Genomes and Genes
Summary: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Publications289 found, 100 shown here
- Prompt treatment of hypothyroidism following radioiodine therapy: impact on thyroid function and mortalityGeorge J Kahaly
Department of Medicine I, Gutenberg University Hospital, Mainz, Germany
Nat Clin Pract Endocrinol Metab 2:134-5. 2006
- [Current thyroid diagnostics and therapy in disorders of fertility and in pregnancy]Heike J Fink
Medizinische Klinik, ,
Med Klin (Munich) 101:645-52; quiz 653-4. 2006
- Thyroid medications during pregnancyThien-Giang Bach-Huynh
Division of Endocrinology and Metabolism, Georgetown University, Suite 232, Bldg. D, 4000 Reservoir Road, NW, Washington, DC 20007, USA
Ther Drug Monit 28:431-41. 2006..Both hypothyroidism and hyperthyroidism should be diagnosed using the appropriate reference intervals for pregnancy...
- Common thyroid disorders. A review of therapiesAnne Marie Liles
University of Mississippi Medical Center, Jackson Mississippi, USA
Adv Nurse Pract 14:29-32; quiz 33. 2006
- Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patientsCesare Carani
Department of Endocrinology, University of Modena, Italy
J Clin Endocrinol Metab 90:6472-9. 2005..PATIENTS: The study included 48 adult men, 34 with hyperthyroidism and 14 with hypothyroidism...
- Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutationsA Hebrant
School of Medicine, Institute of Interdisciplinary Research IRIBHM, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
Eur J Endocrinol 164:1-9. 2011Three syndromes affecting the thyroid gland are described in the literature separately: familial nonautoimmune hyperthyroidism, sporadic congenital nonautoimmune hyperthyroidism, and autonomous adenomas...
- Subclinical hyperthyroidism and pregnancy outcomesBrian M Casey
Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
Obstet Gynecol 107:337-41. 2006Subclinical hyperthyroidism has long-term sequelae that include osteoporosis, cardiovascular morbidity, and progression to overt thyrotoxicosis or thyroid failure...
- Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patientsB Biondi
Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
J Clin Endocrinol Metab 85:4701-5. 2000To determine the clinical impact of endogenous subclinical hyperthyroidism, specific symptoms and signs of thyroid hormone excess and quality of life were assessed in 23 patients (3 males and 20 females; mean age, 43 +/- 9 yr) and 23 age-..
- Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnoverKamal A S Al-Shoumer
Division of Endocrinology and Metabolic Medicine, Mubarak Al-Kabeer Hospital, Jabriya, and the Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
Endocr Pract 12:121-30. 2006OBJECTIVE: To study glucose and bone metabolism in hyperthyroidism, assess their changes after treatment, and investigate their interrelationships...
- Insulin resistance in hyperthyroidism: the role of IL6 and TNF alphaPanayota Mitrou
Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
Eur J Endocrinol 162:121-6. 2010Although insulin resistance is a common finding in hyperthyroidism, the implicated mechanisms are obscure...
- Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidismAlev E Altinova
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
Clin Endocrinol (Oxf) 65:530-5. 2006..The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction...
- Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidismC Rochon
, INRA Centre de Clermont-Ferrand, , France
Clin Sci (Lond) 104:7-15. 2003..thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps...
- Studies of insulin resistance in patients with clinical and subclinical hyperthyroidismEirini Maratou
Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications HNDC, Athens, Greece
Eur J Endocrinol 163:625-30. 2010Although clinical hyperthyroidism (HR) is associated with insulin resistance, the information on insulin action in subclinical hyperthyroidism (SHR) is limited.
- The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidismA S R Araujo
Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050 170 Porto Alegre, RS, Brazil
J Mol Endocrinol 41:423-30. 2008..protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were divided into four groups: control, vitamin E, thyroxine (T(4)), and T(4)+vitamin E...
- Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in miceYumiko Mizutori
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
J Autoimmun 26:32-6. 2006..injected with dendritic cells (DCs) infected with adenovirus encoding the full-length TSHR (AdTSHR) develop hyperthyroidism, albeit at a low incidence (36%)...
- Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidismL Duprez
Institut de Recherche Interdisciplinaire, Faculty of Medicine, University of Brussels, Belgium
Nat Genet 7:396-401. 1994..mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) ..
- Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort studyHenry Volzke
SHIP Clinical Epidemiological Research Unit, Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
Eur J Endocrinol 161:615-21. 2009There is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet...
- Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid anginaRupa Patel
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9066, USA
Thyroid 18:273-6. 2008..Subsequently, she was diagnosed with hyperthyroidism and treated with antithyroid therapy and oral nitrates...
