hyperthyroidism

Summary

Summary: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.

Top Publications

  1. ncbi Thyroid function and mortality in patients treated for hyperthyroidism
    Jayne A Franklyn
    Division of Medical Sciences, University of Birmingham, England
    JAMA 294:71-80. 2005
  2. ncbi Serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid function
    Ching Jung Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Endocr J 55:489-94. 2008
  3. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
  4. doi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn Chair
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Thyroid 21:593-646. 2011
  5. doi Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline
    LESLIE DE GROOT
    University of Rhode Island, Providence, Rhode Island 02881, USA
    J Clin Endocrinol Metab 97:2543-65. 2012
  6. doi Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease
    Chaoming Mao
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 186:4734-43. 2011
  7. ncbi Cardiovascular involvement in patients with different causes of hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Nat Rev Endocrinol 6:431-43. 2010
  8. ncbi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA
    Endocr Pract 17:456-520. 2011
  9. ncbi Hyperthyroidism
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
    Lancet 362:459-68. 2003
  10. pmc Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
    Tinh Hai Collet
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Arch Intern Med 172:799-809. 2012

Research Grants

  1. Graves' Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2010
  2. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2010
  3. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2010
  4. GONADOTROPIN ACTION
    William R Moyle; Fiscal Year: 2010
  5. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra McLachlan; Fiscal Year: 2009
  6. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
  7. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
  8. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
  9. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2010
  10. Heart Vascular Function and Thyroid Hormone Receptors
    Wolfgang H Dillmann; Fiscal Year: 2013

Detail Information

Publications340 found, 100 shown here

  1. ncbi Thyroid function and mortality in patients treated for hyperthyroidism
    Jayne A Franklyn
    Division of Medical Sciences, University of Birmingham, England
    JAMA 294:71-80. 2005
    b>Hyperthyroidism has been reported to cause excess all-cause and circulatory mortality. Whether this can be reversed is unknown, as is the influence of mild persisting thyroid dysfunction and treatment-induced hypothyroidism.
  2. ncbi Serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid function
    Ching Jung Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Endocr J 55:489-94. 2008
    ..The aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication...
  3. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
    ..Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age...
  4. doi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn Chair
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Thyroid 21:593-646. 2011
    ..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
  5. doi Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline
    LESLIE DE GROOT
    University of Rhode Island, Providence, Rhode Island 02881, USA
    J Clin Endocrinol Metab 97:2543-65. 2012
    ..A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at http://jcem.endojournals.org)...
  6. doi Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease
    Chaoming Mao
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 186:4734-43. 2011
    ..Collectively, uGD-derived DCs through pDC polarization and elevated thyroid hormones act in concert to impair the regulatory capacity of Treg cells, facilitating the production of TSHR autoantibodies in the pathogenesis of GD...
  7. ncbi Cardiovascular involvement in patients with different causes of hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Nat Rev Endocrinol 6:431-43. 2010
    Various clinical disorders can cause hyperthyroidism, the effects of which vary according to the patient's age, severity of clinical presentation and association with other comorbidities...
  8. ncbi Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists
    Rebecca S Bahn
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA
    Endocr Pract 17:456-520. 2011
    ..This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition...
  9. ncbi Hyperthyroidism
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
    Lancet 362:459-68. 2003
    b>Hyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone...
  10. pmc Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
    Tinh Hai Collet
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Arch Intern Med 172:799-809. 2012
    Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting...
  11. ncbi Myocardial antioxidant enzyme activities and concentration and glutathione metabolism in experimental hyperthyroidism
    A S R Araujo
    Departamento Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Mol Cell Endocrinol 249:133-9. 2006
    b>Hyperthyroidism was induced in rats by l-thyroxine administration (12 mg/L in drinking water, 4 weeks). Animals were assessed hemodynamically, and heart, lung, and liver morphometry were performed...
  12. doi Thyroid hormone and the cardiovascular system
    Sara Danzi
    Department of Biological Sciences and Geology, Queensborough Community College, Bayside, NY 11364, USA
    Med Clin North Am 96:257-68. 2012
    ..The characteristic changes in cardiovascular hemodynamics and metabolism that accompany thyroid disease states can then be best understood at the cellular level...
  13. ncbi Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart
    M Lopez-Torres
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040, Madrid, Spain
    Mol Cell Endocrinol 168:127-34. 2000
    ..05). Hyperthyroidism did not significantly change heart mitochondrial H(2)O(2) production since the increase in State 4 oxygen ..
  14. doi The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidism
    Thenmalar Vadiveloo
    Dundee Epidemiology and Biostatistics Unit, Division of Clinical and Population Sciences and Education, Mackenzie Building, Kirsty Semple Way, University of Dundee, Dundee, Scotland, DD2 4BF United Kingdom
    J Clin Endocrinol Metab 96:1344-51. 2011
    Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH).
  15. doi Thyroid cancer in patients with hyperthyroidism
    K Pazaitou-Panayiotou
    Department of Endocrinology Endocrine Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece
    Horm Metab Res 44:255-62. 2012
    ..The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects ..
  16. ncbi Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition
    Gerasimos E Krassas
    Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
    Eur J Endocrinol 153:217-21. 2005
    ..To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results...
  17. doi Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals
    Renate T de Jongh
    Department of Internal Medicine and Endocrinology EMGO Institute for Health and Care Research Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 165:545-54. 2011
    ..To what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate...
  18. ncbi Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease
    Hirotoshi Nakamura
    Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
    J Clin Endocrinol Metab 92:2157-62. 2007
    Although methimazole (MMI) and propylthiouracil (PTU) have long been used to treat hyperthyroidism caused by Graves' disease (GD), there is still no clear conclusion about the choice of drug or appropriate initial doses.
