alcoholic fatty liver

Summary

Summary: Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.

Top Publications

  1. ncbi Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat
    Keunsook Cho
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Republic of Korea
    J Med Food 12:1293-301. 2009
  2. pmc Molecular mechanisms of alcoholic fatty liver
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 33:191-205. 2009
  3. ncbi Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
    Kwan Hoon Moon
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Hepatology 44:1218-30. 2006
  4. ncbi Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
  5. ncbi Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 34:39-43. 2004
  6. ncbi A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    Michal Carmiel-Haggai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:136-8. 2005
  7. ncbi Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha
    David W Crabb
    Department of Medicine, Indiana University, Emerson Hall, Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 34:35-8. 2004
  8. ncbi Adiponectin: a key adipokine in alcoholic fatty liver
    Min You
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Box 8, University of South Florida, Tampa, FL 33612, USA
    Exp Biol Med (Maywood) 234:850-9. 2009
  9. ncbi Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease
    James Frith
    UK NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Hepatol 52:112-6. 2010
  10. ncbi Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat
    S Yamada
    Department of Clinical Pathophysiology, University of Occupational Environmental Health, Fukuoka, Japan
    Hepatology 32:278-88. 2000

Detail Information

Publications247 found, 100 shown here

  1. ncbi Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat
    Keunsook Cho
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Republic of Korea
    J Med Food 12:1293-301. 2009
    ..dietary supplementation with Codonopsis lanceolata root water extract attenuates the development of alcoholic fatty liver in rats and to elucidate the molecular mechanism for such an effect...
  2. pmc Molecular mechanisms of alcoholic fatty liver
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 33:191-205. 2009
    b>Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis if alcohol consumption is continued...
  3. ncbi Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
    Kwan Hoon Moon
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Hepatology 44:1218-30. 2006
    ..In conclusion, our results help to explain the underlying mechanism for mitochondrial dysfunction and increased susceptibility to alcohol-mediated liver damage...
  4. ncbi Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  5. ncbi Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 34:39-43. 2004
    b>Alcoholic fatty liver is the earliest and most common response of the liver to alcohol in heavy alcohol use, and it may be a precursor of more severe forms of liver injury...
  6. ncbi A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    Michal Carmiel-Haggai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:136-8. 2005
    ..A role for oxidative stress is suggested via increased NADPH oxidase activity, lipid peroxidation, protein carbonyl formation, and low antioxidant defense...
  7. ncbi Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha
    David W Crabb
    Department of Medicine, Indiana University, Emerson Hall, Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 34:35-8. 2004
    ..Blockade of PPARalpha function during ethanol consumption contributes to the development of alcoholic fatty liver, which can be overcome by WY14,643.
  8. ncbi Adiponectin: a key adipokine in alcoholic fatty liver
    Min You
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Box 8, University of South Florida, Tampa, FL 33612, USA
    Exp Biol Med (Maywood) 234:850-9. 2009
    b>Alcoholic fatty liver is a major risk factor for advanced liver injuries such as steatohepatitis, fibrosis, and cirrhosis...
  9. ncbi Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease
    James Frith
    UK NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Hepatol 52:112-6. 2010
    ..To increase exercise in NAFLD it is important to understand the barriers to performing it...
  10. ncbi Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat
    S Yamada
    Department of Clinical Pathophysiology, University of Occupational Environmental Health, Fukuoka, Japan
    Hepatology 32:278-88. 2000
    ..b>Alcoholic fatty liver exposed to I/R showed a rapid increase in nuclear factor-kappaB (NF-kappaB) binding activity at 1 hour ..
  11. ncbi Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine
    Fan Sun
    Department of Pharmacology, Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China
    Phytomedicine 17:669-73. 2010
    ..A mouse model with alcoholic fatty liver was induced by orally feeding 52% erguotou wine by gavage when they were simultaneously treated with ..
  12. ncbi [Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis]
    J Wiegand
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Deutschland
    Internist (Berl) 48:154-63. 2007
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome...
  13. pmc Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids
    Byoung Joon Song
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rm 2S 30, Bethesda, MD 20892 9410, USA
    J Hepatol 49:262-73. 2008
    ..This study was aimed at studying the mechanisms by which a DHA/AA-supplemented diet prevents alcohol-induced fatty liver...
  14. ncbi Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
    Charles S Lieber
    Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Alcohol 34:9-19. 2004
    ..Progress in the understanding of the pathogenesis of alcoholic fatty liver and its progression to inflammation and fibrosis has resulted in prospects for their better prevention and ..
  15. ncbi Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats
    Ki M Mak
    Mount Sinai School of Medicine, New York, New York, USA
    Alcohol Clin Exp Res 32:683-9. 2008
    ..evaluated whether alcohol feeding enhances ADRP expression and whether ADRP is a lipid droplet marker in alcoholic fatty liver of rats...
  16. ncbi Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps
    Sang Tae Hwang
    Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea
    J Gastroenterol Hepatol 25:562-7. 2010
    Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver...
  17. ncbi Crohn's disease-induced non-alcoholic fatty liver disease (NAFLD) sensitizes for severe acute hepatitis B infection and liver failure
    A Canbay
    Division of Gastroenterology and Hepatology, University Hospital Essen
    Z Gastroenterol 44:245-8. 2006
    Non-alcoholic fatty liver disease (NAFLD) commonly is associated with chronic inflammatory bowel disease (CIBD) and usually is considered to be stable and benign...
  18. pmc Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
    Zheng Shen
    Department of Molecular Pharmacology, University of South Florida Health Sciences Center, Tampa, Florida 33612, USA
    Am J Physiol Gastrointest Liver Physiol 298:G364-74. 2010
    The development of alcoholic fatty liver is associated with reduced adipocyte-derived adiponectin levels, decreased hepatic adiponectin receptors, and deranged hepatic adiponectin signaling in animals...