- Glucose and lipid fluxes in the adipose tissue after meal ingestion in hyperthyroidismGeorge Dimitriadis
Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Attikon University Hospital, 1 Rimini Street, GR 12462 Haidari, Greece
J Clin Endocrinol Metab 91:1112-8. 2006Although insulin resistance is well established in hyperthyroidism, information on the effects of insulin on adipose tissue (AD) is limited.
- Subclinical hyperthyroidism as a risk factor for atrial fibrillationJ Auer
Division of Cardiology and Intensive Care, Department of Internal Medicine II, General Hospital Wels, Wels, Austria
Am Heart J 142:838-42. 2001Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically ..
- Plasma levels of coenzyme Q10 in children with hyperthyroidismThomas Menke
Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Dr Friedrich Steiner Strasse 5, DE 45711 Datteln, Germany
Horm Res 61:153-8. 2004In hyperthyroidism, increased oxygen consumption and free radical production in the stimulated respiratory chain leads to oxidative stress...
- Evaluation of oxidative status in patients with hyperthyroidismMehmet Aslan
Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey
Endocrine 40:285-9. 2011Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism...
- Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiterC Huel
Department of Perinatology, Robert Debre Hospital, Paris, France
Ultrasound Obstet Gynecol 33:412-20. 2009To determine whether sonography can be used to distinguish hyperthyroidism from hypothyroidism in pregnancies with fetal goiter.
- Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programmePernille Vejbjerg
Department of Endocrinology and Gastroenterology, Bispebjerg University Hospital, Copenhagen, Denmark
Clin Endocrinol (Oxf) 71:440-5. 2009..We evaluated the influence of a higher iodine intake on thyroid hormone levels and the prevalence of thyroid dysfunction in the Danish population...
- Hyperplacentosis: a novel cause of hyperthyroidismJ Ginsberg
Department of Medicine, University of Alberta, Edmonton, Canada
Thyroid 11:393-6. 2001Human chorionic gonadotropin (hCG), which is capable of thyrotropic activity, is believed responsible for the hyperthyroidism of gestational trophoblastic disease and hyperemesis gravidarum...
- Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidismAli Cetinkaya
Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey
Mediators Inflamm 2005:57-9. 2005We aimed to determine whether patients with subclinical hyperthyroidism (SH) are subject to oxidative stress...
- Dietary-induced hyperthyroidism marginally affects neonatal testicular developmentEddy Rijntjes
Department of Animal Sciences, Human and Animal Physiology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
J Androl 29:643-53. 2008The objective of this study was to determine whether dietary-induced mild fetal/neonatal hyperthyroidism influenced the initiation of spermatogenesis and the development of the adult-type Leydig cell population...
- An activating mutation of the thyrotropin receptor gene in hereditary non-autoimmune hyperthyroidismYung Seng Lee
Department of Paediatrics, National University of Singapore
J Pediatr Endocrinol Metab 15:211-5. 2002..a germline activating mutation M463V of the TSH receptor gene in two siblings with hereditary non-autoimmune hyperthyroidism. The onset of disease in the affected members of the pedigree occurred during childhood or adolescence...
- Serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid functionChing Jung Hsieh
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Endocr J 55:489-94. 2008..The aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication...
- Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activityCihangir Erem
Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Trabzon, Turkey
Clin Endocrinol (Oxf) 64:323-9. 2006..On the other hand, subclinical hyperthyroidism (SCHyper) is associated with enhanced cardiovascular risk...
- Thyroid disorders. Part I: hyperthyroidismJames W Little
University of Minnesota, Minneapolis, Minnesota, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:276-84. 2006..This article (part I) deals with hyperthyroidism, part II with hypothyroidism and thyroiditis, and part III with neoplastic lesions of the thyroid...
- Myocardial antioxidant enzyme activities and concentration and glutathione metabolism in experimental hyperthyroidismA S R Araujo
Departamento Fisiologia, , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Mol Cell Endocrinol 249:133-9. 2006b>Hyperthyroidism was induced in rats by l-thyroxine administration (12 mg/L in drinking water, 4 weeks). Animals were assessed hemodynamically, and heart, lung, and liver morphometry were performed...
- Duration of the P wave and P wave dispersion in subclinical hyperthyroidismBerrin Cetinarslan
Department of Endocrinology and Metabolism, University of Kocaeli School of Medicine, Derince, Kocaeli, Turkey 41900
Endocr Pract 9:200-3. 2003..markers to detect paroxysmal atrial fibrillation, differ in patients with endogenous subclinical hyperthyroidism in comparison with those in healthy control subjects...
