hyperthyroidism

Summary

Summary: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.

Top Publications

  1. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
  2. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
  3. ncbi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn Chair
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Thyroid 21:593-646. 2011
  4. ncbi Antithyroid drugs
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore 21215, USA
    N Engl J Med 352:905-17. 2005
  5. ncbi A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Eur J Endocrinol 165:491-7. 2011
  6. ncbi Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline
    LESLIE DE GROOT
    University of Rhode Island, Providence, Rhode Island 02881, USA
    J Clin Endocrinol Metab 97:2543-65. 2012
  7. ncbi Cardiovascular involvement in patients with different causes of hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Nat Rev Endocrinol 6:431-43. 2010
  8. ncbi Myocardial antioxidant enzyme activities and concentration and glutathione metabolism in experimental hyperthyroidism
    A S R Araujo
    Departamento Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Mol Cell Endocrinol 249:133-9. 2006
  9. pmc Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
    Tinh Hai Collet
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Arch Intern Med 172:799-809. 2012
  10. ncbi Thyroid hormone use, hyperthyroidism and mortality in older women
    Douglas C Bauer
    Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
    Am J Med 120:343-9. 2007

Research Grants

  1. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2002
  2. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2002
  3. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
  4. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
  5. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
  6. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
  7. Heart Vascular Function and Thyroid Hormone Receptors
    Wolfgang H Dillmann; Fiscal Year: 2013
  8. TSH RECEPTOR MULTIMERIZATION
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
  9. TSH and Bone
    Mone Zaidi; Fiscal Year: 2013
  10. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013

Detail Information

Publications374 found, 100 shown here

  1. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
    ..The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established...
  2. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
    ..Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age...
  3. ncbi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn Chair
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Thyroid 21:593-646. 2011
    ..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
  4. ncbi Antithyroid drugs
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore 21215, USA
    N Engl J Med 352:905-17. 2005
  5. ncbi A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Eur J Endocrinol 165:491-7. 2011
    Overt hyperthyroidism has been associated with cardiac arrhythmias, hypercoagulopathy, stroke, and pulmonary embolism, all of which may increase mortality...
  6. ncbi Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline
    LESLIE DE GROOT
    University of Rhode Island, Providence, Rhode Island 02881, USA
    J Clin Endocrinol Metab 97:2543-65. 2012
    ..A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at http://jcem.endojournals.org)...
  7. ncbi Cardiovascular involvement in patients with different causes of hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Nat Rev Endocrinol 6:431-43. 2010
    Various clinical disorders can cause hyperthyroidism, the effects of which vary according to the patient's age, severity of clinical presentation and association with other comorbidities...
  8. ncbi Myocardial antioxidant enzyme activities and concentration and glutathione metabolism in experimental hyperthyroidism
    A S R Araujo
    Departamento Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Mol Cell Endocrinol 249:133-9. 2006
    b>Hyperthyroidism was induced in rats by l-thyroxine administration (12 mg/L in drinking water, 4 weeks). Animals were assessed hemodynamically, and heart, lung, and liver morphometry were performed...
  9. pmc Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
    Tinh Hai Collet
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Arch Intern Med 172:799-809. 2012
    Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting...
  10. ncbi Thyroid hormone use, hyperthyroidism and mortality in older women
    Douglas C Bauer
    Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
    Am J Med 120:343-9. 2007
    ..The safety of thyroid hormone use and long-term prognosis of hyperthyroidism remain controversial...
  11. pmc Excess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a danish nationwide register-based cohort study of twins and singletons
    Frans Brandt
    Consultant Physician, Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 97:4123-9. 2012
    b>Hyperthyroidism is associated with severe comorbidity, such as stroke, and seems to confer increased mortality...
  12. ncbi Association of iodine fortification with incident use of antithyroid medication--a Danish Nationwide Study
    Charlotte Cerqueira
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    J Clin Endocrinol Metab 94:2400-5. 2009
    Iodine-induced hyperthyroidism has been reported in the early phases of almost all iodine fortification programs, depending on prior iodine intake in the population, the amount of fortification, and the rate of change.
  13. ncbi The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis
    Danka J F Stuijver
    Department of Internal Medicine, Slotervaart Hospital, Louwesweg, Amsterdam, The Netherlands
    Thromb Haemost 108:1077-88. 2012
    ..This was observed in endogenous and exogenous thyrotoxicosis, and in subclinical as well as overt hyperthyroidism. We conclude that both subclinical and overt hyperthyroidism induce a prothrombotic state, which is therefore ..
  14. ncbi Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II School of Medicine, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:968-74. 2002
  15. ncbi Insulin action in hyperthyroidism: a focus on muscle and adipose tissue
    Panayota Mitrou
    Hellenic National Center for Research, Prevention, and Treatment of Diabetes Mellitus and Its Complications, 10675 Athens, Greece
    Endocr Rev 31:663-79. 2010
    b>Hyperthyroidism leads to an enhanced demand for glucose, which is primarily provided by increased rates of hepatic glucose production due to increased gluconeogenesis (in the fasting state) and increased Cori cycle activity (in the late ..
  16. pmc Hyperthyroidism and risk for bipolar disorders: a nationwide population-based study
    Li Yu Hu
    Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
    PLoS ONE 8:e73057. 2013
    ..The most common clinical features associated with hyperthyroidism are anxiety and depression...
  17. ncbi Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 23:408-13. 2013
    b>Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear...
