endocrine system diseases

Summary

Summary: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.

Top Publications

  1. ncbi Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery
    Alexandra I Stavrakis
    Endocrine Surgical Unit and Center for Surgical Outcomes and Quality, VA Greater Los Angeles Healthcare System, Los Angeles, Calif, USA
    Surgery 142:887-99; discussion 887-99. 2007
  2. ncbi Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7152-60. 2005
  3. ncbi Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities
    Eugenia Resmini
    Department of Endocrinology and Medical Sciences, Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy
    Acta Diabetol 46:85-95. 2009
  4. ncbi Investigation of new co-factors in 49 patients with pyoderma gangrenosum
    Philipp Al Ghazal
    Clinic and Polyclinic for Dermatology, Venereology, and Allergology, Essen University Hospital, Hufelandstrasse 55, Essen, Germany
    J Dtsch Dermatol Ges 10:251-7. 2012
  5. ncbi Prevalence of symptomatic androgen deficiency in men
    Andre B Araujo
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 92:4241-7. 2007
  6. ncbi Who performs endocrine operations in the United States?
    Brian D Saunders
    Department of Surgery, Divisions of Endocrine Surgery and Vascular Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 2920H, Ann Arbor, MI 48109 0331, USA
    Surgery 134:924-31; discussion 931. 2003
  7. pmc McCune-Albright syndrome
    Claudia E Dumitrescu
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Orphanet J Rare Dis 3:12. 2008
  8. ncbi Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach
    Elisabeth F C van Rossum
    University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 20:611-26. 2006
  9. ncbi Endocrine disorders in two sisters affected by MELAS syndrome
    P Balestri
    Department of Pediatrics, University of Siena, Italy
    J Child Neurol 15:755-8. 2000
  10. ncbi Radical resection of craniopharyngioma
    Graciela Zuccaro
    Department of Neurosurgery, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Childs Nerv Syst 21:679-90. 2005

Detail Information

Publications234 found, 100 shown here

  1. ncbi Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery
    Alexandra I Stavrakis
    Endocrine Surgical Unit and Center for Surgical Outcomes and Quality, VA Greater Los Angeles Healthcare System, Los Angeles, Calif, USA
    Surgery 142:887-99; discussion 887-99. 2007
    ..We examined the effect of surgeon volume on clinical and economic outcomes for thyroid, parathyroid, and adrenal surgery across inpatient and outpatient settings...
  2. ncbi Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7152-60. 2005
    ....
  3. ncbi Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities
    Eugenia Resmini
    Department of Endocrinology and Medical Sciences, Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy
    Acta Diabetol 46:85-95. 2009
    ..Indeed, it has been demonstrated that insulin glargine, given once daily, reduces the risk of hypoglycaemia compared with other formulations, and can facilitate a more aggressive insulin treatment in this class of patients...
  4. ncbi Investigation of new co-factors in 49 patients with pyoderma gangrenosum
    Philipp Al Ghazal
    Clinic and Polyclinic for Dermatology, Venereology, and Allergology, Essen University Hospital, Hufelandstrasse 55, Essen, Germany
    J Dtsch Dermatol Ges 10:251-7. 2012
    ..According to current textbooks, it is often associated with chronic inflammatory bowel diseases or other autoimmune disorders...
  5. ncbi Prevalence of symptomatic androgen deficiency in men
    Andre B Araujo
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 92:4241-7. 2007
    ..Despite recognition that androgen deficiency in men should be defined according to biochemical and clinical criteria, most prevalence estimates are based on low testosterone levels alone...
  6. ncbi Who performs endocrine operations in the United States?
    Brian D Saunders
    Department of Surgery, Divisions of Endocrine Surgery and Vascular Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 2920H, Ann Arbor, MI 48109 0331, USA
    Surgery 134:924-31; discussion 931. 2003
    ..Endocrine surgery is a discipline that is dedicated to high-quality care of patients with endocrine surgical disease. The relationship between its "identity" as a separate field and clinical practice patterns is not known...
  7. pmc McCune-Albright syndrome
    Claudia E Dumitrescu
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Orphanet J Rare Dis 3:12. 2008
    ..Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS...
  8. ncbi Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach
    Elisabeth F C van Rossum
    University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 20:611-26. 2006
    ..Diagnosis of generalized GC resistance can be difficult. This review highlights the diagnostic process and therapeutic options for treating patients with this disease...
  9. ncbi Endocrine disorders in two sisters affected by MELAS syndrome
    P Balestri
    Department of Pediatrics, University of Siena, Italy
    J Child Neurol 15:755-8. 2000
    ....
  10. ncbi Radical resection of craniopharyngioma
    Graciela Zuccaro
    Department of Neurosurgery, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Childs Nerv Syst 21:679-90. 2005
    ..Trying to remove a craniopharyngioma that has been treated previously with other methods is, in our experience, much more dangerous because of adherences of the tumor to vascular and neural structures...
  11. ncbi The maturation of a specialty: Workforce projections for endocrine surgery
    Julie Ann Sosa
    Section of Endocrine Surgery, Department of Surgery, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Conn, USA
    Surgery 142:876-83. 2007
    ..Fellowship programs will lead to more specialty-trained endocrine surgeons. We make projections for the supply of endocrine surgeons and demand for endocrine procedures over the next 15 years...
