alcoholic pancreatitis

Summary

Summary: Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.

Top Publications

  1. ncbi Alcohol-induced pancreatic injury
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe, Australia
    Best Pract Res Clin Gastroenterol 17:593-612. 2003
  2. pmc VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
    Laura I Cosen-Binker
    Department of Medicine, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Clin Invest 118:2535-51. 2008
  3. ncbi Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
    A Casini
    Alcohol Research Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Pathol 192:81-9. 2000
  4. ncbi Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis
    B Yang
    Molecular Medicine Research Group, Plymouth Postgraduate Medical School, ITTC Building, University of Plymouth, Tamar Science Park, Derriford Road, PL6 8BX, Plymouth, UK
    Alcohol 23:91-7. 2001
  5. ncbi Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis
    Vasile Drug
    University of Medicine and Pharmacy Gr T Popa, Institute of Gastroenterology and Hepatology, Iasi, Romania
    J Gastrointestin Liver Dis 18:367-9. 2009
  6. ncbi Alcoholic pancreatitis
    Alexander Schneider
    Department of Medicine II Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:222-31. 2005
  7. doi Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis
    Lutz Schneider
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 39:502-9. 2010
  8. ncbi Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis
    Thomas R Jerrells
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Leukoc Biol 81:430-9. 2007
  9. ncbi [Pyogenic liver abscess in chronic alcoholic pancreatitis]
    F Gundling
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Dtsch Med Wochenschr 129:1679-82. 2004
  10. ncbi A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008

Detail Information

Publications193 found, 100 shown here

  1. ncbi Alcohol-induced pancreatic injury
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe, Australia
    Best Pract Res Clin Gastroenterol 17:593-612. 2003
    b>Alcoholic pancreatitis is a major complication of alcohol abuse. Until recently, it was generally accepted that alcoholic pancreatitis was a chronic disease from the outset...
  2. pmc VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
    Laura I Cosen-Binker
    Department of Medicine, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Clin Invest 118:2535-51. 2008
    ..Cch-stimulated amylase release by redirecting apical exocytosis to the basolateral membrane, leading to alcoholic pancreatitis. Further reduction of zymogen secretion, caused by blockade of both apical and basolateral exocytosis and ..
  3. ncbi Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
    A Casini
    Alcohol Research Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Pathol 192:81-9. 2000
    Chronic alcoholic pancreatitis (CAP) is characterized by progressive pancreatic fibrosis and loss of the acinar cell mass, but the pathogenesis of pancreatic fibrosis in the human is poorly understood...
  4. ncbi Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis
    B Yang
    Molecular Medicine Research Group, Plymouth Postgraduate Medical School, ITTC Building, University of Plymouth, Tamar Science Park, Derriford Road, PL6 8BX, Plymouth, UK
    Alcohol 23:91-7. 2001
    ..at position -1019 [C(-1019)T], 4808 [G(4808)A], and 7668 [T(7668)A] of the CYP2E1 gene are associated with alcoholic pancreatitis. DNA was extracted from peripheral blood of 38 patients with alcoholic chronic pancreatitis (CP), 19 ..
  5. ncbi Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis
    Vasile Drug
    University of Medicine and Pharmacy Gr T Popa, Institute of Gastroenterology and Hepatology, Iasi, Romania
    J Gastrointestin Liver Dis 18:367-9. 2009
    ..The patient had no evident immunosupression (HIV negative and absence of immunosupressive therapy). This is the first reported case where acute pancreatitis could have precipitated infection of ascitic fluid with S. stercoralis...
  6. ncbi Alcoholic pancreatitis
    Alexander Schneider
    Department of Medicine II Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:222-31. 2005
    ..Finally, this article summarizes several hypothetical concepts that try to explain the early and late pathophysiological mechanisms of acute and chronic pancreatitis...
  7. doi Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis
    Lutz Schneider
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 39:502-9. 2010
    Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage...
  8. ncbi Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis
    Thomas R Jerrells
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Leukoc Biol 81:430-9. 2007
    ..This apparent paradox has led to the notion that additional cofactors are involved in the development of alcoholic pancreatitis. Potential cofactors, such as diet and smoking, have been suggested, but there are no compelling ..
  9. ncbi [Pyogenic liver abscess in chronic alcoholic pancreatitis]
    F Gundling
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Dtsch Med Wochenschr 129:1679-82. 2004
    ..A 44-year-old patient was transferred for further treatment of pyogenic liver abscess and a severe attack of a chronic pancreatitis for strong upper right quadrant abdominal pain and recurring fever...
  10. ncbi A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
    ..The results indicate that alcohol impairs recovery from acute pancreatitis, suggesting a mechanism by which alcohol sensitizes pancreas to chronic injury...
  11. ncbi Theories, mechanisms, and models of alcoholic chronic pancreatitis
    Nevin Oruc
    Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 33:733-50, v-vi. 2004
    ....