  18. ncbi Thyroid hormone and the cardiovascular system
    Sara Danzi
    Department of Biological Sciences and Geology, Queensborough Community College, Bayside, NY 11364, USA
    Med Clin North Am 96:257-68. 2012
    ..The characteristic changes in cardiovascular hemodynamics and metabolism that accompany thyroid disease states can then be best understood at the cellular level...
  19. ncbi Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart
    M Lopez-Torres
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040, Madrid, Spain
    Mol Cell Endocrinol 168:127-34. 2000
    ..05). Hyperthyroidism did not significantly change heart mitochondrial H(2)O(2) production since the increase in State 4 oxygen ..
  20. ncbi The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidism
    Thenmalar Vadiveloo
    Dundee Epidemiology and Biostatistics Unit, Division of Clinical and Population Sciences and Education, Mackenzie Building, Kirsty Semple Way, University of Dundee, Dundee, Scotland, DD2 4BF United Kingdom
    J Clin Endocrinol Metab 96:1344-51. 2011
    Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH).
  21. ncbi Thyroid cancer in patients with hyperthyroidism
    K Pazaitou-Panayiotou
    Department of Endocrinology Endocrine Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece
    Horm Metab Res 44:255-62. 2012
    ..The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects ..
  22. ncbi Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals
    Renate T de Jongh
    Department of Internal Medicine and Endocrinology EMGO Institute for Health and Care Research Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 165:545-54. 2011
    ..To what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate...
  23. ncbi Hyperthyroidism
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
    Lancet 362:459-68. 2003
    b>Hyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone...
  24. ncbi Vascular and renal function in experimental thyroid disorders
    Felix Vargas
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Granada, E 18012 Granada, Spain
    Eur J Endocrinol 154:197-212. 2006
    ..In hyperthyroidism, there is a resetting of the pressure-natriuresis relationship related to hyperactivity of the renin-..
  25. ncbi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA
    Endocr Pract 17:456-520. 2011
    ..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
  26. ncbi Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Clin Endocrinol (Oxf) 59:621-9. 2003
    ..The aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy...
  27. ncbi The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status
    Husamettin Erdamar
    Department of Medical Biochemistry, Tunceli Government Hospital, Tunceli, Turkey
    Clin Chem Lab Med 46:1004-10. 2008
    ..The aim of this study was to investigate the influence of hypothyroidism, hyperthyroidism, and their treatments on the metabolic state of oxidative stress, and antioxidant status markers.
  28. ncbi Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease
    Hirotoshi Nakamura
    Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
    J Clin Endocrinol Metab 92:2157-62. 2007
    Although methimazole (MMI) and propylthiouracil (PTU) have long been used to treat hyperthyroidism caused by Graves' disease (GD), there is still no clear conclusion about the choice of drug or appropriate initial doses.
  29. pmc Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study
    Graziano Ceresini
    Department of Geriatrics, Endocrine Unit, University of Parma, Italy
    J Am Geriatr Soc 57:89-93. 2009
    ..To investigate thyroid function testing abnormalities in older persons and to explore the relationship between thyroid dysfunction and cognition...
  30. ncbi Influence of iodine-131 dose on the outcome of hyperthyroidism in children
    Scott A Rivkees
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Pediatrics 111:745-9. 2003
    Iodine-131 is an effective treatment for Graves' hyperthyroidism in children and adults. Yet the responses to treatment as related to iodine-131 dose in children are not well-defined...
  31. ncbi Effect of experimental and cold exposure induced hyperthyroidism on H2O2 production and susceptibility to oxidative stress of rat liver mitochondria
    P Venditti
    Dipartimento delle Scienze Biologiche Sezione di Fisiologia, Universita di Napoli, I 80134 Napoli, Italy
    Arch Biochem Biophys 447:11-22. 2006
    ..However, a significant role is also played by T4, which appears to acts mainly modulating T3 effects, but also inducing some effects different from the T3 ones...
  32. ncbi Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    Eur J Endocrinol 170:341-8. 2014
    Thyroid hormones are essential for the normal development of the fetal brain, while hyperthyroidism in adults is associated with mood symptoms and reduced quality of life...
  33. ncbi Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism
    Connie M Rhee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 172:153-9. 2012
    ..Despite compelling biological plausibility and clinical implication, the association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism has not been rigorously studied.
  34. pmc Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e66711. 2013
    b>Hyperthyroidism has been linked with different morbidities, like atrial fibrillation, stroke and diabetes mellitus...
  35. ncbi Lower urinary tract symptoms and urinary flow rates in female patients with hyperthyroidism
    Chen Hsun Ho
    Division of Urology, Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Urology 77:50-4. 2011
    To investigate lower urinary tract symptoms (LUTS) and voiding function in a cohort of hyperthyroid women. The autonomic nervous system (ANS) imbalance has been thought to cause LUTS in hyperthyroidism.
  36. pmc Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 153:2919-28. 2012
    ..Comparison of the effects on gene expression observed in D3 deficiency with those in hypothyroidism, hyperthyroidism, and type 2 deiodinase (D2) deficiency revealed that the negative genes are more sensitive to D2 and D3 ..
  37. ncbi Increased risk of hypothyroidism and hyperthyroidism in patients with major depressive disorder: a population-based study
    En Liang Wu
    Taoyuan Mental Hospital, Department of Health, Taoyuan, Taiwan
    J Psychosom Res 74:233-7. 2013
    To determine the prevalence and incidence of hypothyroidism, hyperthyroidism, and risk factors in patients with major depressive disorder (MDD).
