sprains and strains

Summary

Summary: A collective term for muscle and ligament injuries without dislocation or fracture. A sprain is a joint injury in which some of the fibers of a supporting ligament are ruptured but the continuity of the ligament remains intact. A strain is an overstretching or overexertion of some part of the musculature.

Top Publications

  1. ncbi Arthrogenic muscle inhibition in the leg muscles of subjects exhibiting functional ankle instability
    Eric D McVey
    University of Virginia, Department of Human Services, P O Box 400407, 210 Emmet Street South, Charlottesville, VA 22904, USA
    Foot Ankle Int 26:1055-61. 2005
  2. doi Hamstring strain injuries: factors that lead to injury and re-injury
    David A Opar
    School of Human Movement Studies and Institute of Health Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    Sports Med 42:209-26. 2012
  3. pmc The Football Association Medical Research Programme: an audit of injuries in professional football--analysis of hamstring injuries
    C Woods
    The English Institute of Sport
    Br J Sports Med 38:36-41. 2004
  4. pmc Epidemiology of injuries in the Australian Football League, seasons 1997-2000
    J Orchard
    University of Melbourne, Australia AFL Medical Officers Association, Melbourne, Australia
    Br J Sports Med 36:39-44. 2002
  5. ncbi Acute first-time hamstring strains during high-speed running: a longitudinal study including clinical and magnetic resonance imaging findings
    Carl M Askling
    Swedish School of Sport and Health Sciences, Stockholm, Sweden
    Am J Sports Med 35:197-206. 2007
  6. doi Mechanical supports for acute, severe ankle sprain: a pragmatic, multicentre, randomised controlled trial
    S E Lamb
    Warwick Clinical Trials Unit, Medical School, University of Warwick, Coventry, UK
    Lancet 373:575-81. 2009
  7. ncbi Incidence, risk, and prevention of hamstring muscle injuries in professional rugby union
    John H M Brooks
    Rugby Football Union, Twickenham, United Kingdom
    Am J Sports Med 34:1297-306. 2006
  8. ncbi A comparison of 2 rehabilitation programs in the treatment of acute hamstring strains
    Marc A Sherry
    University of Wisconsin Health Sports Medicine Center, Madison, WI, USA
    J Orthop Sports Phys Ther 34:116-25. 2004
  9. ncbi Balance as a predictor of ankle injuries in high school basketball players
    T A McGuine
    Athletic Training Program, University of Wisconsin Health Sports Medicine Center, Madison 53711, USA
    Clin J Sport Med 10:239-44. 2000
  10. doi Occurrence of injuries and illnesses during the 2009 IAAF World Athletics Championships
    Juan Manuel Alonso
    International Association of Athletics Federations IAAF, Monaco
    Br J Sports Med 44:1100-5. 2010

Detail Information

Publications237 found, 100 shown here

  1. ncbi Arthrogenic muscle inhibition in the leg muscles of subjects exhibiting functional ankle instability
    Eric D McVey
    University of Virginia, Department of Human Services, P O Box 400407, 210 Emmet Street South, Charlottesville, VA 22904, USA
    Foot Ankle Int 26:1055-61. 2005
    ..The purpose of this investigation was to determine if arthrogenic muscle inhibition is present in the ankle joint musculature of patients exhibiting unilateral functional ankle instability...
  2. doi Hamstring strain injuries: factors that lead to injury and re-injury
    David A Opar
    School of Human Movement Studies and Institute of Health Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    Sports Med 42:209-26. 2012
    ..This remains an area for future research and practitioners need to remain aware of the multifactoral nature of HSIs if injury rates are to decline...
  3. pmc The Football Association Medical Research Programme: an audit of injuries in professional football--analysis of hamstring injuries
    C Woods
    The English Institute of Sport
    Br J Sports Med 38:36-41. 2004
    ..To conduct a detailed analysis of hamstring injuries sustained in English professional football over two competitive seasons...
  4. pmc Epidemiology of injuries in the Australian Football League, seasons 1997-2000
    J Orchard
    University of Melbourne, Australia AFL Medical Officers Association, Melbourne, Australia
    Br J Sports Med 36:39-44. 2002
    ..To describe the epidemiology of injuries in the Australian Football League (AFL) over four seasons...
  5. ncbi Acute first-time hamstring strains during high-speed running: a longitudinal study including clinical and magnetic resonance imaging findings
    Carl M Askling
    Swedish School of Sport and Health Sciences, Stockholm, Sweden
    Am J Sports Med 35:197-206. 2007
    ..Hamstring muscle strain is one of the most common injuries in sports. Still, knowledge is limited about the progression of clinical and magnetic resonance imaging characteristics and their association with recovery time in athletes...
  6. doi Mechanical supports for acute, severe ankle sprain: a pragmatic, multicentre, randomised controlled trial
    S E Lamb
    Warwick Clinical Trials Unit, Medical School, University of Warwick, Coventry, UK
    Lancet 373:575-81. 2009
    ....
  7. ncbi Incidence, risk, and prevention of hamstring muscle injuries in professional rugby union
    John H M Brooks
    Rugby Football Union, Twickenham, United Kingdom
    Am J Sports Med 34:1297-306. 2006
    ..The incidence of hamstring muscle injuries in professional rugby union is high, but evidence-based information on risk factors and injury-prevention strategies in this sport is limited...
  8. ncbi A comparison of 2 rehabilitation programs in the treatment of acute hamstring strains
    Marc A Sherry
    University of Wisconsin Health Sports Medicine Center, Madison, WI, USA
    J Orthop Sports Phys Ther 34:116-25. 2004
    ..Prospective randomized comparison of 2 rehabilitation programs...
  9. ncbi Balance as a predictor of ankle injuries in high school basketball players
    T A McGuine
    Athletic Training Program, University of Wisconsin Health Sports Medicine Center, Madison 53711, USA
    Clin J Sport Med 10:239-44. 2000
    ..Predicting risk for ankle injury could be important in helping to reduce the risk of these injuries and furthermore save health care costs...
