hyperglycemic hyperosmolar nonketotic coma

Summary

Summary: A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.

Top Publications

  1. ncbi [Hyperglycemic hyperosmolar nonketotic syndrome]
    Dagmara Reingardiene
    Clinic of Intensive Care, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:707-12; quiz 713-4,717. 2003
  2. pmc Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
  3. ncbi [Management of water electrolyte imbalance associated with diabetes mellitus]
    Koji Hasegawa
    Nihon Naika Gakkai Zasshi 92:784-9. 2003
  4. ncbi A 71-year-old man with hyperglycemia and mental status changes
    Christopher Naquin
    Louisiana State University Health Sciences Center, Family Practice Residency Program, New Orleans, USA
    J La State Med Soc 155:238-41. 2003
  5. ncbi Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients. Diagnosis and treatment
    Z Yared
    Division of Endocrinology, Metabolism and Nutrition, Research Centre, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Minerva Med 94:409-18. 2003
  6. ncbi Severe hyperglycemic hyperosmolar nonketotic coma in a nondiabetic patient receiving aripiprazole
    Lisa Marie Campanella
    Department of Emergency Medicine, St Joseph s Medical Center, Wayne, NJ, USA
    Ann Emerg Med 53:264-6. 2009
  7. ncbi Deaths associated with diabetic ketoacidosis and hyperosmolar coma. 1973-1988
    P S Hamblin
    Ewen Downie Metabolic Unit, Monash University Department of Medicine, Alfred Hospital, Prahran, Vic
    Med J Aust 151:439, 441-2, 444. 1989
  8. ncbi Anticoagulant therapy in hyperosmolar non-ketotic diabetic coma
    K Kian
    Diabet Med 20:603. 2003
  9. ncbi Olanzapine-induced hyperglycemic hyperosmolar nonketotic coma: a case report
    Mariposa McCall
    J Clin Psychopharmacol 24:670-3. 2004
  10. ncbi Management of hyperglycemic emergencies
    Zara R Brenner
    Department of Nursing, State University of New York at Brockport and Rochester General Hospital, 14621, USA
    AACN Clin Issues 17:56-65; quiz 91-3. 2006

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. ncbi [Hyperglycemic hyperosmolar nonketotic syndrome]
    Dagmara Reingardiene
    Clinic of Intensive Care, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:707-12; quiz 713-4,717. 2003
    ..A discussion of complications management of hyperosmolar hyperglycemia, mortality rate and prevention are included in this review...
  2. pmc Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
    ..The diagnosis is confirmed by the blood pH, serum bicarbonate level and serum osmolality. Treatment consists of adequate correction of the dehydration, hyperglycemia, ketoacidosis and electrolyte deficits...
  3. ncbi [Management of water electrolyte imbalance associated with diabetes mellitus]
    Koji Hasegawa
    Nihon Naika Gakkai Zasshi 92:784-9. 2003
  4. ncbi A 71-year-old man with hyperglycemia and mental status changes
    Christopher Naquin
    Louisiana State University Health Sciences Center, Family Practice Residency Program, New Orleans, USA
    J La State Med Soc 155:238-41. 2003
    ..We report herein a patient presenting with hyperglycemic hyperosmolar coma with three possible precipitating infections: pharyngitis, urinary tract infection, and infective endocarditis...
  5. ncbi Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients. Diagnosis and treatment
    Z Yared
    Division of Endocrinology, Metabolism and Nutrition, Research Centre, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Minerva Med 94:409-18. 2003
    ..Excess mortality still occurs, particularly for HHS, emphasizing the importance of patient education and regular follow-up to prevent these potentially fatal complications...
  6. ncbi Severe hyperglycemic hyperosmolar nonketotic coma in a nondiabetic patient receiving aripiprazole
    Lisa Marie Campanella
    Department of Emergency Medicine, St Joseph s Medical Center, Wayne, NJ, USA
    Ann Emerg Med 53:264-6. 2009
    ..We present a case of a patient without a history of diabetes mellitus who presented to the emergency department in severe hyperosmolar nonketotic coma while using aripiprazole...
  7. ncbi Deaths associated with diabetic ketoacidosis and hyperosmolar coma. 1973-1988
    P S Hamblin
    Ewen Downie Metabolic Unit, Monash University Department of Medicine, Alfred Hospital, Prahran, Vic
    Med J Aust 151:439, 441-2, 444. 1989
    ....