  12. ncbi Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma
    Indro Chakrabarti
    Department of Neurological Surgery, University of Southern California, Los Angeles, California 90032, USA
    J Neurosurg 102:650-7. 2005
    ..More specifically, they evaluate the role of the TN approach in the management of craniopharyngioma...
  13. ncbi Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome
    M Caldarelli
    Section of Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Rome, Italy
    Childs Nerv Syst 21:747-57. 2005
    ..In order to avoid such complications, some authors have suggested to renounce to radical resection and to rely on post-operative radiation therapy to minimise the risk of residual tumour progression...
  14. ncbi Craniopharyngioma in children: Marseille experience
    Gabriel Lena
    Department of Pediatric Neurosurgery, hôpital des Enfants La Timone, 264, rue Saint Pierre, 13385, Marseille, Cedex 05, France
    Childs Nerv Syst 21:778-84. 2005
    ....
  15. ncbi Endocrine complications of hematopoietic stem cell transplantation
    Wassim Chemaitilly
    Department of Pediatrics, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, NY 11040, USA
    Endocrinol Metab Clin North Am 36:983-98; ix. 2007
    ..This article focuses on the late endocrine abnormalities that are most commonly observed following successful HSCT, with a special emphasis on pediatric HSCT recipients, for whom long-term follow-up data are increasingly available...
  16. ncbi Secondary causes of osteoporosis
    Lorraine A Fitzpatrick
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, and Internal Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 77:453-68. 2002
    ..This article provides the framework for understanding causes of bone loss and approaches to their management...
  17. ncbi Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology
    Bruno Ferraz de-Souza
    UCL Institute of Child Health and Department of Medicine, University College London, UK
    Pediatr Endocrinol Rev 3:359-64. 2006
    ....
  18. ncbi Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  19. pmc A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems
    Piya Lahiry
    Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Am J Hum Genet 84:134-47. 2009
    ..We also demonstrate that the R272Q mutant fails to localize at the nucleus and has diminished kinase activity. These findings suggest that ICK plays a key role in the development of multiple organ systems...
  20. ncbi Image diagnosis in McCune-Albright syndrome
    Claudio Defilippi
    Radiology Department, Regina Margherita Children s Hospital, Turin, Italy
    J Pediatr Endocrinol Metab 19:561-70. 2006
    ..Bone scintigraphy with technetium 99 is essential in the follow-up of the disease. Ultrasonography is very useful in ovarian cyst follow-up and in the detection of thyroid and adrenal nodules and testicular microlithiasis...
  21. ncbi Minireview: PRKAR1A: normal and abnormal functions
    Ioannis Bossis
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Endocrinology 145:5452-8. 2004
    ....
  22. ncbi McCune-Albright syndrome and disorders due to activating mutations of GNAS1
    Alejandro Diaz
    Division of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, NY, USA
    J Pediatr Endocrinol Metab 20:853-80. 2007
    ..We discuss here the clinical consequences of GNAS1 activating mutations in different body systems and organs, the diagnostic approach to MAS, and the current therapeutic recommendations...
  23. ncbi Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence
    S Shalitin
    Institute for Endocrinology and Diabetes, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 49202, Israel
    Bone Marrow Transplant 37:1109-17. 2006
    ..9% of the 43 patients tested. These findings emphasize the need for long-term follow-up of endocrine and metabolic parameters in young patients after BMT in order to offer proper treatment and improve quality of life...
  24. ncbi Late endocrine, metabolic and skeletal sequelae following treatment of childhood cancer
    Helena K Gleeson
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester, Withington, M20 4BX, UK
    Best Pract Res Clin Endocrinol Metab 16:335-48. 2002
    ..In this review we consider the following potential problems: growth hormone deficiency and replacement in adulthood, cardiovascular risk factors, osteopaenia, thyroid and parathyroid dysfunction...
  25. ncbi Endocrine abnormalities in patients with Fanconi anemia
    Neelam Giri
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard EPS 7024, Rockville, Maryland 20852, USA
    J Clin Endocrinol Metab 92:2624-31. 2007
    ..Fanconi anemia (FA) is an inherited disorder with chromosomal instability, bone marrow failure, developmental defects, and a predisposition to cancer. Systematic and comprehensive endocrine function data in FA are limited...
  26. ncbi Endocrine late effects from multi-modality treatment of neuroblastoma
    H M van Santen
    Department of Paediatric Endocrinology, Emma Children s Hospital AMC, G8 205, Academic Medical Center AMC, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur J Cancer 41:1767-74. 2005
    ..We recommend that during follow-up of neuroblastoma children, special attention should be paid to their endocrine state...
  27. ncbi Endocrine sequelae of cancer therapy in childhood
    F B Diamond
    Department of Pediatrics University of South Florida College of Medicine, Tampa, USA
    J Endocrinol Invest 24:648-58. 2001
    ..These include effects on growth, puberty, fertility, thyroid and adrenal function which may present many years after the successful treatment of underlying disease...
  28. ncbi Admission and discharge guidelines for the pediatric patient requiring intermediate care
    David G Jaimovich
    Hope Children s Hospital, Oak Lawn, IL, USA
    Crit Care Med 32:1215-8. 2004
    ..This level of care may enhance the efficiency of care and improve the healthcare affordability for patients receiving intermediate care...
