lathyrism

Summary

Summary: A paralytic condition of the legs caused by ingestion of lathyrogens, especially beta-aminopropionitrile, found in the seeds of plants of the genus Lathyrus (see FABACEAE).

Top Publications

  1. ncbi Prevention of neurolathyrism during drought
    S L N Rao
    Lancet 363:657. 2004
  2. ncbi New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in north west Bangladesh
    A Haque
    Department of Neurology, Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh
    Paraplegia 32:193-5. 1994
  3. doi A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass pea
    S L N Rao
    Department of Biochemistry, Osmania University, Hyderabad, India
    Food Chem Toxicol 49:620-2. 2011
  4. doi The nutritive value of grasspea (Lathyrus sativus) and allied species, their toxicity to animals and the role of malnutrition in neurolathyrism
    Dirk Enneking
    Department of Education and Children s Services, Kangaroo Inn Area School, South Australia, Australia
    Food Chem Toxicol 49:694-709. 2011
  5. doi Brain glutathione as a target for aetiological factors in neurolathyrism and konzo
    Peter B Nunn
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
    Food Chem Toxicol 49:662-7. 2011
  6. doi A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents
    Jordi Llorens
    Departament de Ciències Fisiològiques II, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Food Chem Toxicol 49:563-70. 2011
  7. ncbi BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacing
    S Lees
    Bioengineering Department, Forsyth Dental Center, Boston, MA 02115
    Connect Tissue Res 24:95-105. 1990
  8. ncbi The role of ascorbic acid on collagen structure and levels of serum interleukin-6 and tumour necrosis factor-alpha in experimental lathyrism
    N Senturk
    Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Clin Exp Dermatol 29:168-75. 2004
  9. ncbi Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine
    Haileyesus Getahun
    South Gonder Health Department, Debre Tabor, Amhara Regional State, Ethiopia Ghent University, Ghent, Belgium
    Lancet 362:1808-10. 2003
  10. ncbi Prevention of neurolathyrism during drought
    Fernand Lambein
    Lancet 363:657. 2004

Research Grants

  1. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
  2. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
  3. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL TSHALA KATUMBAY; Fiscal Year: 2009
  4. PLANT TOXINS AND DEMENTIA IN THE WESTERN PACIFIC
    TOM MABRY; Fiscal Year: 1992
  5. TOXIC PROBES OF NEURODEGENERATIVE DISEASES
    Peter Spencer; Fiscal Year: 1991
  6. CHRONIC NEUROTOXICITY OF BMAA AND NON NMDA AGONISTS
    John Weiss; Fiscal Year: 1990
  7. (NEURO)TOXICOGENOMICS AND CHILD HEALTH
    Peter Spencer; Fiscal Year: 2005
  8. NEUROTOXIC SUPERFUND CHEMICALS AND BIOMAKERS
    Peter Spencer; Fiscal Year: 2007
  9. Mixture Toxicity - Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2008
  10. Mixture Toxicity: Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications96

  1. ncbi Prevention of neurolathyrism during drought
    S L N Rao
    Lancet 363:657. 2004
  2. ncbi New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in north west Bangladesh
    A Haque
    Department of Neurology, Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh
    Paraplegia 32:193-5. 1994
    ..Sporadic occurrence of HTLV-1 infection (0.9%) and of osteolathyrism was found among the neurolathyrism patients. Osteolathyrism is linked to the consumption of the green shoots of Lathyrus sativus...
  3. doi A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass pea
    S L N Rao
    Department of Biochemistry, Osmania University, Hyderabad, India
    Food Chem Toxicol 49:620-2. 2011
    ..These novel approaches to both ODAP and homoarginine might entirely change our perception of this poor man's pulse...
  4. doi The nutritive value of grasspea (Lathyrus sativus) and allied species, their toxicity to animals and the role of malnutrition in neurolathyrism
    Dirk Enneking
    Department of Education and Children s Services, Kangaroo Inn Area School, South Australia, Australia
    Food Chem Toxicol 49:694-709. 2011
    ..Interruptions to these processes and excessive concurrent demands for reduced sulfur amino acids are likely to be conducive to the onset of neurotoxicity...
  5. doi Brain glutathione as a target for aetiological factors in neurolathyrism and konzo
    Peter B Nunn
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
    Food Chem Toxicol 49:662-7. 2011
    ....
  6. doi A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents
    Jordi Llorens
    Departament de Ciències Fisiològiques II, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Food Chem Toxicol 49:563-70. 2011
    Konzo and lathyrism are associated with consumption of cassava and grass pea, respectively. Cassava consumption has also been associated with a third disease, tropical ataxic neuropathy (TAN)...
  7. ncbi BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacing
    S Lees
    Bioengineering Department, Forsyth Dental Center, Boston, MA 02115
    Connect Tissue Res 24:95-105. 1990
    ..Much of the effects on bone properties occur at the higher BAPN dosages where overt osteolathyrism is observed and where there seem to be only small changes in crosslinking density...
