ciguatera poisoning

Summary

Summary: Poisoning caused by ingestion of SEAFOOD containing microgram levels of CIGUATOXINS. The poisoning is characterized by gastrointestinal, neurological and cardiovascular disturbances.

Top Publications

  1. ncbi Chronic fatigue syndrome following a toxic exposure
    D Racciatti
    Department of Infectious Diseases, G D Annunzio University, Chieti Scalo, Italy
    Sci Total Environ 270:27-31. 2001
  2. ncbi A pilot study for the detection of acute ciguatera intoxication in human blood
    Jaime Matta
    Department of Pharmacology and Toxicology, Ponce School of Medicine, Puerto Rico 00732, USA
    J Toxicol Clin Toxicol 40:49-57. 2002
  3. ncbi Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings
    Michael James Holmes
    Tropical Marine Science Institute, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Clin Exp Pharmacol Physiol 29:829-36. 2002
  4. ncbi Ciguatera: Australian perspectives on a global problem
    Richard J Lewis
    Institute for Molecular Biosciences, The University of Queensland, QLD 4072, Australia
    Toxicon 48:799-809. 2006
  5. doi Features of ciguatera fish poisoning cases in Hong Kong 2004-2007
    Chun Kwan Wong
    Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Shek Kip Mei, Kowloon, Hong Kong, China
    Biomed Environ Sci 21:521-7. 2008
  6. doi Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies
    Patricia A Tester
    National Ocean Service, NOAA, Beaufort, NC 28516, USA
    Toxicon 56:698-710. 2010
  7. doi Ciguatera risk management in French Polynesia: the case study of Raivavae Island (Australes Archipelago)
    Mireille Chinain
    Laboratoire des Micro algues Toxiques, Institut Louis Malarde, BP 30, 98713 Papeete Tahiti, French Polynesia
    Toxicon 56:674-90. 2010
  8. pmc Critical issues in the development of health information systems in supporting environmental health: a case study of ciguatera
    Sarah Goater
    School of Population Health, University of Queensland, Herston, Queensland, Australia
    Environ Health Perspect 119:585-90. 2011
  9. ncbi Study of an outbreak of ciguatera fish poisoning in Hong Kong
    Chun Kwan Wong
    Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Shek Kip Mei, Kowloon, Hong Kong
    Toxicon 46:563-71. 2005
  10. doi Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture
    Mireille Chinain
    Laboratoire des Micro algues Toxiques, Institut Louis Malarde, Papeete Tahiti, French Polynesia
    Toxicon 56:739-50. 2010

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Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Chronic fatigue syndrome following a toxic exposure
    D Racciatti
    Department of Infectious Diseases, G D Annunzio University, Chieti Scalo, Italy
    Sci Total Environ 270:27-31. 2001
    ..of the illness implicates the exposure to chemical and/or food toxins as precipitating factors: ciguatera poisoning, sick building syndrome, Gulf War syndrome, exposure to organochlorine pesticides, etc...
  2. ncbi A pilot study for the detection of acute ciguatera intoxication in human blood
    Jaime Matta
    Department of Pharmacology and Toxicology, Ponce School of Medicine, Puerto Rico 00732, USA
    J Toxicol Clin Toxicol 40:49-57. 2002
    ..No laboratory method is available for clinical diagnosis of acute ciguatera poisoning. The objective of this pilot study was to ascertain the potential usefulness of a bioassay to detect ..
  3. ncbi Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings
    Michael James Holmes
    Tropical Marine Science Institute, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Clin Exp Pharmacol Physiol 29:829-36. 2002
    ..5. Paralytic shellfish poisoning and DSP are the major concern for local and regionally produced seafood. To the best of our knowledge, ciguatera poisoning in Singapore only originates from imported reef fish.
  4. ncbi Ciguatera: Australian perspectives on a global problem
    Richard J Lewis
    Institute for Molecular Biosciences, The University of Queensland, QLD 4072, Australia
    Toxicon 48:799-809. 2006
    ..This review examines progress in our understanding of ciguatera from an Australian perspective, especially the laboratory-based research into the problem that was initiated by the late "Bob" Endean at the University of Queensland...
  5. doi Features of ciguatera fish poisoning cases in Hong Kong 2004-2007
    Chun Kwan Wong
    Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Shek Kip Mei, Kowloon, Hong Kong, China
    Biomed Environ Sci 21:521-7. 2008
    ....
  6. doi Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies
    Patricia A Tester
    National Ocean Service, NOAA, Beaufort, NC 28516, USA
    Toxicon 56:698-710. 2010
    ..The highest CFP incidence rates were in the eastern Caribbean where water temperatures are warmest and least variable...
  7. doi Ciguatera risk management in French Polynesia: the case study of Raivavae Island (Australes Archipelago)
    Mireille Chinain
    Laboratoire des Micro algues Toxiques, Institut Louis Malarde, BP 30, 98713 Papeete Tahiti, French Polynesia
    Toxicon 56:674-90. 2010
    ..Community education resulted in self-regulating behaviour towards avoidance of high-risk fish species and fishing locations...
