heat stroke

Summary

Summary: Overexposure to heat or overexertion most common in old age or infancy but especially in the elderly, accompanied by convulsions, delusions, or coma. It is treated by cooling the body and replacing fluids and salts. (From Segen, Dictionary of Modern Medicine, 1992, p282)

Top Publications

  1. ncbi Vulnerability to heat-related mortality: a multicity, population-based, case-crossover analysis
    Massimo Stafoggia
    Department of Epidemiology, Rome E Health Authority, Rome, Italy
    Epidemiology 17:315-23. 2006
  2. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  3. ncbi Prognostic factors in heat wave related deaths: a meta-analysis
    Abderrezak Bouchama
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Arch Intern Med 167:2170-6. 2007
  4. ncbi Impact of regional climate change on human health
    Jonathan A Patz
    Center for Sustainability and the Global Environment SAGE, Nelson Institute for Environmental Studies, University of Wisconsin, 1710 University Avenue, Madison, Wisconsin 53726, USA
    Nature 438:310-7. 2005
  5. ncbi August 2003 heat wave in France: risk factors for death of elderly people living at home
    S Vandentorren
    Department of Environmental Health, French Institute of Public Health Surveillance, Cedex, France
    Eur J Public Health 16:583-91. 2006
  6. doi Heat stroke: role of the systemic inflammatory response
    Lisa R Leon
    U S Army Research Institute of Environmental Medicine, Thermal Mountain Medicine Division, Kansas St, Bldg 42, Natick, MA 01760 5007, USA
    J Appl Physiol (1985) 109:1980-8. 2010
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
  8. ncbi Sheng mai san, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat
    I Y Lee
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan, Republic of China
    Clin Exp Pharmacol Physiol 32:742-8. 2005
  9. ncbi High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Inflamm Res 59:511-8. 2010
  10. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010

Research Grants

Detail Information

Publications252 found, 100 shown here

  1. ncbi Vulnerability to heat-related mortality: a multicity, population-based, case-crossover analysis
    Massimo Stafoggia
    Department of Epidemiology, Rome E Health Authority, Rome, Italy
    Epidemiology 17:315-23. 2006
    ....
  2. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  3. ncbi Prognostic factors in heat wave related deaths: a meta-analysis
    Abderrezak Bouchama
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Arch Intern Med 167:2170-6. 2007
    ..We conducted a meta-analysis of observational studies on risk and protective factors in heat wave-related deaths...
  4. ncbi Impact of regional climate change on human health
    Jonathan A Patz
    Center for Sustainability and the Global Environment SAGE, Nelson Institute for Environmental Studies, University of Wisconsin, 1710 University Avenue, Madison, Wisconsin 53726, USA
    Nature 438:310-7. 2005
    ....
  5. ncbi August 2003 heat wave in France: risk factors for death of elderly people living at home
    S Vandentorren
    Department of Environmental Health, French Institute of Public Health Surveillance, Cedex, France
    Eur J Public Health 16:583-91. 2006
    ..In the long term, building insulation and urban planning must be adapted to provide protection from possible heat waves...
  6. doi Heat stroke: role of the systemic inflammatory response
    Lisa R Leon
    U S Army Research Institute of Environmental Medicine, Thermal Mountain Medicine Division, Kansas St, Bldg 42, Natick, MA 01760 5007, USA
    J Appl Physiol (1985) 109:1980-8. 2010
    b>Heat stroke is a life-threatening illness that is characterized clinically by central nervous system dysfunction, including delirium, seizures, or coma and severe hyperthermia...
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    ..We propose a feed-forward cyclic mechanism that increases the temperature sensitivity of RyR1 activation and underlies heat stroke and sudden death. The cycle eventually produces a myopathy with damaged mitochondria.
  8. ncbi Sheng mai san, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat
    I Y Lee
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan, Republic of China
    Clin Exp Pharmacol Physiol 32:742-8. 2005
    ..whether Sheng mai san (SMS), a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke by reducing iNOS-dependent nitric oxide (NO) and peroxynitrite formation. 2...
  9. ncbi High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Inflamm Res 59:511-8. 2010
    ..Nevertheless, as heat stroke is a severe inflammatory response disease, we hypothesized that AT III would inhibit inflammation and prevent ..
  10. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..As TM exhibited a strong anti-inflammatory effect in a rat model of acute inflammation induced by heat stress, TM represents a potential therapeutic for heatstroke prevention or management in patients...
  11. doi Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model
    George T Roberts
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Arterioscler Thromb Vasc Biol 28:1130-6. 2008
    ..Severe heatstroke is a leading cause of morbidity and mortality during heat waves. The pathogenesis of tissue injury, organ failure, and death in heatstroke is not well understood...
  12. doi Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model
    Lisa R Leon
    U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, Massachusetts 01760 5007, USA
    Am J Physiol Regul Integr Comp Physiol 299:R241-8. 2010
    ..Taken together, T(c) responses of mild and severe HS mice suggest a need for reinterpretation of the mechanisms of thermoregulatory control during recovery...
  13. doi The effects of temperature and use of air conditioning on hospitalizations
    Bart Ostro
    California Environmental Protection Agency, Oakland, USA
    Am J Epidemiol 172:1053-61. 2010
    ..cardiovascular disease, ischemic heart disease, ischemic stroke, respiratory disease, pneumonia, dehydration, heat stroke, diabetes, and acute renal failure, with a 10°F increase in same-day apparent temperature...
  14. pmc Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke
    Feliciano Protasi
    Centro Scienze dell Invecchiamento, Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, Chieti, Italy
    J Physiol 587:3095-100. 2009
    Malignant hyperthermia (MH) and exertional/environmental heat stroke (EHS) in humans present as similar life threatening crises triggered by volatile anaesthetics and strenuous exercise and/or high temperature, respectively...
  15. ncbi Syndromic surveillance use to detect the early effects of heat-waves: an analysis of NHS direct data in England
    G S Leonardi
    Health Protection Agency Chemical Hazards and Poisons Division Headquarters, Oxon, Great Britain
    Soz Praventivmed 51:194-201. 2006
    ..To investigate the effects of high ambient temperatures, including the summer 2003 heat-episode, on NHS Direct usage and its suitability as a surveillance tool in heat health warning systems...
