial differentiation, particularly:(i) dystrophies;(ii) dry eye;(iii) keratitis resulting from excessive glycogen depletion;and (iv) diabetic-induced keratopathies...
  35. Planning Grant for Parasitic Ulcer Treatment Trial
    Jeremy David Keenan; Fiscal Year: 2013
    ..of this study is to plan for a clinical trial to determine better ways to diagnose and treat acanthamoeba keratitis. Acanthamoeba keratitis is a blinding corneal infection that is an increasingly common cause of visual ..
  36. Diversity and Dynamic Stability of the Ocular Surface Microbiome
    Russell N Van Gelder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ocular infectious diseases, including microbial keratitis, conjunctivitis, and endophthalmitis, remain a significant cause of potentially blinding disease...
  37. Functions of mammalian PGLYRPs in the cornea
    Shukti Chakravarti; Fiscal Year: 2012
    ..1) Test antibacterial defense capabilities of Pglyrp1-4 null mice in a Pseudomonas (P).aeruginosa keratitis model...
  38. The Role of IL-17 in fungal keratitis
    PATRICIA RENEE TAYLOR; Fiscal Year: 2013
    ..In the proposed experiments I will determine the relative contribution of Th17 cells and IL-17 producing cells in protective immunity in fungal keratitis. )
  39. Lipid Rafts in Adenoviral Ocular Pathogenesis
    Jaya Rajaiya; Fiscal Year: 2013
    ..The clinical manifestations of this infection include severe pseudomembranous conjunctivitis and epithelial keratitis, followed by multifocal subepithelial (stromal) corneal infiltrates that cause photophobia and reduced vision ..
  40. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
    Summary Acanthamoeba keratitis is a sight-threatening corneal disease caused by pathogenic free-living amoebae...
  41. Ocular HSV-Latency, Reactivation, and Recurrence
    James M Hill; Fiscal Year: 2012
    ..In the USA, 300,000 cases are treated yearly. Ocular HSV causes a self-limiting epithelial keratitis, blepharitis, con- junctivitis, stromal keratitis, and the most damaging disease, necrotizing herpetic stromal ..
  42. Identifying mechanisms of translocation of epithelial cells by P. aeruginosa.
    DANIELLE KRISTY AUGUSTIN; Fiscal Year: 2010
    Pseudomonas aeruginosa keratitis is a sight-threatening complication of contact lens wear...
  43. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..In diseases of mucin deficiency such as anesthetic cornea, herpetic keratitis, and neurotrophic keratitis, as well as in aging and LASIK surgery, activation of neural and growth factor ..
  44. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
    ..aeruginosa) is a Gram-negative, opportunistic pathogen associated with bacterial keratitis, especially in contact lens usage...
  45. REPRESSION AND ACTIVATION OF PERSISTING HSV GENOMES
    Neal A DeLuca; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex virus infections can result in recurrent sores, stromal keratitis leading to blindness, or encephalitis...
  46. Mechanisms of Herpetic Keratitis
    Barry T Rouse; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Keratitis caused by herpes simplex virus (HSV) infection remains a troublesome ocular disease that can result in blindness...
  47. Corneal neuropeptides and herpetic stromal keratitis
    Susmit Suvas; Fiscal Year: 2013
    ..provided by applicant): Corneal infection with herpes simplex virus-1 (HSV-1) causes herpetic stromal keratitis (HSK), a leading cause of infection-induced corneal blindness worldwide...
  48. Role of DNA damage in the early steps of HSV infection and latency in neurons
    Matthew D Weitzman; Fiscal Year: 2013
    ..1 (HSV-1) is a human DNA virus that causes a number of diseases involving the human nervous system, including keratitis and encephalitis...
  49. T regulatory Cells in HSV Immunity and Immunopathology
    Barry T Rouse; Fiscal Year: 2013
    ..The disease is referred as to as stromal keratitis (SK)...
  50. TRANSPLANT AND TUMOR REJECTION PROCESSES WITHIN THE EYE
    Jerry Niederkorn; Fiscal Year: 2013
    ..It is noteworthy that three major causes of infectious blindness - trachoma, river blindness, and HSV keratitis - are immune-mediated diseases and represent loss of ocular immune privilege...
  51. Alpha-Herpesvirus Transport on Axons
    Gregory Allan Smith; Fiscal Year: 2013
    ..causative agents of a number of severe diseases including shingles, encephalitis, neonatal infections and herpes keratitis (the leading cause of infectious blindness in the USA and other industrialized nations)...
  52. Myocotic Ulcer Treatment Trial
    Thomas M Lietman; Fiscal Year: 2013
    We propose to evaluate which topical agent, voriconazole or natamycin, is the superior treatment for fungal keratitis in a randomized, masked, controlled trial...