  10. doi Occurrence of injuries and illnesses during the 2009 IAAF World Athletics Championships
    Juan Manuel Alonso
    International Association of Athletics Federations IAAF, Monaco
    Br J Sports Med 44:1100-5. 2010
    ..To analyse the frequency and characteristics of sports injuries and illnesses incurred during the World Athletics Championships...
  11. pmc Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal alpha-adrenoceptors
    Sung Tae Koo
    Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
    Pain 135:11-9. 2008
    ..These data suggest that the analgesic effect of EA in ankle sprain pain is, at least in part, mediated by spinal alpha(2)-adrenoceptor mechanisms...
  12. pmc The effect of lace-up ankle braces on injury rates in high school basketball players
    Timothy A McGuine
    UW Health Sports Medicine Center, Madison, WI 53711, USA
    Am J Sports Med 39:1840-8. 2011
    ..Ankle injuries are the most common injury in basketball players. However, no prospective studies have been performed to determine if wearing lace-up ankle braces will reduce the incidence of ankle injuries in high school athletes...
  13. pmc Effect of unsupervised home based proprioceptive training on recurrences of ankle sprain: randomised controlled trial
    Maarten D W Hupperets
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT, Amsterdam, Netherlands
    BMJ 339:b2684. 2009
    ..To evaluate the effectiveness of an unsupervised proprioceptive training programme on recurrences of ankle sprain after usual care in athletes who had sustained an acute sports related injury to the lateral ankle ligament...
  14. ncbi Immobilisation for acute ankle sprain. A systematic review
    G M Kerkhoffs
    University of Amsterdam, Academic Medical Center, Department of Orthopaedic Surgery, The Netherlands
    Arch Orthop Trauma Surg 121:462-71. 2001
    ..Concerning effectiveness, immobilisation, if necessary, should be restricted to certain patients and for short time periods...
  15. doi Injury risk of playing football in Futsal World Cups
    Astrid Junge
    Schulthess Klinik, FIFA Medical Assessment and Research Center, Fédération Internationale de Football Association, Lengghalde 2, Zurich, Switzerland
    Br J Sports Med 44:1089-92. 2010
    ..While injuries in football (soccer) have been the subject of numerous publications, little information is available about the injury risk in futsal...
  16. pmc What is the evidence for rest, ice, compression, and elevation therapy in the treatment of ankle sprains in adults?
    Michel P J van den Bekerom
    Academic Medical Centre, Department of Orthopaedic Surgery, Orthopaedic Research Center Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Athl Train 47:435-43. 2012
    ..The variation in treatment observed for the acutely injured lateral ankle ligament complex in the first week after the injury suggests a lack of evidence-based management strategies for this problem...
  17. pmc The effect of taping versus semi-rigid bracing on patient outcome and satisfaction in ankle sprains: a prospective, randomized controlled trial
    Sacha Lardenoye
    Department of Surgery, Division of Traumasurgery, Maastricht University Medical Center, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
    BMC Musculoskelet Disord 13:81. 2012
    ..A meta-analysis comparing the different functional treatment options could not make definitive conclusions regarding the effectiveness, and until now, little was known about patient satisfaction in relation to the outcome...
  18. pmc Determination of future prevention strategies in elite track and field: analysis of Daegu 2011 IAAF Championships injuries and illnesses surveillance
    Juan Manuel Alonso
    RFEA Servicios Médicos, Avenida de Valladolid, 81, 28008 Madrid, Spain
    Br J Sports Med 46:505-14. 2012
    ..To determine the incidence and characteristics of newly incurred injuries and illnesses during international Athletics Championships, by improving the medical surveillance coverage, in order to determine future prevention strategies...
  19. doi Comparison of magnetic resonance imaging to physical examination for syndesmotic injury after lateral ankle sprain
    Paulo Céesar de César
    Department of Orthopedy and Traumatology, Hospital Mãe de Deus de Porto Alegre, RS, Brazil
    Foot Ankle Int 32:1110-4. 2011
    ..This study sought to determine the sensitivity and specificity of both for syndesmotic injury secondary to lateral ankle sprain...
  20. doi Hindfoot joint pressure in supination sprains
    Fabian Krause
    Department of Orthopaedic Surgery, Inselspital, University of Berne, Berne, Switzerland
    Am J Sports Med 40:902-8. 2012
    ..Hindfoot trauma including ankle and subtalar sprains may be followed by osteochondral lesions and persisting pain originating from posttraumatic arthritis...
  21. pmc Clinical and cost effectiveness of mechanical support for severe ankle sprains: design of a randomised controlled trial in the emergency department [ISRCTN 37807450]
    S E Lamb
    Centre for Primary Health Care Studies, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK
    BMC Musculoskelet Disord 6:1. 2005
    ....
  22. doi Elastic stockings or Tubigrip for ankle sprain: a randomised clinical trial
    Muhammad J Sultan
    Academic Surgery Unit, University Hospital of South Manchester, Manchester M23 9LT, UK
    Injury 43:1079-83. 2012
    ..Ankle sprains are common and generally believed to be benign and self-limiting. However, a significant proportion of patients with ankle sprains have persistent symptoms for months or even years...
  23. ncbi Balance problems after unilateral lateral ankle sprains
    Mohammad Akbari
    Department of Physical Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, PO Box 15875 4391, Tehran, Iran
    J Rehabil Res Dev 43:819-24. 2006
    ..We can conclude that balance problems occur after acute ankle sprains because of proprioception deficits and that the unconscious (reflexive) aspect of proprioception is more severely affected than the conscious (voluntary) aspect...
  24. doi A systematic review on the treatment of acute ankle sprain: brace versus other functional treatment types
    Ellen Kemler
    Rudolf Magnus Institute of Neuroscience, Department of Rehabilitation, Nursing Science and Sport, University Medical Centre Utrecht, Utrecht, The Netherlands
    Sports Med 41:185-97. 2011
    ..Further research should focus on economic evaluation and on different types of ankle brace, to examine the strengths and weaknesses of ankle braces for the treatment of acute ankle sprains...
  25. doi Dynamic postural control but not mechanical stability differs among those with and without chronic ankle instability
    E A Wikstrom
    Biodynamics Research Laboratory, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Scand J Med Sci Sports 20:e137-44. 2010
    ..Mechanical stability alterations are speculated to result from the initial ankle trauma...