  8. ncbi The role of ascorbic acid on collagen structure and levels of serum interleukin-6 and tumour necrosis factor-alpha in experimental lathyrism
    N Senturk
    Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Clin Exp Dermatol 29:168-75. 2004
    b>Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme essential for interfibrillar cross-linking...
  9. ncbi Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine
    Haileyesus Getahun
    South Gonder Health Department, Debre Tabor, Amhara Regional State, Ethiopia Ghent University, Ghent, Belgium
    Lancet 362:1808-10. 2003
    ..During famine, cereals and nutritional information should reach people before they have grass pea as the only food...
  10. ncbi Prevention of neurolathyrism during drought
    Fernand Lambein
    Lancet 363:657. 2004
  11. ncbi Periodontal & systemic bone changes in rats with experimental lathyrism
    Gonca Keles
    Ondokuzmayis University, Faculty of Dentistry, Department of Periodontology, Samsun, Istanbul, Turkey
    Indian J Med Res 123:541-6. 2006
    It is not clear how lathyrism affects the systemic bone metabolism...
  12. ncbi Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism
    M P Pratap Rudra
    Department of Biochemistry, Osmania University, Hyderabad 500007, India
    Clin Biochem 37:318-22. 2004
    ..sativus...
  13. ncbi A life-saving food plant producing more neurotoxin under environmental stress
    Asnake Fikre
    Institute Plant Biotechnology for Developing Countries, Ghent University, Belgium
    Commun Agric Appl Biol Sci 71:79-82. 2006
  14. ncbi Osteolathyrism in the rat: an X-ray diffraction study of collagen from normal and lathyritic rats. 1964
    Harold L Kundel
    Acad Radiol 9:570-9. 2002
  15. ncbi The effects of beta-aminopropionitrile on colonic anastomosis in rats
    Turker Bulut
    Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Turkey
    J Invest Surg 17:211-9. 2004
    ..If collagen synthesis could be altered to minimize the contracture, then the outcome could be improved. Lathyrism produces poorly cross-linked collagen in healing anastomosis, keeping a larger portion of the synthesized ..
  16. doi Chapter 50: history of tropical neurology
    Adesola Ogunniyi
    Department of Medicine, University College Hospital, Ibadan, Nigeria
    Handb Clin Neurol 95:815-30. 2010
    ..The story moved from lathyrism through Jamaican neuropathy to cassava-induced epidemic neuropathy, which was contrasted with Konzo, also ..
  17. pmc Production of diamino propionic acid ammonia lyase by a new strain of Salmonella typhimurium PU011
    K R Rupesh
    Department of Biotechnology, Pondicherry University, Kalapet, Pondicherry 605014, India
    BMC Microbiol 2:5. 2002
    ..DAP is a neurotoxin, which, when consumed, causes a disease called Lathyrism. Lathryrism may manifest as Neurolathyrism or Osteolathyrism, in which the nervous system, and bone formation ..
  18. ncbi Chemical studies on the cyanogen bromide peptides of rat skin collagen. The covalent structure of alpha 1-CB5, the major hexose-containing cyanogen bromide peptide of alpha 1
    W T Butler
    Biochemistry 9:44-50. 1970
  19. pmc Isolation of tropoelastin a from lathyritic chick aortae
    C B Rich
    Biochem J 217:581-4. 1984
    ..However, it differs from authentic tropoelastin b in containing a higher percentage of polar amino acids and cysteine residues. In addition, the amount of proline hydroxylation is 3 times higher than that found in chick tropoelastin b...
  20. ncbi Lathyrism, leg cramps, and thrombocytopenia: cascade of events starting in a concentration cAMP
    Erica Sigler
    Hematology Institute, Kaplan Medical Center, Rehovot, Israel
    Am J Med 120:e3. 2007
  21. ncbi Knowledge and management of disabling conditions in South Asian histories: implications for leprosy futures
    M Miles
    Indian J Lepr 75:153-67. 2003
    ..by reviewing the historical careers of four disabling conditions sharing some features with leprosy: lathyrism, iodine deficiency disorders (IDD), cataract and poliomyelitis...
  22. doi Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis
    Kimino Kawaguchi
    Laboratory of Biochemistry, School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Chiba 274 8555, Japan
    Biochem Biophys Res Commun 428:160-6. 2012
    ..The present data shed light on the role and the mechanism of vascular insult in causing dysfunction and moribund motor neurons in experimental NL...
  23. pmc The ratio 1660/1690 cm(-1) measured by infrared microspectroscopy is not specific of enzymatic collagen cross-links in bone tissue
    Delphine Farlay
    INSERM, UMR 1033, Lyon, France
    PLoS ONE 6:e28736. 2011
    ....
  24. ncbi Portosystemic myelopathy: spastic paraparesis after portosystemic shunting
    Harold O Conn
    Yale University School of Medicine, New Haven, Connecticut, USA
    Scand J Gastroenterol 41:619-25. 2006
    ..b>Lathyrism, a toxic syndrome with similar symptoms and signs, is caused by the ingestion of a legume, Lathyrus sativa, ..