  8. pmc Critical issues in the development of health information systems in supporting environmental health: a case study of ciguatera
    Sarah Goater
    School of Population Health, University of Queensland, Herston, Queensland, Australia
    Environ Health Perspect 119:585-90. 2011
    ....
  9. ncbi Study of an outbreak of ciguatera fish poisoning in Hong Kong
    Chun Kwan Wong
    Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Shek Kip Mei, Kowloon, Hong Kong
    Toxicon 46:563-71. 2005
    ..Cigua-Check analysis of 20 flesh grains from seven CTX-positive fishes, previously confirmed as CTX-positive samples by mouse bioassay, showed that 50% of flesh grains were CTX contaminated...
  10. doi Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture
    Mireille Chinain
    Laboratoire des Micro algues Toxiques, Institut Louis Malarde, Papeete Tahiti, French Polynesia
    Toxicon 56:739-50. 2010
    ..polynesiensis strains suggests that the toxin profile is a stable characteristic in this species. G. polynesiensis clones also proved inherently more toxic than other Gambierdiscus species isolated from other geographical areas...
  11. doi Revisiting the association between sea surface temperature and the epidemiology of fish poisoning in the South Pacific: reassessing the link between ciguatera and climate change
    Lyndon E Llewellyn
    Australian Institute of Marine Science, Townsville MC, Queensland, Australia
    Toxicon 56:691-7. 2010
    ..Such a model would complicate projections of the effects of climate change upon ciguatera beyond that of a simple relationship where increased SST may cause more ciguatera...
  12. ncbi Prevalence of chronic symptoms of ciguatera disease in French Polynesian adults
    Marie Ludivine Chateau-Degat
    Public Health Research Unit, Laval University Medical Research Center, CHUL, CHUQ, Quebec, Canada
    Am J Trop Med Hyg 77:842-6. 2007
    ..001). Our findings suggest that several symptoms observed in the acute phase of the disease are still experienced 15 days after onset. This supports previous observations based on isolated case reports...
  13. doi Ciguatera: a public health perspective
    Robert W Dickey
    U S FDA Center for Food Safety and Applied Nutrition, Office of Food Safety, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA
    Toxicon 56:123-36. 2010
    ..10ppb C-CTX-1 equivalent toxicity in fish from the tropical Atlantic, Gulf of Mexico, Caribbean, and 0.01ppb P-CTX-1 equivalent toxicity in fish from Pacific regions...
  14. pmc Ciguatera fish poisoning: treatment, prevention and management
    Melissa A Friedman
    Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    Mar Drugs 6:456-79. 2008
    ..The article is intended to clarify treatment options, and provide information about management and prevention of CFP, for emergency room physicians, poison control information providers, other health care providers, and patients...
  15. doi Severe seafood poisoning in French Polynesia: a retrospective analysis of 129 medical files
    C Gatti
    Institut Louis Malarde, B P 30, Papeete, Tahiti 98713, French Polynesia
    Toxicon 51:746-53. 2008
    ..Even if it is premature to conclude any correlation between the intoxication and the appearance of GBS, it is interesting to note that in both pathologies, morphological disturbances of nerve fibres have been reported...
  16. ncbi Use of two detection methods to discriminate ciguatoxins from brevetoxins: application to great barracuda from Florida Keys
    M Yasmine Bottein Dechraoui
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, Charleston, SC 29412, USA
    Toxicon 46:261-70. 2005
    ..Among 40 barracudas analyzed, 60% contained ciguatoxin levels in their liver measurable by the N2A assay with the most toxic fish containing 2.1ppb C-CTX-1 equivalents...
  17. ncbi Ciguatera poisoning
    Kira C Achaibar
    Department of Clinical Neurosciences, Imperial College London, UK
    Pract Neurol 7:316-22. 2007
    ..The patient's symptoms and small fibre neuropathy improved over a period of 10 months...
  18. doi Use of monoclonal antibodies as an effective strategy for treatment of ciguatera poisoning
    Masayuki Inoue
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Toxicon 53:802-5. 2009
    ....
  19. ncbi Biomonitoring of ciguatoxin exposure in mice using blood collection cards
    M Yasmine Bottein Dechraoui
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, Coastal Research Branch, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Toxicon 46:243-51. 2005
    ....
  20. ncbi Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP
    V Monica Bricelj
    Institute for Marine Biosciences, National Research Council, Halifax, Nova Scotia B3H 3Z1, Canada
    Nature 434:763-7. 2005
    ..Furthermore, global expansion of PSP to previously unaffected coastal areas might result in long-term changes to communities and ecosystems...
  21. ncbi Neurotoxic marine poisoning
    Geoffrey K Isbister
    Tropical Toxicology Unit, Menzies School of Health Research, Charles Darwin University, NT, and Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, NSW, Australia
    Lancet Neurol 4:219-28. 2005
    ..Because there are no antidotes, supportive care, including mechanical ventilation in patients with severe paralysis, is the mainstay of treatment...
