thyroiditis

Summary

Summary: Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.

Top Publications

  1. ncbi Riedel's thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis: positron emission tomographic findings
    Olivier Drieskens
    Department of Nuclear Medicine, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Nucl Med 27:413-5. 2002
  2. ncbi [Diagnosis of thyroid disease. Part 2: thyroid gland nodes, diagnosis and treatment of thyroid carcinoma]
    S Delorme
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebforschungszentrum, Heidelberg
    Radiologe 43:179-94; quiz 194-5. 2003
  3. ncbi Thyroiditis
    Elizabeth N Pearce
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 348:2646-55. 2003
  4. doi The natural history of interferon-alpha2b-induced thyroiditis and its exclusivity in a cohort of patients with chronic hepatitis C infection
    H A Tran
    Hunter Area Pathology Service, Newcastle University, Newcastle, New South Wales 2310, Australia
    QJM 102:117-22. 2009
  5. doi Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum
    Mollie Dahlgren
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Care Res (Hoboken) 62:1312-8. 2010
  6. ncbi Thyroiditis
    Archana Bindra
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am Fam Physician 73:1769-76. 2006
  7. ncbi Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves' disease
    Hisashi Ota
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 67:41-5. 2007
  8. doi Thyroid cancer, thyroiditis and dietary iodine: a review based on the Salta, Argentina model
    H Ruben Harach
    Servicio de Patologia, Hospital Dr A Oñativia, E Paz Chain 36, 4400 Salta, Argentina
    Endocr Pathol 19:209-20. 2008
  9. pmc Interferon-alpha-induced destructive thyroiditis followed by Graves' disease in a patient with chronic hepatitis C: a case report
    Bu Kyung Kim
    Department of Internal Medicine, Kosin University, College of Medicine, Busan, Korea
    J Korean Med Sci 26:1638-41. 2011
  10. pmc Interferon alpha treatment and thyroid dysfunction
    Yaron Tomer
    Division of Endocrinology, Cincinnati VA Medical Center, USA
    Endocrinol Metab Clin North Am 36:1051-66; x-xi. 2007

Research Grants

  1. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
  2. IMMUNOBIOLOGY OF TAMARIN COLITIS
    James Roche; Fiscal Year: 1990
  3. Functional Anergy in B Cells
    LAWRENCE WYSOCKI; Fiscal Year: 2009
  4. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 1999
  5. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
  6. ENDOCRINE AND AUTOIMMUNE DISORDERS IN THYROIDITIS
    JOSEPH KITE; Fiscal Year: 1980
  7. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2004
  8. HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPY
    WINIFRED DODDS; Fiscal Year: 1990
  9. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2001
  10. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2002

Detail Information

Publications206 found, 100 shown here

  1. ncbi Riedel's thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis: positron emission tomographic findings
    Olivier Drieskens
    Department of Nuclear Medicine, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Nucl Med 27:413-5. 2002
    The authors describe F-18 fluorodeoxyglucose positron emission tomographic (FDG PET) imaging features of Riedel's thyroiditis and retroperitoneal fibrosis in a patient with multifocal fibrosclerosis.
  2. ncbi [Diagnosis of thyroid disease. Part 2: thyroid gland nodes, diagnosis and treatment of thyroid carcinoma]
    S Delorme
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebforschungszentrum, Heidelberg
    Radiologe 43:179-94; quiz 194-5. 2003
  3. ncbi Thyroiditis
    Elizabeth N Pearce
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 348:2646-55. 2003
  4. doi The natural history of interferon-alpha2b-induced thyroiditis and its exclusivity in a cohort of patients with chronic hepatitis C infection
    H A Tran
    Hunter Area Pathology Service, Newcastle University, Newcastle, New South Wales 2310, Australia
    QJM 102:117-22. 2009
    ..In the former, the commonest aetiology is thyroiditis. As there is no previous data to fully characterize the entity of IFN-related thyroiditis, the aim of this ..
  5. doi Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum
    Mollie Dahlgren
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Care Res (Hoboken) 62:1312-8. 2010
    Riedel's thyroiditis is a chronic fibrosing disorder of unknown etiology often associated with "multifocal fibrosclerosis...
  6. ncbi Thyroiditis
    Archana Bindra
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am Fam Physician 73:1769-76. 2006
    b>Thyroiditis is an inflammation of the thyroid gland that may be painful and tender when caused by infection, radiation, or trauma, or painless when caused by autoimmune conditions, medications, or an idiopathic fibrotic process...
  7. ncbi Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves' disease
    Hisashi Ota
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 67:41-5. 2007
    ..It is, however, often difficult to make this distinction without measurement of radioactive iodine uptake. We investigated the possibility that assessment of thyroid blood flow would allow differentiation between the two entities...
  8. doi Thyroid cancer, thyroiditis and dietary iodine: a review based on the Salta, Argentina model
    H Ruben Harach
    Servicio de Patologia, Hospital Dr A Oñativia, E Paz Chain 36, 4400 Salta, Argentina
    Endocr Pathol 19:209-20. 2008
    ..Autoimmune focal and diffuse or Hashimoto's thyroiditis are linked to dietary iodine...
  9. pmc Interferon-alpha-induced destructive thyroiditis followed by Graves' disease in a patient with chronic hepatitis C: a case report
    Bu Kyung Kim
    Department of Internal Medicine, Kosin University, College of Medicine, Busan, Korea
    J Korean Med Sci 26:1638-41. 2011
    Interferon-induced thyroiditis (IIT) is a major clinical problem for patients receiving interferon-alpha (IFN-α) therapy. But, destructive thyroiditis followed by Graves' disease associated with IFN-α therapy is very rarely reported...
  10. pmc Interferon alpha treatment and thyroid dysfunction
    Yaron Tomer
    Division of Endocrinology, Cincinnati VA Medical Center, USA
    Endocrinol Metab Clin North Am 36:1051-66; x-xi. 2007
    ..In some cases IFN-induced thyroiditis (IIT) may result in discontinuation of interferon therapy; thus, IIT represents a major clinical problem for ..
  11. ncbi Rapid differential diagnosis of Graves' disease and painless thyroiditis using total T3/T4 ratio, TSH, and total alkaline phosphatase activity
    Tetsuo Yanagisawa
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo, Japan
    Endocr J 52:29-36. 2005
    ..in an outpatient clinic, it is important to make a differential diagnosis of Graves' disease (GD) and painless thyroiditis (PT)...
  12. ncbi De Quervain's subacute thyroiditis -- colour Doppler sonography findings
    A Kunz
    Dep of Internal Med, Klinikum am Steinenberg, Reutlingen
    Ultraschall Med 26:102-6. 2005
    De Quervain's subacute nonsuppurative thyroiditis has been well characterised clinically: there usually is pain in the region of the thyroid due to local pressure. Typically, the patient feels generally ill with fever...
