liver cirrhosis

Summary

Summary: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Top Publications

  1. pmc Liver fibrosis
    Ramon Bataller
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    J Clin Invest 115:209-18. 2005
  2. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
  3. pmc Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Physiol Rev 88:125-72. 2008
  4. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
  5. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
  6. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  7. pmc Macrophages: master regulators of inflammation and fibrosis
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Liver Dis 30:245-57. 2010
  8. ncbi The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    Joseph F Perz
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral Hepatitis, Epidemiology Branch, Atlanta, GA 30333, USA
    J Hepatol 45:529-38. 2006
  9. doi Non-invasive evaluation of liver fibrosis using transient elastography
    Laurent Castera
    Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
    J Hepatol 48:835-47. 2008
  10. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005

Detail Information

Publications333 found, 100 shown here

  1. pmc Liver fibrosis
    Ramon Bataller
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    J Clin Invest 115:209-18. 2005
    ..This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies...
  2. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
    ..Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease...
  3. pmc Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Physiol Rev 88:125-72. 2008
    ..As interest in this cell type intensifies, more surprises and mysteries are sure to unfold that will ultimately benefit our understanding of liver physiology and the diagnosis and treatment of liver disease...
  4. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
    ..A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease...
  5. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients...
  6. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  7. pmc Macrophages: master regulators of inflammation and fibrosis
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Liver Dis 30:245-57. 2010
    ..Although collagen-secreting myofibroblasts once were thought of as the master "producers" of fibrosis, this review will illustrate how macrophages function as the master "regulators" of fibrosis...
  8. ncbi The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    Joseph F Perz
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral Hepatitis, Epidemiology Branch, Atlanta, GA 30333, USA
    J Hepatol 45:529-38. 2006
    ..Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are well-recognized risk factors for cirrhosis and liver cancer, but estimates of their contributions to worldwide disease burden have been lacking...
  9. doi Non-invasive evaluation of liver fibrosis using transient elastography
    Laurent Castera
    Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
    J Hepatol 48:835-47. 2008
    ..Guidelines are needed for the use of TE in clinical practice...
  10. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  11. ncbi Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    ..Sampling variability becomes a major limitation when using more accurate methods such as automated image analysis...
  12. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  13. ncbi Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    A M Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, D 52074 Aachen, Germany
    J Cell Mol Med 10:76-99. 2006
    ....
  14. ncbi The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    A M Elsharkawy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Level D, South Academic Block, Southampton, SO16 6YD, UK
    Apoptosis 10:927-39. 2005
    ..The potential for known pharmacological agents such as gliotoxin, sulfasalazine, benzodiazepine ligands, curcumin and tanshinone I to induce HSC apoptosis and therefore to be used therapeutically will be explored...
  15. doi Evolving challenges in hepatic fibrosis
    Scott L Friedman
    Mount Sinai School of Medicine, Division of Liver Diseases, New York, NY 10029, USA
    Nat Rev Gastroenterol Hepatol 7:425-36. 2010
    ..As a result, focus is shifting towards overcoming key translational challenges in order to accelerate the development of new therapies for patients with chronic liver disease...
  16. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    ..Conclusion: Health care providers should not only focus on liver disease but also concentrate on aggressively modifying and treating their cardiovascular risk factors...
  17. ncbi Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
    Laurent Sandrin
    Echosens, Paris, France
    Ultrasound Med Biol 29:1705-13. 2003
    ..88 and 0.99 for the diagnosis of patients with significant fibrosis (>/= F2) and with cirrhosis ( = F4), respectively. The Fibroscan is a noninvasive, painless, rapid and objective method to quantify liver fibrosis...
  18. ncbi Liver fibrosis -- from bench to bedside
    Scott L Friedman
    Division of Liver Diseases, PO Box 1123, Mount Sinai School of Medicine, 1425 Madison Ave Room 1170F, New York, NY 10029, USA
    J Hepatol 38:S38-53. 2003
  19. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
    ....
  20. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  21. pmc Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    John P Iredale
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:539-48. 2007
    ..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ...
  22. ncbi Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  23. pmc Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
    L Xu
    Division of Liver Diseases, Department of Medicine, Box 1123, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11 70C, New York, NY10029, USA
    Gut 54:142-51. 2005
    ..We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells...