  8. ncbi Anticoagulant therapy in hyperosmolar non-ketotic diabetic coma
    K Kian
    Diabet Med 20:603. 2003
  9. ncbi Olanzapine-induced hyperglycemic hyperosmolar nonketotic coma: a case report
    Mariposa McCall
    J Clin Psychopharmacol 24:670-3. 2004
  10. ncbi Management of hyperglycemic emergencies
    Zara R Brenner
    Department of Nursing, State University of New York at Brockport and Rochester General Hospital, 14621, USA
    AACN Clin Issues 17:56-65; quiz 91-3. 2006
    ....
  11. ncbi Influence of age on the presentation and outcome of acidotic and hyperosmolar diabetic emergencies
    R J MacIsaac
    Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
    Intern Med J 32:379-85. 2002
    ..Traditionally, DKA and HHS have been classified as distinct entities but there is evidence to suggest that patients can present with elements of both conditions...
  12. ncbi Diabetic emergencies in adults
    Tina Moore
    School of Health and Social Sciences, Middlesex University, Middlesex
    Nurs Stand 18:45-52; quiz 54. 2004
    ..In this article the author discusses three diabetic emergencies: diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and hypoglycaemia, which all require prompt recognition and appropriate intervention...
  13. pmc Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, 920 Madison Avenue 909, Memphis, TN 38163, USA
    J Clin Endocrinol Metab 93:1541-52. 2008
    ..This paper summarizes the results of these prospective studies on the management and pathophysiology of DKA...
  14. pmc Hyperglycaemic crises and lactic acidosis in diabetes mellitus
    P English
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Postgrad Med J 80:253-61. 2004
    ..As far as is possible, the recommendations are based on clear published evidence; failing that, what is considered to be a common sense synthesis of consensus guidelines and recommendations is provided...
  15. ncbi [Diabetic hyperosmolality. Retrospective study of 60 cases]
    Maria Vitor Campos
    Serviço Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra
    Acta Med Port 16:13-9. 2003
    ....
  16. ncbi Pathophysiology of diabetes mellitus
    Richard A Guthrie
    Mid America Diabetes Associates, 200 S Hillside, Wichita, KS 67211, USA
    Crit Care Nurs Q 27:113-25. 2004
    ..and symptoms to be aware of when the person is in the acute state of diabetic ketoacidosis, hyperglycemic hyperosmolar nonketotic coma (or state), and severe hypoglycemia...
  17. ncbi Hyperglycemic crisis. Regaining control
    Veronica Crump
    Morristown Memorial Hospital, Morristown, N L, USA
    RN 67:23-4, 26-7; quiz 28. 2004
  18. ncbi [Our experience in continuous administration of insulin using infusion dispenser at a metabolic intensive care unit (MICU)]
    J Charvat
    Jednotka intenzivní metabolické péce Interní kliniky 2 lékarské fakulty UK a FN Motol, Praha
    Vnitr Lek 53:1047-52. 2007
    ....
  19. ncbi Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Endocrinol Metab Clin North Am 35:725-51, viii. 2006
    ..DKA and HHS also are economically burdensome; therefore, any resources invested in their prevention would be rewarding...
  20. ncbi Diabetic emergencies
    Lynda Latham
    University Hospital, North Staffordshire
    Nurs Stand 19:64. 2005
  21. ncbi Diabetes emergencies in the patient with type 2 diabetes
    L Quinn
    Department of Medical-Surgical Nursing, University of Illinois at Chicago College of Nursing, Chicago, Illinois 60612, USA
    Nurs Clin North Am 36:341-60, viii. 2001
    ..This article explores the acute complications of type 2 diabetes and some of the issues associated with managing these patients in the hospital setting...
  22. ncbi Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus
    Brendan J Kilbane
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
    Pediatr Crit Care Med 7:169-73. 2006
    ..However, a fatal malignant hyperthermia-like syndrome (MHLS) with rhabdomyolysis associated with new-onset diabetes mellitus and HHNS in adolescents has been described...
  23. ncbi Can you rapidly distinguish these endocrine emergencies?
    Kim Pearson
    RN 69:49. 2006
  24. pmc A case of hyperglycemic hyperosmolar state associated with Graves' hyperthyroidism: a case report
    Sung Won Moon
    Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
    J Korean Med Sci 21:765-7. 2006
    ..Here, we described the case of a woman with Graves' disease and type 2 DM developing to HHS...
