Genomes and Genes
Summary: A paralytic condition of the legs caused by ingestion of lathyrogens, especially beta-aminopropionitrile, found in the seeds of plants of the genus Lathyrus (see FABACEAE).
- Prevention of neurolathyrism during droughtS L N Rao
Lancet 363:657. 2004
- New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in north west BangladeshA Haque
Department of Neurology, Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh
Paraplegia 32:193-5. 1994..Sporadic occurrence of HTLV-1 infection (0.9%) and of osteolathyrism was found among the neurolathyrism patients. Osteolathyrism is linked to the consumption of the green shoots of Lathyrus sativus...
- A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass peaS L N Rao
Department of Biochemistry, Osmania University, Hyderabad, India
Food Chem Toxicol 49:620-2. 2011..These novel approaches to both ODAP and homoarginine might entirely change our perception of this poor man's pulse...
- The nutritive value of grasspea (Lathyrus sativus) and allied species, their toxicity to animals and the role of malnutrition in neurolathyrismDirk Enneking
Department of Education and Children s Services, Kangaroo Inn Area School, South Australia, Australia
Food Chem Toxicol 49:694-709. 2011..Interruptions to these processes and excessive concurrent demands for reduced sulfur amino acids are likely to be conducive to the onset of neurotoxicity...
- Brain glutathione as a target for aetiological factors in neurolathyrism and konzoPeter B Nunn
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Food Chem Toxicol 49:662-7. 2011....
- A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agentsJordi Llorens
Departament de Ciències Fisiològiques II, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
Food Chem Toxicol 49:563-70. 2011Konzo and lathyrism are associated with consumption of cassava and grass pea, respectively. Cassava consumption has also been associated with a third disease, tropical ataxic neuropathy (TAN)...
- BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacingS Lees
Bioengineering Department, Forsyth Dental Center, Boston, MA 02115
Connect Tissue Res 24:95-105. 1990..Much of the effects on bone properties occur at the higher BAPN dosages where overt osteolathyrism is observed and where there seem to be only small changes in crosslinking density...
- The role of ascorbic acid on collagen structure and levels of serum interleukin-6 and tumour necrosis factor-alpha in experimental lathyrismN Senturk
Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Clin Exp Dermatol 29:168-75. 2004b>Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme essential for interfibrillar cross-linking...
- Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famineHaileyesus Getahun
South Gonder Health Department, Debre Tabor, Amhara Regional State, Ethiopia Ghent University, Ghent, Belgium
Lancet 362:1808-10. 2003..During famine, cereals and nutritional information should reach people before they have grass pea as the only food...
- Prevention of neurolathyrism during droughtFernand Lambein
Lancet 363:657. 2004
- Periodontal & systemic bone changes in rats with experimental lathyrismGonca Keles
Ondokuzmayis University, Faculty of Dentistry, Department of Periodontology, Samsun, Istanbul, Turkey
Indian J Med Res 123:541-6. 2006It is not clear how lathyrism affects the systemic bone metabolism...
- Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrismM P Pratap Rudra
Department of Biochemistry, Osmania University, Hyderabad 500007, India
Clin Biochem 37:318-22. 2004..sativus...
- A life-saving food plant producing more neurotoxin under environmental stressAsnake Fikre
Institute Plant Biotechnology for Developing Countries, Ghent University, Belgium
Commun Agric Appl Biol Sci 71:79-82. 2006
- Osteolathyrism in the rat: an X-ray diffraction study of collagen from normal and lathyritic rats. 1964Harold L Kundel
Acad Radiol 9:570-9. 2002
- The effects of beta-aminopropionitrile on colonic anastomosis in ratsTurker Bulut
Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Turkey
J Invest Surg 17:211-9. 2004..If collagen synthesis could be altered to minimize the contracture, then the outcome could be improved. Lathyrism produces poorly cross-linked collagen in healing anastomosis, keeping a larger portion of the synthesized ..
- Chapter 50: history of tropical neurologyAdesola Ogunniyi
Department of Medicine, University College Hospital, Ibadan, Nigeria
Handb Clin Neurol 95:815-30. 2010..The story moved from lathyrism through Jamaican neuropathy to cassava-induced epidemic neuropathy, which was contrasted with Konzo, also ..