  24. pmc Mechanisms of hepatic fibrogenesis
    Ursula E Lee
    Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Ave, Room 11 76, New York, NY 10029, USA
    Best Pract Res Clin Gastroenterol 25:195-206. 2011
    ..Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease...
  25. ncbi Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
    Qing Liu
    Artificial Liver Treatment and Training Center, Beijing Youan Hospital and Capital University of Medical Sciences, Beijing, China
    Hepatology 39:1441-9. 2004
    ..In conclusion, treatment with synbiotics or fermentable fiber is an alternative to lactulose for the management of MHE in patients with cirrhosis...
  26. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    ..Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities (eg, obesity, diabetes) in the HCC risk in cirrhosis...
  27. ncbi Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies
    Gennaro D'Amico
    Gastroenterology Unit, Ospedale Cervello and University of Palermo, Italy
    J Hepatol 44:217-31. 2006
  28. doi Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
    Mireen Friedrich-Rust
    Department of Internal Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 134:960-74. 2008
    ..A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy...
  29. ncbi FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest
    Anais Vallet-Pichard
    Universite Paris Descartes, Paris, France
    Hepatology 46:32-6. 2007
    ..45 or >3.25 (kappa = 0.561, P < 0.01). A FIB-4 value <1.45 or >3.25 (64.6% of the cases) was concordant with FibroTest results in 92.1% and 76%, respectively...
  30. doi Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
    Karlin Raja Karlmark
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    Hepatology 50:261-74. 2009
    ..Thus, they may represent an interesting novel target for antifibrotic strategies...
  31. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology...
  32. pmc The prognosis of liver cirrhosis in recent years in Korea
    Young Sun Kim
    Institution of Digestive Disease and Nutrition, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 18:833-41. 2003
    ..These data suggest that the mortality of major complications of liver cirrhosis has considerably decreased during the last two decades, while there was no remarkable improvement in long-..
  33. doi Chemokines in liver inflammation and fibrosis
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
    Semin Liver Dis 30:215-25. 2010
    ..Here, we summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression...
  34. pmc Liver cirrhosis
    Detlef Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 371:838-51. 2008
    ..This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments...
  35. ncbi Roles of TGF-beta in hepatic fibrosis
    Axel M Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    Front Biosci 7:d793-807. 2002
    ....
  36. ncbi Serum markers detect the presence of liver fibrosis: a cohort study
    William M C Rosenberg
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
    Gastroenterology 127:1704-13. 2004
    ..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...
  37. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002
    ..In conclusion, a combination of easily accessible variables accurately predicts the absence of significant fibrosis and might render liver biopsy unnecessary in more than one third of patients with chronic hepatitis C...
  38. doi Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial
    Pedram Kharaziha
    Urology and Nephrology Research Center UNRC, Karolinska Institutet, Stockholm, Sweden, Karolinska University Hospital Solna, Sweden
    Eur J Gastroenterol Hepatol 21:1199-205. 2009
    ..End-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment...
  39. ncbi Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Gastroenterology 121:91-100. 2001
    ..Predicting advanced or progressive disease may help in selecting patients for liver biopsy and assist the development of therapeutic options...
  40. doi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    ..07; 95% CI, 1.02-1.14), and diabetes (OR, 1.8; 95% CI, 1.4-2.3) in the overall series, serum ferritin and diabetes in those with increased ALT, and only HOMA-IR (OR, 1.97; 95% CI, 1.2-3.7) in patients with normal ALT...
  41. ncbi Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    Suguru Oyagi
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871 Japan
    J Hepatol 44:742-8. 2006
    ..Here, we transplanted bone marrow-derived mesenchymal cells (BMMCs) to test their effect in liver-injured rats...
  42. ncbi Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    Yong Han Paik
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Hepatology 37:1043-55. 2003
    ..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury...
  43. doi Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus
    Juan Macias
    Infectious Diseases Unit, Hospital Universitario de Valme, Seville, Spain
    Hepatology 50:1056-63. 2009
    ..61 [0.39-0.93], P = 0.03), moderate-to-severe lobular necroinflammation (1.77 [1.16-2.7], P = 0.009), time between biopsies (1.11 [1.08-1.2], P = 0.01), and end of treatment response to anti-HCV therapy (0.41 [0.19-0.88], P = 0.02)...
  44. ncbi Lamivudine for patients with chronic hepatitis B and advanced liver disease
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    N Engl J Med 351:1521-31. 2004
    ..The effectiveness of antiviral therapy in preventing disease progression in patients with chronic hepatitis B and advanced fibrosis or cirrhosis is unknown...