  12. ncbi Stellate cell activation in alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Pancreas 27:316-20. 2003
    ....
  13. ncbi Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models
    Stephen J Pandol
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258, Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    J Gastroenterol 38:623-8. 2003
    ..These pathologic processes include inflammation, cell death, intrapancreatic digestive enzyme activation, and fibrosis...
  14. ncbi Gene-environment factors that contribute to alcoholic pancreatitis in humans
    David C Whitcomb
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Gastroenterol Hepatol 21:S52-5. 2006
    ..Human studies suggest that PRSS1 and SPINK1 mutation increase the pancreas' susceptibility to alcohol-associated pancreatitis, and that tobacco smoking, and some factors, affect disease progression...
  15. ncbi Pathobiology of alcoholic pancreatitis
    Stephen J Pandol
    Department of Medicine, University of California, Department of Veterans Affairs, Los Angeles, California, USA
    Pancreatology 7:105-14. 2007
    ....
  16. ncbi Genetic polymorphisms in alcoholic pancreatitis
    Christoph Hanck
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, PUH, University of Pittsburgh, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Best Pract Res Clin Gastroenterol 17:613-23. 2003
    ..However, the major cofactor associated with alcoholic chronic pancreatitis is yet to be identified...
  17. ncbi Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol
    Jens Werner
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 283:G65-73. 2002
    ....
  18. ncbi Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis
    Christoph H Osterreicher
    Department of Medicine, Columbia University, NY, USA
    Mutagenesis 22:305-10. 2007
    ..by polymerase chain reaction and restriction fragment length polymorphism in 165 patients with chronic alcoholic pancreatitis, 140 alcoholics without evidence of pancreatic disease and 160 healthy control subjects...
  19. ncbi Animal models and their results in gastrointestinal alcohol research
    Soren V Siegmund
    Department of Medicine II Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:181-94. 2005
    ..For some alcohol-related diseases like chronic alcoholic pancreatitis, the ideal animal model does not yet exist...
  20. doi Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells
    Carmel Lawrencia
    The Research Institute at Nationwide Children s Hospital, Center for Cell and Developmental Biology, Columbus, OH, USA
    Growth Factors 27:91-9. 2009
    ..The potential therapeutic effects of inhibitors of ethanol metabolism or anti-oxidants in alcoholic pancreatitis may arise in part through their ability to attenuate CCN2 production by PSC.
  21. doi New insights into alcoholic pancreatitis and pancreatic cancer
    Minoti Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 24:S51-6. 2009
    ..This review summarizes recent advances in our understanding of the pathogenesis of alcoholic pancreatitis and pancreatic cancer, with particular reference to the central role played by PSCs in both diseases...
  22. ncbi The epidemiology of alcohol-induced pancreatitis
    Mary C Dufour
    Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 7003, USA
    Pancreas 27:286-90. 2003
    ..Unfortunately, no code yet exists for acute alcoholic pancreatitis. Of the approximately 2...
  23. ncbi Role of alcohol metabolism in alcoholic pancreatitis
    J S Wilson
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Pancreas 27:311-5. 2003
    ..metabolizing enzymes have been examined to determine whether they may confer individual susceptibility to alcoholic pancreatitis. However, no association has been demonstrated between ADH and CYP2E1 polymorphisms and the predisposition ..
  24. ncbi Alcoholic pancreatitis: new pathogenetic insights
    L Lucrezio
    Internal Medicine Institute, University of Bologna, Sant Orsola Hospital, Via Massarenti 9, Bologna, Italy
    Minerva Med 99:391-8. 2008
    Though amply described, alcoholic pancreatitis continues to stir controversy. One of the most debated points is whether it is a chronic disease since onset or progresses to a chronic form after repeated episodes of acute pancreatitis...
  25. pmc Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma
    Andreas Gerloff
    Department of Medicine II, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Int J Environ Res Public Health 7:1093-104. 2010
    ..of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma...
  26. ncbi What is the risk of alcoholic pancreatitis in heavy drinkers?
    Paul Georg Lankisch
    Pancreas 25:411-2. 2002
  27. ncbi Purtscher's like retinopathy as the presenting feature of acute alcoholic pancreatitis
    H Devonport
    Eye (Lond) 20:255-7. 2006
  28. ncbi Molecular mechanisms of alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Dig Dis 23:232-40. 2005
    b>Alcoholic pancreatitis is a major complication of alcohol abuse. Since only a minority of alcoholics develop pancreatitis, there has been a keen interest in identifying the factors that may confer individual susceptibility to the disease...
  29. ncbi Does acute alcoholic pancreatitis precede the chronic form or is the opposite true? A histological study
    Marina Migliori
    Institute of Internal Medicine, University of Bologna, Sant Orsola Hospital, Bologna, Italy
    J Clin Gastroenterol 38:272-5. 2004
    Whether acute alcoholic pancreatitis occurs in a normal pancreas or in a pancreas that has already been altered by chronic pancreatitis is unclear...