  26. ncbi Eccentric muscle strength in functional ankle instability
    Joanne Munn
    School of Physiotherapy, University of Sydney, Sydney, Australia
    Med Sci Sports Exerc 35:245-50. 2003
    ..To investigate muscle strength in subjects with unilateral functional ankle instability, with the specific aim of determining whether eccentric strength deficits exist...
  27. ncbi Sports-related muscle injury in the lower extremity
    Derek R Armfield
    Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Sports Med 25:803-42. 2006
  28. pmc Management of the sprained ankle
    C N van Dijk
    Academic Medical Centre, Amsterdam, The Netherlands
    Br J Sports Med 36:83-4. 2002
  29. ncbi Biomechanics of ankle instability. Part 1: Reaction time to simulated ankle sprain
    Andrew Mitchell
    University of Chichester, Chichester, West Sussex, United Kingdom
    Med Sci Sports Exerc 40:1515-21. 2008
    ..To test the hypothesis that ankles with functional instability will demonstrate slower muscular reaction times than their contralateral stable ankle (SA) and stable healthy controls to a simulated nonpathological ankle sprain mechanism...
  30. ncbi Ligamentous posttraumatic ankle osteoarthritis
    Victor Valderrabano
    Human Performance Laboratory and Orthopaedic Department, University of Calgary, 2500 University Drive N W, Calgary, Alberta, Canada, T2N 1N4
    Am J Sports Med 34:612-20. 2006
    ..Ankle sprains are the most common injuries in sports and recreational activities...
  31. pmc Management of ankle sprains: a randomised controlled trial of the treatment of inversion injuries using an elastic support bandage or an Aircast ankle brace
    S H Boyce
    A and E Department, Glasgow Victoria Infirmary, 33 Mansionhouse Gardens, Langside, Glasgow G41 3DP, Scotland, UK
    Br J Sports Med 39:91-6. 2005
    ..Lateral ligament ankle sprains are the single most common sports injury...
  32. pmc Lumbar spine region pathology and hamstring and calf injuries in athletes: is there a connection?
    J W Orchard
    University of Melbourne South Sydney Sports Medicine, Australia
    Br J Sports Med 38:502-4; discussion 502-4. 2004
    ....
  33. pmc An economic evaluation of a proprioceptive balance board training programme for the prevention of ankle sprains in volleyball
    E A L M Verhagen
    EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Sports Med 39:111-5. 2005
    ..To evaluate the cost effectiveness of a proprioceptive balance board training programme for the prevention of ankle sprains in volleyball...
  34. pmc Supervised exercises for adults with acute lateral ankle sprain: a randomised controlled trial
    Rogier M van Rijn
    Department of General Practice, Rotterdam, The Netherlands
    Br J Gen Pract 57:793-800. 2007
    ..During the recovery period after acute ankle sprain, it is unclear whether conventional treatment should be supported by supervised exercise...
  35. pmc Population based epidemiology of ankle sprains attending accident and emergency units in the West Midlands of England, and a survey of UK practice for severe ankle sprains
    S A Bridgman
    School of Medicine, Keele University, Stoke on Trent, UK
    Emerg Med J 20:508-10. 2003
    ..To estimate the incidence of ankle sprains and severe ankle sprains attending accident and emergency (A&E) units; to describe current practice for severe ankle sprains in A&E units in the United Kingdom...
  36. ncbi Postural control deficits in participants with functional ankle instability as measured by the balance error scoring system
    Carrie L Docherty
    Department of Kinesiology, Indiana University, Bloomington, IN 47408, USA
    Clin J Sport Med 16:203-8. 2006
    ..To determine if postural control deficits are present in participants with functional ankle instability (FAI) as measured by the Balance Error Scoring System (BESS)...
  37. ncbi Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study
    R Koll
    Merck Selbstmedikation GmbH, Roesslerstr 96, D 64293 Darmstadt, Germany
    Phytomedicine 11:470-7. 2004
    ..The good local and global tolerance of the trial medication could also be confirmed. The study results are consistent with the known pre-clinical and clinical data concerning comfrey...
  38. doi What is the clinical course of acute ankle sprains? A systematic literature review
    Rogier M van Rijn
    Department of General Practice, Erasmus MC, Rotterdam, The Netherlands
    Am J Med 121:324-331.e6. 2008
    ....
  39. doi Proximal hamstring strains of stretching type in different sports: injury situations, clinical and magnetic resonance imaging characteristics, and return to sport
    Carl M Askling
    Swedish School of Sport and Health Sciences, Stockholm, Sweden
    Am J Sports Med 36:1799-804. 2008
    ..Hamstring strains can be of at least 2 types, 1 occurring during high-speed running and the other during motions in which the hamstring muscles reach extreme lengths, as documented for sprinters and dancers...
  40. pmc Systematic review of postural control and lateral ankle instability, part II: is balance training clinically effective?
    Patrick O McKeon
    Division of Athletic Training, University of Kentucky, Lexington, KY 40536 0200, USA
    J Athl Train 43:305-15. 2008
    ..ankle sprain? (2) Can balance and coordination training improve treatment outcomes associated with acute ankle sprains? (3) Can balance and coordination training improve treatment outcomes in patients with chronic ankle instability?..
  41. doi Biomechanics of ankle instability. Part 2: Postural sway-reaction time relationship
    Andrew Mitchell
    University of Chichester, Chichester, West Sussex, United Kingdom
    Med Sci Sports Exerc 40:1522-8. 2008
    ....
  42. doi Posterior thigh muscle injuries in elite track and field athletes
    Nikolaos Malliaropoulos
    National Track and Field Centre, Sports Medicine Clinic S E G A S, Thessaloniki, Greece
    Am J Sports Med 38:1813-9. 2010
    ..Posterior thigh muscle injuries in athletes are common, and prediction of recovery time would be of value...
  43. ncbi Effect of isokinetic training on strength, functionality and proprioception in athletes with functional ankle instability
    Ufuk Sekir
    Department of Sports Medicine, Medical School of Uludag University, 16059 Gorukle, Bursa, Turkey
    Knee Surg Sports Traumatol Arthrosc 15:654-64. 2007
    ..These results substantiate the deficits of strength, proprioception, balance and functionality in recreational athletes with FAI. The isokinetic exercise program used in this study had a positive effect on these parameters...