- Treatment of hyperthyroidism associated with thyrotropin-secreting pituitary adenomas with iopanoic acidKimvir S Dhillon
Department of Medicine, Division of Endocrinology, and Gonda Diabetes Center, University of California, Los Angeles School of Medicine 90095, USA
J Clin Endocrinol Metab 89:708-11. 2004TSH-secreting tumors comprise less than 2% of all pituitary adenomas. All patients present with hyperthyroidism with a detectable TSH level, and a majority have macroadenomas. Oral cholecystographic agents (e.g...
- 5: Diagnosis and management of hyperthyroidism and hypothyroidismDuncan J Topliss
Department of Endocrinology and Diabetes, Alfred Hospital, Melbourne, VIC 3004, Australia
Med J Aust 180:186-93. 2004The most common cause of hyperthyroidism in Australia is Graves disease, caused by a defect in immunoregulation in genetically predisposed individuals, leading to production of thyroid-stimulating antibodies...
- Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimesterMuhieddine Seoud
Obstetrics and Gynecology, The American University of Beirut Medical Center, New York, New York 10022, USA
Am J Perinatol 20:59-62. 2003..Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.
- Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinasesPeter Laurberg
Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
J Clin Endocrinol Metab 92:2149-56. 2007Graves' hyperthyroidism and multinodular toxic goiter lead to high serum T(3) compared with serum T(4). The source of this high T(3) has not been clarified.
- Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidismAziz Yazar
Department of Internal Medicine, Mersin University Medical School, Mersin, Turkey
Arch Med Res 34:35-40. 2003The aim of this study was to investigate systolic pulmonary artery pressure (SPAP) and serum uric acid (SUA) levels in patients with hyperthyroidism and after euthyroid state was reached.
- Hyperthyroidism: a rare cause of reversible pulmonary hypertensionRock Wasseem
Department of Internal Medicine C, Hae'meK Medical Center, Afula 18101, Israel
Am J Med Sci 332:140-1. 2006..Possible mechanisms for the development of pulmonary arterial hypertension due to hyperthyroidism include damage to pulmonary vascular endothelium due to high cardiac output or an autoimmune process or ..
- Depression and anxiety in hyperthyroidismMehmet Murat Demet
Department of Psychiatry, Department of Internal Medicine, Medical Faculty, Celal Bayar University, Manisa, Turkey
Arch Med Res 33:552-6. 2002Our objective was to determine symptomatology of depression and anxiety in patients with untreated hyperthyroidism and compare with euthyroid patients.
- Antioxidants in patients with hyperthyroidismLjiljana Mayer
Department of Laboratory Medicine, Dubrava University Hospital, Zagreb, Croatia
Clin Chem Lab Med 42:154-8. 2004b>Hyperthyroidism is a hypermetabolic state accompanied by increased oxygen utilization, increased production of reactive oxygen species and consequentially measurable changes in antioxidative factors...
- Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in ratsIsabel Rodriguez-Gomez
Departamento de Fisiologia, Facultad de Medicina, Granada, Spain
Am J Hypertens 21:341-7. 2008..chronic administration of clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on the development and established hemodynamic, morphologic, metabolic, and renal manifestations of hyperthyroidism in rats.
- Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysisJennifer P Holst
Georgetown University Washington Hospital Center, Washington, DC, USA
Thyroid 15:1321-31. 2005Treatment with radioactive iodine ((131)I) may be necessary for thyroid cancer or for hyperthyroidism in patients with end-stage renal disease who require hemodialysis...
- A novel TSHR gene mutation (Ile691Phe) in a Chinese family causing autosomal dominant non-autoimmune hyperthyroidismZheng Liu
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
J Hum Genet 53:475-8. 2008Familial non-autoimmune hyperthyroidism is a rare autosomal dominant genetic disease resulting from activating mutations in the thyroid-stimulating hormone receptor (TSHR) gene...
- Endothelial dysfunction in subjects with subclinical hyperthyroidismE Coban
Department of Internal Medicine, Akdeniz University Faculty of Medicine, 07070 Antalya, Turkey
J Endocrinol Invest 29:197-200. 2006..9+/-9.6 vs 37.6+/-6.4%, p=0.026). In conclusion, our results suggest that subjects with subclinical hyperthyroidism tend to have an endothelial dysfunction...
- Hyperthyroidism with fibrous dysplasia: an unusual presentation of McCune-Albright syndromeM H Bhat
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Exp Clin Endocrinol Diabetes 115:331-3. 2007..b>Hyperthyroidism as a manifestation of endocrine hyperfunction in MAS is uncommon...