  25. ncbi Pediatric hyperglycemic hyperosmolar syndrome: diagnostic difficulties and high mortality rate
    Joel B Cochran
    Pediatric Department, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Emerg Med 24:297-301. 2006
    ..Of the 18 cases, there were 13 deaths (72%). The purpose of this report and literature review is to emphasize the importance of early diagnoses and treatment of pediatric HHS...
  26. ncbi Acute necrotizing pancreatitis in an adolescent with type 2 diabetes
    Orit Pinhas-Hamiel
    Pediatric Endocrinology and Diabetes, Sheba Medical Center, Ramat Gan and Maccabi Juvenile Diabetes Center, Raanana, Israel
    Curr Opin Pediatr 18:206-8. 2006
    ..Since adolescents with type 2 diabetes are susceptible to the same complications that accompany type 2 diabetes in adults, pediatricians are now encountering new diagnosis entities...
  27. pmc Nontraumatic rhabdomyolysis: an unusual complication of diabetic hyperosmolar nonketotic (HONK) state
    K K Gangopadhyay
    Medicine, Diabetes and Endocrinology, City Hospital, Manchester
    J R Soc Med 99:200. 2006
  28. ncbi [Hyperglycemic hyperosmolar non-ketotic coma]
    Kazuhiro Hiramine
    The Third Department of Internal Medicine, Tokyo Medical University
    Nihon Rinsho . 2006
  29. ncbi Hyperosmolar hyperglycemic state
    Gregg D Stoner
    University of Illinois College of Medicine, Peoria, Illinois 61602, USA
    Am Fam Physician 71:1723-30. 2005
    ..Finally, physicians should focus on preventing future episodes using patient education and instruction in self-monitoring...
  30. ncbi Home health nursing care agenda based on health policy in Korea
    Hosihn Ryu
    College of Nursing, Korea University, Anam Dong, Sungbuk Ku, Seoul, South Korea
    Nurs Health Sci 7:92-8. 2005
    ..Accordingly, the major function and role of nursing policy makers in Korea is to develop an agenda and alternatives for policy-making in a systematic manner and to present implementation strategies clearly...
  31. ncbi [Impairment of cardiac autonomic nervous system and incidence of arrhythmias in severe hyperglycemia]
    Sven Sufke
    Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Lubeck, Germany
    Med Klin (Munich) 105:858-70. 2010
    ..Moreover was evaluated how blood pressure, heart rate and incidence of arrhythmias can be explained by figures of heart rate variability...
  32. ncbi [Diabetic metabolic emergencies]
    Zoltan Balogh
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Általános Orvostudományi Kar, Belgyógyászati Intézet, I Belgyógyászati Klinika, Anyagcsere betegségek Tanszék
    Orv Hetil 146:443-50. 2005
    ..The authors summarize clinical presentation and therapeutic possibilities of hypoglycaemia on the basis of the literature...
  33. ncbi Diabetic ketoacidosis and hyperglycaemic hyperosmolar syndrome - clinical guidelines
    Karen de Beer
    ICU, Royal Free Hampstead NHS Trust, London, UK
    Nurs Crit Care 13:5-11. 2008
    ..The admission of patients to the intensive care unit (ICU) with DKA and HHS is rare, and management of patients' diverse problems is prone to error because of a lack of familiarity...
  34. pmc Evaluation of point-of-care blood glucose measurements in patients with diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome admitted to a critical care unit
    Dawn E Corl
    Clinical Education, Harborview Medical Center, 325 Ninth Ave, UW box 359733, Seattle, WA 98104 2499
    J Diabetes Sci Technol 7:1265-74. 2013
    ..Point-of-care (POC) blood glucose (BG) measurement is currently not recommended in the treatment of patients presenting with diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar syndrome (HHS)...
  35. ncbi Death caused by hyperglycemic hyperosmolar state at the onset of type 2 diabetes
    Alba E Morales
    Division of Pediatric Endocrinology, University of Florida College of Medicine, Gainesville, Florida 32608 1153, USA
    J Pediatr 144:270-3. 2004
    ..All had previously unrecognized type 2 diabetes, and death may have been prevented with earlier diagnosis or treatment...
  36. ncbi [Rhabdomyolysis in the diabetic state]
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital
    Nihon Rinsho 60:443-8. 2002
  37. ncbi Management of decompensated diabetes. Diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome
    M F Magee
    MedStar Diabetes Institute, Washington Hospital Center, Washington, DC, USA
    Crit Care Clin 17:75-106. 2001
    ....