  16. pmc Unprecedented heat-related deaths during the 2003 heat wave in Paris: consequences on emergency departments
    Jean Francois Dhainaut
    Professor, Emergency and Intensive Care Department, Cochin Port Royal University Hospital, AP HP, University Paris 5, France
    Crit Care 8:1-2. 2004
    ..Indeed, simple preventice measures before hospital admissions are only able to reduce mortality which mostly occurred at home and in nursing homes...
  17. ncbi Heatwaves and public health in Europe
    R Sari Kovats
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Eur J Public Health 16:592-9. 2006
    ..Including evaluation criteria in the design of heatwave early warning systems will help ensure effective and efficient system operation...
  18. ncbi Bilateral hippocampal hyperintensities: a new finding in MR imaging of heat stroke
    Praharaju Janaki Sudhakar
    Department of Radiology, Salmaniya Medical Complex, Manama, Kingdom of Bahrain
    Pediatr Radiol 37:1289-91. 2007
    We present a child aged 2 years 3 months who suffered heat stroke after being accidentally locked in a car during summer...
  19. ncbi Heat stroke: a comprehensive review
    Theresa Pluth Yeo
    The Johns Hopkins University School of Nursing, 525 N Wolfe St, Rm 457, Baltimore, MD 21030, USA
    AACN Clin Issues 15:280-93. 2004
    b>Heat stroke (HS) is a serious and potentially life-threatening condition defined as a core body temperature >40.6 degrees C...
  20. ncbi Heat-related deaths are largely due to brain damage
    H S Sharma
    Indian J Med Res 121:621-3. 2005
  21. ncbi Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon, France
    Laurent Argaud
    Service de Reanimation Medicale, Groupement Hospitalier Edouard Herriot, 5 Place d Arsonval, Lyon Cedex 03, France
    Arch Intern Med 167:2177-83. 2007
    ..Heatstroke is the most severe form of heat-related illness. The clinical course of heatstroke in urban areas of temperate countries is poorly documented...
  22. ncbi [Heat stroke in hospital patients during the summer 2003 heat wave: a nosocomial disease]
    Claire Ferron
    Service d accueil des urgences, Centre Hospitalier et Universitaire de Nantes
    Presse Med 35:196-9. 2006
    We investigated patients who died in our institution during the August 2003 heat wave, to determine whether some in hospital patients actually died of heat stroke.
  23. pmc Local heat stroke prevention plans in Japan: characteristics and elements for public health adaptation to climate change
    Gerardo Sanchez Martinez
    Basque Centre for Climate Change, 4 Alameda Urquijo, Bilbao Vizcaya 48008, Spain
    Int J Environ Res Public Health 8:4563-81. 2011
    ..It can also provide useful elements for municipal governments in vulnerable areas, both in planning their climate change and health adaptation activities or to better protect their communities against current health effects from heat...
  24. pmc Heat wave morbidity and mortality, Milwaukee, Wis, 1999 vs 1995: an improved response?
    Marc G Weisskopf
    Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Public Health 92:830-3. 2002
    ....
  25. ncbi Experimental heatstroke in baboon: analysis of the systemic inflammatory response
    Abderrezak Bouchama
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Shock 24:332-5. 2005
    ..Further definition of this ambivalent response is needed before identification of target of successful modulation may become possible...
  26. ncbi Brain damage after heat stroke
    Céline Bazille
    Service Central d Anatomie et de Cytologie Pathologiques, Hopital Lariboisiere, Paris, France
    J Neuropathol Exp Neurol 64:970-5. 2005
    ..We studied 3 patients (a 74-year-old woman, a 63-year-old man, and an 80-year-old man) who had heat stroke during heat waves in France. One patient had generalized seizures and died 28 hours after admission...
  27. ncbi Classic heat stroke in a case of simple hypohydrosis with "bad prognostic indicators" but a remarkable recovery
    A K Sinha
    Renal Unit, Department of Medicine, Dammam Central Hospital, Saudi Arabia
    Ren Fail 23:727-30. 2001
    b>Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy...
  28. doi Danaparoid sodium attenuates the effects of heat stress
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:762-8. 2011
    b>Heat stroke is a condition characterized by high body temperature that can lead to hemorrhage and necrosis in multiple organs...
  29. ncbi A noninvasive investigation of muscle energetics supports similarities between exertional heat stroke and malignant hyperthermia
    D Bendahan
    , , Marseille, France
    Anesth Analg 93:683-9. 2001
    Exertional heat stroke (EHS) is usually triggered by strenuous exercise performed under hot and humid environmental conditions...
  30. ncbi Role of endotoxin and cytokines in the systemic inflammatory response to heat injury
    Lisa R Leon
    Thermal Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Building 42, Natick, Massachusetts 01760 5007, USA
    Front Biosci (Schol Ed) 2:916-38. 2010
    Environmental heat exposure represents one of the most deadly natural hazards in the United States. Heat stroke is a life-threatening illness that affects all segments of society with few effective treatment strategies to mitigate the ..
  31. pmc The relation between ambulance transports stratified by heat stroke and air temperature in all 47 prefectures of Japan in August, 2009: ecological study
    Nobuyuki Miyatake
    Department of Hygiene, Faculty of Medicine, Kagawa University, 1750 1, Miki, Kagawa, 761 0793, Japan
    Environ Health Prev Med 17:77-80. 2012
    Our aim was to investigate the link between ambulance transports stratified by heat stroke and air temperature in August 2009 in Japan.
  32. pmc Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?
    Kilian Weigand
    Department of Gastroenterology and Hepatology, Medicine IV, University of Heidelberg, 69120 Heidelberg, Germany
    World J Gastroenterol 13:306-9. 2007
    ..cardiopulmonary symptoms are common in patients undergoing classical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon...
