liver cirrhosis

Summary

Summary: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Top Publications

  1. pmc Liver fibrosis
    Ramon Bataller
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    J Clin Invest 115:209-18. 2005
  2. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
  3. ncbi The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    Joseph F Perz
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral Hepatitis, Epidemiology Branch, Atlanta, GA 30333, USA
    J Hepatol 45:529-38. 2006
  4. pmc Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Physiol Rev 88:125-72. 2008
  5. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
  6. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
  7. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
  8. pmc Mechanisms of hepatic fibrogenesis
    Ursula E Lee
    Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Ave, Room 11 76, New York, NY 10029, USA
    Best Pract Res Clin Gastroenterol 25:195-206. 2011
  9. ncbi Lamivudine for patients with chronic hepatitis B and advanced liver disease
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    N Engl J Med 351:1521-31. 2004
  10. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003

Detail Information

Publications355 found, 100 shown here

  1. pmc Liver fibrosis
    Ramon Bataller
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    J Clin Invest 115:209-18. 2005
    ..This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies...
  2. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
    ..Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease...
  3. ncbi The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    Joseph F Perz
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral Hepatitis, Epidemiology Branch, Atlanta, GA 30333, USA
    J Hepatol 45:529-38. 2006
    ..Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are well-recognized risk factors for cirrhosis and liver cancer, but estimates of their contributions to worldwide disease burden have been lacking...
  4. pmc Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Physiol Rev 88:125-72. 2008
    ..As interest in this cell type intensifies, more surprises and mysteries are sure to unfold that will ultimately benefit our understanding of liver physiology and the diagnosis and treatment of liver disease...
  5. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
    ..A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease...
  6. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  7. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    ..Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities (eg, obesity, diabetes) in the HCC risk in cirrhosis...
  8. pmc Mechanisms of hepatic fibrogenesis
    Ursula E Lee
    Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Ave, Room 11 76, New York, NY 10029, USA
    Best Pract Res Clin Gastroenterol 25:195-206. 2011
    ..Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease...
  9. ncbi Lamivudine for patients with chronic hepatitis B and advanced liver disease
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    N Engl J Med 351:1521-31. 2004
    ..The effectiveness of antiviral therapy in preventing disease progression in patients with chronic hepatitis B and advanced fibrosis or cirrhosis is unknown...
  10. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients...
  11. ncbi Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
    Laurent Sandrin
    Echosens, Paris, France
    Ultrasound Med Biol 29:1705-13. 2003
    ..88 and 0.99 for the diagnosis of patients with significant fibrosis (>/= F2) and with cirrhosis ( = F4), respectively. The Fibroscan is a noninvasive, painless, rapid and objective method to quantify liver fibrosis...
  12. pmc Liver cirrhosis
    Detlef Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 371:838-51. 2008
    ..This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments...
  13. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
    ....
  14. pmc Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
    L Xu
    Division of Liver Diseases, Department of Medicine, Box 1123, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11 70C, New York, NY10029, USA
    Gut 54:142-51. 2005
    ..We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells...
  15. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  16. pmc Macrophages: master regulators of inflammation and fibrosis
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Liver Dis 30:245-57. 2010
    ..Although collagen-secreting myofibroblasts once were thought of as the master "producers" of fibrosis, this review will illustrate how macrophages function as the master "regulators" of fibrosis...
  17. ncbi Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    Uchenna H Iloeje
    Global Epidemiology and Outcomes Research, Pharmaceutical Research Institute, Bristol Myers Squibb Company, Wallingford, Connecticut
    Gastroenterology 130:678-86. 2006
    ..Cirrhosis develops as a result of hepatic inflammation and subsequent fibrosis in chronic hepatitis B infection. We report on the relationship between hepatitis B viremia and progression to cirrhosis in chronic hepatitis B infection...
  18. ncbi Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    ..Sampling variability becomes a major limitation when using more accurate methods such as automated image analysis...
  19. ncbi Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  20. ncbi The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    A M Elsharkawy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Level D, South Academic Block, Southampton, SO16 6YD, UK
    Apoptosis 10:927-39. 2005
    ..The potential for known pharmacological agents such as gliotoxin, sulfasalazine, benzodiazepine ligands, curcumin and tanshinone I to induce HSC apoptosis and therefore to be used therapeutically will be explored...
  21. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    ..Several recent studies have highlighted that cardiovascular disease is the single most important cause of morbidity and mortality in this patient population...
  22. ncbi Evolving challenges in hepatic fibrosis
    Scott L Friedman
    Mount Sinai School of Medicine, Division of Liver Diseases, New York, NY 10029, USA
    Nat Rev Gastroenterol Hepatol 7:425-36. 2010
    ..As a result, focus is shifting towards overcoming key translational challenges in order to accelerate the development of new therapies for patients with chronic liver disease...