  19. pmc Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study
    Graziano Ceresini
    Department of Geriatrics, Endocrine Unit, University of Parma, Italy
    J Am Geriatr Soc 57:89-93. 2009
    ..To investigate thyroid function testing abnormalities in older persons and to explore the relationship between thyroid dysfunction and cognition...
  20. ncbi Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Clin Endocrinol (Oxf) 59:621-9. 2003
    ..The aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy...
  21. doi Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment
    Florentia Kaguelidou
    Institut National de la Santé et de la Recherche Médicale U690, Hopital Robert Debre, 75019 Paris, France
    J Clin Endocrinol Metab 93:3817-26. 2008
    ..There is debate about how Graves' disease (GD) should be treated in children...
  22. ncbi Influence of iodine-131 dose on the outcome of hyperthyroidism in children
    Scott A Rivkees
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Pediatrics 111:745-9. 2003
    Iodine-131 is an effective treatment for Graves' hyperthyroidism in children and adults. Yet the responses to treatment as related to iodine-131 dose in children are not well-defined...
  23. doi Mechanisms in endocrinology: Heart failure and thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Italy
    Eur J Endocrinol 167:609-18. 2012
    ..The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction...
  24. doi Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart
    Lisa C Heather
    Department of Physiology, Anatomy, and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom
    Endocrinology 151:422-31. 2010
    ..Here we determined the effect of hyperthyroidism on substrate metabolism in the isolated, perfused, contracting rat heart...
  25. doi Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012
    b>Hyperthyroidism is characterized in rats by increased energy expenditure and marked hyperphagia...
  26. ncbi Oxidative stress in heart tissue of hyperthyroid and iron supplemented rats
    S Civelek
    Department of Biochemistry, Cerrahpasa Medical Facility, Istanbul University, Turkey
    J Toxicol Environ Health A 64:499-506. 2001
    This study was designed to investigate the effect of hyperthyroidism and/or iron supplementation or cardiac oxidative stress parameters--the lipid peroxidation end product glutathione (GSH), glutathione peroxidase (CSH-Px), and ..
  27. doi The utility of radioiodine uptake and thyroid scintigraphy in the diagnosis and management of hyperthyroidism
    O E Okosieme
    Department of Endocrinology and Diabetes, Prince Charles Hospital, Cwm Taff NHS Trust, Merthyr Tydfil, Mid Glamorgan
    Clin Endocrinol (Oxf) 72:122-7. 2010
    The value and practice of thyroid radionuclide imaging in the diagnosis and management of hyperthyroidism is unsettled...
  28. doi Overt hyperthyroidism and hypothyroidism during pregnancy
    Alex Stagnaro-Green
    George Washington University School of Medicine and Health Sciences, Washington, DC, USA
    Clin Obstet Gynecol 54:478-87. 2011
    ..manuscript provides a definition for, and evaluates the prevalence and maternal/fetal/child impact of, overt hyperthyroidism and overt hypothyroidism. The prevalence of overt hyperthyroidism is 0...
  29. ncbi Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aahus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:411-9. 2002
    To study fracture risk in patients with hyperthyroidism and hypothyroidism.
  30. ncbi Redox regulation of myocardial ERK 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin system
    Alex Sander da Rosa Araujo
    Department of Physiology, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cardiovasc Pharmacol 56:513-7. 2010
    ..adaptation in the antioxidant system would differentially modulate prosurvival and proapoptotic proteins in hyperthyroidism-induced cardiac hypertrophy...
  31. doi A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Eur J Endocrinol 165:491-7. 2011
    Overt hyperthyroidism has been associated with cardiac arrhythmias, hypercoagulopathy, stroke, and pulmonary embolism, all of which may increase mortality...
  32. ncbi Effects of hypothyroidism induced by 6-n-propylthiouracil and its reversal by T3 on rat heart superoxide dismutase, catalase and lipid peroxidation
    S Chattopadhyay
    Department of Biotechnology, Utkal University, Bhubaneswar 751004, India
    Indian J Exp Biol 41:846-9. 2003
    ..b>Hyperthyroidism registered increased SOD activity in post-mitochondrial fraction...
  33. doi Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy
    Laura Elbers
    Department of Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 21:279-83. 2011
    It is still debated which treatment modality for Graves' hyperthyroidism (GH) is most appropriate when Graves' orbitopathy (GO) is present...
  34. pmc Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor
    P Kopp
    Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Invest 100:1634-9. 1997
    ..cause of hyperfunctioning thyroid adenomas, and germline mutations have been found in familial nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism...
  35. doi Association of iodine fortification with incident use of antithyroid medication--a Danish Nationwide Study
    Charlotte Cerqueira
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    J Clin Endocrinol Metab 94:2400-5. 2009
    Iodine-induced hyperthyroidism has been reported in the early phases of almost all iodine fortification programs, depending on prior iodine intake in the population, the amount of fortification, and the rate of change.
  36. doi Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism
    Wei Jan Chen
    First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Fu Shin Road no 5, Kwei Shan, Tao Yuan, Taiwan
    Basic Res Cardiol 106:163-74. 2011
    Atrial fibrillation (AF) is a common complication in hyperthyroidism. Earlier studies demonstrate that thyroid hormone decreases L-type calcium channel (LCC) current expression with resultant shortening of action potential duration (APD),..
  37. ncbi Safety and efficacy of surgical management of hyperthyroidism: 15-year experience from a tertiary care center in a developing country
    P V Pradeep
    Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareillei Road, Lucknow, Uttar Pradesh, 226014, India
    World J Surg 31:306-12; discussion 313. 2007
    ..In this paper, we discuss the experience of the surgical management of hyperthyroidism at a specialized tertiary care endocrine center in a developing country, highlighting the minimal morbidity ..
