Genomes and Genes
Summary: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Publications337 found, 100 shown here
- Thyroid function and mortality in patients treated for hyperthyroidismJayne A Franklyn
Division of Medical Sciences, University of Birmingham, England
JAMA 294:71-80. 2005b>Hyperthyroidism has been reported to cause excess all-cause and circulatory mortality. Whether this can be reversed is unknown, as is the influence of mild persisting thyroid dysfunction and treatment-induced hypothyroidism.
- Serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid functionChing Jung Hsieh
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Endocr J 55:489-94. 2008..The aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication...
- The clinical significance of subclinical thyroid dysfunctionBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Endocr Rev 29:76-131. 2008..Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age...
- Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical EndocrinologistsRebecca S Bahn Chair
Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
Thyroid 21:593-646. 2011..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
- Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guidelineLESLIE DE GROOT
University of Rhode Island, Providence, Rhode Island 02881, USA
J Clin Endocrinol Metab 97:2543-65. 2012..A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at http://jcem.endojournals.org)...
- Cardiovascular involvement in patients with different causes of hyperthyroidismBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Nat Rev Endocrinol 6:431-43. 2010Various clinical disorders can cause hyperthyroidism, the effects of which vary according to the patient's age, severity of clinical presentation and association with other comorbidities...
- Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' diseaseChaoming Mao
Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
J Immunol 186:4734-43. 2011..Collectively, uGD-derived DCs through pDC polarization and elevated thyroid hormones act in concert to impair the regulatory capacity of Treg cells, facilitating the production of TSHR autoantibodies in the pathogenesis of GD...
- Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical EndocrinologistsRebecca S Bahn
Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA
Endocr Pract 17:456-520. 2011..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
- HyperthyroidismDavid S Cooper
Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
Lancet 362:459-68. 2003b>Hyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone...
- Myocardial antioxidant enzyme activities and concentration and glutathione metabolism in experimental hyperthyroidismA S R Araujo
Departamento Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Mol Cell Endocrinol 249:133-9. 2006b>Hyperthyroidism was induced in rats by l-thyroxine administration (12 mg/L in drinking water, 4 weeks). Animals were assessed hemodynamically, and heart, lung, and liver morphometry were performed...
- Subclinical hyperthyroidism and the risk of coronary heart disease and mortalityTinh Hai Collet
Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
Arch Intern Med 172:799-809. 2012Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting...
- Thyroid cancer in patients with hyperthyroidismK Pazaitou-Panayiotou
Department of Endocrinology Endocrine Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece
Horm Metab Res 44:255-62. 2012..The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects ..
- Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body compositionGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Eur J Endocrinol 153:217-21. 2005..To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results...
- Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individualsRenate T de Jongh
Department of Internal Medicine and Endocrinology EMGO Institute for Health and Care Research Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Eur J Endocrinol 165:545-54. 2011..To what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate...
- Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heartM Lopez-Torres
Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040, Madrid, Spain
Mol Cell Endocrinol 168:127-34. 2000..05). Hyperthyroidism did not significantly change heart mitochondrial H(2)O(2) production since the increase in State 4 oxygen ..
- The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidismThenmalar Vadiveloo
Dundee Epidemiology and Biostatistics Unit, Division of Clinical and Population Sciences and Education, Mackenzie Building, Kirsty Semple Way, University of Dundee, Dundee, Scotland, DD2 4BF United Kingdom
J Clin Endocrinol Metab 96:1344-51. 2011Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH).
- Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' diseaseHirotoshi Nakamura
Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
J Clin Endocrinol Metab 92:2157-62. 2007Although methimazole (MMI) and propylthiouracil (PTU) have long been used to treat hyperthyroidism caused by Graves' disease (GD), there is still no clear conclusion about the choice of drug or appropriate initial doses.
- Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti studyGraziano Ceresini
Department of Geriatrics, Endocrine Unit, University of Parma, Italy
J Am Geriatr Soc 57:89-93. 2009..To investigate thyroid function testing abnormalities in older persons and to explore the relationship between thyroid dysfunction and cognition...
- Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid functionPedro Iglesias
Department of Endocrinology, Hospital General, Segovia, Spain
Clin Endocrinol (Oxf) 59:621-9. 2003..The aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy...
- Influence of iodine-131 dose on the outcome of hyperthyroidism in childrenScott A Rivkees
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
Pediatrics 111:745-9. 2003Iodine-131 is an effective treatment for Graves' hyperthyroidism in children and adults. Yet the responses to treatment as related to iodine-131 dose in children are not well-defined...
- Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatmentFlorentia Kaguelidou
Institut National de la Santé et de la Recherche Médicale U690, Hopital Robert Debre, 75019 Paris, France
J Clin Endocrinol Metab 93:3817-26. 2008..There is debate about how Graves' disease (GD) should be treated in children...
- Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidismLuis Varela
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
J Pathol 227:209-22. 2012b>Hyperthyroidism is characterized in rats by increased energy expenditure and marked hyperphagia...
- Oxidative stress in heart tissue of hyperthyroid and iron supplemented ratsS Civelek
Department of Biochemistry, Cerrahpasa Medical Facility, Istanbul University, Turkey
J Toxicol Environ Health A 64:499-506. 2001This study was designed to investigate the effect of hyperthyroidism and/or iron supplementation or cardiac oxidative stress parameters--the lipid peroxidation end product glutathione (GSH), glutathione peroxidase (CSH-Px), and ..
- The utility of radioiodine uptake and thyroid scintigraphy in the diagnosis and management of hyperthyroidismO E Okosieme
Department of Endocrinology and Diabetes, Prince Charles Hospital, Cwm Taff NHS Trust, Merthyr Tydfil, Mid Glamorgan
Clin Endocrinol (Oxf) 72:122-7. 2010The value and practice of thyroid radionuclide imaging in the diagnosis and management of hyperthyroidism is unsettled...
- A critical review and meta-analysis of the association between overt hyperthyroidism and mortalityFrans Brandt
Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
Eur J Endocrinol 165:491-7. 2011Overt hyperthyroidism has been associated with cardiac arrhythmias, hypercoagulopathy, stroke, and pulmonary embolism, all of which may increase mortality...
- Effects of hypothyroidism induced by 6-n-propylthiouracil and its reversal by T3 on rat heart superoxide dismutase, catalase and lipid peroxidationS Chattopadhyay
Department of Biotechnology, Utkal University, Bhubaneswar 751004, India
Indian J Exp Biol 41:846-9. 2003..b>Hyperthyroidism registered increased SOD activity in post-mitochondrial fraction...
- Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patientsPeter Vestergaard
Department of Endocrinology and Metabolism C, Aahus Amtssygehus, Aarhus University Hospital, Denmark
Thyroid 12:411-9. 2002To study fracture risk in patients with hyperthyroidism and hypothyroidism.
- Redox regulation of myocardial ERK 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin systemAlex Sander da Rosa Araujo
Department of Physiology, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Cardiovasc Pharmacol 56:513-7. 2010..adaptation in the antioxidant system would differentially modulate prosurvival and proapoptotic proteins in hyperthyroidism-induced cardiac hypertrophy...
- Overt hyperthyroidism and hypothyroidism during pregnancyAlex Stagnaro-Green
George Washington University School of Medicine and Health Sciences, Washington, DC, USA
Clin Obstet Gynecol 54:478-87. 2011..manuscript provides a definition for, and evaluates the prevalence and maternal/fetal/child impact of, overt hyperthyroidism and overt hypothyroidism. The prevalence of overt hyperthyroidism is 0...
- Iodine-induced hyperthyroidism--an epidemiological survey several years after institution of iodine prophylaxis in PolandA Lewinski
Department of Thyroidology, Medical University of Lodz, Poland
J Endocrinol Invest 26:57-62. 2003..In order to monitor possible side-effects of increased iodine supply, studies on iodine-induced hyperthyroidism were initiated by establishing several regional registers of hyperthyroidism...
