substance withdrawal syndrome

Summary

Summary: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Top Publications

  1. ncbi Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt
    Robert West
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Brook House, London, UK
    Psychopharmacology (Berl) 197:371-7. 2008
  2. pmc Chronic stress, drug use, and vulnerability to addiction
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06515, USA
    Ann N Y Acad Sci 1141:105-30. 2008
  3. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
  4. pmc Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010
  5. pmc CRF₂ mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats
    Javier Navarro-Zaragoza
    Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
    Br J Pharmacol 162:851-62. 2011
  6. pmc Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal
    Guofu Shen
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Toledo, OH 43614, USA
    Neuropsychopharmacology 35:1897-909. 2010
  7. pmc Instructed smoking expectancy modulates cue-elicited neural activity: a preliminary study
    Stephen J Wilson
    Department of Psychology, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 7:637-45. 2005
  8. ncbi Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence
    Harinder Aujla
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:1818-26. 2008
  9. doi Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence
    Xiao Li Zhang
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Psychiatry 168:610-6. 2011
  10. doi Risk assessment of moderate to severe alcohol withdrawal--predictors for seizures and delirium tremens in the course of withdrawal
    Florian Eyer
    Department of Toxicology, II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Alcohol Alcohol 46:427-33. 2011

Research Grants

  1. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2004
  2. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2004
  3. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
  4. Human Laboratory Studies for Stimulant Addiction
    Mehmet Sofuoglu; Fiscal Year: 2008
  5. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2008
  6. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2006
  7. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
  8. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
  9. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2008
  10. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2009

Detail Information

Publications274 found, 100 shown here

  1. ncbi Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt
    Robert West
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Brook House, London, UK
    Psychopharmacology (Berl) 197:371-7. 2008
    ....
  2. pmc Chronic stress, drug use, and vulnerability to addiction
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06515, USA
    Ann N Y Acad Sci 1141:105-30. 2008
    ....
  3. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
    ....
  4. pmc Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010
    ..g. depression, psychosis) persist beyond a month of abstinence...
  5. pmc CRF₂ mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats
    Javier Navarro-Zaragoza
    Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
    Br J Pharmacol 162:851-62. 2011
    ....
  6. pmc Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal
    Guofu Shen
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Toledo, OH 43614, USA
    Neuropsychopharmacology 35:1897-909. 2010
    ....
  7. pmc Instructed smoking expectancy modulates cue-elicited neural activity: a preliminary study
    Stephen J Wilson
    Department of Psychology, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 7:637-45. 2005
    ..These results highlight the importance of perceived drug use opportunity in the neurobiological response to drug cues...
  8. ncbi Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence
    Harinder Aujla
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:1818-26. 2008
    ....
  9. doi Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence
    Xiao Li Zhang
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Psychiatry 168:610-6. 2011
    ....
  10. doi Risk assessment of moderate to severe alcohol withdrawal--predictors for seizures and delirium tremens in the course of withdrawal
    Florian Eyer
    Department of Toxicology, II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Alcohol Alcohol 46:427-33. 2011
    ..To develop a prediction model for withdrawal seizures (WS) and delirium tremens (DT) during moderate to severe alcohol withdrawal syndrome (AWS) in a large cohort of inpatients treated for AWS (n = 827)...
  11. ncbi Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Biol Psychiatry 58:392-400. 2005
    ..In rats, repeated episodes of alcohol consumption and withdrawal (RWD) impair fear conditioning to discrete cues...
  12. pmc Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal
    Alice Dobi
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:1895-904. 2011
    ..In conclusion, a few repeated cocaine injections are enough to trigger adaptations at glutamatergic synapses in D(1)-expressing MSNs, which, although they take time to develop, do not require prolonged cocaine withdrawal...
  13. pmc Altered dendritic spine plasticity in cocaine-withdrawn rats
    Hao wei Shen
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 29:2876-84. 2009
    ..These data indicate that daily cocaine pretreatment dysregulates dendritic spine plasticity elicited by a subsequent cocaine injection...
  14. doi Modeling withdrawal syndrome in zebrafish
    Jonathan Cachat
    Department of Pharmacology and Neuroscience Program, Tulane University Medical School, New Orleans, LA 70112, USA
    Behav Brain Res 208:371-6. 2010
    ..Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome...
  15. ncbi The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
    ..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...