  23. ncbi Roles of TGF-beta in hepatic fibrosis
    Axel M Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    Front Biosci 7:d793-807. 2002
    ....
  24. ncbi IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC
    Carlo Fabris
    Internal Medicine, DPMSC, University of Udine, Italy
    J Hepatol 54:716-22. 2011
    ..We verified whether this association also translates into a different genotype distribution at the end of the disease trajectory...
  25. ncbi Liver fibrosis -- from bench to bedside
    Scott L Friedman
    Division of Liver Diseases, PO Box 1123, Mount Sinai School of Medicine, 1425 Madison Ave Room 1170F, New York, NY 10029, USA
    J Hepatol 38:S38-53. 2003
  26. ncbi Non-invasive evaluation of liver fibrosis using transient elastography
    Laurent Castera
    Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
    J Hepatol 48:835-47. 2008
    ..Guidelines are needed for the use of TE in clinical practice...
  27. pmc Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
    Jinmai Jiang
    College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 14:419-27. 2008
    ..MicroRNA (miRNA) is a new class of small, noncoding RNA. The purpose of this study was to determine if miRNAs are differentially expressed in hepatocellular carcinoma (HCC)...
  28. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  29. pmc Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    John P Iredale
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:539-48. 2007
    ..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ...
  30. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
    ..Under the current liver-transplantation policy, donor organs are offered to patients with the highest risk of death...
  31. ncbi Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
    Mireen Friedrich-Rust
    Department of Internal Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 134:960-74. 2008
    ..A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy...
  32. ncbi Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
    Karlin Raja Karlmark
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    Hepatology 50:261-74. 2009
    ..Intrahepatic CD11b(+)F4/80(+)Gr1(+) monocyte-derived macrophages purified from CCl(4)-treated animals, but not naïve bone marrow monocytes or control lymphocytes, directly activate HSCs in a TGF-beta-dependent manner in vitro...
  33. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  34. ncbi Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    A M Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, D 52074 Aachen, Germany
    J Cell Mol Med 10:76-99. 2006
    ....
  35. pmc Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
    M Pinzani
    Istituto di Medicina Interna Centro Interuniversitario di Fisiopatologia Epatica, Universita di Firenze, Italy
    Am J Pathol 148:785-800. 1996
    ....
  36. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  37. ncbi Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
    Qing Liu
    Artificial Liver Treatment and Training Center, Beijing Youan Hospital and Capital University of Medical Sciences, Beijing, China
    Hepatology 39:1441-9. 2004
    ..In conclusion, treatment with synbiotics or fermentable fiber is an alternative to lactulose for the management of MHE in patients with cirrhosis...
  38. ncbi The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    Mustafa S Ascha
    Department of Gastroenterology and Hepatology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 51:1972-8. 2010
    ..Compared with nondrinkers, patients who reported any regular alcohol consumption were at greater risk for HCC development (hazard ratio: 3.6; P25, P75: 1.5, 8.3)...
  39. ncbi Characterization of fecal microbial communities in patients with liver cirrhosis
    Yanfei Chen
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, PR China
    Hepatology 54:562-72. 2011
    b>Liver cirrhosis is the pathologic end stage of chronic liver disease. Increasing evidence suggests that gut flora is implicated in the pathogenesis of liver cirrhosis complications...
  40. ncbi Noninvasive methods to assess liver disease in patients with hepatitis B or C
    Laurent Castera
    Department of Hepatology, Hopital Beaujon, Assistance Publique Hopitaux de Paris, INSERM U773 CRB3, Universite Denis Diderot Paris 7, Clichy, France
    Gastroenterology 142:1293-1302.e4. 2012
    ..We review the advantages and limitations of the noninvasive methods used to manage patients with chronic viral hepatitis B or C infection...
  41. ncbi Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    Yong Han Paik
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Hepatology 37:1043-55. 2003
    ..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury...
  42. pmc Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 7:e36676. 2012
    ..This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis...
  43. ncbi Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques
    Frank Tacke
    Department of Medicine III RWTH, University Hospital Aachen, Aachen, Germany
    Expert Rev Gastroenterol Hepatol 6:67-80. 2012
    ..Novel isolation techniques, specifically HSC sorting by FACS via autofluorescence and antibodies, will provide us with further opportunities to advance our understanding of HSC biology in health and disease...
  44. ncbi Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
    Bart J Veldt
    Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 147:677-84. 2007
    ..Clinical outcomes of chronic hepatitis C infection in patients with advanced fibrosis include liver failure, hepatocellular carcinoma, and death...
  45. ncbi Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
    Tatiana Kisseleva
    Department of Medicine, Columbia University, New York, USA
    J Gastroenterol Hepatol 22:S73-8. 2007
    ..This review is focused on recent progress in the study of the pathogenesis of liver fibrosis...
