ovarian hyperstimulation syndrome

Summary

Summary: A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.

Top Publications

  1. doi Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT)
    Trifon G Lainas
    Eugonia Iatriki Erevna IVF Center, Athens, Greece
    Hum Reprod 25:683-9. 2010
  2. doi An OHSS-Free Clinic by segmentation of IVF treatment
    Paul Devroey
    Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod 26:2593-7. 2011
  3. doi Preventing ovarian hyperstimulation syndrome: guidance for the clinician
    Peter Humaidan
    The Fertility Clinic, Skive Regional Hospital, Skive, Denmark
    Fertil Steril 94:389-400. 2010
  4. ncbi Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles
    Tsung Hsien Lee
    Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Hum Reprod 23:160-7. 2008
  5. ncbi Management of severe early ovarian hyperstimulation syndrome by re-initiation of GnRH antagonist
    T G Lainas
    Eugonia Iatriki Erevna IVF Unit, 7 Ventiri str, 11528, Athens, Greece
    Reprod Biomed Online 15:408-12. 2007
  6. doi The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives
    Peter Humaidan
    The Fertility Clinic, Odense University Hospital, Odense, Denmark
    Reprod Biomed Online 24:134-41. 2012
  7. doi IVF outcome in women with PCOS, PCO and normal ovarian morphology
    Alexander Swanton
    Royal Berkshire Hospital, Reading, RG1 5AN, UK
    Eur J Obstet Gynecol Reprod Biol 149:68-71. 2010
  8. ncbi Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study
    Jiann Loung Hwang
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hum Reprod 19:1993-2000. 2004
  9. doi Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis
    Mohamed A F M Youssef
    Department of Obstetrics and Gynaecology, Cairo University, Cairo, Egypt
    Hum Reprod Update 16:459-66. 2010
  10. doi Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination
    Hang Wun Raymond Li
    Centre of Assisted Reproduction and Embryology, Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Fertil Steril 94:2177-81. 2010

Detail Information

Publications288 found, 100 shown here

  1. doi Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT)
    Trifon G Lainas
    Eugonia Iatriki Erevna IVF Center, Athens, Greece
    Hum Reprod 25:683-9. 2010
    Women with polycystic ovary syndrome (PCOS) are at risk of developing ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation...
  2. doi An OHSS-Free Clinic by segmentation of IVF treatment
    Paul Devroey
    Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod 26:2593-7. 2011
    Published data indicate a significant increase in ovarian hyperstimulation syndrome globally...
  3. doi Preventing ovarian hyperstimulation syndrome: guidance for the clinician
    Peter Humaidan
    The Fertility Clinic, Skive Regional Hospital, Skive, Denmark
    Fertil Steril 94:389-400. 2010
    To reevaluate ovarian hyperstimulation syndrome (OHSS) prevention techniques and provide a classification system for grading OHSS and evidence-based treatment strategies for preventing OHSS.
  4. ncbi Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles
    Tsung Hsien Lee
    Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Hum Reprod 23:160-7. 2008
    ..The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols.
  5. ncbi Management of severe early ovarian hyperstimulation syndrome by re-initiation of GnRH antagonist
    T G Lainas
    Eugonia Iatriki Erevna IVF Unit, 7 Ventiri str, 11528, Athens, Greece
    Reprod Biomed Online 15:408-12. 2007
    ....
  6. doi The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives
    Peter Humaidan
    The Fertility Clinic, Odense University Hospital, Odense, Denmark
    Reprod Biomed Online 24:134-41. 2012
    ..of final oocyte maturation is the use of GnRH agonist (GnRHa) which reduces or even prevents ovarian hyperstimulation syndrome (OHSS)...
  7. doi IVF outcome in women with PCOS, PCO and normal ovarian morphology
    Alexander Swanton
    Royal Berkshire Hospital, Reading, RG1 5AN, UK
    Eur J Obstet Gynecol Reprod Biol 149:68-71. 2010
    ..To examine the outcome of IVF in women who have normal ovaries, ovulatory PCO or PCOS...
  8. ncbi Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study
    Jiann Loung Hwang
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hum Reprod 19:1993-2000. 2004
    ..We proposed a stimulation protocol incorporating Diane-35 and GnRH antagonist (Diane/cetrorelix protocol) and compared it with the GnRH agonist long protocol for PCOS patients...
  9. doi Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis
    Mohamed A F M Youssef
    Department of Obstetrics and Gynaecology, Cairo University, Cairo, Egypt
    Hum Reprod Update 16:459-66. 2010
    Recently, dopamine agonists were proposed as a prophylactic treatment for ovarian hyperstimulation syndrome (OHSS) in women at high risk in IVF/ICSI treatment cycles.
  10. doi Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination
    Hang Wun Raymond Li
    Centre of Assisted Reproduction and Embryology, Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Fertil Steril 94:2177-81. 2010
    ..To evaluate the role of serum antimullerian hormone (AMH) concentration in predicting live birth outcome in controlled ovarian stimulation and intrauterine insemination (IUI)...
  11. ncbi Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade
    Raul Gomez
    Fundación IVI para el Estudio de la Reproducción, Valencia, Spain
    Endocrinology 143:4339-48. 2002
    ..molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human ..
  12. doi GnRH agonist for triggering of final oocyte maturation: time for a change of practice?
    P Humaidan
    The Fertility Clinic, Skive Regional Hospital, Resenvej 25, Skive, Denmark
    Hum Reprod Update 17:510-24. 2011
    GnRH agonist (GnRHa) triggering has been shown to significantly reduce the occurrence of ovarian hyperstimulation syndrome (OHSS) compared with hCG triggering; however, initially a poor reproductive outcome was reported after GnRHa ..
  13. ncbi Gonadotrophin-releasing hormone antagonists: will they replace the agonists?
    Ricardo E Felberbaum
    Department of Obstetrics and Gynaecology, Medical University of Lubeck, Ratzeburger Allee 160, 23 538 Lübeck, Germany
    Reprod Biomed Online 6:43-53. 2003
    ..Introducing flexible GnRH antagonist regimens should be the area of research in the near future...
