endocrine system diseases

Summary

Summary: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.

Top Publications

  1. ncbi Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery
    Alexandra I Stavrakis
    Endocrine Surgical Unit and Center for Surgical Outcomes and Quality, VA Greater Los Angeles Healthcare System, Los Angeles, Calif, USA
    Surgery 142:887-99; discussion 887-99. 2007
  2. doi Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities
    Eugenia Resmini
    Department of Endocrinology and Medical Sciences, Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy
    Acta Diabetol 46:85-95. 2009
  3. ncbi Who performs endocrine operations in the United States?
    Brian D Saunders
    Department of Surgery, Divisions of Endocrine Surgery and Vascular Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 2920H, Ann Arbor, MI 48109 0331, USA
    Surgery 134:924-31; discussion 931. 2003
  4. pmc McCune-Albright syndrome
    Claudia E Dumitrescu
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Orphanet J Rare Dis 3:12. 2008
  5. ncbi Minireview: PRKAR1A: normal and abnormal functions
    Ioannis Bossis
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Endocrinology 145:5452-8. 2004
  6. ncbi Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome
    M Caldarelli
    Section of Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Rome, Italy
    Childs Nerv Syst 21:747-57. 2005
  7. ncbi Radical resection of craniopharyngioma
    Graciela Zuccaro
    Department of Neurosurgery, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Childs Nerv Syst 21:679-90. 2005
  8. ncbi Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma
    Indro Chakrabarti
    Department of Neurological Surgery, University of Southern California, Los Angeles, California 90032, USA
    J Neurosurg 102:650-7. 2005
  9. pmc A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems
    Piya Lahiry
    Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Am J Hum Genet 84:134-47. 2009
  10. ncbi The maturation of a specialty: Workforce projections for endocrine surgery
    Julie Ann Sosa
    Section of Endocrine Surgery, Department of Surgery, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Conn, USA
    Surgery 142:876-83. 2007

Detail Information

Publications197 found, 100 shown here

  1. ncbi Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery
    Alexandra I Stavrakis
    Endocrine Surgical Unit and Center for Surgical Outcomes and Quality, VA Greater Los Angeles Healthcare System, Los Angeles, Calif, USA
    Surgery 142:887-99; discussion 887-99. 2007
    ..We examined the effect of surgeon volume on clinical and economic outcomes for thyroid, parathyroid, and adrenal surgery across inpatient and outpatient settings...
  2. doi Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities
    Eugenia Resmini
    Department of Endocrinology and Medical Sciences, Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy
    Acta Diabetol 46:85-95. 2009
    ..Indeed, it has been demonstrated that insulin glargine, given once daily, reduces the risk of hypoglycaemia compared with other formulations, and can facilitate a more aggressive insulin treatment in this class of patients...
  3. ncbi Who performs endocrine operations in the United States?
    Brian D Saunders
    Department of Surgery, Divisions of Endocrine Surgery and Vascular Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 2920H, Ann Arbor, MI 48109 0331, USA
    Surgery 134:924-31; discussion 931. 2003
    ..Endocrine surgery is a discipline that is dedicated to high-quality care of patients with endocrine surgical disease. The relationship between its "identity" as a separate field and clinical practice patterns is not known...
  4. pmc McCune-Albright syndrome
    Claudia E Dumitrescu
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Orphanet J Rare Dis 3:12. 2008
    ..Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS...
  5. ncbi Minireview: PRKAR1A: normal and abnormal functions
    Ioannis Bossis
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Endocrinology 145:5452-8. 2004
    ....
  6. ncbi Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome
    M Caldarelli
    Section of Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Rome, Italy
    Childs Nerv Syst 21:747-57. 2005
    ..In order to avoid such complications, some authors have suggested to renounce to radical resection and to rely on post-operative radiation therapy to minimise the risk of residual tumour progression...
  7. ncbi Radical resection of craniopharyngioma
    Graciela Zuccaro
    Department of Neurosurgery, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Childs Nerv Syst 21:679-90. 2005
    ..Trying to remove a craniopharyngioma that has been treated previously with other methods is, in our experience, much more dangerous because of adherences of the tumor to vascular and neural structures...
  8. ncbi Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma
    Indro Chakrabarti
    Department of Neurological Surgery, University of Southern California, Los Angeles, California 90032, USA
    J Neurosurg 102:650-7. 2005
    ..More specifically, they evaluate the role of the TN approach in the management of craniopharyngioma...
  9. pmc A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems
    Piya Lahiry
    Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Am J Hum Genet 84:134-47. 2009
    ..We also demonstrate that the R272Q mutant fails to localize at the nucleus and has diminished kinase activity. These findings suggest that ICK plays a key role in the development of multiple organ systems...
  10. ncbi The maturation of a specialty: Workforce projections for endocrine surgery
    Julie Ann Sosa
    Section of Endocrine Surgery, Department of Surgery, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Conn, USA
    Surgery 142:876-83. 2007
    ..Fellowship programs will lead to more specialty-trained endocrine surgeons. We make projections for the supply of endocrine surgeons and demand for endocrine procedures over the next 15 years...