  16. ncbi Drug addiction
    Jordi Camí
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    N Engl J Med 349:975-86. 2003
  17. ncbi Medication-overuse headache: where are we now?
    Zaza Katsarava
    Department of Neurology, University of Essen, Essen, Denmark
    Curr Opin Neurol 20:326-30. 2007
    ..The International Headache Society revised the classification criteria. We provide a summary of the new findings and concepts...
  18. ncbi Advice alone vs. structured detoxification programmes for medication overuse headache: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs
    P Rossi
    Headache Clinic, INI Grottaferrata, Grottaferrata, Italy
    Cephalalgia 26:1097-105. 2006
    ..5% of patients in group A, 71.7% of patients in group B and 76.9% of those in group C (P>0.05). In patients with migraine plus MOH and low medical needs, effective drug withdrawal may be obtained through the imparting of advice alone...
  19. ncbi Cognitive functioning of long-term heavy cannabis users seeking treatment
    Nadia Solowij
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    JAMA 287:1123-31. 2002
    ..Cognitive impairments are associated with long-term cannabis use, but the parameters of use that contribute to impairments and the nature and endurance of cognitive dysfunction remain uncertain...
  20. ncbi Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Drug Alcohol Rev 26:25-31. 2007
    ..Efficacy of pharmacological and behavioral treatments that specifically target stress and cue-induced craving and arousal responses may also be assessed via alterations in these brain correlates...
  21. ncbi Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
    ..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues...
  22. ncbi PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Eur J Pharmacol 579:160-6. 2008
    ..Our findings suggest that chronic opioid use induces long-lasting striatum dopamine neuron impairment, and prolonged withdrawal from opioids can benefit the recovery of impaired dopamine neurons in the brain...
  23. pmc Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 325:302-12. 2008
    ....
  24. doi Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100, Murcia, Spain
    Naunyn Schmiedebergs Arch Pharmacol 378:407-20. 2008
    ..These results suggest that extracellular signal-regulated kinases1/2 signaling pathway is necessary for morphine withdrawal-induced activation of brain areas associated with the stress system...
  25. pmc Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence
    John P Welsh
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 108:10314-9. 2011
    ..Bidirectional plasticity of two hyperpolarization-sensitive currents following chronic ethanol abuse and abstinence may underlie persistent brain dysfunction in primates and be a target for therapy...
  26. pmc A within-subject comparison of withdrawal symptoms during abstinence from cannabis, tobacco, and both substances
    R G Vandrey
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 92:48-54. 2008
    ..Additional research is needed to replicate these findings and to further investigate the effects of abstaining from multiple drugs simultaneously...
  27. ncbi Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors
    M A Prendergast
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neuroscience 124:869-77. 2004
    ..These data suggest that neurodegeneration observed during ethanol withdrawal is dependent upon polysynaptic propagation of action potentials ("network excitation") and whole-hippocampal excitation of glutamatergic systems...
  28. ncbi Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers
    Jie Shi
    Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 87:141-5. 2007
    ..PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence...
  29. pmc 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 204:25-35. 2009
    ..Exposure to smoking-related cues can trigger relapse in smokers attempting to maintain abstinence...
  30. pmc Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell
    Ruth Sharf
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:175-83. 2008
    ..Although a role for orexin has been shown in reward and dependence, the molecular and neural mechanisms are unclear. We investigated the mechanism and neuroanatomic basis of orexin's role in morphine withdrawal...
  31. ncbi Reduced cardio-respiratory coupling in acute alcohol withdrawal
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, Jena, Germany
    Drug Alcohol Depend 98:210-7. 2008
    ..Since linear analysis of heart rate variability may not be entirely adequate to detect such autonomic dysfunction in acute alcohol withdrawal, we applied novel non-linear parameters and measures for cardio-respiratory coupling...
  32. ncbi Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors
    Yu Fu
    Department of Pharmacology and Toxicology, Medical Branch, University of Texas, 301 University Blvd, Galveston, TX 77555 1031, USA
    J Neurophysiol 97:937-41. 2007
    ..We suggest that these signaling mechanisms may provide therapeutic targets for the treatment of cocaine cravings...