  45. doi Treatment of chronic hepatitis C in Asia: when East meets West
    Ming Lung Yu
    Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Gastroenterol Hepatol 24:336-45. 2009
    ..Given the lack of an effective vaccine, optimal treatment of chronic HCV infection is now perceived as a 'must' in terms of public health strategies, as well as of the clinical setting for individual patients...
  46. doi Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..In addition, some of them arise through malignant transformation of a preexisting liver cell adenoma...
  47. ncbi Chemokines in liver inflammation and fibrosis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Italy
    Front Biosci 7:d1899-914. 2002
    ..These data indicate that chemokines in the liver may modulate the progression of liver fibrosis through actions on hepatic stellate cells...
  48. ncbi Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Gastroenterology 123:1084-9. 2002
    ..The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients...
  49. doi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
    ..Under the current liver-transplantation policy, donor organs are offered to patients with the highest risk of death...
  50. ncbi The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..By applying this model, a liver biopsy would have been avoided in 549 (75%) of the 733 patients, with correct prediction in 496 (90%)...
  51. doi Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus
    Bart J Veldt
    Erasmus MC University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
    Hepatology 47:1856-62. 2008
    ..013). Multivariate Cox regression analysis of patients with Ishak 6 cirrhosis showed that diabetes mellitus was independently associated with the development of HCC (hazard ratio, 3.28; 95% CI, 1.35-7.97; P = 0.009)...
  52. ncbi The epidemiology of nonalcoholic fatty liver disease in adults
    Jeanne M Clark
    Department of Medicine and Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Gastroenterol 40:S5-10. 2006
    ..More prospective studies are needed to determine the true risk factors for the development and progression of NAFLD to help identify patients at highest risk who might benefit from treatment trials...
  53. ncbi Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C
    Marianne Ziol
    UPRES EA 3406, University of Paris 13, Bobigny, France
    Hepatology 41:48-54. 2005
    ..In conclusion, noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C...
  54. doi Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation
    Alexander Dechene
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Hepatology 52:1008-16. 2010
    ..This was paralleled by collagen deposition, elevated alpha-SMA expression, and higher LS (25.6 +/- 3.0 kPa). ALF was associated with ductular progenitor proliferation...
  55. ncbi Projecting future complications of chronic hepatitis C in the United States
    Gary L Davis
    Division of Hepatology, Baylor Regional Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 9:331-8. 2003
    ..These data emphasize the need for greater access to transplantation by expansion of the donor pool, increasing use of split livers and living donors, and novel options such as xenotransplantation...
  56. ncbi Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
    ..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
  57. ncbi Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Insitute, and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, New South Wales, Australia
    Gastroenterology 125:1695-704. 2003
    ..Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection...
  58. ncbi Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Japan
    Ann Intern Med 131:174-81. 1999
    ..Previous studies on the effect of interferon therapy on the incidence of hepatocellular carcinoma have not sufficiently assessed degree of liver fibrosis, a major risk factor for hepatocellular carcinoma...
  59. pmc Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen, Germany
    J Clin Invest 120:4129-40. 2010
    ..Our results define a successful therapeutic approach to reduce experimental liver fibrosis by antagonizing Ccl5 receptors...
  60. ncbi Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    Gastroenterology 131:1743-51. 2006
    ..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks...
  61. ncbi Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
    Bart J Veldt
    Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 147:677-84. 2007
    ..Clinical outcomes of chronic hepatitis C infection in patients with advanced fibrosis include liver failure, hepatocellular carcinoma, and death...
  62. ncbi Acute viral hepatitis increases liver stiffness values measured by transient elastography
    Umberto Arena
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi Firenze, Italy
    Hepatology 47:380-4. 2008
    ..LSM does not represent a reliable instrument to detect the presence of advanced fibrosis and cirrhosis in patients presenting with a clinical picture of acute hepatitis...
  63. ncbi Hepatic Encephalopathy
    A T Blei
    Department of Medicine, Lakeside VA Medical Center and Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 96:1968-76. 2001
    ..In patients with significant deficits or complaints, a therapeutic program based on dietary manipulations and/or nonabsorbable disaccharides may be tried. Benzodiazepines should not be used for patients with sleep difficulties...