  22. ncbi Pathological effects on mice by gambierol, possibly one of the ciguatera toxins
    Emiko Ito
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8673, Japan
    Toxicon 42:733-40. 2003
    ..With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation...
  23. pmc Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels
    Eva Cuypers
    Laboratorium voor Toxicologie, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, bus 922, KULeuven B 3000, Belgium
    Toxicon 51:974-83. 2008
    ..Therefore, these results lead to a better understanding of gambierol and its possible role in CFP and they may also be useful in the development of more effective treatments...
  24. pmc Neurotoxins from marine dinoflagellates: a brief review
    Da Zhi Wang
    State Key Lab of Marine Environmental Science Environmental Science Research Center, Xiamen University, Xiamen 361005, P R China
    Mar Drugs 6:349-71. 2008
    ..This review summarizes the origin, structure and clinical symptoms of PSP, NSP, CFP, AZP, yessotoxin and palytoxin produced by marine dinoflagellates, as well as their molecular mechanisms of action on voltage-gated ion channels...
  25. ncbi Neurologic signs of ciguatera disease: evidence of their persistence
    M L Chateau-Degat
    Public Health Research Unit, Laval University Medical Research Center, Sainte Foy, Quebec, Canada
    Am J Trop Med Hyg 77:1170-5. 2007
    ..Our results support the existence of neurologic impairments of CD and suggest their persistence for at least two months after onset...
  26. ncbi Ciguatera risk assessment in two toxic sites of French Polynesia using the receptor-binding assay
    H T Darius
    Laboratoire des Microalgues Toxiques, Institut Louis Malarde, BP 30, Papeete Tahiti, French Polynesia, France
    Toxicon 50:612-26. 2007
    ..In general, our findings were congruent with epidemiological data and the knowledge of local people only for risky fish species...
  27. ncbi Neuropsychological study of ciguatera fish poisoning: a longitudinal case-control study
    Melissa A Friedman
    Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
    Arch Clin Neuropsychol 22:545-53. 2007
    ..The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP)...
  28. ncbi Temporal trends and epidemiological aspects of ciguatera in French Polynesia: a 10-year analysis
    Marie Ludivine Chateau-Degat
    Public Health Research Unit, Laval University Medical Research Center CHUQ, Quebec, Canada
    Trop Med Int Health 12:485-92. 2007
    The purpose of this study was to report the temporal trends of the incidence of ciguatera poisoning from 1992 to 2001 in French Polynesia.
  29. pmc Outbreak bias in illness reporting and case confirmation in ciguatera fish poisoning surveillance in south Florida
    Elizabeth M Begier
    Preventive Medicine Residency Program, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Public Health Rep 121:658-65. 2006
    ....
  30. ncbi Optimization of ciguatoxin extraction method from blood for Pacific ciguatoxin (P-CTX-1)
    Marie Yasmine Bottein Dechraoui
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, Charleston, SC 29412, USA
    Toxicon 49:100-5. 2007
    ..In conclusion, both Caribbean and Pacific ciguatoxins can be readily extracted from blood using this modified method; however, in the case of P-CTX-1 we find that fresh blood is optimal...
  31. doi Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassay
    Cara Empey Campora
    Department of Pathology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96822, USA
    J Clin Lab Anal 22:246-53. 2008
    ..We conclude that the ELISA produces reliable and accurate results that are consistent with those provided by the accepted NB assay and that the ELISA has potential for future applications in screening fish populations for CTX...
  32. pmc Ciguatera fish poisoning, Canary Islands
    José Luis Pérez-Arellano
    Emerg Infect Dis 11:1981-2. 2005
  33. ncbi Comparative analysis of purified Pacific and Caribbean ciguatoxin congeners and related marine toxins using a modified ELISA technique
    Cara E Campora
    Department of Cell and Molecular Biology, University of Hawaii Manoa, Honolulu, Hawaii, USA
    J Clin Lab Anal 20:121-5. 2006
    ..Thus, the monoclonal antibody to CTX is able to specifically detect various CTX congeners at levels comparable to those naturally occurring in ciguatoxic fish...
  34. ncbi Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding
    Ivannah Pottier
    Laboratoire de Microbiologie Alimentaire USC INRA, Universite de Caen, Esplanade de la Paix, Caen 14032, France
    Toxicon 42:663-72. 2003
    ..However, FAT active on VSSCs and < 900 Da were suspected to contribute to the overall toxicity...
  35. ncbi Practical total synthesis of ciguatoxin CTX3C by improved protective group strategy
    Masayuki Inoue
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Org Lett 4:4551-4. 2002
    ..Alteration of the protective group from benzyl ether to 2-naphthylmethyl (NAP) ether drastically increases the yield for final global deprotection and has provided a sufficient amount of sample for further biological studies...
