leydig cell tumor

Summary

Summary: Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.

Top Publications

  1. ncbi Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs
    M A Peters
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Reproduction 121:287-96. 2001
  2. doi Gonadotropin-independent precocious puberty associated with a somatic activating mutation of the LH receptor gene: detection of a mutation present in only a small fraction of cells from testicular tissue using wild-type blocking polymerase chain reaction
    Katsumi Goji
    Department of Endocrinology and Metabolism, Kobe Children s Hospital, Suma ku, Kobe 654 0081, Japan
    Endocrine 35:397-401. 2009
  3. ncbi Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy
    Cancer Res 67:8368-77. 2007
  4. ncbi Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1)
    Yu Bang Wang
    Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing, People s Republic of China
    J Toxicol Environ Health A 70:947-55. 2007
  5. ncbi Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence
    Maki Fukami
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    J Biol Chem 283:5525-32. 2008
  6. doi Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-β hydroxylase deficiency: a case report
    Pegah Entezari
    Pediatric Urology Research Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, No 32, 2nd Floor, 7th Street, Saadat Abad, Ave, Tehran 1998714616, Iran
    Int Urol Nephrol 44:133-7. 2012
  7. ncbi Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature
    Antonio Santoriello
    Second University of Naples, School of Medicine, Unit of General and Geriatric Surgery, Naples, Italy
    Ann Ital Chir 81:445-8. 2010
  8. doi Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system
    Adele Chimento
    Department of Pharmaco Biology, University of Calabria, Cosenza, Italy
    J Cell Physiol 227:2079-88. 2012
  9. ncbi Development of true precocious puberty following treatment of a Leydig cell tumor of the testis
    A A Ghazi
    Department of Endocrinology, Taleghani Hospital, Beheshti University of Medical Sciences, Tehran, Iran
    J Pediatr Endocrinol Metab 14:1679-81. 2001
  10. ncbi Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity
    Sabrina Basciani
    Department of Medical Physiopathology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Cancer Res 65:1897-903. 2005

Research Grants

  1. HORMONAL REGULATION OF GAMETOGENESIS
    Marco Conti; Fiscal Year: 1993
  2. KCNRG gene as candidate tumor suppressor for CLL and MM
    Anna Baranova; Fiscal Year: 2005
  3. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
  4. PLATELET DERIVED GROWTH FACTOR IN FOLLICLE DEVELOPMENT
    Christopher Taylor; Fiscal Year: 2002
  5. COX2-Regulated Testosterone Biosynthesis in Male Aging
    XingJia Wang; Fiscal Year: 2009

Detail Information

Publications197 found, 100 shown here

  1. ncbi Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs
    M A Peters
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Reproduction 121:287-96. 2001
    ..Overall, this panel of antibodies can be very useful for determination of the identity of testicular tumours in which histological characterization is complicated and the pathogenesis of feminization is not clear...
  2. doi Gonadotropin-independent precocious puberty associated with a somatic activating mutation of the LH receptor gene: detection of a mutation present in only a small fraction of cells from testicular tissue using wild-type blocking polymerase chain reaction
    Katsumi Goji
    Department of Endocrinology and Metabolism, Kobe Children s Hospital, Suma ku, Kobe 654 0081, Japan
    Endocrine 35:397-401. 2009
    ..We report a molecular study of a boy with gonadotropin-independent precocious puberty caused by a Leydig cell tumor.
  3. ncbi Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy
    Cancer Res 67:8368-77. 2007
    The aim of this study was to investigate the role of estrogens in Leydig cell tumor proliferation. We used R2C rat Leydig tumor cells and testicular samples from Fischer rats with a developed Leydig tumor...
  4. ncbi Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1)
    Yu Bang Wang
    Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing, People s Republic of China
    J Toxicol Environ Health A 70:947-55. 2007
    ..Data indicate that MBP interfered with steroid hormone production by affecting StAR expression in MLTC-1 cells...
  5. ncbi Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence
    Maki Fukami
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    J Biol Chem 283:5525-32. 2008
    ..We designate CXorf6 as MAMLD1 (mastermind-like domain-containing 1) based on its characteristic structure...
  6. doi Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-β hydroxylase deficiency: a case report
    Pegah Entezari
    Pediatric Urology Research Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, No 32, 2nd Floor, 7th Street, Saadat Abad, Ave, Tehran 1998714616, Iran
    Int Urol Nephrol 44:133-7. 2012
    ..Two differential diagnoses were noticed for both patients: testicular adrenal rest tumors (TART) and Leydig cell tumor (LCT). In this study the tumors were yellow, firm, and non-tender with intra-testicular location...
  7. ncbi Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature
    Antonio Santoriello
    Second University of Naples, School of Medicine, Unit of General and Geriatric Surgery, Naples, Italy
    Ann Ital Chir 81:445-8. 2010
    ..This report describes a case of a monorchid patient suffering from Adrenogenital Syndrome and Leydig cell tumor of his testis...