  38. ncbi Hyperosmolar hyperglycemic state of pregnancy with intrauterine fetal demise and preeclampsia
    Juan M Gonzalez
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Perinatol 24:541-3. 2007
    ..The practitioner should have a high index of suspicion for HHS in obese patients presenting with hyperglycemia...
  39. ncbi Hyperosmolar non-ketotic syndrome in a child associated with l-asparaginase and prednisolone
    Bumin Dundar
    Department of Pediatric Endocrinology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey
    Pediatr Int 49:256-7. 2007
  40. ncbi Progressive vacuolating glycine leukoencephalopathy with pulmonary hypertension
    Mireia Del Toro
    Secció de Neurologia Infantil, Barcelona, Spain
    Ann Neurol 60:148-52. 2006
    ..The clinical and radiological evolution, as progressive vacuolating leukoencephalopathy and the association with pulmonary hypertension constitute a previously unrecognized variant...
  41. ncbi Hyperglycemic hyperosmolar non-ketotic syndrome in children with type 2 diabetes*
    Shannon H Fourtner
    Department of Pediatrics, Division of Endocrinology Diabetes, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Diabetes 6:129-35. 2005
    ..This study will serve to provide updated information regarding typical clinical course and sequelae of HHNK syndrome in childhood...
  42. ncbi A new challenge in pediatric obesity: pediatric hyperglycemic hyperosmolar syndrome
    Rebecca M Carchman
    Pediatric Critical Care Fellow, University of North Carolina Hospital, Chapel Hill, NC, USA
    Pediatr Crit Care Med 6:20-4. 2005
    ..To describe four adolescents with hyperglycemic hyperosmolar syndrome, an uncommon presentation of type 2 diabetes in pediatric patients...
  43. ncbi Hyperglycemic crises: improving prevention and management
    Abbas E Kitabchi
    Am Fam Physician 71:1659-60. 2005
  44. ncbi High risk for venous thromboembolism in diabetics with hyperosmolar state: comparison with other acute medical illnesses
    C R Keenan
    Division of General Internal Medicine, University of California, Davis, Sacramento, CA, USA
    J Thromb Haemost 5:1185-90. 2007
    ..However, clinical observations and case reports have suggested that patients with diabetes and hyperosmolarity may be at increased risk for VTE...
  45. ncbi Glycine encephalopathy (nonketotic hyperglycinaemia) : review and update
    D A Applegarth
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia
    J Inherit Metab Dis 27:417-22. 2004
    ..This article summarizes data and issues covered in the workshop on Glycine Encephalopathy using headings that cover important topics in our present knowledge of this disease...
  46. ncbi Continuous venovenous hemodiafiltration in hypernatremic hyperglycemic nonketotic coma
    Jen Jar Lin
    Division of Nephrology, Department of Pediatrics, Brody School of Medicine, East Carolina University, USA
    Pediatr Nephrol 17:969-73. 2002
    ..She had a full recovery of her renal function. She does not have clinical neurological sequelae from hypernatremia during a 1-year follow-up period...
  47. ncbi Nonketotic hypertonicity in diabetes mellitus
    D Lorber
    Department of Endocrinology, New York Hospital Medical Center of Queens, Flushing
    Med Clin North Am 79:39-52. 1995
    ..Most deaths from NKH occur in the first 2 days of hospitalization; therefore, a significant decrease in morbidity and mortality can be expected by education of patients and their caregivers in the prevention of NKH...
  48. ncbi [Methanol poisoning in a 61-year old male with recently diagnosed diabetes--a case report]
    Jarosław Szponar
    Samodzielny Publiczny Szpital Wojewódzki im Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej
    Przegl Lek 68:521-2. 2011
    ..The possibility of excessive consumption of aspartame and its metabolites causing methanol poisoning in the presented patient was considered...
  49. ncbi [Hyperglycemic hyperosmolar nonketotic coma]
    J Jaromczyk-Slisz
    II Kliniki Chorób Wewnetrznych Instytutu Chorób Wewnetrznych Ak Med w Gdańsku
    Wiad Lek 43:360-4. 1990
    ..Heparin was given with good effect. Three patients (30%) died in hospital. The cause of death was serious disease associated with this coma: pancreatitis and myocarditis, purulent bronchopneumonia, myocardial infarction...