  44. ncbi Management of ankle sprains
    M W Wolfe
    Lewis-Gale Clinic, Salem, Virginia, USA
    Am Fam Physician 63:93-104. 2001
    ..Sprains with complete ligament [corrected] tears (grade III) may require surgical intervention. Although early motion and mobility are recommended, ligamentous strength does not return until months after an ankle sprain...
  45. pmc Clinical risk factors for hamstring muscle strain injury: a prospective study with correlation of injury by magnetic resonance imaging
    G M Verrall
    SPORTSMED SA Sports Medicine Clinic, Adelaide, Australia
    Br J Sports Med 35:435-9; discussion 440. 2001
    ..To prospectively establish risk factors for hamstring muscle strain injury using magnetic resonance imaging (MRI) to define the diagnosis of posterior thigh injury...
  46. ncbi Intrinsic and extrinsic risk factors for muscle strains in Australian football
    J W Orchard
    Sports Medicine Unit, University of New South Wales, Sydney, Australia
    Am J Sports Med 29:300-3. 2001
    ..Quadriceps muscle injuries were significantly more common in the dominant kicking leg, whereas hamstring and calf muscle injuries showed no difference in frequency between the dominant and nondominant legs...
  47. doi Effect of accelerated rehabilitation on function after ankle sprain: randomised controlled trial
    Chris M Bleakley
    Health and Rehabilitation Sciences Research Institute, School of Health Sciences, University of Ulster, Jordanstown, Newtownabbey, Co Antrim BT37 0QB
    BMJ 340:c1964. 2010
    ..To compare an accelerated intervention incorporating early therapeutic exercise after acute ankle sprains with a standard protection, rest, ice, compression, and elevation intervention...
  48. ncbi A prospective, randomized clinical investigation of the treatment of first-time ankle sprains
    Bruce D Beynnon
    Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, University of Vermont, Burlington, VT 05405 0084, USA
    Am J Sports Med 34:1401-12. 2006
    ....
  49. doi Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries
    Koichi Nakazato
    Department of Exercise Physiology, Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan
    Mol Nutr Food Res 54:364-72. 2010
    ..The APP group had significantly higher glutathione-S-transferase alpha1 mRNA levels than the CON group. Therefore, we conclude that dietary APPs have protective effects against lengthening contraction-induced muscle injury...
  50. ncbi Acute treatment of inversion ankle sprains: immobilization versus functional treatment
    Morgan H Jones
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Orthop Relat Res 455:169-72. 2007
    ..However, based on our review the current best evidence suggests a trend favoring early functional treatment over immobilization for the treatment of acute lateral ankle sprains...
  51. ncbi Comparison of conventional treatment and supervised rehabilitation for treatment of acute lateral ankle sprains: a systematic review of the literature
    Anton G van Os
    Department of General Practice, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Orthop Sports Phys Ther 35:95-105. 2005
    ..Systematic literature review...
  52. doi Reinjury after acute lateral ankle sprains in elite track and field athletes
    Nikolaos Malliaropoulos
    National Track and Field Centre, Sports Injury Clinic, Sports Medicine Clinic of S E G A S, Thessaloniki, Greece
    Am J Sports Med 37:1755-61. 2009
    ..Lateral ankle sprains can lead to persistent disability in athletes. The authors studied the effect of a lateral ankle sprain on reinjury occurrence in the same region...
  53. pmc Spatiotemporal postural control deficits are present in those with chronic ankle instability
    Patrick O McKeon
    Department of Rehabilitation Sciences, University of Kentucky, Lexington, Kentucky, USA
    BMC Musculoskelet Disord 9:76. 2008
    ..In a previous study, TTB deficits were detected in a sample of females with CAI. The purpose of this study was to examine postural control in sample of males and females with and without CAI using TTB measures...
  54. doi Effects of a 4-week exercise program on balance using elastic tubing as a perturbation force for individuals with a history of ankle sprains
    Kyungmo Han
    Department of Kinesiology, San Jose State University, San Jose, CA 95192 0054, USA
    J Orthop Sports Phys Ther 39:246-55. 2009
    ..Randomized controlled trial with pretraining, posttraining, and follow-up repeated measures...
  55. ncbi Hip and groin injuries in athletes
    K Anderson
    Center for Athletic Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA
    Am J Sports Med 29:521-33. 2001
    ..This article briefly reviews several common hip and groin conditions affecting athletic patients and highlights some newer topics...
  56. ncbi Treatment of lateral ankle instability with transfer of the extensor digitorum brevis muscle
    Nils E Westlin
    J Foot Ankle Surg 42:183-92. 2003
    ..Thus, the extensor digitorum brevis muscle transfer seems to be a useful alternative method of long-term ankle stabilization in these difficult chronic case; the results correlate well with a few other studies using this method...
  57. ncbi The effect of a 4-week comprehensive rehabilitation program on postural control and lower extremity function in individuals with chronic ankle instability
    Sheri A Hale
    Shenandoah University, Division of Physical Therapy, Winchester, VA 22601, USA
    J Orthop Sports Phys Ther 37:303-11. 2007
    ..Prospective, randomized controlled trial...
  58. ncbi Effects of ankle sprain in a general clinic population 6 to 18 months after medical evaluation
    B L Braun
    Division of Education and Research, St Mary s Duluth Clinic Health System, Minn, USA
    Arch Fam Med 8:143-8. 1999
    ..To assess the 1-year outcome of standard medical care of acute ankle sprains in a general clinic-based population...
  59. pmc A survey of flexibility training protocols and hamstring strains in professional football clubs in England
    B Dadebo
    Department of Exercise and Sport Sciences, Manchester Metropolitan University, Crewe and Alsager Faculty, Hassal Road, Alsager ST7 2HL, UK
    Br J Sports Med 38:388-94. 2004
    ..To investigate the relation between current flexibility training protocols, including stretching, and hamstring strain rates (HSRs) in English professional football clubs...