  33. pmc Growing concern about heatstroke this summer in Japan after Fukushima nuclear disaster
    Masahide Kondo
    Department of Health Care Policy and Management, University of Tsukuba, Ibaraki, Japan
    Environ Health Prev Med 16:279-80. 2011
    b>Heat stroke management will be a major challenge following the Fukushima nuclear plant accident that occurred due to the Great East Japan Earthquake. In this article, a number of actions to meet this challenge are proposed.
  34. pmc Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave
    Pierre Hausfater
    Emergency Department Hôpital Pitié Salpêtrière et Université Pierre et Marie Curie Paris 6, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Crit Care 14:R99. 2010
    ..The prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented...
  35. ncbi Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons
    Abderrezak Bouchama
    Departments of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Shock 27:578-83. 2007
    ..These results do not support clinical testing of corticosteroids as beneficial in preventive or therapeutic strategies for the treatment of heatstroke in humans...
  36. ncbi Gray-white matter discrimination--a possible marker for brain damage in heat stroke?
    Oded Szold
    General Intensive Care Unit, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv, Israel
    Eur J Radiol 43:1-5. 2002
    b>Heat stroke (HS) is a common medical emergency which carries high morbidity and morality...
  37. ncbi Diffusion-weighted magnetic resonance imaging of a severe heat stroke patient complicated with severe cerebellar ataxia
    Ryusuke Ookura
    Department of Emergency Medicine, Kobe City Medical Center West Hospital, Kobe
    Intern Med 48:1105-8. 2009
    A 78-year-old woman was admitted for severe heat stroke with brain damage. She was unconscious on arrival at the emergency room. Her armpit temperature was 42.0 degrees C and blood pressure was 76/25 mmHg...
  38. ncbi Hypothermia following exertional heat stroke treatment
    Chen Makranz
    The Institute of Military Physiology, Israel Defense Forces, Medical Corps, Tel Hashomer, Israel
    Eur J Appl Physiol 111:2359-62. 2011
    Exertional heat stroke (EHS) is a life-threatening condition, which deteriorates rapidly. Immediate cooling treatment can, therefore, be life saving...
  39. ncbi [Evaluation of the impact of the heat wave in the summer of 2003 on mortality]
    Ferran Martínez Navarro
    Centro Nacional de Epidemiologia, Madrid, Spain
    Gac Sanit 18:250-8. 2004
    ..Alert and response systems based on monitoring of climate related risks, emergency rooms activity and mortality and the strengthening of social and health services response capacity should be considered...
  40. ncbi [Effect of weather temperature on hospital emergencies in the Region of Murcia, Spain, throughout the 2000-2005 and its use in epidemiological surveillance]
    Rocío García-Pina
    Servicio de Epidemiologia, Consejería de Sanidad de Murcia, Murcia, Spain
    Rev Esp Salud Publica 82:153-66. 2008
    ..In Murcia, the number of daily emergencies and the cases of heat stroke for which care is provided at the hospitals in this Region have been studied.
  41. pmc Temperature and air pollution as risk factors for heat stroke in Tokyo, July and August 1980-1995
    W T Piver
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 107:911-6. 1999
    b>Heat stroke is associated with prolonged exposures to high air temperatures that usually occur in the summer months of July and August in Tokyo, Japan...
  42. ncbi Heat wave 2003 and mortality in Switzerland
    Leticia Grize
    Institute of Social and Preventive Medicine, University of Basel
    Swiss Med Wkly 135:200-5. 2005
    ..This is the first analysis investigating whether the high temperatures during summer 2003 in Switzerland had a measurable impact on mortality...
  43. pmc Municipal heat wave response plans
    Susan M Bernard
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Public Health 94:1520-2. 2004
    ..In a review of plans from 18 cities at risk for heat-related mortality, we found that many cities had inadequate or no heat response plans. This is an important area for further investigation and government attention...
  44. ncbi Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury
    Ruben A Mota
    Department of Surgery, Hospital Virgen de la Arrixaca, CIBERehd, Murcia, Spain
    Crit Care Med 36:526-34. 2008
    b>Heat stroke is a life-threatening illness characterized by an increased core body temperature as a result of exposure to high ambient temperature...
  45. ncbi Fatal exertional heat stroke: a case series
    Moshe Rav-Acha
    Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    Am J Med Sci 328:84-7. 2004
    Exertional heat stroke (EHS) is one of the most serious conditions that occur when excess heat, generated by muscular exercise, exceeds the body's heat-dissipation rate...
  46. ncbi Brain cooling causes attenuation of cerebral oxidative stress, systemic inflammation, activated coagulation, and tissue ischemia/injury during heatstroke
    Shu Fen Hsu
    Institute of Physiology, National Yang Ming University School of Medicine, Taipei, Taiwan 112
    Shock 26:210-20. 2006
    ....
  47. doi Heat stress disorders and headache: a case of new daily persistent headache secondary to heat stroke
    C Di Lorenzo
    J Neurol Neurosurg Psychiatry 79:610-1. 2008
  48. ncbi Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Shock 25:295-9. 2006
    ..Enhanced expression of HSP-70 may be an important mechanism leading to enhanced survival via GLN. These data indicate that oral GLN may useful in prevention of mortality from heatstroke in at risk populations...
  49. ncbi Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke
    W C Lee
    Division of Biotechnology, Animal Technology Institute Taiwan, Miaoli, Taiwan
    J Appl Physiol (1985) 100:2073-82. 2006
    ..These results demonstrate that the overexpression of HSP72 in multiple organs improves survival during heatstroke by reducing hyperthermia, circulatory shock, and cerebral ischemia and damage in mice...
  50. ncbi Hyperbaric oxygen improves survival in heatstroke rats by reducing multiorgan dysfunction and brain oxidative stress
    Kou Chi Niu
    Institute of Undersea and Hyperbaric Oxygen Medicine, National Defense Medical Center, Taipei, 116 Taiwan
    Eur J Pharmacol 569:94-102. 2007
    ..The current results indicate that hyperbaric oxygen therapy may resuscitate rats that had a heatstroke by decreasing multiple organ dysfunction and brain oxidative stress...