  30. ncbi Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital, Sydney, Australia
    J Gastroenterol Hepatol 21:S97-S101. 2006
    ....
  31. ncbi Pathophysiology of alcoholic pancreatitis: an overview
    Parimal Chowdhury
    Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, Arkansas 72205, United States
    World J Gastroenterol 12:7421-7. 2006
    ..Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented...
  32. ncbi Two cases of thoracopancreatic fistula in alcoholic pancreatitis: clinical and CT findings
    Hisao Ito
    Department of Diagnostic Radiology, Miyagi Prefectural Semine Hospital, Osato, Japan
    Radiat Med 20:207-11. 2002
    ....
  33. doi Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study
    Louise Kristiansen
    National Institute of Public Health, Oster Farimagsgade 5A, DK 1399 Copenhagen K, Denmark
    Am J Epidemiol 168:932-7. 2008
    ..4, 4.8), and 3.0 (95% CI: 1.6, 5.7), respectively, compared with 0 drinks/week (P(trend) < 0.001). Associations were similar for men and women. Drinking frequency did not seem to be independently associated with pancreatitis...
  34. ncbi The natural history of alcoholic chronic pancreatitis
    R W Ammann
    Gastroenterology, University of Zurich, Switzerland
    Intern Med 40:368-75. 2001
    ..From our experience, the relief of "chronic" pain regularly follows selective surgery tailored to the presumptive pain cause or it occurs spontaneously in uncomplicated advanced CP (excluding narcotic addiction)...
  35. doi Individual susceptibility to alcoholic pancreatitis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital, The University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 23:S63-8. 2008
    ..this concerted research effort, no clear association has been established between the above factors and alcoholic pancreatitis. Experimentally, the secretagogue cholecystokinin (CCK) has been investigated as a candidate 'trigger' for ..
  36. ncbi High complication rate of bile duct stents in patients with chronic alcoholic pancreatitis due to noncompliance
    K Kiehne
    I Department of Medicine, Christian Albrechts University Kiel, Germany
    Endoscopy 32:377-80. 2000
    ..The aim of this study is to analyze the frequency and severity of complications caused by biliary stents in patients with chronic alcoholic pancreatitis.
  37. ncbi Acute septal panniculitis. A cutaneous marker of a very early stage of pancreatic panniculitis indicating acute pancreatitis
    Maria Antony Johnson
    Centre for GI Bleed and Division of Hepato Biliary Pancreatic Diseases, Department of Surgical Gastroenterology, Government Stanley Medical College Hospital, Affiliated to the Tamilnadu Dr M G R Medical University, Chennai, India
    JOP 6:334-8. 2005
    ..Pancreatic panniculitis is rare, occurring in 2-3% of all patients with pancreatic disorders, with a higher incidence among alcoholic males...
  38. ncbi Activated perilobular, not periacinar, pancreatic stellate cells contribute to fibrogenesis in chronic alcoholic pancreatitis
    Koichi Suda
    Department of Pathology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Pathol Int 57:21-5. 2007
    ..Twenty-four patients with clinically diagnosed chronic alcoholic pancreatitis were studied histopathologically, immunohistochemically and quantitatively...
  39. ncbi Animal models in alcoholic pancreatitis--what can we learn?
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology and Hepatology, Human Genetics, Cell Biology and Physiology, University of Pittsburgh, PA, USA
    Pancreatology 2:189-203. 2002
    ..pancreatitis present a history of excessive alcohol consumption, the pathophysiology underlying chronic alcoholic pancreatitis remains poorly defined...
  40. ncbi Incidence of alcoholic pancreatitis in Japanese alcoholics: survey of male sobriety association members in Japan
    Katsuya Maruyama
    Department of Clinical Research, National Hospital Organization, Kurihama Alcoholism Center, Kurihama, Japan
    Pancreas 34:63-5. 2007
    To estimate the incidence of alcoholic pancreatitis, a dependence questionnaire survey was administered to male members of the sobriety association in Japan.
  41. ncbi Severe chronic pancreatitis and severe liver cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics
    Yuji Nakamura
    National Alcoholism Center, Kurihama National Hospital, 5 3 1 Nobi, 239 0841 Yokosuka, Japan
    J Gastroenterol 39:879-87. 2004
    ..This study was designed to examine a possible association between alcoholic chronic pancreatitis (ACP) and alcoholic liver cirrhosis (ALC), and to identify factors relating to them...
  42. ncbi Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, Sydney, Australia
    Gastroenterology 133:1293-303. 2007
    ....