  38. ncbi High serum osteoprotegerin levels in patients with hyperthyroidism: effect of medical treatment
    G Amato
    Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, 80121, Naples, Italy
    Bone 35:785-91. 2004
    This study was aimed at evaluating serum osteoprotegerin (OPG) concentrations in a cohort of patients with hyperthyroidism before and after methimazole (MMI) treatment...
  39. ncbi Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat
    V Fernandez
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago
    Nitric Oxide 1:463-8. 1997
    b>Hyperthyroidism enhances the prooxidant activity of the liver by elevating superoxide radical and/or hydrogen peroxide generation in microsomal, mitochondrial, and peroxisomal fractions, with an increased respiratory burst of Kupffer ..
  40. ncbi Experimental hyperthyroidism-induced oxidative stress and impairment of antioxidant defence system in rat testis
    Dipak K Sahoo
    Department of Biotechnology, Utkal University, Bhubaneswar 7510 04, India
    Indian J Exp Biol 43:1058-67. 2005
    Short-term hyperthyroidism, induced by daily administration of T3 (20 microg/100g body weight) for one, three, and five days consecutively, modulates oxidative stress and antioxidant defence parameters in mitochondrial and ..
  41. ncbi Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidism
    Aziz Yazar
    Department of Internal Medicine, Mersin University Medical School, Mersin, Turkey
    Arch Med Res 34:35-40. 2003
    The aim of this study was to investigate systolic pulmonary artery pressure (SPAP) and serum uric acid (SUA) levels in patients with hyperthyroidism and after euthyroid state was reached.
  42. doi Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathway
    Murat Giris
    Department of Biochemistry, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    J Surg Res 164:266-75. 2010
    The exact pathogenesis of hepatic dysfunction in hyperthyroidism is still unknown...
  43. ncbi Thyroid hormone use, hyperthyroidism and mortality in older women
    Douglas C Bauer
    Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
    Am J Med 120:343-9. 2007
    ..The safety of thyroid hormone use and long-term prognosis of hyperthyroidism remain controversial...
  44. ncbi Color flow Doppler sonography for the etiologic diagnosis of hyperthyroidism
    Murat Faik Erdogan
    Ankara University, Medical School, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey
    Thyroid 17:223-8. 2007
    ..We aimed to determine the value of CFDS for the etiological diagnosis of hyperthyroidism. Fifty-five patients with hyperthyroidism (29 Graves' disease [GD] and 26 toxic adenoma [TA]), 24 patients ..
  45. ncbi Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunction
    Subhashini Yaturu
    Department of Endocrinology, VAMC LSU HSC, Shreveport, Louisiana 71101 4295, USA
    J Cell Biochem 93:491-6. 2004
    ..and leptin in 69 subjects with Graves' disease before and 32 patients at follow up after treatment for hyperthyroidism at hypothyroid state...
  46. doi QTc dispersion in hyperthyroidism and its association with pulmonary hypertension
    Unal Guntekin
    Yuzuncu Yil University, Faculty of Medicine, Cardiology Department, Van, Turkey
    Pacing Clin Electrophysiol 32:494-9. 2009
    Several studies have reported that hyperthyroidism is associated with prolonged QT interval corrected by the heart rate (QTc) and pulmonary hypertension (PHT).
  47. ncbi CD8+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model
    Ohki Saitoh
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, Japan
    Endocrinology 148:6040-6. 2007
    ..antibody mediated depletion of CD4(+)CD25(+) regulatory T cells (Tregs) enhances incidence and severity of hyperthyroidism in resistant and susceptible mouse strains, respectively...
  48. doi Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumors
    S F Oosting
    Department of Medical Oncology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Ann Oncol 21:104-8. 2010
    Patients with elevated human chorionic gonadotrophin (HCG) can have hyperthyroidism. We assessed the prevalence of hyperthyroidism in patients presenting with disseminated non-seminomatous germ-cell tumors (NSGCT).
  49. ncbi Thyroid status and nitric oxide in rat arterial vessels
    R M McAllister
    Department of Anatomy and Physiology and Kinesiology, Kansas State University, Manhattan, Kansas 66506, USA
    J Endocrinol 185:111-9. 2005
    Thyroid disease has profound effects on cardiovascular function. Hypo- and hyperthyroidism, for example, are associated with reduced and increased maximal endothelium-dependent vasodilation respectively...
  50. ncbi Iodine-induced hyperthyroidism--an epidemiological survey several years after institution of iodine prophylaxis in Poland
    A Lewinski
    Department of Thyroidology, Medical University of Lodz, Poland
    J Endocrinol Invest 26:57-62. 2003
    ..In order to monitor possible side-effects of increased iodine supply, studies on iodine-induced hyperthyroidism were initiated by establishing several regional registers of hyperthyroidism...
  51. doi Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study
    Allan Carlé
    Department of Endocrinology and Internal Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Eur J Endocrinol 164:801-9. 2011
    Few population-based studies have described the epidemiology of subtypes of hyperthyroidism.
  52. pmc Hyperthyroidism--cause of depression and psychosis: a case report
    G Marian
    UMF Carol Davila, Clinical Hospital Prof Dr AI Obregia, Bucharest, Romania
    J Med Life 2:440-2. 2009
    ..Psychotic symptoms in the context of hyperthyroidism typically present as an affective psychosis...
