rupture

Summary

Summary: Forcible or traumatic tear or break of an organ or other soft part of the body.

Top Publications

  1. ncbi Cumulative incidence of achilles tendon rupture and tendinopathy in male former elite athletes
    Urho M Kujala
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    Clin J Sport Med 15:133-5. 2005
  2. ncbi Randomised controlled trials of immediate weight-bearing mobilisation for rupture of the tendo Achillis
    M L Costa
    School of Medicine, The University of East Anglia, Norwich NR4 7TJ, Norfolk, UK
    J Bone Joint Surg Br 88:69-77. 2006
  3. ncbi Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture
    Andrew C Newby
    Bristol Heart Institute, University of Bristol, United Kingdom
    Physiol Rev 85:1-31. 2005
  4. ncbi Preventing heart injury during negative pressure wound therapy in cardiac surgery: assessment using real-time magnetic resonance imaging
    Malin Malmsjo
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 138:712-7. 2009
  5. ncbi Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques
    Atilla Yilmaz
    Medical Clinic II, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Atherosclerosis 176:101-10. 2004
  6. ncbi Flexor tendon injuries following locked volar plating of distal radius fractures
    Andrew W Cross
    Allegheny Hand Center, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Hand Surg Am 33:164-7. 2008
  7. ncbi Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice
    Helen Williams
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, United Kingdom
    Arterioscler Thromb Vasc Biol 22:788-92. 2002
  8. ncbi Prevalence and risk factors for anal incontinence after obstetric anal sphincter rupture
    Katariina Laine
    Department of Obstetrics and Department of Gynecology, Faculty of Medicine, Oslo University Hospital Ulleval, University of Oslo, Oslo, Norway
    Acta Obstet Gynecol Scand 90:319-24. 2011
  9. ncbi Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study
    B Pasternak
    Orthopaedics and Sports Medicine, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Br J Sports Med 44:669-72. 2010
  10. ncbi Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor
    Ali Moshiri
    Veterinary Surgery and Radiology, Department of Surgery and Radiology, Shiraz University School of Veterinary Medicine, Shiraz, Iran
    J Foot Ankle Surg 50:654-62. 2011

Research Grants

Detail Information

Publications351 found, 100 shown here

  1. ncbi Cumulative incidence of achilles tendon rupture and tendinopathy in male former elite athletes
    Urho M Kujala
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    Clin J Sport Med 15:133-5. 2005
    To study the cumulative incidence of Achilles tendon rupture and tendinopathy among former top-level athletes.
  2. ncbi Randomised controlled trials of immediate weight-bearing mobilisation for rupture of the tendo Achillis
    M L Costa
    School of Medicine, The University of East Anglia, Norwich NR4 7TJ, Norfolk, UK
    J Bone Joint Surg Br 88:69-77. 2006
    ..controlled trials in order to assess the potential benefits of immediate weight-bearing mobilisation after rupture of the tendo Achillis...
  3. ncbi Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture
    Andrew C Newby
    Bristol Heart Institute, University of Bristol, United Kingdom
    Physiol Rev 85:1-31. 2005
    ..Plaque rupture represents a failure of intimal remodeling, where the fibrous cap overlying an atheromatous core of lipid ..
  4. ncbi Preventing heart injury during negative pressure wound therapy in cardiac surgery: assessment using real-time magnetic resonance imaging
    Malin Malmsjo
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 138:712-7. 2009
    Heart rupture is a devastating complication to negative pressure wound therapy in cardiac surgery. Also, reduced cardiac output during negative pressure wound therapy has been reported...
  5. ncbi Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques
    Atilla Yilmaz
    Medical Clinic II, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Atherosclerosis 176:101-10. 2004
    ..02). DC clusters with a strong HLA-DR expression and frequent DC-T cell contacts were located particularly in the rupture-prone plaque regions and at complications...
  6. ncbi Flexor tendon injuries following locked volar plating of distal radius fractures
    Andrew W Cross
    Allegheny Hand Center, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Hand Surg Am 33:164-7. 2008
    ..We suggest close follow-up of all fractures in which the distal end of the plate is anterior to the radial rim and removal of hardware if symptoms suggest tendon irritation...
  7. ncbi Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice
    Helen Williams
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, United Kingdom
    Arterioscler Thromb Vasc Biol 22:788-92. 2002
    The brachiocephalic arteries of fat-fed apolipoprotein E knockout mice develop plaques that frequently rupture and form luminal thromboses...
  8. ncbi Prevalence and risk factors for anal incontinence after obstetric anal sphincter rupture
    Katariina Laine
    Department of Obstetrics and Department of Gynecology, Faculty of Medicine, Oslo University Hospital Ulleval, University of Oslo, Oslo, Norway
    Acta Obstet Gynecol Scand 90:319-24. 2011
    To study prevalence and risk factors for anal incontinence (AI) after obstetric anal sphincter rupture.
  9. ncbi Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study
    B Pasternak
    Orthopaedics and Sports Medicine, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Br J Sports Med 44:669-72. 2010
    ..MMPs) and tissue inhibitors of metalloproteinases (TIMPs) between patients with a history of Achilles tendon rupture and blood donor controls were compared, and their relation to mechanical properties of the tendons during healing ..
  10. ncbi Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor
    Ali Moshiri
    Veterinary Surgery and Radiology, Department of Surgery and Radiology, Shiraz University School of Veterinary Medicine, Shiraz, Iran
    J Foot Ankle Surg 50:654-62. 2011
    ..of basic fibroblast growth factor on the healing of the acute phase of complete superficial digital flexor tendon rupture in rabbits...
  11. pmc Terminology and classification of muscle injuries in sport: the Munich consensus statement
    Hans Wilhelm Mueller-Wohlfahrt
    MW Center of Orthopedics and Sports Medicine, Munich and Football Club FC Bayern Munich, Munich, Germany
    Br J Sports Med 47:342-50. 2013
    ..To provide a clear terminology and classification of muscle injuries in order to facilitate effective communication among medical practitioners and development of systematic treatment strategies...
  12. pmc Measurement of functional recovery in individuals with acute anterior cruciate ligament rupture
    K Button
    Department of Physiotherapy, Cardiff University, Cardiff, UK
    Br J Sports Med 39:866-71; discussion 866-71. 2005
    To measure functional recovery following acute anterior cruciate ligament (ACL) rupture using a simple and reliable clinical movement analysis system...
  13. pmc Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study
    Markus Tremmel
    Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA
    Neurosurgery 64:622-30; discussion 630-1. 2009
    The effectiveness of intracranial aneurysm (IA) size as a predictor for rupture has been debated...