  60. ncbi Intrinsic risk factors for inversion ankle sprains in male subjects: a prospective study
    Tine Marieke Willems
    Department of Rehabilitation Sciences and Physiotherapy, Ghent University, University Hospital, De Pintelaan 185, 6K3, 9000 Ghent, Belgium
    Am J Sports Med 33:415-23. 2005
    ..Many variables have been retrospectively associated with ankle sprains. However, very little is known about factors predisposing people to these injuries...
  61. ncbi Practical management: nonsteroidal antiinflammatory drug (NSAID) use in athletic injuries
    Christopher J Mehallo
    McShane Sports Medicine, 1098 West Baltimore Pike, Suite 3308, Media, PA 19063, and Department of Family Medicine, Hall Health Center Sports Medicine, University of Washington, Box 354775, Seattle, WA 98105, USA
    Clin J Sport Med 16:170-4. 2006
    ..However, length of treatment should always be kept as short as possible, with consideration of the specific type of injury, level of dysfunction, and pain...
  62. ncbi A twofold reduction in the incidence of acute ankle sprains in volleyball after the introduction of an injury prevention program: a prospective cohort study
    R Bahr
    Norwegian University of Sport and Physical Education, Oslo, Norway
    Scand J Med Sci Sports 7:172-7. 1997
    ..9 +/- 0.1 per 1000 player hours during the 1992-93 season (48 injuries) to 0.7 +/- 0.1 during the 1993-94 season (38 injuries; NS vs. 1992-93) and to 0.5 +/- 0.1 during the 1994-95 season (24 injuries, P < 0.01 vs. 1992-93)...
  63. ncbi The role of stretching in rehabilitation of hamstring injuries: 80 athletes follow-up
    Nikos Malliaropoulos
    Sports Medicine Clinic of S E G A S, Thessaloniki, Greece
    Med Sci Sports Exerc 36:756-9. 2004
    ..The increased joint range of motion (ROM), indicating the degree of muscle flexibility, has a benefit of stretching proven for healthy tissues...
  64. ncbi Examination of static and dynamic postural stability in individuals with functionally stable and unstable ankles
    Scott E Ross
    Department of Exercise Science, Virginia Commonwealth University, Richmond, VA 23284, USA
    Clin J Sport Med 14:332-8. 2004
    ..To determine static and dynamic postural stability differences between functional ankle instability and stable ankle groups...
  65. pmc Cryotherapy for acute ankle sprains: a randomised controlled study of two different icing protocols
    C M Bleakley
    Health and Rehabilitation Sciences Research Institute, University of Ulster, Jordanstown BT37 0QB, County Antrim, Northern Ireland, UK
    Br J Sports Med 40:700-5; discussion 705. 2006
    ..Preliminary evidence suggests that intermittent cryotherapy applications are most effective at reducing tissue temperature to optimal therapeutic levels. However, its efficacy in treating injured human subjects is not yet known...
  66. ncbi Efficacy of celecoxib, a COX-2-specific inhibitor, and naproxen in the management of acute ankle sprain: results of a double-blind, randomized controlled trial
    Robert Petrella
    Canadian Center for Activity and Aging, London, Ontario, Canada
    Clin J Sport Med 14:225-31. 2004
    ..To assess the efficacy and safety of celecoxib and naproxen in the treatment of acute ankle sprain...
  67. ncbi Effectiveness of exercise therapy and manual mobilisation in ankle sprain and functional instability: a systematic review
    Philip J van der Wees
    Department of Epidemiology, Maastricht University, The Netherlands
    Aust J Physiother 52:27-37. 2006
    ..Manual mobilisation has an (initial) effect on dorsiflexion range of motion, but the clinical relevance of these findings for physiotherapy practice may be limited...
  68. ncbi Contributing factors to chronic ankle instability
    Tricia J Hubbard
    Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Foot Ankle Int 28:343-54. 2007
    ..There is no clear indication of which measures are most important in discriminating between individuals with and without CAI...
  69. pmc Do voluntary strength, proprioception, range of motion, or postural sway predict occurrence of lateral ankle sprain?
    M de Noronha
    School of Physiotherapy, University of Sydney, PO Box 170, Lidcombe, NSW 1825, Australia
    Br J Sports Med 40:824-8; discussion 828. 2006
    ..Postural sway and possibly proprioception were also predictors. Therefore the preliminary evidence suggests that people with reduced ankle dorsiflexion range may be at increased risk of ankle sprain...
  70. ncbi Risk factors for noncontact ankle sprains in high school football players: the role of previous ankle sprains and body mass index
    Timothy F Tyler
    Nicholas Institute of Sports Medicine and Athletic Trauma, Lenox Hill Hospital, 130 East 77th Street, New York, NY 10021, USA
    Am J Sports Med 34:471-5. 2006
    ..In a previous study, we noted a possible connection between an athlete's weight and risk of ankle sprain...
  71. ncbi Acupuncture analgesia in a new rat model of ankle sprain pain
    Sung Tae Koo
    Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Pain 99:423-31. 2002
    ..The present study provides a powerful experimental animal model that can be used for investigating the unique physiological mechanisms involved in acupuncture analgesia...
  72. ncbi Some benefit from physiotherapy intervention in the subgroup of patients with severe ankle sprain as determined by the ankle function score: a randomised trial
    Rogier M van Rijn
    Department of General Practice, Erasmus MC, Rotterdam, The Netherlands
    Aust J Physiother 55:107-13. 2009
    ..a mild injury (score > 40)? Does physiotherapy intervention have more effect on patients with a severe injury compared with a mild injury in the short- or long-term? Is self-reported recovery related to ankle function score over time?..
  73. ncbi Acute ankle sprain: an update
    Douglas Ivins
    Department of Family Medicine, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74102, USA
    Am Fam Physician 74:1714-20. 2006
    ..Ankle disk or proprioceptive neuromuscular facilitation exercise regimens also may be helpful, although the literature supporting this is limited...
  74. ncbi Incidence of injury in elite Gaelic footballers
    M Newell
    University of Glasgow, Institute of Biomedical and Life Sciences, Glasgow
    Ir Med J 99:269-71. 2006
    ..The high incidence of injury especially hamstrings injuries in the latter stages of training and games warrants further investigation...