  25. doi Role of glutamate and nitric oxide in onset of motor neuron degeneration in neurolathyrism
    Arjun L Khandare
    Food and Drug Toxicology Research Center, National Institute of Nutrition, Hyderabad 500007, India
    Neurotoxicology 34:269-74. 2013
    ..This review brings together all the molecular events reported so far, emphasizing on the possible role of glutamate and nitric oxide mediated cell death...
  26. doi Neurolathyrism: two Ethiopian case reports and review of the literature
    Yohannes W Woldeamanuel
    Department of Neurology, Addis Ababa University, Addis Ababa, Ethiopia
    J Neurol 259:1263-8. 2012
    ..Education, avoidance of the grasspea and measures to reduce toxin burden are possible methods...
  27. ncbi Metabolic and toxic myelopathies
    Neeraj Kumar
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Neurol 32:123-36. 2012
    ..or copper deficiency, disorders that have a geographical predilection and are due to a suspected toxin such as lathyrism, and disorders due to a possible toxin but without a geographical predilection such as hepatic myelopathy (Table ..
  28. pmc Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010
    Delphin Diasolua Ngudi
    Programme National de Nutrition, Kinshasa, Democratic Republic of the Congo
    PLoS Negl Trop Dis 6:e1759. 2012
    ..Konzo and neurolathyrism can be prevented by a balanced diet...
  29. doi Relevance of neuroimaging in the diagnosis and management of tropical neurologic disorders
    P Satishchandra
    Department of Neurology, NIMHANS, Bangalore, Karnataka, India
    Neuroimaging Clin N Am 21:737-56, vii. 2011
    ..Infections are more common in the tropics and require special attention in view of their potential treatability...
  30. doi Potentiation of neurotoxicity of Lathyrus sativus by manganese: alterations in blood-brain barrier permeability
    Geeta Mishra
    Food Toxicology Laboratory, Indian Institute of Toxicology Research, Council of Scientific Research, Mahatma Gandhi Marg, Lucknow, India
    Toxicol Mech Methods 19:318-26. 2009
    ..These results suggest that Mn may potentiate the neurotoxicity of lathyrus/ODAP by altering the BBB permeability...
  31. ncbi Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidants
    Haileyesus Getahun
    South Gondar Health Department, Debre Tabor, Ethiopia
    Trop Med Int Health 10:169-78. 2005
    ..To study an array of household individual and dietary risk factors for neurolathyrism...
  32. doi Towards the re-introduction of grass pea (Lathyrus sativus) in the West Balkan Countries: the case of Serbia and Srpska (Bosnia and Herzegovina)
    A Mikic
    Institute of Field and Vegetable Crops, Novi Sad, Serbia
    Food Chem Toxicol 49:650-4. 2011
    ..Grass pea is commonly used boiled and along with other pulses, with no reports on lathyrism among the local people...
  33. doi Assessing diet in populations at risk for konzo and neurolathyrism
    Darna L Dufour
    Department of Anthropology, University of Colorado, Boulder, Colorado 80309, USA
    Food Chem Toxicol 49:655-61. 2011
    ..objective of this paper is to discuss methods for assessing dietary intake in populations at risk for konzo and lathyrism. These methods include weighed food records and interview based techniques like 24-h recalls and food frequency ..
  34. doi Studies on neurolathyrism in Ethiopia: dietary habits, perception of risks and prevention
    A Fikre
    Ethiopian Institute for Agricultural Research, Debre Zeit Center, PO Box 32, Debre Zeit, Ethiopia
    Food Chem Toxicol 49:678-84. 2011
    ..This observation points to the correlation between low neurolathyrism incidence and a better balanced diet as well as metallic kitchen utensils, suggesting a new approach for neurolathyrism prevention...
  35. doi Effect of methionine supplement on physical responses and neurological symptoms in broiler chicks fed grass pea (Lathyrus sativus)-based starter ration
    Asnake Fikre
    Institute of Plant Biotechnology for Developing Countries IPBO, Ghent University, KL Ledeganckstraat 35, B 9000 Ghent, Belgium
    Food Chem Toxicol 48:11-7. 2010
    ..These results suggest that methionine can improve a grass pea-based diet for broiler chicks and especially can protect young chicks from neurological symptoms...
  36. ncbi [Describing neurolathyrism. Physicians and the lathyrism epidemic in post-civil war Spain]
    M I del Cura
    Departamento de Ciencias de la Salud I, Universidad Rey Juan Carlos, Madrid, Espana
    Rev Neurol 48:265-70. 2009
    b>Lathyrism is a chronic disease involving spastic paralysis of the lower limbs caused by the prolonged consumption of large amounts of flour made from grass pea, or almorta as it is known in Spain...
  37. ncbi Possible etiologies for tropical spastic paraparesis and human T lymphotropic virus I-associated myelopathy
    V Zaninovic'
    Neurologia Clinica, Universidad del Valle, Cali, Colombia
    Braz J Med Biol Res 37:1-12. 2004
    ..Glutamate-mediated excitotoxicity, central distal axonopathies, cassava, lathyrism and cycad toxicity may explain most cases of TSP...