  11. ncbi Craniopharyngioma in children: Marseille experience
    Gabriel Lena
    Department of Pediatric Neurosurgery, hôpital des Enfants La Timone, 264, rue Saint Pierre, 13385, Marseille, Cedex 05, France
    Childs Nerv Syst 21:778-84. 2005
    ....
  12. ncbi Prevalence of symptomatic androgen deficiency in men
    Andre B Araujo
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 92:4241-7. 2007
    ..Despite recognition that androgen deficiency in men should be defined according to biochemical and clinical criteria, most prevalence estimates are based on low testosterone levels alone...
  13. ncbi Endocrine complications of hematopoietic stem cell transplantation
    Wassim Chemaitilly
    Department of Pediatrics, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, NY 11040, USA
    Endocrinol Metab Clin North Am 36:983-98; ix. 2007
    ..This article focuses on the late endocrine abnormalities that are most commonly observed following successful HSCT, with a special emphasis on pediatric HSCT recipients, for whom long-term follow-up data are increasingly available...
  14. ncbi Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology
    Bruno Ferraz de-Souza
    UCL Institute of Child Health and Department of Medicine, University College London, UK
    Pediatr Endocrinol Rev 3:359-64. 2006
    ....
  15. ncbi Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  16. ncbi Image diagnosis in McCune-Albright syndrome
    Claudio Defilippi
    Radiology Department, Regina Margherita Children s Hospital, Turin, Italy
    J Pediatr Endocrinol Metab 19:561-70. 2006
    ..Bone scintigraphy with technetium 99 is essential in the follow-up of the disease. Ultrasonography is very useful in ovarian cyst follow-up and in the detection of thyroid and adrenal nodules and testicular microlithiasis...
  17. ncbi Secondary causes of osteoporosis
    Lorraine A Fitzpatrick
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, and Internal Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 77:453-68. 2002
    ..This article provides the framework for understanding causes of bone loss and approaches to their management...
  18. ncbi Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach
    Elisabeth F C van Rossum
    University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 20:611-26. 2006
    ..Diagnosis of generalized GC resistance can be difficult. This review highlights the diagnostic process and therapeutic options for treating patients with this disease...
  19. ncbi Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence
    S Shalitin
    Institute for Endocrinology and Diabetes, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 49202, Israel
    Bone Marrow Transplant 37:1109-17. 2006
    ..9% of the 43 patients tested. These findings emphasize the need for long-term follow-up of endocrine and metabolic parameters in young patients after BMT in order to offer proper treatment and improve quality of life...
  20. ncbi McCune-Albright syndrome and disorders due to activating mutations of GNAS1
    Alejandro Diaz
    Division of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, NY, USA
    J Pediatr Endocrinol Metab 20:853-80. 2007
    ..We discuss here the clinical consequences of GNAS1 activating mutations in different body systems and organs, the diagnostic approach to MAS, and the current therapeutic recommendations...
  21. ncbi Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7152-60. 2005
    ....
  22. ncbi Late endocrine, metabolic and skeletal sequelae following treatment of childhood cancer
    Helena K Gleeson
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester, Withington, M20 4BX, UK
    Best Pract Res Clin Endocrinol Metab 16:335-48. 2002
    ..In this review we consider the following potential problems: growth hormone deficiency and replacement in adulthood, cardiovascular risk factors, osteopaenia, thyroid and parathyroid dysfunction...
  23. ncbi Endocrine abnormalities in patients with Fanconi anemia
    Neelam Giri
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard EPS 7024, Rockville, Maryland 20852, USA
    J Clin Endocrinol Metab 92:2624-31. 2007
    ..Fanconi anemia (FA) is an inherited disorder with chromosomal instability, bone marrow failure, developmental defects, and a predisposition to cancer. Systematic and comprehensive endocrine function data in FA are limited...
  24. ncbi Endocrine late effects from multi-modality treatment of neuroblastoma
    H M van Santen
    Department of Paediatric Endocrinology, Emma Children s Hospital AMC, G8 205, Academic Medical Center AMC, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur J Cancer 41:1767-74. 2005
    ..We recommend that during follow-up of neuroblastoma children, special attention should be paid to their endocrine state...
  25. ncbi Endocrine sequelae of cancer therapy in childhood
    F B Diamond
    Department of Pediatrics University of South Florida College of Medicine, Tampa, USA
    J Endocrinol Invest 24:648-58. 2001
    ..These include effects on growth, puberty, fertility, thyroid and adrenal function which may present many years after the successful treatment of underlying disease...
  26. ncbi Admission and discharge guidelines for the pediatric patient requiring intermediate care
    David G Jaimovich
    Hope Children s Hospital, Oak Lawn, IL, USA
    Crit Care Med 32:1215-8. 2004
    ..This level of care may enhance the efficiency of care and improve the healthcare affordability for patients receiving intermediate care...