  43. ncbi [Ethanol metabolism in pancreas and its role in alcoholic pancreatitis]
    Lech Chrostek
    Zakład Diagnostyki Biochemicznej, Akademii Medycznej w Białymstoku
    Pol Arch Med Wewn 114:989-96. 2005
  44. doi Mortality in alcohol and biliary acute pancreatitis
    Anders Møller Andersen
    Pancreas 36:432-4. 2008
  45. doi Validation of fecal elastase-1 determination using immunoenzymatic assay in HIV-infected patients
    Claudia Giorgia Bronzatti de Oliveira
    Faculdade de Medicina do ABC, Sao Paulo, Brazil
    J Clin Lab Anal 22:286-90. 2008
    ..424). This test is useful to diagnose pathologies related to pancreatic insufficiency...
  46. ncbi [Role of cationic trypsinogen gene (PRSS-gene) mutations in the pathogenesis of chronic pancreatitis]
    I V Maev
    Klin Med (Mosk) 82:12-7. 2004
  47. ncbi [Acute pancreatitis: our experience in the light of natural history]
    M Barbuscia
    Universita degli Studi di Messina, Cattedra di Chirurgia dell Apparato Digerente
    G Chir 25:306-12. 2004
    ..They conclude stating how only proper diagnosis and treatment can prevent its potential evolution in multiorgan failure...
  48. ncbi Non-alcoholic duct destructive chronic pancreatitis: a histological, immunohistochemical and in-situ apoptosis study of 18 cases
    N Youssef
    Department of Pathology, Saint Antoine Hospital, Paris, France
    Histopathology 44:453-61. 2004
    ..To assess retrospectively pancreatic changes in non-alcoholic duct-destructive chronic pancreatitis and to investigate the role of apoptosis in duct destruction...
  49. ncbi [Re: Perforation of a pancreatic pseudocyst induced by abdominal sonography]
    C Jurgensen
    Z Gastroenterol 42:1241-2. 2004
  50. ncbi Clinical case of the month. Expanding abdominal mass in a 41-year-old patient with a history of alcohol abuse
    Racheed Ghanami
    Louisiana State University School of Medicine, New Orleans, USA
    J La State Med Soc 156:181-5. 2004
  51. ncbi Clinical implications of incomplete pancreas divisum
    Terumi Kamisawa
    Departments of Internal Medicine and Surgery, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    JOP 7:625-30. 2006
    ..Although the relationship between complete pancreas divisum and pancreatitis has been contentious, clinical implications of incomplete pancreas divisum have not been noted...
  52. ncbi Diminished cellular immune response to carbonic anhydrase II in patients with Sjögren's syndrome and idiopathic chronic pancreatitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School Nankoku, Kochi, Japan
    JOP 5:186-92. 2004
    ..A serum antibody to carbonic anhydrase II has been reported in patients with Sjögren's syndrome and idiopathic chronic pancreatitis...
  53. ncbi Clinical features of patients with chronic pancreatitis complicated by bile duct strictures
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Hepatogastroenterology 51:1191-5. 2004
    ..Distal bile duct stenosis is relatively rare in patients with non-alcoholic chronic pancreatitis...
  54. ncbi Chronic pancreatitis and malabsorption
    Chris E Forsmark
    Am J Gastroenterol 99:1355-7. 2004
  55. ncbi Etiology, severity and recurrence of acute pancreatitis in southern taiwan
    Chun Hao Chen
    Department of Internal Medicine, Municipal Hsiao Kang Hospital, Municipal United Hospital, Kaohsiung, Taiwan
    J Formos Med Assoc 105:550-5. 2006
    ..This study investigated the etiologies and factors associated with severity and recurrence of acute pancreatitis in southern Taiwan...
  56. ncbi [The multidisciplinary management of acute pancreatitis: a review of 244 cases]
    M Roseano
    Universita degli Studi di Trieste, Facolta di Medicina e Chirurgia, Dipartimento di Scienze Chirurgiche Generali, Anestesiologiche e Medicina Intensiva
    Ann Ital Chir 75:443-53. 2004
    ..The aim of this work is to valuate the accuracy of the prognostic factors actually employed and the results of a multidisciplinary treatment of the AP...
  57. doi Relationships among iron, protein oxidation and lipid peroxidation levels in rats with alcohol-induced acute pancreatitis
    Ali Riza Kiziler
    Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Biol Trace Elem Res 124:135-43. 2008
    ..These results suggest that elevated Fe levels in serum and pancreatic tissue in rats with early-stage alcohol-induced acute pancreatitis is associated with various hemorheological changes and with oxidative damage of the pancreas...
  58. ncbi Criteria for alcoholic pancreatitis. Results of an international workshop in Tampere, Finland, June 2006
    I Nordback
    Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Pancreatology 7:100-4. 2007
  59. pmc Fatal pancreatic panniculitis associated with acute pancreatitis: a case report
    Woo Sun Lee
    Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 22:914-7. 2007
    ..Laboratory and radiologic findings revealed acute pancreatitis, and skin biopsy showed pancreatic panniculitis. Despite intensive medical care, he died of multi-organ failure 3 weeks after presentation...
