substance withdrawal syndrome

Summary

Summary: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Top Publications

  1. ncbi Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Biol Psychiatry 58:392-400. 2005
  2. ncbi Effectiveness of current treatment approaches for benzodiazepine discontinuation: a meta-analysis
    Jannette M Parr
    School of Medicine, University of Queensland, Herston, Queensland, Australia
    Addiction 104:13-24. 2009
  3. ncbi Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
  4. ncbi Pre-cessation nicotine replacement therapy: pragmatic randomized trial
    Chris Bullen
    Clinical Trials Research Unit, School of Population Health, The University of Auckland, Auckland, New Zealand
    Addiction 105:1474-83. 2010
  5. ncbi Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study
    Dharma McBride
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuropsychopharmacology 31:2728-38. 2006
  6. ncbi Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
  7. ncbi Pharmacological approaches to the management of alcohol addiction
    G Addolorato
    Istituto di Medicina Interna, , Roma
    Eur Rev Med Pharmacol Sci 6:89-97. 2002
  8. ncbi Withdrawal from long-term benzodiazepine use: randomised trial in family practice
    Catalina Vicens
    Centre de Salut Son Serra la Vileta, Family and Community Medicine Teaching Unit Palma de Mallorca, Mallorca, Spain
    Br J Gen Pract 56:958-63. 2006
  9. ncbi Rapid suppression of alcohol withdrawal syndrome by baclofen
    Giovanni Addolorato
    Institute of Internal Medicine, , Rome, Italy
    Am J Med 112:226-9. 2002
  10. ncbi Effect of alcohol detoxification on serum S-100B levels of alcohol-dependent individuals
    Ioannis Liappas
    Department of Psychiatry, Eginition Hospital, University of Athens Medical School, Athens, Greece
    In Vivo 20:675-80. 2006

Research Grants

  1. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2004
  2. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
  3. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
  5. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
  6. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2003
  7. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2003
  8. Integrative Neuroscience Initiative on Alcoholism
    George Koob; Fiscal Year: 2007
  9. Neurpsychopharmacology-Multidisciplinary Training
    George Koob; Fiscal Year: 2007
  10. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2007

Detail Information

Publications217 found, 100 shown here

  1. ncbi Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Biol Psychiatry 58:392-400. 2005
    ..In rats, repeated episodes of alcohol consumption and withdrawal (RWD) impair fear conditioning to discrete cues...
  2. ncbi Effectiveness of current treatment approaches for benzodiazepine discontinuation: a meta-analysis
    Jannette M Parr
    School of Medicine, University of Queensland, Herston, Queensland, Australia
    Addiction 104:13-24. 2009
    ..To assess the effectiveness of current treatment approaches to assist benzodiazepine discontinuation...
  3. ncbi Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
    ..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence...
  4. ncbi Pre-cessation nicotine replacement therapy: pragmatic randomized trial
    Chris Bullen
    Clinical Trials Research Unit, School of Population Health, The University of Auckland, Auckland, New Zealand
    Addiction 105:1474-83. 2010
    ..To determine the effectiveness of 2 weeks' pre-cessation nicotine patches and/or gum on smoking abstinence at 6 months...
  5. ncbi Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study
    Dharma McBride
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuropsychopharmacology 31:2728-38. 2006
    ..Our findings confirm the importance of expectancy in the neural response to drug cues, and lend support to the theory that these cues act on brain areas involved in arousal and attention...
  6. ncbi Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
    ..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues...
  7. ncbi Pharmacological approaches to the management of alcohol addiction
    G Addolorato
    Istituto di Medicina Interna, , Roma
    Eur Rev Med Pharmacol Sci 6:89-97. 2002
    ..However, pharmacotherapy should not be considered as the only form of treatment but as an integrated part of a multimodal approach including psychological and social support...
  8. ncbi Withdrawal from long-term benzodiazepine use: randomised trial in family practice
    Catalina Vicens
    Centre de Salut Son Serra la Vileta, Family and Community Medicine Teaching Unit Palma de Mallorca, Mallorca, Spain
    Br J Gen Pract 56:958-63. 2006
    ..Withdrawing patients from these drugs is often difficult. Tapering off benzodiazepines has been shown to be a good strategy for discontinuing their long-term use...
  9. ncbi Rapid suppression of alcohol withdrawal syndrome by baclofen
    Giovanni Addolorato
    Institute of Internal Medicine, , Rome, Italy
    Am J Med 112:226-9. 2002
  10. ncbi Effect of alcohol detoxification on serum S-100B levels of alcohol-dependent individuals
    Ioannis Liappas
    Department of Psychiatry, Eginition Hospital, University of Athens Medical School, Athens, Greece
    In Vivo 20:675-80. 2006
    ..The aim of this study was to evaluate the serum levels of S100B in alcohol-dependent individuals and to further investigate the effect of alcohol detoxification on the levels of S100B...