  27. ncbi The late effects of childhood cancer therapy
    Joseph D Dickerman
    University of Vermont College of Medicine, Department of Pediatrics, 89 Beaumont Ave, Given D201, Burlington, VT 05405 0068, USA
    Pediatrics 119:554-68. 2007
    ..A table listing radiation-therapy site and chemotherapeutic agents and selected late effects that result from their use is provided. Finally, a brief recommendation regarding the establishment of a late-effects clinic is also presented...
  28. ncbi [Etiology and blood pressure patterns in secondary hypertension in children]
    Cristina Gavrilovici
    Clinica a IV a Pediatrie, Facultatea de Medicina, Universitatea de Medicină şi Farmacie Gr T Popa, Iasi
    Rev Med Chir Soc Med Nat Iasi 111:70-81. 2007
    ..10%), with a probability of identifying an underlying disease inversely related with the age and directly related with the severity of hypertension...
  29. ncbi Opiate drug use: a potential contributor to the endocrine and metabolic complications in human immunodeficiency virus disease
    Odelia B Cooper
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 37:S132-6. 2003
    ..Although much of the evidence should be viewed as preliminary, these potential abnormalities should be kept in mind when treating opiate-dependent patients infected with HIV...
  30. ncbi Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF)
    Vincenzo De Sanctis
    Department of Reproduction and Growth, Pediatric and Adolescent Unit, Arcispedale S Anna, Ferrara, Italy
    Pediatr Endocrinol Rev 2:249-55. 2004
    ..In conclusion, since iron overload and liver damage seem to be the most important factors responsible for endocrine complications, adequate compliance to chelation therapy and rigid precautions against liver infections are imperative...
  31. ncbi [Severe chronic anemia and endocrine disorders in children]
    Michael Hauschild
    Unité d endocrinologie diabétologie pédiatrique, Département médico chirurgical de pédiatrie, CHUV, 1011 Lausanne
    Rev Med Suisse 3:988-91. 2007
    ..Diabetes mellitus, hypothyroidism and hypoparathyroidism may also develop. Follow-up includes close monitoring of growth and pubertal development in order to guide therapeutic interventions...
  32. ncbi The pre-operative endocrine assessment of craniopharyngiomas
    Neil Hopper
    Department of Paediatric Endocrinology, St George s Hospital, London, UK
    J Pediatr Endocrinol Metab 19:325-7. 2006
    ..We review the available published data on pre-operative endocrine dysfunction and suggest an approach to assessment and management before surgery...
  33. ncbi Endocrine gland abnormalities in thalassemia major: a brief review
    Sakineh Mohammadian
    Department of Pediatrics, Golestan University of Medical Sciences, Gorgan, Iran
    J Pediatr Endocrinol Metab 16:957-64. 2003
    ..In this article we briefly review the current understanding of endocrine gland abnormalities, primarily caused by iron overload, in patients with thalassemia major...
  34. ncbi Comparison of oral and subcutaneous iron chelation therapies in the prevention of major endocrinopathies in beta-thalassemia major patients
    Chung Hsing Wang
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    Hemoglobin 30:257-62. 2006
    ....
  35. ncbi Endocrinological late effects following radiotherapy and chemotherapy of childhood brain tumours
    Marianne Schmiegelow
    Department of Endocrinology, Abdominal Centre, University Hospitality, H S Rigshospitalet, Copenhagen, Denmark
    Dan Med Bull 53:326-41. 2006
  36. ncbi Low bone mineral density in adolescents with beta-thalassemia
    Maria G Vogiatzi
    Department of Pediatrics, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Ann N Y Acad Sci 1054:462-6. 2005
    ..Thus, calcium and vitamin D supplementation with antiresorptive therapies should be evaluated in the adolescent Thal pt with close monitoring of growth and sexual development...
  37. ncbi Update on autoimmune polyendocrine syndromes (APS)
    Corrado Betterle
    Clinical Immunology and Allergology, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Acta Biomed 74:9-33. 2003
    ....
  38. ncbi [Werner's syndrome and endocrine disorders]
    B Zantour
    Service de Médecine Interne et Endocrinologie, CHU Tahar Sfar, Mahdia, Tunisie
    Ann Endocrinol (Paris) 64:205-9. 2003
    ..Thus, in Werner's syndrome metabolic and endocrinologic investigation is necessary in order to treat these disorders and improve the patient's prognosis and life...
  39. ncbi Clinical uses and misuses of dehydroepiandrosterone
    Emanuela Binello
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    Curr Opin Pharmacol 3:635-41. 2003
    ..Research is ongoing at both the basic and the clinical level to elucidate mechanisms of action and establish efficacy and safety, as well as to expand new areas of potential application for this multi-faceted hormone...
  40. ncbi Endocrine and metabolic manifestations of invasive fungal infections and systemic antifungal treatment
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mayo Clin Proc 83:1046-60. 2008
    ..If clinicians are equipped with better knowledge of the endocrine and metabolic complications of fungal infections and antifungal therapy, they can more readily recognize them and favorably affect outcome...
  41. ncbi Drug-induced endocrine and metabolic disorders
    Ronald C W Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Drug Saf 30:215-45. 2007
    ....
  42. ncbi Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 45:771-91. 2006
    ..Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications...
