hyperglycemic hyperosmolar nonketotic coma

Summary

Summary: A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.

Top Publications

  1. ncbi [Hyperglycemic hyperosmolar nonketotic syndrome]
    Dagmara Reingardiene
    Clinic of Intensive Care, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:707-12; quiz 713-4,717. 2003
  2. pmc Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
  3. ncbi [Management of water electrolyte imbalance associated with diabetes mellitus]
    Koji Hasegawa
    Nihon Naika Gakkai Zasshi 92:784-9. 2003
  4. ncbi A 71-year-old man with hyperglycemia and mental status changes
    Christopher Naquin
    Louisiana State University Health Sciences Center, Family Practice Residency Program, New Orleans, USA
    J La State Med Soc 155:238-41. 2003
  5. ncbi Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients. Diagnosis and treatment
    Z Yared
    Division of Endocrinology, Metabolism and Nutrition, Research Centre, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Minerva Med 94:409-18. 2003
  6. doi Severe hyperglycemic hyperosmolar nonketotic coma in a nondiabetic patient receiving aripiprazole
    Lisa Marie Campanella
    Department of Emergency Medicine, St Joseph s Medical Center, Wayne, NJ, USA
    Ann Emerg Med 53:264-6. 2009
  7. ncbi Olanzapine-induced hyperglycemic hyperosmolar nonketotic coma: a case report
    Mariposa McCall
    J Clin Psychopharmacol 24:670-3. 2004
  8. ncbi Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Endocrinol Metab Clin North Am 35:725-51, viii. 2006
  9. ncbi Diabetic emergencies in adults
    Tina Moore
    School of Health and Social Sciences, Middlesex University, Middlesex
    Nurs Stand 18:45-52; quiz 54. 2004
  10. ncbi A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus
    Elizabeth A Koller
    Division of Metabolic and Endocrine Drug Products, Center for Drug Evaluation and Review, US Food and Drug Administration, Rockville, MD, USA
    J Clin Psychiatry 65:857-63. 2004

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. ncbi [Hyperglycemic hyperosmolar nonketotic syndrome]
    Dagmara Reingardiene
    Clinic of Intensive Care, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:707-12; quiz 713-4,717. 2003
    ..A discussion of complications management of hyperosmolar hyperglycemia, mortality rate and prevention are included in this review...
  2. pmc Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
    ..The diagnosis is confirmed by the blood pH, serum bicarbonate level and serum osmolality. Treatment consists of adequate correction of the dehydration, hyperglycemia, ketoacidosis and electrolyte deficits...
  3. ncbi [Management of water electrolyte imbalance associated with diabetes mellitus]
    Koji Hasegawa
    Nihon Naika Gakkai Zasshi 92:784-9. 2003
  4. ncbi A 71-year-old man with hyperglycemia and mental status changes
    Christopher Naquin
    Louisiana State University Health Sciences Center, Family Practice Residency Program, New Orleans, USA
    J La State Med Soc 155:238-41. 2003
    ..We report herein a patient presenting with hyperglycemic hyperosmolar coma with three possible precipitating infections: pharyngitis, urinary tract infection, and infective endocarditis...
  5. ncbi Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients. Diagnosis and treatment
    Z Yared
    Division of Endocrinology, Metabolism and Nutrition, Research Centre, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Minerva Med 94:409-18. 2003
    ..Excess mortality still occurs, particularly for HHS, emphasizing the importance of patient education and regular follow-up to prevent these potentially fatal complications...
  6. doi Severe hyperglycemic hyperosmolar nonketotic coma in a nondiabetic patient receiving aripiprazole
    Lisa Marie Campanella
    Department of Emergency Medicine, St Joseph s Medical Center, Wayne, NJ, USA
    Ann Emerg Med 53:264-6. 2009
    ..We present a case of a patient without a history of diabetes mellitus who presented to the emergency department in severe hyperosmolar nonketotic coma while using aripiprazole...
  7. ncbi Olanzapine-induced hyperglycemic hyperosmolar nonketotic coma: a case report
    Mariposa McCall
    J Clin Psychopharmacol 24:670-3. 2004
  8. ncbi Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Endocrinol Metab Clin North Am 35:725-51, viii. 2006
    ..DKA and HHS also are economically burdensome; therefore, any resources invested in their prevention would be rewarding...