  11. ncbi Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency
    C V McMillan
    Royal Holloway, University of London, Egham, Surrey, UK
    Clin Endocrinol (Oxf) 59:467-75. 2003
    ..The objective of this study was to investigate the psychological effects of discontinuation of GH replacement from adults with severe GH deficiency (GHD)...
  12. ncbi A specific limbic circuit underlies opiate withdrawal memories
    Francois Frenois
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 5541 Interactions Neuronales et Comportements, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    J Neurosci 25:1366-74. 2005
    ..This first study on the neural substrates of withdrawal memories strongly supports an incentive-motivational view of withdrawal in opiate addiction that could be crucial in compulsive drug seeking and relapse...
  13. ncbi Alcohol dependence: analysis of factors associated with retention of patients in outpatient treatment
    Márcia Fonsi Elbreder
    Alcohol and Drugs Research Unit Uniad, Rua Botucatu 394 Vila Clementino CEP 04023 061, Sao Paulo SP, Brazil
    Alcohol Alcohol 46:74-6. 2011
    ..To identify factors associated with retention in treatment of alcohol-dependent individuals and to compare treatment retention between men and women...
  14. ncbi Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses
    Maurizio A Leone
    SCDU Neurologia, , C Mazzini 18, 28100 Novara, Italy
    Cochrane Database Syst Rev 2:CD006266. 2010
    ..Side effects of GHB are not statistically different from those with BZD, NTX or Disulfiram. However, concern has been raised regarding the risk of developing addiction, misuse or abuse, especially in polydrug abusers...
  15. ncbi Medications acting on the GABA system in the treatment of alcoholic patients
    Fabio Caputo
    Department of Internal Medicine, SS Annunziata Hospital, Via Vicini 2, 44042, Cento Ferrara, Italy
    Curr Pharm Des 16:2118-25. 2010
    ..Thus, given the importance of GABA-ergic mechanisms in the development and maintenance of alcohol dependence, and the very interesting results currently achieved, more research on GABAergic agents is warranted...
  16. ncbi A randomized clinical trial of St. John's wort for smoking cessation
    Amit Sood
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Altern Complement Med 16:761-7. 2010
    ..St. John's wort (SJW) is a widely used herbal supplement. The predominant mechanism(s) accounting for the activity of SJW in vivo are, however, unclear. The purpose of this study was to investigate the efficacy of SJW for smoking cessation...
  17. ncbi Withdrawal from alcohol using monitored alcohol consumption: a case report
    Neil R Wright
    Nottingham Alcohol and Drug Team, The Wells Road Centre, The Wells Road, Nottingham NG3 3AA and Sneinton Hermitage, 35-37 Sneinton Hermitage, Sneinton, Nottingham NG2 4BT, UK
    Alcohol Alcohol 37:344-6. 2002
    ..CONCLUSIONS: Withdrawal from alcohol through monitored alcohol consumption is a potentially effective and rapid procedure, but the limits of its appropriate use have not been established...
  18. ncbi Smoking cessation and smoking patterns in the general population: a 1-year follow-up
    R West
    St George s Hospital Medical School, Cranmer Terrace, London, UK
    Addiction 96:891-902. 2001
    ....
  19. ncbi General anaesthesia does not improve outcome in opioid antagonist detoxification treatment: a randomized controlled trial
    Cor A J De Jong
    Novadic Kentron Network for Addiction Treatment Services, Nijmegen Institute for Scientist Practitioners in Addiction, Radboud University Nijmegen, Nijmegen, Netherlands
    Addiction 100:206-15. 2005
    ..This study is conducted to determine whether rapid detoxification under general anaesthesia results in higher levels of opioid abstinence than rapid detoxification without anaesthesia...
  20. ncbi Incubation of cocaine craving after withdrawal: a review of preclinical data
    Lin Lu
    Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:214-26. 2004
    ..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas...
  21. ncbi [Restlessness in intensive care unit: think to the nicotinic withdrawal syndrome]
    D Tran-Van
    Departement d Anesthésie Réanimation Urgences, HIA Robert Picque, BP 28, 33998 Bordeaux Armées, France
    Ann Fr Anesth Reanim 23:604-6. 2004
    ..This observation suggests that the nicotine withdrawal syndrome is an unrecognized cause of restlessness and that the transdermal nicotine patch should be a diagnosis means which is safe, cheap and easy to use...