  46. ncbi Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies
    Gennaro D'Amico
    Gastroenterology Unit, Ospedale Cervello and University of Palermo, Italy
    J Hepatol 44:217-31. 2006
  47. ncbi Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    Sara Aleffi
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 42:1339-48. 2005
    ..In conclusion, ObR activation in HSCs leads to increased expression of proinflammatory and proangiogenic cytokines, indicating a complex role for leptin in the regulation of the liver wound-healing response...
  48. ncbi Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors
    Giovanna Fattovich
    Department of Surgical and Gastroenterological Sciences, University of Verona, Piazzale L A Scuro, 10, Verona 37134, Italy
    J Hepatol 48:335-52. 2008
    ..There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B...
  49. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology...
  50. pmc The prognosis of liver cirrhosis in recent years in Korea
    Young Sun Kim
    Institution of Digestive Disease and Nutrition, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 18:833-41. 2003
    ..These data suggest that the mortality of major complications of liver cirrhosis has considerably decreased during the last two decades, while there was no remarkable improvement in long-..
  51. ncbi Chemokines in liver inflammation and fibrosis
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
    Semin Liver Dis 30:215-25. 2010
    ..Here, we summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression...
  52. ncbi Serum markers detect the presence of liver fibrosis: a cohort study
    William M C Rosenberg
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
    Gastroenterology 127:1704-13. 2004
    ..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...
  53. pmc Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
    Mirella Fraquelli
    Second Division of Gastroenterology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Gut 56:968-73. 2007
    ..This study investigated these aspects...
  54. pmc Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
    J Foucher
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Gut 55:403-8. 2006
    ..5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease...
  55. ncbi Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
    ..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
  56. ncbi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    ..07; 95% CI, 1.02-1.14), and diabetes (OR, 1.8; 95% CI, 1.4-2.3) in the overall series, serum ferritin and diabetes in those with increased ALT, and only HOMA-IR (OR, 1.97; 95% CI, 1.2-3.7) in patients with normal ALT...
  57. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002
    ..In conclusion, a combination of easily accessible variables accurately predicts the absence of significant fibrosis and might render liver biopsy unnecessary in more than one third of patients with chronic hepatitis C...
  58. ncbi Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial
    Pedram Kharaziha
    Urology and Nephrology Research Center UNRC, Karolinska Institutet, Stockholm, Sweden, Karolinska University Hospital Solna, Sweden
    Eur J Gastroenterol Hepatol 21:1199-205. 2009
    ..End-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment...
  59. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  60. ncbi Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study
    Alain Luciani
    INSERM Unite U 841, Equipe 17, Molecular Mechanisms of Liver Fibrosis, Creteil, France
    Radiology 249:891-9. 2008
    ....
  61. ncbi Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data
    David A Leon
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 367:52-6. 2006
    ..Total recorded alcohol consumption in Britain doubled between 1960 and 2002, giving rise to a need to examine and assess cirrhosis mortality trends...
  62. ncbi Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    Suguru Oyagi
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871 Japan
    J Hepatol 44:742-8. 2006
    ..Here, we transplanted bone marrow-derived mesenchymal cells (BMMCs) to test their effect in liver-injured rats...
  63. ncbi Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus
    Juan Macias
    Infectious Diseases Unit, Hospital Universitario de Valme, Seville, Spain
    Hepatology 50:1056-63. 2009
    ..61 [0.39-0.93], P = 0.03), moderate-to-severe lobular necroinflammation (1.77 [1.16-2.7], P = 0.009), time between biopsies (1.11 [1.08-1.2], P = 0.01), and end of treatment response to anti-HCV therapy (0.41 [0.19-0.88], P = 0.02)...
  64. ncbi FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest
    Anais Vallet-Pichard
    Universite Paris Descartes, Paris, France
    Hepatology 46:32-6. 2007
    ..45 or >3.25 (kappa = 0.561, P < 0.01). A FIB-4 value <1.45 or >3.25 (64.6% of the cases) was concordant with FibroTest results in 92.1% and 76%, respectively...
  65. ncbi Early use of TIPS in patients with cirrhosis and variceal bleeding
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, University of Barcelona, Barcelona, Spain
    N Engl J Med 362:2370-9. 2010
    ..This study evaluated the earlier use of TIPS in such patients...
  66. ncbi Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
    ..This finding introduces a new concept for the therapy of liver fibrosis...
  67. ncbi Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension?
    Dominique Thabut
    Gastroenterology Research Unit, Advanced Liver Disease Study Group, Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN, USA
    J Hepatol 53:976-80. 2010
    ....
  68. ncbi Chemokines in liver inflammation and fibrosis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Italy
    Front Biosci 7:d1899-914. 2002
    ..These data indicate that chemokines in the liver may modulate the progression of liver fibrosis through actions on hepatic stellate cells...
  69. ncbi Treatment of chronic hepatitis C in Asia: when East meets West
    Ming Lung Yu
    Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Gastroenterol Hepatol 24:336-45. 2009
    ..Given the lack of an effective vaccine, optimal treatment of chronic HCV infection is now perceived as a 'must' in terms of public health strategies, as well as of the clinical setting for individual patients...