  43. ncbi Indications for synergetic and antagonistic effects between trace elements in the environment to human health
    Jasmina Obhodas
    Experimental Physics Department, Institute Ruder Boskovic, Zagreb, Croatia
    Coll Antropol 31:209-19. 2007
    ..The results reported here emphasize the importance of the observation of the mutual effects of the environmental variables on the human health for the identification of their synergetic as well as antagonistic effects...
  44. ncbi Medical causes of headache in children
    Nicholas S Abend
    Department of Neurology, The University of Pennsylvania School of Medicine, and Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Pain Headache Rep 11:401-7. 2007
    ..Medical causes of headache are so diverse that uniform screening tests are not useful. History and examination must guide the differential diagnosis, and management plans must be individualized...
  45. ncbi Recognition and treatment of endocrine/metabolic emergencies in children: part I
    Michael S Kappy
    University of Colorado Health Sciences Center, The Children s Hospital, Denver, USA
    Adv Pediatr 49:245-72. 2002
    ..Prompt diagnosis depends on the collection of critical and archival laboratory specimens before the administration of nonspecific therapy...
  46. ncbi Tremor in children
    Mohammad K Uddin
    Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Semin Pediatr Neurol 10:26-34. 2003
    ..This review covers the etiology, clinical features, and treatment of the major tremor syndromes in children, and when appropriate, makes comparisons with similar disorders in adults...
  47. ncbi Late health effects of childhood nasopharyngeal radium irradiation: nonmelanoma skin cancers, benign tumors, and hormonal disorders
    Cécile M Ronckers
    Department of Ear, Nose and Throat Medicine, Reinaert Kliniek, Maastricht, The Netherlands
    Pediatr Res 52:850-8. 2002
    ..0-2.1). We found no evidence of highly elevated risk of benign head and neck tumors, nonmelanoma skin cancer, thyroid disorders, or indicators of pituitary radiation damage after childhood NRI in The Netherlands...
  48. ncbi Pediatric thyroid testing issues
    Mark D DeBoer
    Department of Pediatrics, Division of Endocrinology, University of Virginia, VA, USA
    Pediatr Endocrinol Rev 5:570-7. 2007
    ..Additionally, heterophile and anti-T4 or anti-TSH antibodies can interfere with accurate T4 or TSH measurement...
  49. ncbi Impact of thalassemia major on patients and their families
    J Jaime Caro
    Caro Research Institute, Concord, MA 07142, USA
    Acta Haematol 107:150-7. 2002
    ..To describe the burden of thalassemia major and its treatment, in terms of prevalence of iron-overload-related complications, direct and indirect costs, and the patient's physical and social well-being...
  50. ncbi Endocrine manifestations of chromosome 22q11.2 microdeletion syndrome
    Jin Ho Choi
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Horm Res 63:294-9. 2005
    ..2 microdeletion syndrome. This study was undertaken to examine the frequencies and clinical features of endocrine abnormalities in patients with 22q11.2 microdeletion syndrome...
  51. ncbi [Adverse effects of psychotropic agents]
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine
    Nihon Rinsho 65:247-53. 2007
  52. ncbi Sleep apnea and sports performance
    Helene A Emsellem
    The Center for Sleep and Wake Disorders, 5454 Wisconsin Avenue, Suite 1725, Chevy Chase, MD 20815, USA
    Clin Sports Med 24:329-41, x. 2005
    ..A high index of suspicion for apnea should exist, particularly in those who have anatomic features and symptoms consistent with the disorder. This article reviews pathophysiology, diagnostic modalities, and treatment interventions...
  53. ncbi [New advances in drug therapy in 2003-2004]
    A J Scheen
    Universite de Liege, Service de Médecine interne générale et Service de Diabétologie, Nutrition et Maladies Metaboliques, Departement de Medecine
    Rev Med Liege 59:385-402. 2004
    ..Most of them are currently studied in order to further demonstrate their potential benefit on a long-term basis, in large cohort of patients and using hard clinical endpoints...
  54. ncbi Endocrine complications of neoplastic diseases in children and adolescents
    H K Gleeson
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Curr Opin Pediatr 13:346-51. 2001
    ....
  55. ncbi Drosophila melanogaster as a model system for drug discovery and pathway screening
    Sanjay Tickoo
    Department of Genetics, University of Cambridge, UK
    Curr Opin Pharmacol 2:555-60. 2002
    ....
  56. ncbi Endocrine and metabolic deficiency
    Gregory F Wu
    Department of Neurology, University of Pennsylvania School of Medicine, 3 E Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ophthalmol Clin North Am 17:427-34, vii. 2004
    ....
  57. ncbi [The numbers of patients with endocrine disorders are increasing. Who will be responsible for them in the future?]
    Mann Klaus
    Klinik fur Endokrinologie, Universitatsklinikum Essen
    MMW Fortschr Med 148:25-6. 2006
  58. ncbi Critical issues in endocrinology
    Philip A Goldberg
    Section of Endocrinology, Yale University School of Medicine, TMP 534, 333 Cedar Street, New Haven, CT 06520, USA
    Clin Chest Med 24:583-606, vi. 2003
    ..Other endocrine issues that are related to intensive care, such as intensive insulin therapy, relative adrenal insufficiency, and thyroid function test abnormalities are also covered in detail...