  22. ncbi Bringing buprenorphine-naloxone detoxification to community treatment providers: the NIDA Clinical Trials Network field experience
    Leslie Amass
    Friends Research Institute, Inc, 11075 Santa Monica Boulevard, Suite 200, Los Angeles, CA 90025, USA
    Am J Addict 13:S42-66. 2004
    ....
  23. ncbi Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans
    Andrew G Davies
    Ernest Gallo Clinic and Research Center, Department of Neurology, Programs in Neuroscience and Biomedical Science, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
    Neuron 42:731-43. 2004
    ..Moreover, these data indicate that genetic variation in the level of NPR-1 function determines much of the phenotypic variation in adaptive behavioral responses to ethanol that are observed in natural populations...
  24. ncbi Evaluation of the mood and physical symptoms scale (MPSS) to assess cigarette withdrawal
    Robert West
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK
    Psychopharmacology (Berl) 177:195-9. 2004
    ..The mood and physical symptoms scale (MPSS) was developed in the early 1980s to assess cigarette withdrawal symptoms, and variants of it have been used for 20 years. To date, no paper has been published on the properties of the scale...
  25. ncbi Gamma-hydroxybutyric acid in the treatment of alcohol withdrawal syndrome in patients admitted to hospital
    C Korninger
    Lorenz Böhler Trauma Unit, Donaueschingenstrasse 13, A 1200 Wien
    Acta Med Austriaca 30:83-6. 2003
    ..Adverse events were rare and mild. It is concluded that gamma-hydroxybutyric acid is an attractive alternative to tranquilizers in the management of the alcohol withdrawal syndrome in hospital...
  26. ncbi The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients
    Elinore F McCance-Katz
    Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Infect Dis 37:476-82. 2003
    ..Lopinavir is a potent inducer of methadone metabolism, and treatment with L/R requires clinical monitoring and increased methadone doses in some patients, whereas ritonavir has no significant effect on methadone metabolism...
  27. ncbi Gamma hydroxybutyrric acid (GHB) withdrawal does not occur at therapeutic dosage
    G Addolorato
    Drug Alcohol Depend 77:209. 2005
  28. ncbi Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    JAMA 294:903-13. 2005
    ..Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence...
  29. ncbi Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:231-42. 2006
    ..Study findings require confirmation in additional larger samples before they are applied in practice...
  30. ncbi Nicotine withdrawal symptoms following a quit attempt: an ecological momentary assessment study among adolescents
    Rinka M P Van Zundert
    Behavioural Science Institute, Radboud University, PO Box 9104, Nijmegen 6500 HE, The Netherlands
    Nicotine Tob Res 11:722-9. 2009
    ..The present study describes growth curves of withdrawal symptoms among 138 daily smoking adolescents before, during, and after a quit attempt...
  31. ncbi Nicotine withdrawal and agitation in ventilated critically ill patients
    Olivier Lucidarme
    Service de Reanimation Polyvalente, CH mémorial France Etats Unis de Saint Lô, Saint Lô, France
    Crit Care 14:R58. 2010
    ....
  32. ncbi Dialectical behavior therapy for substance abusers
    Linda A Dimeff
    Behavioral Tech Research, Inc, Seattle, Washington 98105, USA
    Addict Sci Clin Pract 4:39-47. 2008
    ..The treatment also may be helpful for patients who have other severe disorders co-occurring with SUDs or who have not responded to other evidence-based SUD therapies...
  33. ncbi The search for medications to treat stimulant dependence
    Kyle M Kampman
    University of Pennsylvania School of Medicine and Treatment Research Center, Philadelphia, Pennsylvania 19104, USA
    Addict Sci Clin Pract 4:28-35. 2008
    ..Treatment approaches that combine efficacious medications and empirically proven behavioral interventions, such as voucher-based reinforcement therapy, will almost certainly produce the best results...
  34. ncbi Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt
    Robert West
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Brook House, London, UK
    Psychopharmacology (Berl) 197:371-7. 2008
    ....
  35. ncbi PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Eur J Pharmacol 579:160-6. 2008
    ..Our findings suggest that chronic opioid use induces long-lasting striatum dopamine neuron impairment, and prolonged withdrawal from opioids can benefit the recovery of impaired dopamine neurons in the brain...
  36. ncbi Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..In addition, nicotine withdrawal selectively affects acquisition but not recall or expression of the learned response...