  70. ncbi Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..001). Five HCCs, all from the MS group, developed on a preexisting liver cell adenoma, with three of them showing typical histological features of telangiectatic adenoma...
  71. ncbi Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Gastroenterology 123:1084-9. 2002
    ..The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients...
  72. ncbi Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus
    Bart J Veldt
    Erasmus MC University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
    Hepatology 47:1856-62. 2008
    ..013). Multivariate Cox regression analysis of patients with Ishak 6 cirrhosis showed that diabetes mellitus was independently associated with the development of HCC (hazard ratio, 3.28; 95% CI, 1.35-7.97; P = 0.009)...
  73. ncbi The epidemiology of nonalcoholic fatty liver disease in adults
    Jeanne M Clark
    Department of Medicine and Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Gastroenterol 40:S5-10. 2006
    ..More prospective studies are needed to determine the true risk factors for the development and progression of NAFLD to help identify patients at highest risk who might benefit from treatment trials...
  74. ncbi Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C
    Marianne Ziol
    UPRES EA 3406, University of Paris 13, Bobigny, France
    Hepatology 41:48-54. 2005
    ..In conclusion, noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C...
  75. ncbi Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Gastroenterology 121:91-100. 2001
    ..Predicting advanced or progressive disease may help in selecting patients for liver biopsy and assist the development of therapeutic options...
  76. pmc Anti-fibrogenic strategies and the regression of fibrosis
    Tatiana Kisseleva
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0602, USA
    Best Pract Res Clin Gastroenterol 25:305-17. 2011
    ..Here we discuss the origin of activated myofibroblasts and different aspects of their activation, differentiation and potential inactivation during regression of liver fibrosis...
  77. ncbi Projecting future complications of chronic hepatitis C in the United States
    Gary L Davis
    Division of Hepatology, Baylor Regional Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 9:331-8. 2003
    ..These data emphasize the need for greater access to transplantation by expansion of the donor pool, increasing use of split livers and living donors, and novel options such as xenotransplantation...
  78. ncbi Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation
    Alexander Dechene
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Hepatology 52:1008-16. 2010
    ..This was paralleled by collagen deposition, elevated alpha-SMA expression, and higher LS (25.6 +/- 3.0 kPa). ALF was associated with ductular progenitor proliferation...
  79. ncbi Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Japan
    Ann Intern Med 131:174-81. 1999
    ..Previous studies on the effect of interferon therapy on the incidence of hepatocellular carcinoma have not sufficiently assessed degree of liver fibrosis, a major risk factor for hepatocellular carcinoma...
  80. ncbi Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Insitute, and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, New South Wales, Australia
    Gastroenterology 125:1695-704. 2003
    ..Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection...
  81. pmc Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen, Germany
    J Clin Invest 120:4129-40. 2010
    ..Our results define a successful therapeutic approach to reduce experimental liver fibrosis by antagonizing Ccl5 receptors...
  82. ncbi Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    Gastroenterology 131:1743-51. 2006
    ..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks...
  83. ncbi The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..By applying this model, a liver biopsy would have been avoided in 549 (75%) of the 733 patients, with correct prediction in 496 (90%)...
  84. ncbi Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
    J Mann
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
    Cell Death Differ 14:275-85. 2007
    ..We conclude that MeCP2 and DNA methylation exert epigenetic control over hepatic wound healing and fibrogenesis...
  85. pmc Non-invasive markers for hepatic fibrosis
    Ancha Baranova
    Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA
    BMC Gastroenterol 11:91. 2011
    ..This review provides a systematic overview of these techniques, as well as both direct and indirect biomarkers based approaches used to stage fibrosis and covers recent developments in this rapidly advancing area...
  86. ncbi Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    Feng Jiang
    Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA
    J Hepatol 45:401-9. 2006
    ..To understand molecular mechanisms of HSCs activation a comprehensive comparison of gene expression between quiescent and activated HSCs is needed...
  87. ncbi Acute viral hepatitis increases liver stiffness values measured by transient elastography
    Umberto Arena
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi Firenze, Italy
    Hepatology 47:380-4. 2008
    ..LSM does not represent a reliable instrument to detect the presence of advanced fibrosis and cirrhosis in patients presenting with a clinical picture of acute hepatitis...
  88. pmc Gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with CCl4-induced fibrosis
    Isabel Gómez-Hurtado
    Unidad Hepática, Hospital General Universitario, Alicante, Spain
    PLoS ONE 6:e23037. 2011
    ..Gut is the major source of endogenous bacteria causing infections in advanced cirrhosis. Intestinal barrier dysfunction has been described in cirrhosis and account for an increased bacterial translocation rate...
  89. ncbi A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen
    N Barascuk
    Nordic Bioscience A S, Herlev, Denmark
    Clin Biochem 43:899-904. 2010
    ..Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for quantification of MMP-9 derived collagen type III (CO3) degradation...