  8. doi Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system
    Adele Chimento
    Department of Pharmaco Biology, University of Calabria, Cosenza, Italy
    J Cell Physiol 227:2079-88. 2012
    ..study we aimed to determine if nandrolone and stanozolol, two commonly used AAS, could have an effect on Leydig cell tumor proliferation and if their effects could be potentiated by the concomitant use of IGF-I...
  9. ncbi Development of true precocious puberty following treatment of a Leydig cell tumor of the testis
    A A Ghazi
    Department of Endocrinology, Taleghani Hospital, Beheshti University of Medical Sciences, Tehran, Iran
    J Pediatr Endocrinol Metab 14:1679-81. 2001
    We report a prepubertal boy who developed true precocious puberty following unilateral orchidectomy for the treatment of a Leydig cell tumor.
  10. ncbi Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity
    Sabrina Basciani
    Department of Medical Physiopathology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Cancer Res 65:1897-903. 2005
    ..kinases, on the growth of rodent Leydig tumor cell lines in vivo and in vitro, and examined, in human Leydig cell tumor samples, the expression of activated PDGFR and c-kit and the mutations in exons of the c-kit gene commonly ..
  11. doi Lessons from 52 patients with leydig cell tumor of the testis: the GUONE (North-Eastern Uro-Oncological Group, Italy) experience
    Fulvio Di Tonno
    Division of Urology, Hospital of Mestre Venice, Italy
    Urol Int 82:152-7. 2009
    ..The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis...
  12. ncbi A malignant Leydig cell tumor of the testis
    Koichi Sugimoto
    Department of Urology, School of Medicine, Kinki University, 2 377 Ohnohigashi, 589 8511, Osakasayama, Osaka, Japan
    Int Urol Nephrol 38:291-2. 2006
    ..We performed right high orchiectomy. Histologically, Reinke's crystals and capsular invasion by tumor cells were found. Final diagnosis, the tumor was a malignant Leydig cell tumor of the testis.
  13. ncbi Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency
    Hidefumi Inaba
    Department of Aging and Geriatrics, Shinshu University, Matsumoto, Japan
    Intern Med 48:601-5. 2009
    ..Five years earlier, he underwent simultaneous surgeries for an adrenal adenoma, a benign Leydig cell tumor (LCT), and a malignant lymphoma...
  14. pmc Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells
    Jinjiang Fan
    The Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Room C10 148, Montreal, Quebec, Canada H3G 1A4
    Endocrinology 151:3348-62. 2010
    ..A model for the mechanism of MEHP action on MA-10 Leydig cell steroidogenesis is proposed...
  15. ncbi Mouse Leydig tumor cells produce C-19 steroids, including testosterone
    Nirmal S Panesar
    Department of Chemical Pathology, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administrative Region, Shatin, PR China
    Steroids 68:245-51. 2003
    The mouse Leydig tumor cells (MLTC-1) were derived from a transplantable Leydig cell tumor carried in C57BL/6 mice. The original cell line (M5480) produced testosterone and little progesterone...
  16. doi Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome
    L V Monteagudo
    Laboratory of Cytogenetics and Molecular Genetics, University of Zaragoza, Faculty of Veterinary Science, Zaragoza, Spain
    Vet Pathol 45:42-5. 2008
    ..An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed...
  17. ncbi Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases
    Luca Carmignani
    Urology Unit, Department of Medicine and Surgery, University of Milan, Italy
    J Urol 176:2040-3; discussion 2043. 2006
    ..We performed a retrospective multicenter evaluation of clinical and histological characteristics as well as followup of Leydig cell tumors...
  18. doi Leydig cell tumor: an unusual presentation
    Usha Agrawal
    Institute of Pathology, ICMR, Safdarjang Hospital Campus, New Delhi, India
    Indian J Pathol Microbiol 52:395-6. 2009
    b>Leydig cell tumor is a benign tumor of the testis and malignant transformation, if present, is rare. The case presented here showed certain features of malignancy but no infiltration beyond the capsule or metastasis...
  19. ncbi [Leydig cell tumor: report of 8 cases and review of the literature]
    G Cruceyra Betriu
    Servicio de Urologia, Hospital Universitario 12 de Octubre, Madrid
    Actas Urol Esp 26:36-40. 2002
    b>Leydig cell tumor is the most frequent non-germ cell tumors of testis, included in the group of specialized gonadal stromal neoplasms. It has a low incidence, accounting for 1-3% of testicular neoplasms...
  20. ncbi Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor
    Amalia Carpino
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
    Eur J Endocrinol 157:239-44. 2007
    A Leydig cell tumor is a rare neoplasm, deriving from the interstitial cells, whose pathogenesis has not been still defined. Leydig cells of normal adult testis are known as physiological targets for estrogens...