  38. ncbi A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legs
    K Kusama-Eguchi
    Laboratory of Biology, Nihon University College of Pharmacy, Narashinodai, Funabashi, Japan
    Amino Acids 28:139-43. 2005
    ..032. These paralyzed rats displayed the severe atrophy of the ventral root of the lumbar cord as well as degenerations of motor neuron. The rats were useful models for the study of motor neuron degeneration in the spinal cord...
  39. doi Sulfur amino acids deficiency caused by grass pea diet plays an important role in the toxicity of L-β-ODAP by increasing the oxidative stress: studies on a motor neuron cell line
    Kuniko Kusama-Eguchi
    Research Unit of Biochemistry, School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba 274 8555, Japan
    Food Chem Toxicol 49:636-43. 2011
    ....
  40. ncbi Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord
    Kuniko Kusama-Eguchi
    Research Unit of Molecular Cell Biology, College of Pharmacy, Nihon University, Chiba 274 8555, Japan
    J Comp Neurol 518:928-42. 2010
    ..For the first time, we present a model of the early molecular events that occur during chemically induced spinal cord injury, which can potentially be applied to other neurodegenerative disorders...
  41. ncbi Ultrastructural and histomorphometric alterations of rat jaw bones after experimental induction of lathyrism
    Dalia H El Rouby
    Oral Pathology Department, Faculty of Oral and Dental Medicine, Cairo University, Egypt
    Arch Oral Biol 53:916-23. 2008
    ..The aim of this study was to investigate the effect of beta-aminopropionitrile (beta-APN), present in Lathyrus sativus (L. sativus) seeds consumed in drought prone areas, on the maxillary and mandibular bones of rats...
  42. pmc 50 years ago in CORR : skeletal lesions produced by aminonitriles by Ignacio V. Ponseti MD CORR 1957;9:131-144
    Ignacio V Ponseti
    Clin Orthop Relat Res 466:255-6. 2008
  43. ncbi Reduced reciprocal inhibition is seen only in spastic limbs in patients with neurolathyrism
    C Crone
    Department of Clinical Neurophysiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Exp Brain Res 181:193-7. 2007
    ..These findings are consistent with the hypothesis that reduced reciprocal inhibition plays a causal role in the pathophysiology of spasticity...
  44. doi Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanisms
    C J Jiao
    Key Laboratory of Arid Agroecology under the Ministry of Education Institute of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
    Food Chem Toxicol 49:543-9. 2011
    ..was considered responsible for human lathyrism. The levels of β-ODAP were reported to vary in different tissues during plant development, and to be affected ..
  45. ncbi Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from Ethiopia
    Yu Haey Kuo
    Laboratory of Physiological Chemistry, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    Clin Biochem 40:397-402. 2007
    ..The irreversibly crippling disease neurolathyrism is caused by prolonged over-consumption of Lathyrus sativus seed. The molecular mechanism of toxicity is unclear and more biochemical information is needed...
  46. ncbi The effect of lathyrism on dentin structure of the rat incisors: a morphometric and scanning electron microscopic investigation
    Dalia Hussein El Rouby
    Oral Pathology Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
    J Oral Pathol Med 39:424-30. 2010
    ..The present study was designed to study the effect of beta-aminopropionitrile (beta-APN), present in Lathyrus sativus grass pea consumed in drought prone areas, on dentin of the continuously erupting rat incisors...
  47. doi In search of a new therapeutic target for the treatment of genetically triggered thoracic aortic aneurysms and cardiovascular conditions: insights from human and animal lathyrism
    Hisham M F Sherif
    Department of Cardiac Surgery, Christiana Hospital, Christiana Care Health System, 4755 Ogletown Stanton Road, Suite 1E50, Newark, DE 19718, USA
    Interact Cardiovasc Thorac Surg 11:271-6. 2010
    b>Lathyrism, or the effect of certain plants on connective tissue disruption, particularly involving the vascular and skeletal systems, especially aortic dissection/rupture, has been well documented in animals...
  48. doi Genetic improvement of grass pea for low neurotoxin (β-ODAP) content
    Shiv Kumar
    Biodiversity and Integrated Gene Management Program, International Center for Agricultural Research in the Dry Areas, PO Box 5466, Aleppo, Syria
    Food Chem Toxicol 49:589-600. 2011
    ..low ODAP varieties, which along with improved agronomic and detoxification practices can help reduce the risk of lathyrism. Collaborative efforts between ICARDA and NARS have resulted in development of improved varieties such as Wasie ..
  49. ncbi Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes
    Lorraine Brennan
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Neurochem Int 48:739-45. 2006
    ..Collectively these results show that the gliotoxin, L-serine-O-sulphate, causes major disruptions to metabolic pathways in primary cultures of astrocytes...
