pterygium

Summary

Summary: An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)

Top Publications

  1. ncbi Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study
    A Fotouhi
    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Eye (Lond) 23:1125-9. 2009
  2. ncbi Acute scleral thinning after pterygium excision with intraoperative mitomycin C: a case report of scleral dellen after bare sclera technique and review of the literature
    Yi Yu Tsai
    Department of Ophthalmology, China Medical College Hospital, Taichung, Taiwan
    Cornea 21:227-9. 2002
  3. ncbi The results of amniotic membrane transplantation for primary pterygium compared with conjunctival autograft
    Napaporn Tananuvat
    Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand
    Cornea 23:458-63. 2004
  4. ncbi Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1
    M Aspiotis
    Department of Ophthalmology, University of Ioannina, Ioannina, Epirus, Greece
    Eye (Lond) 21:1095-101. 2007
  5. ncbi Pathogenetic mechanisms and treatment options for ophthalmic pterygium: trends and perspectives (Review)
    Efstathios T Detorakis
    Department of Ophthalmology, University Hospital of Heraklion, and Laboratory of Virology, Medical School, University of Crete, 71110 Heraklion, Crete, Greece
    Int J Mol Med 23:439-47. 2009
  6. ncbi Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study
    A Karalezli
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Br J Ophthalmol 92:1206-10. 2008
  7. ncbi Oxidative stress in pterygium: relationship between p53 and 8-hydroxydeoxyguanosine
    Maria Teresa Perra
    Department of Cytomorphology, University of Cagliari, Monserrato, Italy
    Mol Vis 12:1136-42. 2006
  8. pmc Ophthalmic pterygium: a stem cell disorder with premalignant features
    Jeanie Chui
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Pathol 178:817-27. 2011
  9. ncbi Pterygium: prevalence, demography and risk factors
    S M Saw
    National University of Singapore Department of Community, Occupational and Family Medicine Singapore
    Ophthalmic Epidemiol 6:219-28. 1999
  10. ncbi Prevalence and risk factors of pterygium in a southwestern island of Japan: the Kumejima Study
    Hiroki Shiroma
    Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan
    Am J Ophthalmol 148:766-771.e1. 2009

Detail Information

Publications302 found, 100 shown here

  1. ncbi Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study
    A Fotouhi
    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Eye (Lond) 23:1125-9. 2009
    To determine the prevalence and causes of pterygium and pinguecula in the population of Tehran in 2002.
  2. ncbi Acute scleral thinning after pterygium excision with intraoperative mitomycin C: a case report of scleral dellen after bare sclera technique and review of the literature
    Yi Yu Tsai
    Department of Ophthalmology, China Medical College Hospital, Taichung, Taiwan
    Cornea 21:227-9. 2002
    To describe a patient with scleral dellen after pterygium excision with intraoperative mitomycin C.
  3. ncbi The results of amniotic membrane transplantation for primary pterygium compared with conjunctival autograft
    Napaporn Tananuvat
    Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand
    Cornea 23:458-63. 2004
    To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and to compare the clinical outcome with that of conjunctival autograft.
  4. ncbi Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1
    M Aspiotis
    Department of Ophthalmology, University of Ioannina, Ioannina, Epirus, Greece
    Eye (Lond) 21:1095-101. 2007
    This retrospective study aims to elucidate the role of angiogenesis in the pathogenesis of pterygium. We evaluated microvessel density (MVD), and expression of vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1).
  5. ncbi Pathogenetic mechanisms and treatment options for ophthalmic pterygium: trends and perspectives (Review)
    Efstathios T Detorakis
    Department of Ophthalmology, University Hospital of Heraklion, and Laboratory of Virology, Medical School, University of Crete, 71110 Heraklion, Crete, Greece
    Int J Mol Med 23:439-47. 2009
    b>Pterygium is a fibrovascular lesion of the ocular surface that can display an aggressive clinical behavior and, occasionally, threaten vision...
  6. ncbi Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study
    A Karalezli
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Br J Ophthalmol 92:1206-10. 2008
    To compare the use of fibrin glue versus sutures for fixating conjunctival autografts in patients undergoing pterygium excision.
  7. ncbi Oxidative stress in pterygium: relationship between p53 and 8-hydroxydeoxyguanosine
    Maria Teresa Perra
    Department of Cytomorphology, University of Cagliari, Monserrato, Italy
    Mol Vis 12:1136-42. 2006
    ..is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium, a benign invasive lesion of the bulbar conjunctiva...
  8. pmc Ophthalmic pterygium: a stem cell disorder with premalignant features
    Jeanie Chui
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Pathol 178:817-27. 2011
    ..One hundred pterygium specimens were histopathologically reviewed and selected cases were immunohistochemically assessed to confirm ..