  38. ncbi Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies
    Elizabeth O Johnson
    Department of Anatomy, School of Medicine, University of Athens, 75 Mikras Asias Str, 11527 Goudi, Athens, Greece
    Pituitary 16:275-86. 2013
    b>Hyperthyroidism is associated with hypercorticosteronemia, although the locus that is principally responsible for the hypercorticosteronism remains unclear...
  39. ncbi Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment
    Florentia Kaguelidou
    Institut National de la Santé et de la Recherche Médicale U690, Hopital Robert Debre, 75019 Paris, France
    J Clin Endocrinol Metab 93:3817-26. 2008
    ..There is debate about how Graves' disease (GD) should be treated in children...
  40. ncbi The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population
    Pernille Vejbjerg
    Department of Internal Medicine I, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Eur J Endocrinol 155:547-52. 2006
    ..The aim of this study was to investigate the association between echogenicity of the thyroid/irregular echo pattern, and thyroid function in the general population, i.e. subjects without overt thyroid disease...
  41. ncbi Blood coagulation and fibrinolysis in patients with hyperthyroidism
    C Erem
    Division of Endocrinology and Metabolism, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
    J Endocrinol Invest 25:345-50. 2002
    Several papers concerning abnormalities of blood coagulation and fibrinolysis during hyperthyroidism, have been published. Increased von Willebrand Factor (vWF) activity and high fibrinogen levels have been reported...
  42. ncbi Effects of hyperthyroidism on lipid content and composition in oxidative and glycolytic muscles in rats
    A Miklosz
    Department of Physiology, Medical University of Bialystok, Poland
    J Physiol Pharmacol 63:403-10. 2012
    ..Consequently, we hypothesize that hyperthyroidism may influence intramuscular lipids accumulation...
  43. ncbi Relationship of subclinical thyroid disease to the incidence of gestational diabetes
    Carmen M Tudela
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Obstet Gynecol 119:983-8. 2012
    ..To estimate if there is a relationship between subclinical thyroid disease and gestational diabetes...
  44. ncbi Do worked examples foster medical students' diagnostic knowledge of hyperthyroidism?
    Veronika Kopp
    Institute for Teaching and Educational Research in Health Sciences, Private University of Witten Herdecke, Germany
    Med Educ 43:1210-7. 2009
    ..However, combining erroneous examples with knowledge of correct result (KCR) feedback impaired learning. This study was designed to establish whether these findings could be replicated in the domain of learning about hyperthyroidism.
  45. ncbi Increased pressor sensitivity to chronic nitric oxide deficiency in hyperthyroid rats
    Isabel Rodriguez-Gomez
    Departamento de Fisiologia, Facultad de Medicina, E 18012 Granada, Spain
    Hypertension 42:220-5. 2003
    ....
  46. ncbi Radiation dose to family members of hyperthyroidism and thyroid cancer patients treated with 131I
    G S Pant
    Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Radiat Prot Dosimetry 118:22-7. 2006
    ..0 mSv (mean 0.8 mSv). The thyroid monitoring was also done in 103 family members who attended the patients in isolation wards for >2 d. Thyroid dose in them ranged from 0 to 2.5 mGy (mean 0.1 mGy)...
  47. ncbi Subclinical hyperthyroidism and the risk of cardiovascular events and all-cause mortality: an updated meta-analysis of cohort studies
    Li Bo Yang
    Department of Endocrinology, Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan 250021, People s Republic of China
    Eur J Endocrinol 167:75-84. 2012
    Whether subclinical hyperthyroidism (SCH) results in poor prognosis remains controversial...
  48. ncbi Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease
    Chaoming Mao
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 186:4734-43. 2011
    ..Collectively, uGD-derived DCs through pDC polarization and elevated thyroid hormones act in concert to impair the regulatory capacity of Treg cells, facilitating the production of TSHR autoantibodies in the pathogenesis of GD...
  49. ncbi Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system
    O M Ahmed
    Physiology Division, Zoology Department, Faculty of Science, Beni Suef University, Beni Suef, Egypt
    Int J Dev Neurosci 30:517-37. 2012
    ..Thus, the objective of this study was to clarify the effect of hypothyroidism and hyperthyroidism in rat dams on the neurons development of different brain regions of their offspring at several postnatal ..
  50. ncbi Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition
    Gerasimos E Krassas
    Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
    Eur J Endocrinol 153:217-21. 2005
    ..To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results...
  51. ncbi Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart
    Lisa C Heather
    Department of Physiology, Anatomy, and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom
    Endocrinology 151:422-31. 2010
    ..Here we determined the effect of hyperthyroidism on substrate metabolism in the isolated, perfused, contracting rat heart...
  52. ncbi Mechanisms in endocrinology: Heart failure and thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Italy
    Eur J Endocrinol 167:609-18. 2012
    ..The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction...
  53. ncbi The utility of radioiodine uptake and thyroid scintigraphy in the diagnosis and management of hyperthyroidism
    O E Okosieme
    Department of Endocrinology and Diabetes, Prince Charles Hospital, Cwm Taff NHS Trust, Merthyr Tydfil, Mid Glamorgan
    Clin Endocrinol (Oxf) 72:122-7. 2010
    The value and practice of thyroid radionuclide imaging in the diagnosis and management of hyperthyroidism is unsettled...