  29. ncbi The late effects of childhood cancer therapy
    Joseph D Dickerman
    University of Vermont College of Medicine, Department of Pediatrics, 89 Beaumont Ave, Given D201, Burlington, VT 05405 0068, USA
    Pediatrics 119:554-68. 2007
    ..A table listing radiation-therapy site and chemotherapeutic agents and selected late effects that result from their use is provided. Finally, a brief recommendation regarding the establishment of a late-effects clinic is also presented...
  30. ncbi [Etiology and blood pressure patterns in secondary hypertension in children]
    Cristina Gavrilovici
    Clinica a IV a Pediatrie, Facultatea de Medicina, Universitatea de Medicină şi Farmacie Gr T Popa, Iasi
    Rev Med Chir Soc Med Nat Iasi 111:70-81. 2007
    ..10%), with a probability of identifying an underlying disease inversely related with the age and directly related with the severity of hypertension...
  31. ncbi Opiate drug use: a potential contributor to the endocrine and metabolic complications in human immunodeficiency virus disease
    Odelia B Cooper
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 37:S132-6. 2003
    ..Although much of the evidence should be viewed as preliminary, these potential abnormalities should be kept in mind when treating opiate-dependent patients infected with HIV...
  32. ncbi Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF)
    Vincenzo De Sanctis
    Department of Reproduction and Growth, Pediatric and Adolescent Unit, Arcispedale S Anna, Ferrara, Italy
    Pediatr Endocrinol Rev 2:249-55. 2004
    ..In conclusion, since iron overload and liver damage seem to be the most important factors responsible for endocrine complications, adequate compliance to chelation therapy and rigid precautions against liver infections are imperative...
  33. ncbi [Severe chronic anemia and endocrine disorders in children]
    Michael Hauschild
    Unité d endocrinologie diabétologie pédiatrique, Département médico chirurgical de pédiatrie, CHUV, 1011 Lausanne
    Rev Med Suisse 3:988-91. 2007
    ..Diabetes mellitus, hypothyroidism and hypoparathyroidism may also develop. Follow-up includes close monitoring of growth and pubertal development in order to guide therapeutic interventions...
  34. ncbi The pre-operative endocrine assessment of craniopharyngiomas
    Neil Hopper
    Department of Paediatric Endocrinology, St George s Hospital, London, UK
    J Pediatr Endocrinol Metab 19:325-7. 2006
    ..We review the available published data on pre-operative endocrine dysfunction and suggest an approach to assessment and management before surgery...
  35. ncbi Endocrine gland abnormalities in thalassemia major: a brief review
    Sakineh Mohammadian
    Department of Pediatrics, Golestan University of Medical Sciences, Gorgan, Iran
    J Pediatr Endocrinol Metab 16:957-64. 2003
    ..In this article we briefly review the current understanding of endocrine gland abnormalities, primarily caused by iron overload, in patients with thalassemia major...
  36. ncbi Low bone mineral density in adolescents with beta-thalassemia
    Maria G Vogiatzi
    Department of Pediatrics, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Ann N Y Acad Sci 1054:462-6. 2005
    ..Thus, calcium and vitamin D supplementation with antiresorptive therapies should be evaluated in the adolescent Thal pt with close monitoring of growth and sexual development...
  37. ncbi Comparison of oral and subcutaneous iron chelation therapies in the prevention of major endocrinopathies in beta-thalassemia major patients
    Chung Hsing Wang
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    Hemoglobin 30:257-62. 2006
    ....
  38. ncbi Endocrinological late effects following radiotherapy and chemotherapy of childhood brain tumours
    Marianne Schmiegelow
    Department of Endocrinology, Abdominal Centre, University Hospitality, H S Rigshospitalet, Copenhagen, Denmark
    Dan Med Bull 53:326-41. 2006
  39. ncbi Update on autoimmune polyendocrine syndromes (APS)
    Corrado Betterle
    Clinical Immunology and Allergology, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Acta Biomed 74:9-33. 2003
    ....
  40. ncbi [Werner's syndrome and endocrine disorders]
    B Zantour
    Service de Médecine Interne et Endocrinologie, CHU Tahar Sfar, Mahdia, Tunisie
    Ann Endocrinol (Paris) 64:205-9. 2003
    ..Thus, in Werner's syndrome metabolic and endocrinologic investigation is necessary in order to treat these disorders and improve the patient's prognosis and life...
  41. ncbi Clinical uses and misuses of dehydroepiandrosterone
    Emanuela Binello
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    Curr Opin Pharmacol 3:635-41. 2003
    ..Research is ongoing at both the basic and the clinical level to elucidate mechanisms of action and establish efficacy and safety, as well as to expand new areas of potential application for this multi-faceted hormone...
  42. ncbi Endocrine and metabolic manifestations of invasive fungal infections and systemic antifungal treatment
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mayo Clin Proc 83:1046-60. 2008
    ..If clinicians are equipped with better knowledge of the endocrine and metabolic complications of fungal infections and antifungal therapy, they can more readily recognize them and favorably affect outcome...