  13. ncbi Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis
    Jaeduk Yoshimura Noh
    Ito Hospital, Tokyo, Japan
    Endocr J 52:537-42. 2005
    ..untreated patients with thyrotoxicosis (48 patients with Graves' disease and 34 patients with painless thyroiditis) were examined in Kuma Hospital, and 218 patients (126 with Graves' disease and 92 with painless thyroiditis) ..
  14. ncbi The clinical and physiological spectrum of interferon-alpha induced thyroiditis: toward a new classification
    Jamie C Mandac
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 43:661-72. 2006
    ..Some of these complications may result in discontinuation of interferon therapy. Thus, interferon induced thyroiditis (IIT) is a major clinical problem for patients receiving interferon therapy...
  15. ncbi Sunitinib (sutent)-induced thyrotoxicosis due to destructive thyroiditis: a case report
    Jason E Faris
    Department of Internal Medicine, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Thyroid 17:1147-9. 2007
    Numerous drugs have been associated with destructive thyroiditis (subacute thyroiditis)...
  16. ncbi Fungal thyroiditis: an overview
    Luciano Z Goldani
    Section of Infectious Diseases, Universidade Federal do Rio Grande do Sul, Brazil
    Mycopathologia 161:129-39. 2006
    The authors review the epidemiology, clinical manifestations, diagnosis, and treatment of fungal thyroiditis cases previously reported in the medical literature. Aspergillus was by far the most common cause of fungal thyroiditis...
  17. ncbi Acute suppurative thyroiditis in childhood: relative frequency among thyroid inflammatory diseases*
    M Wasniewska
    J Endocrinol Invest 30:346-7. 2007
  18. doi Palpation thyroiditis causing new-onset atrial fibrillation
    Vinh Q Mai
    Department of Endocrinology, National Naval Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Thyroid 18:571-3. 2008
    Surgery-induced thyroiditis can pose a significant clinical problem that is underappreciated...
  19. ncbi Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    ..However, a question arises whether such aggravation constitutes an adverse effect of the drugs or not...
  20. ncbi Post-partum thyroiditis in a mediterranean population: a prospective study of a large cohort of thyroid antibody positive women at the time of delivery
    M Kita
    Department of Endocrinology, Hippocration General Hospital, Thessaloniki, Greece
    J Endocrinol Invest 25:513-9. 2002
    Post-partum thyroiditis (PPT) is a common disease with important clinical sequelae...
  21. doi Environmental triggers of thyroiditis: hepatitis C and interferon-α
    F Menconi
    Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    J Endocrinol Invest 34:78-84. 2011
    ..Interferon induced thyroiditis (IIT) can manifest as non-autoimmune thyroiditis (presenting as destructive thyroiditis, or non-autoimmune ..
  22. ncbi Relevance of thyroiditis and of other autoimmune diseases in children with vitiligo
    Paolo Iacovelli
    San Gallicano Institute, IRCCS, Rome, Italy
    Dermatology 210:26-30. 2005
    ..Studies that clearly define the possible association of childhood vitiligo with autoimmune and/or endocrine diseases are lacking...
  23. ncbi Postpartum thyroiditis
    J H Lazarus
    Autoimmunity 35:169-73. 2002
    Post partum thyroiditis occurs in 50% of TPO AB+ve women and is characterised by transient hyperthyroidism followed by transient hypothyroidism during the first six months, post partum...
  24. ncbi MR findings with dynamic evaluation in Riedel's thyroiditis
    Naoya Takahashi
    Department of Radiology, Niigata University School of Medicine, 1 Asahimachi, Niigata, Niigata, Japan
    Clin Imaging 26:89-91. 2002
    We reported the findings on MRI in a patient with proven Riedel's thyroiditis. The lesion was seen as slightly heterogeneous hypointensity on both T1- and T2-weighted images and had a mild enhancement after administration of gadpentate ..
  25. ncbi Growth factor-expressing mast cells accumulate at the thyroid tissue-regenerative site of subacute thyroiditis
    S Toda
    Department of Pathology, Saga Medical School, Japan
    Thyroid 10:381-6. 2000
    The localization and biological roles of the multifunctional cell type mast cells remain unclear in subacute thyroiditis that is characterized by both epithelioid granuloma formation and thyroid tissue repair...
  26. ncbi Recovery from lymphocytic hypophysitis associated with painless thyroiditis: clinical implications of circulating antipituitary antibodies
    Y Ozawa
    Department of Internal Medicine, Toranomon Hospital, Tokyo, Japan
    Acta Endocrinol (Copenh) 128:493-8. 1993
    ..The other point to be emphasized in this case is the simultaneous development of painless thyroiditis and lymphocytic hypophysitis...
  27. ncbi Multifocal fibrosclerosis: a case of thyroiditis and bilateral lacrimal gland involvement
    K Owen
    Department of Medicine, Singleton Hospital, Swansea, Wales, United Kingdom
    Thyroid 11:1187-90. 2001
    A patient with invasive fibrous thyroiditis (Riedel's thyroiditis), dysphagia, and bilateral lacrimal gland involvement is described. Resolution of the thyroid mass and orbital swellings followed corticosteroid therapy...
  28. ncbi [Acquired childhood and juvenile subclinical hypothyroidism with or without goitre]
    Jean Pierre Cordray
    Groupe de Recherches Cliniques en Endocrinologie, Paris 75, France
    Presse Med 34:285-8. 2005
    Primary acquired childhood and juvenile hypothyroidism is mainly due to chronic thyroiditis or to the after effects of cervical radiotherapy for cancer...
  29. ncbi Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care
    A F Muller
    Department of Immunology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
    Endocr Rev 22:605-30. 2001
    Postpartum thyroiditis is a syndrome of transient or permanent thyroid dysfunction occurring in the first year after delivery and based on an autoimmune inflammation of the thyroid. The prevalence ranges from 5-7%...
  30. doi A case of pheochromocytoma complicated with slowly progressive type 1 diabetes mellitus and chronic thyroiditis
    Koji Murao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun 761 0793, Kagawa, Japan
    Endocrine 32:350-3. 2007
    ..report regarding a 45-year-old woman, who has been undergoing treatment for diabetes mellitus (DM) with chronic thyroiditis (euthyroid state)...
  31. pmc Interferon induced thyroiditis
    Yaron Tomer
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, Box 1118, One Gustave L Levy Place, New York, NY 10029, USA
    Best Pract Res Clin Endocrinol Metab 23:703-12. 2009
    ..One of the commonest side effects of IFNalpha therapy is thyroiditis, with up to 40% of HCV patients on IFNalpha developing clinical or subclinical disease...
  32. ncbi Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease
    Nathalie Lévy Bohbot
    Service d endocrinologie, Centre Hospitalier Universitaire de Reims, Hopital Robert Debre, France
    Eur J Endocrinol 154:367-72. 2006
    ..hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease...
  33. ncbi Steroid responsiveness in a case of Riedel's thyroiditis and retroperitoneal fibrosis
    P K Moulik
    Department of Medicine, Halton General Hospital, Runcorn, UK
    Int J Clin Pract 58:312-5. 2004
    Riedel's thyroiditis is a rare chronic inflammatory disease of the thyroid characterised by an invasive fibrotic process...