  50. ncbi Cushing's syndrome manifesting as pseudo-central hypothyroidism and hyperosmolar diabetic coma
    Brent R Gooch
    MIMA Endocrinology, Melbourne, Florida 32901, USA
    Endocr Pract 8:119-23. 2002
    ..To report an unusual case of Cushing's syndrome caused by an adrenal pheochromocytoma, manifesting as pseudo-central hypothyroidism and diabetic hyperosmolar coma...
  51. ncbi New-onset type II diabetes mellitus, hyperosmolar non-ketotic coma, rhabdomyolysis and acute renal failure in a patient treated with sulpiride
    Omer Toprak
    Nephrol Dial Transplant 20:662-3. 2005
  52. ncbi Vital sign triage to rule out diabetic ketoacidosis and non-ketotic hyperosmolar syndrome in hyperglycemic patients
    Yasuharu Tokuda
    Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Diabetes Res Clin Pract 87:366-71. 2010
    ..To develop a prediction algorithm to rule out diabetic ketoacidosis (DKA) and non-ketotic hyperosmolar syndrome (NKHS) based on vital signs for early triage of patients with diabetes...
  53. ncbi Hyperosmolar diabetic non-ketotic coma, hyperkalaemia and an unusual near death experience
    J Y Ting
    Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Eur J Emerg Med 8:57-63. 2001
    ..Treatment of acute hyperkalaemia includes calcium ions, insulin with dextrose, salbutamol and haemodialysis...
  54. ncbi Transient nonketotic hyperglycinaemia: ultrasound, CT and MRI: case report
    J Alejo
    Neuroradiology 39:658-60. 1997
    ..Only 5 patients have been previously described with this transient from of nonketotic hyperglycinaemia. Among the radiographic findings, thinning of the corpus callosum is the most characteristic...
  55. ncbi Occipital lobe seizures related to marked elevation of hemoglobin A1C: report of two cases
    Wan Ling Hung
    Division of Neurology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Seizure 19:359-62. 2010
    ..We also suggest clinicians look for the presence of interictal focal beta paroxysms in addition to the usual epileptiform discharges while reading the EEG of these patients...
  56. ncbi Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males
    Abby S Hollander
    Division of Pediatric Endocrinology and Metabolism, Washington University School of Medicine and St Louis, Children s Hospital, St Louis, MO 63110, USA
    Pediatrics 111:1447-52. 2003
    ..The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability...
  57. ncbi Hyperosmolar hyperglycaemic nonketotic coma associated with acute myocardial infarction: report of three cases
    Mustafa Yildiz
    Trakya University, School of Medicine, Cardiology Department, Edirne, Turkey
    Acta Cardiol 57:271-4. 2002
    ..This article presents three patients with this association and aimed to discuss the clinical course and treatment strategies of this rare condition...
  58. ncbi A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus
    Elizabeth A Koller
    Division of Metabolic and Endocrine Drug Products, Center for Drug Evaluation and Review, US Food and Drug Administration, Rockville, MD, USA
    J Clin Psychiatry 65:857-63. 2004
    ..To explore the clinical characteristics of hyperglycemia in patients treated with quetiapine...
  59. ncbi Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples
    Joanna Hockenhull
    Toxicology Unit, Imperial College London, Charing Cross Hospital, London, United Kingdom
    Forensic Sci Int 214:142-7. 2012
    ....
  60. ncbi Epidemiology of hyperglycemic hyperosmolar syndrome in children hospitalized in USA
    Dayanand Bagdure
    Department of Pediatrics, University of Maryland School of Medicine, Division of Pediatric Critical Care Medicine, Baltimore, MD 21201, USA
    Pediatr Diabetes 14:18-24. 2013
    ..Previous studies of hyperglycemic hyperosmolar syndrome (HHS) in children are limited to case series or single-institution reviews, which describe HHS primarily in children with type 2 diabetes mellitus...
  61. ncbi Procedures and medications to help patients control their diabetes
    Maria del Carmen Garcia-Pascual
    Bronglais General Hospital, Aberystwyth, Ceredigion
    Emerg Nurse 20:30-5. 2012
    ..This article outlines the similarities and differences in the symptoms and treatment of the conditions, and discusses prevention strategies...
  62. ncbi Evidence-based management of hyperglycemic emergencies in diabetes mellitus
    Ebenezer A Nyenwe
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Diabetes Res Clin Pract 94:340-51. 2011
    ..The evidence for the role of preventive measures in DKA and HHS is also discussed. The unanswered questions and future research needs are also highlighted...