  19. ncbi Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    Thierry Gustot
    Division of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Brussels, Belgium
    Hepatology 43:989-1000. 2006
    ..This study addressed the contribution of other TLRs and ligands to alcoholic fatty liver. C57Bl6/J mice were fed a modified Lieber-DeCarli diet...
  20. ncbi Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met
    Kengo Tomita
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Gastroenterology 126:873-85. 2004
    ..This study aimed to examine if pioglitazone, an antidiabetic reagent serving as a ligand of peroxisome proliferator-activated receptor gamma (PPAR gamma), could prevent alcoholic fatty liver.
  21. ncbi Adiponectin and alcoholic fatty liver: Is it, after all, about what you eat?
    Frank A Anania
    Hepatology 42:530-2. 2005
  22. pmc Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 42:568-77. 2005
    ..In conclusion, the protective action of saturated fat against the development of alcoholic fatty liver in mice is partially mediated through induction of adiponectin...
  23. ncbi Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    Min You
    Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL 33612, USA
    J Nutr 138:497-501. 2008
    ..mechanism underlying the protective effect of a high saturated fat (HSF) diet against the development of alcoholic fatty liver in mice...
  24. pmc Resveratrol alleviates alcoholic fatty liver in mice
    Joanne M Ajmo
    Dept of Molecular Pharmacology, School of Basic Biomedical Sciences, College of Medicine, Box 8, Univ of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Am J Physiol Gastrointest Liver Physiol 295:G833-42. 2008
    b>Alcoholic fatty liver is associated with inhibition of sirtuin 1 (SIRT1) and AMP-activated kinase (AMPK), two critical signaling molecules regulating the pathways of hepatic lipid metabolism in animals...
  25. pmc AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease
    Gary Beale
    Paul O Gorman Building, Northern Institute for Cancer Research, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    BMC Cancer 8:200. 2008
    The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies...
  26. ncbi Adiponectin and alcoholic fatty liver disease
    Christopher Q Rogers
    Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL 33612, USA
    IUBMB Life 60:790-7. 2008
    Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis...
  27. ncbi Weight loss: cornerstone in the treatment of non-alcoholic fatty liver disease
    H Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Austria
    Minerva Gastroenterol Dietol 56:159-67. 2010
    ..Therefore, new weight-loss inducing agents are eagerly awaited to increase the percentage of obese people to benefit from weight reduction...
  28. ncbi Plasma lipid parameters in patients with alcoholic fatty liver after treatment with essential phospholipids
    L Turecky
    Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Bratisl Lek Listy 104:227-31. 2003
    ..The purpose of our study was to investigate the effect of the administration of essential phospholipids on plasma lipid parameters in patients with alcoholic fatty liver.
  29. ncbi Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver
    O Y Lukivskaya
    Institute of Biochemistry, National Academy of Sciences, 230017 Grodno, Belarus
    Alcohol 25:99-105. 2001
    ..and fatty acid metabolism and the possible relation of these substances to the development of alcoholic fatty liver in rats...
  30. ncbi Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver
    J Caballeria
    Liver Unit, Hospital Clinic i Provincial, University of Barcelona, Spain
    J Hepatol 28:54-60. 1998
    Our aim was to investigate the effectiveness of metadoxine (pyridoxol L, 2 pyrrolidone-5-carboxylate) in the treatment of alcoholic fatty liver.
  31. ncbi Traditional Chinese Medicine improves dysfunction of peroxisome proliferator-activated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats
    Hyun Jeong Kwon
    Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130 701, Korea
    Biofactors 23:163-76. 2005
    ..Impairment of PPARalpha and MTP function during ethanol consumption contributes to the development of alcohol-induced fatty liver, which can be overcome by TCM...
  32. ncbi Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Alcohol Clin Exp Res 29:1018-26. 2005
    ....
  33. ncbi Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis
    S Kaser
    Clinical Division of General Internal Medicine, Department of Medicine, Medical University Innsbruck, Austria
    J Intern Med 258:274-80. 2005
    ..The adipocytokine adiponectin has been proposed to play important roles in the regulation of energy homeostasis, insulin sensitivity and shows anti-inflammatory properties...
  34. ncbi [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]
    László Váli
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 146:2409-14. 2005
    ..The effectiveness of the drug is established both in acute and in chronic alcoholism, moreover it helps in staying abstinent...
  35. ncbi Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis
    Rita M Ramalho
    Centro de Patogenese Molecular, Faculty of Pharmacy, University of Lisbon and Department of Gastroenterology, Hospital of Santa Maria, Lisbon, Portugal
    Eur J Gastroenterol Hepatol 18:21-9. 2006
    ..Apoptosis may play a role in the pathogenesis of alcoholic (ASH) and non-alcoholic steatohepatitis (NASH). In this study, we investigated the modulation of apoptosis-related liver proteins in steatohepatitis...
  36. ncbi Differentiation of nonalcoholic from alcoholic steatohepatitis: are routine laboratory markers useful?
    Lili Kazemi-Shirazi
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 120:25-30. 2008
    ..Specific markers for differentiation of nonalcoholic (NASH) from alcoholic steatohepatitis (ASH) are lacking. We investigated the role of routine laboratory parameters in distinguishing NASH from ASH...
  37. ncbi Cirrhosis after orthotopic liver transplantation in the absence of primary disease recurrence
    Moataz Seyam
    Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Liver Transpl 13:966-74. 2007
    ..Chronic hepatitis is the most frequent underlying pathological process in cases where the cause of cirrhosis remains uncertain...
  38. ncbi [Steatosis, chronic hepatitis virus C infection and homocysteine]
    Xavier Roblin
    Département d Hépato Gastroentérologie, CHU Michallon, Grenoble, France
    Gastroenterol Clin Biol 31:415-20. 2007
    ..These data should be confirmed to evaluate the importance of homocysteine dosage in the diagnosis of NASH. Finally, treatment of hyperhomocysteinemia could have favourable consequences in steatopathies and HCV infection...