  36. ncbi Ciguatera poisoning: a global issue with common management problems
    J Y Ting
    Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Eur J Emerg Med 8:295-300. 2001
    b>Ciguatera poisoning, a toxinological syndrome comprising an enigmatic mixture of gastrointestinal, neurocutaneous and constitutional symptoms, is a common food-borne illness related to contaminated fish consumption...
  37. ncbi Ciguatera fish poisoning: a double-blind randomized trial of mannitol therapy
    Hans Schnorf
    Neurology Clinic, University Hospital of Geneva, Switzerland
    Neurology 58:873-80. 2002
    b>Ciguatera poisoning (CP) is worldwide the most common fish-borne illness and one of the most common forms of nonbacterial food poisoning...
  38. ncbi Chronicity of neurological features in ciguatera fish poisoning
    T Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, China
    Hum Exp Toxicol 20:426-8. 2001
    ..g., chronic fatigue, relapse of symptoms after exposure to ciguateric fish or alcohol, and peripheral neuropathy) may also indicate a lengthy persistence of ciguatoxins in the body...
  39. ncbi Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies
    I Pottier
    Laboratoire de Microbiologie Alimentaire USC INRA, Universite de Caen, Esplanade de la Paix F 14032 Caen cedex, France
    Food Addit Contam 19:1034-42. 2002
    ..In conclusion, this study confirms the usefulness of LC-MS analysis to determine the ciguatoxins levels and the toxin profile in fish flesh hazardous to humans...
  40. ncbi Rabbitfish ("aras"): an unusual source of ciguatera poisoning
    Bianca Raikhlin-Eisenkraft
    Israel Poison Information Center, Rambam Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Isr Med Assoc J 4:28-30. 2002
    b>Ciguatera poisoning is the commonest fish-borne seafood intoxication. It is endemic to warm water tropical areas and is caused by consumption of bottom-dwelling shore reef fish, mostly during spring and summer...
  41. ncbi Ciguatera: recent advances but the risk remains
    L Lehane
    National Office of Animal and Plant Health, Agriculture, Fisheries and Forestry Australia, Canberra, ACT
    Int J Food Microbiol 61:91-125. 2000
    ..Only certain genetic strains produce ciguatoxins, and environmental triggers for increasing toxin production are unknown...
  42. ncbi Ciguatera update
    L Lehane
    National Office of Animal and Plant Health, Agriculture, Fisheries and Forestry Australia, Canberra, ACT
    Med J Aust 172:176-9. 2000
    ..The incidence of ciguatera is expected to increase in association with global warming and widespread bleaching and death of coral...
  43. ncbi Ciguatera fish poisoning in the Caribbean islands and Western Atlantic
    I Pottier
    Laboratoire de Microbiologie Alimentaire, Universite de Caen, Esplanade de la Paix, 14032 Caen Cedex, France
    Rev Environ Contam Toxicol 168:99-141. 2001
    ..A ciguatera management plan that integrates epidemiology, treatment, and a simple method of detection is required to ensure the protection of consumers...
  44. doi Development of an enzyme-linked immunosorbent assay for the detection of ciguatoxin in fish tissue using chicken immunoglobulin Y
    Cara Empey Campora
    Department of Pathology, John A Burns School of Medicine, Honolulu, Hawaii 96822, USA
    J Clin Lab Anal 22:239-45. 2008
    ..The sensitivity, working range, cross reactivity, accuracy, precision, and reproducibility were examined...
  45. doi Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages
    Shilpa Kumar-Roine
    Universite de Toulouse, UPS, UMR 152 Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, 118 Rte de Narbonne, F 31062 Toulouse Cedex 9, France
    J Ethnopharmacol 123:369-77. 2009
    ..Many traditional remedies are commonly used in the Pacific against CFP. In this context, bioassay-guided screening was carried out to study NO inhibiting capacity of 28 selected plant extracts...
  46. ncbi Poisoning, envenomation, and trauma from marine creatures
    R Allen Perkins
    Department of Family Medicine, University of South Alabama College of Medicine, Mobile, Alabama 36604, USA
    Am Fam Physician 69:885-90. 2004
    ..Poisoning, envenomation, and direct trauma are all possible in the marine environment. Ciguatera poisoning can result from ingestion of predatory fish that have accumulated biotoxins...
  47. ncbi Paralytic shellfish poisoning (PSP) in Margarita Island, Venezuela
    Amelia La Barbera-Sanchez
    Centro de Investigaciones Agropecuarias de Sucre Nva Esparta, INIA, MCT Av Carupano, sector Caiguire, Cumana, Estado Sucre, Venezuela
    Rev Biol Trop 52:89-98. 2004
    ..The presence of dcSTX and dcGTX in shellfish is indicative that Gymnodinium catenatum was a causative organism for outbreak of PSP...
  48. ncbi Epiphytic dinoflagellates associated with ciguatera in the northwestern coast of Cuba
    Gilma Delgado
    Centro de Investigaciones Pesqueras, 5a Avenida y Calle 246, Barlovento, Santa Fe, Playa, P O de La Habana, Cuba
    Rev Biol Trop 54:299-310. 2006
    ....