  33. doi Restricted role of CRF1 receptor for the activity of brainstem catecholaminergic neurons in the negative state of morphine withdrawal
    Juan Antonio Garcia-Carmona
    Department of Pharmacology, Faculty of Medicine, University of Murcia, 30100, Murcia, Spain
    Psychopharmacology (Berl) 220:379-93. 2012
    ..Evidence suggests that corticotropin-releasing factor (CRF) system is an important mediator in the negative symptoms of opioid withdrawal...
  34. pmc Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction
    M J Christie
    Pain Management Research Institute and Kolling Institute, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia
    Br J Pharmacol 154:384-96. 2008
    ....
  35. ncbi 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  36. ncbi Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal
    Francesco Papaleo
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Neuron 53:577-89. 2007
    ..The present findings unravel a key role for the hypothalamus-pituitary-adrenal (HPA) system and brain extra-hypothalamic CRF/CRF1 receptor circuitry in somatic, molecular, and endocrine alterations induced by opiate withdrawal...
  37. ncbi Addiction motivation reformulated: an affective processing model of negative reinforcement
    Timothy B Baker
    Department of Psychology, University of Wisconsin Madison, Madison, WI 53711 2027, USA
    Psychol Rev 111:33-51. 2004
    ..After explicating their model, the authors address previous critiques of negative reinforcement models in light of their reformulation and review predictions generated by their model...
  38. ncbi Cannabis withdrawal among non-treatment-seeking adult cannabis users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 6823, USA
    Am J Addict 15:8-14. 2006
    ....
  39. ncbi Nicotine dependence and reward differ between adolescent and adult male mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 322:399-407. 2007
    ..These data indicate that the underlying receptor mechanisms of nicotine dependence differ for adults and adolescents, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups...
  40. pmc Prefrontal cortical dysfunction in abstinent cocaine abusers
    Karen Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Neuropsychiatry Clin Neurosci 16:456-64. 2004
    ..Since impairment in ECF may be a common feature of various neuropsychiatric disorders, these findings have applicability beyond the neurobiology of addiction...
  41. pmc Incubation of cue-induced cigarette craving during abstinence in human smokers
    Gillinder Bedi
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 69:708-11. 2011
    ..It is unknown whether cue-induced craving increases, decreases, or remains constant with abstinence in humans. We investigated effects of abstinence on cue-induced craving in cigarette smokers...
  42. doi First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction
    Frédéric Lemesle
    Amilly Hospital, France
    Am J Emerg Med 28:387.e5-6. 2010
    ..To our knowledge, this is the first case of stress cardiomyopathy described after abrupt opiate withdrawal secondary to a drug-drug interaction...
  43. doi Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal
    Javier Navarro-Zaragoza
    Department of Pharmacology, University School of Medicine, University of Murcia, Murcia, Spain
    Mol Pharmacol 77:864-73. 2010
    ..However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawal-activation of brain stress neurocircuitry...
  44. doi Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats
    Brandon J Hall
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Neurosci Lett 474:84-7. 2010
    ..These results provide proof of concept for the development and use of cholinergic compounds in the treatment of substance abuse...
  45. doi The Cannabis Withdrawal Scale development: patterns and predictors of cannabis withdrawal and distress
    David J Allsop
    National Cannabis Prevention and Information Centre, University of New South Wales, Sydney 2031, Australia
    Drug Alcohol Depend 119:123-9. 2011
    ..The aim is to develop and test the psychometrics of the Cannabis Withdrawal Scale and use it to explore predictors of cannabis withdrawal...
  46. pmc Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers
    Kenneth H Levin
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:120-7. 2010
    ..Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance...
  47. pmc Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD
    M Julia Garcia-Fuster
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 36:2303-17. 2011
    ....
  48. pmc Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish
    Priya Mathur
    Department of Bioengineering and Therapeutic Sciences, Programs in Biological Sciences and Human Genetics, University of California, San Francisco, CA 94143 2811, United States
    Behav Brain Res 219:234-9. 2011
    ....
  49. ncbi The marijuana withdrawal syndrome: diagnosis and treatment
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Curr Psychiatry Rep 7:360-6. 2005
    ..The objective of this review is to update clinicians on the current state of marijuana research and to describe features of marijuana withdrawal to facilitate the diagnosis and treatment of cannabis use disorders...
  50. pmc Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Thorax 60:480-7. 2005
    ..Combined treatment with ICS and long acting beta2 agonists (LABA) may provide benefit to the stability of COPD, but it is unknown if withdrawal of ICS will result in disease deterioration...