  90. ncbi Pathogenesis of liver fibrosis
    Virginia Hernandez-Gea
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pathol 6:425-56. 2011
    ..As pathways of fibrogenesis are increasingly clarified, the key challenge will be translating new advances into the development of antifibrotic therapies for patients with chronic liver disease...
  91. ncbi Liver fibrosis: a dynamic and potentially reversible process
    Davide Povero
    Department of Experimental Medicine and Oncology, University of Torino, Italy
    Histol Histopathol 25:1075-91. 2010
    ..representing a major driving force for progressive accumulation of ECM components, eventually leading to liver cirrhosis. Cirrhosis is characterized by fibrous septa dividing the hepatic parenchyma into regenerative pseudo-lobules,..
  92. ncbi Hepatic Encephalopathy
    A T Blei
    Department of Medicine, Lakeside VA Medical Center and Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 96:1968-76. 2001
    ..In patients with significant deficits or complaints, a therapeutic program based on dietary manipulations and/or nonabsorbable disaccharides may be tried. Benzodiazepines should not be used for patients with sleep difficulties...
  93. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
    ..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
  94. ncbi Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B
    S U Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 32:498-505. 2010
    ..Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan...
  95. ncbi Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease
    S H Caldwell
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA
    Hepatology 29:664-9. 1999
    ..Although there is some diversity that indicates more than one cause, our findings suggest that NASH plays an under-recognized role in many patients with cryptogenic cirrhosis, most of whom are older, type 2 diabetic and obese females...
  96. ncbi Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    Hashem B El-Serag
    Section of Gastroenterology, Houston Departmentof Veterans Affais Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 126:460-8. 2004
    ..An association between diabetes and chronic liver disease has been reported. However, the temporal relationship between these conditions remains unknown...
  97. ncbi Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection
    Marija Zeremski
    Division of Gastroenterology and Hepatology and Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, USA
    J Infect Dis 200:1774-80. 2009
    ..We evaluated the potential of peripheral chemokine levels to discriminate among patients with chronic HCV infection who had different stages of fibrosis...
  98. ncbi Bacterial translocation (BT) in cirrhosis
    Reiner Wiest
    Department of Internal Medicine I, University of Regensburg Hospital Franz Josef Strauss Allee, Regensburg, Germany
    Hepatology 41:422-33. 2005
    ..Future research in the field of BT in cirrhosis will allow the development of new therapeutic targets in the prevention of infections and other complications of cirrhosis...
  99. ncbi Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 51:1209-17. 2010
    ..12-2.04), and fibrosis stage >1 (OR = 1.5, 95% CI = 1.09-2.12), independent of age, body mass index, and diabetes. Adiponutrin genotype demonstrated a dose effect with heterozygote risk intermediate between CC and GG homozygotes...
  100. pmc Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection
    Netanya G Sandler
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 141:1220-30, 1230.e1-3. 2011
    ..We investigated whether the extent and progression of liver disease in patients with chronic HBV or HCV infection are associated with microbial translocation and subsequent activation of monocytes...
  101. ncbi Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies
    Stefanie Hemmann
    Department of Medicine II, Gastroenterology, University Hospital Giessen and Marburg GmbH, Paul Meimberg Str 5, 35392 Giessen, Germany
    J Hepatol 46:955-75. 2007
    ..The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table...

Research Grants68

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..NASH), a serious condition in which inflammation kills liver cells, ultimately culminating in liver cirrhosis, portal hypertension, and liver failure...
  2. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..Thus, the preliminary studies identify TAL deficiency as a novel cause of liver cirrhosis and HCC which are preventable by lifelong supplementation of the potent antioxidant NAC...
  3. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..modulator of liver tumor cell growth, AhR ligand, and is elevated in carriers of BVR mutation with end-stage liver cirrhosis. Indeed, a compromised BVR activity causes "green jaundice", which is nearly always fatal...
  4. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..transmitted diseases;late stage breast cancer diagnosis;breast, cervical, colorectal, liver, and lung cancer;liver cirrhosis;cardiovascular diseases;tobacco-related diseases;and other diseases caused by exposure to carcinogens, ..
  5. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  6. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..Most infections become chronic often leading to liver cirrhosis and cancer. In the United States 10,000 to 20,000 deaths a year are caused by chronic HCV infection...
  7. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    ..Millions of people each year die from liver cirrhosis. Liver cancer is among the top five most prevalent tumor types worldwide, with an estimated 1 million deaths ..
  8. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..especially the elderly, in the young with post-traumatic injury, and in patients with heart failure or liver cirrhosis, and this has an adverse effect on morbidity and mortality...
  9. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..liver diseases will supervise the epidemiological and clinical components of hepatitis C virus (HCV) and liver cirrhosis. I propose two developmental projects that will further my career progress...
  10. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    ..In many cases HCV infection becomes chronic, which can progress to liver cirrhosis and hepatocellular carcinoma...