- The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidismH Biebermann
Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
J Clin Endocrinol Metab 86:4429-33. 2001Sporadic and familial nonautoimmune hyperthyroidism are very rarely occurring diseases. Within the last years constitutively activating TSH receptor mutations were identified as one possible pathomechanism...
- Increased risk of affective disorder following hospitalisation with hyperthyroidism - a register-based studyAnders F Thomsen
Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Denmark
Eur J Endocrinol 152:535-43. 2005..We assessed whether hospitalisation with hyperthyroidism was a risk factor for hospitalisation with affective disorder and evaluated the temporal relationship between ..
- Pregnancy complicated with pulmonary edema due to hyperthyroidismMing Jie Yang
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
J Chin Med Assoc 68:336-8. 2005b>Hyperthyroidism is one of the most common causes of cardiac failure. Blood volume expands greatly during pregnancy, especially after the last part of the second trimester...
- Prospective echocardiographic evaluation of patients with endogenous subclinical hyperthyroidism and after restoring euthyroidismGrzegorz Kaminski
Departments of Endocrinology and Isotope Therapy Internal Medicine and Cardiology Nuclear Medicine, Military Institute of Medicine, Szaserów St 128, Warsaw, Poland
Clin Endocrinol (Oxf) 74:501-7. 2011Clinical significance of, and the need for, treatment in subclinical hyperthyroidism (sHT) is still a matter of debate. The aim of the study was to assess the impact of sHT on echocardiographic parameters.
- Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemmaBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Eur J Endocrinol 162:587-9. 2010The association of endogenous subclinical hyperthyroidism (SHyper) with cardiovascular mortality is controversial...
- Outcomes of pregnancy complicated with hyperthyroidism: a cohort studySuchaya Luewan
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Arch Gynecol Obstet 283:243-7. 2011To determine maternal and fetal outcomes of women complicated with hyperthyroidism compared with those in normal pregnant women.
- TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5Beate Karges
Pediatric Endocrinology, University Children s Hospital, University of Ulm, Prittwitzstrasse 43, D 89075 Ulm, Germany
J Endocrinol 186:377-85. 2005Mutations of the human thyrotrophin receptor (TSH-R) are a cause of thyroid adenomas and hyperthyroidism. Here we study mechanisms of receptor activation in a genomic TSH-R variant V509A located in transmembrane helix (TMH) 3, which we ..
- Hyperthyroidism, exophthalmos, and goiter: historical notes on the orbitopathyJorgen Lindholm
Department of Endocrinology, Aarhus University Hospital, Aalborg, Denmark
Thyroid 20:291-300. 2010Exophthalmos associated with goiter and/or symptoms of hyperthyroidism have been known since antiquity. It was not until around 1800 that a number of studies described this disorder in more detail.
- Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred miceB Rapoport
Cedars Sinai Research Institute and UCLA School of Medicine, Los Angeles, CA 90048, USA
Genes Immun 11:254-63. 2010Graves' hyperthyroidism is an autoimmune disease occurring spontaneously in humans and caused by autoantibodies that stimulate the thyrotropin receptor...
- The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidismThenmalar Vadiveloo
Division of Clinical and Population Sciences and Education, University of Dundee, Dundee, Scotland, United Kingdom
J Clin Endocrinol Metab 96:E1-8. 2011For patients with subclinical hyperthyroidism (SH), the objective of the study was to define the rates of progression to frank hyperthyroidism and normal thyroid function.
- Body weight and body composition changes after treatment of hyperthyroidismL Lonn
Department of Radiology, Sahlgrenska University Hospital, University of Goteborg, Sweden
J Clin Endocrinol Metab 83:4269-73. 1998Body composition changes in nine adults with hyperthyroidism were determined with dual energy x-ray absorptiometry and computed tomography at diagnosis and after 3 and 12 months of euthyroidism achieved by surgery, antithyroid drugs, or ..
- Struma ovarii and hyperthyroidismT Dunzendorfer
Berkshire Physicians and Surgeons, Pittsfield, Massachusetts, 01201, USA
Thyroid 9:499-502. 1999..Like the cervical thyroid gland, this ectopic thyroid tissue can become autonomous. We present a case of hyperthyroidism caused by thyroid tissue in a large ovarian cystic teratoma and provide detailed endocrinological, ..
- A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6Franziska Winkler
Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
J Clin Endocrinol Metab 95:3605-10. 2010Activating mutations in the TSHR gene were found in patients suffering from nonautoimmune hyperthyroidism. In the past, it was assumed that thyroid hyperplasia is due to constitutive activation of the Gs/adenylyl cyclase signaling ..