  9. ncbi Pterygium: prevalence, demography and risk factors
    S M Saw
    National University of Singapore Department of Community, Occupational and Family Medicine Singapore
    Ophthalmic Epidemiol 6:219-28. 1999
    b>Pterygium is not just a degenerative disease, but may be a proliferative disorder of the ocular surface. The etiology of pterygia has intrigued researchers for centuries...
  10. ncbi Prevalence and risk factors of pterygium in a southwestern island of Japan: the Kumejima Study
    Hiroki Shiroma
    Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan
    Am J Ophthalmol 148:766-771.e1. 2009
    To determine the prevalence and risk factors for pterygium in a Japanese population aged 40 years or older on Kumejima Island, Japan.
  11. ncbi The roles of T-lymphocyte subpopulations (CD4 and CD8), intercellular adhesion molecule-1 (ICAM-1), HLA-DR receptor, and mast cells in etiopathogenesis of pterygium
    Umit Beden
    Ophthalmology Department, Kars State Hospital, Kars, Turkey
    Ocul Immunol Inflamm 11:115-22. 2003
    ..We wished to explore the effects of inflammatory cells and mediators such as T-lymphocyte subpopulations (CD4 and CD8), mast cells, intercellular adhesion molecule-1 (ICAM-1), and HLA-DR receptors on pterygium development.
  12. ncbi The prevalence and risk factors for pterygium in an adult Chinese population in Singapore: the Tanjong Pagar survey
    T Y Wong
    Singapore National Eye Centre and Eye Research Institute, 11 Third Hospital Ave, Singapore 168751, Singapore
    Am J Ophthalmol 131:176-83. 2001
    PURPOSE: To determine the prevalence and risk factors for pterygium in the Chinese population of Singapore...
  13. ncbi Epidemiology of pterygium in aged rural population of Beijing, China
    Qing feng Liang
    Beijing Institute of Ophthalmology Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
    Chin Med J (Engl) 123:1699-701. 2010
    b>Pterygium is a common ophthalmic disease and an important public health problem. It may be affected by many factors such as age, gender, ultraviolet radiation exposure, and time spent outdoors...
  14. ncbi UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells
    Nick Di Girolamo
    Inflammation Research Unit, School of Medical Sciences, Department of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 43:3430-7. 2002
    ..The hypothesis tested in the current study is that UV radiation modulates the expression of interleukin (IL)-6 and -8, which could promote the neovascularization and chronic inflammation regularly observed in pterygia...
  15. ncbi Intraoperative daunorubicin versus conjunctival autograft in primary pterygium surgery
    Subhash Dadeya
    Department of Ophthalmology, Safdarjung Hospital, New Delhi, India
    Cornea 21:766-9. 2002
    To evaluate the safety and efficacy of intraoperative daunorubicin during a bare sclera procedure in primary pterygium surgery and to compare with conjunctival autograft.
  16. ncbi Prevalence of and racial differences in pterygium: a multiethnic population study in Asians
    Marcus Ang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Ophthalmology 119:1509-15. 2012
    To describe the prevalence and risk factors of pterygium in a multiethnic Asian population and to examine racial differences.
  17. ncbi Prevalence of pterygium in Latinos: Proyecto VER
    S West
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    Br J Ophthalmol 93:1287-90. 2009
    b>Pterygium is a common corneal eye condition that can be disfiguring and may require surgery to avoid loss of vision. There are no population-based data on the prevalence or on risk factors among Latinos.
  18. ncbi Pterygium in an aged Mongolian population: a population-based study in China
    J Lu
    Institute of Developmental Biology, Lanzhou University, China
    Eye (Lond) 23:421-7. 2009
    To determine the prevalence and identify associated risk factors for pterygium in an elderly Mongolian population at high altitude in Henan County, China.
  19. ncbi The prevalence of and risk factors for pterygium in an urban Malay population: the Singapore Malay Eye Study (SiMES)
    H Cajucom-Uy
    Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore
    Br J Ophthalmol 94:977-81. 2010
    To determine the prevalence and risk factors for pterygium in the adult Malay population of Singapore.
  20. ncbi Quantitative analysis of regular and irregular astigmatism induced by pterygium
    A Tomidokoro
    Department of Ophthalmology, Omiya Red Cross Hospital, Saitama, Japan
    Cornea 18:412-5. 1999
    To quantitatively evaluate the influence of pterygium and its removal surgery on both regular and irregular corneal astigmatism.
  21. ncbi The science of pterygia
    J C Bradley
    Department of Ophthalmology and Vision Sciences, University of California Davis, Sacramento, California, USA
    Br J Ophthalmol 94:815-20. 2010
    b>Pterygium is an ocular surface disease of humans attributed to chronic ultraviolet-B exposure. Clinically, the condition involves invasive centripetal growth with associated inflammation and neovascularisation...