  21. ncbi Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog
    M A Owston
    Animal Disease Diagnostic Laboratory and Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, 406 South University, West Lafayette, IN 47907 2065, USA
    Vet Pathol 44:936-43. 2007
    ..We describe the histopathology and immunohistochemical characteristics of an MGSCT associated with a Leydig cell tumor in a cryptorchid testis...
  22. ncbi Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome
    Ichiro Iwamoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Gynecol Oncol 96:870-2. 2005
    ..Testicular tumors often develop in patients with AIS, Sertoli cell tumor and seminoma being the most common types. Leydig cell tumor in AIS is extremely rare.
  23. ncbi Enucleation for prepubertal leydig cell tumor
    C Gerry Henderson
    Division of Pediatric Urology, Children s National Medical Center, Washington, DC, USA
    J Urol 176:703-5. 2006
    ..We present our experience with testis sparing enucleation of Leydig cell tumor in prepubertal boys.
  24. ncbi A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy
    C P Carron
    Department of Discovery Pharmacology, Searle Research and Development, Monsanto Company, St Louis, Missouri 63198, USA
    Cancer Res 58:1930-5. 1998
    ..A xenogeneic severe combined immune deficiency mouse/rat Leydig cell tumor model was developed for testing SC-68448 as an inhibitor of tumor growth in vivo...
  25. ncbi An in-depth look at Leydig cell tumor of the testis
    Osama M Al-Agha
    Department of Pathology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Box 25, Brooklyn, NY 11203, USA
    Arch Pathol Lab Med 131:311-7. 2007
    b>Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium...
  26. ncbi Conservative surgical therapy for leydig cell tumor
    Luca Carmignani
    Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Urol 178:507-11; discussion 511. 2007
    We performed a long-term evaluation of conservative surgical treatment of benign Leydig cell tumor.
  27. ncbi [Testicular tumors--a current review]
    S Buse
    Klinik für Urologie, Kantonsspital St Gallen
    Praxis (Bern 1994) 92:1989-97. 2003
    ..The following treatment depends on the staging: wait and see, radiotherapy or chemotherapy. Testicular cancer is characterised by a good cure rate (98-100% early stages) or recurrence free survival (80-90% late stages)...
  28. pmc Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
    XingJia Wang
    Garrison Institute on Aging, Department of Neuropsychiatry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Endocrinology 149:851-7. 2008
    ....
  29. ncbi PPARalpha agonist-induced rodent tumors: modes of action and human relevance
    James E Klaunig
    Indiana University School of Medicine, Indianapolis, IN, USA
    Crit Rev Toxicol 33:655-780. 2003
    ....
  30. ncbi Gonadotropin-mediated regulation of the murine VEGF expression in MA-10 Leydig cells
    Heidi Schwarzenbach
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, D 22529 Hamburg, Germany
    J Androl 25:128-39. 2004
    ..Progesterone also appears to play a role in the regulation of VEGF, acting presumably via a nonconventional receptor that remains to be characterized yet...
  31. ncbi The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Cell Endocrinol 119:135-46. 1996
    ..This gonadal tumor model is valuable for further studies on endocrine functions of Leydig cells and their tumorigenesis in vivo and in vitro...
  32. doi Canine testicular tumours: a study on 232 dogs
    V Grieco
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Milano, Italy
    J Comp Pathol 138:86-9. 2008
    ..The results suggest that, as reported in man, testicular tumours in dogs have increased during the past 40 years. Further studies should investigate the possible causative role of environmental pollutants...
  33. pmc Expression of the insulin-like growth factor (IGF) system and steroidogenic enzymes in canine testis tumors
    Monique A J Peters
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Universiteit Utrecht, The Netherlands
    Reprod Biol Endocrinol 1:22. 2003
    ..It was concluded that Sertoli cell tumors and seminomas have a comparable expression of the IGF system while Leydig cell tumors have a different pattern, suggesting difference in pathobiology among these types of tumors...
  34. ncbi A novel approach of targeted ablation of mammary carcinoma cells through luteinizing hormone receptors using Hecate-CGbeta conjugate
    Gabriel Bodek
    Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    Breast Cancer Res Treat 79:1-10. 2003
    ..At a concentration of 33 microM the conjugate inhibited (50%; IC50) the binding of CG to LHR. We suggest further development of this novel approach for the treatment of breast cancer by the Hecate-CGbeta for in vivo trials...
  35. ncbi Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes
    Frank Mayer
    Pathology Laboratory for Experimental Patho Oncology, Josephine Nefkens Institute, Erasmus Medical Center Daniel den Hoed Cancer Center, 3000 DR Rotterdam, The Netherlands
    Oncogene 22:3859-66. 2003
    ..Therefore, aneuploidy of testicular germ cell tumors is associated with amplified centrosomes probably unrelated to STK15...