- Production of diamino propionic acid ammonia lyase by a new strain of Salmonella typhimurium PU011K R Rupesh
Department of Biotechnology, Pondicherry University, Kalapet, Pondicherry 605014, India
BMC Microbiol 2:5. 2002..DAP is a neurotoxin, which, when consumed, causes a disease called Lathyrism. Lathryrism may manifest as Neurolathyrism or Osteolathyrism, in which the nervous system, and bone formation ..
- Chemical studies on the cyanogen bromide peptides of rat skin collagen. The covalent structure of alpha 1-CB5, the major hexose-containing cyanogen bromide peptide of alpha 1W T Butler
Biochemistry 9:44-50. 1970
- Isolation of tropoelastin a from lathyritic chick aortaeC B Rich
Biochem J 217:581-4. 1984..However, it differs from authentic tropoelastin b in containing a higher percentage of polar amino acids and cysteine residues. In addition, the amount of proline hydroxylation is 3 times higher than that found in chick tropoelastin b...
- Lathyrism, leg cramps, and thrombocytopenia: cascade of events starting in a concentration cAMPErica Sigler
Hematology Institute, Kaplan Medical Center, Rehovot, Israel
Am J Med 120:e3. 2007
- Knowledge and management of disabling conditions in South Asian histories: implications for leprosy futuresM Miles
Indian J Lepr 75:153-67. 2003..by reviewing the historical careers of four disabling conditions sharing some features with leprosy: lathyrism, iodine deficiency disorders (IDD), cataract and poliomyelitis...
- Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesisKimino Kawaguchi
Laboratory of Biochemistry, School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Chiba 274 8555, Japan
Biochem Biophys Res Commun 428:160-6. 2012..The present data shed light on the role and the mechanism of vascular insult in causing dysfunction and moribund motor neurons in experimental NL...
- The ratio 1660/1690 cm(-1) measured by infrared microspectroscopy is not specific of enzymatic collagen cross-links in bone tissueDelphine Farlay
INSERM, UMR 1033, Lyon, France
PLoS ONE 6:e28736. 2011....
- Portosystemic myelopathy: spastic paraparesis after portosystemic shuntingHarold O Conn
Yale University School of Medicine, New Haven, Connecticut, USA
Scand J Gastroenterol 41:619-25. 2006..b>Lathyrism, a toxic syndrome with similar symptoms and signs, is caused by the ingestion of a legume, Lathyrus sativa, ..
- Role of glutamate and nitric oxide in onset of motor neuron degeneration in neurolathyrismArjun L Khandare
Food and Drug Toxicology Research Center, National Institute of Nutrition, Hyderabad 500007, India
Neurotoxicology 34:269-74. 2013..This review brings together all the molecular events reported so far, emphasizing on the possible role of glutamate and nitric oxide mediated cell death...
- Neurolathyrism: two Ethiopian case reports and review of the literatureYohannes W Woldeamanuel
Department of Neurology, Addis Ababa University, Addis Ababa, Ethiopia
J Neurol 259:1263-8. 2012..Education, avoidance of the grasspea and measures to reduce toxin burden are possible methods...
- Metabolic and toxic myelopathiesNeeraj Kumar
Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Semin Neurol 32:123-36. 2012..or copper deficiency, disorders that have a geographical predilection and are due to a suspected toxin such as lathyrism, and disorders due to a possible toxin but without a geographical predilection such as hepatic myelopathy (Table ..
- Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010Delphin Diasolua Ngudi
Programme National de Nutrition, Kinshasa, Democratic Republic of the Congo
PLoS Negl Trop Dis 6:e1759. 2012..Konzo and neurolathyrism can be prevented by a balanced diet...
- Relevance of neuroimaging in the diagnosis and management of tropical neurologic disordersP Satishchandra
Department of Neurology, NIMHANS, Bangalore, Karnataka, India
Neuroimaging Clin N Am 21:737-56, vii. 2011..Infections are more common in the tropics and require special attention in view of their potential treatability...