  53. ncbi Severe acute renal failure due to tubulointerstitial nephritis, pancreatitis, and hyperthyroidism in a patient during rifampicin therapy
    Saime Paydas
    Department of Nephrology, Cukurova University School of Medicine, Balcali, Adana, Turkey
    Adv Ther 22:241-3. 2005
    It is well known that rifampicin can cause nephrotoxicity. Rifampicin-related pancreatitis and hyperthyroidism are rarely reported in the same patient in the presence of tubulointerstitial nephritis...
  54. ncbi Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China
    Fan Yang
    Department of Endocrinology and Metabolism, First Affiliated Hospital, China Medical University, No 155 Nanjing Bei St, Heping District, Shenyang, China
    Eur J Endocrinol 156:403-8. 2007
    An increasing incidence of hyperthyroidism has been observed when iodine supplementation has been introduced to an iodine-deficient population...
  55. ncbi Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Maturitas 48:299-306. 2004
    Although overt hyperthyroidism is a well known cause of bone loss, systemic effects of subclinical hyperthyroidism (SH) are still a matter of debate.
  56. pmc Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)
    Isabela M Bensenor
    Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    BMC Public Health 10:298. 2010
    Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people
  57. pmc Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study
    M Hatch
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Rockville, Maryland 20852, USA
    Radiat Res 174:763-72. 2010
    Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels...
  58. doi Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism
    K Boelaert
    Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 70:129-38. 2009
    There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism.
  59. ncbi Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specific
    K Ojamaa
    Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
    Endocrinology 140:3170-6. 1999
    ..5 mRNA (6.10+/-0.37x10(-20) mol/microg RNA) was unaltered by thyroid hormone status. The myocyte-specific and chamber-selective expression of Kv1.5 mRNA was confirmed in primary cultures of rat atrial and ventricular myocytes...
  60. ncbi Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients
    B Biondi
    Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
    J Clin Endocrinol Metab 85:4701-5. 2000
    To determine the clinical impact of endogenous subclinical hyperthyroidism, specific symptoms and signs of thyroid hormone excess and quality of life were assessed in 23 patients (3 males and 20 females; mean age, 43 +/- 9 yr) and 23 age-..
  61. doi Insulin resistance in hyperthyroidism: the role of IL6 and TNF alpha
    Panayota Mitrou
    Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
    Eur J Endocrinol 162:121-6. 2010
    Although insulin resistance is a common finding in hyperthyroidism, the implicated mechanisms are obscure...
  62. ncbi Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism
    C Rochon
    Unité de Nutrition et Métabolisme Protéique, INRA Centre de Clermont Ferrand, 63122 Saint Genes Champanelle, France
    Clin Sci (Lond) 104:7-15. 2003
    ..thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps...
  63. doi Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort study
    Henry Volzke
    SHIP Clinical Epidemiological Research Unit, Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Eur J Endocrinol 161:615-21. 2009
    There is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet...
  64. ncbi Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice
    Yumiko Mizutori
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Autoimmun 26:32-6. 2006
    ..injected with dendritic cells (DCs) infected with adenovirus encoding the full-length TSHR (AdTSHR) develop hyperthyroidism, albeit at a low incidence (36%)...
  65. ncbi Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism
    L Duprez
    Institut de Recherche Interdisciplinaire, Faculty of Medicine, University of Brussels, Belgium
    Nat Genet 7:396-401. 1994
    ..mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) ..
  66. doi Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism
    Eirini Maratou
    Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
    Eur J Endocrinol 163:625-30. 2010
    Although clinical hyperthyroidism (HR) is associated with insulin resistance, the information on insulin action in subclinical hyperthyroidism (SHR) is limited.
  67. ncbi Subclinical hyperthyroidism and pregnancy outcomes
    Brian M Casey
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Obstet Gynecol 107:337-41. 2006
    Subclinical hyperthyroidism has long-term sequelae that include osteoporosis, cardiovascular morbidity, and progression to overt thyrotoxicosis or thyroid failure...
  68. ncbi Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism
    Alev E Altinova
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
    Clin Endocrinol (Oxf) 65:530-5. 2006
    ..The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction...
  69. doi The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism
    A S R Araujo
    Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050 170 Porto Alegre, RS, Brazil
    J Mol Endocrinol 41:423-30. 2008
    ..protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were divided into four groups: control, vitamin E, thyroxine (T(4)), and T(4)+vitamin E...
  70. doi Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations
    A Hebrant
    School of Medicine, Institute of Interdisciplinary Research IRIBHM, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
    Eur J Endocrinol 164:1-9. 2011
    Three syndromes affecting the thyroid gland are described in the literature separately: familial nonautoimmune hyperthyroidism, sporadic congenital nonautoimmune hyperthyroidism, and autonomous adenomas...
  71. ncbi Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnover
    Kamal A S Al-Shoumer
    Division of Endocrinology and Metabolic Medicine, Mubarak Al Kabeer Hospital, Jabriya, and the Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Endocr Pract 12:121-30. 2006
    To study glucose and bone metabolism in hyperthyroidism, assess their changes after treatment, and investigate their interrelationships.
  72. ncbi Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts
    T H Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 86:930-4. 2001
    ..In conclusion, our study strongly supports the idea that genetic factors play a major role in the etiology of GD and suggest that a further search for susceptibility genes is worthwhile...
  73. ncbi Thyroid hormone and the cardiovascular system
    S Danzi
    Division of Endocrinology, Department of Medicine, North Shore University Hospital NYU School of Medicine and North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Minerva Endocrinol 29:139-50. 2004
    ..In hyperthyroidism, cardiac contractility and cardiac output are enhanced and systemic vascular resistance is decreased, while ..
  74. doi Evaluation of oxidative status in patients with hyperthyroidism
    Mehmet Aslan
    Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey
    Endocrine 40:285-9. 2011
    Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism...