  11. Insulin resistance in the pathogenesis of NASH
    SONIA MICHAEL NAJJAR; Fiscal Year: 2010
    ..Because NASH frequently progresses to liver cirrhosis, and is becoming the leading cause of liver transplant in the US, it is imperative to understand its ..
  12. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..are likely to provide therapeutic benefit to patients in a wide range of pathological conditions, such as liver cirrhosis, liver fibrosis, renal failure, wound healing, and chemotherapy-induced liver or renal damage...
  13. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin E Behrns; Fiscal Year: 2010
    b>Liver cirrhosis has an increasing incidence and prevalence in the United States and is closely associated with the development of hepatocellular carcinoma, which has a dismal long-term prognosis...
  14. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis
    Athan Kuliopulos; Fiscal Year: 2013
    ..and inflammatory cells which controls inflammatory and fibrotic processes that lead towards severe NASH and liver cirrhosis. The cell-penetrating, lipidated PAR2 inhibitor PZ-235 was developed using pepducin technology and offers a ..
  15. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    ..Dysregulation of bile acid metabolism causes cholestatic liver injury and contributes to liver cirrhosis, steatosis, dyslipidemia, diabetes, obesity, and atherosclerosis...
  16. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..Chronic inflammation resulting in liver cirrhosis is the most important risk factor for the development of HCC, hence changes in the stromal microenvironment ..
  17. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    John Y L Chiang; Fiscal Year: 2013
    ..Dysregulation of bile acid metabolism causes cholestatic liver injury and contributes to liver cirrhosis, steatosis, dyslipidemia, diabetes, obesity, and atherosclerosis...
  18. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..fatty liver disease and chronic hepatitis C worldwide, it is expected that the health care impact and cost of liver cirrhosis will dramatically increase in the next 10-20 years...
  19. Novel prognostic microRNA biomarkers for primary sclerosing cholangitis
    Kris Kowdley; Fiscal Year: 2013
    ..serum miRNA are elevated in patients with a variety of liver diseases and pathologies including HCC, HBV and liver cirrhosis. Therefore serum miRNAs represent a new type of diagnostic and prognostic biomarker for several liver ..
  20. Synergistic actions by multiple Toll-like receptors in alcoholic liver disease
    Ekihiro Seki; Fiscal Year: 2013
    ..only LPS, but also bacterial DNA levels in blood and ascites are elevated in patients with alcoholic-induced liver cirrhosis. Bacterial DNA is recognized by TLR9 that is widely expressed in immune cells including Kupffer cells, ..
  21. Serum Biomarkers Associated With Phenotypic Expression of Hemochromatosis.
    Kris Kowdley; Fiscal Year: 2013
    ..serum miRNA are elevated in patients with a variety of liver diseases and pathologies including HCC, HBV and liver cirrhosis, therefore serum miRNAs represent a new type of diagnostic and prognostic biomarker, and potential ..
  22. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    Elizabeth K Speliotes; Fiscal Year: 2012
    ..of the epidemic worldwide increase in obesity, many people have fat deposited in their liver that can lead to liver cirrhosis and liver failure;nevertheless, little is known about the genetic epidemiology or metabolic consequences of ..
  23. Chemical Biology of Nuclear Receptor Action in the Macrophage
    Willa A Hsueh; Fiscal Year: 2010
    ..to additional pathologies, including non-alcoholic steatohepatitis (NASH), the second most common cause of liver cirrhosis;Alzheimer's disease;cardiomyopathy;cancer;and others, many associated with or exacerbated by aging...
  24. DINUCLEOTIDE ISOMER AS A NOVEL ANTIVIRAL
    Radhakrishnan P Iyer; Fiscal Year: 2010
    ..Worldwide, more than 1 to 2 million deaths occur every year due to liver cirrhosis and liver cancer...
  25. The Role of Autophagy in Alcohol-Induced Liver Injury
    Wen Xing Ding; Fiscal Year: 2010
    ..Alcohol abuse and alcoholism accounts for approximately 50 % of all death induced by liver cirrhosis. However, the pathogenesis of alcoholic liver diseases (ALD) is not completely understood although recent ..
  26. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  27. Novel therapeutic for Alcoholic Liver Disease
    Bert Oehlen; Fiscal Year: 2009
    ..several known causes for the development of cirrhosis, but alcohol intake remains the most important cause of liver cirrhosis in Western countries...
  28. C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
    Mario Chojkier; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Excessive liver fibrosis can result in liver cirrhosis, which accounts for the significant complications and mortality among the population with chronic liver ..
  29. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..S., alcohol liver disease (ALD) affects more than 10 million people and accounts for 48% of liver cirrhosis-associated deaths...
  30. Arterial Remodeling in Chronic Liver Diseases
    Yasuko Iwakiri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In liver cirrhosis, chronic portal hypertension causes hemodynamic abnormalities and leads to thinning of the arterial wall in the splanchnic and systemic circulation...