  51. ncbi Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study
    Benoit Misset
    Intensive Care Unit, Fondation Hopital Saint Joseph, Paris, France
    Crit Care Med 34:1087-92. 2006
    ..We examined the prognosis and risk factors for hospital mortality in patients with heatstroke admitted to an intensive care unit (ICU) during the heat wave in France in August 2003...
  52. ncbi Shengmai San, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation
    Nien Lu Wang
    Institute of Physiology, National Yang Ming University Medical School, Taipei 112, Taiwan
    J Pharmacol Sci 98:1-7. 2005
    ..nitric oxide (NO) in the brain and inflammatory cytokines in the peripheral blood exhibited during heat stroke can be reduced by prior administration of Shengmai San, a Chinese herbal medicine...
  53. ncbi Heat illness and heat stroke
    David S Jardine
    Children s Hospital, Seattle, WA, USA
    Pediatr Rev 28:249-58. 2007
  54. ncbi Is previous thoracic sympathectomy a risk factor for exertional heat stroke?
    Alan D L Sihoe
    Division of Cardiothoracic Surgery, Department of Surgery, The University of Hong Kong, Grantham Hospital, Hong Kong SAR, China
    Ann Thorac Surg 84:1025-7. 2007
    We report the case of a physically fit young man who presented with severe, life-threatening heat stroke after running a 10 km road race...
  55. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
    ..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
  56. ncbi Resuscitation from experimental heatstroke by transplantation of human umbilical cord blood cells
    Sheng Hsien Chen
    Institute of Clinical Medicine, School of Medicine, National Cheng Kung University, Chi Mei Medical Center, Tainan, Taiwan
    Crit Care Med 33:1377-83. 2005
    ..In the study described herein, we administered HUCBCs into the femoral vein or directly into the cerebral ventricular system and assessed their effects on circulatory shock, cerebral ischemia, and damage during heatstroke...
  57. doi Premarin can act via estrogen receptors to rescue mice from heatstroke-induced lethality
    Kun Hung Shen
    Department of Urology, Chi Mei Medical Center, Tainan, Taiwan
    Shock 30:668-74. 2008
    ..The data indicate that Premarin may act via ERs to rescue mice form HS-induced lethality...
  58. ncbi Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms
    Saurabh Chatterjee
    Immunology and Hyperthermia Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    Shock 24:341-7. 2005
    b>Heat stroke-induced death is a major killer worldwide. Mice were subjected to acute heat stress by exposing them to whole-body hyperthermia (WBH) treatment and were used as a model to study heat stroke...
  59. ncbi Oxidative stress and ischemic injuries in heat stroke
    Chen Kuei Chang
    Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    Prog Brain Res 162:525-46. 2007
    ..g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide ..
  60. pmc Predictors of multi-organ dysfunction in heatstroke
    G M Varghese
    Christian Medical College, Vellore, Department of Medicine Unit 2, Vellore, India, 632004
    Emerg Med J 22:185-7. 2005
    ..It carries a high mortality rate, and in survivors, a risk of permanent neurological damage...
  61. ncbi Echocardiographic and Doppler study of patients with heatstroke and heat exhaustion
    M S Shahid
    Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Int J Card Imaging 15:279-85. 1999
    ..Signs of peripheral vasoconstriction were more often present in patients with heatstroke, while patients with heat exhaustion more often demonstrated peripheral vasodilatation...
  62. ncbi Heat stroke and cytokines
    Lisa R Leon
    US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
    Prog Brain Res 162:481-524. 2007
    b>Heat stroke is a life-threatening illness that affects all segments of society, including the young, aged, sick, and healthy...
  63. ncbi Heat shock pretreatment may protect against heatstroke-induced circulatory shock and cerebral ischemia by reducing oxidative stress and energy depletion
    Jui Ling Wang
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Shock 23:161-7. 2005
    ..These results suggest that heat shock pretreatment induces HSP72 overexpression in striatum and confers protection against heatstroke-induced striatal ischemia and damage by reducing oxidative stress and energy depletion...
  64. ncbi Activated protein C therapy in a rat heat stroke model
    Chin Ming Chen
    Department of Critical Care Medicine, Mei Medical Center, Tainan, Taiwan
    Crit Care Med 34:1960-6. 2006
    To evaluate the therapeutic effects of activated protein C in an animal model of heat stroke.
  65. ncbi Heat stroke : a review of cooling methods
    Eran Hadad
    Sheba Medical Center, Heller Institute of Medical Research, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Sports Med 34:501-11. 2004
    The prognosis of heat stroke in patients is directly related to the degree of hyperthermia and its duration. Therefore, the most important feature in the treatment of heat stroke is rapid cooling...
  66. ncbi Heat stroke: implications for critical care and anaesthesia
    H Grogan
    Department of Anaesthesia, Leeds Teaching Hospital Trust, UK
    Br J Anaesth 88:700-7. 2002
  67. ncbi Activated protein C can be used as a prophylactic as well as a therapeutic agent for heat stroke in rodents
    Xiao Jing Lin
    Rehabilitation Department of Spinal Cord Injury, General Hospital Jinan Military, Shandong, China
    Shock 32:524-9. 2009
    ..therapeutic effect of human recombinant activated protein C (APC; drotrecogin-alpha, activated) in experimental heat stroke. Anesthetized rats were divided into two groups and given vehicle solution 1 h before the start or immediately ..
  68. doi Early organ dysfunction course, cooling time and outcome in classic heatstroke
    Sebastian Pease
    Medical Intensive Care Unit, AP HP, Hopital Bichat Claude Bernard, 75018 Paris, France
    Intensive Care Med 35:1454-8. 2009
    ..To describe the course of early organ dysfunction in a cohort of patients admitted in ICU suffering classic heatstroke...
  69. ncbi Human umbilical cord blood-derived CD34+ cells cause attenuation of multiorgan dysfunction during experimental heatstroke
    Sheng Hsien Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Shock 27:663-71. 2007
    ..Our data indicate that CD34+ cell therapy may resuscitate persons who had a heatstroke by reducing multiorgan dysfunction or failure...