  34. ncbi Evaluation of thyroid hormone action in a case of generalized resistance to thyroid hormone with chronic thyroiditis: discovery of a novel heterozygous missense mutation (G347A)
    Haruhiro Sato
    Department of Medicine, Tokai University School of Medicine, Tokyo, Japan
    Endocr J 54:727-32. 2007
    ..We describe a 21-year-old Japanese woman with GRTH and coincidental chronic thyroiditis. Physical examination revealed palpable goiter, congenital alopecia on top of the head, and short stature...
  35. ncbi Association between lithium use and thyrotoxicosis caused by silent thyroiditis
    K K Miller
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 55:501-8. 2001
    OBJECTIVE: To determine the incidence of silent thyroiditis in lithium users and characterize lithium-associated thyrotoxicosis. DESIGN: Retrospective record review...
  36. ncbi Stimulation of thyroid-stimulating hormone (TSH) receptor antibody production following painless thyroiditis
    Makoto Iitaka
    Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, Japan
    Clin Endocrinol (Oxf) 60:49-53. 2004
    Development or recurrence of Graves' disease (GD) following painless thyroiditis (PT) has been documented...
  37. doi Detection of enterovirus RNA in postoperative thyroid tissue specimens
    Rachel Desailloud
    Laboratoire de Virologie UPRES EA3610 Faculté de Médecine, Universite Lille 2, CHRU Lille, Lille, France
    Clin Endocrinol (Oxf) 70:331-4. 2009
    Autoimmune thyroiditis is a very common disease. A genetic predisposition and environmental factors such as viruses are thought to contribute to the development of autoimmune thyroiditis...
  38. ncbi Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor
    S Costagliola
    IRIBHN, ULB, Euroscreen s a, Louvain Medical School, Brussels, Belgium
    J Immunol 160:1458-65. 1998
    ..We conclude that genetic immunization is an efficient method of generating Abs recognizing the native structure of the hTSHR and a new way of inducing thyroiditis in mice murine.
  39. doi Drug-induced thyroiditis and papillary carcinoma in a minocycline-pigmented black thyroid gland
    Lyndal Tacon
    Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
    Thyroid 18:795-7. 2008
    ..was no evidence of Graves' disease or autonomous nodule on thyroid scintigraphy, and a clinical diagnosis of thyroiditis was made...
  40. ncbi An unusual form of Riedel's thyroiditis: a case report and review of the literature
    S Fontaine
    Department of Endocrinology, CHU Rangueil, Toulouse, France
    Thyroid 15:85-8. 2005
    ..A total thyroidectomy was performed. Histopathologic findings led to the diagnosis of Riedel's thyroiditis. We observed a dramatic improvement after surgery with absence of fever and normalization of inflammatory ..
  41. ncbi Occurrence of Riedel's thyroiditis in the course of sub-acute thyroiditis
    T Kabalak
    Ege University Endocrinology Department, Bornova Izmir, Turkey
    J Endocrinol Invest 23:399-401. 2000
    Riedel's Thyroiditis is an uncommon form of chronic thyroiditis characterized by an invasive fibrosclerosis of the gland, often involving surrounding tissue...
  42. ncbi Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis
    Bamini Gopinath
    Thyroid Research Laboratory, Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW 2751, Australia
    Thyroid 17:1123-9. 2007
    There have been reports of the development of ophthalmopathy in patients with subacute thyroiditis (SAT) in the absence of Graves' disease and thyroid-stimulating hormone receptor (TSH-r) antibodies.
  43. ncbi [Concurrence of myasthenia gravis, polymyositis, thyroiditis and eosinophilia in a patient with type B1 thymoma]
    Manabu Inoue
    Department of Neurology, Ijinkai Takeda General Hospital
    Rinsho Shinkeigaku 47:423-8. 2007
    ..After the thymectomy, corticosteroid administration and immunoadsorption therapy, clinical symptoms and all laboratory abnormalities markedly improved...
  44. ncbi Riedel's thyroiditis treated with tamoxifen
    Nina Dabelic
    Department of Oncology and Nuclear Medicine, Sisters of Mercy University Hospital, Vinogradska 29, 10000 Zagreb, Croatia
    Croat Med J 44:239-41. 2003
    A 46-year-old woman with clinical diagnosis of Riedel's thyroiditis was admitted to our Department, presenting with dyspnea, dysphagia, fatigue, and hoarseness...
  45. pmc Viruses and thyroiditis: an update
    Rachel Desailloud
    Laboratoire de Virologie UPRES EA3610 Faculté de Médecine, Universite Lille 2, CHRU Lille, Centre de Biologie Pathologie et Parc Eurasanté, 59037 Lille, France
    Virol J 6:5. 2009
    Viral infections are frequently cited as a major environmental factor involved in subacute thyroiditis and autoimmune thyroid diseases This review examines the data related to the role of viruses in the development of thyroiditis...
  46. ncbi Transient thyroiditis after treatment with lenalidomide in a patient with metastatic renal cell carcinoma
    Emily M Stein
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Thyroid 17:681-3. 2007
    ..features of this patient's presentation are most consistent with immune-mediated subacute destructive thyroiditis. This case highlights the importance of monitoring thyroid function in the growing number of patients being ..
  47. ncbi Riedel's thyroiditis and fibrous variant of Hashimoto's thyroiditis: a clinicopathological and immunohistochemical study
    G Papi
    Department of Internal Medicine, A U S L Modena, Italy
    J Endocrinol Invest 26:444-9. 2003
    The aim of this study was to analyze and compare clinico pathological aspects of Riedel's thyroiditis (RT) and the fibrous variant of Hashimoto's thyroiditis (HTFV), and to show their immunohistochemical features...
  48. ncbi CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis
    Gregory D Sempowski
    Department of Medicine and the Duke University Human Vaccine Institute, Duke University Medical Center, Box 3258, Research Park Building 1, Room 113, Research Drive, Durham, NC 27710, USA
    J Immunol 172:787-94. 2004
    ..b>Thyroiditis developed in aged CD7/CD28-double-deficient mice (>1 year) that was not seen in age-matched control mice or ..
  49. ncbi Intrathyroidal branchial cleft-like cyst in chronic thyroiditis
    R Haba
    First Department of Pathology, Kagawa Medical School, Kagawa, Japan
    Pathol Int 50:897-900. 2000
    ..The patient is currently well with no evidence or recurrence for 43 months...
  50. ncbi Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice
    Sandra M McLachlan
    Autoimmune Disease Unit, Cedars Sinai Research Institute and University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Endocrinology 146:294-300. 2005
    ..predisposed to thyroid autoimmunity and spontaneously develop thyroglobulin autoantibodies (TgAb) and thyroiditis. Iodide administration enhances TgAb levels and the incidence and severity of thyroiditis...