  63. ncbi Central pontine myelinolysis in a patient with epilepsia partialis continua and hyperglycaemic hyperosmolar state
    Shanying Mao
    Department of Neurology, Second Affiliated Hospital of Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou 310009, China
    Ann Clin Biochem 48:79-82. 2011
    ..This report is the first documented case of long-term hyperglycaemic hyperosmolar state leading to CPM, and highlights that CPM can present as an isolated hemiplegia...
  64. ncbi Hyperosmolar hyperglycemic syndrome with rhabdomyolysis
    Mary E Stunkard
    Department of Clinical Sciences, Northern Michigan University, Marquette, MI 49855, USA
    Clin Lab Sci 24:8-13. 2011
    ..This patient was found to have nonketotic hyperosmolar hyperglycemia with concomitant rhabdomyolysis and myocardial infarction...
  65. ncbi Hyperosmolar hyperglycaemic syndrome
    A Scott
    The Diabetes Centre, Northern General Hospital, Sheffield, UK
    Diabet Med 23:22-4. 2006
  66. ncbi A successfully treated case of hyperosmolar hyperglycemic state complicated with rhabdomyolysis, acute kidney injury, and ischemic colitis
    Tomoko Izumi
    Depertment of Internal Medicine, Japan Self Defense Forces Central Hospital, Tokyo
    Intern Med 49:2321-6. 2010
    ..After surgery, his general condition improved. Careful monitoring of complications related to HHS is important...
  67. ncbi [Current status of costs and utilizations of hospital based home health nursing care in Korea]
    Hosihn Ryu
    College of Nursing, Korea University, Sungbuk Ku, Seoul, Korea
    Taehan Kanho Hakhoe Chi 36:1193-203. 2006
    ..The purpose of this study was to describe the current status of utilization and costs of home health nursing care by the levels of medical institutes in Korea...
  68. ncbi Diabetic ketoacidosis and hyperosmolar hyperglycemic state
    Ioanna Gouni-Berthold
    Clinic II and Polyclinic for Internal Medicine, University of Cologne, Germany
    Med Klin (Munich) 101:100-5. 2006
    ..Improved patient education and implementation of measures such as home glucose and ketone monitoring might decrease the number of hospital admissions due to DKA and HHS, which are, in their majority, preventable)...
  69. ncbi Short-term case fatality rate and associated factors among inpatients with diabetic ketoacidosis and hyperglycemic hyperosmolar state: a hospital-based analysis over a 15-year period
    Hua Fen Chen
    Department of Endocrinology, Far Eastern Memorial Hospital, Taipei Hsien, Taiwan
    Intern Med 49:729-37. 2010
    ..Our aim was to evaluate the 28-day case-fatality rate among hospitalized DKA and HHS patients in a teaching hospital in Taiwan from 1991 to 2005...
  70. ncbi [Efficacy of total removal or subtotal removal combined gamma knife radiation on giant pituitary adenoma: a report of 160 cases]
    Qi Hua Xiao
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P R China
    Ai Zheng 26:742-7. 2007
    ..However, the outcome, especially for giant pituitary adenoma, is not very satisfactory. This study was to explore the efficacy of total tumor removal or subtotal tumor removal combined gamma knife radiation on giant pituitary adenoma...
  71. ncbi [An elderly case of hyperglycemic hyperosmolar non-ketotic coma (HHNC)]
    Akio Kawakami
    Geriatrics and Vascular Medicine, Tokyo Medical and Dental University
    Nihon Ronen Igakkai Zasshi 44:756-60. 2007
    ..It is thought that a number of elderly diabetic patients who need insulin therapy do not receive or continue it for various reasons. Discussion is necessary to grasp the actual situation and defensive actions that can be taken...
  72. ncbi Ventricular septal rupture presenting with hyperosmolar hyperglycemic nonketotic coma
    Ersan Tatli
    Department of Cardiology, School of Medicine, Trakya University, Edirne, Turkey
    Saudi Med J 28:972-3. 2007
  73. ncbi [Hyperglycemic acute crisis in type 1 diabetes mellitus in youth]
    Durval Damiani
    Instituto da Criança, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Endocrinol Metabol 52:367-74. 2008
    ..DKA is still a high-mortality condition. And to be in a hurry frequently leads to neurologic sequelae and even to a fatal outcome...