  22. ncbi Increased oxidative DNA damage, 8-hydroxydeoxy- guanosine, in human pterygium
    H C Kau
    Department of Ophthalmology, Taoyuan Veterans Hospital, Taoyuan, Taiwan
    Eye (Lond) 20:826-31. 2006
    Chronic exposure to ultraviolet (UV) light is a widely accepted aetiological factor in the development of pterygium. UV radiation may induce production of reactive oxygen species via photosensitized oxidation, thus causing oxidative ..
  23. ncbi Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head
    N Di Girolamo
    Inflammation Research Unit, School of Pathology, University of New South Wales, Australia
    Invest Ophthalmol Vis Sci 41:4142-9. 2000
    ..The purpose of this study was to determine the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) at the advancing pterygium edge.
  24. ncbi Active matrilysin (MMP-7) in human pterygia: potential role in angiogenesis
    N Di Girolamo
    Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 42:1963-8. 2001
    ..The purpose of this study was to determine the cellular distribution and activation status of matrilysin (MMP-7) in pterygia...
  25. ncbi Angiogenesis in pterygium: morphometric and immunohistochemical study
    Arie L Marcovich
    Department of Ophthalmology, Kaplan Medical Center, Rehovot, Israel
    Curr Eye Res 25:17-22. 2002
    To evaluate the role of angiogenesis in the pathogenesis of pterygium by comparing the expression of von-Willebrand factor (vWF) and vascular endothelial growth factor (VEGF) in pterygium, and in normal superior bulbar conjunctiva.
  26. ncbi Effect of TIMP-1 and MMP in pterygium invasion
    Yi Yu Tsai
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Invest Ophthalmol Vis Sci 51:3462-7. 2010
    ..Therefore, the purpose of this study was to determine the role of MMP-9, MMP-10, and TIMPs in pterygium formation and progression. METHODS...
  27. ncbi Current concepts and techniques in pterygium treatment
    Leonard P K Ang
    Singapore National Eye Centre, Singapore
    Curr Opin Ophthalmol 18:308-13. 2007
    b>Pterygium is a common ocular disorder in many parts of the world. At present, there is a wide variety of surgical methods but very few clinical guidelines on the optimal treatment of primary or recurrent pterygium...
  28. ncbi Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Curr Eye Res 33:23-8. 2008
    ..We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia...
  29. ncbi Oxidative DNA damage in pterygium
    Yi Yu Tsai
    Department of Ophthalmology, China Medical University Hospital and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 11:71-5. 2005
    ..If pterygium is related to UV, we surmised oxidative stress exists in pterygium...
  30. ncbi In vivo confocal microscopic evaluation of morphologic changes and dendritic cell distribution in pterygium
    Yan Wang
    Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
    Am J Ophthalmol 150:650-655.e1. 2010
    To observe morphologic changes and the distribution of dendritic cells in pterygium using in vivo laser scanning confocal microscopy (LSCM).
  31. pmc Prevalence of pinguecula and pterygium in a general population in Spain
    E Viso
    Department of Ophthalmology, Complexo Hospitalario de Pontevedra, Pontevedra, Spain
    Eye (Lond) 25:350-7. 2011
    To determine the prevalence of pinguecula and pterygium and to investigate their associations in a general adult population in North-Western Spain.
  32. pmc Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium
    Satoru Kase
    Department of Ophthalmology, Sapporo Social Insurance General Hospital, Sapporo, Japan
    Br J Ophthalmol 91:958-61. 2007
    The pterygium is a growth onto the cornea of fibrovascular tissue that is continuous with the conjunctiva, whereas the mechanisms of cell proliferation in pterygium epithelium are unknown.
  33. ncbi Ocular surface disorder in pterygium: role of conjunctival impression cytology
    Ranjana Bandyopadhyay
    Department of Pathology, Medical College, Kolkata 700 073, India
    Indian J Pathol Microbiol 53:692-5. 2010
    To study ocular surface abnormalities in patients with pterygium, conjunctival impression cytology was explored as a tool for the assessment of the cytological changes.
  34. ncbi Recurrent pterygium surgery using pterygium extended removal followed by extended conjunctival transplant: recurrence rate and cosmesis
    Lawrence W Hirst
    University of Queensland and Queensland Eye Institute, Brisbane, Australia
    Ophthalmology 116:1278-86. 2009
    To assess the rate of recurrence, complications, and cosmesis after recurrent pterygium removal with P.E.R.F.E.C.T. for PTERYGIUM (Pterygium Extended Removal Followed by Extended Conjunctival Transplant).
  35. ncbi Growth factor expression in ophthalmic pterygia and normal conjunctiva
    Efstathios T Detorakis
    Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece
    Int J Mol Med 25:513-6. 2010
    The expression of growth factors in ophthalmic pterygium and phenotypically normal conjunctiva was examined and correlated with the clinical findings...
  36. ncbi Topical bevacizumab eyedrops for limbal-conjunctival neovascularization in impending recurrent pterygium
    Pei Chang Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Cornea 28:103-4. 2009
    To report a case of impending recurrent pterygium treated with topical bevacizumab eyedrops.
