Genomes and Genes
Summary: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in chordates.
Publications303 found, 100 shown here
- Stereotactic body radiotherapy for organ-confined prostate cancerAlan J Katz
Winthrop University Hospital, 264 Old Country Road, Mineola, NY 11501, USA
BMC Urol 10:1. 2010..We present preliminary results following stereotactic body radiotherapy (SBRT) treatment for organ-confined prostate cancer...
- Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trialEric L Chang
Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
Lancet Oncol 10:1037-44. 2009..We proposed that the learning and memory functions of patients who undergo SRS plus WBRT are worse than those of patients who undergo SRS alone. We did a randomised controlled trial to test our prediction...
- Intensity-modulated radiation therapy, protons, and the risk of second cancersEric J Hall
Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 65:1-7. 2006..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT...
- Use of normal tissue complication probability models in the clinicLawrence B Marks
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
Int J Radiat Oncol Biol Phys 76:S10-9. 2010..A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included...
- Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancerMichael J Zelefsky
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Int J Radiat Oncol Biol Phys 70:1124-9. 2008..To report the incidence and predictors of treatment-related toxicity at 10 years after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer...
- Radiation-associated liver injuryCharlie C Pan
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 5010, USA
Int J Radiat Oncol Biol Phys 76:S94-100. 2010..This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver...
- Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experiencePatrick A Kupelian
Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
Int J Radiat Oncol Biol Phys 68:1424-30. 2007..To study the outcomes in patients treated for localized prostate cancer with 70 Gy delivered at 2.5-Gy/fraction within 5 weeks...
- Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinomaRegina V Tse
Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
J Clin Oncol 26:657-64. 2008..To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC)...
- Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complicationSeok Hyun Son
Department of Radiation Oncology, College of Medicine, Catholic University of Korea, Seoul, Korea
Int J Radiat Oncol Biol Phys 78:1073-80. 2010..To identify the parameters that predict hepatic toxicity and deterioration of hepatic function...
- Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registriesSarah C Darby
Clinical Trial Service Unit, University of Oxford, Oxford, UK
Lancet Oncol 6:557-65. 2005..This study aimed to assess the hazards in the general US population from routine cancer-registry and death-certificate data...
- Radiation dose-volume effects in radiation-induced rectal injuryJeff M Michalski
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 76:S123-9. 2010..It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions...
- Evolution of radiation-induced brain injury: MR imaging-based studyYi Xiang J Wang
Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
Radiology 254:210-8. 2010..To evaluate the temporal lobes in patients previously treated for nasopharyngeal carcinoma to provide a better understanding of delayed radiation-induced injury in the brain unaffected by the underlying tumor...
- Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis studyGillian C Barnett
University of Cambridge, Department of Oncology, Cambridge, UK
Lancet Oncol 13:65-77. 2012..Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset...
- Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trialHidefumi Aoyama
Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
JAMA 295:2483-91. 2006..In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone...
- Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working GroupJamie K Waselenko
Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
Ann Intern Med 140:1037-51. 2004..for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, ..
- Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapyVinai Gondi
Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
Int J Radiat Oncol Biol Phys 78:1244-52. 2010..Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases...
- Protection against ionizing radiation by antioxidant nutrients and phytochemicalsJoseph F Weiss
Office of Health Studies, US Department of Energy, EH 6 270 Corporate Square, 1000 Independence Avenue, SW, Washington, DC 20585 0270, USA
Toxicology 189:1-20. 2003..In addition, further studies are required to determine the potential value of specific antioxidant nutrients and phytochemicals during radiotherapy for cancer...
- Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathologySøren M Bentzen
University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, K4 316 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
Nat Rev Cancer 6:702-13. 2006..This stimulates research into new pharmacological strategies for preventing or reducing the side effects of radiation therapy...
- Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its managementJing Chen
Cancer Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Radiat Oncol 6:128. 2011....
- Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation toleranceShi xiong Liang
Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China
Int J Radiat Oncol Biol Phys 65:426-34. 2006..To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation...
- Clinical features, mechanisms, and management of pseudoprogression in malignant gliomasDieta Brandsma
Department of Neuro Oncology, Daniel den Hoed Cancer Centre, Erasmus Medical Centre, Rotterdam, Netherlands
Lancet Oncol 9:453-61. 2008..Further research is needed to establish reliable imaging parameters that distinguish between true tumour progression and pseudoprogression or treatment-related necrosis...
- Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issuesSøren M Bentzen
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Int J Radiat Oncol Biol Phys 76:S3-9. 2010..Research priorities for the next 5-10 years are proposed...
- Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous systemVictor A Levin
Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Int J Radiat Oncol Biol Phys 79:1487-95. 2011..To conduct a controlled trial of bevacizumab for the treatment of symptomatic radiation necrosis of the brain...
- Major radiation exposure--what to expect and how to respondFred A Mettler
Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
N Engl J Med 346:1554-61. 2002
- p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosisDavid G Kirsch
David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 327:593-6. 2010..These results suggest that the GI syndrome is caused by the death of GI epithelial cells and that these epithelial cells die by a mechanism that is regulated by p53 but independent of apoptosis...
- Effect of bevacizumab on radiation necrosis of the brainJavier Gonzalez
Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Int J Radiat Oncol Biol Phys 67:323-6. 2007..Because blocking vascular endothelial growth factor (VEGF) from reaching leaky capillaries is a logical strategy for the treatment of radiation necrosis, we reasoned that bevacizumab might be an effective treatment of radiation necrosis...
- Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapyMitchell S Anscher
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
Oncologist 15:350-9. 2010....
- Reirradiation tolerance of the human brainRamona Mayer
Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria
Int J Radiat Oncol Biol Phys 70:1350-60. 2008..To give an overview of current available clinical data on reirradiation of glioma with respect to the tolerance dose of normal brain tissue...
- TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?M Martin
Laboratoire de Radiobiologie et d Etude du Génome, DRR, DSV, C E A, Saclay, France
Int J Radiat Oncol Biol Phys 47:277-90. 2000....
- Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001C Norman Coleman
Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 159:812-34. 2003..The resulting radiation injuries would be due to a series of molecular, cellular, tissue and whole-animal processes...
- Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient dataJean Bourhis
Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France
J Clin Oncol 29:2590-7. 2011..The aim of this meta-analysis was to evaluate the impact of amifostine on overall survival (OS) and progression-free survival (PFS) in patients treated with radiotherapy or chemoradiotherapy...
- Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampusLei Shi
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Radiat Res 166:892-9. 2006..These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition...
- Intensity-modulated radiotherapy reduces gastrointestinal toxicity in patients treated with androgen deprivation therapy for prostate cancerNavesh K Sharma
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 80:437-44. 2011..The present study compared the genitourinary and gastrointestinal (GI) toxicity in men treated with 3D-CRT+AD vs. IMRT+AD...
- Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosisRoy Torcuator
Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
J Neurooncol 94:63-8. 2009..We retrospectively reviewed 6 patients with biopsy proven cerebral radiation necrosis treated with bevacizumab between 2006 and 2008...
- Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapyTae Hyun Kim
Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
Int J Radiat Oncol Biol Phys 67:225-31. 2007..To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy...
- Chronic oxidative stress and radiation-induced late normal tissue injury: a reviewM E C Robbins
Departments of Radiation Oncology and Neurosurgery, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Int J Radiat Biol 80:251-9. 2004..This mini-review presents data to support this hypothesis and provides the foundation for antioxidant-based interventional approaches directed at modulating late normal tissue injury...
- Radiation-associated cardiovascular diseaseM Jacob Adams
Department of Pediatrics, Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 631, Rochester, NY 14642, USA
Crit Rev Oncol Hematol 45:55-75. 2003..Long-term cardiac follow-up of these patients is therefore essential, and the range of appropriate cardiac screening is discussed, although no specific, evidence-based screening regimen was found in the literature...
- Diabetes mellitus: a predictor for late radiation morbidityD M Herold
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 43:475-9. 1999....
- Correlation of smoking history and other patient characteristics with major complications of pelvic radiation therapy for cervical cancerPatricia J Eifel
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 20:3651-7. 2002..The purpose of this study was to identify patient-related factors that influence the risk of serious late complications of pelvic radiation therapy...
- Priority list of research areas for radiological nuclear threat countermeasuresTerry C Pellmar
Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, Maryland 20889 5603, USA
Radiat Res 163:115-23. 2005....
- Defining the risk of developing grade 2 proctitis following 125I prostate brachytherapy using a rectal dose-volume histogram analysisK M Snyder
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 50:335-41. 2001..Delivered dose should be kept below defined rectal volume thresholds to minimize this risk. This information can allow one to decrease rectal morbidity by modifying prostate implant technique...
- Radioprotectors and mitigators of radiation-induced normal tissue injuryDeborah Citrin
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Oncologist 15:360-71. 2010..Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing...
- Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effectsD P Dearnaley
Academic Department of Radiotherapy and Oncology, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK
Br J Cancer 92:488-98. 2005..Data from this randomised pilot study informed the Data Monitoring Committee of the Medical Research Council RT 01 Trial and the two studies will be combined in subsequent meta-analysis...