  70. ncbi Transient cardiac dysfunction and pulmonary edema in exertional heat stroke
    Shaul Atar
    Department of Cardiology, Cardiac Intensive Care Unit, Ha Emek Medical Center, Afula 18101, Israel
    Mil Med 168:671-3. 2003
    Exertional heat stroke is a medical emergency that uncommonly results in severe cardiac dysfunction. The military physician diagnosed a 19-year-old military recruit from an elite unit to have exertional heat stroke...
  71. ncbi MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury
    Carol T McLaughlin
    Department of Health Education and Training, Tripler Army Medical Center, Honolulu, HI 96859, USA
    AJNR Am J Neuroradiol 24:1372-5. 2003
    ..thalamus and external capsule) and cerebellum on both T1- and T2-weighted images in a patient with documented heat stroke. An ischemic and hemorrhagic mechanism is proposed, and the contributions of the direct effects of hyperthermia ..
  72. ncbi Oxidative stress in rats with heatstroke-induced cerebral ischemia
    Chih Ya Yang
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan, Republic of China
    Stroke 33:790-4. 2002
    ..These factors are known to increase free radical production. This study attempted to ascertain whether an excessive accumulation of cytotoxic free radicals in the brain and oxidative stress can occur during heatstroke...
  73. pmc Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Br J Sports Med 41:597-602. 2007
    ..In the rat brain, heat-stroke-induced damage to cerebral neurons is attenuated through heat-shock-induced overexpression of heat-shock protein 72 (HSP72)...
  74. ncbi Heat-related mortality during a 1999 heat wave in Chicago
    Mary P Naughton
    Epidemic Intelligence Service, Epidemiology Progam Office, and the National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Prev Med 22:221-7. 2002
    ..The high mortality, exceeded only by a 1995 heat wave, provided the opportunity to investigate the risks associated with heat-related deaths and to examine the effectiveness of targeted heat-relieving interventions...
  75. ncbi Hypothermia attenuates circulatory shock and cerebral ischemia in experimental heatstroke
    Yueh Ting Chou
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Shock 19:388-93. 2003
    ..The values of MAP and CBF after the onset of heat stroke in heatstroke rats received no cooling were all significantly lower than those in control rats...
  76. pmc Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke
    Zhih Cherng Chen
    Section of General Medicine, Chi Mei Medical Center, Tainan, Taiwan, Republic of China
    BMC Neurosci 10:111. 2009
    ....
  77. ncbi A hyperbaric oxygen therapy approach to heat stroke with multiple organ dysfunction
    Ko Chi Niu
    Department of Biotechnology, Southern Taiwan University, Department of Hyperbaric Oxygen, Chi Mei Medical Center, Tainan, Taiwan, Republic of China
    Chin J Physiol 52:169-72. 2009
    Here in we report the case of a patient who displayed a classic heat stroke with multiple organ dysfunction and hypercoagulable state resistant to conventional whole body cooling and antipyretic therapy, and necessitating the use of ..
  78. ncbi Resuscitation from experimental heatstroke by brain cooling therapy
    Sheng Huang Hsiao
    Institute of Physiology, National Yang Ming University School of Medicine, Taipei 110, Taiwan
    Resuscitation 73:437-45. 2007
    ....
  79. ncbi Leukocyte activation: the link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris
    Marie Genevieve Huisse
    Department of Hematology, AP HP, Hospital Bichat, Paris, France
    Crit Care Med 36:2288-95. 2008
    ..Here, we examined the roles of the tissue factor pathway, leukocyte activation, and mediators of innate immunity in patients admitted to an intensive care unit for heatstroke during an intense heat wave in Paris...
  80. doi Protection in rats with heatstroke: hyperbaric oxygen vs activated protein C therapy
    Chao Hung Yeh
    Department of Surgery Chi Mei Medical Center, Tainan, Taiwan
    Eur J Pharmacol 635:103-8. 2010
    ..The results indicate consequently, combined activated protein C and hyperbaric oxygen therapy heightens benefit in combating heatstroke reactions...
  81. ncbi Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: role of Th1/Th2 cytokine balance
    Saurabh Chatterjee
    Immunology and Hyperthermia Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    Nitric Oxide 15:408-16. 2006
    ..These results suggest that therapeutic administration of L-arg at appropriate concentration and time attenuates the acute inflammatory response, leading to the rescue of mice from heatstroke...
  82. ncbi Exertional heat stroke in a young man with a documented rise in troponin I
    R Whiticar
    Emergency Department, Wycombe General Hospital, High Wycombe, UK
    Emerg Med J 25:283-4. 2008
    b>Heat stroke is a medical emergency that requires immediate attention to prevent multiorgan dysfunction...
  83. ncbi Aminoguanidine protects against intracranial hypertension and cerebral ischemic injury in experimental heatstroke
    Ching Ping Chang
    Institute of Physiology, National Yang Ming University Medical School, Taipei, Taiwan
    J Pharmacol Sci 95:56-64. 2004
    ..These results suggest that aminoguanidine protects against heatstroke-induced intracranial hypertension and cerebral ischemic injury by inhibition of cerebral iNOS-dependent NO production...
  84. ncbi [The heat wave in France in August 2003]
    D Hemon
    Rev Epidemiol Sante Publique 52:3-5. 2004
  85. ncbi Resuscitation from experimental heatstroke by hyperbaric oxygen therapy
    Hsin Mao Tsai
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Crit Care Med 33:813-8. 2005
    ..Hyperbaric oxygen (HBO) has been shown to reduce brain ischemia and behavioral dysfunction during cerebral artery occlusion. The efficacy of HBO therapy for resuscitation from heatstroke remains to be determined in the laboratory...
  86. doi Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke
    Kun Hung Shen
    Department of Urology, Taipei Medical University, Taipei, Taiwan
    Eur J Appl Physiol 103:561-8. 2008
    ..The results indicate that IL-1ra therapy may restore tissue blood flow and homeostatic function, and limit multiorgan dysfunction and death in heatstroke...
  87. ncbi Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke
    Cheng Kuei Chang
    Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan
    Curr Med Chem 13:3145-54. 2006
    ....