  51. ncbi Cytological correlation in patients who have a pre-diagnosis of thyroiditis ultrasonographically
    Ozlem Aydin
    Department of Pathology, Mersin University Medical School, Mersin Icel, Turkey
    Endocr Res 29:97-106. 2003
    Radiological-cytopathological correlation in patients who are prediagnosed ultrasonographically as thyroiditis.
  52. ncbi Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice
    P R Hutchings
    Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom
    Cell Immunol 192:113-21. 1999
    ..diabetes mellitus, displays a tendency in common with human diabetic populations to develop autoimmune thyroiditis although incidence and severity of thyroid lesions vary widely among different colonies around the world...
  53. ncbi Postpartum thyroiditis: epidemiology and clinical evolution in a nonselected population
    A Lucas
    Endocrinology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain
    Thyroid 10:71-7. 2000
    Postpartum thyroiditis (PPT) presents in approximately 5% of women. Its incidence, clinical characteristics, and evolution were studied in a nonselected population of Mediterranean women...
  54. ncbi [Subclinical hypothyroidism]
    Toshihiko Yokota
    Department of Endocrinology and Rheumatology, Kurashiki Central Hospital
    Nihon Rinsho . 2006
  55. ncbi Glucocorticoid response in amiodarone-induced thyrotoxicosis resulting from destructive thyroiditis is predicted by thyroid volume and serum free thyroid hormone concentrations
    Fausto Bogazzi
    Department of Endocrinology, University of Pisa, Ospedale Cisanello, Via Paradisa, 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:556-62. 2007
    Amiodarone-induced thyrotoxicosis (AIT) resulting from destructive thyroiditis (type 2) is commonly treated with glucocorticoids, but time needed to restore euthyroidism may be unacceptable for patients with underlying cardiac disorders.
  56. ncbi Radionuclide imaging of the thyroid gland: patterns, pearls, and pitfalls
    Joel R Smith
    Department of Radiology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Clin Nucl Med 29:181-93. 2004
    ..By integrating the interpretive and technical "pearls" and "pitfalls" outlined in this article, the radiologist can be more confident in establishing a proper diagnosis...
  57. ncbi Radiotherapy-induced thyroid disorders
    Barbara A Jereczek-Fossa
    Department of Radiation Oncology, European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    Cancer Treat Rev 30:369-84. 2004
    ..These sequelae may include primary or central hypothyroidism, thyroiditis, Graves' disease, euthyroid Graves' ophthalmopathy, benign adenomas, multinodular goitre and radiation-induced ..
  58. ncbi [Spectrometric assessment of thyroid depth within the radioiodine test]
    T Rink
    Abteilung für Nuklearmedizin, Klinikum Stadt Honau, J W Goethe Universität Frankfurt, Main
    Nuklearmedizin 44:192-6. 2005
    ..Aim of this study is the validation of a simple method for evaluating the depth of the target volume within the radioiodine test by analyzing the emitted iodine-131 energy spectrum...
  59. ncbi Thyroid hemiagenesis with postpartum silent thyroiditis
    Shigenori Nakamura
    Department of Internal Medicine, Gifu Red Cross Hospital, Gifu
    Intern Med 43:306-9. 2004
    ..This clinical course indicates that she developed silent thyroiditis after the delivery...
  60. ncbi [Thyroid diseases in sub-Saharan Africa]
    El Hassane Sidibé
    Centre médical Marc Sankalé, BP 5062, Fann Dakar, Senegal
    Sante 17:33-9. 2007
    ..2%), most often with euthyroid goiters (54.7%), followed by Graves disease (13.1%), hypothyroidism (8.8%), thyroiditis (6.6%), toxic multinodular goiters (6.6 %) and unclassified goiters (10%) [Gabon]...
  61. ncbi Thyroid pathology and the globus symptom: are they related? A two year prospective trial
    P Burns
    Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    J Laryngol Otol 121:242-5. 2007
    ..The globus sensation is a constant feeling of a lump in the throat and may be associated with thyroid enlargement. A two year prospective study was set up to ascertain the relationship between thyroid pathology and globus symptoms...
  62. ncbi The incidence of gestational hyperthyroidism and postpartum thyroiditis in treated patients with Graves' disease
    Tetsuya Tagami
    Clinical Research Institute, Division of Endocrinology and Metabolism, Kyoto Medical Center, National Hospital Organization, Kyoto 612 8555, Japan
    Thyroid 17:767-72. 2007
    ..Postpartum transient thyroiditis (PTT) is a destructive thyroiditis induced by autoimmune mechanism in the postpartum period...
  63. ncbi Induction of goitrous hypothyroidism by dietary iodide in SJL mice
    Haiyan S Li
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Endocrinology 148:2747-52. 2007
    ..the incidence of goiter and/or hypothyroidism in humans as well as animals prone to spontaneous autoimmune thyroiditis. In the current study, we investigated the role of dietary iodide on the development of hypothyroidism, as well ..
  64. ncbi [Current thyroid diagnostics and therapy in disorders of fertility and in pregnancy]
    Heike J Fink
    Medizinische Klinik, Akademisches Lehrkrankenhaus des Universitätsklinikums Schleswig Holstein, Campus Lubeck
    Med Klin (Munich) 101:645-52; quiz 653-4. 2006
  65. ncbi [Sonography of the thyroid]
    W Wiesner
    Medizinisch Radiologisches Zentrum, Klinik Stephanshorn, St Gallen
    Praxis (Bern 1994) 95:575-80. 2006
    ....
  66. ncbi Hyperthyroidism
    Bindu Nayak
    Division of Endocrinology and Metabolism, Georgetown University Hospital, 4000 Reservoir Road, Building D, Suite 232, Washington, DC 20007, USA
    Endocrinol Metab Clin North Am 36:617-56, v. 2007
    ..Thyrotoxicosis is a condition resulting from elevated levels of thyroid hormone. In this article, the authors review the presentation, diagnosis, and management of various causes of thyrotoxicosis...
  67. ncbi Usefulness of the 2nd generation assay for anti-TSH receptor antibodies to differentiate relapse of Graves' thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for Graves' disease
    Yukiko Izumi
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Osaka
    Endocr J 52:493-7. 2005
    ..antithyroid drug (ATD) treatment for Graves' disease, either a relapse of Graves' thyrotoxicosis or painless thyroiditis can develop...
  68. ncbi [Dysplasias and tumors of the thyroid gland]
    M V Fridman
    Vopr Onkol 52:205-8. 2006
  69. ncbi Association between human leukocyte antigen (HLA) and interferon- induced thyroid diseases in four patients with HCV-related chronic hepatitis
    Giancarlo Labbadia
    Department of Medical Therapy, Faculty of Medicine, University of Rome La Sapienza, Italy
    Neuro Endocrinol Lett 26:109-12. 2005
    ..The interferon-alpha (IFN-alpha) therapy for HCV hepatitis may exacerbate or induce underlying thyroid disorders. Besides viral factors, the human leukocyte antigen (HLA) may be an independent risk factor...