  39. ncbi Antioxidant mechanism of hepatoprotection by ursodeoxycholic acid in experimental alcoholic steatohepatitis
    O Lukivskaya
    Department of Experimental Hepatology, Institute of Biochemistry, National Academy of Sciences, Grodno, Belarus
    Adv Med Sci 51:54-9. 2006
    ..The aim of this study was to evaluate the role of an antioxidant factor in the hepatoprotective effect of ursodeoxycholic acid (UDCA) in rat alcoholic steatohepatitis...
  40. ncbi Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion
    Kang Hun Cho
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Arch Pharm Res 30:50-7. 2007
    ..In conclusion, chronic ethanol consumption was found to potentiate hepatocellular damage as indicated by abnormalities in microsomal drug metabolizing function during I/R...
  41. ncbi Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis
    Igor Bykov
    National Public Health Institute, Departments of Mental Health and Alcohol Research, Finland
    J Hepatol 46:907-14. 2007
    ..To understand the underlying molecular mechanisms we analyzed lipid parameters and liver gene expression profiles in these mice...
  42. ncbi The role of cytokines and chemokines in the development of steatohepatitis
    Patricia F Lalor
    Liver Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    Semin Liver Dis 27:173-93. 2007
    ..A better understanding of this process might allow therapeutic intervention to switch off the inflammatory response before irreversible damage occurs in both ALD and NAFLD...
  43. ncbi S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1231-9. 2007
    ....
  44. ncbi Pathology of nonalcoholic fatty liver disease
    Matthew M Yeh
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 6100, USA
    Am J Clin Pathol 128:837-47. 2007
    ..Finally, other aspects for consideration by practicing pathologists, such as sampling issues, histopathologic findings after therapeutic interventions, and recurrence after liver transplantation, are addressed...
  45. ncbi Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Hepatol 45:717-24. 2006
    ..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
  46. ncbi Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
    Javier García-Villafranca
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Ciudad Universitaria, S N, Madrid, Spain
    Biochimie 90:460-6. 2008
    ..Taken together, these findings suggest that a decreased AMPK activity may have an important role in the development of alcoholic fatty liver.
  47. ncbi Complement C3 contributes to ethanol-induced liver steatosis in mice
    Igor Bykov
    National Public Health Institute, Department of Mental Health and Alcohol Research, and Department of Bacteriology and Immunology, Helsinki University Central Hospital, Finland
    Ann Med 38:280-6. 2006
    ..This prompted us to study the development of alcoholic liver steatosis in mice lacking C3 (C3-/-)...
  48. ncbi Interleukin-8 in the blood serum of patients with alcoholic liver disease
    Renata Swiatkowska-Stodulska
    Department of Internal Medicine, Endocrinology and Hemostatic Disorders, Institute of Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Med Sci Monit 12:CR215-20. 2006
    ..The aim of the present study was to evaluate serum IL-8 concentration in patients with chronic alcoholic liver disease...
  49. ncbi Nonalcoholic steatohepatitis--a histological perspective
    Puja Sakhuja
    Indian J Pathol Microbiol 49:163-72. 2006
    ..In this review we clarify the terminology and describe the histological features associated with NASH. Criteria for diagnosis, grading and staging systems and role of liver biopsy is also discussed...
  50. pmc The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Biochem Pharmacol 75:981-95. 2008
    ..The combination diet is an efficient model of steatohepatitis...
  51. ncbi Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
    Kiyoshi Nagata
    Department of Environmental Health Science, Tohoku Pharmaceutical University, Sendai, Japan
    J Toxicol Sci 32:453-68. 2007
    ..Some of the most definitive data on the importance of the innate immune system or oxidative stress in the pathogenesis of liver disease come from studies of alcoholic and non-alcoholic steatohepatitis in animals...
  52. ncbi Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
    Min You
    Dept of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Box 8, Univ of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Am J Physiol Gastrointest Liver Physiol 294:G892-8. 2008
    ..in mediating the effects of ethanol on SREBP-1 and hepatic lipid metabolism, as well as the development of alcoholic fatty liver. Hence, SIRT1 may represent a novel therapeutic target for treatment of human alcoholic fatty liver disease...
  53. pmc Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
    Michele T Pritchard
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44905, USA
    Gastroenterology 132:1117-26. 2007
    ..The complement pathway is an important component of the innate and adaptive immune response. Here we tested the hypothesis that activation of complement is required for development of ethanol-induced fatty liver...
  54. ncbi The effect of taurine depletion by beta-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats
    M D Kerai
    Pharmacy Department, Kings' College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UK
    Alcohol Alcohol 36:29-38. 2001
    ..These in vivo findings demonstrate for the first time that animals treated with beta-alanine may be more susceptible to ethanol-induced hepatic dysfunction, possibly as a result of taurine depletion...
  55. ncbi Cognitive lifetime drinking history in nonalcoholic fatty liver disease: some cases may be alcohol related
    Paul H Hayashi
    Wilford Hall Medical Center, Gastroenterology and Pathology Departments, Brooke Army Medical Center, San Antonio, Texas, USA
    Am J Gastroenterol 99:76-81. 2004
    ..We aimed to determine the prevalence of significant alcohol intake in previously diagnosed nonalcoholic fatty liver (NAFL) patients...
  56. ncbi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis...
  57. ncbi Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index
    Päivikki I Alatalo
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinajoki, Finland
    Am J Clin Nutr 88:1097-103. 2008
    ..The magnitude of alterations occurring among moderate drinkers has remained obscure...
  58. ncbi Role of the life span determinant P66(shcA) in ethanol-induced liver damage
    Osvaldo R Koch
    Department of Pathology, Faculty of Medicine University of Buenos Aires, Buenos Aires, Argentina
    Lab Invest 88:750-60. 2008
    ..Taken together, the above observations clearly indicate a role for p66 in alcohol-induced cell damage, likely via a cell-autonomous mechanism involving reduced expression of antioxidant defenses and mitochondrial dysfunction...