- Experimental hyperthyroidism-induced oxidative stress and impairment of antioxidant defence system in rat testisDipak K Sahoo
Department of Biotechnology, Utkal University, Bhubaneswar 7510 04, India
Indian J Exp Biol 43:1058-67. 2005Short-term hyperthyroidism, induced by daily administration of T3 (20 microg/100g body weight) for one, three, and five days consecutively, modulates oxidative stress and antioxidant defence parameters in mitochondrial and ..
- Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunctionSubhashini Yaturu
Department of Endocrinology, VAMC LSU HSC, Shreveport, Louisiana 71101 4295, USA
J Cell Biochem 93:491-6. 2004..and leptin in 69 subjects with Graves' disease before and 32 patients at follow up after treatment for hyperthyroidism at hypothyroid state...
- QTc dispersion in hyperthyroidism and its association with pulmonary hypertensionUnal Guntekin
Yuzuncu Yil University, Faculty of Medicine, Cardiology Department, Van, Turkey
Pacing Clin Electrophysiol 32:494-9. 2009Several studies have reported that hyperthyroidism is associated with prolonged QT interval corrected by the heart rate (QTc) and pulmonary hypertension (PHT).
- Association of iodine fortification with incident use of antithyroid medication--a Danish Nationwide StudyCharlotte Cerqueira
Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
J Clin Endocrinol Metab 94:2400-5. 2009Iodine-induced hyperthyroidism has been reported in the early phases of almost all iodine fortification programs, depending on prior iodine intake in the population, the amount of fortification, and the rate of change.
- Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathwayMurat Giris
Department of Biochemistry, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
J Surg Res 164:266-75. 2010The exact pathogenesis of hepatic dysfunction in hyperthyroidism is still unknown...
- High serum osteoprotegerin levels in patients with hyperthyroidism: effect of medical treatmentG Amato
Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, 80121, Naples, Italy
Bone 35:785-91. 2004This study was aimed at evaluating serum osteoprotegerin (OPG) concentrations in a cohort of patients with hyperthyroidism before and after methimazole (MMI) treatment...
- Color flow Doppler sonography for the etiologic diagnosis of hyperthyroidismMurat Faik Erdogan
Ankara University, Medical School, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey
Thyroid 17:223-8. 2007..We aimed to determine the value of CFDS for the etiological diagnosis of hyperthyroidism. Fifty-five patients with hyperthyroidism (29 Graves' disease [GD] and 26 toxic adenoma [TA]), 24 patients ..
- Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumorsS F Oosting
Department of Medical Oncology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Ann Oncol 21:104-8. 2010Patients with elevated human chorionic gonadotrophin (HCG) can have hyperthyroidism. We assessed the prevalence of hyperthyroidism in patients presenting with disseminated non-seminomatous germ-cell tumors (NSGCT).
- Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidismAziz Yazar
Department of Internal Medicine, Mersin University Medical School, Mersin, Turkey
Arch Med Res 34:35-40. 2003The aim of this study was to investigate systolic pulmonary artery pressure (SPAP) and serum uric acid (SUA) levels in patients with hyperthyroidism and after euthyroid state was reached.
- Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathyLaura Elbers
Department of Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands
Thyroid 21:279-83. 2011It is still debated which treatment modality for Graves' hyperthyroidism (GH) is most appropriate when Graves' orbitopathy (GO) is present...
- Thyroid status and nitric oxide in rat arterial vesselsR M McAllister
Department of Anatomy and Physiology and Kinesiology, Kansas State University, Manhattan, Kansas 66506, USA
J Endocrinol 185:111-9. 2005Thyroid disease has profound effects on cardiovascular function. Hypo- and hyperthyroidism, for example, are associated with reduced and increased maximal endothelium-dependent vasodilation respectively...
- Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the ratV Fernandez
Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago
Nitric Oxide 1:463-8. 1997b>Hyperthyroidism enhances the prooxidant activity of the liver by elevating superoxide radical and/or hydrogen peroxide generation in microsomal, mitochondrial, and peroxisomal fractions, with an increased respiratory burst of Kupffer ..
- Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidismWei Jan Chen
First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Fu Shin Road no 5, Kwei Shan, Tao Yuan, Taiwan
Basic Res Cardiol 106:163-74. 2011Atrial fibrillation (AF) is a common complication in hyperthyroidism. Earlier studies demonstrate that thyroid hormone decreases L-type calcium channel (LCC) current expression with resultant shortening of action potential duration (APD),..
- Safety and efficacy of surgical management of hyperthyroidism: 15-year experience from a tertiary care center in a developing countryP V Pradeep
Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareillei Road, Lucknow, Uttar Pradesh, 226014, India
World J Surg 31:306-12; discussion 313. 2007..In this paper, we discuss the experience of the surgical management of hyperthyroidism at a specialized tertiary care endocrine center in a developing country, highlighting the minimal morbidity ..
- Thyroid hormone use, hyperthyroidism and mortality in older womenDouglas C Bauer
Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
Am J Med 120:343-9. 2007..The safety of thyroid hormone use and long-term prognosis of hyperthyroidism remain controversial...
- CD8+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine modelOhki Saitoh
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, Japan
Endocrinology 148:6040-6. 2007..antibody mediated depletion of CD4(+)CD25(+) regulatory T cells (Tregs) enhances incidence and severity of hyperthyroidism in resistant and susceptible mouse strains, respectively...
- Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptorP Kopp
Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA
J Clin Invest 100:1634-9. 1997..cause of hyperfunctioning thyroid adenomas, and germline mutations have been found in familial nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism...
- Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based studyAllan Carlé
Department of Endocrinology and Internal Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
Eur J Endocrinol 164:801-9. 2011Few population-based studies have described the epidemiology of subtypes of hyperthyroidism.
- Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidismLibuse Tauchmanova
Department of Molecular and Clinical Endocrinology and Oncology, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
Maturitas 48:299-306. 2004Although overt hyperthyroidism is a well known cause of bone loss, systemic effects of subclinical hyperthyroidism (SH) are still a matter of debate...
- Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)Isabela M Bensenor
Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
BMC Public Health 10:298. 2010Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people
- Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidismK Boelaert
Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
Clin Endocrinol (Oxf) 70:129-38. 2009There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism.
- Hyperthyroidism--cause of depression and psychosis: a case reportG Marian
UMF Carol Davila, Clinical Hospital Prof Dr AI Obregia, Bucharest, Romania
J Med Life 2:440-2. 2009..Psychotic symptoms in the context of hyperthyroidism typically present as an affective psychosis...
- Severe acute renal failure due to tubulointerstitial nephritis, pancreatitis, and hyperthyroidism in a patient during rifampicin therapySaime Paydas
Department of Nephrology, Cukurova University School of Medicine, Balcali, Adana, Turkey
Adv Ther 22:241-3. 2005It is well known that rifampicin can cause nephrotoxicity. Rifampicin-related pancreatitis and hyperthyroidism are rarely reported in the same patient in the presence of tubulointerstitial nephritis...
- Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in ChinaFan Yang
Department of Endocrinology and Metabolism, First Affiliated Hospital, China Medical University, No 155 Nanjing Bei St, Heping District, Shenyang, China
Eur J Endocrinol 156:403-8. 2007An increasing incidence of hyperthyroidism has been observed when iodine supplementation has been introduced to an iodine-deficient population...
- Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort StudyM Hatch
Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Rockville, Maryland 20852, USA
Radiat Res 174:763-72. 2010Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels...
- Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specificK Ojamaa
Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
Endocrinology 140:3170-6. 1999..5 mRNA (6.10+/-0.37x10(-20) mol/microg RNA) was unaltered by thyroid hormone status. The myocyte-specific and chamber-selective expression of Kv1.5 mRNA was confirmed in primary cultures of rat atrial and ventricular myocytes...
- Subclinical hyperthyroidism and pregnancy outcomesBrian M Casey
Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
Obstet Gynecol 107:337-41. 2006Subclinical hyperthyroidism has long-term sequelae that include osteoporosis, cardiovascular morbidity, and progression to overt thyrotoxicosis or thyroid failure...
- Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidismC Rochon
Unité de Nutrition et Métabolisme Protéique, INRA Centre de Clermont Ferrand, 63122 Saint Genes Champanelle, France
Clin Sci (Lond) 104:7-15. 2003..thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps...
- Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidismAlev E Altinova
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
Clin Endocrinol (Oxf) 65:530-5. 2006..The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction...
- The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidismA S R Araujo
Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050 170 Porto Alegre, RS, Brazil
J Mol Endocrinol 41:423-30. 2008..protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were divided into four groups: control, vitamin E, thyroxine (T(4)), and T(4)+vitamin E...
- Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutationsA Hebrant
School of Medicine, Institute of Interdisciplinary Research IRIBHM, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
Eur J Endocrinol 164:1-9. 2011Three syndromes affecting the thyroid gland are described in the literature separately: familial nonautoimmune hyperthyroidism, sporadic congenital nonautoimmune hyperthyroidism, and autonomous adenomas...
- Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort studyHenry Volzke
SHIP Clinical Epidemiological Research Unit, Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
Eur J Endocrinol 161:615-21. 2009There is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet...
- Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidismL Duprez
Institut de Recherche Interdisciplinaire, Faculty of Medicine, University of Brussels, Belgium
Nat Genet 7:396-401. 1994..mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) ..
- Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in miceYumiko Mizutori
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
J Autoimmun 26:32-6. 2006..injected with dendritic cells (DCs) infected with adenovirus encoding the full-length TSHR (AdTSHR) develop hyperthyroidism, albeit at a low incidence (36%)...
- Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patientsB Biondi
Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
J Clin Endocrinol Metab 85:4701-5. 2000To determine the clinical impact of endogenous subclinical hyperthyroidism, specific symptoms and signs of thyroid hormone excess and quality of life were assessed in 23 patients (3 males and 20 females; mean age, 43 +/- 9 yr) and 23 age-..
- Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnoverKamal A S Al-Shoumer
Division of Endocrinology and Metabolic Medicine, Mubarak Al Kabeer Hospital, Jabriya, and the Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
Endocr Pract 12:121-30. 2006To study glucose and bone metabolism in hyperthyroidism, assess their changes after treatment, and investigate their interrelationships.
- Insulin resistance in hyperthyroidism: the role of IL6 and TNF alphaPanayota Mitrou
Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
Eur J Endocrinol 162:121-6. 2010Although insulin resistance is a common finding in hyperthyroidism, the implicated mechanisms are obscure...
- Studies of insulin resistance in patients with clinical and subclinical hyperthyroidismEirini Maratou
Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
Eur J Endocrinol 163:625-30. 2010Although clinical hyperthyroidism (HR) is associated with insulin resistance, the information on insulin action in subclinical hyperthyroidism (SHR) is limited.
- Thyroid hormone and the cardiovascular systemS Danzi
Division of Endocrinology, Department of Medicine, North Shore University Hospital NYU School of Medicine and North Shore LIJ Research Institute, Manhasset, NY 11030, USA
Minerva Endocrinol 29:139-50. 2004..In hyperthyroidism, cardiac contractility and cardiac output are enhanced and systemic vascular resistance is decreased, while ..
- Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohortsT H Brix
Department of Endocrinology, Odense University Hospital, Denmark
J Clin Endocrinol Metab 86:930-4. 2001..In conclusion, our study strongly supports the idea that genetic factors play a major role in the etiology of GD and suggest that a further search for susceptibility genes is worthwhile...
- Increased cardiovascular and cancer mortality after radioiodine treatment for hyperthyroidismSaara Metso
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
J Clin Endocrinol Metab 92:2190-6. 2007Patients treated with radioiodine (RAI) for hyperthyroidism have been reported to be at increased risk for death. It is not clear whether the increased mortality is due to hyperthyroidism itself or the effect of RAI.
- Haemodynamic changes following treatment of subclinical and overt hyperthyroidismJ Faber
Department of Endocrinology E, Frederiksberg Hospital, DK 2000, Denmark
Eur J Endocrinol 145:391-6. 2001b>Hyperthyroidism has profound effects on the cardiovascular system, including reduced systemic vascular resistance (SVR) due to relaxation of vascular smooth muscle cells, enhanced heart rate (HR) and cardiac output (CO) due to an ..