- Potentiation of neurotoxicity of Lathyrus sativus by manganese: alterations in blood-brain barrier permeabilityGeeta Mishra
Food Toxicology Laboratory, Indian Institute of Toxicology Research, Council of Scientific Research, Mahatma Gandhi Marg, Lucknow, India
Toxicol Mech Methods 19:318-26. 2009..These results suggest that Mn may potentiate the neurotoxicity of lathyrus/ODAP by altering the BBB permeability...
- Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidantsHaileyesus Getahun
South Gondar Health Department, Debre Tabor, Ethiopia
Trop Med Int Health 10:169-78. 2005..To study an array of household individual and dietary risk factors for neurolathyrism...
- Towards the re-introduction of grass pea (Lathyrus sativus) in the West Balkan Countries: the case of Serbia and Srpska (Bosnia and Herzegovina)A Mikic
Institute of Field and Vegetable Crops, Novi Sad, Serbia
Food Chem Toxicol 49:650-4. 2011..Grass pea is commonly used boiled and along with other pulses, with no reports on lathyrism among the local people...
- Assessing diet in populations at risk for konzo and neurolathyrismDarna L Dufour
Department of Anthropology, University of Colorado, Boulder, Colorado 80309, USA
Food Chem Toxicol 49:655-61. 2011..objective of this paper is to discuss methods for assessing dietary intake in populations at risk for konzo and lathyrism. These methods include weighed food records and interview based techniques like 24-h recalls and food frequency ..
- Studies on neurolathyrism in Ethiopia: dietary habits, perception of risks and preventionA Fikre
Ethiopian Institute for Agricultural Research, Debre Zeit Center, PO Box 32, Debre Zeit, Ethiopia
Food Chem Toxicol 49:678-84. 2011..This observation points to the correlation between low neurolathyrism incidence and a better balanced diet as well as metallic kitchen utensils, suggesting a new approach for neurolathyrism prevention...
- Effect of methionine supplement on physical responses and neurological symptoms in broiler chicks fed grass pea (Lathyrus sativus)-based starter rationAsnake Fikre
Institute of Plant Biotechnology for Developing Countries IPBO, Ghent University, KL Ledeganckstraat 35, B 9000 Ghent, Belgium
Food Chem Toxicol 48:11-7. 2010..These results suggest that methionine can improve a grass pea-based diet for broiler chicks and especially can protect young chicks from neurological symptoms...
- [Describing neurolathyrism. Physicians and the lathyrism epidemic in post-civil war Spain]M I del Cura
Departamento de Ciencias de la Salud I, Universidad Rey Juan Carlos, Madrid, Espana
Rev Neurol 48:265-70. 2009b>Lathyrism is a chronic disease involving spastic paralysis of the lower limbs caused by the prolonged consumption of large amounts of flour made from grass pea, or almorta as it is known in Spain...
- Possible etiologies for tropical spastic paraparesis and human T lymphotropic virus I-associated myelopathyV Zaninovic'
Neurologia Clinica, Universidad del Valle, Cali, Colombia
Braz J Med Biol Res 37:1-12. 2004..Glutamate-mediated excitotoxicity, central distal axonopathies, cassava, lathyrism and cycad toxicity may explain most cases of TSP...
- A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legsK Kusama-Eguchi
Laboratory of Biology, Nihon University College of Pharmacy, Narashinodai, Funabashi, Japan
Amino Acids 28:139-43. 2005..032. These paralyzed rats displayed the severe atrophy of the ventral root of the lumbar cord as well as degenerations of motor neuron. The rats were useful models for the study of motor neuron degeneration in the spinal cord...
- Sulfur amino acids deficiency caused by grass pea diet plays an important role in the toxicity of L-β-ODAP by increasing the oxidative stress: studies on a motor neuron cell lineKuniko Kusama-Eguchi
Research Unit of Biochemistry, School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba 274 8555, Japan
Food Chem Toxicol 49:636-43. 2011....
- Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cordKuniko Kusama-Eguchi
Research Unit of Molecular Cell Biology, College of Pharmacy, Nihon University, Chiba 274 8555, Japan
J Comp Neurol 518:928-42. 2010..For the first time, we present a model of the early molecular events that occur during chemically induced spinal cord injury, which can potentially be applied to other neurodegenerative disorders...
- Ultrastructural and histomorphometric alterations of rat jaw bones after experimental induction of lathyrismDalia H El Rouby
Oral Pathology Department, Faculty of Oral and Dental Medicine, Cairo University, Egypt
Arch Oral Biol 53:916-23. 2008..The aim of this study was to investigate the effect of beta-aminopropionitrile (beta-APN), present in Lathyrus sativus (L. sativus) seeds consumed in drought prone areas, on the maxillary and mandibular bones of rats...
- 50 years ago in CORR : skeletal lesions produced by aminonitriles by Ignacio V. Ponseti MD CORR 1957;9:131-144Ignacio V Ponseti
Clin Orthop Relat Res 466:255-6. 2008
- Reduced reciprocal inhibition is seen only in spastic limbs in patients with neurolathyrismC Crone
Department of Clinical Neurophysiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
Exp Brain Res 181:193-7. 2007..These findings are consistent with the hypothesis that reduced reciprocal inhibition plays a causal role in the pathophysiology of spasticity...
- Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanismsC J Jiao
Key Laboratory of Arid Agroecology under the Ministry of Education Institute of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
Food Chem Toxicol 49:543-9. 2011..was considered responsible for human lathyrism. The levels of β-ODAP were reported to vary in different tissues during plant development, and to be affected ..
- Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from EthiopiaYu Haey Kuo
Laboratory of Physiological Chemistry, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
Clin Biochem 40:397-402. 2007..The irreversibly crippling disease neurolathyrism is caused by prolonged over-consumption of Lathyrus sativus seed. The molecular mechanism of toxicity is unclear and more biochemical information is needed...
- The effect of lathyrism on dentin structure of the rat incisors: a morphometric and scanning electron microscopic investigationDalia Hussein El Rouby
Oral Pathology Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
J Oral Pathol Med 39:424-30. 2010..The present study was designed to study the effect of beta-aminopropionitrile (beta-APN), present in Lathyrus sativus grass pea consumed in drought prone areas, on dentin of the continuously erupting rat incisors...
- In search of a new therapeutic target for the treatment of genetically triggered thoracic aortic aneurysms and cardiovascular conditions: insights from human and animal lathyrismHisham M F Sherif
Department of Cardiac Surgery, Christiana Hospital, Christiana Care Health System, 4755 Ogletown Stanton Road, Suite 1E50, Newark, DE 19718, USA
Interact Cardiovasc Thorac Surg 11:271-6. 2010b>Lathyrism, or the effect of certain plants on connective tissue disruption, particularly involving the vascular and skeletal systems, especially aortic dissection/rupture, has been well documented in animals...
- Genetic improvement of grass pea for low neurotoxin (β-ODAP) contentShiv Kumar
Biodiversity and Integrated Gene Management Program, International Center for Agricultural Research in the Dry Areas, PO Box 5466, Aleppo, Syria
Food Chem Toxicol 49:589-600. 2011..low ODAP varieties, which along with improved agronomic and detoxification practices can help reduce the risk of lathyrism. Collaborative efforts between ICARDA and NARS have resulted in development of improved varieties such as Wasie ..
- Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytesLorraine Brennan
UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Neurochem Int 48:739-45. 2006..Collectively these results show that the gliotoxin, L-serine-O-sulphate, causes major disruptions to metabolic pathways in primary cultures of astrocytes...
- Determination of systemically & locally induced periodontal defects in ratsGonca Gonca Cayir Keles
Ondokuzmayis University, Faculty of Dentistry, Department of Periodontology, Samsun, Istanbul, Turkey
Indian J Med Res 121:176-84. 2005..on bone metabolism is unclear, therefore we undertook this study to observe periodontal and systemic alterations in experimental lathyrism in rat and compare these changes to that observed in the locally induced periodontitis group.