  31. LDL Receptor Related Protein-1 in Metabolic and Cardiovascular Disease Modulation
    David Y Hui; Fiscal Year: 2013
    ..reduces HDL production, lowers plasma HDL-cholesterol levels, and promotes injury-induced steatohepatitis and liver cirrhosis. Taken together, these results indicate that LRP1 inactivation in adipose and liver promotes other metabolic ..
  32. Backbone Modified Peptide-nucleic Acids as Antiviral Agents Against Hepatitis C
    MIHAELA R MIHAILESCU; Fiscal Year: 2012
    ..50% of the patients and chronically HCV infected patients can develop serious health problems which include liver cirrhosis and hepatocellular carcinoma. Thus, there is an urgent need for the development of new therapeutic strategies...
  33. Mechanisms of RNA binding and remodeling proteins
    Kevin D Raney; Fiscal Year: 2012
    ..virus infection that can lead to liver fibrosis and, progressively, to severe and fatal diseases, including liver cirrhosis and liver cancer...
  34. A Genetic Screen for HCC Genes
    DAVID ANDREW LARGAESPADA; Fiscal Year: 2013
    ..will be used to find genes consistently mutated by transposon insertion with and without background liver cirrhosis. Candidate HCC genes will be tested for their ability to cause cancer by SB mediated gene transfer into ..
  35. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2012
    Abstract The hepatitis B virus (HBV) remains a global cause of chronic liver diseases, including liver cirrhosis and cancer. Current antiviral therapy for chronic hepatitis B is only partially effective...
  36. Characterization and Consequences of HCV Interaction with Host Lipoproteins
    MARGARET ADELE SCULL; Fiscal Year: 2012
    ..by applicant): Over 170 million people world-wide are infected with hepatitis C virus (HCV), a major cause of liver cirrhosis and hepatocellular carcinoma...
  37. Treatment for alcoholic liver disease
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Alcohol intake remains the most important cause of liver cirrhosis in Western countries...
  38. Genetic risk factors for alcoholic cirrhosis - genome-wide case-control study
    John B Whitfield; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alcoholic liver cirrhosis (ALC) remains a major cause of morbidity and mortality and is the most common cause of liver disease In the developed world...
  39. Phase I Clinical Study Using an Antifibrotic Drug
    Weizhong Cai; Fiscal Year: 2011
    ..use, virus infection (hepatitis B and C), iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  40. Post-Reductionist Protein Folding: Determining the In-cell Folding Energy Landsca
    Daniel N Hebert; Fiscal Year: 2013
    ..Misfolding of a number of these proteins results in diseases ranging from cystic fibrosis to liver cirrhosis. While full-length proteins can be studied in vitro using a myriad of biophysical techniques, thus allowing ..
  41. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca G Wells; Fiscal Year: 2013
    ..the pathological wound healing response to chronic liver injury from multiple causes and is the precursor to liver cirrhosis, a condition that results in significant morbidity and mortality in the United States and worldwide...
  42. Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
    Yujin Hoshida; Fiscal Year: 2013
    ..Our new and existing datasets, representing a global cirrhosis patient population, will be assembled as a public database that enables quick and easy clinical utility assessment of a user's prognostic molecular signatures. ..
  43. Role of FGF10 in liver organogenesis and alcohol-impaired regeneration
    KASPER SAONUN WANG; Fiscal Year: 2010
    ..This contributes to the development of liver cirrhosis. We postulate that the mechanism by which alcohol impairs liver regeneration may be due to impaired signaling ..
  44. Alliance of Glycobiologists for Detection of Cancer
    Radoslav Goldman; Fiscal Year: 2013
    ..Major re-distribution of protein N-glycoforms occurs at the premalignant stage of liver cirrhosis but our latest studies show that specific glycoforms of a glycopeptide of haptoglobin increase exclusively in ..
  45. The Molecular Mechanism of Antibody Neutralization of Hepatitis C Virus
    Michelle Sabo; Fiscal Year: 2013
    ..Chronic HCV infection is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Indeed, HCV is the leading cause of liver transplantation in the United States...
  46. Protective role of adenosine 2A receptor in NAFLD
    Chaodong Wu; Fiscal Year: 2013
    ..fatty liver disease (NAFLD) is one of the most common causes of terminal liver diseases including liver cirrhosis and hepatocellular carcinoma...
  47. Control of HBV replication at the step of core and P protein translation
    Jisu Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV), which causes liver cirrhosis and hepatocellular carcinoma, has a small, compact genome. The only transcript required for genome replication is the 3.5-kb pregenomic (pg) RNA...
  48. The Function of FcRn in Liver and the Role of N-Glycans
    Timothy T Kuo; Fiscal Year: 2010
    ..levels of IgG are commonly found in the serum and/or bile of autoimmune liver disease, viral hepatitis, liver cirrhosis, and cholelithiasis...