- Evaluation of oxidative status in patients with hyperthyroidismMehmet Aslan
Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey
Endocrine 40:285-9. 2011Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism...
- Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid anginaRupa Patel
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9066, USA
Thyroid 18:273-6. 2008..Subsequently, she was diagnosed with hyperthyroidism and treated with antithyroid therapy and oral nitrates...
- Subclinical hyperthyroidism as a risk factor for atrial fibrillationJ Auer
Division of Cardiology and Intensive Care, Department of Internal Medicine II, General Hospital Wels, Wels, Austria
Am Heart J 142:838-42. 2001Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically ..
- Glucose and lipid fluxes in the adipose tissue after meal ingestion in hyperthyroidismGeorge Dimitriadis
Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Attikon University Hospital, 1 Rimini Street, GR 12462 Haidari, Greece
J Clin Endocrinol Metab 91:1112-8. 2006Although insulin resistance is well established in hyperthyroidism, information on the effects of insulin on adipose tissue (AD) is limited.
- Plasma levels of coenzyme Q10 in children with hyperthyroidismThomas Menke
Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Dr Friedrich Steiner Strasse 5, DE 45711 Datteln, Germany
Horm Res 61:153-8. 2004In hyperthyroidism, increased oxygen consumption and free radical production in the stimulated respiratory chain leads to oxidative stress...
- Hyperthyroidism and cerebral venous thrombosisS Mouton
Cerebrovascular Disease Center, Lyon, France
Eur Neurol 54:78-80. 2005..The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII)...
- Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysisJennifer P Holst
Georgetown University Washington Hospital Center, Washington, DC, USA
Thyroid 15:1321-31. 2005Treatment with radioactive iodine ((131)I) may be necessary for thyroid cancer or for hyperthyroidism in patients with end-stage renal disease who require hemodialysis...
- Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidismAli Cetinkaya
Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey
Mediators Inflamm 2005:57-9. 2005We aimed to determine whether patients with subclinical hyperthyroidism (SH) are subject to oxidative stress...
- Duration of the P wave and P wave dispersion in subclinical hyperthyroidismBerrin Cetinarslan
Department of Endocrinology and Metabolism, University of Kocaeli School of Medicine, Derince, Kocaeli, Turkey 41900
Endocr Pract 9:200-3. 2003..and adjusted Pdis, which are simple noninvasive electrocardiographic markers to detect paroxysmal atrial fibrillation, differ in patients with endogenous subclinical hyperthyroidism in comparison with those in healthy control subjects.
- Increased risk of affective disorder following hospitalisation with hyperthyroidism - a register-based studyAnders F Thomsen
Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Denmark
Eur J Endocrinol 152:535-43. 2005..We assessed whether hospitalisation with hyperthyroidism was a risk factor for hospitalisation with affective disorder and evaluated the temporal relationship between ..
- Hyperthyroidism: a rare cause of reversible pulmonary hypertensionRock Wasseem
Department of Internal Medicine C, Hae meK Medical Center, Afula 18101, Israel
Am J Med Sci 332:140-1. 2006..Possible mechanisms for the development of pulmonary arterial hypertension due to hyperthyroidism include damage to pulmonary vascular endothelium due to high cardiac output or an autoimmune process or ..
- Antioxidants in patients with hyperthyroidismLjiljana Mayer
Department of Laboratory Medicine, Dubrava University Hospital, Zagreb, Croatia
Clin Chem Lab Med 42:154-8. 2004b>Hyperthyroidism is a hypermetabolic state accompanied by increased oxygen utilization, increased production of reactive oxygen species and consequentially measurable changes in antioxidative factors...
- Sleepwalking associated with hyperthyroidismKamel M Ajlouni
National Center for Diabetes, Endocrinology and Genetics, Amman 11942, Jordan
Endocr Pract 11:5-10. 2005To report several cases of hyperthyroidism in patients presenting with the unusual symptom of sleepwalking and to discuss the possible pathophysiologic basis for this novel association.
- Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activityCihangir Erem
Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Trabzon, Turkey
Clin Endocrinol (Oxf) 64:323-9. 2006..On the other hand, subclinical hyperthyroidism (SCHyper) is associated with enhanced cardiovascular risk...
- Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidismAyse S Cikim
Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Inonu University, Malatya, Turkey
Thyroid 14:605-9. 2004Subclinical hypothyroidism and subclinical hyperthyroidism are two frequently occurring conditions for which exact therapeutic approaches have not yet been established...
- [Hyperthyroidism in the elderly]M Simi
Chirurgia Generale Dipartimento di Chirurgia P Stefanini Università di Roma La Sapienza
Ann Ital Chir 76:19-22. 2005b>Hyperthyroidism in elderly patients is not to be under-evaluated, since it is characterized in such age range by particular clinical and prognostic features...
- 5: Diagnosis and management of hyperthyroidism and hypothyroidismDuncan J Topliss
Department of Endocrinology and Diabetes, Alfred Hospital, Melbourne, VIC 3004, Australia
Med J Aust 180:186-93. 2004The most common cause of hyperthyroidism in Australia is Graves disease, caused by a defect in immunoregulation in genetically predisposed individuals, leading to production of thyroid-stimulating antibodies...
- Endothelial dysfunction in subjects with subclinical hyperthyroidismE Coban
Department of Internal Medicine, Akdeniz University Faculty of Medicine, 07070 Antalya, Turkey
J Endocrinol Invest 29:197-200. 2006..9+/-9.6 vs 37.6+/-6.4%, p=0.026). In conclusion, our results suggest that subjects with subclinical hyperthyroidism tend to have an endothelial dysfunction...
- Pregnancy complicated with pulmonary edema due to hyperthyroidismMing Jie Yang
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
J Chin Med Assoc 68:336-8. 2005b>Hyperthyroidism is one of the most common causes of cardiac failure. Blood volume expands greatly during pregnancy, especially after the last part of the second trimester...
- Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidismMaren Claus
III Medical Department, University of Leipzig, Leipzig, Germany
Thyroid 15:1089-94. 2005Hereditary nonautoimmune hyperthyroidism is caused by activating thyrotropin receptor (TSHR) germline mutations. We describe a family from Saxony, Germany, with this condition...
- Thyroid disorders. Part I: hyperthyroidismJames W Little
University of Minnesota, Minneapolis, Minnesota, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:276-84. 2006..This article (part I) deals with hyperthyroidism, part II with hypothyroidism and thyroiditis, and part III with neoplastic lesions of the thyroid...
- TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5Beate Karges
Pediatric Endocrinology, University Children s Hospital, University of Ulm, Prittwitzstrasse 43, D 89075 Ulm, Germany
J Endocrinol 186:377-85. 2005Mutations of the human thyrotrophin receptor (TSH-R) are a cause of thyroid adenomas and hyperthyroidism. Here we study mechanisms of receptor activation in a genomic TSH-R variant V509A located in transmembrane helix (TMH) 3, which we ..
- Hyperplacentosis: a novel cause of hyperthyroidismJ Ginsberg
Department of Medicine, University of Alberta, Edmonton, Canada
Thyroid 11:393-6. 2001Human chorionic gonadotropin (hCG), which is capable of thyrotropic activity, is believed responsible for the hyperthyroidism of gestational trophoblastic disease and hyperemesis gravidarum...
- A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6Franziska Winkler
Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
J Clin Endocrinol Metab 95:3605-10. 2010Activating mutations in the TSHR gene were found in patients suffering from nonautoimmune hyperthyroidism. In the past, it was assumed that thyroid hyperplasia is due to constitutive activation of the Gs/adenylyl cyclase signaling ..
- The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidismH Biebermann
Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
J Clin Endocrinol Metab 86:4429-33. 2001Sporadic and familial nonautoimmune hyperthyroidism are very rarely occurring diseases. Within the last years constitutively activating TSH receptor mutations were identified as one possible pathomechanism...