  14. ncbi Physiology and pathology of ovarian hyperstimulation syndrome
    Raul Gomez
    Instituto Universitario IVI, Universidad de Valencia, Valencia, Spain
    Semin Reprod Med 28:448-57. 2010
    b>Ovarian hyperstimulation syndrome (OHSS) occurs when ovaries primed with follicle-stimulating hormone/leuteinizing hormone (LH) are subsequently exposed to human chorionic gonadotropin (hCG)...
  15. ncbi Low-dose HCG may improve pregnancy rates and lower OHSS in antagonist cycles: a meta-analysis
    I P Kosmas
    Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Ioannina University School of Medicine, Ioannina, Greece
    Reprod Biomed Online 19:619-30. 2009
    ..This may be useful in the prevention of ovarian hyperstimulation syndrome. Relevant studies were identified on Medline...
  16. ncbi Prevention of severe ovarian hyperstimulation syndrome in IVF with or without ICSI and embryo transfer: a modified 'coasting' strategy based on ultrasound for identification of high-risk patients
    T Al-Shawaf
    Fertility Centre, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, UK
    Hum Reprod 16:24-30. 2001
    b>Ovarian hyperstimulation syndrome (OHSS) can be a severe and potentially life-threatening complication of ovarian stimulation for IVF...
  17. doi A comparative study on the outcomes of in vitro fertilization between women with polycystic ovary syndrome and those with sonographic polycystic ovary-only in GnRH antagonist cycles
    Yong Jin Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yonkeun Dong, Chongno Gu, Seoul 110 744, South Korea
    Arch Gynecol Obstet 282:199-205. 2010
    ..This study was performed to compare the outcomes of controlled ovarian stimulation (COH) and IVF between women with PCOS and those with sonographic PCO-only in GnRH antagonist cycles...
  18. ncbi Identification of the high-risk patient for ovarian hyperstimulation syndrome
    Evangelos G Papanikolaou
    Assisted Reproduction Unit, 1st OB GYN Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Semin Reprod Med 28:458-62. 2010
    b>Ovarian hyperstimulation syndrome (OHSS), an iatrogenic complication of ovarian stimulation for assisted reproduction, is a potentially life-threatening condition...
  19. ncbi Management of severe OHSS using GnRH antagonist and blastocyst cryopreservation in PCOS patients treated with long protocol
    T G Lainas
    Eugonia Iatriki Erevna IVF Unit, Athens, Greece
    Reprod Biomed Online 18:15-20. 2009
    Despite the fact that many methods have been proposed for the management of severe ovarian hyperstimulation syndrome (OHSS), its prevention is mainly achieved by withholding human chorionic gonadotrophin (HCG) administration and cycle ..
  20. ncbi Comparison of GnRH agonists and antagonists in assisted reproduction cycles of patients at high risk of ovarian hyperstimulation syndrome
    G Ragni
    Infertility Unit, Department of Obstetrics Gynaecology, University of Milan, Italy
    Hum Reprod 20:2421-5. 2005
    During IVF or ICSI cycles, ovarian hyperstimulation syndrome (OHSS) is a major problem...
  21. ncbi Symposium: Update on prediction and management of OHSS. A modern classification of OHSS
    Abraham Golan
    IVF Unit, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon 58100, Israel
    Reprod Biomed Online 19:28-32. 2009
    b>Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of ovarian stimulation using fertility medications...
  22. ncbi Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome
    Sergio Reis Soares
    Instituto Valenciano de Infertilidad, IVI Lisboa Av Infante Dom Henrique, 333 H, 1800 282 Lisbon, Portugal
    Hum Reprod Update 14:321-33. 2008
    b>Ovarian hyperstimulation syndrome (OHSS) typically occurs when ovaries are primed with FSH/LH and subsequently exposed to hCG. The ultimate pathophysiological step underlying this clinical picture is increased vascular permeability (VP).
  23. ncbi Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment
    Raul Gomez
    Fundacion IVI, Institituto Universitario IVI Fundación Investigación Clinico de Valencia INCLIVA, 46015 Valencia, Spain
    J Clin Endocrinol Metab 96:2484-92. 2011
    ..Deregulation of the VEGF/VEGF receptor (VEGFR)-2 pathway leading to increased risk of ovarian hyperstimulation syndrome has been described in the ovary of patients suffering from polycystic ovarian syndrome (PCOS).
  24. ncbi Coasting-what is the best formula?
    O Levinsohn-Tavor
    IVF and Infertility Unit, Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Reprod 18:937-40. 2003
    Coasting is a method to decrease the incidence of ovarian hyperstimulation syndrome (OHSS), which involves withdrawing exogenous gonadotrophins until the serum estradiol (E(2)) level decreases...
  25. doi Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways
    Shee Uan Chen
    Department of Obstetrics and Gynecology, National Taiwan University, No 7 Chung Shan South Road, Taipei, Taiwan
    Hum Reprod 25:757-67. 2010
    b>Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovarian stimulation with massive ascites, pleural effusion and hemoconcentration...
  26. ncbi Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review
    A D'Angelo
    Department of Obstetrics and Gynaecology, University Hospital of Wales College of Medicine, Cardiff CF14 4XN, UK
    Hum Reprod 17:2787-94. 2002
    ..Cochrane reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and The Cochrane Library should be consulted for the most recent version of the review...
  27. doi Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability
    M Rodewald
    Department of Obstetrics and Gynecology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Hum Reprod 24:1191-9. 2009
    b>Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication of ovarian stimulation associated with severe vascular hyperpermeability...
  28. ncbi A qualitative systematic review of coasting, a procedure to avoid ovarian hyperstimulation syndrome in IVF patients
    Annick Delvigne
    IVF Centre, Department of Obstetrics Gynaecology, Free University of Brussels ULB, University Hospital St Pierre, Belgium
    Hum Reprod Update 8:291-6. 2002
    ..administration until the patient's serum estradiol (E2) level decreases, is often used to prevent ovarian hyperstimulation syndrome (OHSS)...
  29. ncbi Coasting acts through downregulation of VEGF gene expression and protein secretion
    J A Garcia-Velasco
    IVI Madrid, Rey Juan Carlos University, Spain
    Hum Reprod 19:1530-8. 2004
    This study was conducted to investigate the mechanisms by which coasting may be effective in decreasing the incidence of ovarian hyperstimulation syndrome (OHSS).