  59. ncbi A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Medicine (Baltimore) 86:215-24. 2007
    ..2%, and male hypogonadism 20.3%. Coexistence of multiple late sequelae was common in HSCT survivors. Our findings provide a basis for more effective patient counseling, optimal surveillance, and early intervention...
  60. ncbi [Hormone therapies in pregnancy]
    G A Tommaselli
    Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Universita Degli Studi Di Napoli, Federico II, Napoli, Italy
    Minerva Ginecol 54:145-50. 2002
    ..In this review, the incidence of the main endocrine disorders, their evolution during pregnancy, their effects on mothers and fetuses and new acquisition on the treatment during pregnancy are discussed...
  61. ncbi Endothelial dysfunction in endocrine disease
    T A Abdu
    Dept of Medicine, School of Postgraduate Medicine, Keele University, Staffordshire, ST4 7QB, Keele, UK
    Trends Endocrinol Metab 12:257-65. 2001
    ....
  62. ncbi Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications
    N A Aziz
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Rev Neurosci 18:223-51. 2007
    ....
  63. ncbi Endocrine and growth features in childhood craniopharyngioma: a mono-institutional study
    Eliana di Battista
    Auxoendocrinological Centre, Paediatric Department, University of Genoa, School of Medicine, Italy
    J Pediatr Endocrinol Metab 19:431-7. 2006
    ..To evaluate growth and endocrine features in children with craniopharyngioma who were treated and followed up by a single institution between 1976 and 2004...
  64. ncbi Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003
    Martin Benesch
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria
    J Neurooncol 78:199-205. 2006
    ..As long-term survival is excellent in patients with low-grade gliomas except for tumors located in the brainstem, future treatment studies should focus on avoiding long-term late effects...
  65. ncbi Nonmalignant late effects after allogeneic stem cell transplantation
    Gerard Socie
    Hematology Stem Cell Transplantation, Hopital Saint Louis, Paris, France
    Blood 101:3373-85. 2003
  66. ncbi Definable somatic disorders in overweight children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr 150:618-22, 622.e1-5. 2007
    ..To analyze the frequencies and clinical presentation of definable somatic disorders in children who are overweight...
  67. pmc Atypical psychotropic medications and their adverse effects: a review for the African-American primary care physician
    Rahn Kennedy Bailey
    University of Texas Medical School at Houston, USA
    J Natl Med Assoc 95:137-44. 2003
    ..A particular focus will address the increasing concern that these new medications can produce hyperglycemia and diabetes mellitus...
  68. ncbi Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence
    Leslie L Robison
    Division of Pediatric Epidemiology and Clinical Research, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Br J Haematol 122:345-59. 2003
  69. ncbi Long-term endocrine effects of cancer treatment: experience of the Royal Children's Hospital, Melbourne
    R Hameed
    Department of Endocrinology and Diabetes, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 41:36-42. 2005
    ..To evaluate the frequency and degree of severity of endocrine late effects in patients treated for childhood cancer and to assess the value of the late effects clinic for continued monitoring of these patients...
  70. ncbi Posterior ocular malformations in children: somatic, neuroradiological and cognitive aspects
    K Tear Fahnehjelm
    Department of Clinical Science, Division of Paediatric Ophthalmology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Acta Paediatr 92:301-8. 2003
    ..To investigate associated neurological, endocrinological and cognitive dysfunctions in children with visual impairment caused by optic nerve hypoplasia or optic nerve/fundus coloboma and/or microphthalmus...
  71. ncbi Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 97:663-73. 2003
    ....
  72. ncbi Pesticides and children
    Vincent F Garry
    Department of Laboratory Medicine and Pathology and Program in Toxicology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Toxicol Appl Pharmacol 198:152-63. 2004
    ..The level of consensus among these studies is examined. Current concerns regarding neurobehavioral toxicity and endocrine disruption in juxtaposition to the relative paucity of toxicant mechanism-based studies of children are explored...
  73. ncbi Sexual symptoms in endocrine diseases: psychosomatic perspectives
    Giancarlo Balercia
    Endocrinology, Andrology Unit, Department of Clinical Medicine and Applied Biotechnologies, Polytechnic University of Marche, Ancona, Italy
    Psychother Psychosom 76:134-40. 2007
    ..may have a greater or lesser effect on sexual function...
  74. ncbi Endocrine abnormalities in patients with frontoethmoidal encephalomeningocele. A preliminary study
    S Wacharasindhu
    Endocrine Unit, Department of Pediatrics, Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
    Horm Res 64:64-7. 2005
    ..Frontoethmoidal encephalomeningocele (FEEM) is a congenital neural tube defect which is more common in Southeast Asia. Its etiology is unknown. No one has ever reported endocrine abnormalities in this condition...
  75. ncbi Gender differences in GAD antibody-positive diabetes mellitus in relation to age at onset, C-peptide and other endocrine autoimmune diseases
    Eero Lindholm
    Department of Endocrinology, University Hospital, Malmo, Sweden
    Diabetes Metab Res Rev 20:158-64. 2004
    ....