  60. ncbi Vascular complications of pancreatitis
    Richard M Mendelson
    Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia, Australia
    ANZ J Surg 75:1073-9. 2005
    ..This review, with illustrative cases, describes the main manifestations of these complications and emphasizes the importance of early radiological diagnosis and intervention...
  61. ncbi Signal transduction in alcohol-related diseases
    Minoti V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Alcohol Clin Exp Res 29:1299-1309. 2005
  62. ncbi [Effects of alcohol on the upper gastrointestinal tract and the pancreas--an up-to-date overview]
    S V Siegmund
    II Medizinische Universitätsklinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Universitatsklinikum Mannheim
    Z Gastroenterol 43:723-36. 2005
    ..Chronic alcohol abuse may cause chronic alcoholic pancreatitis after recurrent subclinical inflammatory episodes...
  63. ncbi [Mortality and morbidity in patients with alcohol and biliary-induced acute pancreatitis]
    Anders Møller Andersen
    Bispebjerg Hospital, Kirurgisk Gastroenterologisk Afdeling K, Købehavn NV
    Ugeskr Laeger 169:4351-4. 2007
    ..Acute Pancreatitis (AP) is a serious disease with a high mortality. The main aetiological factors involved in development of AP are alcohol and gallstones. Whether aetiology influences mortality and morbidity in AP is not clarified...
  64. ncbi [Chronic pancreatitis]
    Philippe Levy
    Fédération Médico Chirurgicale d Hépato Gastro Entérologie, Hopital Beaujon, AP HP, 92118 Clichy
    Rev Prat 52:997-1000. 2002
  65. ncbi [Chronic pancreatis and pancreatic carcinoma in the elderly]
    M Otte
    Allgemeines Krankenhaus Wandsbek, II Medizinische Abteilung, Abteilung für Gastroenterologie und Stoffwechselkrankheiten, Hamburg
    Praxis (Bern 1994) 94:943-8. 2005
    ..The Idiopathic Chronic Senile Pancreatitis (ICSP) is a subset of the non-alcoholic pancreatitis and is characterized by advanced age at the time of first manifestation...
  66. ncbi [Chronic pancreatitis--pancreas cancer: influence of genetic factors]
    V Keim
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig AoR
    Praxis (Bern 1994) 94:811-7. 2005
    ..These findings may be used in the future to develop newer therapeutic principles in order to improve the dismal prognosis of this disease...
  67. ncbi Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    ..6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer...
  68. ncbi Descriptive study of chronic calcific pancreatitis in Sri Lanka
    Mohan de Silva
    Faculty of Medical Sciences, University of Sri Jayawardenepura, Nugegoda, Sri Lanka
    Ceylon Med J 50:5-10. 2005
    ..To describe the potential risk factors, clinical features, biochemical and radiological features, and management of chronic calcific pancreatitis...
  69. pmc Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis
    L Aparisi
    Unit of Heptatology, University Clinic Hospital, Valencia, Spain
    Gut 54:703-9. 2005
    ..Increased serum antibodies against carbonic anhydrase II (CA-II Ab) or IgG4 levels have been reported in cases of autoimmune chronic pancreatitis (ACP)...
  70. ncbi Computed tomographic differentiation between alcoholic and gallstone pancreatitis: Significance of distribution of infiltration or fluid collection
    Young Sun Kim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    World J Gastroenterol 12:4524-8. 2006
    ..To evaluate the usefulness of various computed tomography (CT) findings including distribution of infiltration or fluid collection in differentiating the major etiologies of acute pancreatitis...
  71. ncbi [CME-Ultrasonography 4/Solution]
    J Tuma
    Weiter und Fortbildung SGUM Schweizerische Gesellschaft Für Ultraschall in der Medizin
    Praxis (Bern 1994) 94:615-7. 2005
  72. ncbi Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients
    Ezio Gaia
    Struttura Complessa di Gastroenterologia, Dipartimento di Clinica Medica, Azienda Ospedaliera San Luigi Gonzaga, Torino, Italy
    Dig Dis Sci 47:2416-21. 2002
    ..In conclusions, mutations in the genes investigated are involved in causing idiopathic pancreatitis. Such mutations have no connection either with the age at onset or the clinical course of the disease...
  73. ncbi Emergency pancreatoduodenectomy in nontrauma patients
    Kaspar Z'graggen
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Pancreas 24:258-63. 2002
    ..The indication for pancreatoduodenectomy has been expanded. Emergency pancreatoduodenectomy has mainly been performed for abdominal trauma...
  74. ncbi CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients
    Andrea L Ferreira Bernardino
    Human Genome Research Center, University of Sao Paulo, Sao Paulo, Brazil
    JOP 4:169-77. 2003
    ..However, the inheritance pattern is still not clear...