  64. doi Characterization of fecal microbial communities in patients with liver cirrhosis
    Yanfei Chen
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, PR China
    Hepatology 54:562-72. 2011
    b>Liver cirrhosis is the pathologic end stage of chronic liver disease. Increasing evidence suggests that gut flora is implicated in the pathogenesis of liver cirrhosis complications...
  65. doi The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    Mustafa S Ascha
    Department of Gastroenterology and Hepatology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 51:1972-8. 2010
    ..Compared with nondrinkers, patients who reported any regular alcohol consumption were at greater risk for HCC development (hazard ratio: 3.6; P25, P75: 1.5, 8.3)...
  66. doi A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen
    N Barascuk
    Nordic Bioscience A S, Herlev, Denmark
    Clin Biochem 43:899-904. 2010
    ..Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for quantification of MMP-9 derived collagen type III (CO3) degradation...
  67. ncbi Liver fibrosis: a dynamic and potentially reversible process
    Davide Povero
    Department of Experimental Medicine and Oncology, University of Torino, Italy
    Histol Histopathol 25:1075-91. 2010
    ..representing a major driving force for progressive accumulation of ECM components, eventually leading to liver cirrhosis. Cirrhosis is characterized by fibrous septa dividing the hepatic parenchyma into regenerative pseudo-lobules,..
  68. doi Pathogenesis of liver fibrosis
    Virginia Hernandez-Gea
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pathol 6:425-56. 2011
    ..As pathways of fibrogenesis are increasingly clarified, the key challenge will be translating new advances into the development of antifibrotic therapies for patients with chronic liver disease...
  69. doi Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B
    S U Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 32:498-505. 2010
    ..Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan...
  70. pmc Gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with CCl4-induced fibrosis
    Isabel Gómez-Hurtado
    Unidad Hepática, Hospital General Universitario, Alicante, Spain
    PLoS ONE 6:e23037. 2011
    ..Gut is the major source of endogenous bacteria causing infections in advanced cirrhosis. Intestinal barrier dysfunction has been described in cirrhosis and account for an increased bacterial translocation rate...
  71. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
    ..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
  72. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  73. doi Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection
    Marija Zeremski
    Division of Gastroenterology and Hepatology and Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, USA
    J Infect Dis 200:1774-80. 2009
    ..We evaluated the potential of peripheral chemokine levels to discriminate among patients with chronic HCV infection who had different stages of fibrosis...
  74. ncbi Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease
    S H Caldwell
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA
    Hepatology 29:664-9. 1999
    ..Although there is some diversity that indicates more than one cause, our findings suggest that NASH plays an under-recognized role in many patients with cryptogenic cirrhosis, most of whom are older, type 2 diabetic and obese females...
  75. ncbi Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    Hashem B El-Serag
    Section of Gastroenterology, Houston Departmentof Veterans Affais Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 126:460-8. 2004
    ..An association between diabetes and chronic liver disease has been reported. However, the temporal relationship between these conditions remains unknown...
  76. ncbi Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology. Consensus Interferon Study Group
    J G McHutchison
    Division of Gastroenterology Hepatology, Scripps Clinic, La Jolla, California 92037, USA
    J Gastroenterol Hepatol 15:945-51. 2000
    ..To determine whether serum HA was a reliable predictor of cirrhosis and fibrosis, we examined serum HA concentrations from 486 chronic Hepatitis C virus (HCV) patients...
  77. ncbi The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts
    A M Gressner
    Institut für Klinische Chemie und Pathobiochemie Zentrallaboratorium, RWTH Universitätsklinikum, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Cell Tissue Res 292:447-52. 1998
    ..Fibrosis following liver damage and factors influencing this process are discussed with special reference to hepatic stellate cells and their transformation to myo- fibroblasts...
  78. ncbi Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005
    ..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
  79. pmc Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
    Mirella Fraquelli
    Second Division of Gastroenterology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Gut 56:968-73. 2007
    ..This study investigated these aspects...
  80. doi Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
    J Hepatol 52:191-8. 2010
    ..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
  81. ncbi Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group
    Y Benhamou
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitié Salpêtrière and UPRES A 8067, Paris, France
    Hepatology 30:1054-8. 1999
    ..HIV seropositivity accelerates HCV-related liver fibrosis progression. In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate...
  82. doi Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis
    Jurgen Rehm
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada
    Drug Alcohol Rev 29:437-45. 2010
    Alcohol is an established risk factor for liver cirrhosis. It remains unclear, however, whether this relationship follows a continuous dose-response pattern or has a threshold. Also, the influences of sex and end-point (i.e. mortality vs...