  59. ncbi [Alcoholic liver disease]
    Marek Waluga
    Katedry i Kliniki Gastroenterologii Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 56:61-70. 2003
    ..Apart from abstinence, the treatment of alcohol liver disease is based on hyperalimentation, since alcoholism is generally associated with protein malnutrition. In severe forms of alcohol hepatitis corticosteroids are recommended...
  60. ncbi In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 125:202-15. 2003
    ..This is further complicated by the prevalence of steatosis in about 13%-50% of donor livers, which is associated with a high risk of dysfunction and primary nonfunction...
  61. pmc The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    Aimin Xu
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Clin Invest 112:91-100. 2003
    ..These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases...
  62. ncbi Alcoholic and nonalcoholic steatohepatitis
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, 4th Floor, SLUH, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 6:399-420, vii. 2002
    ..In many instances, however, the microscopic lesions of these two processes are similar, likely as a reflection of common pathogenetic pathways, and the distinction between the two is ultimately clinically derived...
  63. ncbi Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Research Center for Liver Disease and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 124:1488-99. 2003
    ..This novel ER stress mechanism of alcoholic liver injury was studied in the model of intragastric alcohol-fed mice...
  64. ncbi [Therapy effects of fenofibrate on alcoholic fatty liver and drug-induced fatty liver in rats]
    Ming Yan
    Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Gan Zang Bing Za Zhi 11:86-9. 2003
    To investigate the fat decreasing effects of fenofibrate on alcoholic fatty liver and drug-induced fatty liver in rats.
  65. ncbi Portal lymphocytic infiltrate in alcoholic liver disease
    Magali Colombat
    Service Central d Anatomie Pathologique, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Hum Pathol 33:1170-4. 2002
    ..These results suggest that lymphocytes may play a role in the pathogenesis of alcohol-induced liver fibrosis...
  66. pmc Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
    Shigang Xiong
    Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MMR 402, Los Angeles, CA 90033 9141, USA
    Am J Physiol Gastrointest Liver Physiol 295:G512-21. 2008
    ..Our results suggest enhanced iron uptake as a mechanism of KC iron loading in ALD and demonstrate the ILI response as a function acquired by differentiated macrophages in humans and as a priming mechanism for ALD...
  67. ncbi Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats
    Taizo Sugimoto
    Department of Internal Medicine and Molecular Science, B5, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 36:157-62. 2002
    To elucidate the role of microsomal triglyceride transfer protein (MTP) in the pathogenesis of alcoholic fatty liver, the effects of ethanol on MTP activity and gene expression were investigated.
  68. ncbi Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology
    M M Skelly
    Division of Gastroenterology and Pathology, University Hospital, Queen's Medical Centre, Nottingham, UK
    J Hepatol 35:195-9. 2001
    ..Liver biopsy yields a range of liver diseases of diverse nature and extent. Liver diseases may be uncovered for which specific treatment is indicated...
  69. ncbi A voluntary oral-feeding rat model for pathological alcoholic liver injury
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
    Methods Mol Biol 447:11-31. 2008
    ....
  70. ncbi [Nonalcoholic and alcoholic steatohepatitis]
    Cristina Cijevschi Prelipcean
    Facultatea de Medicina, Institutul de Gastroenterologie si Hepatologie Iaşi, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
    Rev Med Chir Soc Med Nat Iasi 107:51-8. 2003
    ..These two entities need to be known not only by gastroenterologist, but also by general practitioners, endocrinologists, nutritionists and cardiologists...
  71. ncbi Clinical features and risk factors of patients with fatty liver in Guangzhou area
    Qi kui Chen
    Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat Sen University, 107 West Yanjiang Road, Guangzhou 510120, Guangdong Province, China
    World J Gastroenterol 10:899-902. 2004
    ..The large-scale clinical studies have not carried out yet in Guangzhou area. The aim of the present study was to investigate the clinical features and related risk factors of patients with fatty liver in Guangzhou area...
  72. ncbi Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    Feng Hong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 40:933-41. 2004
    ..In conclusion, long-term IL-6 administration ameliorates fatty livers and protects against warm ischemia/reperfusion fatty liver injury, suggesting the therapeutic potential of IL-6 in treating human fatty liver disease...
  73. ncbi Nonalcoholic steatohepatitis--a long-term follow-up study: comparison with alcoholic hepatitis in ambulatory and hospitalized patients
    Helena Cortez-Pinto
    Department of Medicine 2, Center of Nutrition and Metabolism FMUL, IMM, University Hospital of Santa Maria, Lisbon, Portugal
    Dig Dis Sci 48:1909-13. 2003
    ..In conclusion, alcoholic patients as a whole had a worse prognosis, yet the ambulatory subgroup had a prognosis similar to nonalcoholic patients...
  74. ncbi [Nonalcoholic steatohepatitis (NASH): therapeutic approaches]
    H P Buscher
    Medizinische Klinik II, DRK Kliniken Berlin Köpenick
    Dtsch Med Wochenschr 129:S60-2. 2004
  75. ncbi Development of alcoholic fatty liver and fibrosis in rhesus monkeys fed a low n-3 fatty acid diet
    Robert J Pawlosky
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Rockville, Maryland 20852, USA
    Alcohol Clin Exp Res 28:1569-76. 2004
    ..Various alcohol-feeding studies in animals have been used to model some of the symptoms that occur in liver disease in humans...
  76. ncbi Some novel insights into the pathogenesis of alcoholic steatosis
    M Raj Lakshman
    Lipid Research Laboratory 151T, VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Alcohol 34:45-8. 2004
    ..In contrast, dietary intake of omega-3 polyunsaturated fatty acids in moderation may have a protective effect against steatosis and alcoholic liver disease...
  77. ncbi Correlation of alcohol consumption with liver histological features in non-cirrhotic patients
    Loreta A Kondili
    Laboratorio di Virologia, Istituto Superiore di Sanita, Rome, Italy
    Eur J Gastroenterol Hepatol 17:155-9. 2005
    ..The aim of our study was to determine liver morphological features directly related to the mean lifetime daily alcohol intake (LTDAI) in non-cirrhotic patients...