  75. ncbi Depletion of serum L-arginine in patients with acute pancreatitis
    Per Sandstrom
    Department of Biomedicine and Surgery, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Pancreas 27:261-6. 2003
    ..Acute pancreatitis may be initiated by interference with the pancreatic outflow to the duodenum. This flow is normally regulated by reflex relaxation of the sphincter of Oddi in which nitric oxide is an important mediator...
  76. ncbi Histopathological study on mechanism and background of tumor-forming pancreatitis
    M Takase
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Pathol Int 51:349-54. 2001
    ....
  77. ncbi Ultrastructural changes of pancreas of white rats after experimental administration of ethanol and cephalexin
    Alicja Zarebska
    Department of Histology and Embryology, Laboratory for Experimental Cytology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 57:452-8. 2002
    ..Administration of both ethanol and cephalexin causes reversible degenerative changes including distinct decreasing of the number of ribosomes, swelling of many mitochondria and the presence of myelinic structures inside cells...
  78. ncbi Development of an animal model of chronic alcohol-induced pancreatitis in the rat
    H Kono
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1178-86. 2001
    This study was designed to develop an animal model of alcoholic pancreatitis and to test the hypothesis that the dose of ethanol and the type of dietary fat affect free radical formation and pancreatic pathology...
  79. ncbi Early severe acute pancreatitis: characteristics of a new subgroup
    R Isenmann
    Department of General Surgery, University of Ulm, Germany
    Pancreas 22:274-8. 2001
    ..8), whereas biliary pancreatitis was associated with a slightly lower risk compared with alcoholic pancreatitis (odds ratio, 0.34)...
  80. pmc Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Gut 50:682-6. 2002
    ....
  81. ncbi Salivary gland involvement in chronic pancreatitis of various etiologies
    Terumi Kamisawa
    Department of Internal Medicine, Radiology, Tokyo Metropolitan Komagome Hospital, Japan
    Am J Gastroenterol 98:323-6. 2003
    ..To examine whether a cell-mediated phenomenon involving the pancreas has a secondary effect on the salivary glands, we assessed the frequency of salivary gland dysfunction in patients with chronic pancreatitis of various etiologies...
  82. ncbi [Fecal elastase-1 determination in the diagnosis of chronic pancreatitis]
    J Martinez
    Sección de Gastroenterología, Servicio de Medicina Interna, Servicio de Laboratorio, Hospital General Universitario de Alicante, Alicante, Spain
    Gastroenterol Hepatol 25:377-82. 2002
    ..I (14 patients with confirmed chronic pancreatitis); group II (5 patients with recurrent episodes of acute alcoholic pancreatitis; group III (9 patients with non-pancreatic diarrhea); group IV (8 patients with other gastrointestinal ..
  83. ncbi [Genetic risk factors in pancreatic diseases--significance for general practice]
    Volker Keim
    Medizinische Klinik und Poliklinik II der Universität Leipzig
    Med Klin (Munich) 97:278-84. 2002
    ..In approximately 20-25% of the patients with chronic pancreatitis a mutation of one of these genes can be found...
  84. ncbi Early onset idiopathic chronic pancreatitis: Is there a role for endoscopic treatment?
    Armando Gabbrielli
    JOP 4:133-6. 2003
  85. ncbi [Pancreaticojejunal anastomosis. Indication, technique and results]
    C Gebhardt
    , Thorax und Endokrine Chirurgie,
    Zentralbl Chir 126:29-31. 2001
    ..The end-to-side mucosa-mucosa anastomosis offers the best results concerning postoperativ complications and mortality rates...
  86. ncbi [Changes in indicators of external and internal secretion of the pancreas during treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogs]
    L V Vinokurova
    Ter Arkh 75:48-50. 2003
    ..To study somatostatin (SS) content in patients with chronic pancreatitis (CP) and effects of sandostatin (a synthetic analogue of SS) on endo- and exocrine pancreatic functions in CP patients...
  87. ncbi Exocrine pancreatic function after alcoholic or biliary acute pancreatitis
    Marina Migliori
    Institute of Internal Medicine, University of Bologna, Sant Orsola Hospital, Bologna, Italy
    Pancreas 28:359-63. 2004
    ..The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreatitis...
  88. ncbi Perforation of a pancreatic pseudocyst induced by abdominal sonography
    K Ocran
    Medizinische Klinik, Gastroenterologie, Hepatologie und Endokrinologie, Charité Universitätsmedizin Berlin Campus Mitte, Berlin, Germany
    Z Gastroenterol 42:243-6. 2004
    ..Although it cannot be advised as a treatment measure for a pseudocyst, regression of a pseudocyst due to emptying into the gastrointestinal tract has to be expected...