  75. ncbi Increased cardiovascular and cancer mortality after radioiodine treatment for hyperthyroidism
    Saara Metso
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Clin Endocrinol Metab 92:2190-6. 2007
    Patients treated with radioiodine (RAI) for hyperthyroidism have been reported to be at increased risk for death. It is not clear whether the increased mortality is due to hyperthyroidism itself or the effect of RAI.
  76. ncbi Haemodynamic changes following treatment of subclinical and overt hyperthyroidism
    J Faber
    Department of Endocrinology E, Frederiksberg Hospital, DK 2000, Denmark
    Eur J Endocrinol 145:391-6. 2001
    b>Hyperthyroidism has profound effects on the cardiovascular system, including reduced systemic vascular resistance (SVR) due to relaxation of vascular smooth muscle cells, enhanced heart rate (HR) and cardiac output (CO) due to an ..
  77. ncbi Subclinical hyperthyroidism as a risk factor for atrial fibrillation
    J Auer
    Division of Cardiology and Intensive Care, Department of Internal Medicine II, General Hospital Wels, Wels, Austria
    Am Heart J 142:838-42. 2001
    Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically ..
  78. doi Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid angina
    Rupa Patel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9066, USA
    Thyroid 18:273-6. 2008
    ..Subsequently, she was diagnosed with hyperthyroidism and treated with antithyroid therapy and oral nitrates...
  79. ncbi Glucose and lipid fluxes in the adipose tissue after meal ingestion in hyperthyroidism
    George Dimitriadis
    Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Attikon University Hospital, 1 Rimini Street, GR 12462 Haidari, Greece
    J Clin Endocrinol Metab 91:1112-8. 2006
    Although insulin resistance is well established in hyperthyroidism, information on the effects of insulin on adipose tissue (AD) is limited.
  80. ncbi Plasma levels of coenzyme Q10 in children with hyperthyroidism
    Thomas Menke
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Dr Friedrich Steiner Strasse 5, DE 45711 Datteln, Germany
    Horm Res 61:153-8. 2004
    In hyperthyroidism, increased oxygen consumption and free radical production in the stimulated respiratory chain leads to oxidative stress...
  81. ncbi Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysis
    Jennifer P Holst
    Georgetown University Washington Hospital Center, Washington, DC, USA
    Thyroid 15:1321-31. 2005
    Treatment with radioactive iodine ((131)I) may be necessary for thyroid cancer or for hyperthyroidism in patients with end-stage renal disease who require hemodialysis...
  82. ncbi Hyperthyroidism with fibrous dysplasia: an unusual presentation of McCune-Albright syndrome
    M H Bhat
    Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Exp Clin Endocrinol Diabetes 115:331-3. 2007
    ..b>Hyperthyroidism as a manifestation of endocrine hyperfunction in MAS is uncommon...
  83. ncbi Hyperthyroidism: a rare cause of reversible pulmonary hypertension
    Rock Wasseem
    Department of Internal Medicine C, Hae meK Medical Center, Afula 18101, Israel
    Am J Med Sci 332:140-1. 2006
    ..Possible mechanisms for the development of pulmonary arterial hypertension due to hyperthyroidism include damage to pulmonary vascular endothelium due to high cardiac output or an autoimmune process or ..
  84. ncbi TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5
    Beate Karges
    Pediatric Endocrinology, University Children s Hospital, University of Ulm, Prittwitzstrasse 43, D 89075 Ulm, Germany
    J Endocrinol 186:377-85. 2005
    Mutations of the human thyrotrophin receptor (TSH-R) are a cause of thyroid adenomas and hyperthyroidism. Here we study mechanisms of receptor activation in a genomic TSH-R variant V509A located in transmembrane helix (TMH) 3, which we ..
  85. pmc Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism
    Ali Cetinkaya
    Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey
    Mediators Inflamm 2005:57-9. 2005
    We aimed to determine whether patients with subclinical hyperthyroidism (SH) are subject to oxidative stress...
  86. doi Effect of hyperthyroidism on clearance and secretion of glucagon in man
    G Dimitriadis
    2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Haidari, Greece
    Exp Clin Endocrinol Diabetes 119:214-7. 2011
    Glucagon has been proposed to contribute to the increased glucose production found in hyperthyroidism. However, fasting plasma glucagon levels are not increased in hyperthyroidism suggesting that the activity of the α-cell is normal...
  87. ncbi Hyperthyroidism and cerebral venous thrombosis
    S Mouton
    Cerebrovascular Disease Center, Lyon, France
    Eur Neurol 54:78-80. 2005
    ..The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII)...
  88. ncbi The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidism
    H Biebermann
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
    J Clin Endocrinol Metab 86:4429-33. 2001
    Sporadic and familial nonautoimmune hyperthyroidism are very rarely occurring diseases. Within the last years constitutively activating TSH receptor mutations were identified as one possible pathomechanism...
  89. ncbi Struma ovarii and hyperthyroidism
    T Dunzendorfer
    Berkshire Physicians and Surgeons, Pittsfield, Massachusetts, 01201, USA
    Thyroid 9:499-502. 1999
    ..Like the cervical thyroid gland, this ectopic thyroid tissue can become autonomous. We present a case of hyperthyroidism caused by thyroid tissue in a large ovarian cystic teratoma and provide detailed endocrinological, ..
  90. ncbi Sleepwalking associated with hyperthyroidism
    Kamel M Ajlouni
    National Center for Diabetes, Endocrinology and Genetics, Amman 11942, Jordan
    Endocr Pract 11:5-10. 2005
    To report several cases of hyperthyroidism in patients presenting with the unusual symptom of sleepwalking and to discuss the possible pathophysiologic basis for this novel association.