  37. ncbi In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone
    J McCambridge
    National Addiction Centre, Institute of Psychiatry, King s College London, 4 Windsor Walk, Camberwell, London SE5 8AF, United Kingdom
    Drug Alcohol Depend 88:91-5. 2007
    ..A cohort study design was used with double-blind random allocation to lofexidine+naloxone versus lofexidine+placebo. Patients who did not consent to, or who were excluded from randomisation received methadone...
  38. ncbi Physiologic mechanisms underlying the antidepressant discontinuation syndrome
    Pierre Blier
    Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Psychiatry 67:8-13. 2006
    ..It also attempts to explain their implications in the therapeutic actions of antidepressants in patients with affective and anxiety disorders...
  39. ncbi The place of detoxification in treatment of opioid dependence
    Linda R Gowing
    Drug and Alcohol Services South Australia, Australia
    Curr Opin Psychiatry 19:266-70. 2006
    ..This review summarizes current research on the management of opioid withdrawal and considers the selection of the approach in different situations...
  40. ncbi A comparison of the psychometric properties of three cigarette withdrawal scales
    Jean Francois Etter
    Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Addiction 101:362-72. 2006
    ..To compare the psychometric properties of three cigarette withdrawal scales...
  41. ncbi Opioids and abnormal pain perception: New evidence from a study of chronic opioid addicts and healthy subjects
    Dorit Pud
    Faculty of Social Welfare and Health Studies, University of Haifa, Israel; Haifa Pain Research Group, Israel
    Drug Alcohol Depend 82:218-23. 2006
    ..In addition, it appears that detoxification from opioids does not reset pain perception for at least 1 month...
  42. ncbi Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:1203-11. 2006
    ....
  43. ncbi Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders
    Andrea H Weinberger
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 108:7-12. 2010
    ..The current study examined tobacco withdrawal symptoms and withdrawal-related discomfort and relapse in smokers with and without current mood disorders, anxiety disorders, alcohol use disorders (AUD), and substance use disorders (SUD)...
  44. ncbi Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration
    M Scott Bowers
    Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB Suite 403, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 17:1273-8. 2003
    ..Furthermore, the increase in GFAP may arise from regionally distinct mechanisms, with the NAcore relying more on cell proliferation while the PFC relies on a larger reactive astrocyte population...
  45. ncbi Opioid effects and opioid withdrawal during a 24 h dosing interval in patients maintained on buprenorphine
    Olga V Lopatko
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, SA, Australia
    Drug Alcohol Depend 69:317-22. 2003
    ....
  46. ncbi Cognitive functioning of long-term heavy cannabis users seeking treatment
    Nadia Solowij
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    JAMA 287:1123-31. 2002
    ..Cognitive impairments are associated with long-term cannabis use, but the parameters of use that contribute to impairments and the nature and endurance of cognitive dysfunction remain uncertain...
  47. ncbi GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng-Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
    ..The increase may be mediated in part by functional desensitization of GABA(B) receptors, likely the result of diminished Ser phosphorylation of the GABA(B2) receptor...
  48. ncbi Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat
    John F Cryan
    Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:347-58. 2003
    ..Third, bupropion reverses the negative affective aspects of nicotine withdrawal. Such actions are likely to act in concert to mediate the unique anti-smoking properties of bupropion...
  49. ncbi Varenicline in prevention of relapse to smoking: effect of quit pattern on response to extended treatment
    Peter Hajek
    Wolfson Institute of Preventive Medicine, UK Centre for Tobacco Control Studies, Barts and The London, Queen Mary University of London, London E1 2AD, UK
    Addiction 104:1597-602. 2009
    ..In this secondary analysis, trial data were examined to see whether smokers who manage to achieve abstinence only later in the original course of treatment are more likely to benefit from having the course extended...
  50. ncbi GABA systems, benzodiazepines, and substance dependence
    Robert J Malcolm
    Medical University of South Carolina, Center for Drug and Alcohol Programs, Charleston 29425, USA
    J Clin Psychiatry 64:36-40. 2003
    ..The GABA(A) and GABA(B) pump reuptake inhibitor tiagabine has potential for managing alcohol and sedative-hypnotic withdrawal and also possibly a role in relapse prevention...
  51. ncbi High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:202-12. 2002
    ..The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin...
  52. ncbi Association of cocaine withdrawal symptoms with more severe dependence and enhanced subjective response to cocaine
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, School of Medicine, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Drug Alcohol Depend 69:273-82. 2003
    ..4 mg/kg of smoked cocaine. These results suggest that history of cocaine withdrawal symptoms may be associated with enhanced cocaine responses and greater severity of cocaine dependence...