- An overview of hypofractionation and introduction to this issue of seminars in radiation oncologyRobert D Timmerman
Semin Radiat Oncol 18:215-22. 2008
- Noncancer disease incidence in atomic bomb survivors, 1958-1998Michiko Yamada
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
Radiat Res 161:622-32. 2004..These results attest to the need for continued follow-up of the aging A-bomb survivors to fully elucidate the effects of radiation exposure on the occurrence of noncancer diseases...
- Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in micePayel Bhanja
Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America
PLoS ONE 4:e8014. 2009....
- Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003Yukiko Shimizu
Department of Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
BMJ 340:b5349. 2010..To investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke...
- Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trialChristopher R King
Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Int J Radiat Oncol Biol Phys 73:1043-8. 2009..The radiobiology of prostate cancer favors a hypofractionated dose regimen. We report results of a prospective Phase II clinical trial of stereotactic body radiotherapy (SBRT) for localized prostate cancer...
- Role of intensity-modulated radiotherapy in reducing toxicity in dose escalation for localized prostate cancerAbrahim Al-Mamgani
Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
Int J Radiat Oncol Biol Phys 73:685-91. 2009....
- Comparison of heart and coronary artery doses associated with intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for distal esophageal cancerThomas P Kole
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Int J Radiat Oncol Biol Phys 83:1580-6. 2012..four-field three-dimensional conformal radiotherapy (3D-CRT) treatment plans for patients with distal esophageal cancer undergoing chemoradiation...
- Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatmentA J Kumar
Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Box 57, Houston, TX 77030, USA
Radiology 217:377-84. 2000..To describe both the common and less frequently encountered magnetic resonance (MR) imaging features of radiation therapy- and chemotherapy-induced brain injury, with particular emphasis on radiation necrosis...
- Intensity-modulated radiotherapy for sinonasal cancer: improved outcome compared to conventional radiotherapyPiet Dirix
Department of Radiation Oncology, Leuvens Kankerinstituut LKI, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
Int J Radiat Oncol Biol Phys 78:998-1004. 2010..To evaluate clinical outcome and toxicity of postoperative intensity-modulated radiotherapy (IMRT) for malignancies of the nasal cavity and paranasal sinuses...
- Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systemsMaaike Berbee
Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Radiat Res 175:297-306. 2011..GT3+PTX did not reduce GI toxicity or vascular oxidative stress compared to GT3 alone. The radioprotective effect of either drug alone or both drugs in combination does not require the presence of eNOS...
- Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinomaYi Jun Hua
State Key Laboratory of Oncology in Southern China, Guangzhou, China
Head Neck 31:807-12. 2009..However, the analysis of PRNN with a significant cohort of patients has not been reported in English-language literature. In this study, we aimed to evaluate PRNN in 28 patients with NPC...
- Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1-3 brain metastases: a feasibility study using volumetric modulated arc therapyFred Hsu
Vancouver Centre, Department of Radiation Oncology, BC Cancer Agency, British Columbia, Canada
Int J Radiat Oncol Biol Phys 76:1480-5. 2010..To evaluate the feasibility of using volumetric modulated arc therapy (VMAT) to deliver whole brain radiotherapy (WBRT) with hippocampal avoidance and a simultaneous integrated boost (SIB) for one to three brain metastases...
- Effects of radiation on normal tissue: consequences and mechanismsHelen B Stone
Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, MD 20892 7440, USA
Lancet Oncol 4:529-36. 2003..Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed. These could greatly improve the quality of life of patients treated for cancer...
- Radiation-induced lung injury. Assessment, management, and preventionPaiman Ghafoori
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Oncology (Williston Park) 22:37-47; discussion 52-3. 2008..New modalities such as intensity-modulated radiation therapy and stereotactic body radiation therapy provide new treatment options but also pose new challenges in safely delivering thoracic RT...
- Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy of non-small cell lung cancer: a dose- and volume-response analysisNiclas Pettersson
Department of Radiophysics, Sahlgrenska University Hospital, Sweden
Radiother Oncol 91:360-8. 2009..The aim of this study is to analyse the dose-response and the volume-response of radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy (SBRT)...
- Three-dimensional conformal radiation therapy for squamous cell carcinoma of the esophagus: a prospective phase I/II studyKai liang Wu
Department of Radiation Oncology, Fudan University Shanghai Cancer Hospital, Shanghai, PR China
Radiother Oncol 93:454-7. 2009..A prospective phase I-II study was conducted to determine the tolerance and local control rate of three-dimensional conformal radiotherapy (3-DCRT) for esophageal squamous cell carcinoma (SCC)...