  50. ncbi Determination of systemically & locally induced periodontal defects in rats
    Gonca Gonca Cayir Keles
    Ondokuzmayis University, Faculty of Dentistry, Department of Periodontology, Samsun, Istanbul, Turkey
    Indian J Med Res 121:176-84. 2005
    ..on bone metabolism is unclear, therefore we undertook this study to observe periodontal and systemic alterations in experimental lathyrism in rat and compare these changes to that observed in the locally induced periodontitis group.
  51. pmc Alteration of elastic architecture in the lathyritic rat aorta implies the pathogenesis of aortic dissecting aneurysm
    Y Nakashima
    First Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Am J Pathol 140:959-69. 1992
    ..These results suggest that the alteration of the elastic architecture causes an unstable connection between each elastic lamina, and is related to the initiation and the progression of dissecting aneurysm...
  52. pmc Peripheral and central conduction studies in neurolathyrism
    U K Misra
    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Neurol Neurosurg Psychiatry 57:572-7. 1994
    To study the involvement of motor and sensory pathways in neurolathyrism, 19 patients with lathyrism from Unnao, India, where lathyrism is endemic, were studied. The mean age of the patients at the time of the onset of illness was 35...
  53. ncbi Studies of the etiology and pathogenesis of motor neuron diseases. III. Magnetic cortical stimulation in patients with lathyrism
    J Hugon
    Department of Neurology, Limoges University Hospital, France
    Acta Neurol Scand 88:412-6. 1993
    ..of central motor pathways were conducted of 11 Spanish subjects with varying degrees of spastic paraparesis (lathyrism)...
  54. ncbi From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism
    F Lambein
    Laboratory of Physiological Chemistry, Faculty of Medicine, University of Gent, Belgium
    Toxicon 32:461-6. 1994
    ..zinc and with high iron content (Ethiopian vertisols), may be responsible for higher incidence of human lathyrism, one of the oldest neurotoxic diseases known to man...
  55. ncbi Emphysema-like changes in the lungs of the blotchy mouse
    D E Fisk
    Am Rev Respir Dis 113:787-97. 1976
    ..The Blotchy strain may be a useful model in which to investigate how abnormalities of connective tissue proteins influence pulmonary structure and function...
  56. ncbi In vitro toxicological investigations of isoxazolinone amino acids of Lathyrus sativus
    M Riepe
    Center for Research on Environmental and Occupational Toxicology, Oregon Health Sciences University, Portland 97201 3098, USA
    Nat Toxins 3:58-64. 1995
    ..These results suggest that Lathyrus sativus plants engineered to block the synthesis of beta-ODAP may accumulate a neurotoxic precursor and therefore must be tested for the presence of both BIA and beta-ODAP...
  57. ncbi The covalent structure of collagen: amino acid sequence of the N-terminal region of alpha2-CB3 from rat skin collagen and alpha2-CB3.5 from calf skin collagen
    P P Fietzek
    Hoppe Seylers Z Physiol Chem 355:647-50. 1974
  58. ncbi Experimental lathyrism: exostoses and aneurysmal-like bone cysts of the mandible in the rat
    E Baden
    College of Dental Medicine, Fairleigh Dickinson University, Hackensack, NJ
    Ann Pathol 7:297-303. 1987
    The effect of chronic lathyrism on the mandible of the rat was studied...
  59. ncbi Studies on the etiology and pathogenesis of motor neuron diseases. II. Clinical and electrophysiologic features of pyramidal dysfunction in macaques fed Lathyrus sativus and IDPN
    J Hugon
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
    Neurology 38:435-42. 1988
    A primate model of lathyrism has been produced in well-nourished male cynomolgus monkeys chronically fed a fortified diet composed of Lathyrus sativus (chickling or grass pea) and given daily per os an alcoholic extract of this legume...
  60. ncbi Prevalence of paralytic poliomyelitis in rural and urban populations in Ethiopia: report of a house-to-house survey
    M Maru
    Gondar College of Medical Sciences, Gondar Regional Health Department, Ethiopia
    Am J Trop Med Hyg 38:633-5. 1988
    ..Nineteen percent needed a stick support for walking while 12% were unable to walk even with support. This problem was more common in rural populations. The prevalence of paralytic poliomyelitis was 7.3/1,000 children 5-9 years old...
  61. ncbi Bronchial asthma caused by Lathyrus sativus flour
    R Valdivieso
    Servico de Alergia, Hospital Ramon y Cajal, Madrid, Spain
    Allergy 43:536-9. 1988
    ..Specific IgE antibodies to Lathyrus sativus flour was demonstrated by indirect enzyme immunoassay. We suggest that our patient's allergic symptoms were due to the development of Type I allergic reactivity to L. sativus antigens...
  62. ncbi Anti-nutritional and toxic factors in food legumes: a review
    Y P Gupta
    Division of Agricultural Biochemistry, Indian Agricultural Research Institute, New Delhi
    Plant Foods Hum Nutr 37:201-28. 1987
    ..These factors are shown to be widely present in leguminous foods which are important constituents of the diet of a large section of the world's population, and particularly, of people in the developing countries...