  54. ncbi Oxidative stress in heart tissue of hyperthyroid and iron supplemented rats
    S Civelek
    Department of Biochemistry, Cerrahpasa Medical Facility, Istanbul University, Turkey
    J Toxicol Environ Health A 64:499-506. 2001
    This study was designed to investigate the effect of hyperthyroidism and/or iron supplementation or cardiac oxidative stress parameters--the lipid peroxidation end product glutathione (GSH), glutathione peroxidase (CSH-Px), and ..
  55. ncbi Overt hyperthyroidism and hypothyroidism during pregnancy
    Alex Stagnaro-Green
    George Washington University School of Medicine and Health Sciences, Washington, DC, USA
    Clin Obstet Gynecol 54:478-87. 2011
    ..manuscript provides a definition for, and evaluates the prevalence and maternal/fetal/child impact of, overt hyperthyroidism and overt hypothyroidism. The prevalence of overt hyperthyroidism is 0...
  56. ncbi Effects of hypothyroidism induced by 6-n-propylthiouracil and its reversal by T3 on rat heart superoxide dismutase, catalase and lipid peroxidation
    S Chattopadhyay
    Department of Biotechnology, Utkal University, Bhubaneswar 751004, India
    Indian J Exp Biol 41:846-9. 2003
    ..b>Hyperthyroidism registered increased SOD activity in post-mitochondrial fraction...
  57. ncbi Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aahus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:411-9. 2002
    To study fracture risk in patients with hyperthyroidism and hypothyroidism.
  58. ncbi Redox regulation of myocardial ERK 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin system
    Alex Sander da Rosa Araujo
    Department of Physiology, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cardiovasc Pharmacol 56:513-7. 2010
    ..adaptation in the antioxidant system would differentially modulate prosurvival and proapoptotic proteins in hyperthyroidism-induced cardiac hypertrophy...
  59. ncbi Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunction
    Subhashini Yaturu
    Department of Endocrinology, VAMC LSU HSC, Shreveport, Louisiana 71101 4295, USA
    J Cell Biochem 93:491-6. 2004
    ..and leptin in 69 subjects with Graves' disease before and 32 patients at follow up after treatment for hyperthyroidism at hypothyroid state...
  60. ncbi Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumors
    S F Oosting
    Department of Medical Oncology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Ann Oncol 21:104-8. 2010
    Patients with elevated human chorionic gonadotrophin (HCG) can have hyperthyroidism. We assessed the prevalence of hyperthyroidism in patients presenting with disseminated non-seminomatous germ-cell tumors (NSGCT).
  61. ncbi Iodine-induced hyperthyroidism--an epidemiological survey several years after institution of iodine prophylaxis in Poland
    A Lewinski
    Department of Thyroidology, Medical University of Lodz, Poland
    J Endocrinol Invest 26:57-62. 2003
    ..In order to monitor possible side-effects of increased iodine supply, studies on iodine-induced hyperthyroidism were initiated by establishing several regional registers of hyperthyroidism...
  62. ncbi High serum osteoprotegerin levels in patients with hyperthyroidism: effect of medical treatment
    G Amato
    Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, 80121, Naples, Italy
    Bone 35:785-91. 2004
    This study was aimed at evaluating serum osteoprotegerin (OPG) concentrations in a cohort of patients with hyperthyroidism before and after methimazole (MMI) treatment...
  63. ncbi Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidism
    Aziz Yazar
    Department of Internal Medicine, Mersin University Medical School, Mersin, Turkey
    Arch Med Res 34:35-40. 2003
    The aim of this study was to investigate systolic pulmonary artery pressure (SPAP) and serum uric acid (SUA) levels in patients with hyperthyroidism and after euthyroid state was reached.
  64. ncbi Thyroid status and nitric oxide in rat arterial vessels
    R M McAllister
    Department of Anatomy and Physiology and Kinesiology, Kansas State University, Manhattan, Kansas 66506, USA
    J Endocrinol 185:111-9. 2005
    Thyroid disease has profound effects on cardiovascular function. Hypo- and hyperthyroidism, for example, are associated with reduced and increased maximal endothelium-dependent vasodilation respectively...
  65. ncbi Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy
    Laura Elbers
    Department of Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 21:279-83. 2011
    It is still debated which treatment modality for Graves' hyperthyroidism (GH) is most appropriate when Graves' orbitopathy (GO) is present...
  66. ncbi Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism
    Wei Jan Chen
    First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Fu Shin Road no 5, Kwei Shan, Tao Yuan, Taiwan
    Basic Res Cardiol 106:163-74. 2011
    Atrial fibrillation (AF) is a common complication in hyperthyroidism. Earlier studies demonstrate that thyroid hormone decreases L-type calcium channel (LCC) current expression with resultant shortening of action potential duration (APD),..
  67. ncbi Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathway
    Murat Giris
    Department of Biochemistry, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    J Surg Res 164:266-75. 2010
    The exact pathogenesis of hepatic dysfunction in hyperthyroidism is still unknown...
  68. ncbi Experimental hyperthyroidism-induced oxidative stress and impairment of antioxidant defence system in rat testis
    Dipak K Sahoo
    Department of Biotechnology, Utkal University, Bhubaneswar 7510 04, India
    Indian J Exp Biol 43:1058-67. 2005
    Short-term hyperthyroidism, induced by daily administration of T3 (20 microg/100g body weight) for one, three, and five days consecutively, modulates oxidative stress and antioxidant defence parameters in mitochondrial and ..