  76. ncbi Craniopharyngioma radiotherapy: endocrine and cognitive effects
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38104, USA
    J Pediatr Endocrinol Metab 19:439-46. 2006
    ..Early and accurate evaluation of these functions should be considered for all patients to provide parents and caregivers with the information necessary to plan intervention and mitigate the consequences of tumor and treatment...
  77. ncbi Updates in pediatric endocrinology
    Manmohan K Kamboj
    Wexner Medical Center at The Ohio State University, Section of Endocrinology, Metabolism and Diabetes, Nationwide Children s Hospital, 700 Children s Drive ED425, Columbus, OH 43205, USA
    Adolesc Med State Art Rev 24:108-32, xii. 2013
    ....
  78. ncbi Phenotypic subgroups of polycystic ovary syndrome have different intra-renal resistance symptoms
    Ceylan F Ciftci
    Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Konya, Turkey
    Ginekol Pol 83:910-5. 2012
    ..In this study we examined whether PCOS subgroups have different intra-renal resistance symptoms...
  79. doi Metabolic syndrome and endocrine dysfunctions after HSCT in children
    Rajinder Bajwa
    Department of Hematology Oncology BMT, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Pediatr Transplant 16:872-8. 2012
    ..05). Uniform diagnostic criteria for MS and close follow-up after transplant are important for the early diagnosis and management of these late effects, thereby improving the overall quality of life of these patients...
  80. doi Common endocrine issues in the pediatric intensive care unit
    Amélie von Saint André-von Arnim
    Seattle Children s Hospital, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Crit Care Clin 29:335-58. 2013
    ..Severe deficiency or excess of thyroid hormone both represent life-threatening disease, which must be treated expeditiously and thoroughly. Such deficiencies must be considered, because presentation may be nonspecific...
  81. ncbi Pattern of non-communicable diseases among medical admissions in Port Harcourt, Nigeria
    C N Unachukwu
    Department of Medicine, University of Port Harcourt Teaching Hospital, Nigeria
    Niger J Clin Pract 11:14-7. 2008
    ..To determine the pattern of non-communicable diseases in the medical wards of the University of Port Harcourt Teaching Hospital (UPTH), over four consecutive years (June 2000 to June 2004)...
  82. ncbi Long-term effects of treatments for childhood cancers
    Jorge A Alvarez
    Department of Pediatrics, University of Miami Jackson Memorial Medical Center, Miami, Florida, USA
    Curr Opin Pediatr 19:23-31. 2007
    ..We selectively review the negative late cardiac, endocrine, and neurological effects of childhood cancer and its treatments and comment on current research and recommendations for the care of long-term survivors of childhood cancer...
  83. ncbi Celiac disease and the endocrinologist: a diagnostic opportunity
    Arthur H Fisher
    Endocrinology and Diabetes Associates of Long Island, Rockville Centre, New York 11570, USA
    Endocr Pract 14:381-8. 2008
    ..To review the association of celiac disease and various endocrine disorders and present the related clinical experience of a 3-physician adult endocrinology practice...
  84. ncbi Autoimmune polyendocrinopathy associated with ring chromosome 18
    Nina Jain
    Department of Pediatrics, Division of Pediatric Endocrinology, CB 7039, 3341 MBRB, University of North Carolina, Chapel Hill, NC 27599 703, USA
    J Pediatr Endocrinol Metab 24:847-50. 2011
    ..3-18pter). Although this unique association of autoimmune polyglandular endocrinopathy with ring chromosome 18 could be coincidental, we speculate that a gene or genes on chromosome 18 might play a role in the autoimmune process...
  85. doi Medical comorbidity affects antidepressant treatment response in patients with melancholic depression
    K Pohle
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Psychother Psychosom 78:359-63. 2009
    ..This study aimed at the impact of medical comorbidity (MC) on response to antidepressant treatment over 6 weeks in diagnostic subtypes of patients with major depressive episode (MDE)...
  86. ncbi Medical disorders and their effects on sleep
    Teofilo L Lee-Chiong
    National Jewish Medical and Research Center, 1400 Jackson Street, Room J232, Denver, CO 80206, USA
    Respir Care Clin N Am 12:55-69, viii. 2006
    ..More than one sleep pathology may be present in a particular patient, and these disorders may interact to increase the severity or prolong the duration of sleep disturbance...
  87. ncbi Genomics in pediatric endocrinology--genetic disorders and new techniques
    Alfred Tenore
    Division of Pediatric Endocrinology, Department of Pediatrics DPMSC, University of Udine School of Medicine, Padiglione Petracco, Piazzale S M della Misericordia, 33100, Udine, Italy
    Endocrinol Metab Clin North Am 38:471-90. 2009
    ..This article introduces some of these concepts and some of the genetic techniques being used...