- Hyperthyroidism and cerebral venous thrombosisS Mouton
Cerebrovascular Disease Center, Lyon, France
Eur Neurol 54:78-80. 2005..The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII)...
- Insulin action in hyperthyroidism: a focus on muscle and adipose tissuePanayota Mitrou
Hellenic National Center for Research, Prevention, and Treatment of Diabetes Mellitus and Its Complications, 10675 Athens, Greece
Endocr Rev 31:663-79. 2010b>Hyperthyroidism leads to an enhanced demand for glucose, which is primarily provided by increased rates of hepatic glucose production due to increased gluconeogenesis (in the fasting state) and increased Cori cycle activity (in the late ..
- [Hyperthyroidism in the elderly]M Simi
Ann Ital Chir 76:19-22. 2005b>Hyperthyroidism in elderly patients is not to be under-evaluated, since it is characterized in such age range by particular clinical and prognostic features...
- Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidismMaren Claus
III. Medical Department, University of Leipzig, Leipzig, Germany
Thyroid 15:1089-94. 2005OBJECTIVE: Hereditary nonautoimmune hyperthyroidism is caused by activating thyrotropin receptor (TSHR) germline mutations. We describe a family from Saxony, Germany, with this condition...
- Activating TSH-receptor mutation (Met453Thr) as a cause of adenomatous non-autoimmune hyperthyroidism in a 3-year-old boySebastian Kraemer
Department of Paediatric Surgery, University Hospital of Leipzig, Leipzig, Germany
J Pediatr Endocrinol Metab 22:269-74. 2009..Particularly in children and adolescents, somatic or germ cell mutations may lead to hyperthyroidism. In these cases, molecular analysis of the TSHR gene provides important information for further clinical ..
- Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidismAyse S Cikim
Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Inonu University, Malatya, Turkey
Thyroid 14:605-9. 2004Subclinical hypothyroidism and subclinical hyperthyroidism are two frequently occurring conditions for which exact therapeutic approaches have not yet been established...
- Is hyperthyroidism underestimated in pregnancy and misdiagnosed as hyperemesis gravidarum?Ana Tikvica Luetic
Department of Obstetrics and Gynecology, General Hospital Sveti Duh, Sveti Duh 64, 10 000 Zagreb, Croatia
Med Hypotheses 75:383-6. 2010..However, hyperthyroidism occurs in pregnancy with clinical presentation similar to hyperemesis gravidarum (HG) and pregnancy itself...
- Experimental hyperthyroidism-induced oxidative stress and impairment of antioxidant defence system in rat testisDipak K Sahoo
Department of Biotechnology, Utkal University, Bhubaneswar 7510 04, India
Indian J Exp Biol 43:1058-67. 2005Short-term hyperthyroidism, induced by daily administration of T3 (20 microg/100g body weight) for one, three, and five days consecutively, modulates oxidative stress and antioxidant defence parameters in mitochondrial and ..
- Sleepwalking associated with hyperthyroidismKamel M Ajlouni
National Center for Diabetes, Endocrinology and Genetics, Amman 11942, Jordan
Endocr Pract 11:5-10. 2005OBJECTIVE: To report several cases of hyperthyroidism in patients presenting with the unusual symptom of sleepwalking and to discuss the possible pathophysiologic basis for this novel association...
- Effect of hyperthyroidism on clearance and secretion of glucagon in manG Dimitriadis
2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Haidari, Greece
Exp Clin Endocrinol Diabetes 119:214-7. 2011Glucagon has been proposed to contribute to the increased glucose production found in hyperthyroidism. However, fasting plasma glucagon levels are not increased in hyperthyroidism suggesting that the activity of the α-cell is normal...
- A case of transient central hyperthyroidismGholam Reza Pishdad
Department of Internal Medicine, Section of Endocrinology and Metabolism, Shiraz University of Medical Sciences, Shiraz, Iran
Med Sci Monit 12:CS103-5. 2006Thionamides are the main therapeutic arsenal for treating hyperthyroidism. Perhaps the first case of a patient who developed a transient pituitary hyperthyroidism after discontinuation of a lengthy intake of a thionamide is reported.
- Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer: a retrospective analysis of seventy-three patientsDaniela Alterio
Division of Radiation Therapy, European Institute of Oncology, Milan, Italy
Int J Radiat Oncol Biol Phys 67:144-50. 2007..To evaluate the incidence of thyroid disorders and dose distribution to the thyroid in patients treated with radiotherapy for head-and-neck carcinomas...
- Thyroid hormone increases mannan-binding lectin levelsAnne Lene Dalkjaer Riis
Medical Department M, Aarhus University Hospital, Denmark
Eur J Endocrinol 153:643-9. 2005..Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields...