  69. ncbi CD8+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model
    Ohki Saitoh
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, Japan
    Endocrinology 148:6040-6. 2007
    ..antibody mediated depletion of CD4(+)CD25(+) regulatory T cells (Tregs) enhances incidence and severity of hyperthyroidism in resistant and susceptible mouse strains, respectively...
  70. ncbi Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat
    V Fernandez
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago
    Nitric Oxide 1:463-8. 1997
    b>Hyperthyroidism enhances the prooxidant activity of the liver by elevating superoxide radical and/or hydrogen peroxide generation in microsomal, mitochondrial, and peroxisomal fractions, with an increased respiratory burst of Kupffer ..
  71. ncbi Color flow Doppler sonography for the etiologic diagnosis of hyperthyroidism
    Murat Faik Erdogan
    Ankara University, Medical School, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey
    Thyroid 17:223-8. 2007
    ..We aimed to determine the value of CFDS for the etiological diagnosis of hyperthyroidism. Fifty-five patients with hyperthyroidism (29 Graves' disease [GD] and 26 toxic adenoma [TA]), 24 patients ..
  72. pmc Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor
    P Kopp
    Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Invest 100:1634-9. 1997
    ..cause of hyperfunctioning thyroid adenomas, and germline mutations have been found in familial nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism...
  73. ncbi Safety and efficacy of surgical management of hyperthyroidism: 15-year experience from a tertiary care center in a developing country
    P V Pradeep
    Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareillei Road, Lucknow, Uttar Pradesh, 226014, India
    World J Surg 31:306-12; discussion 313. 2007
    ..In this paper, we discuss the experience of the surgical management of hyperthyroidism at a specialized tertiary care endocrine center in a developing country, highlighting the minimal morbidity ..
  74. ncbi QTc dispersion in hyperthyroidism and its association with pulmonary hypertension
    Unal Guntekin
    Yuzuncu Yil University, Faculty of Medicine, Cardiology Department, Van, Turkey
    Pacing Clin Electrophysiol 32:494-9. 2009
    Several studies have reported that hyperthyroidism is associated with prolonged QT interval corrected by the heart rate (QTc) and pulmonary hypertension (PHT).
  75. pmc Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study
    M Hatch
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Rockville, Maryland 20852, USA
    Radiat Res 174:763-72. 2010
    Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels...
  76. ncbi Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism
    K Boelaert
    Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 70:129-38. 2009
    There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism.
  77. ncbi Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Maturitas 48:299-306. 2004
    Although overt hyperthyroidism is a well known cause of bone loss, systemic effects of subclinical hyperthyroidism (SH) are still a matter of debate.
  78. ncbi Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China
    Fan Yang
    Department of Endocrinology and Metabolism, First Affiliated Hospital, China Medical University, No 155 Nanjing Bei St, Heping District, Shenyang, China
    Eur J Endocrinol 156:403-8. 2007
    An increasing incidence of hyperthyroidism has been observed when iodine supplementation has been introduced to an iodine-deficient population...
  79. ncbi Severe acute renal failure due to tubulointerstitial nephritis, pancreatitis, and hyperthyroidism in a patient during rifampicin therapy
    Saime Paydas
    Department of Nephrology, Cukurova University School of Medicine, Balcali, Adana, Turkey
    Adv Ther 22:241-3. 2005
    It is well known that rifampicin can cause nephrotoxicity. Rifampicin-related pancreatitis and hyperthyroidism are rarely reported in the same patient in the presence of tubulointerstitial nephritis...
  80. pmc Hyperthyroidism--cause of depression and psychosis: a case report
    G Marian
    UMF Carol Davila, Clinical Hospital Prof Dr AI Obregia, Bucharest, Romania
    J Med Life 2:440-2. 2009
    ..Psychotic symptoms in the context of hyperthyroidism typically present as an affective psychosis...
  81. ncbi Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specific
    K Ojamaa
    Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
    Endocrinology 140:3170-6. 1999
    ..5 mRNA (6.10+/-0.37x10(-20) mol/microg RNA) was unaltered by thyroid hormone status. The myocyte-specific and chamber-selective expression of Kv1.5 mRNA was confirmed in primary cultures of rat atrial and ventricular myocytes...
  82. ncbi Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study
    Allan Carlé
    Department of Endocrinology and Internal Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Eur J Endocrinol 164:801-9. 2011
    Few population-based studies have described the epidemiology of subtypes of hyperthyroidism.
  83. pmc Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)
    Isabela M Bensenor
    Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    BMC Public Health 10:298. 2010
    Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people
  84. ncbi Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice
    Yumiko Mizutori
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Autoimmun 26:32-6. 2006
    ..injected with dendritic cells (DCs) infected with adenovirus encoding the full-length TSHR (AdTSHR) develop hyperthyroidism, albeit at a low incidence (36%)...
  85. ncbi Insulin resistance in hyperthyroidism: the role of IL6 and TNF alpha
    Panayota Mitrou
    Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
    Eur J Endocrinol 162:121-6. 2010
    Although insulin resistance is a common finding in hyperthyroidism, the implicated mechanisms are obscure...
  86. ncbi Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients
    B Biondi
    Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
    J Clin Endocrinol Metab 85:4701-5. 2000
    To determine the clinical impact of endogenous subclinical hyperthyroidism, specific symptoms and signs of thyroid hormone excess and quality of life were assessed in 23 patients (3 males and 20 females; mean age, 43 +/- 9 yr) and 23 age-..