  9. ncbi Diabetic emergencies in adults
    Tina Moore
    School of Health and Social Sciences, Middlesex University, Middlesex
    Nurs Stand 18:45-52; quiz 54. 2004
    ..In this article the author discusses three diabetic emergencies: diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and hypoglycaemia, which all require prompt recognition and appropriate intervention...
  10. ncbi A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus
    Elizabeth A Koller
    Division of Metabolic and Endocrine Drug Products, Center for Drug Evaluation and Review, US Food and Drug Administration, Rockville, MD, USA
    J Clin Psychiatry 65:857-63. 2004
    ..To explore the clinical characteristics of hyperglycemia in patients treated with quetiapine...
  11. pmc Hyperglycaemic crises and lactic acidosis in diabetes mellitus
    P English
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Postgrad Med J 80:253-61. 2004
    ..As far as is possible, the recommendations are based on clear published evidence; failing that, what is considered to be a common sense synthesis of consensus guidelines and recommendations is provided...
  12. ncbi Pathophysiology of diabetes mellitus
    Richard A Guthrie
    Mid America Diabetes Associates, 200 S Hillside, Wichita, KS 67211, USA
    Crit Care Nurs Q 27:113-25. 2004
    ..and symptoms to be aware of when the person is in the acute state of diabetic ketoacidosis, hyperglycemic hyperosmolar nonketotic coma (or state), and severe hypoglycemia...
  13. ncbi Hyperglycemic crisis. Regaining control
    Veronica Crump
    Morristown Memorial Hospital, Morristown, N L, USA
    RN 67:23-4, 26-7; quiz 28. 2004
  14. ncbi Death caused by hyperglycemic hyperosmolar state at the onset of type 2 diabetes
    Alba E Morales
    Division of Pediatric Endocrinology, University of Florida College of Medicine, Gainesville, Florida 32608 1153, USA
    J Pediatr 144:270-3. 2004
    ..All had previously unrecognized type 2 diabetes, and death may have been prevented with earlier diagnosis or treatment...
  15. ncbi Management of hyperglycemic emergencies
    Zara R Brenner
    Department of Nursing, State University of New York at Brockport and Rochester General Hospital, 14621, USA
    AACN Clin Issues 17:56-65; quiz 91-3. 2006
    ....
  16. ncbi [Hyperglycemic hyperosmolar non-ketotic coma]
    Kazuhiro Hiramine
    The Third Department of Internal Medicine, Tokyo Medical University
    Nihon Rinsho . 2006
  17. ncbi Can you rapidly distinguish these endocrine emergencies?
    Kim Pearson
    RN 69:49. 2006
  18. ncbi Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus
    Brendan J Kilbane
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
    Pediatr Crit Care Med 7:169-73. 2006
    ..However, a fatal malignant hyperthermia-like syndrome (MHLS) with rhabdomyolysis associated with new-onset diabetes mellitus and HHNS in adolescents has been described...
  19. pmc Nontraumatic rhabdomyolysis: an unusual complication of diabetic hyperosmolar nonketotic (HONK) state
    K K Gangopadhyay
    Medicine, Diabetes and Endocrinology, City Hospital, Manchester
    J R Soc Med 99:200. 2006
  20. ncbi Acute necrotizing pancreatitis in an adolescent with type 2 diabetes
    Orit Pinhas-Hamiel
    Pediatric Endocrinology and Diabetes, Sheba Medical Center, Ramat Gan and Maccabi Juvenile Diabetes Center, Raanana, Israel
    Curr Opin Pediatr 18:206-8. 2006
    ..Since adolescents with type 2 diabetes are susceptible to the same complications that accompany type 2 diabetes in adults, pediatricians are now encountering new diagnosis entities...
  21. ncbi Pediatric hyperglycemic hyperosmolar syndrome: diagnostic difficulties and high mortality rate
    Joel B Cochran
    Pediatric Department, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Emerg Med 24:297-301. 2006
    ..Of the 18 cases, there were 13 deaths (72%). The purpose of this report and literature review is to emphasize the importance of early diagnoses and treatment of pediatric HHS...