  49. ncbi Caribbean ciguatera: a changing paradigm
    T R Tosteson
    Department of Marine Sciences, University of Puerto Rico Mayaguez, Isla Magueyes Marine Station, P O Box 908 Lajas
    Rev Biol Trop 52:109-13. 2004
    ..These two changes, accompanied by the discovery that ciguatoxic fish contained a variety of multiple toxins, appear to be correlated with the steadily increasing periods of elevated sea surface temperatures in this region...
  50. doi Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice
    Jeanine S Morey
    Marine Biotoxins Program, NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina 29414, USA
    Toxicol Sci 103:298-310. 2008
    ..In addition to Cyps, increases in several glutathione S-transferases were observed, an indication that both phase I and phase II metabolic reactions are involved in the hepatic response to CTX in mice...
  51. ncbi Food poisoning
    David T Lawrence
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:357-73; abstract ix. 2007
    ..This article reviews several potential food-borne poisons and describes each agent's mechanism of toxicity, expected clinical presentation, and currently accepted treatment...
  52. ncbi [Ciguatera: clinical relevance of a marine neurotoxin]
    K Ruprecht

    Dtsch Med Wochenschr 126:812-4. 2001
    ..In the early phase of the disease intravenous therapy with mannitol has emerged as an efficient treatment...
  53. ncbi The transport of ciguatoxin: a case report
    G Asaeda
    Department of Emergency Medicine, Coney Island Hospital, Brooklyn, New York, USA
    J Emerg Med 20:263-5. 2001
    ..This is a case report of such a patient who was evaluated and discharged only to subsequently return because of worsening of symptoms...
  54. ncbi Ciguatera fish poisoning: impact for the military health care provider
    Michael V Arnett
    Department of Medicine, Tripler Army Medical Center, MCHK DM, 1 Jarrett White Road, Honolulu, HI 96859, USA
    Mil Med 172:1012-5. 2007
    ..for case clusters from a common source ingestion of contaminated fish, there is the potential that ciguatera poisoning may initially mimic illnesses caused by antipersonnel biological and chemical agents...
  55. pmc TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
    Eva Cuypers
    Laboratorium voor Toxicologie, Campus Gasthuisberg, Herestraat 49, bus 922, KULeuven, B 3000, Belgium
    Biochem Biophys Res Commun 361:214-7. 2007
    ..Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions...
  56. ncbi [Ciguatera: from the etiology of the phenomenon to the treatment of its symptoms]
    Raphaële Boydron-Le Garrec
    Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152, IRD Université Paul Sabatier, Centre IRD de Noumea, BP A5, 98848 Noumea, Nouvelle Calédonie
    J Soc Biol 199:127-39. 2005
    ..The ciguateric intoxication tends to be exported towards non endemic areas where it is still misdiagnosed. No specific antidote exists to date, and it is only by symptomatic or palliative treatments that ciguatera is currently treated...
  57. ncbi [Evaluation of Antilles fish ciguatoxicity by mouse and chick bioassays]
    I Pottier
    Laboratoire de microbiologie alimentaire U S C INRA, Universite de Caen, Esplanade de la Paix, 14032 Caen, France
    Bull Soc Pathol Exot 96:24-8. 2003
    ..This study confirms the usefulness of mouse and chick bioassays for sanitary control of fish...
  58. ncbi [Seafood poisoning through marine biotoxins]
    Sophie Krys
    Rev Prat 52:2209-11. 2002
  59. ncbi Isolation of Prorocentrum lima (Syn. Exuviaella lima) and diarrhetic shellfish poisoning (DSP) risk assessment in the Gulf of California, Mexico
    A Heredia-Tapia
    The Northwest Center for Biological Research SC, P O Box 128, La Paz, Baja California Sur, Mexico City 23000, Mexico
    Toxicon 40:1121-127. 2002
    ..This is the first report of a successful isolation and culturing of a toxic dinoflagellate from the Gulf of California, Mexico...
  60. ncbi Total synthesis of gambierol: the generation of the A-C and F-H subunits by using a C-glycoside centered strategy
    Utpal Majumder
    University of Utah, Department of Chemistry, 315 South 1400 East, Salt Lake City, Utah 84112, USA
    Chemistry 12:1736-46. 2006
    ..Fundamental work included efforts to C-glycosides and C-ketosides, Claisen rearrangements, and enol ether-olefin RCM reactions...
  61. ncbi Is fish consumption safe?
    James H Diaz
    School of Public Health at Louisiana State University Health Sciences Center, New Orleans, USA
    J La State Med Soc 156:42, 44-9. 2004
    ....
  62. ncbi Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX
    Y Hokama
    Department of Pathology, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA
    J Clin Lab Anal 17:132-9. 2003
    ..This was compatible with the neuroblastoma assay demonstrated in the C(18) column fractions 9:1 and 1:1, chloroform : methanol solvents...