  87. ncbi Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism
    Eirini Maratou
    Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
    Eur J Endocrinol 163:625-30. 2010
    Although clinical hyperthyroidism (HR) is associated with insulin resistance, the information on insulin action in subclinical hyperthyroidism (SHR) is limited.
  88. ncbi Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort study
    Henry Volzke
    SHIP Clinical Epidemiological Research Unit, Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Eur J Endocrinol 161:615-21. 2009
    There is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet...
  89. ncbi Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism
    Alev E Altinova
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
    Clin Endocrinol (Oxf) 65:530-5. 2006
    ..The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction...
  90. ncbi Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism
    C Rochon
    Unité de Nutrition et Métabolisme Protéique, INRA Centre de Clermont Ferrand, 63122 Saint Genes Champanelle, France
    Clin Sci (Lond) 104:7-15. 2003
    ..thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps...
  91. ncbi Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations
    A Hebrant
    School of Medicine, Institute of Interdisciplinary Research IRIBHM, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
    Eur J Endocrinol 164:1-9. 2011
    Three syndromes affecting the thyroid gland are described in the literature separately: familial nonautoimmune hyperthyroidism, sporadic congenital nonautoimmune hyperthyroidism, and autonomous adenomas...
  92. ncbi The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism
    A S R Araujo
    Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050 170 Porto Alegre, RS, Brazil
    J Mol Endocrinol 41:423-30. 2008
    ..protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were divided into four groups: control, vitamin E, thyroxine (T(4)), and T(4)+vitamin E...
  93. ncbi Subclinical hyperthyroidism and pregnancy outcomes
    Brian M Casey
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Obstet Gynecol 107:337-41. 2006
    Subclinical hyperthyroidism has long-term sequelae that include osteoporosis, cardiovascular morbidity, and progression to overt thyrotoxicosis or thyroid failure...
  94. ncbi Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnover
    Kamal A S Al-Shoumer
    Division of Endocrinology and Metabolic Medicine, Mubarak Al Kabeer Hospital, Jabriya, and the Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Endocr Pract 12:121-30. 2006
    To study glucose and bone metabolism in hyperthyroidism, assess their changes after treatment, and investigate their interrelationships.
  95. ncbi Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism
    L Duprez
    Institut de Recherche Interdisciplinaire, Faculty of Medicine, University of Brussels, Belgium
    Nat Genet 7:396-401. 1994
    ..mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) ..
  96. ncbi Increased risk of hyperthyroidism among patients hospitalized with bipolar disorder
    Anders F Thomsen
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Bipolar Disord 7:351-7. 2005
    b>Hyperthyroidism has been associated with affective disorder in many cross-sectional studies, but longitudinal studies in this connection are scarce...
  97. ncbi The association of thyroid function with cardiac mass and left ventricular hypertrophy
    Marcus Dorr
    Department of Internal Medicine B, Ernst Moritz Arndt University, Friedrich Loeffler Strasse 23a, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 90:673-7. 2005
    ..Overt hyperthyroidism was associated with LVMI (P < 0...
  98. ncbi Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidism
    Ayse S Cikim
    Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Inonu University, Malatya, Turkey
    Thyroid 14:605-9. 2004
    Subclinical hypothyroidism and subclinical hyperthyroidism are two frequently occurring conditions for which exact therapeutic approaches have not yet been established...
  99. ncbi Depression and anxiety in hyperthyroidism
    Mehmet Murat Demet
    Department of Psychiatry, Department of Internal Medicine, Medical Faculty, Celal Bayar University, Manisa, Turkey
    Arch Med Res 33:552-6. 2002
    Our objective was to determine symptomatology of depression and anxiety in patients with untreated hyperthyroidism and compare with euthyroid patients.
  100. ncbi Increased cardiovascular and cancer mortality after radioiodine treatment for hyperthyroidism
    Saara Metso
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Clin Endocrinol Metab 92:2190-6. 2007
    Patients treated with radioiodine (RAI) for hyperthyroidism have been reported to be at increased risk for death. It is not clear whether the increased mortality is due to hyperthyroidism itself or the effect of RAI.
  101. ncbi Increased risk of affective disorder following hospitalisation with hyperthyroidism - a register-based study
    Anders F Thomsen
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Denmark
    Eur J Endocrinol 152:535-43. 2005
    ..We assessed whether hospitalisation with hyperthyroidism was a risk factor for hospitalisation with affective disorder and evaluated the temporal relationship between ..

Research Grants63

  1. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2002
    ..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
  2. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2002
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  3. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graves'disease (GD) accounts for the vast majority of cases of hyperthyroidism in young adults...
  4. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
  5. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The large majority of older patients with autoimmune Graves'hyperthyroidism and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 ..
  6. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
  7. Heart Vascular Function and Thyroid Hormone Receptors
    Wolfgang H Dillmann; Fiscal Year: 2013
    ..b>Hyperthyroidism increases coronary perfusion and enhances cardiac capillary density but these beneficial vascular effects are ..
  8. TSH RECEPTOR MULTIMERIZATION
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
    ..The TSHR is also the major autoantigen in the autoimmune hyperthyroidism known as Graves'disease where T cells and autoantibodies are directed at the TSHR...