  30. ncbi Use of antagonists in ovarian stimulation protocols
    Luca Dal Prato
    Tecnobios Procreazione, Centre for Reproductive Health, Via Dante 15, I 40125 Bologna, Italy
    Reprod Biomed Online 10:330-8. 2005
    ..Pregnancy rate seems to be lower, but a decrease in the incidence of severe ovarian hyperstimulation syndrome (OHSS) is reported by several studies...
  31. ncbi Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS)
    Annick Delvigne
    IVF Centre, Department of Obstetrics Gynaecology, University Hospital St Pierre Free University of Brussels ULB, Brussels, Belgium
    Hum Reprod Update 9:77-96. 2003
    The ovarian hyperstimulation syndrome (OHSS) is a rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy...
  32. pmc The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial
    Cristiano Busso
    IVI Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 25:995-1004. 2010
    b>Ovarian hyperstimulation syndrome (OHSS) seems to be induced by the ovarian release of vascular endothelial growth factor (VEGF), which increases vascular permeability...
  33. ncbi Ovarian hyperstimulation syndrome: steps to maximize success and minimize effect for assisted reproductive outcome
    Puja S Gera
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 94:173-8. 2010
    To investigate the strategies used to decrease the risk of ovarian hyperstimulation syndrome (OHSS) and their impact on pregnancy and live birth rates.
  34. pmc Ovarian hyperstimulation syndrome: pathophysiology and prevention
    Carolina O Nastri
    Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo DGO HC FMRP USP, Avenida dos Bandeirantes 3900, 8 masculine Andar, Ribeirao Preto, Sao Paulo, Brazil, CEP 14049 900
    J Assist Reprod Genet 27:121-8. 2010
    To review and discuss the pathophysiology and prevention strategies for ovarian hyperstimulation syndrome (OHSS), which is a condition that may occur in up to 20% of the high risk women submitted to assisted reproductive technology cycles.
  35. doi Ovarian hyperstimulation syndrome and complications of ART
    Veerle Vloeberghs
    Leuven University Fertility Center, Department Obstetrics and Gynecology, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 23:691-709. 2009
    ..reproductive technology (ART) procedures (ovarian stimulation and oocyte aspiration), including ovarian hyperstimulation syndrome (OHSS), bleeding and infection...
  36. ncbi Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries
    R Agrawal
    University College London Medical School, Department of Reproductive Endocrinology, The Middlesex Hospital, London Women s Clinic, United Kingdom
    Fertil Steril 70:651-8. 1998
    ..to Doppler blood flow velocities within ovarian and uterine blood vessels during IVF cycles and to assess their relation to ovarian hyperstimulation syndrome (OHSS) and polycystic ovaries (PCO)/polycystic ovary syndrome (PCOS).
  37. pmc New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?
    A Delbaere
    Clinique de Fertilité, Hopital Erasme, Brussels, Belgium
    Hum Reprod 19:486-9. 2004
    ..which display an increased sensitivity to hCG and are responsible for the development of spontaneous ovarian hyperstimulation syndrome (OHSS), provides for the first time the molecular basis for the physiopathology of spontaneous OHSS...
  38. doi Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study
    Daniel Bodri
    Clinica Eugin, Barcelona, Spain
    Fertil Steril 91:365-71. 2009
    To compare pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in donor stimulation cycles where final maturation of oocytes was induced with recombinant hCG or GnRH agonist.
  39. ncbi New insights in mechanisms for development of ovarian hyperstimulation syndrome
    Miro Kasum
    Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Zagreb, Croatia
    Coll Antropol 34:1139-43. 2010
    The ovarian hyperstimulation syndrome (OHSS) is typically an iatrogenic complication of induction ovulation occurring during the luteal phase or early pregnancy...
  40. ncbi Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model
    Ramiro Quintana
    Instituto de Ginecología y fertilidad IFER, Buenos Aires, Argentina
    Fertil Steril 90:1511-6. 2008
    To investigate the effects of selective cyclooxygenase-2 (COX-2) inhibition on the ovarian hyperstimulation syndrome (OHSS) in an experimental model.
  41. ncbi Criteria of a successful coasting protocol for the prevention of severe ovarian hyperstimulation syndrome
    Ragaa Mansour
    The Egyptian IVF ET Center, 3, Road 161 Hadayek El Maadi, Cairo 11431, Egypt
    Hum Reprod 20:3167-72. 2005
    The aim of this study is to report a large series of patients (n = 1223) at risk of developing ovarian hyperstimulation syndrome (OHSS) who underwent coasting.
  42. ncbi Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study
    F Olivennes
    Reprod Biomed Online 18:195-204. 2009
    ..GONAL-f) dose was assigned by the algorithm and was intended to be altered only for risk of ovarian hyperstimulation syndrome (OHSS). Primary end-point was number of oocytes retrieved...
  43. doi Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment
    Paul Devroey
    Center for Reproductive Medicine, Dutch Speaking Brussels Free University, Laarbeeklaan 101, Brussels 1090, Belgium
    Hum Reprod 24:764-74. 2009
    ..To facilitate the implementation of treatments that optimize the patient's experience, a simple GnRH antagonist protocol for use in predicted normal responders is proposed...
  44. ncbi Cabergoline: a safe, easy, cheap, and effective drug for prevention/treatment of ovarian hyperstimulation syndrome?
    M Manno
    Eur J Obstet Gynecol Reprod Biol 122:127-8. 2005
  45. ncbi Intravenous albumin for preventing severe ovarian hyperstimulation syndrome: a Cochrane review
    M Aboulghar
    The Egyptian IVF ET Center, Maadi, Cairo and Cairo University, Department of Obstetrics and Gynecology
    Hum Reprod 17:3027-32. 2002
    The effectiveness of human albumin administration in prevention of severe ovarian hyperstimulation syndrome (OHSS) was reviewed using the Cochrane Menstrual Disorders and Subfertility Group literature search strategy.
  46. ncbi Symposium: Update on prediction and management of OHSS. Prevention of OHSS
    Mohamed Aboulghar
    Cairo University and the Egyptian IVF Center, Maadi, Cairo, Egypt
    Reprod Biomed Online 19:33-42. 2009
    b>Ovarian hyperstimulation syndrome (OHSS) is a major complication of ovulation induction. As the treatment of the syndrome is currently empirical, prevention is the most important aspect of its management...