  14. ncbi Single-row versus double-row arthroscopic rotator cuff repair: a prospective randomized clinical study
    Andrea Grasso
    Villa Valeria Clinic, Rome, Italy
    Arthroscopy 25:4-12. 2009
    ..The purpose of this study was to compare the clinical outcome of arthroscopic rotator cuff repair with single-row and double-row techniques...
  15. ncbi Pulmonary artery rupture induced by a pulmonary artery catheter: a case report and review of the literature
    Alexandre R Abreu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    J Intensive Care Med 19:291-6. 2004
    ..The authors describe a case of a patient who developed massive hemoptysis after placement of a PAC that caused a rupture of the pulmonary artery with pseudoaneurysm formation...
  16. ncbi The value of conservative treatment in ruptures of the anterior cruciate ligament (ACL)
    Alexander Strehl
    Department of Orthopaedic Surgery, University Hospital Inselspital, Bern, Switzerland
    J Trauma 62:1159-62. 2007
    ..Patient selection was performed using a preoperative screening protocol based on the structural damage, clinical symptoms, compliance, sportive activity, and the consent of a well-informed patient...
  17. ncbi A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen
    Chadwick C Prodromos
    Illinois Sports Medicine and Orthopaedic Centers, Glenview, Illinois 60025, USA
    Arthroscopy 23:1320-1325.e6. 2007
    ..Our purpose was to apply meta-analysis to the entire applicable literature to generate accurate estimates of the true incidences of ACL tear as a function of gender, sport, and injury-reduction training...
  18. pmc A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps
    Yuliya Vengrenyuk
    Department of Biomedical Engineering, City College of New York, Convent Avenue and 138th Street, New York, NY 10031, USA
    Proc Natl Acad Sci U S A 103:14678-83. 2006
    In this article, we advance a hypothesis for the rupture of thin fibrous cap atheroma, namely that minute (10-mum-diameter) cellular-level microcalcifications in the cap, which heretofore have gone undetected because they lie below the ..
  19. ncbi Incidence and risk factors for graft rupture and contralateral rupture after anterior cruciate ligament reconstruction
    Lucy Salmon
    Australian Institute of Musculoskeletal Research and The School of Physiotherapy, University of Sydney, Sydney, Australia
    Arthroscopy 21:948-57. 2005
    The aim of this study was to determine the rates of contralateral anterior cruciate ligament (ACL) rupture and of ACL graft rupture after ACL reconstruction using either patellar tendon or hamstring tendon autograft, and to identify any ..
  20. ncbi Diagnosis and treatment of bronchial rupture from blunt thoracic trauma
    D Chen
    Department of Thoracic Surgery, First Hospital of China Medical University, Shenyang 110001, China
    Chin Med J (Engl) 114:540-1. 2001
    ..To evaluate the diagnosis and management of bronchial rutpture from blunt thoracic trauma...
  21. ncbi Concurrent bilateral patellar tendon rupture in a preadolescent athlete: a case report and review of the literature
    Jung Ryul Kim
    Department of Orthopaedic Surgery, Chonbuk National University Medical School, Jeonju, Korea
    J Pediatr Orthop B 19:511-4. 2010
    Concurrent bilateral patellar tendon rupture in preadolescence is a very rare condition. It is mostly associated with systemic disease or steroid use in adults...
  22. ncbi Treating Achilles tendon rupture in rats with bone-marrow-cell transplantation therapy
    Naofumi Okamoto
    Department of Orthopaedic Surgery, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    J Bone Joint Surg Am 92:2776-84. 2010
    ..Therefore, we treated Achilles tendon ruptures in a rat model with transplantation of whole bone marrow cells...
  23. pmc Single-row versus double-row arthroscopic repair in the treatment of rotator cuff tears: a prospective randomized clinical study
    Ignacio Carbonel
    HU Miguel Servet, Zaragoza, Spain
    Int Orthop 36:1877-83. 2012
    ....
  24. ncbi Are obstetric anal sphincter ruptures preventable?-- large and consistent rupture rate variations between the Nordic countries and between delivery units in Norway
    Katariina Laine
    Department of Obstetrics, Oslo University Hospital, Ulleval, Oslo, Norway
    Acta Obstet Gynecol Scand 92:94-100. 2013
    To study changes in the incidence of obstetric anal sphincter rupture (OASR) during recent years in Denmark, Finland, Sweden and Norway and hospital-based incidence in recent years in Norway.
  25. ncbi Rupture of flexor tendon following volar plate of distal radius fracture. Report of five cases
    S E Valbuena
    Department of Orthopaedic Surgery and Traumatology, Hospital Interzonal El Cruce, Alta complejidad en red, Buenos Aires, Argentina
    Chir Main 29:109-13. 2010
    We report three cases of complete rupture of the flexor pollicis longus (FPL) tendon, one case of complete rupture of the index and middle finger flexor digitorum profundus tendons and one case of rupture of the flexor digitorum ..
  26. ncbi Diagnostic accuracy of magnetic resonance imaging for meniscal tears in dogs affected with naturally occuring cranial cruciate ligament rupture
    Laurent Blond
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Vet Radiol Ultrasound 49:425-31. 2008
    ..meniscal tears in dogs was evaluated in 11 dogs suffering from naturally occurring cranial cruciate ligament rupture. Dogs underwent MR imaging of the affected stifle before surgery...
  27. pmc Contralateral cruciate survival in dogs with unilateral non-contact cranial cruciate ligament rupture
    Peter Muir
    Comparative Orthopaedic Research Laboratory, and the Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e25331. 2011
    Non-contact cranial cruciate ligament rupture (CrCLR) is an important cause of lameness in client-owned dogs and typically occurs without obvious injury...
  28. ncbi Traumatic, pericardio-diaphragmatic rupture: an extremely rare cause of pericarditis
    Jeffrey Barrett
    Department of Emergency Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Emerg Med 30:141-5. 2006
    ..After surgical repair of the diaphragmatic defect and intrapericardial hernia, the EKG findings resolved. He recovered over the course of several weeks and was subsequently discharged home...
  29. pmc Liver hydatid cyst rupture into the peritoneal cavity after abdominal trauma: case report and literature review
    Mehmet Yilmaz
    Department of Surgery, Inonu University Faculty of Medicine, Division of Liver Transplantation, Malatya, Turkey
    Int Surg 97:239-44. 2012
    The aim of this study was to review the literature regarding the rupture of hydatid cysts into the abdominal cavity after trauma...
  30. pmc Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage
    Hui B Sun
    Leni and Peter May Department of Orthopaedics, Mount Sinai School of Medicine, 5 East 98th Street, 9th Floor, New York, NY 10029, USA
    Clin Orthop Relat Res 466:1555-61. 2008
    ..The data also suggest MMP-13 is regulated by both IL-1beta-dependent and IL-1beta-independent pathways...