  78. ncbi Clinical syndromes of alcoholic liver disease
    Masayuki Adachi
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dig Dis 23:255-63. 2005
    ..To understand the clinical syndromes of alcoholic liver disease, this review highlights the papers on both clinical and basic research of alcoholic liver disease, especially on steatosis, alcoholic hepatitis and fibrosis...
  79. ncbi The effect of processing on liver biopsy core size
    Thomas R Riley
    Department of Medicine, The Penn State Hershey Medical Center, M C 045, PO Box 850, Hershey, PA 17033, USA
    Dig Dis Sci 53:2775-7. 2008
    ..Liver biopsy is a valuable clinical tool, but for the interpretation to be meaningful a certain core size should be obtained. This study examines the changes the liver biopsy core undergoes during processing steps...
  80. ncbi Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Metab 7:187-8. 2008
    ....
  81. ncbi Advances in diagnosis and treatment of hepatic steatosis
    Xiaowei Zhao
    Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091
    J Tradit Chin Med 24:64-9. 2004
    ....
  82. ncbi [Alcoholic and non-alcoholic steatohepatitis]
    J F Dufour
    Institut für klinische Pharmakologie der Universität Bern
    Ther Umsch 61:505-12. 2004
    ..Therefore, similar pathogenetic mechanisms are supposed. However, therapeutic approaches are different. Treatment of choice in ASH is alcohol abstinence, that of NASH the reduction of insulin resistance, primarily by weight loss...
  83. pmc Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome
    Kjersti M Aagaard-Tillery
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City 84158 Utah, USA
    J Mol Endocrinol 41:91-102. 2008
    ..diet results in a threefold increase in fetal liver triglycerides and histologic correlates of non-alcoholic fatty liver disease...
  84. ncbi Serum apoptotic caspase activity as a marker of severity in HBeAg-negative chronic hepatitis B virus infection
    G V Papatheodoridis
    Second Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital of Athens, 114 Vas Sophias Ave, 115 27 Athens, Greece
    Gut 57:500-6. 2008
    In chronic hepatitis C and non-alcoholic fatty liver disease, apoptotic caspases are activated in liver, and serum caspase activity has been suggested as a sensitive marker of early liver injury...
  85. pmc Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats
    Osamah Hussein
    Internal Medicine A, Sieff Government Hospital, PO Box 1008, Safed 13100, Israel
    World J Gastroenterol 13:361-8. 2007
    To evaluate the effects of different types of dietary fats on the hepatic lipid content and oxidative stress parameters in rat liver with experimental non-alcoholic fatty liver disease (NAFLD).
  86. pmc Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease
    Yu Gang Wang
    Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai, China
    World J Gastroenterol 15:2329-35. 2009
    To evaluate the possible role of Tribble 3 (TRB3) in a rat model of non-alcoholic fatty liver disease (NAFLD) and its signal transduction mechanism.
  87. ncbi Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD)
    G L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Histol Histopathol 24:1161-9. 2009
    Animal models used to study the pathogenesis of non-alcoholic fatty liver disease (NAFLD) are, in general, either genetically altered, or fed with a diet that is extremely high in fat or carbohydrates...
  88. ncbi Obesity and non-alcoholic fatty liver disease in chronic hepatitis C
    Zobair M Younossi
    Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, Virginia 22042, USA
    J Clin Gastroenterol 38:705-9. 2004
    Superimposed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) may affect HCV-related fibrosis. We performed a study to determine the relationship between NAFLD and chronic hepatitis C.
  89. ncbi Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease
    Jong Eun Yeon
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea
    J Gastroenterol Hepatol 19:799-804. 2004
    Although the pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains poorly understood, metabolic syndrome associated with insulin resistance is the most reproducible factor in the development of NAFLD...
  90. ncbi Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease
    G Tarantino
    Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Italy
    J Biol Regul Homeost Agents 25:47-56. 2011
    Non-alcoholic fatty liver disease, characterized by hepatocyte apoptosis, is distinct in fatty liver and non-alcoholic steatohepatitis, the more severe form...
  91. ncbi Systemic symptoms in non-alcoholic fatty liver disease
    Julia L Newton
    Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle, UK
    Dig Dis 28:214-9. 2010
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in the Western world and the incidence of the disease is constantly increasing...
  92. ncbi Surgical treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease
    R A Weiner
    Department of Surgery, Krankenhaus Sachsenhausen, Frankfurt am Main, Germany
    Dig Dis 28:274-9. 2010
    ..risk factors for the development of hepatic steatosis, non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) in children and adults...
  93. ncbi [Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]
    Emil Fraenkel
    Bajcsy Zsilinszky Kórház, I Belgyógyászati Osztály, Budapest
    Orv Hetil 148:793-8. 2007
    Non-Alcoholic Fatty Liver Disease is an acquired metabolic disease of the liver caused by accumulation of triglycerides in hepatocytes that is followed by necrobiotic inflammatory reaction, fibrosis and cirrhosis...
  94. ncbi Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease
    K Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Gut 57:1583-91. 2008
    No effective drugs have been developed to date to prevent or treat non-alcoholic fatty liver disease (NAFLD), although diet modification and exercise to improve obesity have been attempted...
  95. ncbi Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 34:757-66. 2011
    Hyperuricemia has been associated with metabolic disorders. In this line recent studies observed an independent link between higher uric acid serum levels and clinical diagnosis of non-alcoholic fatty liver disease (NAFLD).
  96. ncbi Safety and efficacy of combined ezetimibe/simvastatin treatment and simvastatin monotherapy in patients with non-alcoholic fatty liver disease
    Tatjana Abel
    Outpatient Department, National Health Centre, Budapest, Hungary
    Med Sci Monit 15:MS6-11. 2009
    Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases all over the world. In patients with a high cardiovascular risk the decrease of cholesterol level is especially important...