  70. ncbi Treatment of post-partum thyrotoxicosis
    F Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 19395 4763, Tehran, IR Iran
    J Endocrinol Invest 29:244-7. 2006
    ..Graves' disease and post-partum thyroiditis are two major causes of thyrotoxicosis in this period...
  71. ncbi [Surgery of the thyroid gland. I]
    C L Weiss
    Martin Luther Universitat Halle Wittenberg, Universitätsklinik für Allgemeinchirurgie, Halle Saale
    Zentralbl Chir 129:W76-83. 2004
  72. ncbi Thyroid evaluation in patients with primary hyperparathyroidism
    Toshihiro Masatsugu
    Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan
    Endocr J 52:177-82. 2005
    ..Eight (88.9%) of the 9 non-palpable thyroid cancers were accurately diagnosed by combined US and US-FNAB. Preoperative US is useful for evaluation of possible concomitant thyroid disease, especially for prediction of malignancy...
  73. ncbi Immunohistochemistry differentiates papillary thyroid carcinoma arising in ectopic thyroid tissue from secondary lymph node metastases
    Daniela Cabibi
    Human Pathology Department, University School of Medicine, Via del Vespro, Palermo, Italy
    Thyroid 17:603-7. 2007
    ..To verify whether immunohistochemistry might be useful in the distinction between a true laterocervical metastasis of an undetected thyroid carcinoma and a primary tumor outside the gland...
  74. ncbi [Subacute thyroiditis and silent thyroiditis]
    Kouki Mori
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
    Nihon Rinsho 63:122-6. 2005
  75. ncbi [Treatment of hyperthyroidisms in Brazzaville Teaching Hospital, Congo]
    H G Monabeka
    Service des maladies métaboliques et endocriniennes CHU Brazzaville, Congo
    Bull Soc Pathol Exot 98:91-3. 2005
    ..6%) had toxic multinodular goitre while the rest had toxic adenoma (7.6%), and thyroiditis (4.2%). The mean age was 26.6 +/- 7.9 years for Graves' cases and 49.4 +/- 9...
  76. pmc Diagnosis and management of thyrotoxicosis
    Elizabeth N Pearce
    Boston University Medical Center, 88 East Newton Street, Evans 201, Boston, MA 02118, USA
    BMJ 332:1369-73. 2006
  77. ncbi Two cases of atrophic thyroiditis with unilateral low radioiodine uptake on the right lobe in thyroid scintigram
    Michiyo Mizota
    Department of Pediatrics, Kagoshima University, Kagoshima, Japan
    Pediatr Int 47:456-8. 2005
  78. ncbi High diagnostic value of a radioiodine uptake test with and without iodine restriction in Graves' disease and silent thyroiditis
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Thyroid 14:531-5. 2004
    ..RAIU value, and the necessity of iodine restriction in differentiating between Graves' disease (GD) and silent thyroiditis (ST)...
  79. ncbi Role of FNAC and antithyroid antibodies in the diagnosis of thyroid disorders
    Syed Riaz Mehdi
    Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh
    Indian J Pathol Microbiol 46:184-90. 2003
    ..The cases were divided into four groups. Cases of thyroiditis on FNAC showed predominance of lymphocytes (76%), hurthle cells (77%), epithelioid cells and giant cells (31%) ..
  80. ncbi Peroxiredoxin I expression in human thyroid tumors
    T Yanagawa
    Division of Head and Neck Surgery, Chiba Cancer Center Hospital, Japan
    Cancer Lett 145:127-32. 1999
    ..The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting...
  81. ncbi [Thyroiditis in patients operated on for goiter]
    Wojciech Cichoń
    Klinika Chirurgii Endokrynologicznej, III Katedry Chirurgii Ogólnej, Collegium Medicum, Uniwersytetu Jagiellonskiego, Krakow
    Przegl Lek 59:129-31. 2002
    The paper is aimed at evaluating the frequency of incidence and the thyroiditis type in patients operated on for goiter. In the years 1989-2000, 5149 patients were operated on because of different thyroid disorders...
  82. ncbi Simple and practical parameters for differentiation between destruction-induced thyrotoxicosis and Graves' thyrotoxicosis
    Yukiko Izumi
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Clin Endocrinol (Oxf) 57:51-8. 2002
    ..It is, however, often difficult to make this distinction without measurement of radioactive iodine uptake. We searched for simple and practical parameters that might allow differentiation between the two entities...
  83. ncbi [Thyroid gland diagnosis. 1: Diffuse diseases, epithelial bodies]
    S Delorme
    Abteilung Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg
    Radiologe 42:309-25; quiz 326-7. 2002
  84. ncbi Management of thyrotoxicosis
    Joseph N Fisher
    Department of Medicine, University of Tennessee Health Science Center, Memphis 38163, USA
    South Med J 95:493-505. 2002
  85. ncbi The use of dual phase 201Tl thyroid scan for equivocal fine-needle aspiration results in cold thyroid nodules
    C C Lin
    Department of Family Medicine, China Medical College Hospital, Taichung, Taiwan
    Anticancer Res 21:2969-72. 2001
    ..We concluded that dual phase Tl thyroid scan was very helpful in differentiating between benign and malignant thyroid nodules when FNA results were equivocal...
  86. ncbi Prevalence and characteristics of postpartum thyroid dysfunction in Tehran
    H B Shahbazian
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Eur J Endocrinol 145:397-401. 2001
    OBJECTIVE: To determine the prevalence of postpartum thyroiditis (PPT), one of the autoimmune disorders of the thyroid which usually occurs in women in the first year after parturition...
  87. doi Influence of L-thyroxine therapy on parathyroid hormone concentrations
    Adonios Zanglis
    Clin Chem 54:1092-3. 2008
  88. ncbi Induction of autoimmune hypothyroidism and subsequent hyperthyroidism by TSH receptor antibodies following subacute thyroiditis: a case report
    M Iitaka
    Fourth Department of Internal Medicine, Saitama Medical School, Japan
    Endocr J 48:139-42. 2001
    A 45 year-old man had a typical episode of subacute thyroiditis with tender goiter, depressed radioiodine uptake (RAIU) and elevated erythrocyte sedimentation rate...
  89. ncbi [A comparative study of cytological and histological studies of the thyroid gland]
    P Emmrich
    ,
    Zentralbl Chir 126:267-72. 2001
    ..The groups I and II contained cases with multinodular goitre, thyroiditis and follicular adenomas, but 4 carcinomas too...
  90. ncbi Thyroid cytology and the risk of malignancy in thyroid nodules: importance of nuclear atypia in indeterminate specimens
    A S Kelman
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Thyroid 11:271-7. 2001
    ..For nodules with benign FNA cytologic diagnoses of nodular goiter and chronic thyroiditis there was a low risk of malignancy (6/99, or 6.1%)...
  91. ncbi Platelet-activating factor and human thyroid cancer
    Yves Denizot
    UMR CNRS 6101, Faculte de Medecine, Limoges, France
    Eur J Endocrinol 153:31-40. 2005
    ....