  9. TSH and Bone
    Mone Zaidi; Fiscal Year: 2013
    ..potent anti-resorptive and anabolic actions, and that a loss of these actions contributes to the bone loss of hyperthyroidism. We will use genetically modified mice and state-of-the-art molecular approaches to understand the role of ..
  10. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013
    ..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
  11. THE THYROTHROPIN RECEPTOR IN HEALTH AND DISEASE
    Basil Rapoport; Fiscal Year: 2013
    ..In Graves'Disease thyroid-stimulating autoantibodies (TSAb) activate the TSHR and cause hyperthyroidism. Understanding how TSAb and TSH interact with the TSHR extracellular domain and how the TSHR structure ..
  12. Energy Balance and Neurodegenerative Disease
    Robert G Kalb; Fiscal Year: 2013
    ..This can not be attributed to poor nutrition, hyperthyroidism, fever, excessive motor activity or excessive brown fat activity...
  13. Quantitating Mitophagy in Skeletal Muscle Models
    Edgar A Arriaga; Fiscal Year: 2013
    ..is to apply these bioanalytical approaches to characterize the role of mitophagy in human conditions such as hyperthyroidism and aging that are characterized by alterations in protein turnover...
  14. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ..liver coupled with the demonstration that circulating atriopeptin concentrations are elevated in diabetes and hyperthyroidism (conditions associated with elevated gluconeogenic rats), and decreased under conditions when gluconeogenic ..
  15. Thyrotropin Receptor Autoantibodies in Graves'Ophthalmopathy
    Rebecca S Bahn; Fiscal Year: 2012
    ..to the prevention and treatment of Graves'ophthalmopathy (GO), the ocular disease linked to Graves' hyperthyroidism. Histopathologic changes within the GO orbit are striking and include accumulation of hyaluronic acid (HA) ..
  16. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    ..sulfur containing antithyroid drug, induces ANA in over 1/3 of hyperthyroid cats receiving 15mg/day for hyperthyroidism. However, this drug has failed to produce any clinical signs of a lupus-like syndrome...
  17. BEHAVIOR & HYPERTHYROIDISM: A BETA-ADRENERGIC MECHANISM?
    Paula Trzepacz; Fiscal Year: 1991
    We propose to investigate in Graves' disease, the most common type of hyperthyroidism. Our preliminary study used a higher degree of standardization and comprehensiveness than did previous studies...
  18. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
  19. ROLE OF THYROID HORMONE IN BROWN ADIPOSE TISSUE FUNCTION
    Jorge Silva; Fiscal Year: 1991
    ..the local mechanisms which can provide sufficient T3 to allow a full thermogenic response without systemic hyperthyroidism. The central question is whether the saturation of T3 receptors during adrenergic stimulation results from ..
  20. CONTROL OF MYOSIN TYPES IN INDIVIDUAL MUSCLE FIBERS
    Neal Rubinstein; Fiscal Year: 1993
    ..or symptomotology of muscle diseases such as floppy infant syndrome, respiratory muscle fatigue, or hypo- and hyperthyroidism. Our long term goal is to define the factors controlling expression of MHC isoforms and to investigate hoe ..
  21. B-ADRENERGIC RECEPTOR ACTIVATION AND EXPRESSION
    CURTIS MACHIDA; Fiscal Year: 1993
    ..roles in cardiovascular diseases, such as cardiac hypertrophy and hypertesnion, in bronchial asthma, and in hyperthyroidism. While much is known about the physiological responses of beeta- adrenergic receptors to catecholamines, our ..
  22. Mentored Patient-Oriented Research Career Development Aw
    Zhenqi Liu; Fiscal Year: 2004
    DESCRIPTION (Adapted from the applicant's abstract): Many disease states, including glucocorticoid excess and hyperthyroidism, are associated with accelerated protein catabolism, causing chronic muscle wasting and increasing morbidity ..
  23. SKELETAL MUSCLE ADRENERGIC RECEPTOR PATHOPHYSIOLOGY
    Wade Martin; Fiscal Year: 1993
    ..and older humans, 2) to characterize effects of endurance exercise- training, beta-blockade, chronic CHF, and hyperthyroidism on adrenergic receptor density and distribution and myocyte fiber type population, 3) to determine whether ..
  24. THYROID STATUS VASCULAR AND OTHER SMOOTH MUSCLE FUNCTION
    JOSEPH OLUBADEWO; Fiscal Year: 1993
    ..increased plasma LDL cholesterol and atherosclerotic cardiac disease, whereas the opposite is observed for hyperthyroidism. Therefore we propose to produce altered lipoprotein metabolism in rats by inducing hypo- and hyperthyroidism...
  25. Deiodinases in Thyroid Hormone Homeostasis
    ANN ZAVACKI; Fiscal Year: 2006
    ..despite seemingly normal T3 levels, at least one peripheral marker of thyroid status, D1 activity, suggests hyperthyroidism in the latter two mouse models...
  26. TSH Receptor Antibody Heterogeneity in Graves' Disease
    Jessica Smith; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Graves' disease, the most common form of hyperthyroidism in children, is caused by Thyrotropin (TSH) Receptor Antibodies (TRAbs) that mimic the action of TSH...
  27. The Genetic Basis of Atrial Fibrillation
    Dawood Darbar; Fiscal Year: 2009
    ..Most AF is considered secondary to other conditions such as hypertension, hyperthyroidism, cardiomyopathy or valvular disease;however, a substantial minority of patients without obvious cause are ..