  47. doi Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome
    Shee Uan Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
    J Clin Endocrinol Metab 93:935-43. 2008
    ..Angiogenic cytokines, including IL-6, IL-8, and vascular endothelial growth factor, increased in plasma and ascites of patients with ovarian hyperstimulation syndrome. The role of LPA in ovarian follicles is unclear.
  48. ncbi The optimal length of 'coasting protocol' in women at risk of ovarian hyperstimulation syndrome undergoing in vitro fertilization
    Luciano G Nardo
    Department of Reproductive Medicine, Saint Mary s Hospital, Whitworth Park, Manchester, UK
    Hum Fertil (Camb) 9:175-80. 2006
    b>Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially life-threatening complication following ovarian stimulation for in vitro fertilization (IVF)...
  49. ncbi A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome
    Claudine Vasseur
    Service de Gynecologie Obstetrique, Centre Hospitalier Universitaire d Angers, Angers, France
    N Engl J Med 349:753-9. 2003
  50. ncbi Treatment with gonadotropin-releasing hormone (GnRH) antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian hyperstimulation syndrome
    Robert L Gustofson
    Walter Reed Army Medical Center, National Naval Medical Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Fertil Steril 85:251-4. 2006
    Forty-seven patients at high risk for ovarian hyperstimulation syndrome because of markedly elevated serum E2 levels on either long-luteal or microdose flare leuprolide acetate regimens were treated with ganirelix acetate...
  51. ncbi Administration of intravenous albumin around the time of oocyte retrieval reduces pregnancy rate without preventing ovarian hyperstimulation syndrome: a systematic review and meta-analysis
    Byung Chul Jee
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang Seongnam, Gyeonggi, Korea
    Gynecol Obstet Invest 70:47-54. 2010
    The aim of this meta-analysis was to evaluate whether IV albumin infusion around the time of oocyte retrieval prevents ovarian hyperstimulation syndrome (OHSS) and affects the pregnancy rate.
  52. pmc Are pregnancy rates compromised following embryo freezing to prevent OHSS?
    Gerard J Fitzmaurice
    Daisy Hill Hospital, 5 Hospital Road, Newry, BT35 8DR, N Ireland
    Ulster Med J 77:164-7. 2008
    To compare pregnancy rates with fresh and frozen embryo transfer in patients admitted to Royal Jubilee Maternity Service (RJMS), Belfast between January 1st 2004 and December 31st 2005 with ovarian hyperstimulation syndrome (OHSS).
  53. ncbi Metabolic characteristics of women who developed ovarian hyperstimulation syndrome
    Annick Delvigne
    Departments of Obstetrics and Gynaecology, IVF and Haematology, St Pierre University Hospital, Free University of Brussels, rue Haute, 322, 1000 Brussels, Belgium
    Hum Reprod 17:1994-6. 2002
    ..investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients...
  54. pmc Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization
    Stephen R Lincoln
    Genetics and IVF Institute, Fairfax, Virginia 22031, USA
    J Assist Reprod Genet 19:159-63. 2002
    To assess the effectiveness of outpatient treatment of Ovarian Hyperstimulation Syndrome associated with ascites.
  55. ncbi Intravenous albumin versus hydroxyethyl starch for the prevention of ovarian hyperstimulation in an in-vitro fertilization programme: a prospective randomized placebo controlled study
    O Gokmen
    Department of Assisted Reproduction, Zekai Tahir Burak Education and Research Hospital, Tunali Hilmi cad. 64/2, Kavaklidere, 06660 Ankara, Turkey
    Eur J Obstet Gynecol Reprod Biol 96:187-92. 2001
    ..Both HES and albumin significantly reduced the incidence of moderate, severe and overall incidence of OHSS. It is concluded that hydroxyethyl starch is a cheaper and safer alternative to Human Albumin in OHSS prevention...
  56. ncbi Withholding gonadotropins until human chorionic gonadotropin administration
    Rony Abdallah
    The Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Semin Reprod Med 28:486-92. 2010
    ..or suspending gonadotropin administration, can be an effective strategy for decreasing the risk of ovarian hyperstimulation syndrome (OHSS) while reducing cancelation rates...
  57. doi Programming in vitro fertilization retrievals during working days after a gonadotropin-releasing hormone antagonist protocol with estrogen pretreatment: does the length of exposure to estradiol impact on controlled ovarian hyperstimulation outcomes?
    Anne Guivarc'h-Levêque
    Clinique Mutualiste La Sagesse, Rennes, France
    Fertil Steril 96:872-6. 2011
    ..To verify whether a variable number of days beyond the menses of estrogen (E) pretreatment may impact on controlled ovarian hyperstimulation (COH) outcomes and birth rate using a GnRH antagonist protocol...
  58. ncbi Vascular endothelial cadherin regulates vascular permeability: Implications for ovarian hyperstimulation syndrome
    A Villasante
    Instituto Valenciano de Infertilidad Madrid, C Santiago de Compostela, 88 bajo, 28035 Madrid, Spain
    J Clin Endocrinol Metab 92:314-21. 2007
    b>Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of treatment with fertility drugs...
  59. ncbi Use of intramuscular progesterone versus intravenous albumin for the prevention of ovarian hyperstimulation syndrome
    L Costabile
    Center for Reproductive Medicine and Infertility Therapy, Rome, Italy
    Gynecol Obstet Invest 50:182-5. 2000
    ..effectiveness of intramuscular progesterone with that of intravenous albumin in the prevention of ovarian hyperstimulation syndrome (OHSS)...
  60. ncbi Dual trigger of oocyte maturation with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin to optimize live birth rates in high responders
    Daniel Griffin
    Center for Advanced Reproductive Services, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 97:1316-20. 2012
    To compare live birth rates after dual trigger of oocyte maturation with GnRH agonist (GnRHa) and low-dose hCG versus GnRHa alone in high responders with peak E(2) <4,000 pg/mL at risk of ovarian hyperstimulation syndrome (OHSS).