  83. ncbi Improved survival after variceal bleeding in patients with cirrhosis over the past two decades
    Nicolas Carbonell
    Hopital Saint Antoine, Service d Hepatogastroenterologie, AP HP, Universite Pierre et Marie Curie, Paris, France
    Hepatology 40:652-9. 2004
    ....
  84. pmc Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis
    Y Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Gut 56:284-92. 2007
  85. ncbi Viral hepatitis C
    Thierry Poynard
    Service d Hepato gastro enterologie, Groupe Hospitalier Pitie Salpetriere, Universite, Paris, France
    Lancet 362:2095-100. 2003
    ..These antiviral treatments reduce liver fibrosis progression and can reverse cirrhosis. Unfortunately, even in developed countries, death due to hepatitis C is increasing because of inadequate detection and treatment...
  86. pmc Novel serum markers of fibrosis progression for the follow-up of hepatitis C virus-infected patients
    Frederique Caillot
    Inserm Unité 905, Faculte de Medecine Pharmacie, Rouen Cedex, France
    Am J Pathol 175:46-53. 2009
    ..Our description of three novel serum markers and their potential use as serological tests for the non-invasive diagnosis of liver fibrosis open new opportunities for better follow-up of hepatitis C virus-infected patients...
  87. ncbi Severe liver fibrosis or cirrhosis: accuracy of US for detection--analysis of 300 cases
    Agostino Colli
    Department of Internal Medicine, Ospedale A Manzoni, Lecco, Italy
    Radiology 227:89-94. 2003
    ..To determine the accuracy of various ultrasonographic (US) signs for assessment of the degree of liver fibrosis, with histologic results as reference standard...
  88. ncbi Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease
    Ayako Suzuki
    Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Liver Int 25:779-86. 2005
    ..To determine whether serum hyaluronic acid reliably predicts the severity of hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD)...
  89. ncbi FibroIndex, a practical index for predicting significant fibrosis in patients with chronic hepatitis C
    Masahiko Koda
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
    Hepatology 45:297-306. 2007
    ..Conclusion: The FibroIndex is a simple and reliable index for predicting significant fibrosis in chronic hepatitis C and could also be used as a surrogate marker during antifibrotic treatment for chronic hepatitis C...
  90. ncbi Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients
    Maria W Smith
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    Gastroenterology 130:179-87. 2006
    ..Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis...
  91. ncbi Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics
    Uwe J F Tietge
    Dept of Medicine, NWFZ, 5 Ebene, Charite Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Am J Physiol Endocrinol Metab 287:E82-9. 2004
    ....
  92. ncbi Modeling liver fibrosis in rodents
    Christothea Constandinou
    University of Southampton, Southampton General Hospital, Southampton, UK
    Methods Mol Med 117:237-50. 2005
    ..Mechanistic studies using gene knockout and transgenic animals can also be established using CCl(4). Together these models have provided unparalleled insights into the mechanisms underlying hepatic fibrosis...
  93. doi Diagnosis and quantitation of fibrosis
    Diarmuid S Manning
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:1670-81. 2008
    ..This article reviews the current role of liver biopsy in the assessment of hepatic fibrosis and discusses the role of the newer noninvasive methods including serum markers and radiologic tests...
  94. ncbi Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies
    Stefanie Hemmann
    Department of Medicine II, Gastroenterology, University Hospital Giessen and Marburg GmbH, Paul Meimberg Str 5, 35392 Giessen, Germany
    J Hepatol 46:955-75. 2007
    ..The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table...
  95. ncbi Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C
    Carolin Lackner
    Department of Pathology, Medical University Graz, Graz, Austria
    Hepatology 41:1376-82. 2005
    ..In conclusion, simple fibrosis tests may render liver biopsy unnecessary only in a minority of patients with chronic HCV. Improved serum fibrosis markers with greater sensitivity for severe fibrosis or cirrhosis are needed...
  96. ncbi The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Ann Intern Med 147:58-61. 2007
    ..5 times the upper limit of normal...
  97. ncbi Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection
    Ivan Bieche
    Laboratoire de Génétique Moléculaire UPRES EA 3618, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Virology 332:130-44. 2005
    ..Some of the genes identified here could form the basis for new approaches aimed at refining IFN-based therapies for chronic HCV infection...