  31. ncbi Delayed rupture of flexor pollicis longus tendon after volar plating of the distal radius
    Siu Cheong Koo
    Department of Orthopaedic and Traumatology, Caritus Medical Centre, Kowloon, Hong Kong S A R, China
    Hand Surg 11:67-70. 2006
    Flexor tendon rupture following distal radius fracture is rare. We described a case of flexor pollicis longus rupture, presented five years after volar plating of distal radius fracture.
  32. ncbi Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT study
    Lucas Elijovich
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0114, USA
    Stroke 39:1501-6. 2008
    Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established.
  33. ncbi Clinical assessments of increased sensory sensitivity in dogs with cranial cruciate ligament rupture
    N M Brydges
    Veterinary Biomedical Sciences, Royal Dick School of Veterinary Studies, The University of Edinburgh, Edinburgh EH9 1QH, UK
    Vet J 193:545-50. 2012
    ..were evaluated in dogs presenting with a naturally occurring chronic painful condition (cranial cruciate ligament rupture, CCLR) and were compared with healthy control animals of similar age and weight...
  34. ncbi Single-row versus double-row arthroscopic rotator cuff repair in small- to medium-sized tears
    Nuri Aydin
    Department of Orthopedics and Traumatology, Uskudar State Hospital, Istanbul, Turkey
    J Shoulder Elbow Surg 19:722-5. 2010
    ..Double-row rotator cuff repair leads to superior cuff integrity and clinical results compared with single-row repair...
  35. pmc Ipsilateral graft and contralateral ACL rupture at five years or more following ACL reconstruction: a systematic review
    Rick W Wright
    Department of Orthopaedics and Rehabilitation, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Bone Joint Surg Am 93:1159-65. 2011
    ..Little evidence exists regarding the intermediate to long-term risk of these events...
  36. ncbi Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy
    A N Corps
    Rheumatology Research Unit, Department of Trauman and Orthopedics, Addenbrooke s Hospital, Cambridge, UK
    Rheumatology (Oxford) 45:291-4. 2006
    ..To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons...
  37. ncbi Long-term results after primary repair or non-surgical treatment of anterior cruciate ligament rupture: a randomized study with a 15-year follow-up
    A Meunier
    Division of Orthopaedics and Sports Medicine, Department of Neurosience and Locomotion, Faculty of Health Sciences, University of Linkoping, Linkoping, Sweden
    Scand J Med Sci Sports 17:230-7. 2007
    ..to primary repair (augmented or non-augmented) or non-surgical treatment of an anterior cruciate ligament (ACL) rupture. The subjective outcome was similar between the groups, with no difference regarding activity level and knee-..
  38. ncbi CT cystography with multiplanar reformation for suspected bladder rupture: experience in 234 cases
    David P N Chan
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Shatin, Hong Kong
    AJR Am J Roentgenol 187:1296-302. 2006
    CT cystography has replaced conventional cystography in the evaluation of patients with suspected bladder rupture in most trauma centers...
  39. ncbi Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 27:274-80. 2009
    Healing after mobilization versus immobilization was assessed in a model of rat Achilles tendon rupture, by RT-PCR at 8 and 17 days and by histological analyses at 14 and 28 days postrupture...
  40. ncbi The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants
    Michael Posthumus
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Am J Sports Med 37:2234-40. 2009
    ..The COL5A1 gene, which encodes for the alpha1 chain of type V collagen, has been shown to be associated with Achilles tendon injuries...
  41. ncbi Strain energy density as a rupture criterion for the kidney: impact tests on porcine organs, finite element simulation, and a baseline comparison between human and porcine tissues
    J G Snedeker
    ETH and University Zurich, Zurich, Switzerland
    J Biomech 38:993-1001. 2005
    ..Impact energy was incrementally increased until visible rupture occurred...
  42. ncbi Management of chronic ruptures of the Achilles tendon
    Nicola Maffulli
    Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB Staffs, England
    J Bone Joint Surg Am 90:1348-60. 2008
    ..5 cm. Compared with acute injuries, chronic injuries are associated with a higher rate of postoperative infection and more prolonged recovery...
  43. ncbi Globe rupture following penetrating keratoplasty: how often, why, and what can we do to prevent it?
    Mark J Elder
    Ophthalmology Department, Christchurch Hospital, Christchurch, New Zealand
    Cornea 23:776-80. 2004
    Traumatic globe rupture following penetrating keratoplasty is a life-long postoperative concern...
  44. ncbi Suture-button versus screw fixation in a syndesmosis rupture model: a biomechanical comparison
    Sandeep P Soin
    Baltimore, MD, USA
    Foot Ankle Int 30:346-52. 2009
    Flexible suture-button devices are used to stabilize the distal tibiofibular joint after syndesmotic rupture, but little is known about how they affect fibular motion during cyclic physiological loading...
  45. ncbi The role of shear stress in the generation of rupture-prone vulnerable plaques
    C J Slager
    Hemodynamics Laboratory, Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Nat Clin Pract Cardiovasc Med 2:401-7. 2005
    ..This change causes shear stress to increase, which as a new condition may transform the lesion into a rupture-prone vulnerable plaque...
  46. ncbi The role of pro-inflammatory and immunoregulatory cytokines in tendon healing and rupture: new insights
    G Schulze-Tanzil
    Department of Trauma and Reconstructive Surgery, Charite Universitatsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Scand J Med Sci Sports 21:337-51. 2011
    ....
  47. ncbi New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats
    Kenichi Oe
    Department of Orthopaedic Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells Dev 20:671-9. 2011
    ..intra-articular bone marrow transplantation using fresh whole BMCs is an effective treatment for ACL partial rupture. This therapy is easy to apply in a clinical setting because no culture system is required for collecting MSCs.
  48. ncbi Anterior cruciate ligament injury in elite football: a prospective three-cohort study
    Markus Waldén
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:11-9. 2011
    ..These findings suggest that future preventive research primarily should address the young female football player...
  49. ncbi Acute achilles tendon rupture: a randomized, controlled study comparing surgical and nonsurgical treatments using validated outcome measures
    Katarina Nilsson-Helander
    Katarina Nilsson Helander, Department of Orthopaedics, Kungsbacka Hospital, SE 434 40 Kungsbacka, Sweden
    Am J Sports Med 38:2186-93. 2010
    There is no consensus regarding the optimal treatment for patients with acute Achilles tendon rupture. Few randomized controlled studies have compared outcomes after surgical or nonsurgical treatment with both groups receiving early ..
  50. ncbi A long-term study of anterior cruciate ligament allograft reconstruction
    K F Almqvist
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium
    Knee Surg Sports Traumatol Arthrosc 17:818-22. 2009
    ..In conclusion, the tibialis anterior or tibialis posterior tendon allograft ACL reconstruction produced good clinical results in the majority of patients at long-term follow-up...