  61. doi Ovarian hyperstimulation syndrome: a potentially fatal complication of early pregnancy
    Justin J Madill
    Madigan Army Medical Center Emergency Department, Tacoma, Washington, USA
    J Emerg Med 35:283-6. 2008
    ..This presentation is typical of Ovarian Hyperstimulation Syndrome (OHSS), a diagnosis that may be unfamiliar to many Emergency Physicians...
  62. ncbi Does elective cryopreservation of all embryos from women at risk of ovarian hyperstimulation syndrome reduce the incidence of the condition?
    I Wada
    Bourn Hall Clinic, Bourn, Cambridge, UK
    Br J Obstet Gynaecol 100:265-9. 1993
    To analyse the incidence and factors associated with the ovarian hyperstimulation syndrome (OHS) in our IVF/GIFT programme before and after the introduction of a strategy to cryopreserve all embryos from women judged to be at risk.
  63. ncbi GnRH antagonist in in vitro fertilization: where we are now
    D B Shapiro
    Reproductive Endocrinology Infertility, Reproductive Biology Associates, Atlanta, GA 30342, USA
    Minerva Ginecol 55:373-88. 2003
    ..As clinicians gain experience with these drugs, optimal treatment paradigms will likely emerge. This review will discuss current strategies and potential applications for the GnRH antagonists...
  64. ncbi An ounce of prevention: outpatient management of the ovarian hyperstimulation syndrome
    M R Fluker
    Genesis Fertility Centre, Vancouver, British Columbia, Canada
    Fertil Steril 73:821-4. 2000
    ..including outpatient paracentesis and albumin administration, in women at risk for severe ovarian hyperstimulation syndrome (OHSS). DESIGN: Prospective cohort. SETTING: Freestanding IVF program...
  65. ncbi Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting
    Andrea J DiLuigi
    The Center for Advanced Reproductive Services, Division of Reproductive Endocrinology and Infertility, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 94:1111-4. 2010
    ..There were no cases of ovarian hyperstimulation syndrome in either group, and the LA trigger group had significantly more oocytes retrieved (26.9+/-9.5 vs...
  66. ncbi Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma: incidental pregnancy triggers a catastrophic event
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Fertil Steril 92:390.e1-3. 2009
    To report a rare case of spontaneous ovarian hyperstimulation syndrome (OHSS) associated with spontaneous pregnancy and a FSH-secreting pituitary adenoma.
  67. pmc GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF/ET)
    Raffaella Depalo
    Unit of Physiopathology of Human Reproduction and Gametes Cryopreservation, Department of Gynecology, Obstetric and Neonatolgy, University of Bari Aldo Moro, Bari, Italy
    Reprod Biol Endocrinol 10:26. 2012
    ..Future developments have to be focused on timing of the administration of GnRH antagonists, by giving a great attention to new strategies of stimulation in patients in which radio-chemotherapy cycles are needed...
  68. ncbi Ovarian hyperstimulation syndrome in gonadotropin-treated laboratory South African clawed frogs (Xenopus laevis)
    Sherril L Green
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Am Assoc Lab Anim Sci 46:64-7. 2007
    b>Ovarian hyperstimulation syndrome (OHS) is a rare but sometimes fatal iatrogenic complication of ovarian stimulation associated with the administration of exogenous gonadotropins to women undergoing treatment for infertility...
  69. ncbi Ganirelix acetate causes a rapid reduction in estradiol levels without adversely affecting oocyte maturation in women pretreated with leuprolide acetate who are at risk of ovarian hyperstimulation syndrome
    Robert L Gustofson
    Reproductive Endocrinology and Infertility, NIH, Bethesda, MD, USA
    Hum Reprod 21:2830-7. 2006
    Elevated estradiol (E(2)) levels predispose to development of ovarian hyperstimulation syndrome (OHSS)...
  70. ncbi The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome
    A J Tozer
    Williamson Laboratory, St Bartholomew s and The London Hospitals Trust, London EC1A, UK
    Hum Reprod 19:522-8. 2004
    ..coasting) during controlled ovarian stimulation (COS) on individual follicle concentrations of follicular fluid vascular endothelial growth factor (VEGF) in women at high risk of developing ovarian hyperstimulation syndrome (OHSS).
  71. ncbi Ovarian hyperstimulation syndrome prevention strategies: cryopreservation of all embryos
    Arianna D'Angelo
    Cardiff University, University Hospital of Wales, Heath Park, Cardiff, United Kingdom
    Semin Reprod Med 28:513-8. 2010
    b>Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic potentially life-threatening condition resulting from excessive ovarian stimulation...
  72. ncbi Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program
    D Grochowski
    Department of Gynecology, IVF Unit, , , , Poland
    Gynecol Endocrinol 15:234-8. 2001
    ..method for the prevention of both cycle cancellation and complications associated with severe ovarian hyperstimulation syndrome (OHSS)...
  73. ncbi Does coasting, a procedure to avoid ovarian hyperstimulation syndrome, affect assisted reproduction cycle outcome?
    Nafiye Yilmaz
    Department of Infertility, Zekai Tahir Burak Women s Health Research and Education Hospital, Ankara, Turkey
    Fertil Steril 94:189-93. 2010
    ..To evaluate the effects of coasting (withdrawing gonadotropin administration) on IVF outcome...
  74. doi Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome
    Shee Uan Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    J Clin Endocrinol Metab 95:3982-92. 2010
    ..Its lifespan can be prolonged by human chorionic gonadotropin (hCG). However, the signal mechanisms of this phenomenon remain unclear...
  75. ncbi Spontaneous ovarian hyperstimulation syndrome in a normal singleton pregnancy
    Ozer Oztekin
    Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Taiwan J Obstet Gynecol 45:272-5. 2006
    It is known that most cases of ovarian hyperstimulation syndrome (OHSS) are associated with the therapies for ovulation induction...
  76. ncbi Reducing the dose of human chorionic gonadotropin in high responders does not affect the outcomes of in vitro fertilization
    David W Schmidt
    The Center for Advanced Reproductive Services, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 82:841-6. 2004
    ..The lowest effective hCG dose in high responders during IVF-embryo transfer (ET) has not been established. This study was performed to confirm that a dose of 3,300 IU is sufficient to provide adequate oocyte maturation and fertilization...