- Acute toxicity of curative radiotherapy for intermediate- and high-risk localised prostate cancer in the EORTC trial 22991O Matzinger
EORTC Headquarters, Belgium
Eur J Cancer 45:2825-34. 2009..We report acute toxicity (CTCAE v2) assessed weekly during RT in relation to radiation parameters...
- Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of preventionNicolaus Andratschke
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
Radiother Oncol 100:160-6. 2011....
- Radiation dose-volume effects in the stomach and small bowelBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Int J Radiat Oncol Biol Phys 76:S101-7. 2010..Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity...
- Estimation of α/β for late rectal toxicity based on RTOG 94-06Susan L Tucker
Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Int J Radiat Oncol Biol Phys 81:600-5. 2011....
- Review of the cardiac long-term effects of therapy for Hodgkin lymphomaAndrea K Ng
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Br J Haematol 154:23-31. 2011..Screening for and aggressive management of traditional cardiac risk factors are also important strategies in reducing risks of cardiac disease in long-term Hodgkin lymphoma survivors...
- Sparing of the hippocampus, limbic circuit and neural stem cell compartment during partial brain radiotherapy for glioma: a dosimetric feasibility studyJames C Marsh
Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
J Med Imaging Radiat Oncol 55:442-9. 2011..The aim of this study was to assess the feasibility of sparing contralateral or bilateral neural stem cell (NSC) compartment, hippocampus and limbic circuit during partial brain radiotherapy (PBRT)...
- Treatment and prognosis of patients with late rectal bleeding after intensity-modulated radiation therapy for prostate cancerShinya Takemoto
Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Radiat Oncol 7:87. 2012..We evaluated the results of treatment for hemorrhagic proctitis after IMRT for prostate cancer...
- A randomized prospective study of rehabilitation therapy in the treatment of radiation-induced dysphagia and trismusY Tang
Department of Neurology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
Strahlenther Onkol 187:39-44. 2011..To evaluate the therapeutic effect of rehabilitation therapy on radiation-induced dysphagia and trismus in nasopharyngeal carcinoma (NPC) patients after radiotherapy...
- A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancerJames D Murphy
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5152, USA
Int J Radiat Oncol Biol Phys 78:1420-6. 2010..The duodenum is generally considered to be the organ at greatest risk. This study reports on the dosimetric determinants of duodenal toxicity with single-fraction SBRT...
- Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patientsMojgan Taremi
Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
Int J Radiat Oncol Biol Phys 82:967-73. 2012..To present the results of stereotactic body radiotherapy (SBRT) for medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and contrast outcomes in patients with and without a pathologic diagnosis...
- A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposureMark P Little
Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS Comput Biol 5:e1000539. 2009..The analysis of the present paper suggests that linear extrapolation would be appropriate for this endpoint...
- Pregnancy outcome after treatment for Wilms tumor: a report from the national Wilms tumor long-term follow-up studyDaniel M Green
Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Way, Mail Stop 735, Memphis, TN 38105 2794, USA
J Clin Oncol 28:2824-30. 2010....
- Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patientsPedro J Prada
Department of Radiation Oncology, Hospital Central de Asturias, Oviedo, Spain
Int J Radiat Oncol Biol Phys 69:95-102. 2007..We began an investigational trial injecting hyaluronic acid (HA) in the perirectal fat to increase the distance between the prostate and the anterior rectal wall. This is the first report using HA injection in oncology...
- Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapyJames C Marsh
Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
Int J Radiat Oncol Biol Phys 78:946-54. 2010..To assess the feasibility of dosimetrically sparing the hippocampus and neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI)...
- Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literatureLars Budaus
Martini Clinic Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
Eur Urol 61:112-27. 2012..The selection of the optimal RT treatment for the individual is still a point of discussion, and the debate centres on two important outcomes-namely, cancer control and reduction of side-effects...
- Radiotherapy for 41 patients with stages I and II MALT lymphoma: a retrospective studyHideomi Yamashita
Department of Radiology, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
Radiother Oncol 87:412-7. 2008..We analyzed our recent experience with Stage I/II MALT lymphoma presenting in the stomach and other organs to assess the outcome following radiation therapy (RT) alone...
- A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damageIsabel L Jackson
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
Radiat Res 175:510-18. 2011..C57L mice are particularly relevant in that they show significant lung damage at lower radiation doses that are closer to what is predicted for humans...
- Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy aloneShyh An Yeh
Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Int J Radiat Oncol Biol Phys 62:672-9. 2005..The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone...
- Medical radiation exposure in the U.S. in 2006: preliminary resultsFred A Mettler
Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
Health Phys 95:502-7. 2008..Nuclear medicine accounted for about 4% of all procedures but 26% of the total collective dose. Medical radiation exposure is now approximately equal to natural background radiation...
- Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breastsCarsten Nieder
Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
Radiother Oncol 82:301-7. 2007..Especially in highly curable diseases such as lymphoma, long-term survivors might develop late cardiac damage and radiation-induced second cancer...
- Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodesMario Bignardi
Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
Int J Radiat Oncol Biol Phys 75:1570-7. 2009....
- Manifestations and mechanisms of non-targeted effects of ionizing radiationEric G Wright
University of Dundee, Centre for Oncology and Molecular Medicine, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Mutat Res 687:28-33. 2010....
- Volumetric modulated arc therapy for advanced pancreatic cancerWietse Eppinga
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
Strahlenther Onkol 186:382-7. 2010..A planning study evaluated if volumetric modulated arc therapy (RapidArc [RA]) could be used as an alternative to IMRT in such cases...
- High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancerAlvaro A Martinez
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
Am J Clin Oncol 33:481-8. 2010..The 5-year experience at William Beaumont Hospital (WBH) and the California Endocurietherapy Center (CET) with accelerated-hypofractionated high-dose-rate (HDR) monotherapy in favorable prostate cancer is presented...
- Methionine positron emission tomography for differentiation of recurrent brain tumor and radiation necrosis after stereotactic radiosurgery--in malignant gliomaNaohiro Tsuyuguchi
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
Ann Nucl Med 18:291-6. 2004..Following stereotactic radiosurgery (SRS), we examined how to differentiate radiation necrosis from recurrent malignant glioma using positron emission tomography (PET) with 11C-methionine (Met)...
- Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosisJack P Rock
Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
Neurosurgery 51:912-9; discussion 919-20. 2002..Multivoxel proton magnetic resonance spectroscopic imaging ((1)H MRSI) may be reliable in guiding the clinical management of untreated patients; however, its value in managing previously treated patients remains unclear...
- Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancerM Back
Department of Radiation Oncology, The Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
Clin Oncol (R Coll Radiol) 16:12-6. 2004..To document the acute toxicity experienced by women receiving radiation therapy as part of breast-conservation therapy (BCT) for early breast cancer...
- Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factorsIssam El Naqa
Department of Radiation Oncology, Washington University, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 64:1275-86. 2006..Current models are usually oversimplified. We describe alternative methods for building multivariable dose-response models...
- Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a reviewJ E Moulder
Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Int J Radiat Biol 80:3-10. 2004..This review discusses recent advances in the knowledge about how radiation injuries from such events might be treated pharmacologically, and the practical barriers to clinical utilization of ..
- Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapyNeal E Dunlap
University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 76:796-801. 2010..To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy...
- Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancerGary M Freedman
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Am J Clin Oncol 29:66-70. 2006..Our hypothesis is that measures to decrease dose inhomogeneity within the breast and skin with IMRT will improve acute skin toxicity...
- Radiation dose-volume effects in the spinal cordJohn P Kirkpatrick
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 76:S42-9. 2010..However, long-term data are insufficient to calculate a dose-volume relationship for myelopathy when the partial cord is treated with a hypofractionated regimen...
- Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003Helen B Stone
National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 162:711-28. 2004To develop approaches to prophylaxis/protection, mitigation and treatment of radiation injuries, appropriate models are needed that integrate the complex events that occur in the radiation-exposed organism...
- Some novel approaches for radioprotection and the beneficial effect of natural productsDharmendra K Maurya
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Indian J Exp Biol 44:93-114. 2006....
- Treatment of radiation proctitis with argon plasma coagulationW Tam
Dept of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, South Australia, Australia
Endoscopy 32:667-72. 2000..Therapeutic options for this condition are limited. This study was undertaken to evaluate the usefulness of argon plasma coagulation (APC) in the treatment of rectal bleeding due to radiation proctitis...
- Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingRamon F Barajas
Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
Radiology 253:486-96. 2009....
- Carcinoma of paranasal sinuses: long-term outcomes with radiotherapyAngel I Blanco
Department of Radiation Oncology, Washington University, St Louis, MO, USA
Int J Radiat Oncol Biol Phys 59:51-8. 2004..To assess the clinical features, prognostic factors, results, and complications of treatment of carcinomas of the paranasal sinus...
- The autophagy-inducing drug carbamazepine is a radiation protector and mitigatorHyun Kim
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Int J Radiat Biol 87:1052-60. 2011..To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator...
- Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanismsM P Little
Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Norfolk Place, London, W2 1PG, UK
Radiat Environ Biophys 49:139-53. 2010..Although the predictions of the model are consistent with the epidemiological data, the experimental predictions made have yet to be tested. Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
- Evidence-based organ-sparing radiotherapy in head and neck cancerPiet Dirix
Department of Radiation Oncology, Leuven Cancer Institute LKI, Leuven, Belgium
Lancet Oncol 11:85-91. 2010..Because xerostomia and dysphagia are the main causes of decreased quality of life after radiotherapy for head and neck cancer, the prevention of these two complications will form the focus of this review...
- Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrationsEric Bey
hôpital d instruction des armées Percy, Service de Chirurgie Plastique, BP 410, 92141 Clamart Cedex, France
Wound Repair Regen 18:50-8. 2010..The success of this combined treatment leads to new prospects in the medical management of severe radiation burns and more widely in the improvement of wound repair...
- Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosusStephan Meller
Heinrich Heine University, Dusseldorf, Germany
Arthritis Rheum 52:1504-16. 2005..To investigate the activation and recruitment pathways of relevant leukocyte subsets during the initiation and amplification of cutaneous lupus erythematosus (LE)...
- Development of lisinopril for post-exposure mitigation of late effects from a radMEETHA M MEDHORA; Fiscal Year: 2013DESCRIPTION (provided by applicant): Our research goal has been to mitigate radiation injuries to the lungs and kidneys. Mitigation is the use of a countermeasure after exposure to ionizing radiation but before symptoms develop...
- Post-Irradiation Intervention to Mitigate and Treat Non Hematological RadiationJOHN MOULDER; Fiscal Year: 2009..the Center is to develop pharmacologic approaches for the mitigation and treatment of the non-hematological radiation injuries that will occur in victims of radiological terrorism or radiation accidents who receive doses in excess of 5 ..
- Mitigation of Radiation Pneumonitis and FibrosisERIC PHIN COHEN; Fiscal Year: 2013..The broad, long-term objective of our work is to achieve effective and safe mitigation o normal tissue radiation injuries for any tissue type...
- Restoring Immune Function Following Radiation Injuries by TLR9 Agonist TreatmentJames A Lederer; Fiscal Year: 2013..Collectively, the results of these studies will provide pre-clinical data for translating CpG ODNs as effective medical countermeasures for treating to the variety of injuries that could occur following a nuclear event. ..
- ANALYSIS OF RADIATION INJURIES IN 440 OVERDOSED PATIENTSTimothy Schultheiss; Fiscal Year: 1993..taken account of censoring that results from the death of patients prior to and during the period that late radiation injuries are expressed...
- OCULAR MELANOMAPaul Finger; Fiscal Year: 2003..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
- Non-Invasive Localization of Vulnerable PlaquesCynthia McCollough; Fiscal Year: 2009....
- KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPYJOHN MOULDER; Fiscal Year: 2006..These latter findings cast considerable doubt on the standard mechanistic explanations for late radiation injuries, and suggest that injuries caused by radiation therapy, radiation accidents or nuclear terrorism could be ..
- Dose-Volume Modeling of Late Rectal and Bladder ToxicitySusan Tucker; Fiscal Year: 2007..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
- HIGH ENERGY IONS AND GENOMIC INSTABILITYEric Hall; Fiscal Year: 2001....
- The Renin-Angiotensin System, Inflammation and Radiation-induced Brain InjuryMichael E Robbins; Fiscal Year: 2010....
- Hospice Pain Control: Developing an Opioid Order SheetBarbara Murphy; Fiscal Year: 2006..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. [unreadable] [unreadable]..
- Neural Predictors and RAS Modulation of Radiation-induced Cognitive ImpairmentMichael E Robbins; Fiscal Year: 2010..These studies should provide information that is likely to lead to treatments that ameliorate radiation-induced brain injury, including cognitive impairment;thereby, addressing one of NCI's new areas of public health emphasis. ..
- PUFA-MEDIATED MODULATION OF RAT CATALASE EXPRESSIONMichael Robbins; Fiscal Year: 2003....
- NORMAL TISSUE DOSE VOLUME RESPONSE IN RADIATION THERAPYTimothy Schultheiss; Fiscal Year: 2002..This form of data splitting will be used to determine if the model(s) fit the new data, thereby validating the initial results. ..
- RADIATION RESPONSE OF THE NORMAL SUBEPENDYMAJOHN FIKE; Fiscal Year: 2001..abstract_text> ..
- PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURYMichael Robbins; Fiscal Year: 2004..These studies offer the promise of developing rational therapeutic strategies directed at reducing the severity of this dose-limiting morbidity in human beings. ..
- The Brain Tumor Epidemiology Consortium Fall '05 MeetingFaith Davis; Fiscal Year: 2005..This meeting will bring together neuro-pathologists and epidemiologists to address these issues as they pertain to BTEC projects. ..