  89. ncbi Major pancreatic resections for chronic pancreatitis
    D M Proca
    Department of Pathology, Ohio State University, 410 W 10th Ave, Columbus, OH 43210, USA
    Arch Pathol Lab Med 125:1051-4. 2001
    ..pain was present in 25 (57%) of the 44 patients, and pain was encountered more frequently in patients with alcoholic pancreatitis (67%) versus other etiologies (52%), and in those who underwent Whipple/Beger or total resections (68%) ..
  90. ncbi Idiopathic tumefactive chronic pancreatitis: clinical profile, histology, and natural history after resection
    Dhiraj Yadav
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 1:129-35. 2003
    ..Little is known about subjects with idiopathic tumefactive chronic pancreatitis (TCP), that is, chronic pancreatitis whose clinical presentation, usually with a mass or obstructive jaundice, suggests cancer...
  91. ncbi [Implication of cytokines and role of biliary-pancreatic reflux in mechanisms of exacerbation and chronicity of recurrent pancreatitis]
    E N Zhukova
    Ter Arkh 76:11-4. 2004
    ....
  92. ncbi Does acute alcoholic pancreatitis exist with preexisting chronic pancreatitis?
    Robert Brunner
    J Clin Gastroenterol 38:201-2. 2004
  93. ncbi Calcifying obstructive pancreatitis: a study of intraductal papillary mucinous neoplasm associated with pancreatic calcification
    Mauricio Zapiach
    Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 2:57-63. 2004
    ..The aim of this study is to describe the profile of IPMN associated with calcification and gain insights into the pathogenesis of calcification in IPMN...
  94. ncbi Different CFTR mutational spectrum in alcoholic and idiopathic chronic pancreatitis?
    Teresa Casals
    Medical and Molecular Genetics Center IRO, Hospital DIR, Barcelona, Spain
    Pancreas 28:374-9. 2004
    ..We have therefore investigated the role of the CFTR gene in a cohort of 68 CP patients...
  95. ncbi Endoscopic management of pancreatic pseudocyst: a long-term follow-up
    S S Sharma
    Department of Gastroenterology, SMS Medical College, Jaipur, India
    Endoscopy 34:203-7. 2002
    ..The present study was undertaken to investigate the long-term outcome of endoscopic management of pancreatic pseudocyst with a minimum follow-up of 2 years...
  96. ncbi Immunocytes and activated stellate cells in pancreatic fibrogenesis
    Kaz Jaskiewicz
    Department of Pathology, University Medical School of Gdansk, Gdansk, Poland
    Pancreas 26:239-42. 2003
    ..and activated stellate cells in chronic pancreatitis, which was categorized into three groups: chronic alcoholic pancreatitis (AP), chronic idiopathic pancreatitis (IP), and chronic pancreatitis in the presence of pancreatic cancer (..
  97. ncbi IgG4-related sclerosing disease incorporating sclerosing pancreatitis, cholangitis, sialadenitis and retroperitoneal fibrosis with lymphadenopathy
    T Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Pancreatology 6:132-7. 2006
    ..Autoimmune pancreatitis is usually associated with elevated serum IgG4 concentrations, and sometimes with sclerosing cholangitis and Sjögren's syndrome. This study aimed to elucidate the proposed entity of IgG4-related sclerosing disease...
  98. pmc Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells
    Richard Hu
    Department of Veterans Affairs University of California, Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, Calif 90073, USA
    Pancreatology 7:332-40. 2007
    Activated stellate cells are considered the principal mediators of chronic alcoholic pancreatitis/fibrosis. However the mechanisms of alcohol action on pancreatic stellate cells (PaSCs) are poorly understood...
  99. ncbi Effect of native somatostatin on Sphincter of Oddi motility in patients with acute recurrent pancreatitis. A pilot study with Ultrasound-Secretin test
    V Di Francesco
    Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Dig Liver Dis 38:268-71. 2006
    ..Sphincter of Oddi inhibition was demonstrated at manometry in patients in the acute phase of alcoholic pancreatitis. Other investigators showed marked somatostatin-induced impairment of bile flow by hepato-biliary ..
  100. ncbi Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    Nils Homann
    Department of Medicine I, University of Lubeck, Germany
    Int J Cancer 118:1998-2002. 2006
    ..esophageal (n=123), head and neck (n=84) and hepatocellular cancer (n=86) as well as in patients with alcoholic pancreatitis (n=117), alcoholic liver cirrhosis (n=217), combined liver cirrhosis and pancreatitis (n=17) and in ..
  101. ncbi A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis
    Satoru Naruse
    Department of Internal Medicine, Nagoya University Graduate School of Medicine and Nagoya Institute of Technology, Nagoya, Japan
    Pancreas 28:e80-5. 2004
    ..We developed a simple method for measuring finger sweat chloride concentration to test whether CFTR dysfunction underlies chronic pancreatitis in Japan where cystic fibrosis (CF) is rare...