  51. ncbi Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 18:262-70. 2008
    ..Chronic craving and anhedonia were positively correlated with DA release. Treatment strategies that increase D2Rs may, therefore, be an interesting approach to prevent relapse in opiate addiction...
  52. pmc Influence of phase-related variability in premenstrual symptomatology, mood, smoking withdrawal, and smoking behavior during ad libitum smoking, on smoking cessation outcome
    Sharon S Allen
    Tobacco Use Research Center, University of Minnesota, Medical School, 2701 University Avenue SE, Suite 201, Minneapolis, MN 55414, United States
    Addict Behav 34:107-11. 2009
    ..These data support the inference that sex hormones influence smoking cessation outcome. This knowledge may contribute to the development of more rational and effective smoking cessation interventions for women...
  53. ncbi Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Department of Neurology, Emeryville, CA 94608, USA
    J Neurophysiol 98:2297-310. 2007
    ....
  54. pmc The endogenous cannabinoid system modulates nicotine reward and dependence
    Lisa L Merritt
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 326:483-92. 2008
    ..Taken together, these results support the hypothesis that cannabinoid receptor antagonists may offer therapeutic advantages to treat tobacco dependence...
  55. ncbi Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study
    Dharma McBride
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuropsychopharmacology 31:2728-38. 2006
    ..Our findings confirm the importance of expectancy in the neural response to drug cues, and lend support to the theory that these cues act on brain areas involved in arousal and attention...
  56. pmc Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:18156-61. 2012
    ....
  57. pmc Cannabis withdrawal in adolescent treatment seekers
    Ryan Vandrey
    Department of Psychology and Psychiatry, University of Vermont, 54 W Twin Oaks Terrace, Suite 12, S Burlington, VT 05403, USA
    Drug Alcohol Depend 78:205-10. 2005
    ..Addiction 94, 1311-1322]. Further research is needed to elucidate associations between cannabis withdrawal effects, the initiation of cessation attempts, and relapse...
  58. doi Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice
    Tanja Kivinummi
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Neurosci Lett 491:108-12. 2011
    ..In conclusion, the current results suggest the involvement of BDNF- and CREB-related neuronal processes in nicotine-induced neurochemical, behavioural, and neuroplastic changes in dopaminergic neurocircuits...
  59. ncbi The early time course of smoking withdrawal effects
    Peter S Hendricks
    Department of Psychology, University of South Florida, Tampa, FL 33617, USA
    Psychopharmacology (Berl) 187:385-96. 2006
    ..The literature contains a range of estimates about the early appearance of withdrawal symptoms, but without reference to empirical data...
  60. ncbi Pre-cessation nicotine replacement therapy: pragmatic randomized trial
    Chris Bullen
    Clinical Trials Research Unit, School of Population Health, The University of Auckland, Auckland, New Zealand
    Addiction 105:1474-83. 2010
    ..To determine the effectiveness of 2 weeks' pre-cessation nicotine patches and/or gum on smoking abstinence at 6 months...
  61. ncbi Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
    ..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence...
  62. doi Effectiveness of current treatment approaches for benzodiazepine discontinuation: a meta-analysis
    Jannette M Parr
    School of Medicine, University of Queensland, Herston, Queensland, Australia
    Addiction 104:13-24. 2009
    ..To assess the effectiveness of current treatment approaches to assist benzodiazepine discontinuation...
  63. ncbi Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness
    P Zeeberg
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 26:1192-8. 2006
    ..According to the International Classification of Headache Disorders, 2nd edn, the MOH diagnosis requires improvement after drug withdrawal. Our data suggest that these diagnostic criteria are too strict...
  64. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
    ..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol...
  65. ncbi Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
    A Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
    Neuropharmacology 43:857-67. 2002
    ..These results demonstrate that some acute effects and motivational responses elicited by nicotine can be modulated by the endogenous cannabinoid system and support the existence of a physiological interaction between these two systems...
  66. ncbi Marijuana abstinence effects in marijuana smokers maintained in their home environment
    A J Budney
    Department of Psychiatry, The University of Vermont, 54 W Twin Oaks Terr, Suite 9, S Burlington, VT 05403, USA
    Arch Gen Psychiatry 58:917-24. 2001
    ..This controlled outpatient study examined the reliability and specificity of the abstinence effects that occur when daily marijuana users abruptly stop smoking marijuana...