  51. pmc Update on managing diaphragmatic rupture in blunt trauma: a review of 208 consecutive cases
    Talat Chughtai
    John and Liz Tory Regional Trauma Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont
    Can J Surg 52:177-81. 2009
    Blunt diaphragmatic rupture (BDR) is a rare event and represents a diagnostic challenge...
  52. ncbi Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques
    Markus J Leskinen
    Wihuri Research Institute, Kalliolinnantie 4, FIN 00140 Helsinki, Finland
    Biochem Pharmacol 66:1493-8. 2003
    ..A thick cap protects the lipid-rich core, whereas a thin cap predisposes it to rupture, with ensuing acute clinical complications, such as myocardial infarction...
  53. ncbi [Surgical treatment of Achilles tendon rupture]
    M H Amlang
    Klinik fur Unfall und Wiederherstellungschirurgie, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01309, Dresden, Deutschland
    Unfallchirurg 113:712-20. 2010
    The open tendon suture is the most commonly used method of treatment for Achilles tendon rupture in Germany...
  54. ncbi Acute Achilles tendon rupture: minimally invasive surgery versus nonoperative treatment with immediate full weightbearing--a randomized controlled trial
    Roderick Metz
    Diakonessenhuis, Bosboomstraat 1, 3582 KE Utrecht, Netherlands
    Am J Sports Med 36:1688-94. 2008
    ..Surgical repair of acute Achilles tendon ruptures is considered superior to nonoperative treatment, but complications other than rerupture range up to 34%. Nonoperative treatment by functional bracing seems a promising alternative...
  55. ncbi Pectoralis major muscle injuries: evaluation and management
    Julio Petilon
    Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA
    J Am Acad Orthop Surg 13:59-68. 2005
    ..Surgery, whether early or delayed, consistently yields superior results compared with nonsurgical management. Prompt diagnosis and timely intervention likely will produce improved results...
  56. pmc Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture
    Jacques Ohayon
    National Heart, Lung and Blood Institute, NIH, Bldg 10, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 295:H717-27. 2008
    ..it remains unclear how these interact and affect peak cap stress (Cap(stress)), a known predictor of rupture. The aim of this study was to investigate the change in plaque vulnerability as a function of necrotic core size ..
  57. ncbi Rupture of the pectoralis major muscle
    Ville Aärimaa
    Department of Surgery, Turku University Hospital, Finland
    Am J Sports Med 32:1256-62. 2004
    Total or near-total rupture of the pectoralis major muscle is a rare injury. Fewer than 200 cases have been reported in literature, many of them in single case reports...
  58. ncbi Diagnosis and management of bladder injury by trauma surgeons
    Chi Hsun Hsieh
    Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Am J Surg 184:143-7. 2002
    ..However, bladder injuries are usually associated with other major injuries, and it is our concern here how bladder injuries have been managed as part of multiple trauma...
  59. ncbi Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 74:337-45. 2010
    ..and its cognate receptor, CX3CR1, play a role in atherogenesis, so the relationship between coronary plaque rupture, as observed by preintervention optical coherence tomography, and plasma levels of FKN and CX3CR1 was ..
  60. ncbi The Achilles tendon Total Rupture Score (ATRS): development and validation
    Katarina Nilsson-Helander
    Lundberg Laboratory for Orthopaedic Research, Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Am J Sports Med 35:421-6. 2007
    There is a need for a patient-relevant instrument to evaluate outcome after treatment in patients with a total Achilles tendon rupture.
  61. ncbi Major functional deficits persist 2 years after acute Achilles tendon rupture
    Nicklas Olsson
    Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:1385-93. 2011
    ..this prospective randomized controlled study was to evaluate the long-term results after an acute Achilles tendon rupture in patients treated surgically or non-surgically...
  62. ncbi Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 25:2054-61. 2005
    ..This review discusses the potential role of intraplaque vasa vasorum in lesion instability as it relates to plaque rupture.
  63. pmc Carotid atheroma rupture observed in vivo and FSI-predicted stress distribution based on pre-rupture imaging
    Joseph R Leach
    UC Berkeley UC San Francisco Joint Graduate Group in Bioengineering, Berkeley, CA, USA
    Ann Biomed Eng 38:2748-65. 2010
    ..It is hoped that patient-specific biomechanical analyses may serve clinically to assess the rupture potential for any particular lesion, allowing better stratification of patients into the most appropriate ..
  64. pmc TNF-alpha-mediated inflammation in cerebral aneurysms: a potential link to growth and rupture
    Thottala Jayaraman
    Department of Neurosurgery, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Vasc Health Risk Manag 4:805-17. 2008
    Intracranial aneurysm (IA) rupture is one of the leading causes of stroke in the United States and remains a major health concern today. Most aneurysms are asymptomatic with a minor percentage of rupture annually...
  65. ncbi Caudal cruciate ligament damage in dogs with cranial cruciate ligament rupture
    Julia P Sumner
    Department of Surgical Sciences, University of Wisconsin Madison, School of Veterinary Medicine, Madison, WI, USA
    Vet Surg 39:936-41. 2010
    To investigate the incidence of caudal cruciate ligament (CaCL) damage in dogs with cranial cruciate ligament rupture (CCLR).
  66. ncbi Increased content of type III collagen at the rupture site of human Achilles tendon
    Heidi A Eriksen
    Department of Clinical Chemistry, University of Oulu, P O Box 5000, FIN 90014, Oulu, Finland
    J Orthop Res 20:1352-7. 2002
    We compared the type I and III collagen amounts and cross-linked telopeptides at the rupture site and two other sites of the same tendon...
  67. ncbi Effects of postoperative rehabilitation on limb function after cranial cruciate ligament repair in dogs
    Gregory S Marsolais
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50010, USA
    J Am Vet Med Assoc 220:1325-30. 2002
    ..To determine the effects of early postoperative rehabilitation on limb function in dogs after surgery for ruptured cranial cruciate ligament (RCCL)...
  68. ncbi Consensus statement on bladder injuries
    Reynaldo G Gomez
    Department of Urology, Santiago, Chile
    BJU Int 94:27-32. 2004
  69. ncbi Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases
    T J W Matthews
    Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 88:489-95. 2006
    ..Tissue from large and massive tears is of such a degenerative nature that it may be a significant cause of re-rupture after surgical repair and could make healing improbable in this group.
  70. ncbi Platelet concentrate injection improves Achilles tendon repair in rats
    Per Aspenberg
    Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Science, SE 581 85 Linkoping, Sweden
    Acta Orthop Scand 75:93-9. 2004
    ..Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair...