- Occupational exposures and brain cancerElisabeth Cardis; Fiscal Year: 2010..Further analyses of possible interactions between EMF and specific chemicals will also be conducted. ..
- Role of EETs in Growth of Human Endothelial CellsMeetha Medhora; Fiscal Year: 2006..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
- Eugene P. Cronkite SymposiumNicholas Dainiak; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Comparative DNA Microarray Analysis of Brain TumorsDaniel Brat; Fiscal Year: 2006....
- TIME RELATED FACTORS IN CANCER EPIDEMIOLOGYBryan Langholz; Fiscal Year: 2006..The impact of these projects is to expand the design and analysis "tools"' available to epidemiologic research in a way that will improve validity and cost-efficiency. [unreadable] [unreadable]..
- Non-invasive beta-cell imaging using a Ga-68-labeled glucagone-like peptide-1 anaMartin Gotthardt; Fiscal Year: 2008..Apart from proof-of-principle studies in healthy volunteers and diabetes type I and II patients, a dosimetric method will be established to simply and reliably quantify beta-cell mass by PET imaging. [unreadable] [unreadable]..
- Adolescent daughters' response and adjustment to maternal breast cancerDANUTA CLEMMENS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- US Prostate Cancer Detection with Dutasteride PretreatmentEthan Halpern; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.Daniel J Brat; Fiscal Year: 2010..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
- CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIAJohn E Baker; Fiscal Year: 2010..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
- Molecular Characterization of p53R2 in Head and Neck CaStuart Wong; Fiscal Year: 2004..We will identify and characterize the frequency of p53R2 gene SNPs in HNSCC patients and test the hypothesis that p53R2 gene SNPs predict adverse normal tissue radiation effects in HNSCC patients treated with radiation. ..
- Human Brain Protein MR Imaging and Spectroscopy at 3TJinyuan Zhou; Fiscal Year: 2004..The successful outcome of this application will offer a sensitive and specific modality in the clinical MRI examination of diseases. ..
- Pilot study on the safety and efficacy of ciprofloxacin for prophylactic preventiHans Herfarth; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- P28-DRA IN THE STRESS RESPONSE OF MAMMALIAN CELLSMichael Story; Fiscal Year: 2001..Understanding how p28dra functions will provide new insights into overcoming resistance to cancer therapy and possibly lead to new clinical strategies in cancer management. ..
- Mammography and High-Risk Survivors of Pediatric CancerKevin Oeffinger; Fiscal Year: 2005....
- Outcomes Research and Training in OncologyJames Talcott; Fiscal Year: 2005..One approach to these issues is to identify differences in outcomes based on the mode of diagnosis (screening vs. investigation of symptoms). ..
- Mechanisms and Treatment of Cancer-Related Symptoms ConfCharles Cleeland; Fiscal Year: 2005..The conference should also be of interest to pharmaceutical companies that are developing "pipeline" drugs for symptom control and supportive care. ..
- MR of post traumatic axonal de- and regenerationDavid Hackney; Fiscal Year: 2005..abstract_text> ..
- NUCLEOPROTEINS IN MAMMALIAN SPERMATOGENESISMarvin Meistrich; Fiscal Year: 2006..Thus they provide a well-defined model system for study of human infertility. ..
- Cardiovascular Risk 50 Years After Thymic IrradiationMichael Adams; Fiscal Year: 2007..This group of individuals, if shown to be at high risk, constitutes a potentially huge number of persons who may benefit from additional preventive measures. ..
- Endothelial Dysfunction in Intestinal Radiation ToxicityMartin Hauer Jensen; Fiscal Year: 2009..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
- Radiation injury to the heartJohn E Baker; Fiscal Year: 2010..1 ..
- RADIOTHERAPY EFFECTS ON BRAIN FUNCTIONING IN ADULTSCAROL ARMSTRONG; Fiscal Year: 2001..They will gather pilot data on the sensitivity of MTI to radiation effects in 37 cases during the early and late delayed periods. Standard brain regions, tumor sites and specific regions will be examined. ..
- Imaging Thymidine Uptake During Treatment for Head and Neck CancerYusuf Menda; Fiscal Year: 2008..The studies proposed here will refine and characterize a non-invasive imaging test that may allow treatment responses to be determined shortly after treatment has begun. [unreadable] [unreadable] [unreadable]..
- Assessment of BBB Disruption during RT using DCE MRIYue Cao; Fiscal Year: 2006..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
- Neurogenesis, Inflammation and Irradiation InjuryMICHELLE MONJE DEISSEROTH; Fiscal Year: 2003..abstract_text> ..