  53. ncbi Ultra-rapid opiate detoxification using deep sedation and prior oral buprenorphine preparation: long-term results
    C Bochud Tornay
    Department of Adult Psychiatry, Cery Hospital, 1008, Prilly-Lausanne, Switzerland
    Drug Alcohol Depend 69:283-8. 2003
    ..In the long term, a few patients were still free of opiates, while the majority opted for a methadone maintenance program, showing that URD can serve as one possible step in a long-term treatment program...
  54. ncbi Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy
    P J H M Stouthart
    Department of Pediatrics, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, Netherlands
    Psychoneuroendocrinology 28:612-26. 2003
    ..It is concluded that one year discontinuation of GH treatment leads to a decrease in QoL within 6 months which effect is counteracted within 6 months after restart of GH treatment...
  55. ncbi Intrathecal baclofen withdrawal mimicking sepsis
    Louise W Kao
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Emerg Med 24:423-7. 2003
    ..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
  56. ncbi Delirium from nicotine withdrawal in neuro-ICU patients
    S A Mayer
    Division of Critical Care Neurology, Department of Neurology, Columbia Presbyterian Medical Center and College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 57:551-3. 2001
    ..These preliminary observations suggest that nicotine withdrawal may be an under-recognized cause of delirium in patients with acute brain injury...
  57. ncbi Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement
    D Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Behav Pharmacol 13:389-96. 2002
    ..Thus, the type of self-administration history and the length of deprivation experienced contribute to changes in the reinforcing efficacy of cocaine as measured by a PR schedule...
  58. ncbi Complications of ultrarapid opioid detoxification with subcutaneous naltrexone pellets
    Richard J Hamilton
    MCP Hahnemann University, Philadelphia, PA 19129, USA
    Acad Emerg Med 9:63-8. 2002
    ..CONCLUSIONS: The risks of this procedure are great and further studies should assess its safety and the novel use of naltrexone...
  59. ncbi Self-reported abstinence effects in the first month after smoking cessation
    M M Ward
    Department of Health Management and Policy, University of Iowa, Iowa City 52242 1008, USA
    Addict Behav 26:311-27. 2001
    ....
  60. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
    ..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
  61. ncbi Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial
    J P Reoux
    Veterans Affairs Puget Sound Health Care System and Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington 98108, USA
    Alcohol Clin Exp Res 25:1324-9. 2001
    ..This study reports on a randomized, double-blind, placebo-controlled trial of divalproex sodium in acute alcohol withdrawal...
  62. ncbi A randomized controlled trial of buprenorphine in the management of short-term ambulatory heroin withdrawal
    Nicholas Lintzeris
    Turning Point Alcohol and Drug Centre, Fitzroy, Victoria, Australia
    Addiction 97:1395-404. 2002
    ..To determine whether buprenorphine is more effective than clonidine and other symptomatic medications in managing ambulatory heroin withdrawal...
  63. ncbi Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine
    Geng Chang Yeh
    Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 453:197-202. 2002
    ..Thus, the results from the present study support that dextromethorphan is of potential in treating or preventing neonatal morphine withdrawal syndrome...
  64. ncbi Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome
    Stephanie Caillé
    Lab de Neuropsychobiologie des Désadaptations, CNRS UMR 5541, BP31, Universite de Bordeaux II, Bordeaux, France
    Pharmacol Biochem Behav 72:979-86. 2002
    ..These results demonstrate that 5-HT systems are not directly responsible for the development of the somatic opiate withdrawal syndrome in morphine-dependent rats...
  65. ncbi Effects of recurrent withdrawal on spinal GABA release during chronic morphine infusion in the rat
    Stuart A Dunbar
    Department of Anesthesiology, Baystate Medical Center, Tufts University, 3400 Main Street, Springfield, MA 01199, USA
    Eur J Pharmacol 535:152-6. 2006
    ..These observed changes in GABA release offer direct evidence that GABA may contribute to the altered nociceptive response mediated by opioids...
  66. ncbi Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis
    S Sinchaisuk
    Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216-4505, USA
    Pharmacol Biochem Behav 74:241-52. 2002
    ....
  67. ncbi Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal
    G P McNally
    Mental Health Research Institute, The University of Michigan, Ann Arbor, MI, USA
    Neuroscience 112:605-17. 2002
    ....
  68. ncbi Influence of ATP-dependent K+ channels on nicotine-induced inhibition of withdrawal in morphine-dependent mice
    Mohammad Reza Zarrindast
    Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 552:90-8. 2006
    ..According to these results the interaction of nicotine with the K(ATP) channel opener and blocker in morphine physical withdrawal signs could be explained by direct and indirect effects of nicotine on membrane potassium currents...