  71. ncbi Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors
    Hugues Louboutin
    Service de Chirurgie Orthopedique et Traumatologique, CHU Cavale Blanche Brest Cedex, France
    Knee 16:239-44. 2009
    ..factors for the development of osteoarthritis (OA) in patients who have had an anterior cruciate ligament (ACL) rupture are reviewed...
  72. ncbi Blunt tracheobronchial injuries: treatment and outcomes
    A C Kiser
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill 27599-7065, USA
    Ann Thorac Surg 71:2059-65. 2001
    ..We are also able to assess the mortality associated with the location and side of injury, examine the time from injury until diagnosis and treatment, and evaluate treatment outcome...
  73. ncbi CT cystography in the evaluation of major bladder trauma
    J P Vaccaro
    Department of Diagnostic Imaging, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Radiographics 20:1373-81. 2000
    ..In bladder contusion (type 1), findings are normal. In intraperitoneal rupture (type 2), CT cystography demonstrates intraperitoneal contrast material around bowel loops, between mesenteric ..
  74. pmc Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice
    D L Miller
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 97:10179-84. 2000
    ..hemorrhages (PHs) in intestine and abdominal muscle were counted 15 min after exposure to characterize capillary rupture, and Evans blue extravasation was evaluated in samples of muscle tissue...
  75. ncbi Pathologic changes in grossly normal menisci in dogs with rupture of the cranial cruciate ligament
    J Jackson
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    J Am Vet Med Assoc 218:1281-4. 2001
    ..To determine whether histopathologic changes are detectable in grossly normal medial menisci from dogs with rupture of the cranial cruciate ligament (CCL). DESIGN: Case series...
  76. ncbi Estimate of the annual economic impact of treatment of cranial cruciate ligament injury in dogs in the United States
    Vicki L Wilke
    Department of Animal Sciences and Center for Integrated Animal Genomics, College of Veterinary Medicine, Iowa State University, Ames 50011 1250, USA
    J Am Vet Med Assoc 227:1604-7. 2005
    To estimate the economic impact to veterinary clients for the medical and surgical treatment of rupture of the cranial cruciate ligament (RCCL) in dogs for the year 2003.
  77. ncbi Age, tibial plateau angle, sex, and weight as risk factors for contralateral rupture of the cranial cruciate ligament in Labradors
    Nicole Buote
    Animal Medical Center, New York, NY 10021, USA
    Vet Surg 38:481-9. 2009
    To compare rates of contralateral cranial cruciate ligament rupture (CCLR) in Labradors based on age and weight at initial rupture, sex, and tibial plateau angle (TPA) and to determine whether Labradors that rupture their initial cranial ..
  78. ncbi Prevalence of lymphoplasmacytic synovitis in dogs with naturally occurring cranial cruciate ligament rupture
    Jay B Erne
    Affiliated Veterinary Specialists, 275 Corporate Way, Ste 100, Orange Park, FL 32073, USA
    J Am Vet Med Assoc 235:386-90. 2009
    To determine the prevalence of lymphoplasmacytic synovitis (LPS) in dogs with naturally occurring cranial cruciate ligament (CCL) rupture and compare clinical, radiographic, cytologic, and histologic findings in dogs with and without LPS.
  79. ncbi Immunopathological mechanisms in dogs with rupture of the cranial cruciate ligament
    M Doom
    Department of Small Animal Medicine and Clinical Biology, Ghent University, 9820 Merelbeke, Belgium
    Vet Immunol Immunopathol 125:143-61. 2008
    ..on cranial cruciate ligament (CrCL) disease to date have been carried out on dogs that already sustained a CrCL rupture, which is the end-stage of the disease...
  80. ncbi Comparison of tibial plateau angles in dogs with unilateral versus bilateral cranial cruciate ligament rupture: 150 cases (2000-2006)
    Sady Y Cabrera
    Department of Surgery, VCA West Los Angeles Animal Hospital, 1818 S Sepulveda Blvd, Los Angeles, CA 90025, USA
    J Am Vet Med Assoc 232:889-92. 2008
    To compare tibial plateau angle (TPA) in dogs with unilateral versus bilateral cranial cruciate ligament (CCL) rupture, to compare right versus left TPA in dogs with bilateral CCL rupture, and to determine whether TPA can be used to ..
  81. ncbi Lymphocyte populations in joint tissues from dogs with inflammatory stifle arthritis and associated degenerative cranial cruciate ligament rupture
    Peter Muir
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Vet Surg 40:753-61. 2011
    To evaluate lymphocyte populations in stifle synovium and synovial fluid of dogs with degenerative cranial cruciate ligament rupture (CCLR).
  82. ncbi The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis
    L Stefan Lohmander
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Am J Sports Med 35:1756-69. 2007
    ....
  83. ncbi High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture-prone lesions
    Mihaela G Ionita
    Experimental Cardiology Laboratory, Cardiology, Heart and Lung, University MedicalCenter Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1842-8. 2010
    ..To score the number of plaque neutrophils and relate the score to plaque morphology and inflammatory status...
  84. ncbi Radiographic assessment of the progression of osteoarthrosis in the contralateral stifle joint of dogs with a ruptured cranial cruciate ligament
    T de Bruin
    Department of Diagnostic Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Rec 161:745-50. 2007
    ..in the unaffected contralateral stifle joints of 14 dogs with a unilateral cranial cruciate ligament rupture were monitored radiographically in terms of a global score and the scores for 10 parameters specific for the ..
  85. pmc Collagens, proteoglycans, MMP-2, MMP-9 and TIMPs in human achilles tendon rupture
    Evgenia Karousou
    Department of Experimental Biomedical and Clinical Sciences DSBSC, University of Insubria, Varese, Italy
    Clin Orthop Relat Res 466:1577-82. 2008
    ..However, it is unclear which enzymes play a role in tendon rupture. We studied the ECM of 19 ruptured human Achilles tendons, comparing the composition of specimens harvested close ..
  86. ncbi The risk of anterior cruciate ligament rupture with generalised joint laxity
    R Ramesh
    Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital NHS Trust Wonford, Barrack Road, Exeter EX2 5DW, UK
    J Bone Joint Surg Br 87:800-3. 2005
    ..Statistical analysis showed a significant correlation for these associations. We conclude that anterior cruciate ligament injury is more common in those with joint laxity and particularly so for those with hyperextension of the knee...
  87. ncbi Is percutaneous repair of the Achilles tendon a safe technique? A study of 124 cases
    Renaud Maes
    Clinique Louis Caty, Baudour, Belgium
    Acta Orthop Belg 72:179-83. 2006
    Ma and Griffith first described in 1977 a percutaneous technique for the repair of acute Achilles tendon rupture. In 1992, Delponte popularised a new percutaneous technique with Tenolig...