  97. ncbi Non-alcoholic fatty liver disease and the metabolic syndrome in an urban hospital serving an African community
    Charles Asabamaka Onyekwere
    Gastroenterology Unit, Lagos State University Teaching Hospital, Nigeria
    Ann Hepatol 10:119-24. 2011
    ..However non-alcoholic fatty liver disease may be an important contributory factor...
  98. ncbi The clinical aspects of non-alcoholic fatty liver disease
    E Bjornsson
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Minerva Gastroenterol Dietol 54:7-18. 2008
    Non-alcoholic fatty liver disease (NAFLD) has been increasingly recognized as the most common pathological conditions affecting the liver...
  99. pmc Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?
    Giovanni Tarantino
    Federico II University Medical School of Naples, Department of Clinical and Experimental Medicine, Naples, Italy
    J Transl Med 6:72. 2008
    Inside the spectrum of non-alcoholic fatty liver disease, simple fatty liver is generally thought of as being "non progressive", differently from non-alcoholic steatohepatitis, which increases in severity due to the presence of apoptosis/..
  100. ncbi The prevalence of celiac disease among patients with non-alcoholic fatty liver disease in Iran
    Ali Reza Rahimi
    GI and Hepatology Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Islamic Republic of, Iran
    Turk J Gastroenterol 22:300-4. 2011
    Some patients with non-alcoholic fatty liver disease have no obesity-related etiologies. Celiac disease could potentially present with elevated liver enzymes and chronic liver disease...
  101. pmc The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease
    Valerio Nobili
    Department of Hepatogastroenterology and Nutrition, Pediatric Hospital IRCCS Bambino Gesù, Via S, Onofrio 4, 00165 Rome, Italy
    BMC Med 7:21. 2009
    Liver fibrosis is a stage of non-alcoholic fatty liver disease (NAFLD) which is responsible for liver-related morbidity and mortality in adults...

Research Grants71

  1. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..In addition to chronic HBV, other chronic liver disease etiologies including chronic hepatitis C, non- alcoholic fatty liver disease and autoimmune hepatitis have been shown to cause substantial morbidity and mortality among Alaska ..
  2. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..with metabolic syndrome have increased hepatic triglycerides (TG) (steatosis) that predisposes them to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) for which there is no consensus treatment...
  3. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Hepatic steatosis directly contributes to insulin resistance and non-alcoholic fatty liver disease (NAFLD)...
  4. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Obese humans with diabetes (NIDDM), metabolic syndrome (MetS) or non-alcoholic fatty liver disease (NAFLD), however, have low a low ratio of 20:4w6 relative to 18:2w6 in plasma and liver when ..
  5. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..mechanistic insights into the pathophysiology of dyslipidemia and other metabolic diseases including non-alcoholic fatty liver disease (NAFLD)...
  6. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary Alcoholic liver diseases (ALD) -- ranging from alcoholic fatty liver to alcohol-induced liver fibrosis and cirrhosis - - account for more than 50% of all chronic liver diseases in ..
  7. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are rapidly becoming the commonest reason patients in the United States seek advice from a gastroenterologist...
  8. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in Veterans and its prevalence continues to increase, with the growing obesity epidemic...
  9. Hepatic Steatosis and ER Stress-Inducible Transcription Factor CREBH
    Kezhong Zhang; Fiscal Year: 2013
    ..provided by applicant): Hepatic steatosis or fatty liver is considered the key metabolic precursor to non-alcoholic fatty liver disease (NAFLD), the major cause of liver-associated illness and death in the United States...
  10. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..on the interaction between lipid metabolism and chronic liver disease, specifically hepatitis C and non-alcoholic fatty liver disease (NAFLD)...
  11. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is the most common chronic pediatric liver disease and may progress to an aggressive necro-inflammatory disease (NASH) that leads to fibrosis and cirrhosis ..
  12. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..Obese Latino children exhibit the highest prevalence of dyslipidemia, visceral adiposity, and non-alcoholic fatty liver disease (NAFLD);African American children present instead with hypertension, worsened insulin resistance, ..
  13. Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2
    David E Cohen; Fiscal Year: 2013
    ..insulin resistance due to obesity is central to the pathogenesis of common disorders including non- alcoholic fatty liver disease (NAFLD)...
  14. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..the development of obesity-induced adipocyte dysfunction and complications, including type 2 diabetes, non-alcoholic fatty liver disease and dyslipidemia...
  15. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    ..Both are associated with significant levels of morbidity and mortality;they are leading causes of non-alcoholic fatty liver disease, blindness, kidney failure and non-traumatic amputations, and these patients are also at increased ..
  16. Inactivation of Hdac3 in the cause, prevention, and treatment of HCC
    Scott W Hiebert; Fiscal Year: 2013
    ..Removal of Hdac3 in the mouse liver caused a phenotype similar to non-alcoholic fatty liver disease, which was likely due to de- regulated nuclear hormone receptor functions...
  17. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..obesity;CREB and activated NF- B2 levels were increased in the livers of mice with obesity and humans with alcoholic fatty liver disease or hepatitis C...
  18. Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose Tissue
    David E Cohen; Fiscal Year: 2013
    ..of insulin resistance and obesity, is central to the pathogenesis of common disorders including non-alcoholic fatty liver disease (NAFLD)...
  19. Mechanisms and metabolic implications of LRP130 in NAFLD
    Marcus P Cooper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States...
  20. MLK3 in metabolic stress signaling
    Anja Jaeschke; Fiscal Year: 2013
    ..that is associated with metabolic syndrome, including insulin resistance and the development of non-alcoholic fatty liver disease (NAFLD)...
  21. NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment
    Kenneth Cusi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition characterized by insulin resistance and hepatic fat accumulation (steatosis)...
  22. Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver disease
    Frank A Anania; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a major health concern among US veterans...
  23. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
    ..The third aim is to determine how chronic ER stress contributes to pathological steatosis, in particular alcoholic fatty liver disease...