  37. ncbi Prevalence of and factors associated with pterygium in adult Chinese: the Beijing Eye Study
    Ke Ma
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Cornea 26:1184-6. 2007
    ..To evaluate the prevalence of pterygia and its associated factors in an adult Chinese population of Greater Beijing...
  38. pmc Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD
    Chun Chi Chiang
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Mol Vis 16:698-704. 2010
    b>Pterygium is an ultraviolet (UV) related disease. UV radiation can produce DNA damage, which is repaired by the DNA repair systems...
  39. ncbi The presence of T-lymphocyte subpopulations (CD4 and CD8) in pterygia: evaluation of the inflammatory response
    Richard M Awdeh
    Department of Ophthalmology, Albert Eye Research Institute, Duke University Eye Center, Durham, NC 27710, USA
    Adv Ther 25:479-87. 2008
    The aim of our study was to confirm the presence of inflammatory T-lymphocyte subpopulations (CD4 and CD8) in pterygium specimens with regards to clinical severity...
  40. ncbi Recurrence rate using fibrin glue-assisted ipsilateral conjunctival autograft in pterygium surgery: 2-year follow-up
    Vincenzo Sarnicola
    Misericordia Hospital, Grosseto, Italy
    Cornea 29:1211-4. 2010
    To determine the recurrence rate after pterygium excision with ipsilateral conjunctival autograft using fibrin glue.
  41. ncbi Evaluation of conjunctival graft thickness after pterygium surgery by anterior segment optical coherence tomography
    Ahmad Kheirkhah
    Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Curr Eye Res 36:782-6. 2011
    To evaluate changes in thickness of the conjunctival graft after pterygium surgery by anterior segment optical coherence tomography (AS-OCT).
  42. ncbi Comparison of pterygium recurrence rates after limbal conjunctival autograft transplantation and other techniques: meta-analysis
    Kangkeng Zheng
    Joint Shantou International Eye Center, Shantou University, Shantou, China
    Cornea 31:1422-7. 2012
    Meta-analysis to compare pterygium surgery outcomes using limbal conjunctival autograft (LCAG) and other techniques.
  43. ncbi The prevalence of and risk factors associated with pterygium in a rural adult Chinese population: the Handan Eye Study
    Lan Ping Sun
    Handan Eye Hospital, Hebei Province, China
    Ophthalmic Epidemiol 20:148-54. 2013
    To describe the prevalence and risk factors for pterygium in a rural adult Chinese population.
  44. ncbi Prevalence of and risk factors for pterygium in rural adult chinese populations of the Bai nationality in Dali: the Yunnan Minority Eye Study
    Hua Zhong
    Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, People s Republic of China
    Invest Ophthalmol Vis Sci 53:6617-21. 2012
    The purpose of the study was to describe the prevalence, severity, and associated risk factors for pterygium in a population-based sample of rural residents of the Bai minority population in rural Dali, China.
  45. pmc Investigation of oxidative stress in pterygium tissue
    Mehmet Balci
    Department of Ophthalmology, Abdurrahman Yurtaslan Oncological Training and Research Hospital, Ankara, Turkey
    Mol Vis 17:443-7. 2011
    To investigate changes in the oxidant-antioxidant system in pterygium tissue.
  46. ncbi Prevalence and associated factors for pterygium in a rural adult population (the Southern Harbin Eye Study)
    Zhijian Li
    Department of Ophthalmology, First Affiliated Hospital, Harbin Medical University, Harbin, China
    Cornea 32:806-9. 2013
    To estimate the prevalence of pterygium and identify associated risk factors in a Southern Harbin population at low altitude in a cold climate.
  47. ncbi Immunohistochemical analysis of angiotensin converting enzyme in Sardinian pterygium
    Paolo Demurtas
    Department of Cytomorphology, University of Cagliari Medical School, Cagliari, Italy
    Histol Histopathol 28:759-66. 2013
    b>Pterygium is a common ocular surface disorder characterized by excessive cell proliferation, inflammation, fibrosis, angiogenesis and extracellular matrix remodeling...
  48. pmc Immunohistochemical detection of Hsp90 and Ki-67 in pterygium
    Roberto Sebastiá
    Department of Ophthalmology, Universitary Hospital Federal Fluminense University, Rio de Janeiro, Brazil
    Diagn Pathol 8:32. 2013
    To examine the immunohistochemical expression of heat shock protein 90 (Hsp90) and Ki-67 protein in human pterygium.
  49. ncbi Risk factors associated with pterygium and its subtypes in Korea: the Korean National Health and Nutrition Examination Survey 2008-2010
    Tyler Hyung Taek Rim
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    Cornea 32:962-70. 2013
    To assess the sociodemographic and health-related risk factors associated with pterygium and its subtypes in Korea.