  88. ncbi Intraarticular rupture pattern of the ACL
    Thore Zantop
    Department of Trauma, Hand and Reconstructive Surgery, Wilhelms University Muenster, Germany
    Clin Orthop Relat Res 454:48-53. 2007
    To date, the intraarticular rupture pattern of the anterior cruciate ligament (ACL) has not been reported...
  89. ncbi Tracheal rupture after endotracheal intubation: a literature systematic review
    Eduardo Minambres
    Service of Intensive Care, Marques de Valdecilla University Hospital, Santander 39008, Spain
    Eur J Cardiothorac Surg 35:1056-62. 2009
    We aim to perform a systematic review and meta-analysis of the cases of postintubation tracheal rupture (PiTR) published in the literature, with the aim of determining the risk factors that contribute to tracheal rupture during ..
  90. ncbi Late presentation of blunt right diaphragmatic rupture (hepatic hernia)
    Orhan Kozak
    Department of General Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    Am J Emerg Med 26:638.e3-5. 2008
    Diaphragmatic rupture occurs in 0.8% to 3.6% of patients after blunt or penetrating thoracoabdominal trauma, and the preoperative diagnosis is difficult...
  91. ncbi Long-term outcome of operative or nonoperative treatment of anterior cruciate ligament rupture--is sports activity a determining variable?
    C Fink
    University Hospital for Traumatology, Innsbruck, Austria
    Int J Sports Med 22:304-9. 2001
    ..Sports activity represents an important variable not only affecting the outcome, but also influencing treatment decisions following ACL injuries...
  92. ncbi Animal model that mimics atherosclerotic plaque rupture
    M D Rekhter
    Department of Vascular and Cardiac Diseases, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, MI 48105, USA
    Circ Res 83:705-13. 1998
    Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption...
  93. ncbi Long-term follow-up after primary repair of the anterior cruciate ligament: clinical and radiological evaluation 15-23 years postoperatively
    T Strand
    Department of Orthopaedic Surgery, Diakonissehjemmets sykehus, 5009 Bergen, Norway
    Arch Orthop Trauma Surg 125:217-21. 2005
    ..We have previously reported results after 2-5 and 5-10 years follow-up of repair of acute anterior cruciate ligament (ACL) ruptures by suturing. Reports of results after more than 10 years are rare...
  94. ncbi Achilles tendon rupture and our experience with the Achillon device
    Zeev Feldbrin
    Department of Orthopedics, Wolfson Medical Center, Holon, Israel
    Isr Med Assoc J 12:609-12. 2010
    Open repair of the Achilles tendon is still the gold standard for treating rupture. This technique has the disadvantages of a long and problematic operative scar and thickly scarred Achilles tendon...
  95. ncbi Rupture of the subscapularis tendon (isolated or in combination with supraspinatus tear): when is a repair indicated?
    Matthias P Flury
    Orthopedics Department, Upper Extremity Unit, Schulthess Clinic, Zurich, Switzerland
    J Shoulder Elbow Surg 15:659-64. 2006
    ..Of 1345 patients who underwent rotator cuff repair in a 7-year period, 73 had either an isolated rupture of the subscapularis or a subscapularis rupture combined with rupture of the supraspinatus...
  96. ncbi Intra myocardial dissecting hematoma with epicardial rupture - an unusual complication of the Octopus 3 stabilizer
    N V Mandke
    Lilavati Hospital and Research Center, A 791, Bandra Reclamation, Bandra W, Mumbai, India
    Eur J Cardiothorac Surg 21:566-7. 2002
    ..We report here an unusual complication of an intramyocardial dissecting hematoma with epicardial rupture caused after using the Octopus 3 stabilizer.
  97. ncbi Latent fatality due to hydatid cyst rupture after a severe cough episode
    Besir Erdogmus
    Department of Radiology, Abant Izzet Baysal University, Duzce Medical School, Duzce, Turkey
    Tohoku J Exp Med 205:293-6. 2005
    ..The infestation mostly involves the liver. Hydatid cysts of the liver can rupture either spontaneously or due to trauma. Incidence of rupture is about 3-17% of all cases with hydatid disease...
  98. ncbi Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture
    Noriaki Kume
    Circ Res 94:269-70. 2004
  99. ncbi Pectoralis major rupture in the elderly: clinical and sonographic findings
    Yichayaou Beloosesky
    Department of Geriatrics, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Imaging 27:261-4. 2003
    We describe clinical and sonographic features of pectoralis major rupture in the elderly, which is relatively rare and unknown. Patients presented with a large pectoral ecchymosis extending to the axilla, chest wall, breast and arm...
  100. ncbi Levofloxacin-associated Achilles tendon rupture
    A Scott Mathis
    Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Ann Pharmacother 37:1014-7. 2003
    To describe a case of levofloxacin-induced partial Achilles tendon rupture; this occurred in the presence of known risk factors and acute renal failure.
  101. ncbi Prosthesis oversizing in balloon-expandable transcatheter aortic valve implantation is associated with contained rupture of the aortic root
    Philipp Blanke
    Department of Diagnostic Radiology, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Circ Cardiovasc Interv 5:540-8. 2012
    To retrospectively investigate the potential cause of contained rupture of the aortic root in balloon-expandable transcatheter aortic valve implantation (TAVI) by means of pre- and postinterventional multislice computed tomography.

Research Grants76

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..formation, manifesting as sudden loss of vision, stroke, myocardial ischemia, aortic arch syndrome, and aneurysm rupture. Once diagnosed, the IVS are considered medical emergencies...
  2. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..The overfilled particles are then decompressed and, as a result of rapid phase conversion, rupture at their weakest points...
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..biochemical dimension to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis...
  4. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..This leads to swelling and rupture of the mitochondria, cytochrome c release and apoptosis. We developed a mitochondrial targeting strategy (U.S...
  5. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..neonates with severe forms of the disease characterized by full-thickness necrosis of the intestine, followed by rupture and sepsis...
  6. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..The HIV membrane rupture is specific because C5A does not disturb the integrity of the plasma membrane of human cells even when used at ..
  7. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..These plaques often rupture, causing myocardial infarction, stroke, or death...
  8. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..5 million Americans afflicted annually. Almost all MIs are caused by rupture of coronary atherosclerotic plaques with superimposed coronary thrombosis resulting in ischemia...
  9. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..and specific Change Topic, 06- HL-101 "Developing technologies for assessment of aortic aneurysms prone to rupture or dissection". Aortic dissection describes a tear in the wall of the main vessel in the body, the aorta...
  10. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..These plaques often rupture, causing myocardial infarction, stroke, or death...
  11. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..and abuse and, in some cases, mode of delivery;2) intra-partum factors such as presence and duration of labor and rupture of membranes, chorioamnionitis, antenatal corticosteroids, and mode of delivery;and 3) postnatal factors such as ..