  88. ncbi Role of circulating cytokines and chemokines in exertional heatstroke
    Kuo Cheng Lu
    Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Crit Care Med 32:399-403. 2004
    ..The interplay between inflammatory and anti-inflammatory cytokines, as well as chemokines, has not been well explored in exertional heatstroke...
  89. ncbi Cerebrovascular dysfunction is an attractive target for therapy in heat stroke
    Sheng Hsien Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan
    Clin Exp Pharmacol Physiol 33:663-72. 2006
    ..of animal models that advance the knowledge of the attenuation of cerebrovascular dysfunction in the setting of heat stroke. It is a narrative review of selected published literature from Medline over the period 1959-2005. 2...
  90. ncbi Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke
    Bor Chih Cheng
    Division of Cardiology, Chi Mei Medical Center, Tainan 710, Taiwan
    Neuropharmacology 52:297-305. 2007
    ..The data show that reduction of nNOS-dependent NO(2)(-) with 7-NI causes attenuation of cerebrovascular dysfunction, hyperthermia, and TNF-alpha overproduction during heatstroke in the rat...
  91. pmc Case report: severe heat stroke with multiple organ dysfunction - a novel intravascular treatment approach
    Gregor Broessner
    Department of Neurology, Neurological Intensive Care Unit, Medical University, Innsbruck, Austria
    Crit Care 9:R498-501. 2005
    We report the case of a patient who developed a severe post-exertional heat stroke with consecutive multiple organ dysfunction resistant to conventional antipyretic treatment, necessitating the use of a novel endovascular device to ..
  92. ncbi Endovascular hypothermia for heat stroke: a case report
    Bruno Megarbane
    Intensive Care Med 30:170. 2004
  93. ncbi Exertional heat stroke: a case series
    Y Epstein
    IDF Institute of Military Physiology, Sheba Medical Center, Tel Hashomer, Israel
    Med Sci Sports Exerc 31:224-8. 1999
    Exertional heat stroke (EHS) is a state of extreme hyperthermia that occurs when excess heat that is generated by muscular exercise exceeds the body's ability to dissipate it at the same rate...
  94. ncbi Antithrombin and near-fatal exertional heat stroke
    Ch Pechlaner
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck
    Acta Med Austriaca 29:107-11. 2002
    Heat waves result in excess deaths, excess emergency department visits, and intensive care unit admissions for heat stroke. We describe the clinical features and 3-month outcome of a patient with near-fatal heat stroke, admitted to our ..
  95. ncbi Synergistic effects of ethanol and hyperthermia on carotid artery vasoconstriction
    S Mustafa
    College of Health Sciences, The Public Authority for Applied Education and Training, Safat, Kuwait
    Clin Physiol Funct Imaging 27:185-90. 2007
    ..It was our objective to test the influence of ethanol on cerebral perfusion at normal and higher temperatures...
  96. ncbi Mu-opioid receptor blockade protects against circulatory shock and cerebral ischemia during heatstroke
    Zhih Cherng Chen
    Department of Cardiology, Chi Mei Medical Center, Tainan, Taiwan
    J Cardiovasc Pharmacol 46:754-60. 2005
    ..The data indicate that prior antagonism of mu-opioid receptors protects against circulatory shock and cerebral ischemia during heatstroke...
  97. ncbi Carbon dioxide and pH effects on temperature-sensitive and -insensitive hypothalamic neurons
    Chadwick L Wright
    Department of Physiology and Cell Biology, 201 Hamilton Hall, Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    J Appl Physiol 102:1357-66. 2007
    ..e., increased CO(2) and normal pH). These findings may offer a neural explanation for some heat-related illnesses (e.g., exertional heat stroke) where impaired heat loss is associated with acidosis.
  98. ncbi Effect of glucocorticoid depletion on heat-induced Hsp70, IL-1beta and TNF-alpha gene expression
    Virginie Michel
    Centre de Recherches du Service de Santé Emile Pardé, Département des Facteurs Humains, F 38702 La Tronche France
    Brain Res 1164:63-71. 2007
    ....
  99. ncbi Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke
    Ching Ping Chang
    Department of Biotechnology, Southern Taiwan University of Technology, Tainan, Taiwan 710
    Shock 24:336-40. 2005
    ....
  100. ncbi Platonin, a cyanine photosensitizing dye, is effective for attenuation of heatstroke in rats
    Cheng Chia Tsai
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Shock 26:601-7. 2006
    ..The results demonstrate that platonin is effective for attenuation of heatstroke reactions...
  101. ncbi Infusion of human umbilical cord blood cells protect against cerebral ischemia and damage during heatstroke in the rat
    S H Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Exp Neurol 199:67-76. 2006
    ..These findings indicate that HUCBC transplantation, in addition to having therapeutic values, can be a good choice for preventing heatstroke occurrence...

Research Grants78

  1. HEAT STROKE & HYPERTHERMIA--APPLIED MOLECULAR MECHANISMS
    Pope Moseley; Fiscal Year: 2000
    ..b>Heat stroke is the most catastrophic form of thermal injury and is characterized by cardiovascular collapse and multi-organ ..
  2. HEAT SHOCK PROTEIN REGULATION WITH STRESS AND AGING
    KEVIN KREGEL; Fiscal Year: 2001
    ..in the aged population. The results of this research will help us to design new therapies to protect the elderly against situations involving physiological stress, and potentially, a variety of diseases associated with aging. ..
  3. MECHANISM OF CIRCULATORY INSUFFICIENCY IN HEAT STROKE
    CARL GISOLFI; Fiscal Year: 1991
    ..Moreover, classical heat stroke killed hundreds of people in the USA and Greece during the heat waves of 1987...
  4. Redox Signalling by Nitric Oxide in Skeletal Muscle
    Jonathan S Stamler; Fiscal Year: 2010
    ..pathophysiology of a range of disease states including diaphragmatic dysfunction, malignant hypothermia, and heat stroke, in which the RyR plays a central role, as well as muscular dystrophies in which NO production is dysregulated...
  5. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2010
    ..serotonin syndrome;cocaine toxicity, neuroleptic malignant syndrome;dysautonomia from brain injury, and heat stroke. PUBLIC HEALTH RELEVANCE: Abuse of the amphetamine 3,4-methylenedoxymethamphetamine (ecstasy, MDMA) can result ..