- Alteration of elastic architecture in the lathyritic rat aorta implies the pathogenesis of aortic dissecting aneurysmY Nakashima
First Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Am J Pathol 140:959-69. 1992..These results suggest that the alteration of the elastic architecture causes an unstable connection between each elastic lamina, and is related to the initiation and the progression of dissecting aneurysm...
- Peripheral and central conduction studies in neurolathyrismU K Misra
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
J Neurol Neurosurg Psychiatry 57:572-7. 1994To study the involvement of motor and sensory pathways in neurolathyrism, 19 patients with lathyrism from Unnao, India, where lathyrism is endemic, were studied. The mean age of the patients at the time of the onset of illness was 35...
- Studies of the etiology and pathogenesis of motor neuron diseases. III. Magnetic cortical stimulation in patients with lathyrismJ Hugon
Department of Neurology, Limoges University Hospital, France
Acta Neurol Scand 88:412-6. 1993..of central motor pathways were conducted of 11 Spanish subjects with varying degrees of spastic paraparesis (lathyrism)...
- From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrismF Lambein
Laboratory of Physiological Chemistry, Faculty of Medicine, University of Gent, Belgium
Toxicon 32:461-6. 1994..zinc and with high iron content (Ethiopian vertisols), may be responsible for higher incidence of human lathyrism, one of the oldest neurotoxic diseases known to man...
- Emphysema-like changes in the lungs of the blotchy mouseD E Fisk
Am Rev Respir Dis 113:787-97. 1976..The Blotchy strain may be a useful model in which to investigate how abnormalities of connective tissue proteins influence pulmonary structure and function...
- In vitro toxicological investigations of isoxazolinone amino acids of Lathyrus sativusM Riepe
Center for Research on Environmental and Occupational Toxicology, Oregon Health Sciences University, Portland 97201 3098, USA
Nat Toxins 3:58-64. 1995..These results suggest that Lathyrus sativus plants engineered to block the synthesis of beta-ODAP may accumulate a neurotoxic precursor and therefore must be tested for the presence of both BIA and beta-ODAP...
- The covalent structure of collagen: amino acid sequence of the N-terminal region of alpha2-CB3 from rat skin collagen and alpha2-CB3.5 from calf skin collagenP P Fietzek
Hoppe Seylers Z Physiol Chem 355:647-50. 1974
- Experimental lathyrism: exostoses and aneurysmal-like bone cysts of the mandible in the ratE Baden
College of Dental Medicine, Fairleigh Dickinson University, Hackensack, NJ
Ann Pathol 7:297-303. 1987The effect of chronic lathyrism on the mandible of the rat was studied...
- Studies on the etiology and pathogenesis of motor neuron diseases. II. Clinical and electrophysiologic features of pyramidal dysfunction in macaques fed Lathyrus sativus and IDPNJ Hugon
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
Neurology 38:435-42. 1988A primate model of lathyrism has been produced in well-nourished male cynomolgus monkeys chronically fed a fortified diet composed of Lathyrus sativus (chickling or grass pea) and given daily per os an alcoholic extract of this legume...
- Prevalence of paralytic poliomyelitis in rural and urban populations in Ethiopia: report of a house-to-house surveyM Maru
Gondar College of Medical Sciences, Gondar Regional Health Department, Ethiopia
Am J Trop Med Hyg 38:633-5. 1988..Nineteen percent needed a stick support for walking while 12% were unable to walk even with support. This problem was more common in rural populations. The prevalence of paralytic poliomyelitis was 7.3/1,000 children 5-9 years old...
- Bronchial asthma caused by Lathyrus sativus flourR Valdivieso
Servico de Alergia, Hospital Ramon y Cajal, Madrid, Spain
Allergy 43:536-9. 1988..Specific IgE antibodies to Lathyrus sativus flour was demonstrated by indirect enzyme immunoassay. We suggest that our patient's allergic symptoms were due to the development of Type I allergic reactivity to L. sativus antigens...
- Anti-nutritional and toxic factors in food legumes: a reviewY P Gupta
Division of Agricultural Biochemistry, Indian Agricultural Research Institute, New Delhi
Plant Foods Hum Nutr 37:201-28. 1987..These factors are shown to be widely present in leguminous foods which are important constituents of the diet of a large section of the world's population, and particularly, of people in the developing countries...