  12. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..Content expertise includes prematurity, premature rupture of membranes, fetal growth restriction, racial disparities, maternal immunization, and maternal medical ..
  13. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013
    ..the mechanisms by which these lipids or their products induce vascular injury, and promote plaque formation or rupture are unknown...
  14. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..inflammatory disease of the aorta that can result in dissection of the wall, formation of an intramural clot, and rupture of th aorta resulting in almost immediate death in the majority of cases...
  15. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels within the subependymal brain tissue. Occurring in approximately 3...
  16. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..involving multiple cell types and proteins in various stages of initiation, progression, and eventually plaque rupture which is responsible for mortality and morbidity...
  17. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..The rationale for the proposed research is that because cerebral aneurysms can be diagnosed before they rupture, a therapy that would repair the aneurysm inflammatory process and prevent aneurysms from progressing to rupture, ..
  18. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Diseased blood vessel walls frequently develop lesions that can become unstable and rupture. The rupture leads to blocking blood supply and death of tissues in the brain and heart and may result in ..
  19. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..target oxidization-specific epitopes, present on oxLDL, may enable early in vivo detection of plaque prone to rupture. We have reported that oxLDL targeted gadolinium (Gd) micelles may be used for in vivo MR detection of oxidation-..
  20. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..Impaired angiogenesis in the infarcted heart can lead to rupture and immature/weakened scar tissue...
  21. Calcification and Vascular Cell Differentiation
    Cecilia M Giachelli; Fiscal Year: 2013
    ..It leads to cardiac valve stenosis, increased pulse pressure, hypertension and may contribute to plaque rupture, all of which can lead to heart failure...
  22. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..Such mRNAs are likely involved in activities necessary for follicle rupture, which include the formation of a hyaluronan-rich extracellular matrix between cumulus cells and the loss of ..
  23. Multifunctional nanoformulations for diagnostic imaging of atherosclerosis
    Alexander B Sigalov; Fiscal Year: 2012
    ..A vast majority of cardiovascular events such as stroke or myocardial infarction result from rupture or erosion of vulnerable atherosclerotic plaques...
  24. Cthrc1 function as a novel TGF-beta antagonist in the vasculature
    Volkhard Lindner; Fiscal Year: 2013
    ..In many tissues of affected mice, bleeding is observed that appears to be caused by rupture of malformed vessels. Thus Cthrc1 is an essential molecule with partial penetrance of lethal haploinsufficiency...
  25. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    Preterm premature rupture of the fetal membranes (PPROM) is a major cause of maternal morbidity and premature birth...
  26. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    ..In recent work, we used a novel laser-based approach to rupture targeted arterioles in the brain of mice and imaged the impact of these lesions using two-photon microscopy...
  27. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..to the anterior cruciate ligament (ACL) and meniscus, show that even with surgical reconstruction after traumatic rupture there is a significant increase in the risk of a long term, chronic disease called osteoarthritis (OA)...
  28. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..Vaginalis), treatments for those at imminent risk (antibiotics for preterm labor and premature rupture of the membranes, repeated antenatal corticosteroids, magnesium sulfate neuroprotection), cesarean delivery and ..
  29. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..A SAH occurs when large vessels in the brain rupture and bleed into the fluid filled space surrounding the brain...
  30. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..humans, DAA affects those in the teen years to early adulthood, resulting in occlusion of distal vessels, aortic rupture, and sudden death...
  31. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..in both the thoracic and abdominal regions of the aortic tree and can deteriorate to vascular dissection and/or rupture that constitute a significant source of morbidity and mortality...
  32. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..The overfilled particles are then decompressed and, as a result of rapid phase conversion, rupture at their weakest points...
  33. Microfibril Fragments: Biomarkers of Aortic Disease
    Lynn Y Sakai; Fiscal Year: 2010
    Develop technologies for assessment of aortic aneurysms prone to rupture or dissection...
  34. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..3) Elucidate the role of syndecan-1 in modulating aneurysm formation and rupture via a regulatory effect on inflammatory and proteolytic responses...
  35. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..mentors, including polycystic ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea vaccine development, steroidogenesis, and promotion of healthy pregnancy...
  36. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..are central to early development of atherosclerosis and also to late-stage events, such as plaque instability and rupture. What remains unclear is the pathway by which air pollution toxicity is transferred from the lung to the ..
  37. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
    ..Therefore TF may play a role in plaque progression and may mediate thrombosis in association with plaque rupture. We have recently developed a mouse, TF/Sm221Cre, that has a >95% deficiency in SMC-derived TF...
  38. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    ..Thoracic aortic aneurysm (TAA) disease is a potentially devastating disease process which often causes death by rupture in the absence of symptoms...
  39. Nuclear mechanics and mechanotransduction in muscular laminopathies
    Jan Lammerding; Fiscal Year: 2013
    ..through two, possibly overlapping mechanisms: (i) loss of structural function of lamins A and C, leading to rupture of the more fragile nucleus in mechanically stressed tissues;(ii) disturbing (mechanosensitive) signaling ..
  40. Myeloid cell interactions with T cells in atherosclerosis
    Klaus F Ley; Fiscal Year: 2013
    ..Macrophages are also critically involved in vulnerable plaque, whose rupture triggers major adverse cardiovascular events (MACE)...
  41. GPCR Kinase-2 in TNFalpha Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
    ..role in all stages of atherogenesis including fatty streaks to advanced plaques and eventually to plaque rupture. Thus, understanding the biochemical mechanisms by which macrophage biology (including inflammatory mediator ..
  42. Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) Trial
    Alan Thevenet N Tita; Fiscal Year: 2013
    ..infection despite standard prophylaxis - those undergoing a non-elective cesarean during labor or after membrane rupture. These women face a high likelihood of ascending colonization and infection with ureaplasmas from the lower ..
  43. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Subarachnoid hemorrhage resulting from aneurysmal rupture causes severe morbidity and high mortality. The management of unruptured intracranial aneurysms remains controversial...
  44. Bioluminescence Imaging of Atherosclerosis Associated Reactive Oxygen Species
    REECE JOSEPH GOIFFON; Fiscal Year: 2013
    ..in the arterial walls of CVD patients, mainly in and around inflamed plaques, and directly contribute to their rupture. The goal of this proposal is to develop BLI to detect ROS produced by these cells in animal models, thus ..
  45. A new smart neonatal incubator for real-time detection of sepsis
    De Ann M Pillers; Fiscal Year: 2013
    ..Chorioamnionitis is a leading cause of prelabor preterm rupture of membranes (PPROM) and a leading cause of premature birth (<35 weeks)...
  46. Insulin-Like Growth Factor-1 and Atherosclerosis
    Patrice Delafontaine; Fiscal Year: 2013
    ..be very important clinically, since most acute cardiovascular events result from plaque instability, erosion and rupture, rather than changes in plaque burden...