  22. ncbi Hyperglycemic crises: improving prevention and management
    Abbas E Kitabchi
    Am Fam Physician 71:1659-60. 2005
  23. ncbi Diabetic emergencies
    Lynda Latham
    University Hospital, North Staffordshire
    Nurs Stand 19:64. 2005
  24. ncbi [Diabetic metabolic emergencies]
    Zoltan Balogh
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Általános Orvostudományi Kar, Belgyógyászati Intézet, I Belgyógyászati Klinika, Anyagcsere betegségek Tanszék
    Orv Hetil 146:443-50. 2005
    ..The authors summarize clinical presentation and therapeutic possibilities of hypoglycaemia on the basis of the literature...
  25. ncbi New-onset type II diabetes mellitus, hyperosmolar non-ketotic coma, rhabdomyolysis and acute renal failure in a patient treated with sulpiride
    Omer Toprak
    Nephrol Dial Transplant 20:662-3. 2005
  26. pmc A case of hyperglycemic hyperosmolar state associated with Graves' hyperthyroidism: a case report
    Sung Won Moon
    Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
    J Korean Med Sci 21:765-7. 2006
    ..Here, we described the case of a woman with Graves' disease and type 2 DM developing to HHS...
  27. ncbi A new challenge in pediatric obesity: pediatric hyperglycemic hyperosmolar syndrome
    Rebecca M Carchman
    Pediatric Critical Care Fellow, University of North Carolina Hospital, Chapel Hill, NC, USA
    Pediatr Crit Care Med 6:20-4. 2005
    ..To describe four adolescents with hyperglycemic hyperosmolar syndrome, an uncommon presentation of type 2 diabetes in pediatric patients...
  28. ncbi [Diabetic hyperosmolality. Retrospective study of 60 cases]
    Maria Vitor Campos
    Serviço Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra
    Acta Med Port 16:13-9. 2003
    ....
  29. ncbi Hyperosmolar hyperglycemic state of pregnancy with intrauterine fetal demise and preeclampsia
    Juan M Gonzalez
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Perinatol 24:541-3. 2007
    ..The practitioner should have a high index of suspicion for HHS in obese patients presenting with hyperglycemia...
  30. ncbi Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males
    Abby S Hollander
    Division of Pediatric Endocrinology and Metabolism, Washington University School of Medicine and St Louis, Children s Hospital, St Louis, MO 63110, USA
    Pediatrics 111:1447-52. 2003
    ..The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability...
  31. ncbi Diabetes emergencies in the patient with type 2 diabetes
    L Quinn
    Department of Medical-Surgical Nursing, University of Illinois at Chicago College of Nursing, Chicago, Illinois 60612, USA
    Nurs Clin North Am 36:341-60, viii. 2001
    ..This article explores the acute complications of type 2 diabetes and some of the issues associated with managing these patients in the hospital setting...
  32. pmc Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, 920 Madison Avenue 909, Memphis, TN 38163, USA
    J Clin Endocrinol Metab 93:1541-52. 2008
    ..This paper summarizes the results of these prospective studies on the management and pathophysiology of DKA...
  33. doi Diabetic ketoacidosis and hyperglycaemic hyperosmolar syndrome - clinical guidelines
    Karen de Beer
    ICU, Royal Free Hampstead NHS Trust, London, UK
    Nurs Crit Care 13:5-11. 2008
    ..The admission of patients to the intensive care unit (ICU) with DKA and HHS is rare, and management of patients' diverse problems is prone to error because of a lack of familiarity...
  34. ncbi Influence of age on the presentation and outcome of acidotic and hyperosmolar diabetic emergencies
    R J MacIsaac
    Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
    Intern Med J 32:379-85. 2002
    ..Traditionally, DKA and HHS have been classified as distinct entities but there is evidence to suggest that patients can present with elements of both conditions...
  35. ncbi Hyperosmolar hyperglycaemic nonketotic coma associated with acute myocardial infarction: report of three cases
    Mustafa Yildiz
    Trakya University, School of Medicine, Cardiology Department, Edirne, Turkey
    Acta Cardiol 57:271-4. 2002
    ..This article presents three patients with this association and aimed to discuss the clinical course and treatment strategies of this rare condition...
  36. ncbi [Our experience in continuous administration of insulin using infusion dispenser at a metabolic intensive care unit (MICU)]
    J Charvat
    Jednotka intenzivní metabolické péce Interní kliniky 2 lékarské fakulty UK a FN Motol, Praha
    Vnitr Lek 53:1047-52. 2007
    ....