  36. ncbi A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia
    Takashi Hirakawa
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 144:3872-8. 2003
    ..The data presented here suggest that such mechanisms do not need to be considered...
  37. ncbi Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors
    F Gaytan
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, 14004 Cordoba, Spain
    J Clin Endocrinol Metab 89:400-9. 2004
    ..Ghrelin immunoreactivity was absent in poorly differentiated Leydig cell tumor, which retained the expression of GHS-R1a peptide...
  38. ncbi High incidence of benign testicular neoplasms diagnosed by ultrasound
    Luca Carmignani
    Urology Unit, Department of Medicine, Surgery and Dental Sciences, University of Milan, San Paolo Hospital, Via Antonio Di Rudini 8, Milan, Italy 20142
    J Urol 170:1783-6. 2003
    ....
  39. ncbi Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells
    B M Huang
    Department of Cell Biology and Anatomy, National Cheng Kung University, Medical College, Tainan 704, Taiwan
    Arch Androl 50:5-9. 2004
    ....
  40. ncbi Leydig cell tumor and hyperplasia: a review
    Maurizio Colecchia
    Department of Pathology, National Cancer Institute Foundation, Milan, Italy
    Anal Quant Cytol Histol 29:139-47. 2007
    ..Recent acquisitions on etiology and pathobiology of Leydig cell proliferations, unusual microscopic presentations and clinical and morphologic features predictive of malignancy are reported...
  41. ncbi OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 28:935-40. 2004
    ..OCT4 immunostaining has comparable sensitivity but greater consistency compared with CD30 in the diagnosis of embryonal carcinoma...
  42. pmc Extratesticular interstitial and Sertoli cell tumors in previously neutered dogs and cats: a report of 17 cases
    Angela L Doxsee
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario
    Can Vet J 47:763-6. 2006
    ..Several possibilities, including the presence of embryological ectopic tissue or the presence of testicular tissue transplanted during castration, are considered as causal...
  43. ncbi [Testicular neoplasms (germ cell tumors, Leydig cell tumor, Sertoli cell tumor)]
    Mutsushi Kawakita
    Department of Urology, Kobe City General Hospital
    Nihon Rinsho . 2006
  44. ncbi A painless testicular mass in a 50-year-old man. Leydig cell tumor of the testis, microcystic variant
    Emily Loyd
    Department of Pathology, Weill Cornell Medical College, New York, NY 10021, USA
    Arch Pathol Lab Med 130:e39-40. 2006
  45. ncbi The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors
    John J Liang
    Department of Pathology, New York University School of Medicine, NY, USA
    J Urol 177:1918-22. 2007
    ..We studied the expression of p44 and protein arginine methyltransferase 5 in developing fetal testis and adult testicular tumors, including seminomas and Leydig cell tumors...
  46. pmc Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases
    Tetsuya Mizutani
    Department of Pharmacology, 2 319B BSB, 51 Newton Road, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Mol Endocrinol 20:619-30. 2006
    ....
  47. ncbi Cytologic features of testicular tumours in dog
    C Masserdotti
    Clinica Veterinaria S Antonio, via Montale 2, Salò BS, Italy
    J Vet Med A Physiol Pathol Clin Med 52:339-46. 2005
    ..The specificity was 100% for all three tumour types. In our experience cytology of fine needle aspirations of testicular tumours is a very reliable technique...
  48. ncbi Effects of Tremella mesenterica on steroidogenesis in MA-10 mouse Leydig tumor cells
    H C Lo
    Department of Medical Education and Research, Changhua Christian Hospital, Changhua, Taiwan, Republic of China
    Arch Androl 51:285-94. 2005
    ..Taken together, present studies suggested that TM suppressed hCG-treated steroidogenesis in MA-10 cells without any toxicity effect...
  49. pmc A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice
    Gabriel Bodek
    Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10 714, Poland
    Neoplasia 7:497-508. 2005
    ..These results prove the principle that the Hecate-CGbeta conjugate provides a novel specific lead into gonadal somatic cell cancer therapy by targeted destruction of LHR-expressing tumor cells...
  50. ncbi Testicular-sparing microsurgery for suspected testicular masses
    Giovanni Maria Colpi
    Andrology Unit, San Paolo Hospital, Milan, Italy
    BJU Int 96:67-9. 2005
    ..To describe a microsurgical technique for removing suspected testicular masses with sparing of the testicular parenchyma, and to describe case studies...
  51. ncbi Dual role of histamine in modulation of Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes
    Carolina Mondillo
    Lab of Molecular Endocrinology and Signal Transduction, Institute of Biology and Experimental Medicine CONICET, CP 1428, Buenos Aires, Argentina
    Biol Reprod 73:899-907. 2005
    ....