- Prenatal thyroid dysfunction: unmasking a significant threat to mother and babyBeth Hassel
Associates for Women's Health, West Reading, PA, USA
Adv Nurse Pract 13:41-4. 2005
- Detecting thyroid diseaseSusan Simmons Holcomb
Sastun Center of Integrative Health Care, Mission, KS, USA
Nursing 35:4-8; quiz 8-9. 2005
- Prevalence of thyroid dysfunction in patients with acute atrial fibrillation attended at a cardiology emergency roomJuarez Neuhaus Barbisan
, Porto Alegre, Rio Grande do Sul, Brazil
Sao Paulo Med J 121:159-62. 2003..RESULTS: Among these patients, 16.6% had altered thyroid function tests: 6.9% had hyperthyroidism, 5.6% hypothyroidism and 4.2% had increased T4 levels, by means of amiodarone use...
- N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) in different thyroid function statesMarianne Schultz
Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark
Clin Endocrinol (Oxf) 60:54-9. 2004..CONCLUSIONS: Serum NT-pro-BNP levels are affected by thyroid function. This seems due to a direct stimulatory effect of thyroid hormones...
- Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctionsF Santini
Department of Endocrinology, University of Pisa, Pisa, Italy
J Endocrinol Invest 27:RC5-7. 2004..We studied 15 patients with hyperthyroidism, 15 patients with hypothyroidism and 15 euthyroid subjects, all matched by sex, age and body mass index (BMI)...
- Influence of chronically altered thyroid status on the activity of liver mitochondrial glycerol-3-phosphate dehydrogenase in female inbred lewis ratsH Rauchova
Institute of Physiology, Academy of Sciences of the Czech Republic
Horm Metab Res 36:286-90. 2004..We conclude that the level of the rat liver GPDH activity could serve as a useful marker for evaluation of hyperthyroid and hypothyroid status in chronic long-lasting experiments on female inbred Lewis rats...
- TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patientsAysin Oge
Department of Internal Medicine, Division of Endocrinology and Metabolism, Adnan Menderes University School of Medicine, Aydin, Turkey
Endocr J 52:213-7. 2005..between thyroid hormones and leptin levels was investigated in patients with overt hypothyroidism and hyperthyroidism before and after successful treatment...
- Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytesE Mezosi
Divisions of Endocrinology and Metabolism, First Department of Medicine, University of Debrecen, Hungary
J Endocrinol 185:121-9. 2005..These results suggest the existence of a membrane-bound binding site for thyroid hormone in PMNLs and a physiological role for thyroid hormone in the cellular defence mechanisms by stimulating free-radical production...
- Thyroid disease in pregnancy and childhoodJ H Lazarus
Cardiff University School of Medicine, Centre for Endocrine and Diabetes Sciences, Academic Centre, Llandough Hospital, Llandough, Cardiff, UK
Minerva Endocrinol 30:71-87. 2005..While hyperthyroidism in pregnancy is uncommon, effects on both mother and child are critical if untreated...
- Correlation between severity of thyroid dysfunction and renal functionJan G den Hollander
Department of Internal Medicine, Medical Centre Rotterdam Zuid, Groene Hilledijk 315, 3075 EA Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 62:423-7. 2005..the relationship between renal function and thyroid status before and after treatment for hypothyroidism and hyperthyroidism, respectively...
- Thyroid function and mortality in patients treated for hyperthyroidismJayne A Franklyn
Division of Medical Sciences, University of Birmingham, England
JAMA 294:71-80. 2005CONTEXT: Hyperthyroidism has been reported to cause excess all-cause and circulatory mortality. Whether this can be reversed is unknown, as is the influence of mild persisting thyroid dysfunction and treatment-induced hypothyroidism...
- [Effects of thyroid disorders on the bone]Peter Mikosch
2 Medizinische Abteilung, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria
Wien Med Wochenschr 155:444-53. 2005..In subclinical hyperthyroidism, premenopausal women show no significant BMD loss, whereas postmenopausal women face a significant BMD loss...
- Antithyroid drugsDavid S Cooper
Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore 21215, USA
N Engl J Med 352:905-17. 2005
- Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective studyClaudia Ceccarelli
Department of Endocrinology, University of Pisa, Opsedale Cisanello, Pisa, Italy
Clin Endocrinol (Oxf) 62:331-5. 2005..To investigate the risk of hypothyroidism after radioiodine (131I) treatment for hyperfunctioning thyroid nodules...