- Intravascular Thrombosis in GlioblastomaDaniel Brat; Fiscal Year: 2005..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
- Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic RetinopathyPeter Kaiser; Fiscal Year: 2006..The CAM continues to serve as a convenient testbed for ongoing development of fractal methods and for examination of effects of human regulators on angiogenesis and vascular remodeling. ..
- MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHYMartin Hauer Jensen; Fiscal Year: 2005..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
- Understanding the Impact of Multiple Symptoms: A Symptom Burden ConsortiumCharles Cleeland; Fiscal Year: 2006..The document will be a collaborative effort among consortium participants, and will be submitted to a leading scientific peer-reviewed journal. [unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanisms of Radiation-Induced Genomic IstabilityWilliam Morgan; Fiscal Year: 2005....
- Genetic Reg. of Hematopoietic Stem Cell MobilizationHartmut Geiger; Fiscal Year: 2007..g. to muscle tissue, or to other hematopoietic niches. ..
- Imaging Biomarkers for Cancer Drug DevelopmentALMA SORENSEN; Fiscal Year: 2004..The planning grant revolves around three aims: to confer a multidisciplinary partnership to work towards this goal; to select a set of demonstration projects, and to develop an operating plan for the partnership. ..
- Role of ATM in Radiosensitivity of GliomasChandan Guha; Fiscal Year: 2004..IV) To investigate the combined toxicity of the virus vectors, ATM attenuation and radiation therapy in cultured endothelial cells, astrocytes, oligodendrocytes, neurons and brain tissues in mice models. ..
- BYSTANDER EFFECTS AND X RAY INDUCED GENOMIC INSTABILITYWilliam Morgan; Fiscal Year: 2004..Identifying the BSEF would enhance our understanding of how radiation exerts its deleterious effects and could directly impact risk estimation for radiation exposure. ..
- CHILDRENS CANCER GROUPKatherine Matthay; Fiscal Year: 2002..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
- Sharing canonical human stroke dataOna Wu; Fiscal Year: 2010..Linking our existing portals with BIRN resources has the potential to greatly facilitate data sharing which will benefit the understanding of stroke and speed discovery of new therapeutic interventions. ..
- Imaging Archive for Magnetic Resonance Imaging SystemsALMA SORENSEN; Fiscal Year: 2005..Overall, this needed resource will greatly facilitate many NIH-funded investigators and investigations for years to come. ..
- A 3.0 Tesla MRI System in a Neuroscience ICUALMA SORENSEN; Fiscal Year: 2004..Since these subjects are difficult to bring to the instrumentation, we seek to gain these insights by bringing the instrumentation to them. The proposed instrument will bring state-of-the-art performance to a unique setting. ..
- High Resolution PET Camera for Brain ImagingALMA SORENSEN; Fiscal Year: 2006..Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions. [unreadable] [unreadable]..
- MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKEALMA SORENSEN; Fiscal Year: 2008..unreadable] [unreadable]..
- 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*Katherine Matthay; Fiscal Year: 2004..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
- Silicon Graphics Prism Extreme 128P/1TBALMA SORENSEN; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- 7T Translational MRI SystemALMA SORENSEN; Fiscal Year: 2007..We list 24 funded projects in support of this additional instrumentation. [unreadable] [unreadable] [unreadable]..
- Spatial-Temporal Imaging of Cell Proliferation & HypoxiaRobert Jeraj; Fiscal Year: 2007..unreadable] [unreadable]..
- PROJECT ALLIFE-EXERCISE AND LEUKEMIA SURVIVORSKevin Oeffinger; Fiscal Year: 2006..This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population. ..
- Presurgery Hypnosis in Breast Cancer: Benefits AnalysisGuy Montgomery; Fiscal Year: 2006..Mediators and moderators (e.g., hypnotizability) of hypnosis effects will be determined, as well as long-term side benefits of the intervention. ..
- Accurate Models for Predicting Radiation-Induced InjuryShiva Das; Fiscal Year: 2009..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
- Breast Cancer, Radiation and the ATM-CHEK2 PathwayJonine Bernstein; Fiscal Year: 2008..Conduct a population-based case-control association study of 6 genes involved in the ATM-CHEK2 pathway to determine whether they are associated with an increased risk of radiation-induced contralateral breast cancer. ..
- Presurgery Hypnosis--Benefits Analysis in Breast CancerGuy Montgomery; Fiscal Year: 2003..The possible mediational role of these factors in hypnosis effects will be examined will classic statistical approaches. ..
- ANTICANCER DRUG RESISTANCE BY BCL-2 ONCOGENE EXPRESSIONRaymond Meyn; Fiscal Year: 2007..abstract_text> ..