  47. NIR Light-Activated Nanoparticles for Drug and Gene Delivery
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
    ..friendly NIR light energy absorbed by the HGN to heat, creating unstable microbubbles that mechanically rupture endosomes and release siRNA to the cytosol within seconds...
  48. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    ..of the devastating complications of intraluminal thrombus is the acute occlusion of a coronary artery following rupture of a vulnerable plaque, which can cause sudden death...
  49. Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    Dominik R Haudenschild; Fiscal Year: 2013
    ..A single non-invasive mechanical load applied to the knee induces ACL rupture. Comparable to human ACL injuries, we observe an acute inflammatory response and joint swelling that resolves in ..
  50. Effects of mechanical forces on lung injury and repair
    Bela Suki; Fiscal Year: 2010
    ..Our previous studies have shown that such mechanical forces in the emphysematous lung are able to rupture the collagen...
  51. Targeting the Foam Cell to Prevent Atherosclerosis
    ANTONIO PAUL; Fiscal Year: 2013
    ..or "foam cells" play crucial roles in all the stages of atherogenesis, from lesion initiation to plaque rupture. However, our current therapeutic arsenal lacks of drugs primarily targeting the foam cell to prevent ..
  52. HEMODYNAMICS OF CEREBRAL ARTERIOVENOUS MALFORMATIONS
    Hua Su; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Brain arteriovenous malformation (AVM) patients are at risk of rupture and intracranial hemorrhage (ICH)...
  53. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    ..g. coronary artery disease, it is a clinically insidious disease with high fatality. If untreated, rupture occurs in 70% of patients resulting in a 94% mortality rate, which makes it a high impact health problem at both ..
  54. Mechanisms of Fibronectin Extra Domain A in Atherosclerosis
    Anil Kumar Chauhan; Fiscal Year: 2013
    ..Clinically it is evident that plaque rupture, the most important cause of coronary thrombosis, is often associated with myocardial infarction and death...
  55. Age-Dependent Mechanisms in Thoracic Aortic Aneurysms
    John S Ikonomidis; Fiscal Year: 2013
    ..TAA disease is an insidious process which often causes death by rupture in the absence of antecedent symptomology...
  56. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..These DCs express specific atherogenic biomarkers that can promote plaque rupture, thrombus formation, and increase risk of heart attack and stroke...
  57. The Role of Biglycan in Reproduction
    BEATRICE ELIZABETH LECHNER; Fiscal Year: 2013
    ..Preterm premature rupture of membranes (PPROM) is a significant underlying cause of premature delivery...
  58. Novel Biomarkers to Identify Vulnerable Patients with Coronary Artery Disease
    Marc S Sabatine; Fiscal Year: 2012
    ..Whereas some patients will have quiescent disease, others will suffer plaque rupture and develop acute, overt ischemic complications...
  59. Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ..for stabilizing coronary atherosclerotic lesions and may be of particular importance in the friable, prone to rupture SVG plaques...
  60. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..The aneurysm weakens the wall of the aorta and can result in rupture. Because the volume of blood flowing through the aorta is under relatively high pressure, a rupture can be ..
  61. Gender Specific Evolution of Abdominal Aortic Aneurysm Composition and Properties
    Jay D Humphrey; Fiscal Year: 2013
    ..Although maximum diameter has long been the primary clinical metric for assessing rupture-potential, recent studies demonstrate that wall stress is a far better predictor...
  62. The role of lectin-complexes in complement-mediated coagulopathy
    Laura R La Bonte; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Project Narrative Occlusive thrombosis, resulting from atherosclerotic plaque rupture or restinosis, plays an important role in the onset of two major causes of death in developed nations: myocardial ..
  63. Use Of Adipose Derived Stem Cells For Engineering Of Ligament Tissue
    David McAllister; Fiscal Year: 2012
    Abstract: Rupture of the anterior cruciate ligament (ACL) is one of most common ligament injuries of the knee and is often seen in the VA patient population...
  64. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    Traumatic Aortic Rupture (TAR) is a leading cause of fatality in motor vehicle accidents. About 20 percent of fatalities in motor vehicle crashes are caused by aortic injuries...
  65. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..The aneurysm weakens the wall of the aorta and can result in rupture. Because the volume of blood flowing through the aorta is under relatively high pressure, a rupture can be ..
  66. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..investigate the central hypothesis that, once an aneurysm is diagnosed, the primary biomechanical determinant of rupture potential is the non-uniform arterial wall thickness, within the context of a dynamic assessment of aneurysm ..
  67. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    The goal of the proposed studies is to elucidate the mechanism of endothelin-2 (EDN-2) action in follicle rupture. The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, ..
  68. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    Ovulation has been described as a pathophysiological event in which the controlled dissolution and rupture followed by repair of otherwise healthy tissue occurs...
  69. INCIDENCE AND RISK FACTORS FOR UTERINE RUPTURE
    George Macones; Fiscal Year: 2000
    ..Although this procedure is generally believed to be safe, there is a small risk of uterine rupture in these women...
  70. Endovascular device and treatment for stabilizing aortic aneurysms
    MATTHEW FRANK OGLE; Fiscal Year: 2010
    ..AAAs) are associated with impaired arterial wall integrity, leading to abnormal ballooning and eventual fatal rupture. Currently the sole treatment for such aneurysms is surgical intervention...
  71. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ..If the diagnosis of EP is delayed potential rupture, resulting in greater risks of morbidity and mortality, can occur...
  72. Multi-analyte Biosensor for Emerging Cardiac Markers
    CHARLES PENNINGTON; Fiscal Year: 2001
    ..kinase MB, and myoglobin attempt to address this need, but only identify downstream effects of a plaque rupture event...
  73. THE ROLE OF WALL STRESS DISTRIBUTION IN ABDOMINAL AORTIC
    Mark Fillinger; Fiscal Year: 2001
    ..aortic aneurysm (AAA), physicians have long sought the ability to reliably identify patients with a high risk of rupture and those who are relatively safe from rupture...
  74. HDL AND PLAQUES--NOVEL MODELS AND IMAGING TECHNIQUES
    Edward Fisher; Fiscal Year: 2001
    Vulnerable plaques are prone to rupture and can cause acute coronary syndromes...
  75. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001
    The proposed study is designed to identify etiologic factors for preterm premature rupture of the membranes (preterm PROM) in which preterm delivery is precipitated by rupture of the chorioamnionic membranes...
  76. BIOMECHANICAL EVALUATION OF ABDOMINAL AORTIC ANEURYSM
    DAVID ALAN VORP; Fiscal Year: 2010
    ..If left untreated, AAA will gradually expand until rupture, an event that carries a mortality rate of 90%...