  91. ncbi [Hyperthyroidism in the elderly]
    M Simi
    Chirurgia Generale Dipartimento di Chirurgia P Stefanini Università di Roma La Sapienza
    Ann Ital Chir 76:19-22. 2005
    b>Hyperthyroidism in elderly patients is not to be under-evaluated, since it is characterized in such age range by particular clinical and prognostic features...
  92. ncbi Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidism
    Ayse S Cikim
    Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Inonu University, Malatya, Turkey
    Thyroid 14:605-9. 2004
    Subclinical hypothyroidism and subclinical hyperthyroidism are two frequently occurring conditions for which exact therapeutic approaches have not yet been established...
  93. ncbi Hyperplacentosis: a novel cause of hyperthyroidism
    J Ginsberg
    Department of Medicine, University of Alberta, Edmonton, Canada
    Thyroid 11:393-6. 2001
    Human chorionic gonadotropin (hCG), which is capable of thyrotropic activity, is believed responsible for the hyperthyroidism of gestational trophoblastic disease and hyperemesis gravidarum...
  94. ncbi Antioxidants in patients with hyperthyroidism
    Ljiljana Mayer
    Department of Laboratory Medicine, Dubrava University Hospital, Zagreb, Croatia
    Clin Chem Lab Med 42:154-8. 2004
    b>Hyperthyroidism is a hypermetabolic state accompanied by increased oxygen utilization, increased production of reactive oxygen species and consequentially measurable changes in antioxidative factors...
  95. ncbi 5: Diagnosis and management of hyperthyroidism and hypothyroidism
    Duncan J Topliss
    Department of Endocrinology and Diabetes, Alfred Hospital, Melbourne, VIC 3004, Australia
    Med J Aust 180:186-93. 2004
    The most common cause of hyperthyroidism in Australia is Graves disease, caused by a defect in immunoregulation in genetically predisposed individuals, leading to production of thyroid-stimulating antibodies...
  96. ncbi Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases
    Peter Laurberg
    Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Clin Endocrinol Metab 92:2149-56. 2007
    Graves' hyperthyroidism and multinodular toxic goiter lead to high serum T(3) compared with serum T(4). The source of this high T(3) has not been clarified.
  97. ncbi Depression and anxiety in hyperthyroidism
    Mehmet Murat Demet
    Department of Psychiatry, Department of Internal Medicine, Medical Faculty, Celal Bayar University, Manisa, Turkey
    Arch Med Res 33:552-6. 2002
    Our objective was to determine symptomatology of depression and anxiety in patients with untreated hyperthyroidism and compare with euthyroid patients.
  98. ncbi Activating TSH-receptor mutation (Met453Thr) as a cause of adenomatous non-autoimmune hyperthyroidism in a 3-year-old boy
    Sebastian Kraemer
    Department of Paediatric Surgery, University Hospital of Leipzig, Leipzig, Germany
    J Pediatr Endocrinol Metab 22:269-74. 2009
    ..Particularly in children and adolescents, somatic or germ cell mutations may lead to hyperthyroidism. In these cases, molecular analysis of the TSHR gene provides important information for further clinical ..
  99. ncbi Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism
    Maren Claus
    III Medical Department, University of Leipzig, Leipzig, Germany
    Thyroid 15:1089-94. 2005
    Hereditary nonautoimmune hyperthyroidism is caused by activating thyrotropin receptor (TSHR) germline mutations. We describe a family from Saxony, Germany, with this condition...
  100. ncbi Duration of the P wave and P wave dispersion in subclinical hyperthyroidism
    Berrin Cetinarslan
    Department of Endocrinology and Metabolism, University of Kocaeli School of Medicine, Derince, Kocaeli, Turkey 41900
    Endocr Pract 9:200-3. 2003
    ..and adjusted Pdis, which are simple noninvasive electrocardiographic markers to detect paroxysmal atrial fibrillation, differ in patients with endogenous subclinical hyperthyroidism in comparison with those in healthy control subjects.
  101. ncbi Treatment of hyperthyroidism associated with thyrotropin-secreting pituitary adenomas with iopanoic acid
    Kimvir S Dhillon
    Department of Medicine, Division of Endocrinology, and Gonda Diabetes Center, University of California, Los Angeles School of Medicine 90095, USA
    J Clin Endocrinol Metab 89:708-11. 2004
    TSH-secreting tumors comprise less than 2% of all pituitary adenomas. All patients present with hyperthyroidism with a detectable TSH level, and a majority have macroadenomas. Oral cholecystographic agents (e.g...

Research Grants98

  1. Graves' Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Graves'disease (GD) accounts for the vast majority of cases of hyperthyroidism in young adults...
  2. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2010
    ..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
  3. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
  4. GONADOTROPIN ACTION
    William R Moyle; Fiscal Year: 2010
    ..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
  5. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra McLachlan; Fiscal Year: 2009
    ..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
  6. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graves'disease (GD) accounts for the vast majority of cases of hyperthyroidism in young adults...
  7. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The large majority of older patients with autoimmune Graves'hyperthyroidism and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 ..
  8. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
  9. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2010
    ..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
  10. Heart Vascular Function and Thyroid Hormone Receptors
    Wolfgang H Dillmann; Fiscal Year: 2013
    ..b>Hyperthyroidism increases coronary perfusion and enhances cardiac capillary density but these beneficial vascular effects are ..
  11. TSH RECEPTOR MULTIMERIZATION
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
    ..The TSHR is also the major autoantigen in the autoimmune hyperthyroidism known as Graves'disease where T cells and autoantibodies are directed at the TSHR...