  43. ncbi Drug-induced endocrine and metabolic disorders
    Ronald C W Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Drug Saf 30:215-45. 2007
    ....
  44. ncbi Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 45:771-91. 2006
    ..Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications...
  45. ncbi Medical causes of headache in children
    Nicholas S Abend
    Department of Neurology, The University of Pennsylvania School of Medicine, and Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Pain Headache Rep 11:401-7. 2007
    ..Medical causes of headache are so diverse that uniform screening tests are not useful. History and examination must guide the differential diagnosis, and management plans must be individualized...
  46. ncbi Indications for synergetic and antagonistic effects between trace elements in the environment to human health
    Jasmina Obhodas
    Experimental Physics Department, Institute Ruder Boskovic, Zagreb, Croatia
    Coll Antropol 31:209-19. 2007
    ..The results reported here emphasize the importance of the observation of the mutual effects of the environmental variables on the human health for the identification of their synergetic as well as antagonistic effects...
  47. ncbi Recognition and treatment of endocrine/metabolic emergencies in children: part I
    Michael S Kappy
    University of Colorado Health Sciences Center, The Children s Hospital, Denver, USA
    Adv Pediatr 49:245-72. 2002
    ..Prompt diagnosis depends on the collection of critical and archival laboratory specimens before the administration of nonspecific therapy...
  48. ncbi Tremor in children
    Mohammad K Uddin
    Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Semin Pediatr Neurol 10:26-34. 2003
    ..This review covers the etiology, clinical features, and treatment of the major tremor syndromes in children, and when appropriate, makes comparisons with similar disorders in adults...
  49. ncbi Late health effects of childhood nasopharyngeal radium irradiation: nonmelanoma skin cancers, benign tumors, and hormonal disorders
    Cécile M Ronckers
    Department of Ear, Nose and Throat Medicine, Reinaert Kliniek, Maastricht, The Netherlands
    Pediatr Res 52:850-8. 2002
    ..0-2.1). We found no evidence of highly elevated risk of benign head and neck tumors, nonmelanoma skin cancer, thyroid disorders, or indicators of pituitary radiation damage after childhood NRI in The Netherlands...
  50. ncbi Pediatric thyroid testing issues
    Mark D DeBoer
    Department of Pediatrics, Division of Endocrinology, University of Virginia, VA, USA
    Pediatr Endocrinol Rev 5:570-7. 2007
    ..Additionally, heterophile and anti-T4 or anti-TSH antibodies can interfere with accurate T4 or TSH measurement...
  51. ncbi Impact of thalassemia major on patients and their families
    J Jaime Caro
    Caro Research Institute, Concord, MA 07142, USA
    Acta Haematol 107:150-7. 2002
    ..To describe the burden of thalassemia major and its treatment, in terms of prevalence of iron-overload-related complications, direct and indirect costs, and the patient's physical and social well-being...
  52. ncbi Endocrine manifestations of chromosome 22q11.2 microdeletion syndrome
    Jin Ho Choi
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Horm Res 63:294-9. 2005
    ..2 microdeletion syndrome. This study was undertaken to examine the frequencies and clinical features of endocrine abnormalities in patients with 22q11.2 microdeletion syndrome...
  53. ncbi [Adverse effects of psychotropic agents]
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine
    Nihon Rinsho 65:247-53. 2007
  54. ncbi Sleep apnea and sports performance
    Helene A Emsellem
    The Center for Sleep and Wake Disorders, 5454 Wisconsin Avenue, Suite 1725, Chevy Chase, MD 20815, USA
    Clin Sports Med 24:329-41, x. 2005
    ..A high index of suspicion for apnea should exist, particularly in those who have anatomic features and symptoms consistent with the disorder. This article reviews pathophysiology, diagnostic modalities, and treatment interventions...
  55. ncbi [New advances in drug therapy in 2003-2004]
    A J Scheen
    Universite de Liege, Service de Médecine interne générale et Service de Diabétologie, Nutrition et Maladies Metaboliques, Departement de Medecine
    Rev Med Liege 59:385-402. 2004
    ..Most of them are currently studied in order to further demonstrate their potential benefit on a long-term basis, in large cohort of patients and using hard clinical endpoints...
  56. ncbi Endocrine complications of neoplastic diseases in children and adolescents
    H K Gleeson
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Curr Opin Pediatr 13:346-51. 2001
    ....
  57. ncbi Drosophila melanogaster as a model system for drug discovery and pathway screening
    Sanjay Tickoo
    Department of Genetics, University of Cambridge, UK
    Curr Opin Pharmacol 2:555-60. 2002
    ....
  58. ncbi Endocrine and metabolic deficiency
    Gregory F Wu
    Department of Neurology, University of Pennsylvania School of Medicine, 3 E Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ophthalmol Clin North Am 17:427-34, vii. 2004
    ....
  59. ncbi [The numbers of patients with endocrine disorders are increasing. Who will be responsible for them in the future?]
    Mann Klaus
    Klinik fur Endokrinologie, Universitatsklinikum Essen
    MMW Fortschr Med 148:25-6. 2006
  60. ncbi Critical issues in endocrinology
    Philip A Goldberg
    Section of Endocrinology, Yale University School of Medicine, TMP 534, 333 Cedar Street, New Haven, CT 06520, USA
    Clin Chest Med 24:583-606, vi. 2003
    ..Other endocrine issues that are related to intensive care, such as intensive insulin therapy, relative adrenal insufficiency, and thyroid function test abnormalities are also covered in detail...