  50. pmc Prevalence of pterygium in a population in Northern Japan: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study
    Takatoshi Tano
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Acta Ophthalmol 91:e232-6. 2013
    The aim of the study was to determine the prevalence and risk factors for pterygium in a population aged 40-74 years in Fukushima Prefecture, Japan.
  51. ncbi Overexpression of peroxiredoxin 2 in pterygium. A proteomic approach
    V M Bautista-de Lucio
    Microbiology and Ocular Proteomics, Research Unit, Institute of Ophthalmology Fundación de Asistencia Privada Conde de Valenciana, Chimalpopoca, 14 Colonia Obrera, 06800 Mexico City, Mexico
    Exp Eye Res 110:70-5. 2013
    b>Pterygium is one of the most frequent pathologies in ophthalmology, and is a benign, fibrovascular lesion originating from the bulbar conjunctiva...
  52. ncbi Comparison of conjunctival autograft with amniotic membrane transplantation for pterygium surgery: surgical and cosmetic outcome
    Cem Kucukerdonmez
    Baskent University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey
    Cornea 26:407-13. 2007
    ..clinical results of conjunctival autograft and amniotic membrane transplantation (AMT) for primary and recurrent pterygium excision...
  53. ncbi Comparison of fibrin glue versus suture for conjunctival autografting in pterygium surgery: a meta-analysis
    Hong wei Pan
    Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, China
    Ophthalmology 118:1049-54. 2011
    To evaluate the safety and clinical efficacy of fibrin glue in pterygium surgery with conjunctival autografting.
  54. ncbi Pterygium in Tibetans: a population-based study in China
    Peng Lu
    Ophthalmology Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Clin Experiment Ophthalmol 35:828-33. 2007
    To describe the prevalence and to identify associated risk factors for pterygium in a Tibetan population at high altitude in Zeku County, China.
  55. ncbi Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium
    Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 110:119-24. 2003
    To study the effect of amniotic membrane transplantation (AMT) combined with either limbal autograft transplantation (LAT) or conjunctival autograft transplantation (CAT) in recurrent pterygium.
  56. ncbi Efficacy of topical bevacizumab for inhibiting growth of impending recurrent pterygium
    Mohammad Reza Fallah
    Department of Ophthalmology, School of Medicine, Medical Sciences, Tehran University, Tehran, Iran
    Curr Eye Res 35:17-22. 2010
    To evaluate clinical outcome(s) and complication(s) of topical bevacizumab (avastin) in patients with impending recurrent pterygium.
  57. ncbi Phase I study of subconjunctival ranibizumab in patients with primary pterygium undergoing pterygium surgery
    Anat Galor
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 149:926-931.e2. 2010
    To evaluate the safety and tolerability of ranibizumab given via subconjunctival injection in patients with primary pterygium undergoing pterygium surgery with autograft placement.
  58. ncbi Preliminary results of subconjunctival bevacizumab in primary pterygium excision
    Mohammad Reza Razeghinejad
    Department of Ophthalmology and Poostchi Ophthalmic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    Ophthalmic Res 43:134-8. 2010
    To evaluate the efficacy of subconjunctival bevacizumab as an adjunctive therapy for primary pterygium surgery.
  59. ncbi Subconjunctival bevacizumab immediately after excision of primary pterygium: the first clinical trial
    Abdollah Shenasi
    Department of Ophthalmology, Nikookari Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    Cornea 30:1219-22. 2011
    To investigate the effect of subconjunctival bevacizumab immediately after excision of primary pterygium.
  60. ncbi Treatment of pterygium
    Isyaku Mohammed
    Department of Ophthalmology, Aminu Kano Teaching Hospital, Kano, Nigeria
    Ann Afr Med 10:197-203. 2011
    The treatment of ocular pterygium has been subjected to the development and application of various new strategies in the last few years...
  61. ncbi Corneo-conjunctival autograft transplantation for pterygium surgery
    Eric Frau
    Institute Gustave Roussy, Villejuif, France
    Acta Ophthalmol Scand 82:59-63. 2004
    To evaluate the efficacy of surgical management of pterygium with corneo-conjunctival autograft transplantation.
  62. ncbi The Ets-1 transcription factor is involved in pterygial angiogenesis
    W Naib-Majani
    Department of International Medical Education and Development, Bonn, Germany
    Anat Histol Embryol 36:107-10. 2007
    ..In contrast, no expression of ets-1 was found in group 2 pterygia. Proto-oncogene ets-1 expression has been shown for the first time in the metaplastic pterygium, an eye tissue of unknown pathogenesis.
  63. ncbi Analysis of pathohistological characteristics of pterygium
    Boban Dzunic
    Ophthalmology Clinic, Clinical Center, Nis, Serbia
    Bosn J Basic Med Sci 10:307-13. 2010
    b>Pterygium internum (external eye layer) shows great recurrence tendency after surgical removal. Its etiology is still unclear and represents a significant problem...