  98. ncbi Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators
    Gennaro D'Amico
    Department of Medicine, Ospedale V Cervello, Palermo, Italy
    Hepatology 38:599-612. 2003
    ..Initial treatment stops bleeding in 90% of patients. Accurate predictive rules are provided for early recognition of high-risk patients...
  99. ncbi A novel panel of blood markers to assess the degree of liver fibrosis
    Paul Cales
    Laboratoire HIFIH, UPRES 3859, IFR 132, Universite, Angers, France
    Hepatology 42:1373-81. 2005
    ..Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis, blood tests for the area of liver fibrosis provide a quantitative estimation of the amount of fibrosis, which is especially useful in cirrhosis...
  100. doi Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 51:1209-17. 2010
    ..Conclusion: In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis...
  101. pmc Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
    J Foucher
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Gut 55:403-8. 2006
    ..5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease...

Research Grants82

  1. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 1993
    ..Far East Asia and tropical Africa represents 10% or more of the population and chronic active hepatitis and liver cirrhosis are major causes of mortality. HBV infection can generally be prevented by vaccination...
  2. Arterial Remodeling in Chronic Liver Diseases
    Yasuko Iwakiri; Fiscal Year: 2010
    In liver cirrhosis, chronic portal hypertension causes hemodynamic abnormalities and leads to thinning of the arterial wall in the splanchnic and systemic circulation...
  3. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2010
    ..Thus, the preliminary studies identify TAL deficiency as a novel cause of liver cirrhosis and HCC which are preventable by lifelong supplementation of the potent antioxidant NAC...
  4. Inhibition of HCV as an Opportunistic HIV Co-infection
    James C Fishbein; Fiscal Year: 2010
    ..This results in dramatic exacerbation of HCV and its accelerated progress to liver cirrhosis and death...
  5. Inhibition of HCV as an Opportunistic HIV Co-infection
    RAMACHANDRA HOSMANE; Fiscal Year: 2009
    ..This results in dramatic exacerbation of HCV and its accelerated progress to liver cirrhosis and death...
  6. Hepatitis C Virus and Hepatocellular Carcinoma
    Srikanta Dash; Fiscal Year: 2006
    ..Treatment for liver cancer and liver cirrhosis is transplantation...
  7. Mechanisms of RNA binding and remodeling proteins
    KEVIN RANEY; Fiscal Year: 2009
    ..virus infection that can lead to liver fibrosis and, progressively, to severe and fatal diseases, including liver cirrhosis and liver cancer...
  8. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2009
    The hepatitis B virus (HBV) remains a global cause of chronic liver diseases, including liver cirrhosis and cancer. Current antiviral therapy for chronic hepatitis B is only partially effective...
  9. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2010
    The hepatitis B virus (HBV) remains a global cause of chronic liver diseases, including liver cirrhosis and cancer. Current antiviral therapy for chronic hepatitis B is only partially effective...
  10. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2010
    ..Millions of people each year die from liver cirrhosis. Liver cancer is among the top five most prevalent tumor types worldwide, with an estimated 1 million deaths ..
  11. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    John Y L Chiang; Fiscal Year: 2010
    ..Dysregulation of bile acid metabolism causes cholestatic liver injury and contributes to liver cirrhosis, steatosis, dyslipidemia, diabetes, obesity, and atherosclerosis...
  12. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    Project Summary/Abstract: Liver cirrhosis is a chronic and degenerative disease that can lead to inability of the liver to perform its biochemical function thus severely affecting the quality of patients' life...
  13. Mechanistic X-Ray Crystallography of Mononuclear Iron Enzymes, TauD and HppE
    Danny Yun; Fiscal Year: 2007
    ..will contribute to the advancement of clinical research on several disease states, such as cancer, alcoholic liver cirrhosis, Ehlers-Danlos syndrome, and fibrotic disease, which are associated with dysfunction in a number of enzymes ..
  14. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    Hepatitis B virus (HBV) remains a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV is a member of the hepadnavirus group, double-stranded DNA viruses...
  15. BASIS FOR RENAL RESISTANCE TO ATRIAL NATRIURETIC PEPTIDE
    Michael Humphreys; Fiscal Year: 2004
    ..evidence that another mechanism contributes to renal ANP resistance in experimental nephrotic syndrome and liver cirrhosis. This mechanism involves a heightened activity of a specific phosphodiesterase (PDE) enzyme in renal target ..