  6. COCAINE ABUSE & EXERCISE INDUCED HEATSTROKE
    PETER LOMAX; Fiscal Year: 1990
    ....
  7. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2001
    ..that receives numerous pharmacological therapies that may predispose them to iatrogenic heat intolerance, heat stroke, and death. The following specific aims will be explored...
  8. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2002
    ..that receives numerous pharmacological therapies that may predispose them to iatrogenic heat intolerance, heat stroke, and death. The following specific aims will be explored...
  9. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2000
    ..that receives numerous pharmacological therapies that may predispose them to iatrogenic heat intolerance, heat stroke, and death. The following specific aims will be explored...
  10. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2003
    ..that receives numerous pharmacological therapies that may predispose them to iatrogenic heat intolerance, heat stroke, and death. The following specific aims will be explored...
  11. HEAT SHOCK PROTEIN REGULATION WITH STRESS AND AGING
    KEVIN KREGEL; Fiscal Year: 1999
    ..in the aged population. The results of this research will help us to design new therapies to protect the elderly against situations involving physiological stress, and potentially, a variety of diseases associated with aging. ..
  12. HEAT SHOCK PROTEIN REGULATION WITH STRESS AND AGING
    KEVIN KREGEL; Fiscal Year: 2000
    ..in the aged population. The results of this research will help us to design new therapies to protect the elderly against situations involving physiological stress, and potentially, a variety of diseases associated with aging. ..
  13. EXERCISE HEAT & THERMOTOLERANCE--MOLECULAR MECHANISMS
    Pope Moseley; Fiscal Year: 1991
    ..Using the rat heat stroke model, we will determine 1) the effects of exercise-induced heat stress compared with passive heat stress on ..
  14. Heat Stroke & Hyperthermia: Applied Molecular Mechanisms
    Pope Moseley; Fiscal Year: 2002
    ....
  15. Mechanisms of Fever-Enhanced Acute Lung Injury
    Jeffrey Hasday; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE. Exposure to elevated body temperatures as occurs during fever or heat stroke changes the blood vessels and white blood cells to increase movement of white blood cells from the blood to the ..
  16. Heat Stroke & Hyperthermia: Applied Molecular Mechanisms
    Pope Moseley; Fiscal Year: 2005
    ....
  17. Heat Stroke & Hyperthermia: Applied Molecular Mechanisms
    Pope Moseley; Fiscal Year: 2004
    ....
  18. Heat Stroke & Hyperthermia: Applied Molecular Mechanisms
    Pope Moseley; Fiscal Year: 2003
    ....
  19. Mechanisms of Fever-Enhanced Acute Lung Injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE. Exposure to elevated body temperatures as occurs during fever or heat stroke changes the blood vessels and white blood cells to increase movement of white blood cells from the blood to the ..
  20. Heat Stroke & Hyperthermia: Applied Molecular Mechanisms
    Pope Moseley; Fiscal Year: 2006
    ....
  21. HEAT STROKE & HYPERTHERMIA--APPLIED MOLECULAR MECHANISMS
    Pope Moseley; Fiscal Year: 1999
    ..b>Heat stroke is the most catastrophic form of thermal injury and is characterized by cardiovascular collapse and multi-organ ..
  22. HSP 110 FAMILY AND ITS ROLES IN THERMOTOLERANCE
    John Subjeck; Fiscal Year: 2000
    ..that these differences parallel susceptibility of these regions to damage resulting from alcohol toxicity, heat stroke, and disease...
  23. HSP 110 FAMILY AND ITS ROLES IN THERMOTOLERANCE
    John Subjeck; Fiscal Year: 2002
    ..that these differences parallel susceptibility of these regions to damage resulting from alcohol toxicity, heat stroke, and disease...
  24. HSP 110 FAMILY AND ITS ROLES IN THERMOTOLERANCE
    John Subjeck; Fiscal Year: 1999
    ..that these differences parallel susceptibility of these regions to damage resulting from alcohol toxicity, heat stroke, and disease...
  25. HSP 110 FAMILY AND ITS ROLES IN THERMOTOLERANCE
    John Subjeck; Fiscal Year: 2001
    ..that these differences parallel susceptibility of these regions to damage resulting from alcohol toxicity, heat stroke, and disease...
  26. TEMPERATURE REGULATION AND ADAPTATION IN MACACA MULATTA
    REY ELIZONDO; Fiscal Year: 1980
    ..determine and quantitate the basic thermoregulatory malfunctions associated with disease states such as fever, heat stroke, and endocrine disorders in an attempt to provide better and more physiological management and treatment of ..
  27. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2009
    ..This basic science investigation will give new insights into fundamental skeletal muscle biology that will have applications to a variety of muscle disorders related to O2 transport limitation. ..
  28. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2003
    ..Biophysical measurements of the viscoelastic properties of muscle will be tested before and during stress. These studies should provide new information regarding the adaptive mechanisms muscle in stressful environments. ..
  29. MECHANISMS OF OXIDANT PRODUCTION IN RESPIRATORY FAILURE
    Thomas Clanton; Fiscal Year: 1999
    ..Furthermore, we hope to eventually understand the role of free radicals in muscle function and determine if there is a direct link between excess free radical production, muscle fatigue and contractile state. ..
  30. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2002
    ..Biophysical measurements of the viscoelastic properties of muscle will be tested before and during stress. These studies should provide new information regarding the adaptive mechanisms muscle in stressful environments. ..
  31. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2001
    ..Biophysical measurements of the viscoelastic properties of muscle will be tested before and during stress. These studies should provide new information regarding the adaptive mechanisms muscle in stressful environments. ..
  32. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2006
    ..This basic science investigation will give new insights into fundamental skeletal muscle biology that will have applications to a variety of muscle disorders related to O2 transport limitation. [unreadable] [unreadable] [unreadable]..