Research Grants93

  1. Hypoxia and free radicals in alcoholic pancreatitis
    Gavin Arteel; Fiscal Year: 2005
    ..damage will be blunted by these treatments, suggesting a role of endotoxin and macrophages in chronic alcoholic pancreatitis. Next, the hypothesis that free radicals play a causative role in chronic alcoholic pancreatitis will be ..
  2. Role of trypsinogen sulfation in alcoholic pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2006
    The main objective of this exploratory grant is to investigate the hypothesis that alcoholic pancreatitis is caused by premature intrapancreatic trypsinogen activation, as a result of altered post-translational modification of ..
  3. The Effect of Alcohol on NADPH oxidase structure in pancreatic stellate cells
    Kym Faull; Fiscal Year: 2007
    ..Because of these limitations and the importance of this system in alcoholic pancreatitis, we propose to identify the components of the NADPH oxidase complex from pancreatic stellate cells by ..
  4. Plasminogen System and Alcoholic Pancreatitis
    Aurelia Lugea; Fiscal Year: 2007
    ..alterations in the plg system are an integral part of the mechanisms underlying fibrogenesis in alcoholic pancreatitis. The specific aims of this proposal are to elucidate the role and regulation of the pancreatic plg system ..
  5. North American Pancreatitis Study 2 (NAPS2)
    David Whitcomb; Fiscal Year: 2006
    ..The results of these studies may result in the development new diagnostic tools that can be applied at the onset of symptoms, and rational therapy to prevent the development of those pancreatic diseases that we cannot currently cure. ..
  6. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David Whitcomb; Fiscal Year: 2009
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  7. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  8. NAPS2-AS: Race Dependent Risk for Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ....
  9. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David Whitcomb; Fiscal Year: 2009
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  10. Digestive Diseases Training Program
    David Whitcomb; Fiscal Year: 2007
    ..Postdoctoral graduates will be prepared to compete for independent funding and entry-level faculty positions in academic medicine ..
  11. Alcohol and the Exocrine Pancreas ER Stress Responses
    Stephen Pandol; Fiscal Year: 2007
    ..The results deriving from this project will allow us to pursue further projects on integrating the effects of ethanol on the UPR to the pathological responses of pancreatitis due to ethanol as well as provide. ..
  12. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2007
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  13. THE INFLAMMATORY RESPONSE OF THE PANCREATIC ACINAR CELL
    Stephen Pandol; Fiscal Year: 2006
    ..The results of the experiments described in the present application will allow us to propose how CCK, together with a cytokine modulating its effects, acts on the pancreatic acinar cell to cause experimental pancreatitis. ..
  14. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2002
    ..Answering this question may provide insight into the pathophysiology of acute and chronic pancreatitis and identify targets for new therapies, and help identify individuals at risk through genetic testing. ..
  15. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
  16. ETHANOL OXIDATION EFFECTS ON EGF SIGNAL TRANSDUCTION
    Dahn Clemens; Fiscal Year: 2001
    ....
  17. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2007
    ....
  18. Apoptosis and Necrosis in Pancreatitis
    Anna Gukovskaya; Fiscal Year: 2006
    ..abstract_text> ..
  19. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ....
  20. Apoptosis and Necrosis in Pancreatitis
    Anna Gukovskaya; Fiscal Year: 2009
    ..Our hypothesis proposes a mechanism for this pathological process and, further, links it to pancreatic cell death. ..
  21. Effects of Ethanol on Pancreas Regeneration
    Dahn Clemens; Fiscal Year: 2007
    ..In preliminary studies, using a murine model of alcoholic pancreatitis that combines ethanol feeding and pancreatic damage induced by coxsackievirus infection, we have ..
  22. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2010
    ....
  23. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  24. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  25. MECHANISM OF ETHANOL INDUCED IMPAIRMENTS IN IMMUNITY
    THOMAS JERRELLS; Fiscal Year: 2002
    ..By using the various infectious model systems in place in this laboratory the ETOH-mediated effects on the subsets of helper T cells (TH-1 and TH-2) will also be defined. ..
  26. IMMUNE RESPONSES AND ACHOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2002
    ..The proposed research will also define the specific cells that initiate or mediate liver damage as well as the role of the inflammatory response and inflammatory cytokines in these models of experimental ALD. ..
  27. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2007
    ..abstract_text> ..
  28. Susceptibility mechanism in alcoholic pancreatitis
    Herbert Gaisano; Fiscal Year: 2007
    ..Significance: These actions of alcohol on pancreatic acinar PM-Munc18c may be the 'sentinel' event that initiates the role of alcohol in pancreatic injury, and which could be therapeutically targeted. ..
  29. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 1999
    ..Results from these experiments will improve the understanding of the immunomodulatory effects of acute, moderate alcohol use in humans. ..