  69. ncbi Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence
    Tuan Trang
    Department of Pharmacology and Toxicology and Anesthesiology, Queen s University Kingston, Ont, Canada K7L 3N6
    Pain 126:256-71. 2006
    ..Altogether, this study suggests that endocannabinoid activity, expressed via CB1-receptors, contributes to the induction of opioid physical dependence through spinal modulation of CGRP...
  70. ncbi Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6450-7. 2006
    ..Regardless, these findings suggest for the first time that D1 agonists might be useful for the treatment of withdrawal symptoms that contribute to the maintenance of opiate addiction in humans...
  71. ncbi Withdrawal from dependence upon butorphanol uniquely increases kappa(1)-opioid receptor binding in the rat brain
    Lir-Wan Fan
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Brain Res Bull 58:149-60. 2002
    ..The brain kappa(1)-opioid receptor appears to be more directly involved in the development of physical dependence upon, and the expression of withdrawal from, butorphanol, as opposed to the prototypical opioid analgesic, morphine...
  72. ncbi Noradrenaline release in rat locus coeruleus is regulated by both opioid and alpha(2) -adrenoceptors
    Tohru Nakai
    Department of Clinical Pharmacology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-02, Japan
    Pharmacol Res 45:407-12. 2002
    ..These results directly suggest that NA increased within the LC after the naloxone challenge in morphine-dependent animals pretreated with yohimbine may be, at least in part, regulated by alpha(2) -adrenoceptors in the LC...
  73. ncbi Rapid neuroadaptation in the nucleus accumbens and bed nucleus of the stria terminalis mediates suppression of operant responding during withdrawal from acute opioid dependence
    S H Criner
    Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neuroscience 144:1436-46. 2007
    ....
  74. ncbi Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal
    Pilar Almela
    Equip of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
    Naunyn Schmiedebergs Arch Pharmacol 374:293-303. 2007
    ....
  75. ncbi Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal
    P Almela
    Department of Pharmacology, University School of Medicine, Murcia, Spain
    Br J Pharmacol 151:787-97. 2007
    ..Here, we have looked for activation of ERK during morphine withdrawal and if this activation induced gene expression...
  76. ncbi Alterations in cerebral diazepam binding inhibitor expression in drug dependence: a possible biochemical alteration common to drug dependence
    S Ohkuma
    Department of Pharmacology, Kawasaki Medical School, Kurashiki, Japan
    Life Sci 68:1215-22. 2001
    ..Finding and elucidation of mechanisms for common biochemical alterations among drug dependence may provide a clue to clarify mechanisms for formation of drug dependence and/or emergence of withdrawal syndrome...
  77. ncbi Substance P endopeptidase-like activity is altered in various regions of the rat central nervous system during morphine tolerance and withdrawal
    Q Zhou
    Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, S-751 24, Uppsala, Sweden
    Neuropharmacology 41:246-53. 2001
    ..Our result suggests that the elevated SPE-like activity is responsible for enhanced release of SP(1-7) in rats during morphine withdrawal, affirming a modulatory or regulative role of this enzyme in this state of opioid dependence...
  78. ncbi Local opiate withdrawal in locus coeruleus neurons in vitro
    A Ivanov
    Department of Psychiatry, University of Pennsylvania, Veterans Affairs Medical Center (151, Philadelphia, Pennsylvania 19104, USA
    J Neurophysiol 85:2388-97. 2001
    ..These results suggest that upregulation of cAMP-dependent protein kinase A during chronic morphine treatment is involved in the withdrawal-induced hyperactivity of LC neurons...
  79. ncbi Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice
    A M Salmon
    CNRS URA 2182, Neurobiologie moleculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Neurosci 4:357-8. 2001
    ....
  80. ncbi Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine
    Linda A Parke
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 26:293-7. 2002
    ..In Experiment 1, ibogaine-treated rats displayed a weaker aversion to the withdrawal-paired chamber, and in Experiment 2, ibogaine-treated rats displayed fewer somatic withdrawal reactions than did saline treated rats...
  81. ncbi Plasma malondialdehyde levels and opiate withdrawal signs observed in rats treated with morphine plus naloxone: effects of alpha-lipoic acid administration
    Arnaldo Pinelli
    Department of Pharmacology, University of Milan, Milan, Italy
    Fundam Clin Pharmacol 22:439-45. 2008
    ..The effects of LA were attributed to its capacity to scavenge peroxides and interfere with the biogenesis of the arachidonic acid metabolites involved in the expression of abstinence symptoms...