  77. ncbi Complications of assisted reproductive techniques
    J G Schenker
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
    Fertil Steril 61:411-22. 1994
    ..To review and appreciate the relevant data on assisted reproduction techniques and their potential complications...
  78. doi Update on management of ovarian hyperstimulation syndrome
    Chin Der Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    Taiwan J Obstet Gynecol 50:2-10. 2011
    b>Ovarian hyperstimulation syndrome (OHSS) is a relatively common complication of ovarian stimulation and can be life threatening...
  79. doi 1,500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study
    Peter Humaidan
    The Fertility Clinic, Skive Regional Hospital, Resenvej 25, 7800 Skive, Denmark
    Fertil Steril 93:847-54. 2010
    ..To prospectively assess the reproductive outcome with a small bolus of hCG administered on the day of oocyte retrieval after ovulation induction with a GnRH agonist (GnRHa)...
  80. ncbi Effect of paracentesis of ascitic fluids on urinary output and blood indices in patients with severe ovarian hyperstimulation syndrome
    Ishai Levin
    Department of Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Fertil Steril 77:986-8. 2002
    ..To determine the isolated effect of abdominal paracentesis of ascitic fluid in women with severe OHSS on urine production and blood indices...
  81. doi Cycles triggered with GnRH agonist: exploring low-dose HCG for luteal support
    J C Castillo
    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Hospital Clinico Universitario de Valencia, Blasco Ibañez Avenue 17, Valencia 46010, Spain
    Reprod Biomed Online 20:175-81. 2010
    The aim of this study in patients at risk of ovarian hyperstimulation syndrome (OHSS) was to determine the efficacy and safety of luteal support using human chorionic gonadotrophin (HCG) after triggering ovulation with gonadotrophin-..
  82. ncbi Ovarian hyperstimulation syndrome (OHSS): new strategies of prevention and treatment
    Shee Uan Chen
    J Formos Med Assoc 107:509-12. 2008
  83. ncbi Spontaneous ovarian hyperstimulation syndrome caused by hypothyroidism in an adult
    Bassam M Taher
    National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, P O Box 13165, Amman 11942, Jordan
    Eur J Obstet Gynecol Reprod Biol 112:107-9. 2004
    ..A 22-year-old patient presented with abdominal pain and massive ovarian enlargement secondary to severe long standing hypothyroidism, mimicking an ovarian cancer. Treatment with L-thyroxin caused marked regression of the tumor...
  84. ncbi Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome
    Guy Gutman
    Sara Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Reprod Immunol 51:381-4. 2004
    The presence of interleukin-18 (IL-18) in serum and pre-ovulatory follicular fluid (FF) and its possible correlation to in-vitro fertilization/embryo transfer (IVF/ET) outcome and ovarian hyperstimulation syndrome (OHSS) development.
  85. ncbi Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study
    Jose Bellver
    Department of Infertility, Instituto Valenciano de Infertilidad IVI, Plaza de la Policia Local 3, 46015, Valencia, Spain
    Hum Reprod 18:2283-8. 2003
    ..has been described for many years as a debatable, but probably useful preventive measure in ovarian hyperstimulation syndrome (OHSS)...
  86. ncbi Can we eliminate severe ovarian hyperstimulation syndrome?
    Raoul Orvieto
    Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva 49 100 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Reprod 20:320-2. 2005
    ..between optimum ovarian stimulation and successful treatment outcome with minimal rate of severe ovarian hyperstimulation syndrome (OHSS) or multiple pregnancies...
  87. ncbi Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome
    Helge Binder
    Department of Obstetrics and Gynaecology, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054 Erlangen, Germany
    Reproduction 135:107-16. 2008
    Severe ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication during assisted reproduction technology (ART). The aetiology of this condition is still not fully understood...
  88. ncbi Prediction of ovarian hyperstimulation syndrome: why predict if we can prevent!
    Shahar Kol
    Hum Reprod 18:1557-8. 2003
  89. ncbi A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome
    Lucia Montanelli
    IRIBHM, ULB, Brussels, Belgium
    J Clin Endocrinol Metab 89:1255-8. 2004
    b>Ovarian hyperstimulation syndrome (OHSS) occurs mainly after excessive stimulation of the ovaries by exogenous gonadotropins administrated in the context of in vitro fertilization procedures (iatrogenic OHSS)...
  90. doi Ovarian hyperstimulation syndrome following the sole administration of injectable gonadotropin-releasing hormone agonist (triptorelin) for the pituitary down-regulation and in vitro fertilization treatment: report of two cases
    Hussein S Qublan
    Department of Obstetrics and Gynecology, IVF Center, Prince Rashed Hospital, Royal Medical Services, Irbid Aidoun, Jordan
    Arch Gynecol Obstet 279:221-3. 2009
    This report is to illustrate two cases of ovarian hyperstimulation syndrome following the sole administration of injectable mid-luteal gonadotropin-releasing hormone agonists (triptorelin) for pituitary down-regulation...
  91. ncbi Symposium: Update on prediction and management of OHSS. Genetics of ovarian hyperstimulation syndrome
    Botros Rizk
    University of South Alabama College of Medicine, Department of Obstetrics and Gynecology, 251 Cox Street, Suite 100, Mobile, AL 36604, USA
    Reprod Biomed Online 19:14-27. 2009
    b>Ovarian hyperstimulation syndrome (OHSS) is typically iatrogenic following the administration of gonadotrophins...
  92. ncbi Ovarian hyperstimulation syndrome and assisted reproductive technologies: why some and not others?
    Bernie McElhinney
    School of Medicine, Obstetrics and Gynaecology, Queen s University Belfast, UK
    Hum Reprod 17:1548-53. 2002
    ..The aim of this study was to determine if there is a relationship between serum VEGF levels, alpha(2)M levels and the development of OHSS in hyperstimulated subjects undergoing IVF (those with 15 or more oocytes)...
  93. ncbi Combined approach as an effective method in the prevention of severe ovarian hyperstimulation syndrome
    A Z Isik
    Bayindir Medical Center, Assisted Reproductive Technologies Unit, Ankara, Turkey
    Eur J Obstet Gynecol Reprod Biol 97:208-12. 2001
    ..of this study was to evaluate the effectiveness of combined approach on the prevention of severe ovarian hyperstimulation syndrome (OHSS) in high risk patients undergoing controlled ovarian hyperstimulation for IVF...