  12. TSH and Bone
    Mone Zaidi; Fiscal Year: 2013
    ..potent anti-resorptive and anabolic actions, and that a loss of these actions contributes to the bone loss of hyperthyroidism. We will use genetically modified mice and state-of-the-art molecular approaches to understand the role of ..
  13. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013
    ..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
  14. THE THYROTHROPIN RECEPTOR IN HEALTH AND DISEASE
    Basil Rapoport; Fiscal Year: 2013
    ..In Graves'Disease thyroid-stimulating autoantibodies (TSAb) activate the TSHR and cause hyperthyroidism. Understanding how TSAb and TSH interact with the TSHR extracellular domain and how the TSHR structure ..
  15. Energy Balance and Neurodegenerative Disease
    Robert G Kalb; Fiscal Year: 2013
    ..This can not be attributed to poor nutrition, hyperthyroidism, fever, excessive motor activity or excessive brown fat activity...
  16. Gene Expression in Nonspecific Orbital Inflammatory Disease
    James T Rosenbaum; Fiscal Year: 2011
    ..Several diseases including sarcoidosis, Wegener's granulomatous, Graves'disease (hyperthyroidism) and so called nonspecific orbital inflammatory disease can cause orbital inflammation...
  17. Small molecules and antibodies interacting at the TSH receptor
    TERRY FRANCIS DAVIES; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Graves'disease is a leading cause of hyperthyroidism in the US and worldwide. Anti-thyroid drugs have many side effects and new therapeutics are needed...
  18. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 1999
    ..of the initial events in their actions is important for understanding health-related problems such as hyperthyroidism, precocious puberty, and polycystic ovarian disease...
  19. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 2000
    ..of the initial events in their actions is important for understanding health-related problems such as hyperthyroidism, precocious puberty, and polycystic ovarian disease...
  20. Quantitating Mitophagy in Skeletal Muscle Models
    Edgar A Arriaga; Fiscal Year: 2012
    ..is to apply these bioanalytical approaches to characterize the role of mitophagy in human conditions such as hyperthyroidism and aging that are characterized by alterations in protein turnover...
  21. Quantitating Mitophagy in Skeletal Muscle Models
    Edgar A Arriaga; Fiscal Year: 2012
    ..is to apply these bioanalytical approaches to characterize the role of mitophagy in human conditions such as hyperthyroidism and aging that are characterized by alterations in protein turnover...
  22. Quantitating Mitophagy in Skeletal Muscle Models
    Edgar A Arriaga; Fiscal Year: 2013
    ..is to apply these bioanalytical approaches to characterize the role of mitophagy in human conditions such as hyperthyroidism and aging that are characterized by alterations in protein turnover...
  23. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ..liver coupled with the demonstration that circulating atriopeptin concentrations are elevated in diabetes and hyperthyroidism (conditions associated with elevated gluconeogenic rats), and decreased under conditions when gluconeogenic ..
  24. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1990
    ..liver coupled with the demonstration that circulating atriopeptin concentrations are elevated in diabetes and hyperthyroidism (conditions associated with elevated gluconeogenic rats), and decreased under conditions when gluconeogenic ..
  25. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1980
    ..e. myocardial ischemia, hypertension, hyperthyroidism, digitalis, diuretics, will be investigated...
  26. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2001
    ..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
  27. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 1999
    ..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
  28. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2000
    ..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
  29. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2002
    ..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
  30. PHYSIOLOGICAL ROLE OF THYROXINE BINDING PROTEINS
    PHILIP LARSEN; Fiscal Year: 1991
    ..In addition, we will examine the effects of hypo- and hyperthyroidism (T3 induced) and hypopituitarism on the response of their cells to those hormones...
  31. PHYSIOLOGICAL ROLE OF THYROXINE BINDING PROTEINS
    PHILIP LARSEN; Fiscal Year: 1992
    ..In addition, we will examine the effects of hypo- and hyperthyroidism (T3 induced) and hypopituitarism on the response of their cells to those hormones...
  32. PHYSIOLOGICAL ROLE OF THYROXINE BINDING PROTEINS
    PHILIP LARSEN; Fiscal Year: 1990
    ..In addition, we will examine the effects of hypo- and hyperthyroidism (T3 induced) and hypopituitarism on the response of their cells to those hormones...
  33. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    ..sulfur containing antithyroid drug, induces ANA in over 1/3 of hyperthyroid cats receiving 15mg/day for hyperthyroidism. However, this drug has failed to produce any clinical signs of a lupus-like syndrome...
  34. Binding Determinants of Glycoprotein Hormone Receptors
    J PUETT; Fiscal Year: 2005
    ..Mutations, activating or inactivating GpHR function, have been identified in hyperthyroidism, precocious puberty and pseudohermaphroditism; moreover, polymorphic variants of LH and FSH receptors have ..
  35. Binding Determinants of Glycoprotein Hormone Receptors
    J PUETT; Fiscal Year: 2006
    ..Mutations, activating or inactivating GpHR function, have been identified in hyperthyroidism, precocious puberty and pseudohermaphroditism; moreover, polymorphic variants of LH and FSH receptors have ..
  36. Binding Determinants of Glycoprotein Hormone Receptors
    J PUETT; Fiscal Year: 2007
    ..Mutations, activating or inactivating GpHR function, have been identified in hyperthyroidism, precocious puberty and pseudohermaphroditism; moreover, polymorphic variants of LH and FSH receptors have ..
  37. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2001
    ..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
  38. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2003
    ..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
  39. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2004
    ..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
  40. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2002
    ..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
  41. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2005
    ..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
  42. ROLE OF CATECHOL ESTROGENS IN HYPERTENSION
    Kathleen Shiverick; Fiscal Year: 1980
    ..e. drug interactions, hyperthyroidism and cigarette smoking, for the development of estrogen-induced cardiovascular changes.