  82. ncbi Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats
    Antoni Sastre-Coll
    Laboratory of Neuropharmacology, Associate Unit of the Institute Cajal/CSIC, Department of Biology, University of the Balearic Islands, Cra. Valldemossa Km 7.5, 07071 Palma de Mallorca, Spain
    Naunyn Schmiedebergs Arch Pharmacol 365:210-9. 2002
    ..In summary, we conclude that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain...
  83. ncbi Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys
    Rui Bin Su
    Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
    Eur J Pharmacol 587:155-62. 2008
    ..g.) inhibited the naturally abstinent syndrome during the 7-d abstinent period. All these results suggested that intragastric administration of agmatine inhibits morphine-induced physiological dependence in animal models...
  84. ncbi Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone
    EBONY M GLOVER
    Department of Psychology, Emory University, Atlanta, GA, USA
    Psychopharmacology (Berl) 198:167-80. 2008
    ..Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not...
  85. ncbi L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone
    Saeed Esmaeili-Mahani
    Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran
    Horm Behav 53:351-7. 2008
    ..Thus, we have shown the involvement of the HPA axis in the effect of nifedipine on the development of morphine dependency and additionally demonstrated an in vivo interaction between the L-type Ca2+ channels and corticosterone...
  86. ncbi The role of spinal neuropeptides and prostaglandins in opioid physical dependence
    Tuan Trang
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada, K7L 3N6
    Br J Pharmacol 136:37-48. 2002
    ....
  87. ncbi Effects of the NMDA receptor antagonist memantine on the expression and development of acute opiate dependence as assessed by withdrawal-potentiated startle and hyperalgesia
    Andrew C Harris
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 196:649-60. 2008
    ..While the N-methyl-D: -aspartate (NMDA) glutamate receptor has been strongly implicated in chronic opiate dependence, relatively few studies have examined the effects of NMDA receptor antagonists on withdrawal from acute opiate exposure...
  88. ncbi Repeated administration of nicotine attenuates the development of morphine tolerance and dependence in mice
    Abbas Haghparast
    Neuroscience Research Center, Shaheed Beheshti Medical University, P O Box 19615 1178, Tehran, Iran
    Pharmacol Biochem Behav 88:385-92. 2008
    ..The data suggests that the inhibitory effect of nicotine on the morphine tolerance and dependence is mediated by central nicotinic receptors and there is a cross-dependence between nicotine and morphine...
  89. ncbi Involvement of glutamate receptors within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats
    Takeshi Watanabe
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Jpn J Pharmacol 88:399-406. 2002
    ..These results suggest that the activation of AMPA /kainate and NMDA receptors within the CeA play a crucial role in the negative affective component of morphine abstinence...
  90. ncbi Morphine withdrawal increases expression of GABA(A) receptor epsilon subunit mRNA in locus coeruleus neurons
    A T Heikkilä
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    Neuroreport 12:2981-5. 2001
    ..Similar changes were detected in tyrosine hydroxylase mRNA expression. The results suggest increased formation of unique GABA(A) receptor subtype(s) in the locus coeruleus neurons during increased neuronal activity...
  91. ncbi Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system
    Stephanie Le Guen
    Laboratoire de Physiopharmacologie du Système Nerveux, Institut National de la Santé et de la Recherche Médicale INSERM and Ecole Pratique des Hautes Etudes EPHE, Paris, France
    Eur J Neurosci 17:2425-37. 2003
    ..Therefore, delta and kappa opioid receptors may also contribute slightly to opioid dependence...
  92. ncbi Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 110:281-9. 2004
    ....
  93. ncbi Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal
    Marc R Azar
    Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, 3350 La Jolla Village Drive, MC 125, San Diego, CA 92161-5085, USA
    Psychopharmacology (Berl) 170:42-50. 2003
    ..CONCLUSIONS: CPA is a reliable and sensitive index of the aversive motivational state accompanying withdrawal from acute opioid dependence...
  94. ncbi Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal
    Susanne Ammon
    Institute of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str. 44, D-39120, Magdeburg, Germany
    Brain Res Mol Brain Res 112:113-25. 2003
    ....
  95. ncbi Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
    Luis Stinus
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux II, Bordeaux, Cedex, France
    Neuropsychopharmacology 30:90-8. 2005
    ..In addition, these results suggest that CRF1 antagonists can block the aversive stimulus effects of opiate withdrawal and may be potential therapeutic targets for opiate dependence...
  96. ncbi Conditioning processes contribute to severity of naloxone-precipitated withdrawal from acute opioid dependence
    Gery Schulteis
    Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 5085, USA
    Psychopharmacology (Berl) 175:463-72. 2004
    ....