  64. ncbi A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival autografts and histologic evaluation after pterygium excision
    Yasemin Ozdamar
    Ankara Ulucanlar Eye Research Hospital, Ankara, Turkey
    Cornea 27:552-8. 2008
    To compare clinical and histopathologic outcomes of tissue glue and vicryl suture to attach limbal conjunctival autografts in pterygium surgery.
  65. pmc Serious corneoscleral complications after pterygium excision with mitomycin C
    B Safianik
    Br J Ophthalmol 86:357-8. 2002
  66. ncbi Bevacizumab and ocular wound healing after primary pterygium excision
    Mohammad Banifatemi
    Department of Ophthalmology, Shiraz University of Medical Sciences, Khalili Hospital, Shiraz, Iran
    J Ocul Pharmacol Ther 27:17-21. 2011
    The aim of this study was to evaluate the effect of subconjunctival bevacizumab on early postoperative wound healing in patients with primary pterygium excision.
  67. ncbi Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial
    S Srinivasan
    Department of Ophthalmology, Toronto Western Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Ophthalmol 93:215-8. 2009
    To compare the degree of conjunctival autograft inflammation, subconjunctival haemorrhage (SCH) and graft stability following the use of sutures or fibrin glue (FG) during pterygium surgery.
  68. ncbi Scleral melting 16 years after pterygium excision with topical Mitomycin C adjuvant therapy
    W M Wan Norliza
    Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Cont Lens Anterior Eye 29:165-7. 2006
    To report a case of scleral melting noted 16 years after pterygium excision with postoperative adjuvant topical Mitomycin C (MMC).
  69. ncbi Relationship between the morbidity of pterygium and the duration of ultraviolet rays exposure in Sanya, China
    Qi Chang Yan
    Department of Ophthalmology, Fourth Affiliated Hospital, China Medical University, Shenyang 110005, China
    Chin Med J (Engl) 119:1308-10. 2006
  70. ncbi Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium
    Anca Maria Cimpean
    Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Oncol Rep 26:1111-3. 2011
    Human pterygium is a benign fibrovascular outgrowth of the corneo-conjunctival junction, characterized by tissue remodeling, cellular proliferation, angiogenesis and inflammation...
  71. ncbi Low-dose intraoperative mitomycin C as chemoadjuvant for pterygium surgery
    H C Cheng
    Department of Ophthalmology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Cornea 20:24-9. 2001
    ..and safety of low-dose intraoperative mitomycin C (MMC) during bare sclera procedure and to compare the rates of pterygium recurrence between recurrent pterygium patients treated with adjuvant MMC and those reconstructed with a ..
  72. ncbi Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygia
    Ji Jin
    Department of Ophthalmology, The Jinhua Central Hospital, Zhejiang, China
    Cornea 22:473-7. 2003
    ..This study compared expression levels of an angiogenic inhibitor, pigment epithelium-derived factor (PEDF), in pterygia with those in normal corneal and conjunctival tissues...
  73. ncbi Pterygium: histological and immunohistochemical aspects
    T Golu
    Ophthalmology Clinic, Rovinari Hospital, Romania
    Rom J Morphol Embryol 52:153-8. 2011
    b>Pterygium represents a triangular conjunctivo-epithelial overgrowth, proliferating from the bulbar conjunctiva and covering the cornea, causing severe vision loss...
  74. ncbi Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring
    Gysbert van Setten
    St Eriks Eye Clinic, Karolinska Institutet, Polhemsgatan 50, 11282 Stockholm, Sweden
    Graefes Arch Clin Exp Ophthalmol 241:135-9. 2003
    Various growth factors have been detected in pterygium and been associated with its vasculogenesis. The basic pathophysiological mechanisms responsible especially for the fibrotic activity in pterygium are, however, not yet known...
  75. ncbi [Expression of matrix metalloproteinase in human pterygia]
    Jun Zeng
    Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011, China
    Yan Ke Xue Bao 20:242-5. 2004
    To determine the cellular distribution and activation of MMP-2 and MMP-9 in human pterygium.
  76. pmc Calcium-binding S100 protein expression in pterygium
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Mol Vis 15:335-42. 2009
    b>Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea...
  77. ncbi Use of mitomycin C with conjunctival autograft in pterygium surgery in Asian-Canadians
    V A Wong
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Ophthalmology 106:1512-5. 1999
    ..To determine whether using mitomycin C (MMC) before applying conjunctival autograft is better than conjunctival autograft alone in preventing the recurrence of pterygia in an Asian-Canadian population...
  78. ncbi Elevation of human alpha-defensins and S100 calcium-binding proteins A8 and A9 in tear fluid of patients with pterygium
    Lei Zhou
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 50:2077-86. 2009
    ..In this study the authors determined that the inflammatory nature of pterygium is reflected in the protein components of tears.