  63. ncbi The role of collagen crosslinking in the increased stiffness of avian dystrophic muscle
    H Feit
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202
    Muscle Nerve 12:486-92. 1989
    ..In separate experiments, lathyrism was induced by treating normal (412/412) and dystrophic (413/413) chickens with alpha-acetoaminonitrile, an ..
  64. ncbi Comparison of the effects of two lathyrogens on the reproductive system of the laying hen
    S D Chowdhury
    Department of Poultry Science, Bangladesh Agricultural University, Mymensingh
    Vet Rec 124:240-2. 1989
    ..The reduced egg production after feeding beta-aminopropionitrile was due to the reduced growth rate of the ovary, and in the case of semicarbazide, to the atresia of large yolky follicles...
  65. ncbi Effect of lathyrogen on collagen of methylcholanthrene-induced sarcoma of rat
    E Bankowski
    Department of Biochemistry, Medical Academy of Białystok, Poland
    Zentralbl Allg Pathol 136:247-53. 1990
    ..Although lathyrogen had no significant effect on the growth and overall size of fibrosarcoma, histological studies confirmed that changes had occurred to appearance and distribution of collagenous components of extracellular matrix...
  66. ncbi Electrophysiologic features in patients with chronic neurolathyrism
    V E Drory
    Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Acta Neurol Scand 85:401-3. 1992
    ..Two of them (25%) showed electrophysiological signs of lower motor neuron disease in their lower limbs. Subclinical affection of the anterior horn cells occurs probably more frequently than expected in chronic neurolathyrism...
  67. ncbi Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder
    R T Haimanot
    Faculty of Medicine, Addis Ababa University, Ethiopia
    Int J Epidemiol 19:664-72. 1990
    b>Lathyrism is a disorder of the central motor system, induced by heavy consumption of the grass-pea, Lathyrus sativus an environmentally tolerant legume containing the neurotoxic excitatory amino acid beta-N-oxalylamino-L-alanine (BOAA)...
  68. ncbi Reliability of eruption rate measurements of the rat incisor
    A A Taverne
    University of Queensland Dental School, Brisbane
    Aust Orthod J 12:33-6. 1991
    ..It furthermore provides an excellent method to assess the lathyrogenic condition of these animals...
  69. ncbi Effects of lathyritic drugs and lathyritic demineralized bone matrix on induced and sustained osteogenesis
    P E Di Cesare
    Cartilage and Bone Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003
    J Orthop Res 12:395-402. 1994
    ..These results indicate that the degree of crosslinking of the collagen matrix that acts as a carrier for osteoinductive proteins plays a key role in inducing and sustaining osteogenesis...
  70. ncbi Collagen responsible for tooth eruption? A study of the eruption of rat incisors
    A A Taverne
    Division of Orthodontics, Pediatric Dentistry and Community Dentistry, Department of Dentistry, University of Qld Dental School, Brisbane, Australia
    Aust Orthod J 12:199-206. 1993
    ..As the collagen protein seems to play a key role in tooth eruption, the investigation concentrated on the presence and maturation of collagen and its possible function in the process of tooth eruption...
  71. ncbi The epidemiology of lathyrism in north and central Ethiopia
    R T Haimanot
    Faculty of Medicine, Addis Abeba University, Ethiopia
    Ethiop Med J 31:15-24. 1993
    b>Lathyrism is a neurotoxic disorder caused by excessive, prolonged consumption of the hardy, environmentally tolerant legume, the grass-pea, Lathyrus sativus, which contains the neurotoxic amino acid beta-N-oxalylamino-L-alanine acid (..
  72. ncbi Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus development
    M A Cotter
    Department of Biology Toxicology, 401 College Avenue, Ashland University, Ashland, Ohio 44805, USA
    Toxicol Sci 58:144-52. 2000
    ..Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism...
  73. ncbi Liquid chromatographic determination of total and beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in lathyrus sativus seeds using both refractive index and bioelectrochemical detection
    Y Yigzaw
    Department of Analytical Chemistry, University of Lund, Sweden
    J Chromatogr A 929:13-21. 2001
    ..Ten grass pea samples have been collected from Lathyrism prone areas of Ethiopia to test the applicability of the presently developed analytical system for real sample ..
  74. ncbi [The broad bean's syndrome in ancient Egypt]
    D Lippi
    Cattedra di Storia della Medicina, Universita degli Studi di Bologna
    Med Secoli 1:301-6. 1989
    The problem of broad bean's syndrome and lathyrism in ancient Greece has been deeply studied, with particular referrement to the hypothetic medica and mystical reasons of the Pythagoric order not to eat broad beans...
  75. ncbi Pattern and associated factors of the neurolathyrism epidemic in Ethiopia
    Haileyesus Getahun
    South Gonder Health Department, Debre Tabor, Ethiopia
    Trop Med Int Health 7:118-24. 2002
    ..To describe the neurolathyrism epidemic in Ethiopia and to identify associated household factors...