- The role of collagen crosslinking in the increased stiffness of avian dystrophic muscleH Feit
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202
Muscle Nerve 12:486-92. 1989..In separate experiments, lathyrism was induced by treating normal (412/412) and dystrophic (413/413) chickens with alpha-acetoaminonitrile, an ..
- Comparison of the effects of two lathyrogens on the reproductive system of the laying henS D Chowdhury
Department of Poultry Science, Bangladesh Agricultural University, Mymensingh
Vet Rec 124:240-2. 1989..The reduced egg production after feeding beta-aminopropionitrile was due to the reduced growth rate of the ovary, and in the case of semicarbazide, to the atresia of large yolky follicles...
- Effect of lathyrogen on collagen of methylcholanthrene-induced sarcoma of ratE Bankowski
Department of Biochemistry, Medical Academy of Białystok, Poland
Zentralbl Allg Pathol 136:247-53. 1990..Although lathyrogen had no significant effect on the growth and overall size of fibrosarcoma, histological studies confirmed that changes had occurred to appearance and distribution of collagenous components of extracellular matrix...
- Electrophysiologic features in patients with chronic neurolathyrismV E Drory
Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
Acta Neurol Scand 85:401-3. 1992..Two of them (25%) showed electrophysiological signs of lower motor neuron disease in their lower limbs. Subclinical affection of the anterior horn cells occurs probably more frequently than expected in chronic neurolathyrism...
- Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorderR T Haimanot
Faculty of Medicine, Addis Ababa University, Ethiopia
Int J Epidemiol 19:664-72. 1990b>Lathyrism is a disorder of the central motor system, induced by heavy consumption of the grass-pea, Lathyrus sativus an environmentally tolerant legume containing the neurotoxic excitatory amino acid beta-N-oxalylamino-L-alanine (BOAA)...
- Reliability of eruption rate measurements of the rat incisorA A Taverne
University of Queensland Dental School, Brisbane
Aust Orthod J 12:33-6. 1991..It furthermore provides an excellent method to assess the lathyrogenic condition of these animals...
- Effects of lathyritic drugs and lathyritic demineralized bone matrix on induced and sustained osteogenesisP E Di Cesare
Cartilage and Bone Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003
J Orthop Res 12:395-402. 1994..These results indicate that the degree of crosslinking of the collagen matrix that acts as a carrier for osteoinductive proteins plays a key role in inducing and sustaining osteogenesis...
- Collagen responsible for tooth eruption? A study of the eruption of rat incisorsA A Taverne
Division of Orthodontics, Pediatric Dentistry and Community Dentistry, Department of Dentistry, University of Qld Dental School, Brisbane, Australia
Aust Orthod J 12:199-206. 1993..As the collagen protein seems to play a key role in tooth eruption, the investigation concentrated on the presence and maturation of collagen and its possible function in the process of tooth eruption...
- The epidemiology of lathyrism in north and central EthiopiaR T Haimanot
Faculty of Medicine, Addis Abeba University, Ethiopia
Ethiop Med J 31:15-24. 1993b>Lathyrism is a neurotoxic disorder caused by excessive, prolonged consumption of the hardy, environmentally tolerant legume, the grass-pea, Lathyrus sativus, which contains the neurotoxic amino acid beta-N-oxalylamino-L-alanine acid (..
- Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus developmentM A Cotter
Department of Biology Toxicology, 401 College Avenue, Ashland University, Ashland, Ohio 44805, USA
Toxicol Sci 58:144-52. 2000..Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism...
- Liquid chromatographic determination of total and beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in lathyrus sativus seeds using both refractive index and bioelectrochemical detectionY Yigzaw
Department of Analytical Chemistry, University of Lund, Sweden
J Chromatogr A 929:13-21. 2001..Ten grass pea samples have been collected from Lathyrism prone areas of Ethiopia to test the applicability of the presently developed analytical system for real sample ..