  37. ncbi Hyperosmolar hyperglycemic state
    Gregg D Stoner
    University of Illinois College of Medicine, Peoria, Illinois 61602, USA
    Am Fam Physician 71:1723-30. 2005
    ..Finally, physicians should focus on preventing future episodes using patient education and instruction in self-monitoring...
  38. ncbi [Rhabdomyolysis in the diabetic state]
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital
    Nihon Rinsho 60:443-8. 2002
  39. ncbi Home health nursing care agenda based on health policy in Korea
    Hosihn Ryu
    College of Nursing, Korea University, Anam Dong, Sungbuk Ku, Seoul, South Korea
    Nurs Health Sci 7:92-8. 2005
    ..Accordingly, the major function and role of nursing policy makers in Korea is to develop an agenda and alternatives for policy-making in a systematic manner and to present implementation strategies clearly...
  40. doi Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples
    Joanna Hockenhull
    Toxicology Unit, Imperial College London, Charing Cross Hospital, London, United Kingdom
    Forensic Sci Int 214:142-7. 2012
    ....
  41. doi Epidemiology of hyperglycemic hyperosmolar syndrome in children hospitalized in USA
    Dayanand Bagdure
    Department of Pediatrics, University of Maryland School of Medicine, Division of Pediatric Critical Care Medicine, Baltimore, MD 21201, USA
    Pediatr Diabetes 14:18-24. 2013
    ..Previous studies of hyperglycemic hyperosmolar syndrome (HHS) in children are limited to case series or single-institution reviews, which describe HHS primarily in children with type 2 diabetes mellitus...
  42. ncbi Procedures and medications to help patients control their diabetes
    Maria del Carmen Garcia-Pascual
    Bronglais General Hospital, Aberystwyth, Ceredigion
    Emerg Nurse 20:30-5. 2012
    ..This article outlines the similarities and differences in the symptoms and treatment of the conditions, and discusses prevention strategies...
  43. doi Evidence-based management of hyperglycemic emergencies in diabetes mellitus
    Ebenezer A Nyenwe
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Diabetes Res Clin Pract 94:340-51. 2011
    ..The evidence for the role of preventive measures in DKA and HHS is also discussed. The unanswered questions and future research needs are also highlighted...
  44. ncbi Short-term case fatality rate and associated factors among inpatients with diabetic ketoacidosis and hyperglycemic hyperosmolar state: a hospital-based analysis over a 15-year period
    Hua Fen Chen
    Department of Endocrinology, Far Eastern Memorial Hospital, Taipei Hsien, Taiwan
    Intern Med 49:729-37. 2010
    ..Our aim was to evaluate the 28-day case-fatality rate among hospitalized DKA and HHS patients in a teaching hospital in Taiwan from 1991 to 2005...
  45. ncbi A successfully treated case of hyperosmolar hyperglycemic state complicated with rhabdomyolysis, acute kidney injury, and ischemic colitis
    Tomoko Izumi
    Depertment of Internal Medicine, Japan Self Defense Forces Central Hospital, Tokyo
    Intern Med 49:2321-6. 2010
    ..After surgery, his general condition improved. Careful monitoring of complications related to HHS is important...
  46. ncbi Hyperosmolar hyperglycaemic syndrome
    A Scott
    The Diabetes Centre, Northern General Hospital, Sheffield, UK
    Diabet Med 23:22-4. 2006
  47. ncbi Diabetic ketoacidosis and hyperosmolar hyperglycemic state
    Ioanna Gouni-Berthold
    Clinic II and Polyclinic for Internal Medicine, University of Cologne, Germany
    Med Klin (Munich) 101:100-5. 2006
    ..Improved patient education and implementation of measures such as home glucose and ketone monitoring might decrease the number of hospital admissions due to DKA and HHS, which are, in their majority, preventable)...
  48. doi Central pontine myelinolysis in a patient with epilepsia partialis continua and hyperglycaemic hyperosmolar state
    Shanying Mao
    Department of Neurology, Second Affiliated Hospital of Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou 310009, China
    Ann Clin Biochem 48:79-82. 2011
    ..This report is the first documented case of long-term hyperglycaemic hyperosmolar state leading to CPM, and highlights that CPM can present as an isolated hemiplegia...