  74. ncbi Diabetes mellitus and periodontal disease
    Brian L Mealey
    Department of Periodontics, University of Texas Health Sciences Center at San Antonio, USA
    Periodontol 2000 44:127-53. 2007
  75. ncbi Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature
    N Ahuja
    Wallsend Community Mental Health Team, Sir GB Hunter Hospital, Wallsend, Tyne and Wear, UK
    J Psychopharmacol 24:125-30. 2010
    ..These questions are considered in the context of currently available literature...
  76. ncbi Methods for the quantitative assessment of electrolyte disturbances in hyperglycaemia
    E Bartoli
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    Nutr Metab Cardiovasc Dis 19:67-74. 2009
    ..When Posm(1)=Posm(0), GA must equal the loss of ions induced by the osmotic diuresis (2 x DeltaNa), and the math solution is exact. We herein report data validating these new computational methods...
  77. ncbi Type 2 diabetes in children and adolescents
    Chayim Y Newmark
    Saint Barnabas Medical Center Ambulatory Care Center, Livingston, New Jersey 07039, USA
    Pediatr Ann 36:109-13. 2007
  78. ncbi Hyperosmolar coma due to exclusive glucose accumulation: recognition and computations
    Ettore Bartoli
    Internal Medicine, Department of Clinical and Experimental Medicine, Eastern Piedmont University, Novara, Italy
    Nephrology (Carlton) 14:338-44. 2009
    ....
  79. ncbi Hyperglycemic crises and their complications in children
    Arlan L Rosenbloom
    Division of Endocrinology, Department of Pediatrics, University of Florida College of Medicine, Children s Medical Services Center, 1701 SW 16th Avenue, Gainesville 32608, USA
    J Pediatr Endocrinol Metab 20:5-18. 2007
    ..The prevention of DKA and HHS at the onset of diabetes mellitus requires a high degree of awareness and suspicion by primary care providers; prevention of recurrent DKA necessitates a diligent team effort...
  80. pmc Extensive venous thrombosis of the upper extremity in a diabetic patient with a hyperosmolar hyperglycemic state
    Juri Park
    Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Korean J Intern Med 21:244-7. 2006
    ..Therefore, our patient was treated with early catheter-directed thrombolysis followed by anticoagulation...
  81. ncbi Diabetic emergencies in small animals
    Mauria A O'Brien
    Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, 1008 West Hazelwood Drive, Urbana, IL 61802, USA
    Vet Clin North Am Small Anim Pract 40:317-33. 2010
    ..This article reviews the biochemical alterations contributing to these conditions, and discusses traditional and controversial management strategies...
  82. ncbi Case of the month. The details prevail
    Paul A Werfel
    University Medical Center, State University of New York, USA
    JEMS 31:36. 2006
  83. ncbi Tap-induced blink reflex and central nervous system dysfunction in diabetics with hyperosmolality
    Y Tachibana
    Department of Internal Medicine, Mejiro 2nd Hospital, Tokyo, Japan
    Eur Neurol 30:145-8. 1990
    ..In some patients with similar elevations in serum osmolality the R2' component was absent at a time when consciousness was preserved. Hence, TBR may be useful in monitoring CNS dysfunction in diabetics with hyperosmolality...
  84. ncbi Acute complications
    M Cypress
    Lovelace Health Systems, Albuquerque, USA
    RN 64:26-31; quiz 32. 2001
    ..You'll need to be able to quickly identify and know how to manage the acute complications of diabetes to help a patient avoid a tragic outcome. Here's how...
  85. ncbi [Proper help can save lives. Often symptoms are misinterpreted, nonetheless every second counts for the diabetic patient]
    Mario Hohenegger
    Pflege Aktuell 56:413-5. 2002
  86. ncbi [Acute complications due to diabetes mellitus: Hyperosmolar nonketotic coma]
    Koichi Kawanishi
    Kagawa Prefectural College of Health Sciences
    Nihon Rinsho 60:124-8. 2002
  87. ncbi Hyperosmolarity and acidosis in diabetes mellitus: a three-year experience in Rhode Island
    T J Wachtel
    Rhode Island Hospital, Providence 02903
    J Gen Intern Med 6:495-502. 1991
    ....