  67. pmc Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist
    George R Breese
    Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 29:470-82. 2004
    ....
  68. ncbi Effect of alcohol detoxification on serum S-100B levels of alcohol-dependent individuals
    Ioannis Liappas
    Department of Psychiatry, Eginition Hospital, University of Athens Medical School, Athens, Greece
    In Vivo 20:675-80. 2006
    ..The aim of this study was to evaluate the serum levels of S100B in alcohol-dependent individuals and to further investigate the effect of alcohol detoxification on the levels of S100B...
  69. pmc Withdrawal from long-term benzodiazepine use: randomised trial in family practice
    Catalina Vicens
    Centre de Salut Son Serra la Vileta, Family and Community Medicine Teaching Unit Palma de Mallorca, Mallorca, Spain
    Br J Gen Pract 56:958-63. 2006
    ..Withdrawing patients from these drugs is often difficult. Tapering off benzodiazepines has been shown to be a good strategy for discontinuing their long-term use...
  70. ncbi Rapid suppression of alcohol withdrawal syndrome by baclofen
    Giovanni Addolorato
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Am J Med 112:226-9. 2002
  71. ncbi A specific limbic circuit underlies opiate withdrawal memories
    Francois Frenois
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 5541 Interactions Neuronales et Comportements, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    J Neurosci 25:1366-74. 2005
    ..This first study on the neural substrates of withdrawal memories strongly supports an incentive-motivational view of withdrawal in opiate addiction that could be crucial in compulsive drug seeking and relapse...
  72. pmc A randomized clinical trial of St. John's wort for smoking cessation
    Amit Sood
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Altern Complement Med 16:761-7. 2010
    ..St. John's wort (SJW) is a widely used herbal supplement. The predominant mechanism(s) accounting for the activity of SJW in vivo are, however, unclear. The purpose of this study was to investigate the efficacy of SJW for smoking cessation...
  73. ncbi Withdrawal from alcohol using monitored alcohol consumption: a case report
    Neil R Wright
    Nottingham Alcohol and Drug Team, The Wells Road Centre, The Wells Road, Nottingham NG3 3AA and Sneinton Hermitage, 35 37 Sneinton Hermitage, Sneinton, Nottingham NG2 4BT, UK
    Alcohol Alcohol 37:344-6. 2002
    ..A single case study of alcohol withdrawal through monitored alcohol consumption in a hostel resident...
  74. ncbi Pharmacological approaches to the management of alcohol addiction
    G Addolorato
    Istituto di Medicina Interna, Universita Cattolica del Sacro Cuore, Roma
    Eur Rev Med Pharmacol Sci 6:89-97. 2002
    ..However, pharmacotherapy should not be considered as the only form of treatment but as an integrated part of a multimodal approach including psychological and social support...
  75. ncbi Medications acting on the GABA system in the treatment of alcoholic patients
    Fabio Caputo
    Department of Internal Medicine, SS Annunziata Hospital, Via Vicini 2, 44042, Cento Ferrara, Italy
    Curr Pharm Des 16:2118-25. 2010
    ..Thus, given the importance of GABA-ergic mechanisms in the development and maintenance of alcohol dependence, and the very interesting results currently achieved, more research on GABAergic agents is warranted...
  76. doi Alcohol dependence: analysis of factors associated with retention of patients in outpatient treatment
    Márcia Fonsi Elbreder
    Alcohol and Drugs Research Unit Uniad, Rua Botucatu 394 Vila Clementino CEP 04023 061, Sao Paulo SP, Brazil
    Alcohol Alcohol 46:74-6. 2011
    ..To identify factors associated with retention in treatment of alcohol-dependent individuals and to compare treatment retention between men and women...
  77. ncbi Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses
    Maurizio A Leone
    SCDU Neurologia, , C Mazzini 18, 28100 Novara, Italy
    Cochrane Database Syst Rev 2:CD006266. 2010
    ..Side effects of GHB are not statistically different from those with BZD, NTX or Disulfiram. However, concern has been raised regarding the risk of developing addiction, misuse or abuse, especially in polydrug abusers...
  78. ncbi Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency
    C V McMillan
    Royal Holloway, University of London, Egham, Surrey, UK
    Clin Endocrinol (Oxf) 59:467-75. 2003
    ..The objective of this study was to investigate the psychological effects of discontinuation of GH replacement from adults with severe GH deficiency (GHD)...