  49. ncbi Predictors of hyperglycaemic crises and their associated mortality in Jamaica
    Stephanie T Chung
    Tropical Medicine Research Institute, University of West Indies, Mona, Jamaica
    Diabetes Res Clin Pract 73:184-90. 2006
    ..59; 95% CI: 1.24-10.41). Hence, hyperglycaemic crises in a Jamaican tertiary care hospital are associated with significant mortality especially in patients who are older or with altered mental status...
  50. ncbi [Hyperglycemic acute crisis in type 1 diabetes mellitus in youth]
    Durval Damiani
    Instituto da Criança, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Endocrinol Metabol 52:367-74. 2008
    ..DKA is still a high-mortality condition. And to be in a hurry frequently leads to neurologic sequelae and even to a fatal outcome...
  51. ncbi Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report
    Ekrem Dogan
    Department of Internal Medicine, Division of Nephrology, Yuzuncu Yil University, Van, Turkey
    Adv Ther 22:429-32. 2005
    ..The presumptive diagnosis on admission was nonketotic hyperosmolar syndrome precipitated by urinary infection. This is the first case report of hyperosmolar coma in a patient with type 1 diabetes with chronic kidney disease...
  52. ncbi Hyperosmolar hyperglycemic syndrome with rhabdomyolysis
    Mary E Stunkard
    Department of Clinical Sciences, Northern Michigan University, Marquette, MI 49855, USA
    Clin Lab Sci 24:8-13. 2011
    ..This patient was found to have nonketotic hyperosmolar hyperglycemia with concomitant rhabdomyolysis and myocardial infarction...
  53. doi Diabetic emergencies in small animals
    Mauria A O'Brien
    Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, 1008 West Hazelwood Drive, Urbana, IL 61802, USA
    Vet Clin North Am Small Anim Pract 40:317-33. 2010
    ..This article reviews the biochemical alterations contributing to these conditions, and discusses traditional and controversial management strategies...
  54. ncbi [Efficacy of total removal or subtotal removal combined gamma knife radiation on giant pituitary adenoma: a report of 160 cases]
    Qi Hua Xiao
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P R China
    Ai Zheng 26:742-7. 2007
    ..However, the outcome, especially for giant pituitary adenoma, is not very satisfactory. This study was to explore the efficacy of total tumor removal or subtotal tumor removal combined gamma knife radiation on giant pituitary adenoma...
  55. ncbi Ventricular septal rupture presenting with hyperosmolar hyperglycemic nonketotic coma
    Ersan Tatli
    Department of Cardiology, School of Medicine, Trakya University, Edirne, Turkey
    Saudi Med J 28:972-3. 2007
  56. ncbi Diabetes mellitus and periodontal disease
    Brian L Mealey
    Department of Periodontics, University of Texas Health Sciences Center at San Antonio, USA
    Periodontol 2000 44:127-53. 2007
  57. ncbi Type 2 diabetes in children and adolescents
    Chayim Y Newmark
    Saint Barnabas Medical Center Ambulatory Care Center, Livingston, New Jersey 07039, USA
    Pediatr Ann 36:109-13. 2007
  58. ncbi Hyperglycemic crises and their complications in children
    Arlan L Rosenbloom
    Division of Endocrinology, Department of Pediatrics, University of Florida College of Medicine, Children s Medical Services Center, 1701 SW 16th Avenue, Gainesville 32608, USA
    J Pediatr Endocrinol Metab 20:5-18. 2007
    ..The prevention of DKA and HHS at the onset of diabetes mellitus requires a high degree of awareness and suspicion by primary care providers; prevention of recurrent DKA necessitates a diligent team effort...
  59. ncbi [An elderly case of hyperglycemic hyperosmolar non-ketotic coma (HHNC)]
    Akio Kawakami
    Geriatrics and Vascular Medicine, Tokyo Medical and Dental University
    Nihon Ronen Igakkai Zasshi 44:756-60. 2007
    ..It is thought that a number of elderly diabetic patients who need insulin therapy do not receive or continue it for various reasons. Discussion is necessary to grasp the actual situation and defensive actions that can be taken...
  60. ncbi Extensive venous thrombosis of the upper extremity in a diabetic patient with a hyperosmolar hyperglycemic state
    Juri Park
    Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Korean J Intern Med 21:244-7. 2006
    ..Therefore, our patient was treated with early catheter-directed thrombolysis followed by anticoagulation...