- Is hyperthyroidism underestimated in pregnancy and misdiagnosed as hyperemesis gravidarum?Ana Tikvica Luetic
Department of Obstetrics and Gynecology, General Hospital Sveti Duh, Sveti Duh 64, 10 000 Zagreb, Croatia
Med Hypotheses 75:383-6. 2010..However, hyperthyroidism occurs in pregnancy with clinical presentation similar to hyperemesis gravidarum (HG) and pregnancy itself...
- Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemmaBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Eur J Endocrinol 162:587-9. 2010The association of endogenous subclinical hyperthyroidism (SHyper) with cardiovascular mortality is controversial...
- Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred miceB Rapoport
Cedars Sinai Research Institute and UCLA School of Medicine, Los Angeles, CA 90048, USA
Genes Immun 11:254-63. 2010Graves' hyperthyroidism is an autoimmune disease occurring spontaneously in humans and caused by autoantibodies that stimulate the thyrotropin receptor...
- Body weight and body composition changes after treatment of hyperthyroidismL Lonn
Department of Radiology, Sahlgrenska University Hospital, University of Goteborg, Sweden
J Clin Endocrinol Metab 83:4269-73. 1998Body composition changes in nine adults with hyperthyroidism were determined with dual energy x-ray absorptiometry and computed tomography at diagnosis and after 3 and 12 months of euthyroidism achieved by surgery, antithyroid drugs, or ..
- Graves' Disease Therapy Risks to Mother and FetusScott A Rivkees; Fiscal Year: 2010Graves'disease (GD) accounts for the vast majority of cases of hyperthyroidism in young adults...
- ANIMAL MODELS OF HYPERTHYROIDISMSandra M McLachlan; Fiscal Year: 2010..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
- GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICESandra M McLachlan; Fiscal Year: 2010Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
- GONADOTROPIN ACTIONWilliam R Moyle; Fiscal Year: 2010..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
- ANIMAL MODELS OF HYPERTHYROIDISMSandra McLachlan; Fiscal Year: 2009..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
- NADPH P450 REDUCTASE--THYROID HORMONE REGULATIONDavid Waxman; Fiscal Year: 2002..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
- PHYSIOLOGICAL ROLE OF THYROXINE BINDING PROTEINSPHILIP LARSEN; Fiscal Year: 1992..In addition, we will examine the effects of hypo- and hyperthyroidism (T3 induced) and hypopituitarism on the response of their cells to those hormones...
- Binding Determinants of Glycoprotein Hormone ReceptorsJ PUETT; Fiscal Year: 2007..Mutations, activating or inactivating GpHR function, have been identified in hyperthyroidism, precocious puberty and pseudohermaphroditism; moreover, polymorphic variants of LH and FSH receptors have ..
- PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSIONPHILIP LARSEN; Fiscal Year: 2005..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
- COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONERonald Cohen; Fiscal Year: 2002..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
- GONADOTROPIN ACTIONWilliam Moyle; Fiscal Year: 2007..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
- Identifying Genes Linked to Autoimmune Thyroid DiseasesYaron Tomer; Fiscal Year: 2006..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
- MECHANISM OF ACTION OF THYROID HORMONE RECEPTORSRONALD KOENIG; Fiscal Year: 1993..in various tissues, and therefore to understanding the basis for the signs and symptoms of hypothyroidism and hyperthyroidism. Techniques employed to address these questions will include gel shift and avidin biotin complex to DNA ..
- Subclinical thyroid dysfunction in the elderlyAnne R Cappola; Fiscal Year: 2010..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
- EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASEBellur Prabhakar; Fiscal Year: 2003Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
- The role of chemokines in experimental thyroiditisSergio Lira; Fiscal Year: 2007..forms of AITD are Hashimoto's thyroiditis (HT), causing hypothyroidism, and Graves' disease (GD), causing hyperthyroidism. The hallmark of these conditions is thyroid dysfunction associated with the presence of lymphocytic ..