  88. doi Aetiology and pathogenesis of IUGR
    Srividhya Sankaran
    Guy s and St Thomas NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK
    Best Pract Res Clin Obstet Gynaecol 23:765-77. 2009
    ..While the research into the pathophysiology of IUGR continues, there have been interesting discoveries related to the genetic contribution to IUGR and the intrauterine programming of adult-onset diseases attributed to IUGR...
  89. ncbi Multiple endocrine diseases in cats: 15 cases (1997-2008)
    Shauna L Blois
    Department of Clinical Studies, Ontario Veterinary College Teaching Hospital, University of Guelph, Guelph, Ontario, Canada
    J Feline Med Surg 12:637-42. 2010
    ..A mean of 25.7 months elapsed between diagnoses of the first and second endocrine disorder, but this was variable. This study suggests the occurrence of multiple endocrine disorders is uncommon in cats...
  90. ncbi Neuroendocrine dysfunction in fibromyalgia and migraine
    Marcelo Moraes Valenca
    Instituto Israelita deEnsino e Pesquisa Hospital Albert Einstein, Sao Paulo, Brazil
    Curr Pain Headache Rep 13:358-64. 2009
    ..Understanding their mechanisms will help to establish new treatment strategies for treating these disabling brain disorders...
  91. doi Endocrinopathy, vision, headache, and recurrence after transsphenoidal surgery for Rathke cleft cysts
    Scott D Wait
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neurosurgery 67:837-43; discussion 843. 2010
    ..Rathke cleft cyst can enlarge and become symptomatic...
  92. doi Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
    Soo Hyun Kim
    Division of Biomedical Sciences, St George s Medical School, University of London, Cranmer Terrace, London, UK
    J Endocrinol 209:139-51. 2011
    ....
  93. doi Medical history screening for thrombophilic risk: is this adequate?
    Waltraud Eggert-Kruse
    Department of Gynecological Endocrinology and Reproductive Medicine, Women s Hospital, University of Heidelberg, Heidelberg, Germany
    Fertil Steril 95:1917-21. 2011
    ..To evaluate the reliability of medical history taken before hormonal medication administration to identify women with an increased risk for thromboembolic events detected by laboratory screening...
  94. doi Chiari malformation type I: related conditions
    Ruth Mary Desouza
    Department of Surgery, University Hospital, Coventry and Warwickshire, UK
    Neurol Res 33:278-84. 2011
    ..Identifying the relationship between CMI and these associated disorders may allow greater understanding of CMI etiology and potentially inform CMI management...
  95. ncbi Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption
    Michael H Hsieh
    Scott Department of Urology, Texas Children s Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA
    Curr Urol Rep 9:137-42. 2008
    ..Hence, human hypospadias and cryptorchidism may be associated with reduced anogenital distance as a result of endocrine disruption...
  96. ncbi Upregulated expression of PDGF receptor beta in endocrine pancreatic tumors and metastases compared to normal endocrine pancreas
    Marie Louise Fjällskog
    Department of Oncology, University Hospital, Uppsala, Sweden
    Acta Oncol 46:741-6. 2007
    ..This is also true for PDGFR beta expression in the corresponding stroma. We suggest that new therapeutic options to inhibit the growth and spread of EPTs could include targeting of PDGFR beta...
  97. ncbi Pruritus in systemic disease: mechanisms and management
    Lawrence Etter
    Division of Dermatology, Center for Aesthetic Services, Duke University Medical Center, 1300 Morreene Road, Durham, NC 27705, USA
    Dermatol Clin 20:459-72, vi-vii. 2002
    ....
  98. ncbi 11th International Congress of Endocrinology
    P J Fuller
    Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
    Expert Opin Investig Drugs 10:569-76. 2001
    ..With five concurrent symposia and two concurrent orals each morning and afternoon of the four days, any omissions reflect not on the topic or its importance but on this reviewer's inability to be in more than one place at once!..
  99. ncbi [Pathological cataracts in systemic diseases]
    Catalina Corbu
    Oftalmologia 49:50-3. 2005
    ..To show the physiopathological mechanisms which determines the appearance of the pathological cataract and types of cataract and clinical manifestations of the systemic disease and operative complications...
  100. ncbi Myths about endocrine disruption and the male reproductive system should not be propagated
    Mike Joffe
    Hum Reprod 17:520-3. 2002
  101. ncbi Endocrine manifestations of craniopharyngioma
    Isil Halac
    Division of Endocrinology, Children s Memorial Hospital, 2300 Children s Plaza, P O Box 54, Chicago, IL 60614, USA
    Childs Nerv Syst 21:640-8. 2005
    ..After treatment, these impairments can become a major cause of morbidity and mortality...

Research Grants96

  1. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2010
    ....
  2. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2007
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  3. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban Harlow; Fiscal Year: 2008
    ....
  4. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2006
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  5. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2002
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  6. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban Harlow; Fiscal Year: 2009
    ....
  7. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2009
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  8. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2008
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  9. Stress, hypercortisolism, and metabolic risk factors
    Sherita Golden; Fiscal Year: 2008
    ....
  10. Staging Reproductive Aging in Five Cohort Studies
    Sioban Harlow; Fiscal Year: 2003
    ..This information will help clarify our understanding of ovarian aging, permit researchers to more adequately control for menopausal status, and facilitate decision-making among women and their providers. ..