  61. ncbi [Current status of costs and utilizations of hospital based home health nursing care in Korea]
    Hosihn Ryu
    College of Nursing, Korea University, Sungbuk Ku, Seoul, Korea
    Taehan Kanho Hakhoe Chi 36:1193-203. 2006
    ..The purpose of this study was to describe the current status of utilization and costs of home health nursing care by the levels of medical institutes in Korea...
  62. ncbi Acute postoperative metabolic complications of diabetes
    D Grimaud
    Département d Anesthésie Réanimation Est Hôpital Saint Roch, Nice, France
    Minerva Anestesiol 67:263-70. 2001
    ..as it would in an non diabetic patient. Lactic acidosis due to a treatment with metformin is now very rare and occurs almost only in patients having a contraindication to the use of metformin...
  63. doi Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature
    N Ahuja
    Wallsend Community Mental Health Team, Sir GB Hunter Hospital, Wallsend, Tyne and Wear, UK
    J Psychopharmacol 24:125-30. 2010
    ..These questions are considered in the context of currently available literature...
  64. doi Methods for the quantitative assessment of electrolyte disturbances in hyperglycaemia
    E Bartoli
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    Nutr Metab Cardiovasc Dis 19:67-74. 2009
    ..When Posm(1)=Posm(0), GA must equal the loss of ions induced by the osmotic diuresis (2 x DeltaNa), and the math solution is exact. We herein report data validating these new computational methods...
  65. doi Hyperosmolar coma due to exclusive glucose accumulation: recognition and computations
    Ettore Bartoli
    Internal Medicine, Department of Clinical and Experimental Medicine, Eastern Piedmont University, Novara, Italy
    Nephrology (Carlton) 14:338-44. 2009
    ....
  66. ncbi Case of the month. The details prevail
    Paul A Werfel
    University Medical Center, State University of New York, USA
    JEMS 31:36. 2006
  67. ncbi Very high cerebrospinal fluid protein in a patient with hyperosmolar coma
    Martin Rodriguez
    Am J Med 118:1437. 2005
  68. ncbi Hyperglycemic comas in children: new insights into pathophysiology and management
    Arlan L Rosenbloom
    Division of Endocrinology, Department of Pediatrics, College of Medicine, Children s Medical Services Center, University of Florida, 1701 SW 16th Avenue, Gainesville, 32608, USA
    Rev Endocr Metab Disord 6:297-306. 2005
  69. ncbi Tap-induced blink reflex and central nervous system dysfunction in diabetics with hyperosmolality
    Y Tachibana
    Department of Internal Medicine, Mejiro 2nd Hospital, Tokyo, Japan
    Eur Neurol 30:145-8. 1990
    ..In some patients with similar elevations in serum osmolality the R2' component was absent at a time when consciousness was preserved. Hence, TBR may be useful in monitoring CNS dysfunction in diabetics with hyperosmolality...
  70. ncbi [Diabetic coma. Management of diabetic ketoacidosis and nonketotic hyperosmolar coma]
    J Hensen
    Medizinische Klinik, Klinikum Hannover Nordstadt
    Internist (Berl) 44:1260-74. 2003
    ..With today's therapeutic possibilities the therapeutic goal, i.e. a low mortality, may be achieved, dependent on the underlying illness...
  71. ncbi Hyperglycaemic hyperosmolar syndrome in young obese Afro-Caribbean adults--a diagnostic dilemma. Report of two cases
    T M Ibrahim
    West Indian Med J 52:259. 2003
  72. ncbi Hyperosmolarity and acidosis in diabetes mellitus: a three-year experience in Rhode Island
    T J Wachtel
    Rhode Island Hospital, Providence 02903
    J Gen Intern Med 6:495-502. 1991
    ....
  73. ncbi [Acute complications due to diabetes mellitus: Hyperosmolar nonketotic coma]
    Koichi Kawanishi
    Kagawa Prefectural College of Health Sciences
    Nihon Rinsho 60:124-8. 2002
  74. ncbi [Proper help can save lives. Often symptoms are misinterpreted, nonetheless every second counts for the diabetic patient]
    Mario Hohenegger
    Pflege Aktuell 56:413-5. 2002
  75. ncbi Acute complications
    M Cypress
    Lovelace Health Systems, Albuquerque, USA
    RN 64:26-31; quiz 32. 2001
    ..You'll need to be able to quickly identify and know how to manage the acute complications of diabetes to help a patient avoid a tragic outcome. Here's how...