  79. ncbi Smoking cessation and smoking patterns in the general population: a 1-year follow-up
    R West
    St George s Hospital Medical School, Cranmer Terrace, London, UK
    Addiction 96:891-902. 2001
    ....
  80. ncbi Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:231-42. 2006
    ..Study findings require confirmation in additional larger samples before they are applied in practice...
  81. ncbi Nicotine withdrawal symptoms following a quit attempt: an ecological momentary assessment study among adolescents
    Rinka M P Van Zundert
    Behavioural Science Institute, Radboud University, PO Box 9104, Nijmegen 6500 HE, The Netherlands
    Nicotine Tob Res 11:722-9. 2009
    ..The present study describes growth curves of withdrawal symptoms among 138 daily smoking adolescents before, during, and after a quit attempt...
  82. ncbi Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:1203-11. 2006
    ....
  83. pmc Dialectical behavior therapy for substance abusers
    Linda A Dimeff
    Behavioral Tech Research, Inc, Seattle, Washington 98105, USA
    Addict Sci Clin Pract 4:39-47. 2008
    ..The treatment also may be helpful for patients who have other severe disorders co-occurring with SUDs or who have not responded to other evidence-based SUD therapies...
  84. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..In addition, nicotine withdrawal selectively affects acquisition but not recall or expression of the learned response...
  85. pmc The search for medications to treat stimulant dependence
    Kyle M Kampman
    University of Pennsylvania School of Medicine and Treatment Research Center, Philadelphia, Pennsylvania 19104, USA
    Addict Sci Clin Pract 4:28-35. 2008
    ..Treatment approaches that combine efficacious medications and empirically proven behavioral interventions, such as voucher-based reinforcement therapy, will almost certainly produce the best results...
  86. ncbi Opioids and abnormal pain perception: New evidence from a study of chronic opioid addicts and healthy subjects
    Dorit Pud
    Faculty of Social Welfare and Health Studies, University of Haifa, Israel Haifa Pain Research Group, Israel
    Drug Alcohol Depend 82:218-23. 2006
    ..In addition, it appears that detoxification from opioids does not reset pain perception for at least 1 month...
  87. doi Varenicline in prevention of relapse to smoking: effect of quit pattern on response to extended treatment
    Peter Hajek
    Wolfson Institute of Preventive Medicine, UK Centre for Tobacco Control Studies, Barts and The London, Queen Mary University of London, London E1 2AD, UK
    Addiction 104:1597-602. 2009
    ..In this secondary analysis, trial data were examined to see whether smokers who manage to achieve abstinence only later in the original course of treatment are more likely to benefit from having the course extended...
  88. pmc Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders
    Andrea H Weinberger
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 108:7-12. 2010
    ..The current study examined tobacco withdrawal symptoms and withdrawal-related discomfort and relapse in smokers with and without current mood disorders, anxiety disorders, alcohol use disorders (AUD), and substance use disorders (SUD)...
  89. ncbi A comparison of the psychometric properties of three cigarette withdrawal scales
    Jean Francois Etter
    Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Addiction 101:362-72. 2006
    ..To compare the psychometric properties of three cigarette withdrawal scales...
  90. ncbi In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone
    J McCambridge
    National Addiction Centre, Institute of Psychiatry, King s College London, 4 Windsor Walk, Camberwell, London SE5 8AF, United Kingdom
    Drug Alcohol Depend 88:91-5. 2007
    ..A cohort study design was used with double-blind random allocation to lofexidine+naloxone versus lofexidine+placebo. Patients who did not consent to, or who were excluded from randomisation received methadone...
  91. ncbi Opioid effects and opioid withdrawal during a 24 h dosing interval in patients maintained on buprenorphine
    Olga V Lopatko
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, SA, Australia
    Drug Alcohol Depend 69:317-22. 2003
    ....
  92. ncbi Physiologic mechanisms underlying the antidepressant discontinuation syndrome
    Pierre Blier
    Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Psychiatry 67:8-13. 2006
    ..It also attempts to explain their implications in the therapeutic actions of antidepressants in patients with affective and anxiety disorders...
  93. pmc Nicotine withdrawal and agitation in ventilated critically ill patients
    Olivier Lucidarme
    Service de Reanimation Polyvalente, CH mémorial France Etats Unis de Saint Lô, Saint Lô, France
    Crit Care 14:R58. 2010
    ....