  76. ncbi Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanine
    Vijayalakshmi Ravindranath
    National Brain Research Centre, SCO 5, 6 and 7, Sector 15, Part II, Gurgaon, Haryana 122001, India
    Neurochem Int 40:505-9. 2002
    ..A common mechanism involving oxidation of protein thiol groups may underlie neurodegeneration occurring through mitochondrial dysfunction induced by excitatory amino acid...
  77. ncbi Neurolathyrism in Ethiopia: assessment and comparison of knowledge and attitude of health workers and rural inhabitants
    Haileyesus Getahun
    South Gonder Health Department, Debre, Tabor, Ethiopia
    Soc Sci Med 54:1513-24. 2002
    ..The poor knowledge among health workers and the community and the general neglect of neurolathyrism requires urgent intervention. Appropriate strategies for the dissemination of information education, and communication (IEC) are needed...
  78. ncbi Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism
    Douglas A Dawson
    Department of Biology Toxicology, Ashland University, Ashland, OH 44805, USA
    Toxicology 177:267-84. 2002
    ..While betaAPN also has the potential to react with the cofactor, the nature of the reactivity observed suggests that betaAPN-cofactor binding is, at best, a secondary mechanism for induction of osteolathyrism in vivo...
  79. ncbi ABO blood groups, grass pea preparation, and neurolathyrism in Ethiopia
    Haileyesus Getahun
    South Gonder Health Department, Ethiopia
    Trans R Soc Trop Med Hyg 96:700-3. 2002
    ..40, 95% confidence interval 0.1-2.0). Blood group O remained significantly associated with the disease after adjusting for age, type of grass pea preparation consumed, and duration of consumption (AOR = 2.90)...
  80. ncbi Lathyrism: aqueous leaching reduces grass-pea neurotoxicity
    Peter S Spencer
    Third World Medical Research Foundation, Portland, Oregon, USA
    Lancet 362:1775-6. 2003
  81. ncbi Expression of extracellular matrix genes: transforming growth factor (TGF)-beta1 and ras in tibial fracture healing of lathyritic rats
    E C Ekholm
    Department of Medical Biochemistry and MediCity Research Laboratory, University of Turku, Turku, Finland
    Bone 27:551-7. 2000
    ..Both transforming growth factor (TGF)-beta1 and c-Ha-ras, which control cell growth and differentiation, were upregulated during the cartilaginous stage. The maximal expression of TGF-beta1 preceded that of ras in osteolathyrism...
  82. ncbi Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh
    A Haque
    Institute for Post Graduate Medical Research, Shahbagh, Dhaka, Bangladesh
    Nat Toxins 5:43-6. 1997
    ....
  83. ncbi Comparative evaluation of the combined osteolathyritic effects of two nitrile combinations on xenopus embryos
    D A Dawson
    Department of Biology Toxicology, Ashland University, 401 College Avenue, Ashland, OH 44805, USA
    Toxicology 147:193-207. 2000
    ..The results are consistent with the idea that beta APN and AAN induce osteolathyrism, at least in part, by different mechanisms...
  84. ncbi Food toxins, ampa receptors, and motor neuron diseases
    P S Spencer
    Department of Neurology, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Drug Metab Rev 31:561-87. 1999
    ..b>Lathyrism, a disease caused by dietary dependence on grass pea (Lathyrus sativus), is mediated by a stereospecific plant ..
  85. ncbi Combined osteolathyric effects of beta-aminopropionitrile and penicillamine on Xenopus embryos: statistical comparison with dose-addition and independence
    R K Mentzer
    Department of Biology Toxicology, Ashland University, OH 44805, USA
    Drug Chem Toxicol 22:359-74. 1999
    ..Response curve analyses indicated, in general, a combined effect between that expected for dose-addition and that for independence, which is a combined effect typical of chemicals acting dissimilarly...
  86. ncbi [Effect of benzquercin on the connective tissue of lathyritic mice. Optic and electron microscopic study]
    G Azzi
    Laboratoire de Biologie Cellulaire, Universite Paris VII, Faculte des Sciences, Paris, France
    Pathol Biol (Paris) 43:448-60. 1995
    ..As experimental model we used lathyrism induced in mice by chronic administration of beta-amino-propionitril (beta-APN)...
  87. ncbi Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity
    Latha Diwakar
    Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar 122050, India
    Neurochem Int 51:37-46. 2007
    ..Therapeutic interventions designed to upregulate glutaredoxin may offer neuroprotection against excitotoxicity in motor neurons...
  88. ncbi Studies on neurolathyrism
    K Jahan
    Institute of Nutrition and Food Science, University of Dhaka, Bangladesh
    Environ Res 60:259-66. 1993
    ..Autoclaving the seeds of LS with lime removes the toxin...
  89. ncbi Nitrogen-dioxide-induced emphysema in rats. Lack of worsening by beta-aminopropionitrile treatment
    J Blank
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia
    Am Rev Respir Dis 137:376-9. 1988
    ..These findings are in marked contrast to those observed with the exogenous elastase model of the disease, and they suggest that elastin synthesis and repair may not modulate elastin destruction in the NO2 model of emphysema...