  75. ncbi The efficacy of adjusting the ankle in the treatment of subacute and chronic grade I and grade II ankle inversion sprains
    J E Pellow
    Technikon Natal, Chiropractic Department, Durban, South Africa
    J Manipulative Physiol Ther 24:17-24. 2001
    ..The purpose of this study was to determine the efficacy of adjusting the ankle in the treatment of subacute and chronic grade I and grade II ankle inversion sprains...
  76. pmc Evidence based prevention of hamstring injuries in sport
    J Petersen
    Department of Orthopaedic Surgery, Amager University Hospital, Copenhagen, Denmark
    Br J Sports Med 39:319-23. 2005
    ..As the injuries are common in football and other sports involving sprinting and jumping, there is a need for further research preferably in the form of randomised controlled trials...
  77. ncbi Functional instability following lateral ankle sprain
    J Hertel
    Department of Kinesiology, Pennsylvania State University, University Park, USA
    Sports Med 29:361-71. 2000
    ..The treatment and rehabilitation goals must also address restoration of neuromuscular function, as well as restoration of mechanical stability to the injured joints...
  78. ncbi Lateral ankle sprains: a comprehensive review: part 1: etiology, pathoanatomy, histopathogenesis, and diagnosis
    M R Safran
    Department of Orthopaedic Surgery, Kaiser Permanente, Orange County, Anaheim, CA 92804, USA
    Med Sci Sports Exerc 31:S429-37. 1999
    ..This will also serve as the foundation for part two of our study, which is to understand the rationale for our treatment approach for this common problem...
  79. ncbi The relationship between self-reported and clinical measures and the number of days to return to sport following acute lateral ankle sprains
    Kevin M Cross
    University of Virginia, Charlottesville, USA
    J Orthop Sports Phys Ther 32:16-23. 2002
    ..This is a prospective observational study...
  80. ncbi Prevention of hamstring strains in elite soccer: an intervention study
    A Arnason
    Oslo Sports Trauma Research Center, Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
    Scand J Med Sci Sports 18:40-8. 2008
    ..These results should be verified in randomized clinical trials...
  81. pmc Long term outcomes of inversion ankle injuries
    A Anandacoomarasamy
    Department of Rheumatology, Concord Hospital, Hospital Road, Concord, NSW 2139, Australia
    Br J Sports Med 39:e14; discussion e14. 2005
    ..Ankle sprains are common sporting injuries generally believed to be benign and self limiting. However, some studies report a significant proportion of patients with ankle sprains having persistent symptoms for months or even years...
  82. ncbi The effect of a balance training program on the risk of ankle sprains in high school athletes
    Timothy A McGuine
    University of Wisconsin, Hospital and Clinics, Sports Medicine Center, Madison, Wisconsin, USA
    Am J Sports Med 34:1103-11. 2006
    ..Ankle sprains are the most common musculoskeletal injuries that occur in athletes, and they have a profound impact on health care costs and resources...
  83. ncbi Lateral ankle sprain: isokinetic test reliability and comparison between invertors and evertors
    Marcos Amaral De Noronha
    Universidade do Estado de Santa Catarina, Santa Catarina 2047, Brazil
    Clin Biomech (Bristol, Avon) 19:868-71. 2004
    ..Evaluate reliability of isokinetic tests for inversion and eversion in individuals with recurrent lateral ankle sprain and compare inversion to eversion muscle performance in the same ankles...
  84. doi UEFA injury study--an injury audit of European Championships 2006 to 2008
    M Hägglund
    Department of Medical and Health Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Br J Sports Med 43:483-9. 2009
    ..To study the incidence and nature of injuries at European Championships, to compare training and match injury characteristics and to study differences in injury incidence between tournaments...
  85. ncbi Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain
    Evan F Ekman
    Southern Orthopaedic Sports Medicine, Providence Hospital Columbia, South Carolina, USA
    Am J Orthop (Belle Mead NJ) 31:445-51. 2002
    ..Celecoxib, a cyclo-oxygenase-2-specific inhibitor with platelet-function-sparing properties, may be useful as a multimodal adjuvant in the treatment of ankle sprain...
  86. doi Anterior cruciate ligament injury in elite football: a prospective three-cohort study
    Markus Waldén
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:11-9. 2011
    ..These findings suggest that future preventive research primarily should address the young female football player...
  87. doi Peroneal activation deficits in persons with functional ankle instability
    Riann M Palmieri-Smith
    School of Kinesiology, University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    Am J Sports Med 37:982-8. 2009
    ..This activation deficit, referred to as arthrogenic muscle inhibition (AMI), may be the underlying cause of FAI. Incomplete activation could prevent adequate control of the ankle joint, leading to repeated episodes of instability...
  88. pmc A one season prospective cohort study of volleyball injuries
    E A L M Verhagen
    Institute for Research in Extramural Medicine and TNO Vumc, Amsterdam, Netherlands
    Br J Sports Med 38:477-81. 2004
    ..To estimate the overall incidence of acute and overuse volleyball injuries, and to describe factors associated with ankle sprains...
  89. ncbi Effect of increased excursion of the ankle on the severity of acute eccentric contraction-induced strain injury in the gastrocnemius: an in vivo rat study
    Hongsun Song
    Nippon Sport Science University, Fukasawa, Tokyo, Japan
    Am J Sports Med 32:1263-9. 2004
    ..In this study, a minimally invasive model of acute strain injury was produced with a single eccentric contraction...
  90. ncbi Possible factors related to functional ankle instability
    Marcio J Santos
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS, USA
    J Orthop Sports Phys Ther 38:150-7. 2008
    ..Case control study...
  91. ncbi Ankle sprain injuries and risk factors in amateur soccer players during a 2-year period
    Nikolaos D Kofotolis
    Laboratory of Neuromuscular Control and Therapeutic Exercise, Department of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, Greece
    Am J Sports Med 35:458-66. 2007
    ..Although ankle sprains are common in soccer, the role of various risk factors in amateur soccer players is unclear...