  94. ncbi The place of detoxification in treatment of opioid dependence
    Linda R Gowing
    Drug and Alcohol Services South Australia, Australia
    Curr Opin Psychiatry 19:266-70. 2006
    ..This review summarizes current research on the management of opioid withdrawal and considers the selection of the approach in different situations...
  95. ncbi Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    JAMA 294:903-13. 2005
    ..Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence...
  96. ncbi Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement
    D Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Behav Pharmacol 13:389-96. 2002
    ..Thus, the type of self-administration history and the length of deprivation experienced contribute to changes in the reinforcing efficacy of cocaine as measured by a PR schedule...
  97. ncbi GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
    ..The increase may be mediated in part by functional desensitization of GABA(B) receptors, likely the result of diminished Ser phosphorylation of the GABA(B2) receptor...
  98. ncbi High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:202-12. 2002
    ..The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin...
  99. ncbi Ultra-rapid opiate detoxification using deep sedation and prior oral buprenorphine preparation: long-term results
    C Bochud Tornay
    Department of Adult Psychiatry, Cery Hospital, 1008, Prilly Lausanne, Switzerland
    Drug Alcohol Depend 69:283-8. 2003
    ..Premedication with buprenorphine has been advocated to improve safety by decreasing vomiting. Prior research has not explored URD in socially impaired patients...
  100. ncbi Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration
    M Scott Bowers
    Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB Suite 403, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 17:1273-8. 2003
    ..Furthermore, the increase in GFAP may arise from regionally distinct mechanisms, with the NAcore relying more on cell proliferation while the PFC relies on a larger reactive astrocyte population...
  101. ncbi Incubation of cocaine craving after withdrawal: a review of preclinical data
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:214-26. 2004
    ..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas...

Research Grants138 found, 100 shown here

  1. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2004
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  2. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2004
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  3. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  4. Human Laboratory Studies for Stimulant Addiction
    Mehmet Sofuoglu; Fiscal Year: 2008
    ..This K02 application will provide support for the candidate's sustained research in areas of cocaine and nicotine addiction. ..
  5. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2008
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  6. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  7. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  8. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  9. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2008
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  10. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  11. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2003
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  12. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  13. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2005
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  14. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2003
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  15. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2004
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  16. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2003
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  17. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2003
    ....
  18. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2009
    ....
  19. Central mechanisms of nicotine reinforcement and dependence
    George Koob; Fiscal Year: 2009
    ....
  20. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2002
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  21. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2002
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  22. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2008
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  23. Central Mechanisms of Opiate Reinforcement and Dependen*
    George Koob; Fiscal Year: 2005
    ....
  24. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2008
    ..neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment [unreadable] [unreadable]..
  25. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2008
    ....
  26. Neurpsychopharmacology-Multidisciplinary Training
    George Koob; Fiscal Year: 2008
    ..In summary, the training program discussed herein provides a dynamic environment for fellows to develop a strong foundation to pursue a career in the neuropsychopharmacology of alcoholism. ..
  27. Integrative Neuroscience Initiative on Alcoholism
    George Koob; Fiscal Year: 2007
    ..The INIA program will be directed by an Administrative Core in close cooperation with the Executive Committee, Steering Committee, and with the continual advice of the Scientific Advisory Board. [unreadable] [unreadable] [unreadable]..
  28. Neurpsychopharmacology-Multidisciplinary Training
    George Koob; Fiscal Year: 2007
    ..In summary, the training program discussed herein provides a dynamic environment for fellows to develop a strong foundation to pursue a career in the neuropsychopharmacology of alcoholism. ..
  29. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2007
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  30. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2007
    ....
  31. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2007
    ..neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment [unreadable] [unreadable]..
  32. Central Mechanisms of Opiate Reinforcement and Dependen*
    George Koob; Fiscal Year: 2006
    ....
  33. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2006
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  34. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2006
    ..neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment [unreadable] [unreadable]..
  35. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2002
    ....
  36. Central Mechanisms of Opiate Reinforcement /Dependence
    George Koob; Fiscal Year: 2004
    ....
  37. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1999
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  38. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1991
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  39. NEURONAL SUBSTRATES OF COCAINE REWARD
    George F Koob; Fiscal Year: 2010
    ....