  79. ncbi Endothelial progenitor cells in pterygium pathogenesis
    J K Lee
    Department of Ophthalmology, College of Medicine, Chung Ang University, Seoul, Korea
    Eye (Lond) 21:1186-93. 2007
    The pathogenesis of pterygium is not well known, and controversy exists about the cell origins and the nature of initial trigger required for its development...
  80. ncbi Pterygium in aged population in Doumen County, China
    Kaili Wu
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
    Yan Ke Xue Bao 18:181-4. 2002
    To estimate the prevalence of pterygium and its influence on visual acuity in aged population of Doumen County, southern China.
  81. pmc Pterygium in Indonesia: prevalence, severity and risk factors
    G Gazzard
    Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 139651
    Br J Ophthalmol 86:1341-6. 2002
    To determine prevalence rates, severity, and risk factors for pterygium in adults in provincial Indonesia and to validate a clinical grading scheme in a population based setting.
  82. ncbi Microbial scleritis-experience from a developing country
    V Jain
    LV Prasad Eye Institute, Hyderabad, India
    Eye (Lond) 23:255-61. 2009
    ..The purpose of this article was to study the clinical features, pathogenic organisms, and the outcome in cases of infectious scleritis...
  83. pmc Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration
    C J Jaworski
    Section on Molecular Therapeutics, NEI NIH, Bethesda, MD 20892, USA
    Mol Vis 15:2421-34. 2009
    b>Pterygium is a vision-impairing fibrovascular lesion that grows across the corneal surface and is associated with sunlight exposure...
  84. ncbi Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia
    A Solomon
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA
    Ophthalmology 108:449-60. 2001
    ..CONCLUSIONS: Amniotic membrane transplantation is an effective and safe procedure for pterygium surgery, with a relatively low recurrence rate for both primary and recurrent pterygia...
  85. ncbi The role of substance P in the pathogenesis of pterygia
    Jeanie Chui
    Inflammatory Diseases Research Unit, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:4482-9. 2007
    b>Pterygium is a prevalent ocular surface disorder thought to be triggered by chronic ultraviolet damage to the limbus...
  86. ncbi Prevalence of pterygium and cataract in indigenous populations of the Brazilian Amazon rain forest
    J S Paula
    School of Medicine of Ribeirao Preto, USP, Brazil
    Eye (Lond) 20:533-6. 2006
    To compare the prevalence of pterygium and cataract in four indigenous populations of the Brazilian Amazonian rain forest (Arawak, Tukano, Maku, and Yanomami) with different ethnic and social behaviour backgrounds.
  87. ncbi Photokeratitis and other phototoxic effects on the cornea and conjunctiva
    Anthony P Cullen
    School of Optometry and Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Int J Toxicol 21:455-64. 2002
    ..Chronic exposure to solar ultraviolet is a factor in climatic droplet keratopathy and pterygium. Phototoxic compounds or their by-products potentially can reach the cornea from the air, via the tears or ..
  88. ncbi Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts
    Timothy M Nolan
    Inflammation Research Unit, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 45:110-3. 2004
    ..and chemotactic effects of heparin binding epidermal growth factor-like growth factor (HB-EGF), recently shown to be upregulated by ultraviolet irradiation in pterygium-derived epithelium cells (PECs) and pterygium fibroblasts (PFs).
  89. ncbi A randomized controlled trial of intralesional bevacizumab injection on primary pterygium: preliminary results
    Orapin Enkvetchakul
    Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cornea 30:1213-8. 2011
    To evaluate the efficacy and safety of intralesional injection of bevacizumab on primary pterygium treatment.
  90. ncbi The effect of pterygium surgery on corneal topography
    A Cinal
    Yuzuncu Yil University Medical Faculty, Department of Ophthalmology, Van, Turkey
    Ophthalmic Surg Lasers 32:35-40. 2001
    The aim of this prospective randomized clinical study was to evaluate the effect of pterygium surgery on the corneal topography using a computerized corneal topography system.
  91. ncbi Visual acuity and corneal topographic changes related with pterygium surgery
    Meltem Yagmur
    Department of Ophthalmology, Cukurova University, Faculty of Medicine, Adana, Turkey
    J Refract Surg 21:166-70. 2005
    Applied pre- and postoperative corneal topography outcomes with visual acuities were evaluated to determine the surgical results in pterygium therapy.
  92. ncbi Scleral ulceration after preoperative injection of mitomycin C in the pterygium head
    Maria A Carrasco
    Cornea Service, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107, USA
    Arch Ophthalmol 120:1585-6. 2002
  93. ncbi The effect of subconjunctival ranibizumab on primary pterygium: a pilot study
    Achilleas Mandalos
    2nd Ophthalmology Clinic, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece
    Cornea 29:1373-9. 2010
    A prospective interventional pilot study was performed to estimate the effect of ranibizumab injection on the clinical and histological picture of primary pterygium.