- [The broad bean's syndrome in ancient Egypt]D Lippi
Cattedra di Storia della Medicina, Universita degli Studi di Bologna
Med Secoli 1:301-6. 1989The problem of broad bean's syndrome and lathyrism in ancient Greece has been deeply studied, with particular referrement to the hypothetic medica and mystical reasons of the Pythagoric order not to eat broad beans...
- Pattern and associated factors of the neurolathyrism epidemic in EthiopiaHaileyesus Getahun
South Gonder Health Department, Debre Tabor, Ethiopia
Trop Med Int Health 7:118-24. 2002..To describe the neurolathyrism epidemic in Ethiopia and to identify associated household factors...
- Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanineVijayalakshmi Ravindranath
National Brain Research Centre, SCO 5, 6 and 7, Sector 15, Part II, Gurgaon, Haryana 122001, India
Neurochem Int 40:505-9. 2002..A common mechanism involving oxidation of protein thiol groups may underlie neurodegeneration occurring through mitochondrial dysfunction induced by excitatory amino acid...
- Neurolathyrism in Ethiopia: assessment and comparison of knowledge and attitude of health workers and rural inhabitantsHaileyesus Getahun
South Gonder Health Department, Debre, Tabor, Ethiopia
Soc Sci Med 54:1513-24. 2002..The poor knowledge among health workers and the community and the general neglect of neurolathyrism requires urgent intervention. Appropriate strategies for the dissemination of information education, and communication (IEC) are needed...
- Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrismDouglas A Dawson
Department of Biology Toxicology, Ashland University, Ashland, OH 44805, USA
Toxicology 177:267-84. 2002..While betaAPN also has the potential to react with the cofactor, the nature of the reactivity observed suggests that betaAPN-cofactor binding is, at best, a secondary mechanism for induction of osteolathyrism in vivo...
- ABO blood groups, grass pea preparation, and neurolathyrism in EthiopiaHaileyesus Getahun
South Gonder Health Department, Ethiopia
Trans R Soc Trop Med Hyg 96:700-3. 2002..40, 95% confidence interval 0.1-2.0). Blood group O remained significantly associated with the disease after adjusting for age, type of grass pea preparation consumed, and duration of consumption (AOR = 2.90)...
- Lathyrism: aqueous leaching reduces grass-pea neurotoxicityPeter S Spencer
Third World Medical Research Foundation, Portland, Oregon, USA
Lancet 362:1775-6. 2003
- Expression of extracellular matrix genes: transforming growth factor (TGF)-beta1 and ras in tibial fracture healing of lathyritic ratsE C Ekholm
Department of Medical Biochemistry and MediCity Research Laboratory, University of Turku, Turku, Finland
Bone 27:551-7. 2000..Both transforming growth factor (TGF)-beta1 and c-Ha-ras, which control cell growth and differentiation, were upregulated during the cartilaginous stage. The maximal expression of TGF-beta1 preceded that of ras in osteolathyrism...
- Evidence of osteolathyrism among patients suffering from neurolathyrism in BangladeshA Haque
Institute for Post Graduate Medical Research, Shahbagh, Dhaka, Bangladesh
Nat Toxins 5:43-6. 1997....
- Comparative evaluation of the combined osteolathyritic effects of two nitrile combinations on xenopus embryosD A Dawson
Department of Biology Toxicology, Ashland University, 401 College Avenue, Ashland, OH 44805, USA
Toxicology 147:193-207. 2000..The results are consistent with the idea that beta APN and AAN induce osteolathyrism, at least in part, by different mechanisms...
- Food toxins, ampa receptors, and motor neuron diseasesP S Spencer
Department of Neurology, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
Drug Metab Rev 31:561-87. 1999..b>Lathyrism, a disease caused by dietary dependence on grass pea (Lathyrus sativus), is mediated by a stereospecific plant ..
- Combined osteolathyric effects of beta-aminopropionitrile and penicillamine on Xenopus embryos: statistical comparison with dose-addition and independenceR K Mentzer
Department of Biology Toxicology, Ashland University, OH 44805, USA
Drug Chem Toxicol 22:359-74. 1999..Response curve analyses indicated, in general, a combined effect between that expected for dose-addition and that for independence, which is a combined effect typical of chemicals acting dissimilarly...