  52. ncbi Non-tumoural parenchyma in Leydig cell tumours: pathogenetic considerations
    M M Cajaiba
    Department of Pathology, Hospital La Paz, Universidad Autonoma de Madrid, Madrid, Spain
    Int J Androl 31:331-6. 2008
    ..The significance of these associations merits further investigation regarding a common pathogenesis...
  53. ncbi Effects of overexpression of CXCL10 (cytokine-responsive gene-2) on MA-10 mouse Leydig tumor cell steroidogenesis and proliferation
    Madan L Nagpal
    Research Service, W J B Dorn Veterans Medical Center, Columbia, South Carolina 29209, USA
    J Endocrinol 183:585-94. 2004
    ..CXCL10 has the potential to be used in gene therapy for prostate cancer due to its antiangiogenic effect and its inhibitory effect on steroidogenesis...
  54. ncbi Gene and protein profiling of the response of MA-10 Leydig tumor cells to human chorionic gonadotropin
    Wenping Li
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Basic Sciences Bldg, 3900 Reservoir Rd, Washington, DC 20057, USA
    J Androl 25:900-13. 2004
    ....
  55. ncbi Feasibility of simultaneous testicular microdissection for sperm retrieval and ipsilateral testicular tumor resection in azoospermic men
    Saleh Binsaleh
    Department of Urology, Royal Victoria Hospital, McGill University Health Center, 687 Pine Ave West, S6 95, Montreal, Quebec H3A 1A1, Canada
    J Androl 25:867-71. 2004
  56. ncbi Detection of testicular ultrasonographic lesions in severe male infertility
    Luca Carmignani
    Urology Unit, Department of Medicine, Surgery and Dental Sciences, University of Milan, San Paolo Hospital, Via Antonio Di Rudini 8, 20142 Milan, Italy
    J Urol 172:1045-7. 2004
    ..We retrospectively assessed the number and histology of testicular lesions diagnosed clinically and by ultrasonography in a population of infertile men...
  57. ncbi Low temperature blocks the stimulatory effect of human chorionic gonadotropin on steroidogenic acute regulatory protein mRNA and testosterone production but not cyclic adenosine monophosphate in mouse Leydig tumor cells
    N S Panesar
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    Metabolism 53:955-8. 2004
    ..Although hibernation may lead to decreased steroid hormone production, it is also likely that cold-mediated decreased steroid hormone production induces hibernation...
  58. ncbi Surgery in infants and children with testicular and paratesticular tumours: a single centre experience over a 25-year-period
    R B Tröbs
    Kinderchirurgische Klinik, Marienhospital Herne, Ruhr Universitat Bochum, Widumer Strasse 8, 44627 Herne
    Klin Padiatr 219:146-51. 2007
    ..3. The presence of sufficient healthy testicular parenchyma. However, the high rate of malignant or potentially malignant tumours suggests that high inguinal orchidectomy should remain the surgical standard of therapy...
  59. ncbi [Gynaecomastia and male infertility as symptoms of a nonpalpable Leydig cell tumour]
    J E van de Riet
    Academisch Medisch Centrum Universiteit van Amsterdam, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:1839-43. 2006
    ..Besides history taking, physical examination of breasts and testicles, hormonal screening and scrotal sonography should be performed as some testicular neoplasms are not apparent on palpation...
  60. ncbi Effects of amphetamine on steroidogenesis in MA-10 mouse Leydig tumor cells
    Liang Yu Chen
    Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Life Sci 72:1983-95. 2003
    ..05). These results suggested that amphetamine enhanced hCG-induced progesterone production in MA-10 cells by increasing P450scc activity without influencing StAR protein and P450scc enzyme expression or 3beta-HSD enzyme activity...
  61. ncbi Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells
    Zhifang Zhang
    Population Council, New York, New York 10021, USA
    Endocrinology 143:829-36. 2002
    ..The inhibitory effect on GATA-1 gene expression was specific to testicular cells and was not observed in erythroid cells...
  62. ncbi Testicular tumors in children
    A O Ciftci
    Departments of Pediatric Surgery and Pediatric Oncology, Hacettepe University Medical Faculty, Ankara, Turkey
    J Pediatr Surg 36:1796-801. 2001
    ..trends emphasize that testis-sparing surgery should be performed for benign lesions such as teratoma, leydig cell tumor, and epidermoid cyst based on frozen biopsy findings...
  63. ncbi Immunohistochemical detection of inhibin-alpha, -betaB, and -betaA chains and 3beta-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes
    H Taniyama
    Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Vet Pathol 38:661-6. 2001
    ..The concentration of inhibin in the plasma was markedly decreased by the surgical removal of the Leydig cell tumor in one dog...