  94. ncbi Comparison of fibrin glue with sutures for pterygium excision surgery with conjunctival autografts
    Reece C Hall
    Ophthalmology Department, Wellington Hospital, Capital Coast District Health Board, Wellington, New Zealand
    Clin Experiment Ophthalmol 37:584-9. 2009
    To compare pterygium excision conjunctival autograft surgery using Tisseel fibrin glue versus Vicryl sutures.
  95. ncbi Efficacy of intralesional bevacizumab injection in decreasing pterygium size
    Mohammad Reza Fallah Tafti
    Eye Research Center, Farabi Eye Hospital, Cornea Department, Tehran University of Medical Sciences, Tehran, Iran
    Cornea 30:127-9. 2011
    To evaluate the efficacy of intralesional bevacizumab injection in decreasing size of pterygium.
  96. pmc Progenitor cells in healing after pterygium excision
    Jeong Kyu Lee
    Department of Ophthalmology, College of Medicine, Chung Ang University, Yongsan gu, Seoul 140 757, Korea
    Yonsei Med J 48:48-54. 2007
    Bone marrow derived progenitor cells were reported to be involved in the pathogenesis of pterygium and have been suggested to be important in angiogenesis and the repair process after tissue damage...
  97. pmc Comments on using fibrin glue in pterygium surgery
    L S Alvarenga
    Br J Ophthalmol 89:392; author reply 392. 2005
  98. ncbi Postoperative irradiation for pterygium: retrospective analysis of 1,253 patients from the Osaka University Hospital
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Strahlenther Onkol 182:437-42. 2006
    Irradiation of ocular pterygium is considered a valuable treatment supplementation after surgical therapy...
  99. pmc Randomised controlled study of conjunctival autograft versus amniotic membrane graft in pterygium excision
    P Luanratanakorn
    Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Br J Ophthalmol 90:1476-80. 2006
    To determine whether amniotic membrane can be used as an alternative to conjunctival autograft after pterygium excision.
  100. ncbi Outcome of pterygium surgery: analysis over 14 years
    M Fernandes
    Cornea and Anterior Segment Service, LV Prasad Eye Institute, Hyderabad, India
    Eye (Lond) 19:1182-90. 2005
    To report the outcome of pterygium surgery performed at a tertiary eye care centre in South India.
  101. ncbi Long-term follow-up results of lamellar keratoplasty as a treatment for recurrent pterygium and for scleral necrosis induced by beta-irradiation
    Behrooz Golchin
    Sydney Hospital and Sydney Eye Hospital, Sydney, Australia
    Cornea 22:612-8. 2003
    To evaluate the efficacy and safety of lamellar keratoplasty (LK) in the treatment of recurrent pterygium and of scleral necrosis induced by beta-irradiation.

Research Grants12

  1. IDENTIFY LIMBAL STEM CELLS BY CELL SURFACE MARKERS
    Ronald Smith; Fiscal Year: 2005
    ..Stevens-Johnson syndrome, ocul cicatrIcial pemphigoid, contact lenses, severe infection, congenital aniridia, pterygium, herpes simplex epithelial disease contact lens induced keratopathy, neuroparalytic keratitis, drug toxicity, or ..
  2. PTERYGIUM EVALUATION PROJECT
    JOHN TWELKER; Fiscal Year: 2001
    ..Dr. Twelker observed, that many of his patients suffered from pterygium, a triangular growth of abnormal tissue which grows from the conjunctiva onto the cornea, often causing blurred ..
  3. Modular Design Biotherapeutics to Treat Eye and Cornea
    Michael Burg; Fiscal Year: 2005
    ..Our model proliferative disease is pterygium. In pterygium, corneal cells grow in response to endogenous EGF ligands and obscures vision...
  4. AMD AND RISK FACTORS IN A HISPANIC POPULATION
    Sheila West; Fiscal Year: 2003
    ..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
  5. TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASIS
    Sheila West; Fiscal Year: 2005
    ..abstract_text> ..
  6. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
  7. Cataract: Health Disparity for Older African-Americans
    Sheila West; Fiscal Year: 2006
    ..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
  8. Latino Eye Health: A Communication Strategy for Diabetes
    Sheila West; Fiscal Year: 2007
    ..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
  9. Antimicrobial Dental Devices and Waterlines
    TED REID; Fiscal Year: 2007
    ..Finally, we will assess the efficacy of the coated tubing in flow cell experiments using Pseudomonas aeruginosa. [unreadable] [unreadable] [unreadable]..
  10. Who drives safely? Visual/cognitive predictors in Elders
    Sheila West; Fiscal Year: 2008
    ..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
  11. Yearly Mass Treatment C. Trachomatis: When Can We Stop?
    Sheila West; Fiscal Year: 2008
    ..unreadable] [unreadable]..