  61. ncbi A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Medicine (Baltimore) 86:215-24. 2007
    ..2%, and male hypogonadism 20.3%. Coexistence of multiple late sequelae was common in HSCT survivors. Our findings provide a basis for more effective patient counseling, optimal surveillance, and early intervention...
  62. ncbi [Hormone therapies in pregnancy]
    G A Tommaselli
    Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Universita Degli Studi Di Napoli, Federico II, Napoli, Italy
    Minerva Ginecol 54:145-50. 2002
    ..In this review, the incidence of the main endocrine disorders, their evolution during pregnancy, their effects on mothers and fetuses and new acquisition on the treatment during pregnancy are discussed...
  63. ncbi Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications
    N A Aziz
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Rev Neurosci 18:223-51. 2007
    ....
  64. ncbi Endothelial dysfunction in endocrine disease
    T A Abdu
    Dept of Medicine, School of Postgraduate Medicine, Keele University, Staffordshire, ST4 7QB, Keele, UK
    Trends Endocrinol Metab 12:257-65. 2001
    ....
  65. ncbi Endocrine and growth features in childhood craniopharyngioma: a mono-institutional study
    Eliana di Battista
    Auxoendocrinological Centre, Paediatric Department, University of Genoa, School of Medicine, Italy
    J Pediatr Endocrinol Metab 19:431-7. 2006
    ..To evaluate growth and endocrine features in children with craniopharyngioma who were treated and followed up by a single institution between 1976 and 2004...
  66. ncbi Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003
    Martin Benesch
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria
    J Neurooncol 78:199-205. 2006
    ..As long-term survival is excellent in patients with low-grade gliomas except for tumors located in the brainstem, future treatment studies should focus on avoiding long-term late effects...
  67. ncbi Nonmalignant late effects after allogeneic stem cell transplantation
    Gerard Socie
    Hematology Stem Cell Transplantation, Hopital Saint Louis, Paris, France
    Blood 101:3373-85. 2003
  68. ncbi Definable somatic disorders in overweight children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr 150:618-22, 622.e1-5. 2007
    ..To analyze the frequencies and clinical presentation of definable somatic disorders in children who are overweight...
  69. pmc Atypical psychotropic medications and their adverse effects: a review for the African-American primary care physician
    Rahn Kennedy Bailey
    University of Texas Medical School at Houston, USA
    J Natl Med Assoc 95:137-44. 2003
    ..A particular focus will address the increasing concern that these new medications can produce hyperglycemia and diabetes mellitus...
  70. ncbi Long-term endocrine effects of cancer treatment: experience of the Royal Children's Hospital, Melbourne
    R Hameed
    Department of Endocrinology and Diabetes, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 41:36-42. 2005
    ..To evaluate the frequency and degree of severity of endocrine late effects in patients treated for childhood cancer and to assess the value of the late effects clinic for continued monitoring of these patients...
  71. ncbi Posterior ocular malformations in children: somatic, neuroradiological and cognitive aspects
    K Tear Fahnehjelm
    Department of Clinical Science, Division of Paediatric Ophthalmology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Acta Paediatr 92:301-8. 2003
    ..To investigate associated neurological, endocrinological and cognitive dysfunctions in children with visual impairment caused by optic nerve hypoplasia or optic nerve/fundus coloboma and/or microphthalmus...
  72. ncbi Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence
    Leslie L Robison
    Division of Pediatric Epidemiology and Clinical Research, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Br J Haematol 122:345-59. 2003
  73. ncbi Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 97:663-73. 2003
    ....
  74. ncbi Pesticides and children
    Vincent F Garry
    Department of Laboratory Medicine and Pathology and Program in Toxicology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Toxicol Appl Pharmacol 198:152-63. 2004
    ..The level of consensus among these studies is examined. Current concerns regarding neurobehavioral toxicity and endocrine disruption in juxtaposition to the relative paucity of toxicant mechanism-based studies of children are explored...
  75. ncbi Sexual symptoms in endocrine diseases: psychosomatic perspectives
    Giancarlo Balercia
    Endocrinology, Andrology Unit, Department of Clinical Medicine and Applied Biotechnologies, Polytechnic University of Marche, Ancona, Italy
    Psychother Psychosom 76:134-40. 2007
    ..may have a greater or lesser effect on sexual function...
  76. ncbi Endocrine abnormalities in patients with frontoethmoidal encephalomeningocele. A preliminary study
    S Wacharasindhu
    Endocrine Unit, Department of Pediatrics, Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
    Horm Res 64:64-7. 2005
    ..Frontoethmoidal encephalomeningocele (FEEM) is a congenital neural tube defect which is more common in Southeast Asia. Its etiology is unknown. No one has ever reported endocrine abnormalities in this condition...
  77. ncbi Craniopharyngioma radiotherapy: endocrine and cognitive effects
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38104, USA
    J Pediatr Endocrinol Metab 19:439-46. 2006
    ..Early and accurate evaluation of these functions should be considered for all patients to provide parents and caregivers with the information necessary to plan intervention and mitigate the consequences of tumor and treatment...