  40. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1990
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  41. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1992
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  42. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1990
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  43. Central mechanisms of nicotine reinforcement and dependence
    George Koob; Fiscal Year: 2009
    ..abstract_text> ..
  44. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 1991
    ..These results should have important implications not only for our understanding of the neurobiology of ethanol intoxication but may lead to the development of viable pharmacological intervention in alcoholism...
  45. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1993
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  46. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2000
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  47. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 1999
    ....
  48. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2001
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  49. DOPAMINE PARTIAL AGONISTS AND COCAINE DEPENDENCE
    George Koob; Fiscal Year: 1999
    ..These studies will help elucidate the effectiveness of dopamine partial agonists with a wide range of intrinsic efficacies in modifying various phases of the natural history of psychostimulant dependence. ..
  50. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2001
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..
  51. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2001
    ....
  52. Central mechanisms of nicotine reinforcement and dependence
    George F Koob; Fiscal Year: 2010
    ....
  53. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2000
    ....
  54. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1991
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  55. Integrative Neuroscience Initiative on Alcoholism
    George Koob; Fiscal Year: 2008
    ..The INIA program will be directed by an Administrative Core in close cooperation with the Executive Committee, Steering Committee, and with the continual advice of the Scientific Advisory Board. ..
  56. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2007
    ....
  57. Integrative Neuroscience Initiative on Alcoholism - West - Supplement
    George Koob; Fiscal Year: 2008
    ..abstract_text> ..
  58. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George Koob; Fiscal Year: 2008
    ..Training and information dissemination to the San Diego community will be effected by the training opportunities of the Center including an NIAAA training grant and the Education Component. ..
  59. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George Koob; Fiscal Year: 2007
    ..Training and information dissemination to the San Diego community will be effected by the training opportunities of the Center including an NIAAA training grant and the Education Component. ..
  60. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2009
    ....
  61. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2009
    ....
  62. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1992
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  63. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2004
    ..data to understand the neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment ..
  64. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1993
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  65. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2005
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  66. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2005
    ..data to understand the neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment ..
  67. Central mechanisms of nicotine reinforcement and dependence
    George Koob; Fiscal Year: 2008
    ....
  68. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence H Sweet; Fiscal Year: 2011
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  69. Genetics, Brain Activity, and Relapse to Alcoholism
    Kirk Brower; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  70. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence Sweet; Fiscal Year: 2009
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  71. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2008
    ..These novel treatments may aid in improving smoking cessation rates. ..
  72. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk J Brower; Fiscal Year: 2010
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  73. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    KELLY COSGROVE; Fiscal Year: 2009
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
  74. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2008
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  75. Dissemination of a Smoking Quitline to the Underserved
    JENNIFER VIDRINE; Fiscal Year: 2008
    ..Thus, findings are likely to have a significant public health impact. ..
  76. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    Kelly P Cosgrove; Fiscal Year: 2010
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
  77. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2009
    ..These novel treatments may aid in improving smoking cessation rates. ..
  78. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2009
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  79. Brain Imaging of Sex Differences in Tobacco Smokers
    KELLY COSGROVE; Fiscal Year: 2008
    ..This will aid in the development of medications that are specifically designed to help both women and men quit smoking. ..
  80. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2009
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  81. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence H Sweet; Fiscal Year: 2010
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  82. Medication Effects on Sleep in Alcoholics
    Kirk Brower; Fiscal Year: 2008
    ..He will apply these methods to alcohol dependent patients, an understudied population that may benefit clinically from a more sophisticated understanding of their sleep problems. ..
  83. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  84. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2010
    ..These novel treatments may aid in improving smoking cessation rates. ..
  85. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2007
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. [unreadable] [unreadable] [unreadable]..
  86. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2007
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  87. Health Communications and Risk Processing Among Smokers
    JENNIFER VIDRINE; Fiscal Year: 2006
    ..Findings have the potential to shed light on important mechanisms that may influence the construction of risk perceptions and on how perceptions of risk and smoking behavior may be reciprocally related. ..
  88. TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
    KELLY COSGROVE; Fiscal Year: 2002
    ..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
  89. Ecology Momentary Assessment of College Smoking
    THOMAS PIASECKI; Fiscal Year: 2003
    ..This project has the potential to address key questions about the early smoking career in a population at risk for the development of chronic tobacco dependence. ..
  90. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..