  11. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  12. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  13. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  14. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2007
    ....
  15. TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIA
    Shalendar Bhasin; Fiscal Year: 2007
    ..The study will provide unique information about the effectiveness of a rational, but hitherto unproven therapeutic strategy, for older men with sarcopenia who are at increased risk of disability. ..
  16. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007
    ..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  17. Zinc and Bone Metabolism in Thalassemia
    Ellen Fung; Fiscal Year: 2007
    ....
  18. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  19. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2006
    ..abstract_text> ..
  20. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  21. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  22. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2007
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  23. Optimizing Protein Intake in Older Americans with Mobility Limitations
    SHALENDAR contact BHASIN; Fiscal Year: 2010
    ..This issue has enormous public health and policy implications for older Americans. ..
  24. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2010
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  25. Population-Based Reference Ranges for Testosterone
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  26. Human Senescence and Cardioprotection
    Arshad Jahangir; Fiscal Year: 2010
    ..This information is of high public health interest, since cardiovascular diseases continue to be the leading cause of disability in the elderly. ..
  27. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2010
    ....
  28. Mechanisms of Testosterone Action
    Shalendar Bhasin; Fiscal Year: 2010
    ..The proposed project also provides an outstanding opportunity to further our understanding of hormonal regulation of stem cell differentiation and cell fate. ..
  29. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  30. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2009
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  31. Population-Based Reference Ranges for Testosterone
    Shalendar Bhasin; Fiscal Year: 2009
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  32. TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIA
    Shalender Bhasin; Fiscal Year: 2008
    ..The study will provide unique information about the effectiveness of a rational, but hitherto unproven therapeutic strategy, for older men with sarcopenia who are at increased risk of disability. ..
  33. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2008
    ....
  34. Human Senescence and Cardioprotection
    Arshad Jahangir; Fiscal Year: 2008
    ..This information is of high public health interest, since cardiovascular diseases continue to be the leading cause of disability in the elderly. ..
  35. METABOLISM, ENDOCRINOLOGY AND OBESITY TRAINING GRANT
    Shalendar Bhasin; Fiscal Year: 2008
    ..D.-Ph.D. candidates, expansion of the program from 6 (3 pre-doctoral and 3 post-doctoral) to 7 positions (4 pre-doctoral and 3 post-doctoral) is requested. ..
  36. Boston OAIC: A Translational Approach to Function Promoting Anabolic Therapies
    Shalendar Bhasin; Fiscal Year: 2008
    ..Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers. PROGRAM AS A WHOLE ..
  37. TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIA
    Shalendar Bhasin; Fiscal Year: 2008
    ..The study will provide unique information about the effectiveness of a rational, but hitherto unproven therapeutic strategy, for older men with sarcopenia who are at increased risk of disability. ..
  38. Population-Based Reference Ranges for Testosterone
    Shalendar Bhasin; Fiscal Year: 2008
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  39. Zinc and Bone Metabolism in Thalassemia
    Ellen Fung; Fiscal Year: 2008
    ....
  40. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2005
    ..abstract_text> ..
  41. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2003
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  42. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2002
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  43. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2002
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  44. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  45. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2000
    ....
  46. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  47. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 1999
    ....
  48. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2003
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  49. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  50. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2005
    ..abstract_text> ..
  51. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  52. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  53. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  54. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2005
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  55. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2004
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  56. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  57. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2003
    ..These studies will provide fundamental insights into the (patho) physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  58. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalender Bhasin; Fiscal Year: 2005
    ....
  59. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2001
    ....
  60. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2006
    ..abstract_text> ..
  61. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2001
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  62. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  63. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2002
    ....
  64. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalender Bhasin; Fiscal Year: 2006
    ....
  65. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2003
    ..abstract_text> ..
  66. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2006
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  67. CONTROL OF FIBROBLAST REPLICATION BY IGF-I
    David Clemmons; Fiscal Year: 1991
    ..The results of these studies should provide basic information that is necessary to construct valid hypotheses regarding the role of growth factors in the response to injury and cellular aging...
  68. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2004
    ....
  69. A study of Model Beta-cells in Diabetes Treatment
    Nicholas Simpson; Fiscal Year: 2007
    ..Proposed experiments are founded on strong preliminary data and we are confident that they will pave the way for further imaging studies in tissue engineering. ..
  70. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2002
    ..abstract_text> ..
  71. Evaluation of Cardiovascular Outcomes Among Childhood Cancer Survivors
    Melissa Hudson; Fiscal Year: 2009
    ..We expect the intervention to increase childhood cancer survivors'CV screening adherence, and therefore potentially significantly modify the morbidity and mortality of CV disease in this at-risk population. ..
  72. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2003
    ....
  73. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2002
    ..The applicant expects these studies to be the basis for future clinical trials. ..
  74. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2005
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  75. 3/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)
    Christoph Correll; Fiscal Year: 2009
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  76. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  77. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2000
    ..The applicant expects these studies to be the basis for future clinical trials. ..
  78. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2007
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..