  64. ncbi Immunohistochemical analysis of cyclins in canine normal testes and testicular tumors
    Y Murakami
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Gakuen Kibana Dai, Japan
    J Vet Med Sci 63:909-12. 2001
    ..High levels of cyclin A expression in canine seminomas indicate that the neoplastic germ cells may be arrested at the spermatogonia and primary spermatocyte stages of differentiation...
  65. ncbi Growth-arrest and inhomogenous echotexture of the affected testis after tumor enucleation for unilateral Leydig cell tumor
    R B Tröbs
    Departments of Pediatric Surgery, Pediatrics, and Pathology, University of Leipzig, Germany
    J Pediatr Surg 36:E20. 2001
    The authors report on an 8-year-old boy with unilateral left-sided Leydig cell tumor. After enucleation of the tumor, endocrine disturbances resolved...
  66. ncbi Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors
    A Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Biochem Biophys Res Commun 285:400-8. 2001
    ..These observations suggest a role of TSKS in testicular physiology, most probably in the process of spermatogenesis or spermiogenesis...
  67. ncbi GATA DNA-binding protein expressed in mouse I-10 Leydig testicular tumor cells
    R Nakagawa
    Laboratory of Biochemistry and Molecular Biology, Osaka University, Osaka, Suita, 565-0871, Japan
    Biochem Biophys Res Commun 283:412-6. 2001
    ..Thus the conserved zinc finger domain of GATA proteins is suggested to contribute to the binding sequence preference. GATA-4 expressed in I-10 cells was not susceptible to proteolysis coupled with cAMP signaling...
  68. ncbi Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene
    - Rilianawati
    Department of Physiology, University of Turku, Finland
    Mol Endocrinol 12:801-9. 1998
    ..In conclusion, the high level of functional LHR in the adrenal tumors indicates that this receptor can function as tumor promoter when ectopically expressed and stimulated by the ligand hormone...
  69. ncbi Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein
    P R Manna
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 140:1739-51. 1999
    ..The stimulatory effect of hCG that rapidly increases [Ca2+]i is responsible at least in part for the regulation of SF-1-mediated StAR expression that consequently regulates steroidogenesis in mouse Leydig tumor cells...
  70. ncbi Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor
    G Liu
    Department of Pediatrics, Northwestern University Medical School and Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    N Engl J Med 341:1731-6. 1999
  71. ncbi Spermatogenesis and testicular tumours in ageing dogs
    M A Peters
    Department of Cell Biology, University Medical Centre, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Reprod Fertil Suppl 57:419-21. 2001
    ..In conclusion, it appears that spermatogenesis per se does not decrease during ageing in dogs. However, the occurrence of testicular tumours increases with age and this may affect spermatogenesis significantly...
  72. ncbi Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors
    J Sanchez-Yague
    Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242 1109
    Endocrinology 132:1007-16. 1993
    ..A change in the functional properties of the gonadotropin receptors appears to be the most likely mechanism for desensitization...
  73. ncbi Biphasic action of prolactin in the regulation of murine Leydig tumor cell functions
    P R Manna
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
    Endocrinology 142:308-18. 2001
    ..Collectively, these findings clearly demonstrate the biphasic regulatory actions of PRL, and clarify some facets of the controversial role of this hormone in Leydig cell function...
  74. ncbi Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport
    Rekha M Rao
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 68:114-21. 2003
    ....
  75. ncbi Mechanisms of epidermal growth factor signaling: regulation of steroid biosynthesis and the steroidogenic acute regulatory protein in mouse Leydig tumor cells
    Pulak R Manna
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 67:1393-404. 2002
    ..These findings provide novel insights into the mEGF-induced regulatory cascades associated with steroid synthesis and StAR protein expression in mouse Leydig cells...
  76. ncbi Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis
    Yukichi Tanaka
    Division of Pathology, Kanagawa Children s Medical Center, Yokohama, Japan
    Hum Pathol 33:285-9. 2002
    ....
  77. ncbi The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia
    D Lin
    Department of Pediatrics, University of California at San Francisco 94143 0978
    Genomics 18:643-50. 1993
    ..RT-PCR analysis of testicular RNA from such a patient, sequencing of the cDNA, and blotting analysis of genomic DNA all indicate that the gene and mRNA for the PBR component of mBzR are normal in this disease...
  78. doi Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors
    Chengquan Zhao
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 33:354-66. 2009
    ..of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25)...
  79. ncbi OCT4: a novel biomarker for dysgerminoma of the ovary
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:1341-6. 2004
    ..All nondysgerminomatous tumors (mature teratoma, 14; yolk sac tumor, 4; Sertoli-Leydig cell tumor, 15; granulosa cell tumor, 22; Brenner tumor, 3; carcinoid tumor, 4; struma ovarii, 2; fibroma, 5; thecoma, ..