  43. MOLECULAR ETIOLOGY OF GRAVES DISEASE
    ROGER CONE; Fiscal Year: 1991
    DESCRIPTION (adapted from the applicant's abstract): Graves' hyperthyroidism is caused by autoantibodies which stimulate the thyroid by binding to and activating the thyroid stimulating hormone receptor (TSH-R)...
  44. THE PSYCHOLOGY AND PHYSIOLOGY OF SLEEP.
    Allan Rechtschaffen; Fiscal Year: 1992
    ..3. To determine whether increased metabolism or other effects of hyperthyroidism increase or decrease survival and other symptoms, thyroxine will be chronically administered to sleep ..
  45. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2000
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  46. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 1999
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  47. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2000
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  48. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2002
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  49. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2001
    ..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
  50. PATHOGENESIS OF HYPERTHYROIDISM
    J MC KENZIE; Fiscal Year: 1980
    Through the efforts of numerous laboratories, including this, the pathogenesis of hyperthyroidism of Graves' disease is now recognized as based on the action of a thyroid-stimulating (auto) antibody, TSAb...
  51. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 2009
    ..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
  52. GONADOTROPIN ACTION
    William Moyle; Fiscal Year: 2007
    ..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
  53. Identifying Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2003
    ..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
  54. Identifying Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2005
    ..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
  55. Identifying Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2004
    ..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
  56. Identifying Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2006
    ..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
  57. Identifying Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2002
    ..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
  58. BEHAVIOR 7 HYPERTHYROIDISM: A (BETA)-ADRENERGIC MECHANIS
    Paula Trzepacz; Fiscal Year: 1990
    We propose to investigate in Graves' disease, the most common type of hyperthyroidism. Our preliminary study used a higher degree of standardization and comprehensiveness than did previous studies...
  59. CONTROL OF MYOSIN TYPES IN INDIVIDUAL MUSCLE FIBERS
    Neal Rubinstein; Fiscal Year: 1993
    ..or symptomotology of muscle diseases such as floppy infant syndrome, respiratory muscle fatigue, or hypo- and hyperthyroidism. Our long term goal is to define the factors controlling expression of MHC isoforms and to investigate hoe ..
  60. CONTROL OF MYOSIN TYPES IN INDIVIDUAL MUSCLE FIBERS
    Neal Rubinstein; Fiscal Year: 1990
    ..or symptomotology of muscle diseases such as floppy infant syndrome, respiratory muscle fatigue, or hypo- and hyperthyroidism. Our long term goal is to define the factors controlling expression of MHC isoforms and to investigate hoe ..
  61. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2002
    Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
  62. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2001
    Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
  63. Subclinical thyroid dysfunction in the elderly
    Anne Cappola; Fiscal Year: 2009
    ..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
  64. MECHANISM OF ACTION OF THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1991
    ..in various tissues, and therefore to understanding the basis for the signs and symptoms of hypothyroidism and hyperthyroidism. Techniques employed to address these questions will include gel shift and avidin biotin complex to DNA ..
  65. MECHANISM OF ACTION OF THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1992
    ..in various tissues, and therefore to understanding the basis for the signs and symptoms of hypothyroidism and hyperthyroidism. Techniques employed to address these questions will include gel shift and avidin biotin complex to DNA ..
  66. MECHANISM OF ACTION OF THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1993
    ..in various tissues, and therefore to understanding the basis for the signs and symptoms of hypothyroidism and hyperthyroidism. Techniques employed to address these questions will include gel shift and avidin biotin complex to DNA ..
  67. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2000
    Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
  68. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
  69. METABOLIC DERANGEMENTS IN THYROID DISEASE
    BRYAN HAUGEN; Fiscal Year: 2000
    ..prospective protocol designed to examine changes in energy expenditure in patients with overt and subclinical hyperthyroidism and hypothyroidism compared to healthy controls...
  70. THYROID GLAND PHYSIOLOGY IN HEALTH AND DISEASE
    INDER CHOPRA; Fiscal Year: 1980
    ..amniotic fluid concentrations of iodothyronines in complicated pregnancy; (4) the usefulness in treatment of hyperthyroidism of agents, e.g...
  71. ANTIGENS AND ANTIBODIES IN GRAVES' OPHTHALMOPATHY
    Jack Wall; Fiscal Year: 1991
    ..and EM shared membrane antigen of 64 kDa which may explain the association of the eye disorder with Graves' hyperthyroidism and, less often, Hashimoto's thyroiditis...
  72. ANTIGENS AND ANTIBODIES IN GRAVES' OPHTHALMOPATHY
    Jack Wall; Fiscal Year: 1992
    ..and EM shared membrane antigen of 64 kDa which may explain the association of the eye disorder with Graves' hyperthyroidism and, less often, Hashimoto's thyroiditis...
  73. ROLE OF THYROID HORMONE IN BROWN ADIPOSE TISSUE FUNCTION
    Jorge Silva; Fiscal Year: 1990
    ..the local mechanisms which can provide sufficient T3 to allow a full thermogenic response without systemic hyperthyroidism. The central question is whether the saturation of T3 receptors during adrenergic stimulation results from ..
  74. The role of chemokines in experimental thyroiditis
    Sergio Lira; Fiscal Year: 2007
    ..of AITD are Hashimoto's thyroiditis (HT), causing hypothyroidism, and Graves' disease (GD), causing hyperthyroidism. The hallmark of these conditions is thyroid dysfunction associated with the presence of lymphocytic ..