  92. pmc Effectiveness of additional supervised exercises compared with conventional treatment alone in patients with acute lateral ankle sprains: systematic review
    Rogier M van Rijn
    Department of General Practice, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA Rotterdam, Rotterdam, Netherlands
    BMJ 341:c5688. 2010
    ..To summarise the effectiveness of adding supervised exercises to conventional treatment compared with conventional treatment alone in patients with acute lateral ankle sprains...
  93. ncbi [Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine]
    Marie Solignac
    Presse Med 33:3S10-3. 2004
    ..VARIOUS CLINICAL TRIALS: Have shown that the Flector Plaster is well tolerated and effective in the treatment of epicondylitis, sprained ankles, minor sport-induced trauma and osteo-arthrosis of the knee...
  94. doi Vibration training improves balance in unstable ankles
    R Cloak
    The University of Wolverhampton, School of Sport, Performing Arts and Leisure, Walsall, United Kingdom
    Int J Sports Med 31:894-900. 2010
    ..915) in either group. WBVT improved static balance and SEBT scores amongst dancers exhibiting ankle instability but did not affect peroneus longus muscle fatigue...
  95. doi Predicting short-term response to thrust and nonthrust manipulation and exercise in patients post inversion ankle sprain
    Julie M Whitman
    Evidence in Mothion, Louisville, KY, USA
    J Orthop Sports Phys Ther 39:188-200. 2009
    ..Prospective-cohort/predictive-validity study...
  96. doi Functional treatment after surgical repair for acute lateral ligament disruption of the ankle in athletes
    Masato Takao
    Department of Orthopaedic Surgery, Teikyo University, Tokyo, Japan
    Am J Sports Med 40:447-51. 2012
    ..There have been several reports showing 20% to 40% failure after nonoperative functional treatment for acute lateral ligament disruption of the ankle...
  97. ncbi The effect of lateral ankle sprain on dorsiflexion range of motion, posterior talar glide, and joint laxity
    Craig R Denegar
    Department of Kinesiology and Orthopaedics and Rehabilitation, The Pennsylvania State University, University Park 16802, USA
    J Orthop Sports Phys Ther 32:166-73. 2002
    ..Retrospective study...
  98. ncbi A multi-station proprioceptive exercise program in patients with ankle instability
    E Eils
    Funktionsbereich Bewegungsanalytik Movement Analysis Lab, Klinik und Poliklinik fuer Allgemeine Orthopaedie, Westfaelische Wilhelms Universitaet Muenster, Domagkstrasse 3, D 48129 Muenster, Germany
    Med Sci Sports Exerc 33:1991-8. 2001
    ..The aim of the present study was to investigate the effects of a 6-wk multi-station proprioceptive exercise program that is easy to integrate in normal training programs...
  99. ncbi A systematic review on ankle injury and ankle sprain in sports
    Daniel Tik Pui Fong
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Sports Med 37:73-94. 2007
    ..The incidence of ankle injury and ankle sprain was high in court games and team sports, such as rugby, soccer, volleyball, handball and basketball. This systematic review provides a summary of the epidemiology of ankle injury in sports...
  100. ncbi High-intensity training with a bi-directional bicycle pedal improves performance in mechanically unstable ankles--a prospective randomized study of 19 subjects
    Per Høiness
    Orthopaedic Surgical Department, Ullevaal University Hospital, N 0407 Oslo, Norway
    Scand J Med Sci Sports 13:266-71. 2003
    ..018), but otherwise no significant effects were found. This study indicates that short-term high-intensity training with a bi-directional pedal improves ankle performance and may be an option in the treatment of recurrent ankle sprains...
  101. pmc A survey of current consultant practice of treatment of severe ankle sprains in emergency departments in the United Kingdom
    M W Cooke
    Centre for Primary Health Care Studies, University of Warwick, UK
    Emerg Med J 20:505-7. 2003
    ..To determine current consultant practice in larger UK emergency departments in the management of severe ankle sprains...

Research Grants76

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor is responsible for providing staff with the credentials required by CLIA. ..
  4. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..We propose these humanized mice will be a technology platform to better understand the human disease and it will aid in the development of gene or cellular therapy to correct these devastating diseases. ..
  5. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..In addition to human plasma and human plasma proteins such as fibrinogen, the developed technology will also be applicable to recombinant therapeutics, monoclonal antibodies, transgenics and vaccines. ..
  6. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
  7. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ....
  8. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ....
  9. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  10. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..Additionally, insight will be gained into the regulation of T cell function in both health and disease with relevance to an array of immune and neoplastic diseases. ..
  11. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ....
  12. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  13. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..Given the shortcomings of available measures to successfully control this infection, and its bioterrorism potential, to develop a S. dysenteriae type 1 vaccine is of great importance. ..
  14. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..aeruginosa, A. baumannii and K. pneumoniae. Overall, this project targets the urgent global unmet medical need and responds in a timely manner to the recent global call for discovery of new antibiotics: The 10 x '20 Initiative. ..
  15. The role of IKK beta in cardiomyocytes at baseline and following stress
    MATTHEW PETER COGGINS; Fiscal Year: 2013
    ..abstract_text> ..
  16. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..abstract_text> ..
  17. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..Immune signaling and effector pathways will be examined to define clearance mechanisms that H. influenzae is able to avoid by modulating its surface structures. ..
  18. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..We will also develop a RASV using S. Typhi as vector to prevent transmission and infection by Mycobacterium tuberculosis. ..
  19. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ....
  20. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    ..cholerae detachment and the role of protease production and motility in this process. These studies could open new avenues to treat cholera and shed light on the epidemic potential of this pathogen. ..
  21. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ....
  22. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..Ultimately, these studies will identify novel molecular targets in the actions of ethanol and ethanol drinking behavior, and promote the development of pharmacotherapy for alcoholism. ..
  23. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..difficile infection, reduce the severity, or eliminate an ongoing chronic disease. ..
  24. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..If successful, this vaccine(s) should have a societal public health benefit of a magnitude similar to the impact of the smallpox vaccine. ..
  25. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..The "bioconjugate" vaccines will be tested in animal models of staphylococcal infection and processed for initial safety testing in humans. ..