- Effective methimazole dose for childhood Graves' disease and use of free triiodothyronine combined with concurrent thyroid-stimulating hormone level to identify mild hyperthyroidism and delayed pituitary recoveryArnold H Slyper
Department of Pediatrics, Loyola University Medical Center, Maywood, IL 60153, USA
J Pediatr Endocrinol Metab 18:597-602. 2005..025). During treatment, 63.3% of diagnosable samples showed unambiguous hyperthyroidism or triiodothyronine (T3) toxicosis, 16...
- The hypothalamic-pituitary-thyroid axis in subjects with subclinical thyroid diseases: the impact of the negative feedback mechanismPaolo Falaschi
Chair of Internal Medicine, I and II Faculty of Medicine, University of Rome, La Sapienza, Italy
Neuro Endocrinol Lett 25:292-6. 2004....
- Advances in assessment, diagnosis, and treatment of hyperthyroidism in childrenKim Siarkowski Amer
Department of Nursing, DePaul University, Chicago, IL 60614, USA
J Pediatr Nurs 20:119-26. 2005..This article will review common challenges in the diagnosis of hyperthyroidism in children, the approaches to treatment, and the nursing interventions guided toward child and family ..
- [Screening for thyroid disorders in elderly patients]Roberto Torre
UO Medicina Interna, Ospedale S Nicolò, Levanto
Recenti Prog Med 95:308-11. 2004..9% sub-clinical hypothyroidism, 5.4% hypothyroidism secondary to hypopituitarism), 15.6% by hyperthyroidism (overt 7.8% , subclinical 7.8%), and 39.4% showed a low T3 syndrome...
- Is long-term methimazole therapy as effective as radioiodine for treating hyperthyroidism?Anthony D Toft
Royal Infirmary of Edinburgh, UK
Nat Clin Pract Endocrinol Metab 1:14-5. 2005
- Induction of autoimmune hypothyroidism and subsequent hyperthyroidism by TSH receptor antibodies following subacute thyroiditis: a case reportM Iitaka
Fourth Department of Internal Medicine, Saitama Medical School, Japan
Endocr J 48:139-42. 2001..This case indicates that subacute thyroiditis can induce thyroid autoimmunity, and that the character of TSH receptor antibodies (TSHRAb) in these patients can change thereby modifying their thyroid function...
- Radioiodine therapy of thyroid autonomyChristoph Reiners
Clinic and Policlinic for Nuclear Medicine, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Eur J Nucl Med Mol Imaging 29:S471-8. 2002..Therapy-related risks, such as immunogenic hypothyroidism or thyroid cancer, are discussed. (131)I treatment of functional autonomy and hyperthyroidism is considered an effective and safe procedure.
- Thyroid disorders in children from birth to adolescenceMarkus Bettendorf
Universitatsklinikum Heidelberg, Kinderklinik und Poliklinik, Abteilung Allgemeine Kinderheilkunde, Sektion für Stoffwechsel und Endokrinologie, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
Eur J Nucl Med Mol Imaging 29:S439-46. 2002..Therefore, as well as reviewing distinct features of disorders with hypothyroidism, hyperthyroidism and normal thyroid function in childhood and adolescence, this article will also focus on important aspects ..
- Thyroid function and intellectual development of children of mothers taking methimazole during pregnancyF Azizi
The Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, IR, Iran
J Endocrinol Invest 25:586-9. 2002..No deleterious effect occurred in thyroid function and physical and intellectual development of children whose mothers were treated during pregnancy with doses of MMI up to 20 mg daily...
- Hypoechoic thyroid nodules on ultrasound 4 years after prenatal exposure to radioiodine: resolution with thyroxine therapyRebecca J Perry
Department of Child Health, Royal Hospital for Sick Children, Glasgow, UK
Acta Paediatr 97:509-12. 2008..His mother had received 400 MBq of (131)I for hyperthyroidism (total T4 178 nmol/L, thyroid stimulating hormone (TSH) <0.1 mU/L, 4-h (131)I uptake 16%)...
- Effects of thyroxine supplement on serum insulin-like growth factor-binding activity in propylthiouracil induced hypothyroid cockerelsD Morishita
Faculty of Bioresources, Mie University, Tsu, Japan
Horm Metab Res 25:407-10. 1993....
- Thyroid function in breast-fed infants whose mothers take high doses of methimazoleF Azizi
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I R Iran
J Endocrinol Invest 25:493-6. 2002..03, 0.034 and 0.035 microg/ml in the other 3 infants. We conclude that the treatment of hyperthyroid lactating mothers with doses of 20-30 mg MMI day does not cause deleterious effects on thyroid function of their breast-fed infants...