  80. doi Clinical syndromes associated with ovarian neoplasms: a comprehensive review
    Alampady Krishna Prasad Shanbhogue
    Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Radiographics 30:903-19. 2010
    ..with either hyperestrogenism (as in granulosa cell tumor and thecoma) or hyperandrogenism (as in Sertoli-Leydig cell tumor and Leydig cell tumor)...
  81. ncbi Localization of the steroidogenic acute regulatory protein in human tissues
    S E Pollack
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Endocrinol Metab 82:4243-51. 1997
    ..Ovaries with hyperthecosis contained areas of intense thecal staining. An ovarian Leydig cell tumor stained intensely, whereas granulosa cell tumors were negative...
  82. ncbi Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli-Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the
    Katarzyna Jarzabek
    Department of Reproduction and Gynaecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
    Gynecol Endocrinol 23:499-504. 2007
    ..Testicular tumors such as Sertoli-Leydig cell tumor often develop in patients with CAIS...
  83. ncbi CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 26:322-7. 2007
    ..granulosa cell tumor (n = 40), juvenile granulosa cell tumor (n = 8), Sertoli cell tumor (n = 1), Sertoli-Leydig cell tumor (n = 14), Leydig cell tumor (n = 2), steroid cell tumor, not otherwise specified (n = 2), sclerosing stromal ..
  84. ncbi Tumors of the parathyroid gland and circulating parathyroid hormone-related protein associated with persistent hypercalcemia
    T J Rosol
    Ohio State University, Department of Veterinary Pathobiology, Columbus43210
    Toxicol Pathol 17:346-56. 1989
    ..Well characterized animal models of HHM include a rat Leydig cell tumor line (Rice-500), the rat Walker mammary carcinosarcoma, and the canine apocrine adenocarcinoma...
  85. ncbi Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant
    Catherine S Choong
    Department of Pediatric Endocrinology, Mater Misericordiae Hospitals, South Brisbane, Queensland 4104, Australia
    J Clin Endocrinol Metab 87:49-56. 2002
    ..who presented with a 4-month history of isosexual precocious puberty secondary to an estrogenizing Sertoli-Leydig cell tumor of the ovary...
  86. doi Retiform pattern of Sertoli-Leydig cell tumor of the ovary in a 4-year-old girl
    Vibha Kawatra
    Department of Pathology, Maulana Azad Medical College, New Dehli, India
    J Obstet Gynaecol Res 35:176-9. 2009
    ..Retiform pattern Sertoli-Leydig cell tumor seen mostly in young patients is clinically malignant and has a worse prognosis, underlining the importance ..
  87. doi Leydig-cell-tumor of the ovary that responded to GnRH-analogue administration - case report and review of the literature
    R K Klotz
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Exp Clin Endocrinol Diabetes 118:291-7. 2010
    ..The histologic examination revealed a Leydig cell tumor in the hilus and stroma of the left ovary...
  88. ncbi Granulosa cell tumor-like variant of endometrioid carcinoma of the ovary exhibiting nuclear clearing with biotin activity: a subtype showing close macroscopic, cytologic, and histologic similarity to adult granulosa cell tumor
    Mariko Fujibayashi
    Department of Surgical Pathology, Tokyo Women s Medical University Medical Center East, Tokyo, Japan
    Arch Pathol Lab Med 129:1288-94. 2005
    The sex cord-like variant of endometrioid carcinoma of the ovary shows many similarities to Sertoli-Leydig cell tumor and granulosa cell tumor...
  89. ncbi Non-germ-cell or teratomatous malignant tumors showing additional rhabdomyoblastic differentiation, with emphasis on the malignant Triton tumor
    J M Woodruff
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Semin Diagn Pathol 11:69-81. 1994
    ..tumors with rhabdomyosarcomatous differentiation are the carcinosarcoma, mullerian adenosarcoma, Sertoli-Leydig cell tumor, mammary cystosarcoma, and blastomas...
  90. ncbi Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis
    David Augusto
    Department of Pathology, University Hospitals, Lille, France
    Appl Immunohistochem Mol Morphol 10:159-62. 2002
    Sex cord-stromal tumors represent approximately 4% of all testicular neoplasms. Leydig cell tumor (LCT) is the most common entity, followed by Sertoli cell tumor (SCT)...
  91. ncbi Gynandroblastoma with elements resembling juvenile granulosa cell tumor
    J R Broshears
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Int J Gynecol Pathol 16:387-91. 1997
    ..reported tumors, adult granulosa cell tumor has formed the ovarian-type component and Sertoli or Sertoli-Leydig cell tumor (SLCT) has formed the testicular-type component...
  92. ncbi Functioning ovarian tumors: direct and indirect findings at MR imaging
    Yumiko O Tanaka
    Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Radiographics 24:S147-66. 2004
    ..Conversely, Sertoli-Leydig cell tumor is representative of hormone-producing tumors that cause virilization...