  90. ncbi H reflex studies in neurolathyrism
    U K Misra
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Electroencephalogr Clin Neurophysiol 93:281-5. 1994
    Sixteen patients with lathyrism, age ranging between 18 and 55 years and duration of illness between 2 and 25 years, underwent H reflex studies with the aim of studying motor neurone excitability...
  91. ncbi Lathyrism in laying hens and increases in egg weight
    S D Chowdhury
    Division of Biochemistry and Physiology, Wye College, University of London, Ashford, Kent
    Vet Rec 123:272-5. 1988
    The cause of the increased egg weight in hens with lathyrism was investigated by feeding laying birds with diets containing beta-aminopropionitrile, the toxic principle of certain legume seeds in the genus Lathyrus...
  92. ncbi Guam ALS/parkinsonism-dementia: a long-latency neurotoxic disorder caused by "slow toxin(s)" in food?
    P S Spencer
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, N Y 10461
    Can J Neurol Sci 14:347-57. 1987
    ..Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity...
  93. ncbi The effects of lathyrogens on intestinal anastomoses in the rat
    K van Doorn
    Department of General Surgery, St Radboud University Hospital, Nijmegen, The Netherlands
    Exp Mol Pathol 52:37-45. 1990
    ....
  94. doi The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids
    E Arthur Bell
    Henriette Raphael Building, School of Biomedical Sciences, Guy s Campus, King s College London, London, UK
    Amyotroph Lateral Scler 10:21-5. 2009
    Because of the similarity of ALS/PDC symptoms to those of the paralytic disease lathyrism, cycad seeds from Guam were analyzed for the presence of the non-protein amino acid b-ODAP, which is known to cause lathyrism...
  95. ncbi Epidemiological study of lathyrism in northwestern districts of Bangladesh
    A Haque
    Institute of Postgraduate Medicine and Research, Department of Neurology, Dacca, Bangladesh
    Neuroepidemiology 15:83-91. 1996
    ..of Bangladesh with a population of 629,752 were surveyed from June 1991 to March 1993 to detect and follow up lathyrism patients...
  96. ncbi Lathyrism and the half-life of collagen
    A A Taverne
    University of Queensland Dental School, Brisbane
    Aust Orthod J 12:110-5. 1991
    ..Experiments were performed, using Wistar rats, which looked into the relationship between collagen turnover and lathyrism. The collagen turnover was established in teeth not erupting after the administration of lathyrogens...

Research Grants17

  1. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..g. the Guam amyotrophic lateral sclerosis, konzo, and/or lathyrism) suggests that environmental factors e.g. exposure to certain neurotoxins cause the motor system to degenerate...
  2. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..g. the Guam amyotrophic lateral sclerosis, konzo, and/or lathyrism) suggests that environmental factors e.g. exposure to certain neurotoxins cause the motor system to degenerate...
  3. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL TSHALA KATUMBAY; Fiscal Year: 2009
    ..g. the Guam amyotrophic lateral sclerosis, konzo, and/or lathyrism) suggests that environmental factors e.g. exposure to certain neurotoxins cause the motor system to degenerate...
  4. PLANT TOXINS AND DEMENTIA IN THE WESTERN PACIFIC
    TOM MABRY; Fiscal Year: 1992
    b>Lathyrism, a motorneurone disease of India and Africa, is caused by beta-oxalylaminoalanine (L-BOAA) which is present in the seeds of the legume Lathyrus sativus. The seeds of this plant are ground to a flour and used as food...
  5. TOXIC PROBES OF NEURODEGENERATIVE DISEASES
    Peter Spencer; Fiscal Year: 1991
    ..mechanisms underlying self-limiting and progressive neurogenerative disease models, acrylamide neuropathy, Lathyrism (beta-N-oxalylamino-L-alanine), Amnestic Shellfish Poisoning (domoic acid) and, notably, the cycad-linked and ..
  6. CHRONIC NEUROTOXICITY OF BMAA AND NON NMDA AGONISTS
    John Weiss; Fiscal Year: 1990
    ..We have found that low concentrations of BMAA (like BOAA, which causes lathyrism) may be able to produce selective neuronal injury through the activation of non-NMDA receptors and are therefore ..
  7. (NEURO)TOXICOGENOMICS AND CHILD HEALTH
    Peter Spencer; Fiscal Year: 2005
    ..abstract_text> ..
  8. NEUROTOXIC SUPERFUND CHEMICALS AND BIOMAKERS
    Peter Spencer; Fiscal Year: 2007
    ..abstract_text> ..
  9. Mixture Toxicity - Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2008
    ..Environmental releases of these chemicals are possible, which could also affect public health. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Mixture Toxicity: Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2003
    ..Upon completion, the project should provide an answer as to whether there is a relationship between the type of combined effect obtained and the molecular site(s) of action of the agents. ..
  11. (NEURO)TOXICOGENOMICS AND CHILD HEALTH
    Peter Spencer; Fiscal Year: 2006
    ..abstract_text> ..