  63. ncbi [Detection of ciguatoxins: advantages and drawbacks of different biological methods]
    Raphaële Boydron-Le Garrec
    Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152, IRD Université Paul Sabatier, Centre IRD de Noumea, BP A5, 98848 Noumea, Nouvelle Calédonie
    J Soc Biol 199:115-25. 2005
    ..Finally, the mouse neuroblastoma and rat brain synaptosome assays, carried out in vitro as alternative approaches to animal-using assays, are highly sensitive and much more specific than the in vivo methods to detect ciguatoxins...
  64. ncbi [Ciguatera poisoning in Spanish travellers]
    Joaquim Gascon
    Sección de Medicina Tropical Centro de Salud Internacional Hospital Clínic IDIBAPS Barcelona España
    Med Clin (Barc) 120:777-9. 2003
    b>Ciguatera poisoning appears after ingestion of contaminated fish from tropical coral reefs. Due to the diversity of clinical symptoms and the absence of a specific test in humans, the diagnosis is often difficult.
  65. ncbi Clinical problem-solving. A twist of fate?
    Michael D Christian
    Department of Medicine, University of Toronto, Toronto
    N Engl J Med 351:69-73. 2004
  66. ncbi Ciguatera poisoning in Vanuatu
    Anna Goodman
    Department of Paediatrics, St Mary s Hospital, Imperial College, London, United Kingdom
    Am J Trop Med Hyg 68:263-6. 2003
    b>Ciguatera poisoning is endemic in many tropical and subtropical countries. We conducted a retrospective study of admissions to two hospitals on the islands of Vanuatu in the southwestern Pacific region...
  67. doi First toxin profile of ciguateric fish in Madeira Arquipelago (Europe)
    Paz Otero
    Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain
    Anal Chem 82:6032-9. 2010
    ..Fishes from this genus were implicated in previous suspected ciguatera poisoning outbreaks in the Portuguese Madeira Arquipelago in the North Atlantic Ocean...
  68. ncbi A semi-quantitative seafood safety risk assessment
    John Sumner
    Centre for Food Safety and Quality, School of Agricultural Science, University of Tasmania, Hobart, Australia
    Int J Food Microbiol 77:55-9. 2002
    ..There have been significant (>100 cases) food poisoning incidents involving viruses and biotoxins in shellfish, while ciguatera poisoning is prevalent among coastal communities in Australia's warmer waters.
  69. doi Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning
    I Stewart
    Chemical Analysis, Queensland Health Forensic and Scientific Services, P O Box 594, Archerfield, Queensland, 4108, Australia
    Ann Trop Med Parasitol 104:557-71. 2010
    b>Ciguatera poisoning is a food-borne neuro-intoxication caused by consumption of finfish that have accumulated ciguatoxins in their tissues...
  70. doi Establishing a public health analytical service based on chemical methods for detecting and quantifying Pacific ciguatoxin in fish samples
    Ian Stewart
    Queensland Health Forensic and Scientific Services, Coopers Plains, Queensland 4108, Australia
    Toxicon 56:804-12. 2010
    ..or inadvertent misidentification, which may have implications for the management and prevention of ciguatera poisoning. Blinded inspection of case notes from suspect ciguatera poisoning cases showed that reporting of ciguatera-..
  71. ncbi Ciguatoxin-like substances in edible fish on the eastern Mediterranean
    Yedidia Bentur
    Israel Poison Information Center, Rambam Health Care Campus, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Clin Toxicol (Phila) 45:695-700. 2007
    The consumption of edible fish (e.g., Siganus spp) was assumed to have caused ciguatera poisoning at an atypical site, the eastern Mediterranean...
  72. pmc A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol
    Ivan Kopljar
    Laboratory for Molecular Biophysics, Physiology, and Pharmacology, University of Antwerp, 2610 Antwerp, Belgium
    Proc Natl Acad Sci U S A 106:9896-901. 2009
    ..neurotoxin site may have wide implications not only for our understanding of channel function at the molecular level but for future development of drugs to alleviate ciguatera poisoning or to modulate electrical excitability in general.
  73. ncbi Hallucinatory fish poisoning (ichthyoallyeinotoxism): two case reports from the Western Mediterranean and literature review
    Luc De Haro
    Toxicovigilance, Centre Antipoison, Hopital Salvator, Marseille, France
    Clin Toxicol (Phila) 44:185-8. 2006
    ..As the implicated fish species may be also related to ciguatera poisoning, there may be possible confusion between the two fish-borne intoxications...
  74. doi Total synthesis of ciguatoxin
    Akinari Hamajima
    Laboratory of Organic Chemistry, Bioagricultural Sciences, Nagoya University, Furocho, Chikusa 464 8601, Nagoya, Japan
    Angew Chem Int Ed Engl 48:2941-5. 2009
    Something fishy: Ciguatoxin (see structure) is one of the principal toxins involved in ciguatera poisoning and the target of a total synthesis involving the coupling of three segments...