  93. ncbi Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material
    Ugo De Giorgi
    Istituto Oncologico Romagnolo, Santa Maria delle Croci Hospital, Ravenna, Italy
    Oncology 64:370-3. 2003
    ..In very rare tumors, new methods, based on molecular and cytogenetic models, are requested to define recommended management...
  94. ncbi VASA is a specific marker for both normal and malignant human germ cells
    Anne Marie Zeeman
    Department of Pathology Laboratory for Experimental Patho Oncology, University Hospital of Rotterdam Daniel, Josephine Nefkens Institute, Erasmus University Rotterdam, The Netherlands
    Lab Invest 82:159-66. 2002
    ..carcinoma, teratoma, and yolk sac tumor) and derived cell lines, or nongerm cell tumors such as lymphoma or Leydig cell tumor. These results provide direct evidence that some germ cell tumors retain germ cell characteristics, whereas ..
  95. pmc Sertoli-Leydig cell tumor of the testis in a Sprague-Dawley rat
    Shin Wakui
    Toxicologic Pathology, Azabu University School of Veterinary Medicine, Kanagawa, Japan
    J Am Assoc Lab Anim Sci 47:67-70. 2008
    ..The presence of a thick or multilayered basement membrane was confirmed except in tumor-infiltrative lesions. The present case was considered to be a testicular mixed tubular Sertoli-Leydig cell tumor in a Sprague-Dawley rat.
  96. ncbi Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors
    Bernard Czernobilsky
    Patho Lab Laboratories, Ness Ziona, Israel
    Int J Gynecol Pathol 24:335-40. 2005
    We report a case of a retiform Sertoli-Leydig cell tumor of intermediate differentiation presenting as a uterine intracavity polypoid mass in a 63-year-old woman...
  97. ncbi Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors
    V N Demidov
    Federal Governmental Institution Science Center of Obstetrics, Gynecology and Perinatology of Russian Medical Technologies, Moscow, Russia
    Ultrasound Obstet Gynecol 31:85-91. 2008
    ..To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors...
  98. ncbi [Diagnostic value of immunohistochemistry in ovarian sex cord-stromal tumors]
    Faten Farah-Klibi
    Service d Anatomie Pathologique, Hopital Charles Nicolle, Tunis, Tunisie
    Tunis Med 86:821-6. 2008
    ..The ovarian tumors' diagnosis is based on biological and radiologic tests but only the histological examination associated to an immunohistochemical study allow best diagnosis...
  99. doi Granulosa cell tumors of the ovary with a pseudopapillary pattern: a study of 14 cases of an unusual morphologic variant emphasizing their distinction from transitional cell neoplasms and other papillary ovarian tumors
    Julie A Irving
    Department of Laboratory Medicine, Royal Jubilee Hospital, Victoria, Canada
    Am J Surg Pathol 32:581-6. 2008
    ..pathologist favored a diagnosis of a transitional cell neoplasm in 3 of these cases, and a retiform Sertoli-Leydig cell tumor in 2 cases; in most of the remainder, the diagnosis of granulosa cell tumor was considered but uncertainty ..
  100. ncbi Possible mechanism for testicular focal necrosis induced by hCG in rats
    Fumio Chatani
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Co Ltd, Osaka, Japan
    J Toxicol Sci 31:291-303. 2006
    ..Necrosis of spontaneously-induced Leydig cell tumor mass was also induced by hCG, suggesting that Leydig cells are responsible for induction of necrosis...
  101. doi Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements
    Paul N Staats
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Int J Gynecol Pathol 29:228-33. 2010
    ..neoplasm, in contrast with the other example of mucinous neoplasia associated with sex cord neoplasia, the Sertoli-Leydig cell tumor with heterologous elements, in which the "parent" neoplasm is likely the Sertoli-Leydig cell tumor.

Research Grants20

  1. HORMONAL REGULATION OF GAMETOGENESIS
    Marco Conti; Fiscal Year: 1993
    ..cAMP-PDEs in the Sertoli cell and in another gonadotropin-responsive system that we have established (MA-10 Leydig cell tumor line)...
  2. KCNRG gene as candidate tumor suppressor for CLL and MM
    Anna Baranova; Fiscal Year: 2005
    ..Common gene changes revealed by activation of KCNRG will be confirmed in Real-Time PCR experiments. ..
  3. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
    ..These workshops are an innovative way for scientists and teachers to work together to improve science education. ..
  4. PLATELET DERIVED GROWTH FACTOR IN FOLLICLE DEVELOPMENT
    Christopher Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  5. COX2-Regulated Testosterone Biosynthesis in Male Aging
    XingJia Wang; Fiscal Year: 2009
    ..abstract_text> ..