  53. Immunopathogenesis of Adenovirus Keratitis
    James Chodosh; Fiscal Year: 2013
    ..The clinical manifestations of this infection include severe membranous conjunctivitis and epithelial keratitis, followed by multifocal subepithelial (stromal) corneal infiltrates that cause photophobia and reduced vision ..
  54. Staph keratitis: mechanism and arrest of ocular damage
    RICHARD JOSEPH O'CALLAGHAN; Fiscal Year: 2012
    ....
  55. HSPGs in Ocular Surface Diseases
    Pyong Woo Park; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Microbial keratitis is a sight-threatening infectious disease associated with significant ocular morbidity...
  56. Alpha-herpevirus assembly egress and viral particle heterogeneity
    Gregory Allan Smith; Fiscal Year: 2013
    ..Infections associated with high rates of morbidity or mortality includes encephalitis, keratitis, shingles and disseminated infections in newborns...
  57. The Role of Lumican in the cornea
    Shukti Chakravarti; Fiscal Year: 2012
    ..More importantly, in LPS-induced corneal keratitis, the Lum-/- mice show reduced neutrophil influx early, but overall delayed healing...
  58. MOLECULAR CHARACTERIZATION OF HERPES SIMPLEX VIRUS ICP27
    Stephen A Rice; Fiscal Year: 2013
    ..that causes several serious disesases including encephalitis, disseminated newborn infections, and stromal keratitis resulting in blindness...
  59. Virion Sialic Acid and HSV Ocular Infection
    Curtis R Brandt; Fiscal Year: 2011
    ..Several antivirals are currently approved for treating HSV keratitis but there are problems with their use and some infections are refractory to treatment...
  60. Role of Host Cell Factors in Herpes Simplex Virus (HSV) Keratitis
    RICHARD M LONGNECKER; Fiscal Year: 2012
    ..recurrent disease in the form of oral ulcers or more serious disease including encephalitis and herpes stromal keratitis (HSK)...
  61. The Pathogenesis of Aspergillus Keratitis
    SIXTO MANUEL LEAL; Fiscal Year: 2012
    ..This is especially true for filamentous fungal infections of the cornea (i.e keratitis), in which the majority of patients are fully immunocompetent...
  62. Toll like receptors in bacterial keratitis
    Eric Pearlman; Fiscal Year: 2012
    ..in relation to active bacterial infection, it is highly likely that this process is involved in sterile forms of keratitis associated with contact lens wear, including peripheral ulcer, red eye and corneal infiltrates...
  63. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..antimicrobial agents employed in the treatment of both bacterial and viral corneal stromal and epithelial keratitis. In this grant proposal we aim to characterize the ascorbate carrier systems expressed on the corneal membrane...
  64. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..on the mechanism(s) by which HSV infections induce corneal edema, the most common complication of herpetic keratitis. We propose that HSV-induced edema results from inhibition of corneal endothelial cell Na+K+ATPase by products ..
  65. Novel Corneal Implant Materials
    Shiao Chang; Fiscal Year: 2006
    ..and under-correction, regression, flap complications, glare, haloes, reduced night vision, diffuse lamellar keratitis, dry eye, and inability to correct predictably large hyperopic and myopic refractive errors...
  66. DNA Probes for Acanthamoeba Genomics and Epidemiology
    Paul Fuerst; Fiscal Year: 2007
    ..pathogenic protist Acanthamoeba, the causative agent of the sight-threatening disease Acanthamoeba keratitis (AK)...
  67. IONTOPHORESIS OF ANTIVIRALS TO HERPES EYE INFECTIONS
    James Hill; Fiscal Year: 1980
    ..HSV uveitis and stromal keratitis. HSV uveitis and stromal keratitis are examples of eye infections occurring beyond the corneal epithelium that ..
  68. ONCHOCERCIASIS: IMMUNE-MEDIATED EYE DISEASE
    Bulbul Chakravarti; Fiscal Year: 1992
    The broad, long-term objectives are to elucidate the pathogenesis of onchocercal sclerosing keratitis and to identify antigens that may lead to disease in infected humans...
  69. IDENTIFY LIMBAL STEM CELLS BY CELL SURFACE MARKERS
    Ronald Smith; Fiscal Year: 2005
    ..aniridia, pterygium, herpes simplex epithelial disease contact lens induced keratopathy, neuroparalytic keratitis, drug toxicity, or multiple surgical procedures in the corneolim region and may lead to loss of limbal stem ..
  70. Biofilm Formation And P. aeruginosa infection of the eye
    Michael Zegans; Fiscal Year: 2006
    ..Pseudomonas aeruginosa (PA) is one of the most common causes of bacterial keratitis. The central hypothesis of this proposal is that biofilm formation plays an important role in the pathogenesis ..