  75. doi Reversible cerebellar dysfunction associated with ciguatera fish poisoning
    Sun Young Oh
    Department of Neurology, Chonbuk National University Medical School, Jeonju, South Korea
    J Emerg Med 43:674-6. 2012
    ..Ciguatera-fish poisoning (or ciguatera) is a common but underdiagnosed food-borne illness related to fish consumption that is characterized by nausea, vomiting and neurologic symptoms such as tingling in the fingers or toes...
  76. ncbi [Ca(2+)]-dependent generation of intracellular reactive oxygen species mediates maitotoxin-induced cellular responses in human umbilical vein endothelial cells
    Sun Ju Yi
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chunchon 200 701, Korea
    Mol Cells 21:121-8. 2006
    Maitotoxin (MTX) is known as one of the most potent marine toxins involved in Ciguatera poisoning, but intracellular signaling pathways caused by MTX was not fully understood...
  77. pmc Assessing the incidence of ciguatera fish poisoning with two surveys conducted in Culebra, Puerto Rico, during 2005 and 2006
    Eduardo Azziz-Baumgartner
    US Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:526-9. 2012
    ..Although ciguatera fish poisoning (CFP) is the most common seafood intoxication worldwide, its burden has been difficult to establish because there are no biomarkers to diagnose human exposure...
  78. pmc Linking ciguatera poisoning to spatial ecology of fish: a novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry
    Amanda C O'Toole
    Fish Ecology and Conservation Physiology Laboratory, Department of Biology, Carleton University, 1125 Colonel By Dr, Ottawa, Ontario, Canada K1S 5B6
    Sci Total Environ 427:98-105. 2012
    ....
  79. ncbi A case of ciguatera fish poisoning in a French traveler
    M Develoux
    Service des Maladies Infectieuses et Tropicales, Hôpital Tenon APHP, Paris, France
    Euro Surveill 13:pii: 19027. 2008
    ..Ciguatera is a toxic poisoning due to ingestion of fish and is rarely reported in France. Little is known about this imported tropical disease. We present a case observed in Paris in a traveller returning from the Dominican Republic...
  80. ncbi Two patients with ciguatera toxicity: a seafood poisoning in travellers to (sub) tropical areas
    L Slobbe
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Neth J Med 66:389-91. 2008
    ..Most cases originate in the (sub)tropics but due to expanding tourism and fish exportation, it may be encountered in more temperate regions. Treatment is supportive, but some benefit from intravenous mannitol has been reported...
  81. doi Marine toxic cyanobacteria: diversity, environmental responses and hazards
    Stjepko Golubic
    Biological Science Center, Boston University, Boston, MA 02215, USA
    Toxicon 56:836-41. 2010
    ..The questions addressed include the distinction between marine and freshwater taxa, between populations in geographically separate regions as well as between their potential vs. expressed toxicity...
  82. doi Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration
    Marie Yasmine Dechraoui Bottein
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Toxicology 284:1-6. 2011
    ..Blood, as well as urine and feces may be useful matrices for low-invasive testing methods for ciguatera clinical cases...
  83. doi The first F-ring modified ciguatoxin analogue showing significant toxicity
    Yuuki Ishihara
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Chem Commun (Camb) 46:2968-70. 2010
    ..We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity...
  84. ncbi Species identification of ciguatoxin-carrying grouper implicated in food poisoning
    Cheng Hong Hsieh
    Department of Applied Life Science, Asia University, Taichung County, Taiwan
    J Food Prot 72:2375-9. 2009
    ..This study indicated that DNA sequence and restriction enzyme analysis are powerful methods for identifying potentially toxic red grouper species as L. bohar...
  85. ncbi [Ciguatera and acute polyradiculoneuritis. Description of two cases in French Polynesia: immunoallergic hypothesis?]
    E Oehler
    Service de Medecine, Centre Hospitalier de Polynésie française CHPf
    Med Trop (Mars) 69:75-7. 2009
    ..The hypothesis of an immune-allergic reaction is raised especially in the light of rapid improvement of the patient who received polyvalent immunoglobulin treatment...
  86. doi Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: a case/control study
    Ritchie C Shoemaker
    Center for Research on Biotoxin Associated Illnesses, Pocomoke, MD, USA
    Neurotoxicol Teratol 32:633-9. 2010
    ..Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish...
  87. pmc Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells
    Cesar Mattei
    CNRS, Institut de Neurobiologie Alfred Fessard, Laboratoire de Neurobiologie Cellulaire et Moleculaire, Gif sur Yvette, France
    PLoS ONE 3:e3448. 2008
    ..Brevenal is therefore a potent inhibitor of ciguatoxin-induced neurotoxic effect and a potential treatment for ciguatera...
  88. ncbi A Queensland family with ciguatera after eating coral trout
    P J Fenner
    Queensland Agricultural Biotechnology Centre, University of Queensland, Brisbane
    Med J Aust 166:473-5. 1997
    ..At birth, the infant appeared to suffer no adverse effects attributable to ciguatera; to our knowledge, this is the first report of the effect of severe ciguatera in the first trimester of pregnancy...