  33. LEAD-GENE INTERACTIONS AND CONGNITION
    Marc Weisskopf; Fiscal Year: 2006
    ..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
  34. Redox Signalling by Nitric Oxide in Skeletal Muscle
    JONATHAN STAMLER; Fiscal Year: 2008
    ..pathophysiology of a range of disease states including diaphragmatic dysfunction, malignant hypothermia, and heat stroke, in which the RyR plays a central role, as well as muscular dystrophies in which NO production is dysregulated...
  35. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2007
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..
  36. NEW BIOMARKERS OF NEUROTOXICITY
    Marc Weisskopf; Fiscal Year: 2007
    ..abstract_text> ..
  37. Population-Based Study of Environmental Risk Factors for ALS
    Marc G Weisskopf; Fiscal Year: 2010
    ..In, particular, we will focus on lead and formaldehyde exposure, trauma, and use of statin and hormone replacement therapy medications. Furthermore, we will assess whether these factors affect the survival of patients with ALS. ..
  38. Red Blood Cell S-nitrosothiols and Oxygenation
    JONATHAN STAMLER; Fiscal Year: 2009
    ....
  39. Regulation of Cardiac Adrenergic Function by S-nitrosylation
    JONATHAN STAMLER; Fiscal Year: 2009
    ....
  40. THE CELLULAR STRESS RESPONSE IN VIRAL ENCEPHALITIS
    Michael Oglesbee; Fiscal Year: 2008
    ..The experimental system uses measles virus, but the work has potential broad relevance to other viruses that infect brain. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Redox Signalling by Nitric Oxide in Skeletal Muscle
    JONATHAN STAMLER; Fiscal Year: 2009
    ..pathophysiology of a range of disease states including diaphragmatic dysfunction, malignant hypothermia, and heat stroke, in which the RyR plays a central role, as well as muscular dystrophies in which NO production is dysregulated...
  42. MOLECULAR MECHANISMS OF NITROSATIVE STRESS RESISTANCE
    JONATHAN STAMLER; Fiscal Year: 2000
    ..The reduced, oxidized, mixed disulfide and nitrosylated forms of purified OxyR are analyzed and their functional behaviors compared. ..
  43. REDOX SIGNALING BY NITRIC OXIDE IN SKELETAL MUSCLE
    JONATHAN STAMLER; Fiscal Year: 2001
    ..into the regulation of Ca2+ homeostasis in muscle and may allow a better understanding of disease states such as diaphragmatic dysfunction, malignant hypothermia and heat stroke in which the ryanodine receptor plays a central role.
  44. MOLECULAR MECHANISMS OF NITROSATIVE STRESS RESISTANCE
    JONATHAN STAMLER; Fiscal Year: 2001
    ..The reduced, oxidized, mixed disulfide and nitrosylated forms of purified OxyR are analyzed and their functional behaviors compared. ..
  45. THE CELLULAR STRESS RESPONSE IN VIRAL ENCEPHALITIS
    Michael Oglesbee; Fiscal Year: 2000
    ..abstract_text> ..
  46. REDOX SIGNALING BY NITRIC OXIDE IN SKELETAL MUSCLE
    JONATHAN STAMLER; Fiscal Year: 2002
    ..into the regulation of Ca2+ homeostasis in muscle and may allow a better understanding of disease states such as diaphragmatic dysfunction, malignant hypothermia and heat stroke in which the ryanodine receptor plays a central role.
  47. THE CELLULAR STRESS RESPONSE IN VIRAL ENCEPHALITIS
    Michael Oglesbee; Fiscal Year: 2002
    ..abstract_text> ..
  48. THE CELLULAR STRESS RESPONSE IN VIRAL ENCEPHALITIS
    Michael Oglesbee; Fiscal Year: 2003
    ..abstract_text> ..
  49. MOLECULAR MECHANISMS OF NITROSATIVE STRESS RESISTANCE
    JONATHAN STAMLER; Fiscal Year: 1999
    ..The reduced, oxidized, mixed disulfide and nitrosylated forms of purified OxyR are analyzed and their functional behaviors compared. ..
  50. REDOX SIGNALING BY NITRIC OXIDE IN SKELETAL MUSCLE
    JONATHAN STAMLER; Fiscal Year: 2005
    ..into the regulation of Ca2+ homeostasis in muscle and may allow a better understanding of disease states such as diaphragmatic dysfunction, malignant hypothermia and heat stroke in which the ryanodine receptor plays a central role.
  51. REDOX SIGNALING BY NITRIC OXIDE IN SKELETAL MUSCLE
    JONATHAN STAMLER; Fiscal Year: 2004
    ..into the regulation of Ca2+ homeostasis in muscle and may allow a better understanding of disease states such as diaphragmatic dysfunction, malignant hypothermia and heat stroke in which the ryanodine receptor plays a central role.
  52. REDOX SIGNALING BY NITRIC OXIDE IN SKELETAL MUSCLE
    JONATHAN STAMLER; Fiscal Year: 2003
    ..into the regulation of Ca2+ homeostasis in muscle and may allow a better understanding of disease states such as diaphragmatic dysfunction, malignant hypothermia and heat stroke in which the ryanodine receptor plays a central role.
  53. LEAD-GENE INTERACTIONS AND CONGNITION
    Marc Weisskopf; Fiscal Year: 2007
    ..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
  54. MOLECULAR MECHANISMS OF NITROSATIVE STRESS RESISTANCE
    JONATHAN STAMLER; Fiscal Year: 2002
    ..The reduced, oxidized, mixed disulfide and nitrosylated forms of purified OxyR are analyzed and their functional behaviors compared. ..
  55. NEW BIOMARKERS OF NEUROTOXICITY
    Marc Weisskopf; Fiscal Year: 2008
    ..abstract_text> ..
  56. NO HEMOGLOBIN INTERACTION IN THE PULMONARY VASCULATURE
    JONATHAN STAMLER; Fiscal Year: 2001
    ..abstract_text> ..
  57. The Pathogenesis and Genetics of Environmental Asthma
    JONATHAN STAMLER; Fiscal Year: 2007
    ..In aggregate, the coupled scientific findings in this program will substantially enhance our understanding of the pathogenesis and genetics of asthma. ..
  58. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2007
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..