  26. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..These studies will have a major impact on our understanding of H. pylori immunopathogenesis and gastric carcinogenesis, and will lead to new approaches for risk assessment and treatment. ..
  27. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..We propose to reduce the size of these regions in the mouse genome, which cannot be done in human population, and select candidate genes that may be involved in arthritis susceptibility and disease severity. ..
  28. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  29. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..Improved treatment options, in this case the use of sodium nitrite for the management of COPD exacerbations precipitated by PA infection are needed to reduce mortality and morbidity. ..
  30. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..Patients with learning disorders and those suffering from complications due to neurodegenerative diseases will greatly benefit as PWZ-029 moves another step closer to the clinic. ..
  31. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
  32. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ....
  33. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ....
  34. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..abstract_text> ..
  35. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ....
  36. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..We seek to determine how common MRSA colonization and infection are in Iowa livestock, and to determine if livestock exposure represents a new occupational risk factor for MRSA colonization and infection. ..
  37. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..There is a compelling need for an abundant and accessible supply of animals to screen for new therapeutic agents. Thus, if successful, this project would benefit many goals of public health. ..
  38. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2012
    ....
  39. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..This new strategy would overcome the resistance to traditional antibiotics of microorganisms in biofilms. ..
  40. P38 MAP KINASE SIGNALING IN SKIN
    Tatiana Efimova; Fiscal Year: 2013
    ..We are optimistic that the completion of the proposed studies will result in a better mechanistic understanding of the p384 role in epithelial carcinogenesis and its potential as an anti-cancer therapeutic target. ..
  41. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..Finally, after completing a 10-generation backcross onto C57Bl/6, we will examine the mice for abnormalities in central nervous system by testing motor function, anxiety, learning, memory and by examining the brains neuropathologically. ..
  42. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ....
  43. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: The long-term goal of this proposal is the diagnosis and treatment of bacterial-induced ear infections. These infections are the most common illnesses in infants and young children. ..
  44. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..Potential clients include academic research labs as well as industrial labs interested in behavioral monitoring on a large scale (e.g. drug screening), and upgrades to existing users. ..
  45. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ....
  46. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ....
  47. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ....
  48. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    ....
  49. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..Dean and Shafer, and the microfluidic and molecular biology expertise of Dr. Selden, the application provides a unique collaborative opportunity to finally obtain a rapid point-of-care diagnostic for GC. ..
  50. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    ..g. military bases, hospitals or nursing homes). The number of typhoid fever cases exceeds 33 million per year worldwide and remains a potential concern among previously vaccinated travelers and military personnel. ..
  51. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..abstract_text> ..
  52. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..abstract_text> ..
  53. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..In Phase II, we will examine analogs of the highest priority hits and chemically optimize the most promising of these structures to develop lead compounds for efficacy and toxicity testing in animal models. ..
  54. NOX1 and NOX2 as Therapeutic Targets in Influenza
    JOHN DAVID LAMBETH; Fiscal Year: 2013
    ....
  55. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ....
  56. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..Second, lead generation for drugs that can be developed to interfere with biofilms and virulence of important pathogenic bacteria will be developed. ..
  57. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Influenza infection kills over 35,000 people in the United States each year. These studies will provide new information to enhance our ability to improve the influenza vaccines. ..
  58. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..This program will help the Candidate to train and develop scientists interested in drug development in academic settings. These efforts in the long term will help us to develop specific drugs for inflammatory diseases. ..
  59. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..Network Biosystems aims to develop an easy to use, cost effective, one hour diagnostic for C. trachomatis that also differentiates strains types for appropriate treatment. ..
  60. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ....
  61. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..These new drugs will not be susceptible to existing resistance mechanisms and will provide a proof of principle for the efficacy of this therapeutic approach. ..
  62. Mechanism of Translation Elongation Factor 2 Inhibition by Bacterial Toxins
    Terri Goss Kinzy; Fiscal Year: 2010
    ....
  63. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  64. Human cytomegalovirus entry into epithelial and endothelial cells
    David C Johnson; Fiscal Year: 2013
    ..Our studies will provide a better picture of how HCMV gains entry into biologically relevant epithelial and endothelial cells to facilitate the design of better anti-HCMV drugs and vaccines. ..
  65. Inhibitors of S. aureus bNOS for adjunctive therapy
    Donald T Moir; Fiscal Year: 2013
    ..These new drugs will prolong the duration of effective concentrations of existing antibiotics, thus reducing selection for resistance and improving therapy. ..
  66. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    ..Finally, we will share our results with public health organizations and the scientific community in a timely fashion in order to maximize the public good. ..
  67. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..This specific aim will depend upon a large genetic linkage study in human SLE currently being performed by Dr. Harley, and which already contains 30 pedigrees with a second cohort of an additional 30 pedigrees planned. ..
  68. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..aureus skin infections is increasing and hospital- and community-acquired infections caused by methicillin-resistant S. aureus (MRSA) and multi-drug resistant strains have emerged as major public health threats in the United States. ..
  69. Development of a Chloroquine Replacement Drug
    MICHAEL KEVIN RISCOE; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This application addresses broad Challenge Area (15) Translation Science and Specific Challenge Topic, 15-AI-103* Develop drugs for neglected tropical diseases, with a special emphasis on malaria. ..
  70. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..coli, the genetically susceptible individual's ability to process these organisms, and subsequent metabolic pathways involved in disease pathogenesis. ..
  71. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ....
  72. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..There are genes in CA-MRSA involved in this oxacillin sensitivity upon deletion of the pbp4 gene. Our goal is to identify and characterize these genes that confer oxacillin sensitivity. ..
  73. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  74. The effect of pncA expression and POA efflux rate in the level of PZA-resistance
    Mirko J Zimic; Fiscal Year: 2010
    ..Also, in this study we will carry out studies to characterize POA efflux pump-mediated PZA resistance in M. tuberculosis by using M. smegmatis as the model organism. ..
  75. AIDS ASSOCIATED LEUKOPLAKIA--ROLE OF EBV
    Nancy Raab Traub; Fiscal Year: 2004
    ..abstract_text> ..
  76. Mechanisms of non-neutralizing antibody-mediated protection from influenza virus
    DENISE KAMINSKI; Fiscal Year: 2009
    ....