  24. Mechanisms of Lipid-Induced Hepatic Insulin Resistance
    Gerald I Shulman; Fiscal Year: 2013
    ..Recent studies in both humans and rodent models of non alcoholic fatty liver disease (NAFLD) have led to a unifying diacylglycerol-hypothesis (DAG-hypothesis) for lipid-induced ..
  25. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe phenotype, non-alcoholic steatohepatitis (NASH), are increasing significantly in the United States in the adult and pediatric ..
  26. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    ..b>Alcoholic fatty liver disease, or steatosis, is one of the earliest and most common consequences of excess alcohol consumption ..
  27. Pathogenic Mechanisms of Fatty Liver Disease
    Mohammad S Siddiqui; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disorders (NAFLD) are the most common cause of abnormal serum liver chemistry tests in the United States and are the leading causes of cryptogenic cirrhosis...
  28. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2009
    ..AICAR), an activator of AMPK, enhances ureagenesis in a rat model of non-alcoholic fatty liver disease and in the obese Zucker rat, a model of MS...
  29. Regulation of Hepatic Glucose Homeostasis by Phosphatidylcholine Transfer Protein
    Baran Ersoy; Fiscal Year: 2012
    ..to insulin action is the primary pathophysiological defect that predisposes to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD)...
  30. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..Preliminary studies show an increased burden of metastatic disease in a mouse model of diet-induced non-alcoholic fatty liver disease (NAFLD)...
  31. Glycerolipid synthesis in liver
    ROSALIND ANNE COLEMAN; Fiscal Year: 2013
    ..Non-alcoholic fatty liver disease is a frequent prelude to fibrosis, cirrhosis and hepatocellular carcinoma, and the presence of TAG ..
  32. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2013
    ..develop and validate non-invasive quantitative methods for early diagnosis and quantitative grading of Non-Alcoholic Fatty Liver Disease (NAFLD), using magnetic resonance imaging (MRI)...
  33. NOVEL MODULATORS OF ALCOHOL INDUCED METABOLIC AND LIVER INJURY
    Raj M Lakshman; Fiscal Year: 2013
    ..i) PGC1beta seems to play a secondary role because PGC1beta-KO mice still developed alcoholic fatty liver albeit less pronounced than in PGC11-KO mice, presumably because of ethanol-mediated strong inhibition of ..
  34. Enhancement of NAFLD risk by vinyl chloride: interaction of gut-liver-adipose axi
    JULIANE INGEBORG BEIER; Fiscal Year: 2013
    ..A major disease associated with obesity is non-alcoholic fatty liver disease (NAFLD)...
  35. Genome-wide SNP association in psoriasis
    ANNE MARY BOWCOCK; Fiscal Year: 2012
    ..conditions such as obesity, metabolic syndrome, diabetes, cardiovascular disease, renal failure, non-alcoholic fatty liver disease, Crohn's disease, hypertension, stroke, and hypertension...
  36. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..With the dramatic increased prevalence of non-alcoholic fatty liver disease and chronic hepatitis C worldwide, it is expected that the health care impact and cost of liver ..
  37. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2013
    ..that down- regulation of adiponectin production has patho-physiological importance in the process of alcoholic fatty liver disease;however, the underlying mechanisms are still elusive...
  38. Hepatocyte Clock and Alcoholic Fatty Liver Injury
    SHANNON MARIE BAILEY; Fiscal Year: 2011
    ....
  39. A Genetic Model for Understanding the Metabolic Syndrome/Obesity Relationship
    BENJAMIN JENNINGS RENQUIST; Fiscal Year: 2010
    ..Metabolic syndrome associated disorders include non-insulin dependent diabetes mellitus (NIDDM), non-alcoholic fatty liver disease, hypertension, and heart disease...
  40. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
    ..Insulin resistance that develops in the liver as a consequence of obesity is known as non-alcoholic fatty liver disease (NAFLD) and is characterized by the liver's inability to suppress glucose synthesis and to ..
  41. Treatment of Alcohol Induced Hepatic Injury with REV-ERB Ligands
    Thomas P Burris; Fiscal Year: 2013
    ..liver) to cirrhosis and patients with ALD also may share risk factors for simultaneous injury from non-alcoholic fatty liver disease (NAFLD), which is a significant concern given its association with high fat diets and obesity ..
  42. Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
    Gerhard Wagner; Fiscal Year: 2013
    ..such as insulin resistance, obesity, elevated LDL-C and triglycerides, cardiovascular pathologies, and non-alcoholic fatty liver disease...
  43. Effects of ethanol on lipid metabolism
    Min You; Fiscal Year: 2013
    ..effects to occur, as ethanol metabolism has also been unequivocally associated with the development of alcoholic fatty liver disease...
  44. The Role of Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease
    Jeffrey D Browning; Fiscal Year: 2013
    ..by applicant): Mitochondrial dysfunction may be responsible for the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD), a condition that affects over 71 million individuals in the U.S. alone...
  45. LIPIN 1 IN THE REGULATION OF HEPATIC LIPID METABOLISM
    Brian N Finck; Fiscal Year: 2013
    ..Overwhelming evidence links obesity with increased risk for several chronic diseases including non- alcoholic fatty liver disease (NAFLD)...
  46. Determining the Function of PNPLA3 Utilizing Metabolomics and Stable Isotope Labe
    MATTHEW ALVIN MITSCHE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent medical problem that affects approximately a third of the US population...
  47. Mechanisms of Brd2 immunoprotection from insulin resistance
    Gerald V Denis; Fiscal Year: 2011
    ..wide-ranging, health-related impacts of obesity include cardiovascular disease, metabolic syndrome, non-alcoholic fatty liver disease, some forms of cancer, and Type 2 diabetes in particular, which is a disorder of insulin ..
  48. Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease
    Stanley L Hazen; Fiscal Year: 2013
    ..the development of complex dysmetabolic phenotypes, such as susceptibility to insulin resistance and non-alcoholic fatty liver disease...