  94. pmc Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series
    Marlena S Fejzo
    Department of Maternal Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Fertil Steril 93:267.e9-11. 2010
    ..To investigate the symptoms and outcomes of ovarian stimulation in patients with a history of hyperemesis gravidarum...
  95. pmc Ovarian hyperstimulation syndrome complicating a spontaneous singleton pregnancy: a case report
    H D Chae
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, 388-1, Poongnap-dong, Songpa-gu, Seoul, 138-736, Korea
    J Assist Reprod Genet 18:120-3. 2001
    It has been known that most cases of ovarian hyperstimulation syndrome (OHSS) are associated with the use of exogenous gonadotropins to induce multiple ovulation...
  96. doi Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome
    Akos Varnagy
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pecs, H 7624 Pecs, Hungary
    Fertil Steril 93:2281-4. 2010
    To evaluate the effect of low-dose aspirin therapy on ovarian hyperstimulation syndrome (OHSS) in an unselected group of patients undergoing in vitro fertilization (IVF).
  97. ncbi Ovarian hyperstimulation syndrome (OHSS) due to mutations in the follicle-stimulating hormone receptor
    P Rodien
    Centre de référence des maladies de la réceptivité hormonale, CHU d Angers, 4, rue Larrey, 49933 Angers Cedex 9, France
    Ann Endocrinol (Paris) 71:206-9. 2010
    b>Ovarian hyperstimulation syndrome (OHSS) is usually a complication of assisted reproductive techniques, more rarely an affection complicating a spontaneous gestation...
  98. ncbi The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1beta, interleukin-6, and vascular endothelial growth factor
    A Pellicer
    Instituto Valenciano de Infertilidad, Department of Pediatrics, Obstetrics and Gynecology, Valencia University School of Medicine, Spain
    Fertil Steril 71:482-9. 1999
    ..of the substance; to evaluate serum and follicular fluid levels of these cytokines as markers of ovarian hyperstimulation syndrome (OHSS), and to compare levels of these cytokines under basal conditions in women with normal ..
  99. ncbi Ovarian hyperstimulation syndrome associated with the use of the gonadotropin-releasing hormone agonist leuprolide acetate
    K Droesch
    Department of Obstetrics and Gynecology, State University of New York at Stony Brook 11794 8091
    Fertil Steril 62:189-90. 1994
    Severe ovarian hyperstimulation syndrome occurred after the administration of LA to suppress multicystic ovaries...
  100. ncbi Stroke in ovarian hyperstimulation syndrome in early pregnancy treated with intra-arterial rt-PA
    K Elford
    Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    Neurology 59:1270-2. 2002
    b>Ovarian hyperstimulation syndrome (OHSS) caused by fertility medications can predispose women to thrombosis...
  101. ncbi Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review
    Annick Delvigne
    IVF Centre, Department of Obstetrics Gynaecology, University Hospital St Pierre Free University of Brussels ULB, Belgium
    Hum Reprod Update 8:559-77. 2002
    b>Ovarian hyperstimulation syndrome (OHSS) is a rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy...

Research Grants62

  1. Infrastructure for Human Embryonic Stem Cells Productio*
    Joseph Itskovitz Eldor; Fiscal Year: 2005
    ..These improvements will constitute the ability to grow and propagate hESCs in large quantities in conditions that promote both research and clinical utilization of these cells. ..
  2. Rosiglitazone and Clomiphene for Ovulation Induction
    Nicholas Cataldo; Fiscal Year: 2002
    ..FSH, but this is associated with a greater risk than clomiphene of both multiple gestation and ovarian hyperstimulation syndrome, which in its severe form can be life- threatening...
  3. Rosiglitazone and Clomiphene for Ovulation Induction
    Nicholas Cataldo; Fiscal Year: 2001
    ..FSH, but this is associated with a greater risk than clomiphene of both multiple gestation and ovarian hyperstimulation syndrome, which in its severe form can be life- threatening...
  4. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..Serious complications of these therapies include multiple pregnancy, ovarian hyperstimulation syndrome (OHSS), and premature delivery (even in singletons)...
  5. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..These include, for example, PCOS, ovarian cancer, and ovarian hyperstimulation syndrome (OHSS)...
  6. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..These include, for example, PCOS, ovarian cancer, and ovarian hyperstimulation syndrome (OHSS)...
  7. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2002
    ..Serious complications of these therapies include multiple pregnancy, ovarian hyperstimulation syndrome (OHSS), and premature delivery (even in singletons)...
  8. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2003
    ..Serious complications of these therapies include multiple pregnancy, ovarian hyperstimulation syndrome (OHSS), and premature delivery (even in singletons)...
  9. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2001
    ..Serious complications of these therapies include multiple pregnancy, ovarian hyperstimulation syndrome (OHSS), and premature delivery (even in singletons)...
  10. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2000
    ..Serious complications of these therapies include multiple pregnancy, ovarian hyperstimulation syndrome (OHSS), and premature delivery (even in singletons)...
  11. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2001
    ..the unique pathophysiology of insulin resistance in PCOS places these women at particular risk for ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy with this form of therapy...
  12. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2003
    ..the unique pathophysiology of insulin resistance in PCOS places these women at particular risk for ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy with this form of therapy...
  13. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2002
    ..the unique pathophysiology of insulin resistance in PCOS places these women at particular risk for ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy with this form of therapy...
  14. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2004
    ..the unique pathophysiology of insulin resistance in PCOS places these women at particular risk for ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy with this form of therapy...
  15. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2000
    ..the unique pathophysiology of insulin resistance in PCOS places these women at particular risk for ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy with this form of therapy...
  16. Granulosa Cell Function in Polycystic Ovary Syndrome
    R Chang; Fiscal Year: 2004
    ..has particular important clinical relevance as excessive granulosa cell stimulation may lead to ovarian hyperstimulation syndrome and potential serious life-threatening complications...