  28. REGULATORY MECHANISMS IN ENERGY METABOLISM
    Robert Harris; Fiscal Year: 1992
    ..effects of acute glucagon treatment on energy transduction by liver mitochondria; (c) the nature of hypo- and hyperthyroidism on mitochondrial bioenergetics; (d) liver mitochondria from hypercholesterolemia animals and from hepatomas ..
  29. THYROID GLAND PHYSIOLOGY IN HEALTH AND DISEASE
    INDER CHOPRA; Fiscal Year: 1990
    ..We shall also investigate that usefulness of iodinated radio-contrast agents, e.g. sodium ipodate, a potent inhibitor of extrathyroidal conversion of T4 to more active T3, in the management of hyperthyroidism.
  30. Hyperthermia: Uncoupling the agony from Ecstasy
    JON SPRAGUE; Fiscal Year: 2007
    ..will lead to improved targeted therapies for treatment of heat-related illnesses such as pheochromocytoma and hyperthyroidism. Over the past decade, the number of emergency room visits associated with stimulant abuse such as Ecstasy ..
  31. REGULATION OF CALCIUM CURRENTS IN DROSOPHILA
    Satpal Singh; Fiscal Year: 1999
    ..and heterologous factors and in several diseases like hypertension, myocardial ischemia, cardiomyopathy, hyperthyroidism, Lambert-Eaton syndrome and Parkinson's disease...
  32. CARDIAC ATROPHY--STUDIES IN THE TRANSPLANTED HEART
    Irwin Klein; Fiscal Year: 1990
    Cardiac work is the major determinant of cardiac size. Conditions such as hypertension, aortic stenosis, and hyperthyroidism increase the work of the myocardium and lead to the development of hypertrophy...
  33. MEMBRANOGENESIS IN CRETINISM AND HYPERTHYROIDISM
    Paola Timiras; Fiscal Year: 1980
    ....
  34. GRAVES' DISEASE STUDIES
    David Solomon; Fiscal Year: 1980
    ..as susceptible patients are developing hyperthyroidism, as patients under antithyroid drug treatment are becoming normally regulable and as such patients are ..
  35. An Animal Model for Graves'Disease/Ophthalmology
    Juan Jaume; Fiscal Year: 2005
    ..Graves' disease primarily manifests with hyperthyroidism that results from the stimulation of the TSHR by specific autoantibodies that mimic the effect of TSH...
  36. DISORDERS OF IMMUNE REGULATION
    J Streilein; Fiscal Year: 1990
    ..Four human diseases have been singled out: Hyperthyroidism (Graves' Disease); Insulin Dependent Diabetes Mellitus (Juvenile type); Pneumocystis carinii pulmonary ..
  37. THYROID ACTION IN THE HEART
    Wolfgang Dillmann; Fiscal Year: 2006
    ..In addition the mechanisms underlying hyperthyroidism induced atrial fibrillation will be determined.
  38. FUNCTIONAL ROLE OF MULTIPLE THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1991
    ..This research is relevant to the diagnosis and treatment of both hypothyroidism and hyperthyroidism. It is relevant to understanding the role of thyroid hormones in brain development.
  39. Selective Modulation of Thyroid Receptor Action
    John Baxter; Fiscal Year: 2007
    ..It is desirable to block TH in hyperthyroidism, but current blockade by inhibiting TH production is slow in onset...
  40. MECHANISMS OF ANESTHETIC-INDUCED MYOCARDIAL DEPRESSION
    JUDY SU; Fiscal Year: 1991
    ..long-term goal is to study the mechanisms of action of anesthetics and anesthesia-related drugs on cardiac muscle from other diseased states, such as hypertension, hyperthyroidism, diabetes, malnutrition, and skeletal muscle myopathies.
  41. REGULATION OF HEPATIC PRODUCTION OF HDL
    Henry Wilcox; Fiscal Year: 1980
    ..which reduce VLDL production which we will examine include the fasting state, experimental diabetes, and hyperthyroidism. Since the HDL levels are higher in females, associated with a lower risk of heart disease than for males, we ..
  42. RATIONAL DEVELOPMENT OF THYROID RECEPTOR ANTAGONISTS
    Matthieu Schapira; Fiscal Year: 2000
    ..Approximately 0.5 percent to 1 percent of women will experience clinical manifestations of hyperthyroidism sometime during their lifetime, and a significant number of cases occur in the elderly with potentially life ..
  43. TSH Hypersecretion in WKY: Positional Candidate Analysis
    Amber Baum; Fiscal Year: 2003
    The high comorbidity between hypo- and hyperthyroidism and depressive disorders illustrates the influence of hypothalamic-pituitary-thyroid (HPT) axis function on behavior...
  44. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  45. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism.
  46. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  47. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  48. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  49. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  50. EYE IN GRAVES DISEASE--ROLE OF ORBITAL FIBROBLASTS
    Rebecca Bahn; Fiscal Year: 2004
    ..because its involvement would help to explain the close clinical and laboratory associations between GO and hyperthyroidism. In recent studies, the PI has demonstrated the present of TSHr mRNA and protein in orbital adipose/..
  51. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  52. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  53. Thyrotropin Receptor Auto Antibodies in Graves' Ophthalmopathy
    Rebecca S Bahn; Fiscal Year: 2010
    ..Our studies will yield information concerning mechanisms involved in disease development, and will determine the effectiveness of a novel approach to therapy. ..
  54. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  55. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  57. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005
    ..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..