  49. Hepatic Steatosis and the Lipid Metabolome
    GHULAM A S ANSARI; Fiscal Year: 2012
    ..steatosis (fatty liver) is an early and reversible stage of both alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), which are major causes of liver-associated illness and death...
  50. Adipose Tissue Lipolysis and Alcoholic Fatty Liver
    Zhanxiang Zhou; Fiscal Year: 2013
    Adipose tissue lipolysis and alcoholic fatty liver Project Summary Alcoholic fatty liver is one of the earliest pathological changes in the progression of alcoholic liver disease...
  51. Functional characterization of a novel gene for non-alcoholic fatty liver disease
    ALEXIS L GORDEN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is the most common cause of end-stage liver disease in the developed world;two-thirds of the obese develop NAFLD and are at risk for developing cirrhosis, ..
  52. Nano-Antioxidants as a Therapeutic for Preclinical Models of NAFLD
    Robia G Pautler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases, ranging from simple steatosis (fat in the liver) to non-alcoholic steatohepatitis (NASH) to cirrhosis...
  53. Assembly and Secretion of ApoB Containing Lipoproteins
    Henry N Ginsberg; Fiscal Year: 2013
    ..Recently, hepatic steatosis, or non-alcoholic fatty liver disease (NAFLD), has emerged as an additional component of the phenotype...
  54. Regulation of Alcohol-induced Fatty Liver Disease by Lipid Droplet Trafficking
    MARK A MC NIVEN; Fiscal Year: 2010
    ..Alcohol abuse and alcohol-induced liver disease are a major health concern in the US and worldwide. Alcoholic fatty liver disease (AFLD) is marked by the aberrant accumulation of intracellular fatty acids in hepatocytes and can ..
  55. Adipokine Signaling in Macrophages
    Ling Qi; Fiscal Year: 2013
    ..of medically important complications, particularly atherosclerosis, cancer, insulin resistance and non-alcoholic fatty liver disease...
  56. Hepatic Myeloid Cells Regulated by Obesity
    Amrom E Obstfeld; Fiscal Year: 2011
    ..the inflammatory process induced by obesity in the liver and how it contributes to the pathogenesis of Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus...
  57. TORS - Interdisciplinary Research Training Program, Project 8 of 10 RL9
    Joyce J Repa; Fiscal Year: 2011
    ..our society, contributing to diabetes mellitus, cardiovascular disease and stroke, hypertension, and non-alcoholic fatty liver disease...
  58. Intestinal bacterial metagenome in pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe phenotype, non-alcoholic steatohepatitis (NASH), are increasing significantly in the United States in the adult and ..
  59. Translational Systems Genetics of Mitochondria, Metabolism, and Aging
    Robert W Williams; Fiscal Year: 2013
    ..Type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, hyperlipidemia, and cardiovascular diseases are all linked to major changes in ..
  60. The pathogenesis of insulin resistance in alcoholic liver disease
    Rotonya M Carr; Fiscal Year: 2013
    ..program focused on developing a lipid signature that can be used to predict disease prognosis in patients with both ALD and non-alcoholic fatty liver and identify insulin signaling targets that can ultimately be used therapeutically.
  61. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2012
    ..poses an increased risk of developing many secondary conditions, including atherosclerosis, diabetes, non-alcoholic fatty liver disease, periodontal disease, certain cancers, and asthma...
  62. A novel role for p53 in congenital disorders of glycosylation
    Jaime Chu; Fiscal Year: 2013
    ..I will then apply this knowledge to more common causes of these same diseases in pediatric patients, as non-alcoholic fatty liver disease, fibrosis, and cirrhosis are all associated with defects in protein glycosylation.
  63. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..CRN) to develop a rapid, non-invasive and inexpensive diagnostic assay to detect and possibly stage non-alcoholic fatty liver disease (NAFLD)...
  64. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..Obesity and the metabolic syndrome are an epidemic in the United States. Non-alcoholic fatty liver disease (NAFLD), which is associated with the metabolic syndrome, now represents the most common cause of ..
  65. Priming of liver disease by arsenic exposure
    Gavin E Arteel; Fiscal Year: 2010
    ..the hypothesis that low-dose arsenic exposure sensitizes liver to hepatotoxicity in mouse models of non alcoholic fatty liver disease (NAFLD). A liver disease that is currently endemic to the US population is obesity-induced NAFLD...
  66. Alternative human cell-based models of fatty liver disease
    Bentley Cheatham; Fiscal Year: 2010
    ..In parallel with the increasing incidence of obesity and insulin resistance, is the occurrence of non-alcoholic fatty liver disease (NAFLD), a chronic hepatic disorder affecting up to 25% of the general population;including a ..
  67. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    ELIZABETH SPELIOTES; Fiscal Year: 2007
    ..increase in obesity has been accompanied by an increase in diabetes, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). NAFLD can result in liver cirrhosis and eventual liver failure...
  68. EFFECTS OF ETHANOL ON HEPATIC ORGANIC ANION UPTAKE
    Barry Potter; Fiscal Year: 1992
    ..Although pigment gallstone formation and alcoholic fatty liver are associated with chronic alcohol abuse, the exact role of alcohol in their manifestation is unknown...
  69. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..The primary long-term objective of this proposal is to determine the epidemiology and genetics of non-alcoholic fatty liver (NAFLD)...
  70. Fatty Liver Disease and Hepatic Energy Homostatis in SH*
    Jeanne Clark; Fiscal Year: 2005
    ..resistance, diabetes mellitus, hypertension, and dyslipidemia; less well known is its association with non-alcoholic fatty liver disease (NAFLD)...
  71. BIOENERGETIC ASPECTS OF ALCOHOL CONSUMPTION
    William Thayer; Fiscal Year: 1991
    ..Rats fed ethanol chronically will be used as an animal model for alcoholic fatty liver. Isolated hepatocytes, liver mitochondria, phosphorylating submitochondrial particles, and phospholipid ..