  89. ncbi Neurological symptoms in a traveller returning from Central America
    Y Keynan
    Infectious Diseases Unit, Bnei Zion Medical Center, Haifa, Israel
    J Intern Med 256:174-5. 2004
  90. ncbi Short report: persistent bradycardia caused by ciguatoxin poisoning after barracuda fish eggs ingestion in southern Taiwan
    Yao Min Hung
    Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Taiwan
    Am J Trop Med Hyg 73:1026-7. 2005
    ..In two patients with ciguatoxin poisoning after barracuda fish egg ingestion, persistent bradycardia required prolonged atropine infusion...
  91. ncbi Study of an outbreak of ciguatera fish poisoning in Hong Kong
    Joanne S M Yoshikawa Ebesu
    Toxicon 48:467-9; author reply 470-2. 2006
  92. doi Solid-phase extraction clean-up of ciguatoxin-contaminated coral fish extracts for use in the mouse bioassay
    Chun Kwan Wong
    Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Kowloon, Hong Kong, China
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:236-47. 2009
    ..The use of acetone-methanol (7:3, v/v) condition in the elution could significantly improve overall recovery of CTXs, while minimizing the possible interferences of lipid matrix from co-extractants on mice...
  93. ncbi Biotechnological significance of toxic marine dinoflagellates
    F Garcia Camacho
    Department of Chemical Engineering, University of Almeria, 04120 Almeria, Spain
    Biotechnol Adv 25:176-94. 2007
    ..Production and processing of dinoflagellates to extract bioactives, require attention to biosafety considerations as outlined in this review...
  94. ncbi Metabolic and toxic peripheral neuropathies including diabetes
    T J Walls
    Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Curr Opin Neurol Neurosurg 5:375-8. 1992
    ..Recent work on the molecular basis of hereditary amyloidosis is initially considered followed by various aspects of diabetic neuropathy and then the effects of ciguatoxin and podophyllin on peripheral nerves...
  95. ncbi [Neurological features after consumption of a variety of neo-caledonian shellfish]
    G Angibaud
    Service de Neurologie, CHT Gaston Bourret, Noumea, Nouvelle Calédonie
    Rev Neurol (Paris) 156:65-6. 2000
    ..However, no toxicologic assay was performed. To our knowledge, this poisoning has never been reported with trocas. Nevertheless, the feeding habits of trocas would suggest similarity with ciguatera poisoning.
  96. pmc Neurology of ciguatera
    J Pearn
    Graduate School of Medicine, University of Queensland, and Department of Paediatrics and Child Health, Royal Children s Hospital, Brisbane, Queensland 4029, Australia
    J Neurol Neurosurg Psychiatry 70:4-8. 2001
    ..b>Ciguatera poisoning is little known in temperate countries as a potentially global problem associated with human ingestion of ..
  97. ncbi Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1
    James C Ryan
    Marine Biotoxins Program, NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, United States
    Neurotoxicology 28:1099-109. 2007
    ..In large part, the gene expression was consistent with a Th2 immune response with interesting similarities to expression seen in asthmatic models...
  98. ncbi A brief case report and review of ciguatera poisoning
    D J Farstad
    Department of Emergency Medicine, United Medical Center, Cheyenne, WY, USA
    Wilderness Environ Med 12:263-9. 2001
    ..As access to tropical locations has increased, so has the distribution of ciguatera. Herein, we present a case report and review the current literature on ciguatera...
  99. ncbi Ciguatera poisoning
    Uzi M Selcer
    N Engl J Med 351:2020; author reply 2020. 2004
  100. pmc Peak occurrences of ciguatera fish poisoning precede cholera outbreaks in Hong Kong
    L C Kwan
    Port Health Office, Hong Kong
    Epidemiol Infect 131:621-6. 2003
    ..CFP peaks served as an early warning for public measures to be in place before occurrence of cholera outbreaks...
  101. ncbi Emergence of imported ciguatera in Europe: report of 18 cases at the Poison Control Centre of Marseille
    Luc De Haro
    Centre Antipoison Hôpital Salvator, Marseille, France
    J Toxicol Clin Toxicol 41:927-30. 2003
    ..This dinoflagellate is frequently found in damaged coral reef systems. Previously rare in Europe, this disease entity is now seen in tourists returning from tropical countries...

Research Grants3

  1. FUNGICIDAL AND NEUROTOXIC MARINE NATURAL PRODUCTS
    Jon Rainier; Fiscal Year: 2003
    ..The first of these is gambierol, a marine ladder toxin associated with ciguatera poisoning. The second is armatol A, a polycyclic ether that has demonstrated interesting cytotoxicity in preliminary ..
  2. FUNGICIDAL AND NEUROTOXIC MARINE NATURAL PRODUCTS
    Jon Rainier; Fiscal Year: 2006
    ..The first of these is gambierol, a marine ladder toxin associated with ciguatera poisoning. The second is armatol A, a polycyclic ether that has demonstrated interesting cytotoxicity in preliminary ..