  78. ncbi Gender differences in GAD antibody-positive diabetes mellitus in relation to age at onset, C-peptide and other endocrine autoimmune diseases
    Eero Lindholm
    Department of Endocrinology, University Hospital, Malmo, Sweden
    Diabetes Metab Res Rev 20:158-64. 2004
    ....
  79. ncbi The hepatitis C virus infection as a systemic disease
    Anna Linda Zignego
    Department of Internal Medicine, Center for Systemic Manifestations of Hepatitis Viruses MASVE, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    Intern Emerg Med 7:S201-8. 2012
    ..The possibility that HCV may be eradicated following antiviral therapy is important for both the therapeutic and preventive points of view, making the HCV disease an ideal model for pathogenetic studies...
  80. pmc β-thalassemia intermedia: a clinical perspective
    Khaled M Musallam
    Department of Medicine and Medical Specialties, IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, 20122 Milan, Italy
    Cold Spring Harb Perspect Med 2:a013482. 2012
    ..The effects of some therapeutic interventions on the development of clinical complications are also discussed...
  81. ncbi Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults
    M S García Gallo
    Endocrinology Division, Hospital Carlos G Durand, Av Díaz Vélez 5040, Buenos Aires, C1405DCR, Argentina
    Pituitary 13:298-303. 2010
    ..Three cases were treated with chemotherapy; one of them had already received radiation therapy on the hypothalamic-pituitary region, developing post-radiation hypopituitarism...
  82. ncbi Optimizing potential for fertility: fertility preservation considerations for the pediatric endocrinologist
    Peter A Lee
    Department of Pediatrics, Penn State College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Endocrinol Metab Clin North Am 38:761-75. 2009
    ..For adolescent subjects who have sufficient gonadal development and reserve, sperm, oocytes, and ovarian cortex can be retrieved as among adults...
  83. ncbi Dynamic tests in the diagnosis and differential diagnosis of Cushing's syndrome
    D G Morris
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    J Endocrinol Invest 26:64-73. 2003
    ....
  84. ncbi Conservative treatment of chronic pancreatitis
    Asif Khalid
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Eur J Gastroenterol Hepatol 14:943-9. 2002
    ..The good news is that the understanding of the underlying pathophysiological mechanisms is now advancing rapidly, and hopefully patient-specific and highly effective therapies will become available in the near future...
  85. ncbi Antipsychotics in children and adolescents: increasing use, evidence for efficacy and safety concerns
    Benedetto Vitiello
    National Institute of Mental Health, Room 7147, 6001 Executive Blvd, Bethesda, MD 20892 9633, USA
    Eur Neuropsychopharmacol 19:629-35. 2009
    ..Research is also needed to understand the mechanisms underlying antipsychotic-induced toxicities in order to develop effective preventive and treatment strategies...
  86. ncbi [Endocrine disorders and the heart]
    Onno E Janssen
    Klinik fur Endokrinologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Deutschland
    Internist (Berl) 48:246-54. 2007
    ..The same holds true for long-standing hyperparathyroidism. Recent prospective studies did not confirm the protective effect of hormone replacement therapy on cardiovascular disease...
  87. ncbi Hypothalamic obesity: prevalence, associations and longitudinal trends in weight in a specialist adult neuroendocrine clinic
    Caroline A Steele
    Department of Obesity and Endocrinology, University of Liverpool, Liverpool, UK
    Eur J Endocrinol 168:501-7. 2013
    ....
  88. pmc From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics
    Robert H J Bandsma
    Divisions of Gastroenterology, Hepatology and Nutrition Pathology Endocrinology, The Hospital for Sick Children Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON Alberta Children s Hospital Intestinal Rehabilitation Program, Alberta Children s Hospital and University of Calgary, Calgary, AB, Canada Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine at the University of California, Los Angeles, CA
    J Clin Gastroenterol 47:834-43. 2013
    ..The aim of this report is to delineate the clinical, pathologic, and enteroendocrine (EE) features of prohormone convertase 1/3 (PC1/3) deficiency in children...
  89. ncbi An endocrinopathy characterized by dysfunction of the pituitary-adrenal axis and alopecia universalis: supporting the entity of a triple H syndrome
    K Ichiki
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Eur J Endocrinol 147:357-61. 2002
    ..The present finding strongly supports a clinical entity of triple H syndrome, including ACTH deficiency, alopecia universalis and anterograde amnesia, and that there may be some variation of the triad among the subjects...
  90. ncbi Candida and human disease
    A G Palma-Carlos
    C A I C Clinical Allergy and Immunology Center
    Eur Ann Allergy Clin Immunol 36:291-6. 2004
    ..A general review on candida and human disease emphasizing Candida Species, clinical manifestations, immune response NK failure and immunotherapy...
  91. ncbi [Vasoactive polypeptides and cardiovascular endocrine diseases]
    Zheng pei Zeng
    Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:443-5. 2005
    ..New advances have been increasingly achieved in basic and clinical researches. It has become one of the most active areas in life sciences...
  92. ncbi [Genetic testing and gene-based testing for endocrine disorders]
    Toshihiko Yanase
    Department of Medicine and Bioregulatory Science Third Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 63:207-11. 2005
  93. ncbi Late effects of treatment in survivors of childhood acute myeloid leukemia
    W Leung
    After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 18:3273-9. 2000
    ..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)...