  97. ncbi Benefits of external qigong therapy on morphine-abstinent mice and rats
    Zhixian Mo
    Department of Traditional Chinese Medicine, The First Military Medical University, Guangzhou, China
    J Altern Complement Med 9:827-35. 2003
    ..Three different designs confirm that the impact of qigong therapy on morphine-abstinent mice and rats is reliable and substantial. Further research on the effectiveness and the mechanism of qigong therapy on addiction is warranted...
  98. ncbi Matricaria chamomilla extract inhibits both development of morphine dependence and expression of abstinence syndrome in rats
    Adel Gomaa
    Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt
    J Pharmacol Sci 92:50-5. 2003
    ..chamomilla extract with morphine. These results suggest that M. chamomilla extract inhibits the development of morphine dependence and expression of abstinence syndrome...
  99. ncbi The role of nitric oxide in morphine dependence and withdrawal excitation of rat oxytocin neurons
    Philip M Bull
    School of Biomedical and Clinical Laboratory Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Eur J Neurosci 18:2545-51. 2003
    ..Hence there is no evidence that changes in NO regulation underlie excitation of oxytocin neurons during opiate withdrawal in morphine dependence...
  100. ncbi Antinociceptive potentiation and attenuation of tolerance by intrathecal electric stimulation in rats
    Chung-Ren Lin
    Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
    Anesth Analg 96:1711-6, table of contents. 2003
    ..This may warrant further investigation in the context of long-term use of intrathecal opioids for controlling chronic pain...
  101. ncbi Changes in the brain kappa-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol
    L W Fan
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 121:1063-74. 2003
    ....

Research Grants138 found, 100 shown here

  1. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2004
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  2. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  3. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  5. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  6. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2003
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  7. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2003
    ....
  8. Integrative Neuroscience Initiative on Alcoholism
    George Koob; Fiscal Year: 2007
    ..The INIA program will be directed by an Administrative Core in close cooperation with the Executive Committee, Steering Committee, and with the continual advice of the Scientific Advisory Board. ..
  9. Neurpsychopharmacology-Multidisciplinary Training
    George Koob; Fiscal Year: 2007
    ..In summary, the training program discussed herein provides a dynamic environment for fellows to develop a strong foundation to pursue a career in the neuropsychopharmacology of alcoholism. ..
  10. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2007
    ..data to understand the neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment ..
  11. NEURONAL SUBSTRATES OF COCAINE REWARD
    George F Koob; Fiscal Year: 2010
    ....
  12. Central mechanisms of nicotine reinforcement and dependence
    George Koob; Fiscal Year: 2009
    ..abstract_text> ..
  13. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 1991
    ..These results should have important implications not only for our understanding of the neurobiology of ethanol intoxication but may lead to the development of viable pharmacological intervention in alcoholism...
  14. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1993
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  15. DOPAMINE PARTIAL AGONISTS AND COCAINE DEPENDENCE
    George Koob; Fiscal Year: 1999
    ..These studies will help elucidate the effectiveness of dopamine partial agonists with a wide range of intrinsic efficacies in modifying various phases of the natural history of psychostimulant dependence. ..
  16. Central mechanisms of nicotine reinforcement and dependence
    George F Koob; Fiscal Year: 2010
    ....
  17. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2007
    ....
  18. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George Koob; Fiscal Year: 2007
    ..Training and information dissemination to the San Diego community will be effected by the training opportunities of the Center including an NIAAA training grant and the Education Component. ..
  19. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2009
    ....
  20. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1993
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  21. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence H Sweet; Fiscal Year: 2011
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  22. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence Sweet; Fiscal Year: 2009
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  23. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk J Brower; Fiscal Year: 2010
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  24. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    KELLY COSGROVE; Fiscal Year: 2009
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
  25. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    Kelly P Cosgrove; Fiscal Year: 2010
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
  26. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2009
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  27. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2009
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  28. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2010
    ..These novel treatments may aid in improving smoking cessation rates. ..
  29. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2007
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  30. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2007
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  31. Health Communications and Risk Processing Among Smokers
    JENNIFER VIDRINE; Fiscal Year: 2006
    ..Findings have the potential to shed light on important mechanisms that may influence the construction of risk perceptions and on how perceptions of risk and smoking behavior may be reciprocally related. ..
  32. TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
    KELLY COSGROVE; Fiscal Year: 2002
    ..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
  33. Ecology Momentary Assessment of College Smoking
    THOMAS PIASECKI; Fiscal Year: 2003
    ..This project has the potential to address key questions about the early smoking career in a population at risk for the development of chronic tobacco dependence. ..
  34. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..