- [Effect of benzquercin on the connective tissue of lathyritic mice. Optic and electron microscopic study]G Azzi
Laboratoire de Biologie Cellulaire, Universite Paris VII, Faculte des Sciences, Paris, France
Pathol Biol (Paris) 43:448-60. 1995..As experimental model we used lathyrism induced in mice by chronic administration of beta-amino-propionitril (beta-APN)...
- Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicityLatha Diwakar
Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar 122050, India
Neurochem Int 51:37-46. 2007..Therapeutic interventions designed to upregulate glutaredoxin may offer neuroprotection against excitotoxicity in motor neurons...
- Studies on neurolathyrismK Jahan
Institute of Nutrition and Food Science, University of Dhaka, Bangladesh
Environ Res 60:259-66. 1993..Autoclaving the seeds of LS with lime removes the toxin...
- Nitrogen-dioxide-induced emphysema in rats. Lack of worsening by beta-aminopropionitrile treatmentJ Blank
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia
Am Rev Respir Dis 137:376-9. 1988..These findings are in marked contrast to those observed with the exogenous elastase model of the disease, and they suggest that elastin synthesis and repair may not modulate elastin destruction in the NO2 model of emphysema...
- H reflex studies in neurolathyrismU K Misra
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Electroencephalogr Clin Neurophysiol 93:281-5. 1994Sixteen patients with lathyrism, age ranging between 18 and 55 years and duration of illness between 2 and 25 years, underwent H reflex studies with the aim of studying motor neurone excitability...
- Lathyrism in laying hens and increases in egg weightS D Chowdhury
Division of Biochemistry and Physiology, Wye College, University of London, Ashford, Kent
Vet Rec 123:272-5. 1988The cause of the increased egg weight in hens with lathyrism was investigated by feeding laying birds with diets containing beta-aminopropionitrile, the toxic principle of certain legume seeds in the genus Lathyrus...
- Guam ALS/parkinsonism-dementia: a long-latency neurotoxic disorder caused by "slow toxin(s)" in food?P S Spencer
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, N Y 10461
Can J Neurol Sci 14:347-57. 1987..Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity...
- The effects of lathyrogens on intestinal anastomoses in the ratK van Doorn
Department of General Surgery, St Radboud University Hospital, Nijmegen, The Netherlands
Exp Mol Pathol 52:37-45. 1990....
- The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acidsE Arthur Bell
Henriette Raphael Building, School of Biomedical Sciences, Guy s Campus, King s College London, London, UK
Amyotroph Lateral Scler 10:21-5. 2009Because of the similarity of ALS/PDC symptoms to those of the paralytic disease lathyrism, cycad seeds from Guam were analyzed for the presence of the non-protein amino acid b-ODAP, which is known to cause lathyrism...
- Epidemiological study of lathyrism in northwestern districts of BangladeshA Haque
Institute of Postgraduate Medicine and Research, Department of Neurology, Dacca, Bangladesh
Neuroepidemiology 15:83-91. 1996..of Bangladesh with a population of 629,752 were surveyed from June 1991 to March 1993 to detect and follow up lathyrism patients...
- Lathyrism and the half-life of collagenA A Taverne
University of Queensland Dental School, Brisbane
Aust Orthod J 12:110-5. 1991..Experiments were performed, using Wistar rats, which looked into the relationship between collagen turnover and lathyrism. The collagen turnover was established in teeth not erupting after the administration of lathyrogens...
- NEUROTOXIC SUPERFUND CHEMICALS AND BIOMAKERSPeter Spencer; Fiscal Year: 2007..abstract_text> ..
- Mixture Toxicity: Evaluation of an Improved MethodologyDOUGLAS DAWSON; Fiscal Year: 2003..Upon completion, the project should provide an answer as to whether there is a relationship between the type of combined effect obtained and the molecular site(s) of action of the agents. ..
- (NEURO)TOXICOGENOMICS AND CHILD HEALTHPeter Spencer; Fiscal Year: 2006..abstract_text> ..