  94. pmc Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes
    Marguerite C Camp
    Laboratory of Behavioral and Genomic Neuroscience, NIAAA, Bethesda, MD, USA
    Neuropsychopharmacology 37:1534-47. 2012
    ..Collectively, these data provide convergent support for the utility of the S1 strain as a tractable model for elucidating the neural, molecular and genetic basis of persistent, excessive fear...
  95. ncbi Growth, final height and endocrine sequelae in a UK population of patients with Hurler syndrome (MPS1H)
    Chris J Gardner
    Royal Manchester Children s Hospital, Manchester, UK
    J Inherit Metab Dis 34:489-97. 2011
    ..Regular screening for the development of endocrine sequelae is therefore essential. We present for the first time data on final adult height and endocrine complications in children with MPSIH post HSCT...
  96. ncbi Hyperestrogenemia simulating kennedy disease
    Jin Jun Luo
    Departments of Neurology and Pharmacology, Temple University School of Medicine, Philadelphia, PA
    J Clin Neuromuscul Dis 9:291-6. 2007
    ..Splenomegaly was present by ultrasound. The increased level of estrogen adversely affected estrogen-sensitive cells in breast, testicular, neuronal, and muscle cells, leading to the clinical phenotype...
  97. ncbi [Structural CNS abnormalities responsible for coincidental occurrence of endocrine disorders, epilepsy and psychoneurologic disorders in children and adolescents]
    Jerzy Starzyk
    Klinika Endokrynologii Dzieci i Młodziezy, Katedra Pediatrii, Polsko Amerykanski Instytut Pediatrii, Uniwersytet Jagielloński Collegium Medicum, Krakow
    Przegl Lek 67:1120-6. 2010
    ..However, structural central nervous system (CNS) abnormalities that cause both endocrine and neurologic disorders seem to be markedly less common. No reports addressing this problem are available in the literature...
  98. ncbi Endocrine alterations around the time of abortion in mares impregnated with donkey or horse semen
    M Boeta
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Mexico, DF
    Anim Reprod Sci 121:124-30. 2010
    ..Deficiency of eCG may be a primary cause of many of these cases, either by failing to stimulate enough luteal progesterone secretion and/or by failing to protect the corpora lutea (CL) of pregnancy from endogenous PGF2alpha secretion...
  99. ncbi Endocrine function in multiple sclerosis
    P Klapps
    Neurology Clinic, Steglitz Clinic, Free University of Berlin, Germany
    Acta Neurol Scand 85:353-7. 1992
    ..However, the poststimulatory secretion of cortisol, growth hormone or thyroid-stimulating hormone was impaired in 7/31 patients, suggesting a possible preclinical endocrine insufficiency in these patients...
  100. ncbi Endocrine hypertension--current understanding and comprehensive management review
    Norlela Sukor
    Endocrine Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia
    Eur J Intern Med 22:433-40. 2011
    ....
  101. ncbi Endocrine disorders associated with inappropriately high aromatase expression
    S E Bulun
    Cecil H and Ida Green Center for Reproductive Biology Sciences and Department of Obstetrics Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9051, U S A
    J Steroid Biochem Mol Biol 61:133-9. 1997
    ..3 and II in all of the above tissues. This article describes the common pathophysiological and molecular features of excessive aromatase expression in these disease states...

Research Grants62

  1. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010
    ....
  2. Androgen deficiency and Osteopenia in Anorexia Nervosa
    Karen Miller; Fiscal Year: 2002
    ..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
  3. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2006
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  4. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2009
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  5. Population-Based Reference Ranges for Testosterone
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  6. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  7. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  8. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007
    ..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  9. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  10. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  11. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  12. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2002
    ....
  13. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..abstract_text> ..
  14. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  15. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  16. PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCER
    Charles Sklar; Fiscal Year: 2002
    ..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
  17. MN REGIONAL SLEEP DISORDERS CENTER SLEEP ACADEMIC AWARD
    Gerald Rosen; Fiscal Year: 2002
    ....
  18. PROSTATIC STEROIDS AND SECOND MESSENGERS
    William Rosner; Fiscal Year: 2001
    ....
  19. Cell Fate Determination of the Intestine and Chronic Diarrhea in Children
    Martin Martin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  21. Human Subjects Research Enhancements Programs
    William Rosner; Fiscal Year: 2002
    ..All such monthly reviews and quizzes will be archived for review. All of the above activities will be designed to be continued after the completion of the initial year of support. ..
  22. Regulation of Intestinal Nutrient Transporters
    Martin Martin; Fiscal Year: 2002
    ..The identification and further characterization of these cis elements will provide better insight into the molecular mechanism of enterocyte-specific cell fate and the various factors mediating its regulation. ..
  23. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  24. D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
    Eric Storch; Fiscal Year: 2007
    ..Such agents may have utility in improving outcome, reducing premature therapy termination, and targeting patients who have been treatment refractory. [unreadable] [unreadable] [unreadable]..
  25. PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSY
    Andrew Herzog; Fiscal Year: 2008
    ..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
  26. Epidemiology of Cancer and Mental Illness in Rural Areas
    Caroline Carney Doebbeling; Fiscal Year: 2005
    ..abstract_text> ..