  16. Ribavirin Pharmacokinetics, Race and HCV Treatment
    Charles Howell; Fiscal Year: 2007
    Chronic hepatitis C virus (HCV) is the most common cause for liver cirrhosis and a major risk factor for primary hepatocellular carcinoma (HCC) in the United States...
  17. Alcohol Consumption & Mortality in the US 1950-2000
    William Kerr; Fiscal Year: 2009
    ..Outcome measures include age-standardized and specific mortality rates for liver cirrhosis, pancreatitis, other alcohol related cancers, heart disease (IHD), all explicitly alcohol-related causes and ..
  18. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2001
    ..in bile acid metabolism causes malabsorption of nutrients, proliferation of hepatocytes, cholestasis, liver cirrhosis and colon cancer in humans...
  19. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2010
    ..In many cases HCV infection becomes chronic, which can progress to liver cirrhosis and hepatocellular carcinoma...
  20. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2010
    ..Most infections become chronic often leading to liver cirrhosis and cancer. In the United States 10,000 to 20,000 deaths a year are caused by chronic HCV infection...
  21. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2007
    ..liver diseases will supervise the epidemiological and clinical components of hepatitis C virus (HCV) and liver cirrhosis. I propose two developmental projects that will further my career progress...
  22. INTERLEUKIN 6 ROLE IN ALCOHOLIC LIVER CIRRHOSIS
    Marcos Rojkind; Fiscal Year: 1999
    b>Liver cirrhosis is among the leading causes of death worldwide. Approximately 50% of the deaths attributable to liver cirrhosis recognize alcohol as the main ethiologic agent. Currently, there is no accepted treatment for this disease...
  23. Viral Vaccine Vectors to Prevent Hepatocellular Carcinoma
    Michael Robek; Fiscal Year: 2009
    ..Relevance: Chronic hepatitis B virus (HBV) infection leads to millions of deaths each year worldwide from liver cirrhosis and hepatocellular carcinoma...
  24. Viral Vaccine Vectors to Prevent Hepatocellular Carcinoma
    Michael Robek; Fiscal Year: 2009
    ..Relevance: Chronic hepatitis B virus (HBV) infection leads to millions of deaths each year worldwide from liver cirrhosis and hepatocellular carcinoma...
  25. Dissecting the Aggregation of AMA in Families of PBC Patients
    Konstantinos Lazaridis; Fiscal Year: 2007
    ..PBC) is an idiopathic, chronic cholestatic liver disease that affects mainly women and predisposes to liver cirrhosis. Despite medical therapy PBC is often progressive, resulting in diminished quality of life and shortening ..
  26. Synergistic actions by multiple Toll-like receptors in alcoholic liver disease
    Ekihiro Seki; Fiscal Year: 2010
    ..only LPS, but also bacterial DNA levels in blood and ascites are elevated in patients with alcoholic-induced liver cirrhosis. Bacterial DNA is recognized by TLR9 that is widely expressed in immune cells including Kupffer cells, ..
  27. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..To have a control group with comparable prevalence of HCV infection, 80 patients with liver cirrhosis, who have no evidence of HCC (second control group), will be recruited from Baylor College of Medicine...
  28. ENDOTHELIN AND LIVER CIRRHOSIS
    Chandrashekhar Gandhi; Fiscal Year: 2002
    ..surgical therapies for portal hypertension a notoriously frustrating, often fatal, clinical complication of liver cirrhosis, have limited success due to the lack of clear understanding of its pathophysiology...
  29. Arterial Remodeling in Chronic Liver Diseases
    Yasuko Iwakiri; Fiscal Year: 2009
    In liver cirrhosis, chronic portal hypertension causes hemodynamic abnormalities and leads to thinning of the arterial wall in the splanchnic and systemic circulation...
  30. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 2002
    ..The consequences of chronic HBV infection can include debilitating chronic active hepatitis, liver cirrhosis, and primary hepatocellular carcinoma which are major causes of mortality...
  31. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2011
    ..modulator of liver tumor cell growth, AhR ligand, and is elevated in carriers of BVR mutation with end-stage liver cirrhosis. Indeed, a compromised BVR activity causes "green jaundice", which is nearly always fatal...
  32. Insulin resistance in the pathogenesis of NASH
    SONIA NAJJAR; Fiscal Year: 2009
    ..Because NASH frequently progresses to liver cirrhosis, and is becoming the leading cause of liver transplant in the US, it is imperative to understand its ..