  76. ncbi Hyperglycemic crises in diabetes mellitus type 2
    D L Trence
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Endocrinol Metab Clin North Am 30:817-31. 2001
    ..Medications such as the protease inhibitors may in the future lead to a better understanding of the pathophysiology of the metabolic derangements seen in the development of type 2 diabetes mellitus...
  77. ncbi [Diabetic emergencies]
    W Berger
    Abteilung Endokrinologie, Kantonsspital Basel
    Praxis (Bern 1994) 86:308-13. 1997
    ..When the renal function is impaired, biguanide treatment is not indicated because of the risk of lactic acidosis. Most of the diabetic emergency situations are avoidable by proper education of the patients...
  78. ncbi One of the two genomic copies of the glycine decarboxylase cDNA has been deleted at a 5' region in a patient with nonketotic hyperglycinemia
    T Sakakibara
    Department of Biochemistry, Toyama Medical and Pharmaceutical University School of Medicine, Japan
    Biochem Biophys Res Commun 173:801-6. 1990
    ....
  79. ncbi Hyperosmolar nonketotic diabetic coma: diagnosis and management
    J T Braaten
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Geriatrics 42:83-8, 92. 1987
    ..Complications of therapy can be congestive heart failure secondary to excessive fluid administration, hypoglycemia if too much insulin is given, and hypokalemia if potassium is inadequately replaced...
  80. ncbi Diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma
    A E Kitabchi
    Division of Endocrinology and Metabolism, University of Tennessee, Memphis
    Med Clin North Am 72:1545-63. 1988
    ..The physiology of the fed and fasted state, evaluation, therapeutic issues, recommendations for therapy, immediate follow up care, and complications of therapy are reviewed for both syndromes...
  81. ncbi Fluid and electrolyte disorders associated with diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic coma
    D E Butts
    Mount Carmel Medical Center, Columbus, Ohio
    Nurs Clin North Am 22:827-36. 1987
    ..Assessment of the patient's knowledge about diabetes is essential so that proper education can be incorporated into his or her plan of care...
  82. ncbi Diabetic hyperosmolar non-ketotic decompensation
    M Small
    University Department of Medicine, Royal Infirmary, Glasgow
    Q J Med 66:251-7. 1988
    ....
  83. ncbi Lateral pontine and extrapontine myelinolysis associated with hypernatremia and hyperglycemia
    R D McComb
    Department of Pathology, University of Nebraska Medical Center, Omaha 68105
    Clin Neuropathol 8:284-8. 1989
    ..In both hypo- and hypernatremic states, the significant event may be an increase in serum sodium or serum osmolality of sufficient rapidity and magnitude...
  84. ncbi Treatment of hyperglycaemic hyperosmolar non-ketotic syndrome
    S N Levine
    Department of Medicine, Louisiana State University Medical Center, Shreveport
    Drugs 38:462-72. 1989
    ..This review discusses the current state of knowledge concerning the pathogenesis of HHNS, the clinical features of the disorder, and a systematic approach to treatment...
  85. ncbi Significance of increased serum elastase 1 level during the hyperosmolar hyperglycemic non-ketotic syndrome
    S Umeki
    Department of Medicine, Kawasaki Medical School, Okayama, Japan
    Hepatogastroenterology 34:212-4. 1987
    ..Rehydration therapy with half-normal saline solution immediately produced negative urine glucose, but the serum elastase 1 level only gradually normalized after improvement of HHNS...
  86. ncbi [Treatment of acute metabolic crisis in diabetes mellitus]
    Gyorgy Jermendy
    Bajcsy Zsilinszky Kórház, III Belgyógyászati Osztály, Budapest
    Orv Hetil 145:81-3. 2004
  87. ncbi Hyperosmolar non-ketotic diabetic syndrome associated with rhabdomyolysis and acute renal failure: a case report and review of literature
    T Ka
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Diabetes Nutr Metab 16:317-22. 2003
    ..This rare case is presented along with a review of literature...
  88. ncbi Reversibile quadriplegia and nonketotic hyperosmolar coma: is it an exceptional association or an overlooked complication?