- Serum leptin concentrations of patients with sequential thyroid function changesChing-Jung Hsieh
Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
Clin Endocrinol (Oxf) 57:29-34. 2002..47 units when serum FT4 was increased by one unit. CONCLUSION: In conclusion, our data indicate that circulating thyroid hormone plays a relevant role in regulating leptin metabolism independent of BMI and body fat...
- A case of TSH receptor antibody-positive hyperthyroidism with functioning metastases of thyroid carcinomaTakashi Ishihara
Department of Endocrinology, Kobe City General Hospital, Japan
Endocr J 49:241-5. 2002The presence of TSH receptor antibody (TRAb) is rarely responsible for hyperthyroidism due to metastatic lesions of thyroid carcinoma...
- Thyroid function disorders--Guidelines of the Netherlands Association of Internal MedicineA F Muller
Diakonessenhuis Utrecht, Utrecht, The Netherlands
Neth J Med 66:134-42. 2008..In this manuscript we have aimed to provide the practicing internist with practical and 'as evidence-based as possible' treatment guidelines with respect to thyroid function disorders...
- Graves' Disease Therapy Risks to Mother and FetusScott A Rivkees; Fiscal Year: 2010Graves'disease (GD) accounts for the vast majority of cases of hyperthyroidism in young adults...
- GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICESandra M McLachlan; Fiscal Year: 2010Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
- ANIMAL MODELS OF HYPERTHYROIDISMSandra M McLachlan; Fiscal Year: 2010..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
- GONADOTROPIN ACTIONWilliam R Moyle; Fiscal Year: 2010..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
- ANIMAL MODELS OF HYPERTHYROIDISMSandra McLachlan; Fiscal Year: 2009..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce ..
- NADPH P450 REDUCTASE--THYROID HORMONE REGULATIONDavid Waxman; Fiscal Year: 2002..regulatory mechanisms by which thyroid hormone modulates P450 reductase expression under conditions of hyperthyroidism and hyperthyroidism, and to evaluate the implications of this modulation for P450 reductase-catalyzed quinone ..
- PHYSIOLOGICAL ROLE OF THYROXINE BINDING PROTEINSPHILIP LARSEN; Fiscal Year: 1992..In addition, we will examine the effects of hypo- and hyperthyroidism (T3 induced) and hypopituitarism on the response of their cells to those hormones...
- Binding Determinants of Glycoprotein Hormone ReceptorsJ PUETT; Fiscal Year: 2007..Mutations, activating or inactivating GpHR function, have been identified in hyperthyroidism, precocious puberty and pseudohermaphroditism; moreover, polymorphic variants of LH and FSH receptors have ..
- PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSIONPHILIP LARSEN; Fiscal Year: 2005..for the myocardial response of the euthyroid heart to the thyrotoxic state such as occurs in patients with hyperthyroidism. We have developed a novel method for inducing chronic myocardial thyrotoxicosis in mice by use of a ..
- COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONERonald Cohen; Fiscal Year: 2002..hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism. Moreover, an understanding of how TRs regulate gene transcription in the absence of ligand will provide ..
- GONADOTROPIN ACTIONWilliam Moyle; Fiscal Year: 2007..Efforts to design hormone agonists and antagonists useful for treating infertility and hyperthyroidism would benefit from a molecular understanding of hormone-receptor interaction...
- Identifying Genes Linked to Autoimmune Thyroid DiseasesYaron Tomer; Fiscal Year: 2006..Hashimoto's thyroiditis (HT), which manifests by hypothyroidism, and Graves disease (GD), which causes hyperthyroidism. The mechanisms initiating the AITD are not completely understood...
- MECHANISM OF ACTION OF THYROID HORMONE RECEPTORSRONALD KOENIG; Fiscal Year: 1993..in various tissues, and therefore to understanding the basis for the signs and symptoms of hypothyroidism and hyperthyroidism. Techniques employed to address these questions will include gel shift and avidin biotin complex to DNA ..
- Subclinical thyroid dysfunction in the elderlyAnne R Cappola; Fiscal Year: 2010..Our central hypothesis is that older individuals with persistent subclinical hyperthyroidism are at increased risk for specific adverse cardiovascular, musculoskeletal, and neurocognitive outcomes, ..
- EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASEBellur Prabhakar; Fiscal Year: 2003Autoantibodies to the thyrotropin receptor can either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism...
- The role of chemokines in experimental thyroiditisSergio Lira; Fiscal Year: 2007..forms of AITD are Hashimoto's thyroiditis (HT), causing hypothyroidism, and Graves' disease (GD), causing hyperthyroidism. The hallmark of these conditions is thyroid dysfunction associated with the presence of lymphocytic ..