  17. The Lymphatic System in the Primate corpus Luteum
    Fuhua Xu; Fiscal Year: 2007
    ..on the regulation and role of the lymphatic system in the primate ovary during the normal menstrual cycle and in ovarian disorders, such as ovarian hyperstimulation syndrome or ovarian cysts. [unreadable] [unreadable] [unreadable]
  18. Angiogenic and Angiolytic Factors in Natural and Controlled Ovarian Stimulation
    Richard Stouffer; Fiscal Year: 2004
    ..VEGF-A is associated with controlled ovarian stimulation (COS) cycles, and is an etiologic factor in ovarian hyperstimulation syndrome (OHSS)...
  19. Granulosa Cell Function in Polycystic Ovary Syndrome
    R Chang; Fiscal Year: 2005
    ..The latter consideration has important clinical relevance as excessive GC stimulation may lead to ovarian hyperstimulation syndrome and potential serious life-threatening complications...
  20. Genes regulated by activin receptor II signaling in gonadotropes
    T Kumar; Fiscal Year: 2009
    ..These include ovarian hyperstimulation syndrome, amenorrhea and testicular defects.
  21. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2005
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  22. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2006
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  23. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2004
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  24. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard L Stouffer; Fiscal Year: 2010
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  25. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2006
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  26. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2007
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  27. ADMINISTRATIVE CORE
    Richard Stouffer; Fiscal Year: 2009
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  28. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2009
    ..luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS)...
  29. Angiogenic & Angiolytic Factors in Natural & Controlled Ovarian Stimulation Cycle
    Richard Stouffer; Fiscal Year: 2009
    ..VEGF-A is associated with controlled ovarian stimulation (COS) cycles, and is an etiologic factor in ovarian hyperstimulation syndrome (OHSS)...
  30. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted.
  31. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2000
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted.
  32. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 1999
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted.
  33. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2002
    ..The fourth project, "Vasoactive Factors in ART Cycles and Ovarian Hyperstimulation Syndrome (OHSS), " will test the hypothesis that methods used to generate multiple mature follicles/corpora ..
  34. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 1999
    ..The fourth project, "Vasoactive Factors in ART Cycles and Ovarian Hyperstimulation Syndrome (OHSS), " will test the hypothesis that methods used to generate multiple mature follicles/corpora ..
  35. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2000
    ..The fourth project, "Vasoactive Factors in ART Cycles and Ovarian Hyperstimulation Syndrome (OHSS), " will test the hypothesis that methods used to generate multiple mature follicles/corpora ..
  36. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2001
    ..The fourth project, "Vasoactive Factors in ART Cycles and Ovarian Hyperstimulation Syndrome (OHSS), " will test the hypothesis that methods used to generate multiple mature follicles/corpora ..
  37. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard Stouffer; Fiscal Year: 2003
    ..The fourth project, "Vasoactive Factors in ART Cycles and Ovarian Hyperstimulation Syndrome (OHSS), " will test the hypothesis that methods used to generate multiple mature follicles/corpora ..
  38. VASOACTIVE FACTORS IN MENSTRUAL CYCLES & OVARIAN HYPERSTIMULATION SYNDROME
    Richard Stouffer; Fiscal Year: 2000
    ..Modulation of primate coronary artery reactivity by estrogens and progestins occurs over a period of weeks in culture. Both reactivity and receptors are being studied in this project. FUNDING Wyeth-Ayerst PUBLICATIONS None ..
  39. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2008
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  40. Short-term course in human embryonic stem cell culture techniques
    Joseph Itskovitz Eldor; Fiscal Year: 2008
    ..Thus, this guiding program will further encourage the distribution and research based on hESC. [unreadable] [unreadable] [unreadable]..
  41. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
    ..Project Description Page 6 ..
  42. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2009
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  43. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  44. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2001
    ....
  45. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  46. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2000
    ....
  47. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  48. Infrastructure for Human Embryonic Stem Cells Productio*
    Joseph Itskovitz Eldor; Fiscal Year: 2007
    ..These improvements will constitute the ability to grow and propagate hESCs in large quantities in conditions that promote both research and clinical utilization of these cells. ..
  49. BIOLOGICAL BASIS OF THE PERIMENOPAUSE
    DAVID SEIFER; Fiscal Year: 2002
    ....
  50. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  51. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2004
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  52. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2003
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  53. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2005
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  54. Angiogenesis Induction by Vasculogenic Progenitor Cells
    Joseph Itskovitz Eldor; Fiscal Year: 2005
    ..We expect that this research will establish the foundation for an effective therapeutic modality using hES cells for some of the most leading causes of morbidity and mortality in the world. ..
  55. Angiogenesis Induction by Vasculogenic Progenitor Cells
    Joseph Itskovitz Eldor; Fiscal Year: 2003
    ..We expect that this research will establish the foundation for an effective therapeutic modality using hES cells for some of the most leading causes of morbidity and mortality in the world. ..
  56. Infrastructure for Stem Cell Production & Distribution
    Joseph Itskovitz Eldor; Fiscal Year: 2004
    ..This will significantly increase the potential of research applications of human ES cells and the rate of discoveries of potential human ES cell-derived therapies for treating some of the most common and devastating human diseases. ..
  57. Angiogenesis Induction by Vasculogenic Progenitor Cells
    Joseph Itskovitz Eldor; Fiscal Year: 2006
    ..We expect that this research will establish the foundation for an effective therapeutic modality using hES cells for some of the most leading causes of morbidity and mortality in the world. ..
  58. Infrastructure for Human Embryonic Stem Cells Productio*
    Joseph Itskovitz Eldor; Fiscal Year: 2006
    ..abstract_text> ..
  59. Infrastructure for Stem Cell Production & Distribution
    Joseph Itskovitz Eldor; Fiscal Year: 2002
    ..This will significantly increase the potential of research applications of human ES cells and the rate of discoveries of potential human ES cell-derived therapies for treating some of the most common and devastating human diseases. ..
  60. Short-term course in human embryonic stem cell culture techniques
    Joseph Itskovitz Eldor; Fiscal Year: 2007
    ..Thus, this guiding program will further encourage the distribution and research based on hESC. [unreadable] [unreadable] [unreadable]..
  61. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2002
    ....
  62. Angiogenesis Induction by Vasculogenic Progenitor Cells
    Joseph Itskovitz Eldor; Fiscal Year: 2004
    ..We expect that this research will establish the foundation for an effective therapeutic modality using hES cells for some of the most leading causes of morbidity and mortality in the world. ..