  92. ncbi Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans
    G Sauter
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    Horm Metab Res 29:176-9. 1997
    ..6 ng/ml vs 14.7 +/- 8.1 ng/ml before treatment, n.s.). These findings indicate that in humans, thyroid hormones influence serum lipid concentrations by other mechanisms than by affecting the activity of cholesterol 7 alpha-hydroxylase...
  93. ncbi Foetal and neonatal thyroid disorders
    G Radetti
    Departments of Pediatrics, Regional Hospital of Bolzano, Bolzano, Italy
    Minerva Pediatr 54:383-400. 2002
    ..The most common causes are maternal thyroid autoimmune disorders, such as Graves' disease and Hashimoto's thyroiditis. Rarer non autoimmune causes recently identified are represented by TSH receptor mutations leading to ..
  94. ncbi [Subacute thyroiditis with cell destruction and temporary hyperthyroidism in Graves'disease--case report]
    R Pichler
    Institut für Nuklearmedizin und Endokrinologie, Allgemeines Krankenhaus Linz, Krankenhausstrasse 9, A 4020 Linz
    Acta Med Austriaca 29:137-40. 2002
    ..Three months later hypothyroidism was observed requiring treatment with levothyroxine. The development of subacute thyroiditis and Graves' disease in the same person is rare, autoimmune factors and a possible relationship are discussed.
  95. ncbi Fine-needle aspiration of Riedel's disease: report of a case and review of the literature
    Malini Harigopal
    Department of Pathology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    Diagn Cytopathol 30:193-7. 2004
    The cytomorphological features of a case of Riedel's thyroiditis (Riedel's disease) in a 37-yr-old woman are reviewed...
  96. ncbi Visual vignette. Riedel's fibrosing thyroiditis
    Rajaa Nahra
    Section of Endocrinology and Diabetes, Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA
    Endocr Pract 9:571. 2003
  97. ncbi Possible induction of Graves' disease and painless thyroiditis by gonadotropin-releasing hormone analogues
    Nobuyuki Amino
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Thyroid 13:815-8. 2003
    ..Another patient developed painless thyroiditis in association with an increase in antithyroid microsomal antibodies at 4 months after initiation of leuprolide ..
  98. ncbi The treatment of post-partum thyroid disease
    P J D Owen
    J Endocrinol Invest 26:290-1. 2003
  99. ncbi The mechanisms of autoimmunity in endocrinology: application to the thyroid gland
    A P Weetman
    University of Sheffield Clinical Sciences Centre, Northern General Hospital, Sheffield, S57AU, United Kingdom
    Ann Endocrinol (Paris) 64:26-7. 2003
  100. ncbi Hypothyroidism and women's health
    Geoffrey P Redmond
    Hormone Center of New York, Center for Health Research, Inc, New York 10021, USA
    Int J Fertil Womens Med 47:123-7. 2002
    ..Confirmation of diagnosis is based on laboratory tests, not symptoms. With Hashimoto's thyroiditis, the most common cause, the thyroid is usually firm and irregular to palpation...
  101. ncbi [The thyroid pyramidal lobe: frequency, morphological features and related diseases]
    Giovanni Sturniolo
    Cattedra di Chirurgia Generale, UOC di Chirurgia Generale a Indirizzo Endocrino, Universita degli Studi di Messina, Messina
    Chir Ital 60:41-6. 2008
    ..5% of cases, mostly in women, the primary disease invariably arising from the main gland. The Authors conclude that the pyramidal lobe is an embryological remnant which may be involved in diseases arising from the main gland...

Research Grants78

  1. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
    ..Cd is associated with secondary autoimmunity, such as type 1 diabetes or autoimmune thyroiditis, and longterm Cd that has not been treated with a strict gluten free diet can lead to (gastrointestinal) ..
  2. IMMUNOBIOLOGY OF TAMARIN COLITIS
    James Roche; Fiscal Year: 1990
    ..immune responses are causative of inflammation and/or dysfunction of a target organ (autoimmune thyroiditis, with of inflammation and/or dysfunction of a target organ (autoimmune thyroiditis, with thyroglobulin; ..
  3. Functional Anergy in B Cells
    LAWRENCE WYSOCKI; Fiscal Year: 2009
    ..type I diabetes, arthritis, systemic lupus erythematosus, myasthenia gravis, graves disease, Hashimoto's thyroiditis, pemphigus vulgaris, celiac disease, ulcerative colitis, scleroderma, autoimmune uveitis, hemolytic anemia and ..
  4. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 1999
    ..DBS specimens from the following three populations who are at high risk for the development of autoimmune thyroiditis and hypothyroidism: (a) An elderly population currently Living in Nursing and Personal Care Homes will be ..
  5. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
    ..DBS specimens from the following three populations who are at high risk for the development of autoimmune thyroiditis and hypothyroidism: (a) An elderly population currently Living in Nursing and Personal Care Homes will be ..
  6. ENDOCRINE AND AUTOIMMUNE DISORDERS IN THYROIDITIS
    JOSEPH KITE; Fiscal Year: 1980
    ..examine the endocrine, immune and genetic parameters that may affect the development of spontaneous autoimmune thyroiditis in Obese strain chickens...
  7. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2004
    ..genetic factors interact to spontaneously induce organ-specific autoimmunity, insulitis and diabetes as well as thyroiditis. We expect that segments of the disease pathway defined by these factors will also be involved in the ..
  8. HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPY
    WINIFRED DODDS; Fiscal Year: 1990
    ..production, availability and/or reactivity; iii) reduces levels of antithyroid antibodies present in autoimmune thyroiditis which may interfere with hemostasis; and iv) alters endothelial cell metabolism...
  9. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2001
    ..genetic factors interact to spontaneously induce organ-specific autoimmunity, insulitis and diabetes as well as thyroiditis. We expect that segments of the disease pathway defined by these factors will also be involved in the ..
  10. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2002
    ..genetic factors interact to spontaneously induce organ-specific autoimmunity, insulitis and diabetes as well as thyroiditis. We expect that segments of the disease pathway defined by these factors will also be involved in the ..
  11. GENETIC CONTROL OF BB RAT AUTOIMMUNITY
    Ake Lernmark; Fiscal Year: 2000
    ..genetic factors interact to spontaneously induce organ-specific autoimmunity, insulitis and diabetes as well as thyroiditis. We expect that segments of the disease pathway defined by these factors will also be involved in the ..
  12. GENETIC CONTROL OF BB RAT AUTOIMMUNITY.
    Ake Lernmark; Fiscal Year: 2003
    ..genetic factors interact to spontaneously induce organ-specific autoimmunity, insulitis and diabetes as well as thyroiditis. We expect that segments of the disease pathway defined by these factors will also be involved in the ..
  13. AUTOIMMUNE THYROIDITIS IN OS CHICKENS
    Noel Rose; Fiscal Year: 1980
    ..is the finding that the neonatal injection of large amounts of thyroglobulin tolerizes OS chickens and prevents thyroiditis. In conclusion, the OS and CS chickens have abnormal thyroid glands which may predispose them to autoimmune ..