  27. Neuroendocrine outcomes of prenatal PCB exposures
    ANDREA GORE; Fiscal Year: 2005
    ..The results should have important implications for understanding consequences of, and developing therapies for, exposures of wildlife and humans to EDCs such as PCBs. ..
  28. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT
    Russell Joffe; Fiscal Year: 2004
    ..No funds are sought for basic science research laboratories or any clinical areas in the Cancer Center. ..
  29. Evaluation of Vitamin D Requirements During Pregnancy
    Bruce Hollis; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  30. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2010
    ..Increased oxygenation should make tumors more sensitive to radiation;therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
  31. Fetal Programming of Early Development
    CURT ALAN SANDMAN; Fiscal Year: 2010
    ..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..
  32. Establishing the Vitamin D Requirements During Lactation
    Bruce W Hollis; Fiscal Year: 2010
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
  33. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  34. FANCONI ANEMIA--HETEROGENEITY AND CARRIER DETECTION
    ARLEEN AUERBACH; Fiscal Year: 2007
    ..This will be combined with functional complementation[unreadable] in an effort to accelerate the identification of these genes.[unreadable] [unreadable]..
  35. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  36. STRESS AND BIRTH OUTCOMES
    Curt Sandman; Fiscal Year: 2001
    ..The study design and analytic methods allows for estimation of the unique effects of CRH and psychosocial stress on the length of gestation. ..
  37. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  38. HEPATITIS C IN CHILDHOOD CANCER SURVIVORS
    Melissa Hudson; Fiscal Year: 2003
    ..abstract_text> ..
  39. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  40. Endocrine Function and Mood in Bipolar Disorder
    Natalie Rasgon; Fiscal Year: 2008
    ..abstract_text> ..
  41. CTL2 ELISA: A Diagnostic Test for Autoimmune Hearing Loss
    Vijay Kumar; Fiscal Year: 2007
    ..Current diagnostic methods are inadequate to support proper diagnosis AHL; our team proposes to develop a simple, yet precise test to meet this need. [unreadable] [unreadable] [unreadable]..
  42. CLINICAL SEARCH RETRIEVAL FROM FOUR ELECTRONIC DATABASES
    R Haynes; Fiscal Year: 2007
    ..g., sensitivity); and evaluating the usefulness of the clinical hedges in the intended users group, clinicians. [unreadable] [unreadable]..
  43. NEUROBIOLOGIC STUDIES OF THE LIMBIC SYSTEM IN AUTISM
    Margaret Bauman; Fiscal Year: 2004
    ..Further, studies for evidence of a progressive process, and involvement of selected neurotransmitter systems in the limbic system that have been implicated in the clinical features of autism will be conducted. ..
  44. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
  45. Role of the Zic2 gene in CNS development & malformation
    Stephen Brown; Fiscal Year: 2005
    ..In addition, our studies will elucidate the cellular and molecular processes that result in HPE and will therefore be useful in understanding this and other brain malformations. ..
  46. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..7. ..
  47. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  48. Emergence of SIB in Developmentally Delayed Individuals
    CURT ALAN SANDMAN; Fiscal Year: 2010
    ..Findings from this project will contribute to the understanding of the emergence and maintenance of SIB. ..
  49. REGIONAL BIOCONTAINMENT LABORATORY (RBL) NEWARK CENTER
    Russell Joffe; Fiscal Year: 2005
    ..When the RBL is operational, it will create a critical mass of biodefense scientists in Newark and serve as a specialized laboratory for emerging regional and national biodefense needs. ..
  50. Blockade of Anthrax Cytotoxicity Using Furin Inhibitors
    Iris Lindberg; Fiscal Year: 2003
    ..abstract_text> ..
  51. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  52. Winter Neuropeptides Conference
    Curt Sandman; Fiscal Year: 2004
    ..The conference is inclusive for all groups. Half of the organizing and steering committees are women. Efforts are made to include minorities and persons with disabilities. ..
  53. OPIOID PEPTIDE PROCESSING ENZYMES
    Iris Lindberg; Fiscal Year: 2002
    ..Taken together, these experiments should help us to understand the basic biochemistry of the prohormone convertases on opioid peptide precursors as well as the regulation of convertase activity. ..
  54. ERT, DEPRESSION AND COGNITION IN POSTMENOPAUSAL WOMEN
    Natalie Rasgon; Fiscal Year: 2002
    ..antidepressant alone. This research will be the foundation for a future investigation of pathophysiology of reproductive-related mood disorders. ..
  55. MOLECULAR BASIS OF ENTEROCYTE REGULATION DURING ONTOGENY
    Martin Martin; Fiscal Year: 2002
    ..Analysis of the FcRn and pIgR genes offers a unique model that may lead to a better understanding of the molecular mechanism of intestinal ontogeny, and specifically the intrinsic clock which controls its regulation. ..
  56. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  57. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  58. Prenatal diagnosis through selective DNA amplification
    Stephen Brown; Fiscal Year: 2009
    ..When and if such methods become available, they will revolutionize prenatal diagnosis and will represent a major milestone in the improvement of prenatal care. ..
  59. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  60. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  61. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..