    Attilio Allione
    Diabetes Care 27:1239-40. 2004
  89. ncbi Childhood diabetes presenting with hyperosmolar dehydration but without ketoacidosis: a report of three cases
    M J R Kershaw
    Birmingham Children s Hospital, Endocrinology and Diabetes, Birmingham, UK
    Diabet Med 22:645-7. 2005
    ..Hyperglycaemia and hyperosmolality without ketoacidosis has high mortality in adults, although there is no data on mortality in children...
  90. ncbi Hyperosmolar hyperglycemic state
    Bruce W Nugent
    Division of Emergency Medicine, Spectrum Health Butterworth, 100 Monroe NW, MC 49, Grand Rapids, MI 49503, USA
    Emerg Med Clin North Am 23:629-48, vii. 2005
    ..Identification of any precipitating illness is essential. The emergence of HHS as a critical presentation of type 2 diabetes mellitus in adolescents is highlighted...
  91. ncbi Common causes of hemiballism
    Hahn Shick Lee
    Am J Emerg Med 23:576-8. 2005
  92. ncbi Hyperosmolar hyperglycemic crisis: an acute life-threatening event in children and adolescents with type 2 diabetes mellitus
    Samar K Bhowmick
    Department of Pediatrics and Adolescent Medicine, Division of Endocrine and Metabolic Disease, University of South Alabama College of Medicine, Mobile, AL 36617 2297, USA
    Endocr Pract 11:23-9. 2005
    ....
  93. ncbi Hemorrhagic pituitary apoplexy in an 18 year-old male presenting as non-ketotic hyperglycemic coma (NKHC)
    Manmohan K Kamboj
    Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, USA
    J Pediatr Endocrinol Metab 18:611-5. 2005
    ..Data confirmed preoperative panhypopituitarism; serum prolactin was 396 ng/ml (microg/l). Immunostudies demonstrated tumoral labeling for prolactin, but not for ACTH, GH, TSH, LH, FSH, or P53...
  94. ncbi Insulin resistance in an 18-year-old patient with Down syndrome presenting with hyperglycaemic coma, hypernatraemia and rhabdomyolysis
    E J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Intern Med 258:285-8. 2005
  95. ncbi Therapeutic management of hyperglycaemic hyperosmolar syndrome
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    Expert Opin Pharmacother 6:1841-9. 2005
    ..This review provides an outline of the diagnostic approach of patients with manifestations of hyperglycaemic hyperosmolar syndrome and discusses the contemporary therapeutic recommendations...
  96. ncbi Diabetic emergencies
    Louise Hankin
    St Richards Hospital, Chichester
    Nurs Stand 19:67. 2005
  97. ncbi Hyperglycemic hyperosmolar nonketotic syndrome in a child with acute lymphoblastic leukemia undergoing induction chemotherapy: case report
    R Venkatraman
    Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, 160012 Chandigarh, India
    J Pediatr Hematol Oncol 27:234-5. 2005
    ..The syndrome has been rarely reported in children with leukemia undergoing induction therapy. The authors' aim is to sensitize physicians to this life-threatening illness, which can be treated effectively if diagnosed early...
  98. ncbi Cerebral edema without ketoacidosis or hyperosmolar coma in a 16-year- old boy
    Ram M Shastry
    Diabetes Care 28:753-4. 2005
  99. ncbi [Progress in diagnosis of and therapy for nonketotic hyperosmolar coma]
    Hiroshi Bando
    Nihon Naika Gakkai Zasshi 93:1513-8. 2004
  100. ncbi Nonketotic hyperosmolar coma associated with splenic rupture in congenital afibrinogenemia
    Mustafa Akcakus
    Paediatric Intensive Care Unit, Erciyes University, School of Medicine, Kayseri, Turkey
    J Pediatr Hematol Oncol 26:668-71. 2004
    ..Management consisted of correction of the nonketotic hyperosmolar condition and increasing fibrinogen concentration by blood products, followed by splenectomy, resulting in the survival of the patient...
  101. ncbi Overview of diabetes
    Joan K Bardsley
    MedStar Research Institute, 6495 New Hampshire Ave, Suite 201, Hyattsvile, MD 20783, USA
    Crit Care Nurs Q 27:106-12. 2004
    ..There are specific methods for recognition and treatment of both acute and chronic complications in the hospitalized patent with diabetes. Managing blood glucose control is essential for favorable outcomes...