  14. Celiac Disease: From Genetic Risk to Disease Development
    Susan Neuhausen; Fiscal Year: 2009
    ..Aim 2 is to investigate the prevalence of auto-antibodies that serve as biomarkers for thyroiditis, type I diabetes, pernicious anemia, and rheumatoid arthritis in CD cases...
  15. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..Aim 2 is to investigate the prevalence of auto-antibodies that serve as biomarkers for thyroiditis, type I diabetes, pernicious anemia, and rheumatoid arthritis in CD cases...
  16. GRAVES DISEASE AND HASHIMOTO THYROIDITIS
    Basil Rapoport; Fiscal Year: 1993
    ..study the thyroid-specific proteins that are the target of the immune system in Graves' disease and Hashimoto's thyroiditis. These proteins include the TSH receptor, the thyroid "microsomal" antigen, and other autoimmune thyroid ..
  17. IMMUNE RESPONSE TO THYROID PEROXIDASE IN THYROID CANCER
    James Baker; Fiscal Year: 1993
    ..the cellular immunotherapy of thyroid cancer comes from its role as the major human autoantigen in autoimmune thyroiditis. In this disorder, an intense lymphocytic thyroiditis is associated with cytotoxic cellular immunity to thyroid ..
  18. RETROVIRAL ETIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    Andrew Mason; Fiscal Year: 2001
    ..PBC patients are also prone to develop other autoimmune diseases such as Sjogren's syndrome, thyroiditis, and systemic lupus erythematosus...
  19. RETROVIRAL ETIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    Andrew Mason; Fiscal Year: 2000
    ..PBC patients are also prone to develop other autoimmune diseases such as Sjogren's syndrome, thyroiditis, and systemic lupus erythematosus...
  20. RETROVIRAL ETIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    Andrew Mason; Fiscal Year: 2002
    ..PBC patients are also prone to develop other autoimmune diseases such as Sjogren's syndrome, thyroiditis, and systemic lupus erythematosus...
  21. Thyroid Epithelial Cell Hyperplasia: Mechanisms of Induction
    Helen Mullen; Fiscal Year: 2009
    Wild-type (WT) and IL-4-/- NOD.H-2h4 mice given 0.05% NaI water develop lymphocytic spontaneous autoimmune thyroiditis (L-SAT) with B and T cell infiltration of the thyroid, and production of anti-thyroglobulin antibody...
  22. Thyroid Epithelial Cell Hyperplasia: Mechanisms of Induction
    HELEN B MULLEN; Fiscal Year: 2010
    Wild-type (WT) and IL-4-/- NOD.H-2h4 mice given 0.05% NaI water develop lymphocytic spontaneous autoimmune thyroiditis (L-SAT) with B and T cell infiltration of the thyroid, and production of anti-thyroglobulin antibody...
  23. IMMUNOTOXIC EFFECTS OF IODINE
    C Burek; Fiscal Year: 1992
    ..to iodine from dietary or therapeutic sources may contribute to the escalating prevalence of autoimmune thyroiditis in humans...
  24. REGULATION OF THYROID FUNCTION T4 AND T3 KINETICS
    Lewis Braverman; Fiscal Year: 1990
    ..ciamexone) will be used in an attempt to prevent the occurrence of spontaneous and iodine induced lymphocytic thyroiditis (LT) in the BB/Wor rat...
  25. New Rat Model For Autoimmune Therapy Safety/Efficacy
    Barbara Whalen; Fiscal Year: 2010
    ..1WR1 rat as a model of rheumatoid arthritis 3. Determine if the diabetic LEW.1WR1 rat develops thyroiditis, celiac disease, adrenal insufficiency, and sialadentis for use as a model of these disorders...
  26. T CELL RECOGNITION--REPERTOIRE IN AUTOIMMUNE THYROIDITIS
    YI CHI KONG; Fiscal Year: 2000
    The overall goal is to use murine experimental autoimmune thyroiditis (eat) as a model to probe the recognitory and pathogenic mechanisms leading to thyroid damage in Hashimoto's thyroititis (HT), the hypothyroid syndrome...
  27. T CELL RECOGNITION--REPERTOIRE IN AUTOIMMUNE THYROIDITIS
    YI CHI KONG; Fiscal Year: 1999
    The overall goal is to use murine experimental autoimmune thyroiditis (eat) as a model to probe the recognitory and pathogenic mechanisms leading to thyroid damage in Hashimoto's thyroititis (HT), the hypothyroid syndrome...
  28. T CELL RECOGNITION--REPERTOIRE IN AUTOIMMUNE THYROIDITIS
    YI CHI KONG; Fiscal Year: 2001
    The overall goal is to use murine experimental autoimmune thyroiditis (eat) as a model to probe the recognitory and pathogenic mechanisms leading to thyroid damage in Hashimoto's thyroititis (HT), the hypothyroid syndrome...
  29. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1991
    ..administration has been shown to ameliorate several different animal models of autoimmunity (autoimmune thyroiditis, systemic lupus, adjuvant-induced arthritis, and experimental allergic encephalomyelitis)...
  30. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1993
    ..administration has been shown to ameliorate several different animal models of autoimmunity (autoimmune thyroiditis, systemic lupus, adjuvant-induced arthritis, and experimental allergic encephalomyelitis)...
  31. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis Diaz; Fiscal Year: 2009
    ..At the completion of this application we will have a better understanding of other human autoimmune diseases like lupus erythematosus, rheumatoid arthritis, thyroiditis, and others.
  32. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2010
    ..At the completion of this application we will have a better understanding of other human autoimmune diseases like lupus erythematosus, rheumatoid arthritis, thyroiditis, and others.
  33. GENERAL CLINICAL RESEARCH CENTER
    Michael Yost; Fiscal Year: 1991
    ..The incidence of thyroid disease in children of patients with Graves' disease and Hashimoto's thyroiditis will be investigated as will the course of development of thyroid abnormalities in these children...
  34. Interferon-gamma: its role in autoimmune thyroiditis and thyroid function
    Patrizio Caturegli; Fiscal Year: 2006
    Interferon gamma (IFNgamma) has been implicated in the pathogenesis of autoimmune (Hashimoto's) thyroiditis. We have generated transgenic mice that express IFNg specifically in the thyroid gland, and shown that IFNgamma a) directly ..
  35. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
    Interferon gamma (IFNgamma) has been implicated in the pathogenesis of autoimmune (Hashimoto's) thyroiditis. We have generated transgenic mice that express IFNg specifically in the thyroid gland, and shown that IFNgamma a) directly ..
  36. IFNg role in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2005
    Interferon gamma (IFNgamma) has been implicated in the pathogenesis of autoimmune (Hashimoto's) thyroiditis. We have generated transgenic mice that express IFNg specifically in the thyroid gland, and shown that IFNgamma a) directly ..
  37. IMMUNOTOXIC EFFECTS OF IODINE
    C Burek; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the investigator's Abstract) Autoimmune thyroiditis is a multifactorial condition with several genetic and environmental components contributing to disease. Iodine has been implicated as one of these components...