  49. HBV replication and carcinogenesis
    J H James Ou; Fiscal Year: 2013
    ..HBV) is a hepatotropic virus that can cause severe liver diseases including acute and chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC)...
  50. Hepatitis C Virus and Hepatocellular Carcinoma
    Srikanta Dash; Fiscal Year: 2013
    ..Patients who remain non-responders to IFN-[unreadable] /ribavirin are at a high risk of developing liver cirrhosis and cancer...
  51. The Molecular Basis of Serpin Function and Disfunction
    Patrick L Wintrode; Fiscal Year: 2011
    ..S. suffering from the severe form. This disorder can lead to both liver cirrhosis and emphysema. Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms...
  52. Alcohol-induced liver fibrosis:an in vitro model
    Raj M Lakshman; Fiscal Year: 2012
    ..Public Health Relevance: As alcohol-induced liver cirrhosis is among the leading causes of death in the U.S...
  53. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
    ..It is also elevated in the serum of patients with liver cirrhosis, cholestatic liver disease, alcoholism and other non-malignant liver diseases...
  54. One Enzyme for Two Distinct Metabolisms
    F Robert Tabita; Fiscal Year: 2013
    ..or reduced functioning of the methionine salvage pathway has consequences relative to cancer cell growth and liver cirrhosis. In addition, intermediates of this pathway have been shown to influence apoptotic processes, while analogs ..
  55. Phagocytosis and NOX2 in Liver Fibrogenesis
    Natalie J Torok; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Liver cirrhosis is a leading cause of morbidity and mortality worldwide...
  56. Post-translational Surveillance of Genome Expression
    Richard Sifers; Fiscal Year: 2009
    ..with a model in which an elevated ERManI concentration plays a protective role by delaying the onset of liver cirrhosis associated with the accumulation of aberrant alphal-antitrypsin PI Z polymers in the ER of liver hepatocytes...
  57. Development of Small Molecule Mimetics of hepatocyte Growth Factor (HGF)
    ANNE MUESCH; Fiscal Year: 2012
    ..HGF effectively alleviates the structural damage seen in liver cirrhosis, an end-stage liver disease that is frequently caused by Hepatitis C infection or long-term alcohol abuse...
  58. Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach
    David M Lubman; Fiscal Year: 2013
    ..b>Liver cirrhosis is the most important factor in the development of HCC...
  59. G-quadruplex in Translational Regulation and Cancer Therapy
    Hong Lu; Fiscal Year: 2013
    ..simultaneously treating liver cancer and improving liver function, because most liver cancer patients have liver cirrhosis. A group of liver-enriched transcription factors (TFs) are master regulators of liver development and liver ..
  60. Mechanisms of hepatitis C virus persistence
    Arash Grakoui; Fiscal Year: 2013
    ..infection in the liver of nearly 80% of those infected and in addition to causing hepatitis, may cause liver cirrhosis and hepatocellular carcinoma...
  61. Aberrantly secreted glycoproteins as markers of liver cancer
    Anand S Mehta; Fiscal Year: 2013
    ..we will examine the ability of our identifid biomarkers to differentiate patients with HCC from patients with liver cirrhosis in a cohort of 1500 patients...
  62. Hepatitis C virus and autophagic response
    J H James Ou; Fiscal Year: 2013
    ..Hepatitis C virus (HCV) is an important human pathogen that can cause severe liver diseases including liver cirrhosis and hepatocellular carcinoma...
  63. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary/Abstract: Liver cirrhosis is a chronic and degenerative disease that can lead to inability of the liver to perform its biochemical function thus severely affecting the ..
  64. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) remains a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV is a member of the hepadnavirus group, double-stranded DNA viruses...
  65. BASIS FOR RENAL RESISTANCE TO ATRIAL NATRIURETIC PEPTIDE
    Michael Humphreys; Fiscal Year: 2004
    ..evidence that another mechanism contributes to renal ANP resistance in experimental nephrotic syndrome and liver cirrhosis. This mechanism involves a heightened activity of a specific phosphodiesterase (PDE) enzyme in renal target ..
  66. Alcohol Consumption & Mortality in the US 1950-2000
    William Kerr; Fiscal Year: 2009
    ..Outcome measures include age-standardized and specific mortality rates for liver cirrhosis, pancreatitis, other alcohol related cancers, heart disease (IHD), all explicitly alcohol-related causes and ..
  67. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..To have a control group with comparable prevalence of HCV infection, 80 patients with liver cirrhosis, who have no evidence of HCC (second control group), will be recruited from Baylor College of Medicine...
  68. VIRUS/HOST INTERACTIONS MODULATED BY HEPATITIC C VIRUS
    Radhakrishnan Padmanabhan; Fiscal Year: 2001
    ..S. as a result of complications of liver cirrhosis and long term virus persistence...