  88. ncbi Hyperglycaemic hyperosmolar syndrome in young obese Afro-Caribbean adults--a diagnostic dilemma. Report of two cases
    T M Ibrahim
    West Indian Med J 52:259. 2003
  89. ncbi [Diabetic coma. Management of diabetic ketoacidosis and nonketotic hyperosmolar coma]
    J Hensen
    Medizinische Klinik, Klinikum Hannover Nordstadt
    Internist (Berl) 44:1260-74. 2003
    ..With today's therapeutic possibilities the therapeutic goal, i.e. a low mortality, may be achieved, dependent on the underlying illness...
  90. ncbi [Treatment of acute metabolic crisis in diabetes mellitus]
    Gyorgy Jermendy
    Bajcsy Zsilinszky Kórház, III Belgyógyászati Osztály, Budapest
    Orv Hetil 145:81-3. 2004
  91. ncbi Hyperosmolar non-ketotic diabetic syndrome associated with rhabdomyolysis and acute renal failure: a case report and review of literature
    T Ka
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Diabetes Nutr Metab 16:317-22. 2003
    ..This rare case is presented along with a review of literature...
  92. ncbi Hyperglycemic crises in diabetes mellitus type 2
    D L Trence
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Endocrinol Metab Clin North Am 30:817-31. 2001
    ..Medications such as the protease inhibitors may in the future lead to a better understanding of the pathophysiology of the metabolic derangements seen in the development of type 2 diabetes mellitus...
  93. ncbi Acute postoperative metabolic complications of diabetes
    D Grimaud
    Département d Anesthésie Réanimation Est Hôpital Saint Roch, Nice, France
    Minerva Anestesiol 67:263-70. 2001
    ..as it would in an non diabetic patient. Lactic acidosis due to a treatment with metformin is now very rare and occurs almost only in patients having a contraindication to the use of metformin...
  94. ncbi [Diabetic emergencies]
    W Berger
    Abteilung Endokrinologie, Kantonsspital Basel
    Praxis (Bern 1994) 86:308-13. 1997
    ..When the renal function is impaired, biguanide treatment is not indicated because of the risk of lactic acidosis. Most of the diabetic emergency situations are avoidable by proper education of the patients...
  95. ncbi Significance of increased serum elastase 1 level during the hyperosmolar hyperglycemic non-ketotic syndrome
    S Umeki
    Department of Medicine, Kawasaki Medical School, Okayama, Japan
    Hepatogastroenterology 34:212-4. 1987
    ..Rehydration therapy with half-normal saline solution immediately produced negative urine glucose, but the serum elastase 1 level only gradually normalized after improvement of HHNS...
  96. ncbi Treatment of hyperglycaemic hyperosmolar non-ketotic syndrome
    S N Levine
    Department of Medicine, Louisiana State University Medical Center, Shreveport
    Drugs 38:462-72. 1989
    ..This review discusses the current state of knowledge concerning the pathogenesis of HHNS, the clinical features of the disorder, and a systematic approach to treatment...
  97. ncbi Lateral pontine and extrapontine myelinolysis associated with hypernatremia and hyperglycemia
    R D McComb
    Department of Pathology, University of Nebraska Medical Center, Omaha 68105
    Clin Neuropathol 8:284-8. 1989
    ..In both hypo- and hypernatremic states, the significant event may be an increase in serum sodium or serum osmolality of sufficient rapidity and magnitude...
  98. ncbi Diabetic hyperosmolar non-ketotic decompensation
    M Small
    University Department of Medicine, Royal Infirmary, Glasgow
    Q J Med 66:251-7. 1988
    ....
  99. ncbi Fluid and electrolyte disorders associated with diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic coma
    D E Butts
    Mount Carmel Medical Center, Columbus, Ohio
    Nurs Clin North Am 22:827-36. 1987
    ..Assessment of the patient's knowledge about diabetes is essential so that proper education can be incorporated into his or her plan of care...
  100. ncbi Diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma
    A E Kitabchi
    Division of Endocrinology and Metabolism, University of Tennessee, Memphis
    Med Clin North Am 72:1545-63. 1988
    ..The physiology of the fed and fasted state, evaluation, therapeutic issues, recommendations for therapy, immediate follow up care, and complications of therapy are reviewed for both syndromes...
  101. ncbi Hyperosmolar nonketotic diabetic coma: diagnosis and management
    J T Braaten
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Geriatrics 42:83-8, 92. 1987
    ..Complications of therapy can be congestive heart failure secondary to excessive fluid administration, hypoglycemia if too much insulin is given, and hypokalemia if potassium is inadequately replaced...