  38. IMMUNOTOXIC EFFECTS OF IODINE
    C Burek; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the investigator's Abstract) Autoimmune thyroiditis is a multifactorial condition with several genetic and environmental components contributing to disease. Iodine has been implicated as one of these components...
  39. Ret Signaling in Paraneoplastic Peripheral Neuropathy
    JOSEPHINE FOX; Fiscal Year: 2009
    This is a research plan to investigate whether peripheral neuropathy, observed in Hashimoto's thyroiditis patients and papillary carcinoma patients, is caused by autoantibodies specific for the extracellular domain of the c-RET ..
  40. SIGNALING CROSSTALK AND THYROID CELL SURVIVAL
    Judy Meinkoth; Fiscal Year: 2002
    ..In Hashimoto's thyroiditis (HT), a specific immune response to thyroid antigens leads to lymphocytic infiltration, follicular cell ..
  41. Ret Signaling in Paraneoplastic Peripheral Neuropathy
    JOSEPHINE FOX; Fiscal Year: 2007
    ..applicant): This is a research plan to investigate whether peripheral neuropathy, observed in Hashimoto's thyroiditis patients and papillary carcinoma patients, is caused by autoantibodies specific for the extracellular domain of ..
  42. NOD-H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 2001
    DESCRIPTION (Taken from the Investigator's Abstract) Autoimmune thyroiditis is a multifactorial disease in which genetic predisposition combines with environmental factors to induce disease...
  43. SIGNALING CROSSTALK AND THYROID CELL SURVIVAL
    Judy Meinkoth; Fiscal Year: 2001
    ..In Hashimoto's thyroiditis (HT), a specific immune response to thyroid antigens leads to lymphocytic infiltration, follicular cell ..
  44. NOD H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 1999
    DESCRIPTION (Taken from the Investigator's Abstract) Autoimmune thyroiditis is a multifactorial disease in which genetic predisposition combines with environmental factors to induce disease...
  45. SIGNALING CROSSTALK AND THYROID CELL SURVIVAL
    Judy Meinkoth; Fiscal Year: 2003
    ..In Hashimoto's thyroiditis (HT), a specific immune response to thyroid antigens leads to lymphocytic infiltration, follicular cell ..
  46. NOD-H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 2000
    DESCRIPTION (Taken from the Investigator's Abstract) Autoimmune thyroiditis is a multifactorial disease in which genetic predisposition combines with environmental factors to induce disease...
  47. SIGNALING CROSSTALK AND THYROID CELL SURVIVAL
    Judy Meinkoth; Fiscal Year: 2000
    ..In Hashimoto's thyroiditis (HT), a specific immune response to thyroid antigens leads to lymphocytic infiltration, follicular cell ..
  48. PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
    LESLIE DEGROOT; Fiscal Year: 1993
    Autoimmune thyroid disease (Graves' disease, thyroiditis, myxedema) affects 6% of women during their life span...
  49. PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
    LESLIE DEGROOT; Fiscal Year: 1992
    Autoimmune thyroid disease (Graves' disease, thyroiditis, myxedema) affects 6% of women during their life span...
  50. PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
    LESLIE DEGROOT; Fiscal Year: 1991
    Autoimmune thyroid disease (Graves' disease, thyroiditis, myxedema) affects 6% of women during their life span...
  51. PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
    LESLIE DEGROOT; Fiscal Year: 1990
    Autoimmune thyroid disease (Graves' disease, thyroiditis, myxedema) affects 6% of women during their life span...
  52. CELLULAR AND GENETIC REGULATION OF AUTOIMMUNE DISEASE
    Helen Mullen; Fiscal Year: 1980
    ..the nature and mechanism of action of suppressor cells which regulate the induction of experimental autoimmune thyroiditis (EAT) in guinea pigs and 2) the basis for the genetic difference in susceptibility to EAT of Strain 2 and ..
  53. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 2000
    ..Adapted from the applicant's abstract): Canine models of human diseases have been used to study autoimmune thyroiditis, gluten-sensitive enteropathy, narcolepsy, complement deficiencies, and solid organ and hematopoietic ..
  54. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 1999
    ..Adapted from the applicant's abstract): Canine models of human diseases have been used to study autoimmune thyroiditis, gluten-sensitive enteropathy, narcolepsy, complement deficiencies, and solid organ and hematopoietic ..
  55. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 2001
    ..Adapted from the applicant's abstract): Canine models of human diseases have been used to study autoimmune thyroiditis, gluten-sensitive enteropathy, narcolepsy, complement deficiencies, and solid organ and hematopoietic ..
  56. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 1999
    ..Adapted from the applicant's abstract): Canine models of human diseases have been used to study autoimmune thyroiditis, gluten-sensitive enteropathy, narcolepsy, complement deficiencies, and solid organ and hematopoietic ..
  57. Mechanisms by which B cell depletion inhibits autoimmune diseases
    Helen Mullen; Fiscal Year: 2009
    ..is to determine how B cells regulate development of autoimmune diseases in a model of spontaneous autoimmune thyroiditis (SAT). All wild-type (WT) NOD.H-2h4 mice given 0...
  58. Mechanisms by which B cell depletion inhibits autoimmune diseases
    HELEN B MULLEN; Fiscal Year: 2010
    ..is to determine how B cells regulate development of autoimmune diseases in a model of spontaneous autoimmune thyroiditis (SAT). All wild-type (WT) NOD.H-2h4 mice given 0...
  59. ROLE OF THYROGLOBULIN IODINATION IN THYROIDITIS
    NANDALAL BAGCHI; Fiscal Year: 1992
    The broad objective of the proposed research is to study the mechanism by which iodine induces autoimmune thyroiditis in the susceptible animal and human population...
  60. AUTOIMMUNE THYROIDITIS: MECHANISMS OF INDUCTION
    Helen Mullen; Fiscal Year: 1990
    ..mechanisms involved in induction and regulation of autoimmunity using a murine model of experimental autoimmune thyroiditis (EAT)...
  61. AUTOIMMUNE THYROIDITIS: MECHANISMS OF INDUCTION
    Helen Mullen; Fiscal Year: 1991
    ..mechanisms involved in induction and regulation of autoimmunity using a murine model of experimental autoimmune thyroiditis (EAT)...
  62. ANTIGENS AND ANTIBODIES IN GRAVES' OPHTHALMOPATHY
    Jack Wall; Fiscal Year: 1992
    ..which may explain the association of the eye disorder with Graves' hyperthyroidism and, less often, Hashimoto's thyroiditis. Because autoantibodies reactive with the 64 kDa antigen also cross-react with a shared antigen in other ..
  63. ANTIGENS AND ANTIBODIES IN GRAVES' OPHTHALMOPATHY
    Jack Wall; Fiscal Year: 1991
    ..which may explain the association of the eye disorder with Graves' hyperthyroidism and, less often, Hashimoto's thyroiditis. Because autoantibodies reactive with the 64 kDa antigen also cross-react with a shared antigen in other ..