fatty liver

Summary

Summary: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Top Publications

  1. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
  2. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  3. ncbi Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
  4. ncbi Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
  5. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
  6. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
  7. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
  8. doi Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    G Vernon
    Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Aliment Pharmacol Ther 34:274-85. 2011
  9. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
  10. pmc Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hepatology 51:679-89. 2010

Detail Information

Publications364 found, 100 shown here

  1. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD...
  2. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  3. ncbi Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), its pathogenesis and clinical significance remain poorly defined...
  4. ncbi Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
    Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin-resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set...
  5. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
    Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries...
  6. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
    ..m(-2). min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2)...
  7. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage...
  8. doi Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    G Vernon
    Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Aliment Pharmacol Ther 34:274-85. 2011
    Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, and its worldwide prevalence continues to increase with the growing obesity epidemic...
  9. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
    ..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease...
  10. pmc Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hepatology 51:679-89. 2010
    Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD)...
  11. ncbi The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:113-21. 2005
    The natural history of nonalcoholic fatty liver disease (NAFLD) in the community remains unknown. We sought to determine survival and liver-related morbidity among community-based NAFLD patients.
  12. doi Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    Christopher D Williams
    Gastroenterology and Hepatology Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, USA
    Gastroenterology 140:124-31. 2011
    Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH).
  13. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established.
  14. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
    Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3...
  15. doi Nonalcoholic fatty liver disease: a review and update
    Jeffrey R Lewis
    Department of Medicine, Center for Liver Diseases, University of Chicago, Chicago, IL 60637, USA
    Dig Dis Sci 55:560-78. 2010
    The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis...
  16. ncbi Long-term follow-up of patients with NAFLD and elevated liver enzymes
    Mattias Ekstedt
    Division of Gastroenterology and Hepatology, Department of Molecular and Clinical Medicine, University Hospital, Linkoping, Sweden
    Hepatology 44:865-73. 2006
    Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver enzymes in patients of developed countries. We determined the long-term clinical and histological courses of such patients...
  17. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
    ..Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis...
  18. ncbi Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    A J Sanyal
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia 23298 0711, USA
    Gastroenterology 120:1183-92. 2001
    ....
  19. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
    Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes...
  20. ncbi Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:32345-53. 2004
    ..high fat feeding in rats results specifically in hepatic fat accumulation and provides a model of non-alcoholic fatty liver disease in which to study the mechanism of hepatic insulin resistance...
  21. doi Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 52:774-88. 2010
    ....
  22. doi Causes and metabolic consequences of Fatty liver
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Endocr Rev 29:939-60. 2008
    ..and particularly visceral adiposity are established risk factors for these diseases, in the recent years fatty liver emerged as an additional and independent factor...
  23. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
    ..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
  24. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  25. ncbi Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    Geoffrey C Farrell
    The Storr Liver Unit, Westmead s Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Hepatology 43:S99-S112. 2006
    ..Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981...
  26. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the western world. It is now recognized that these patients have myriad of important co-morbidities (e.g...
  27. pmc Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    Nitika Arora Gupta
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hepatology 51:1584-92. 2010
    ..Small interfering RNA against GLP-1R abolished the effects on PDK-1 and PKC-zeta. Treatment with exendin-4 quantitatively reduced triglyceride stores compared with control-treated cells...
  28. pmc Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    Naoki Kumashiro
    Howard Hughes Medical Institute and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 108:16381-5. 2011
    Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes...
  29. ncbi Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    Giorgio Bedogni
    Centro Studi Fegato, Area Science Park, Basovizza, and Department of BBCM, University of Trieste, Italy
    Hepatology 42:44-52. 2005
    The prevalence of and the risk factors for fatty liver have not undergone a formal evaluation in a representative sample of the general population...
  30. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
    Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups...
  31. doi Non-alcoholic fatty liver disease: the mist gradually clears
    Nimantha Mark Wilfred de Alwis
    Liver Group, Institute of Cellular Medicine, Newcastle University, United Kingdom
    J Hepatol 48:S104-12. 2008
    Non-alcoholic fatty liver disease (NAFLD) is now the commonest liver disorder in the developed world affecting up to a third of individuals...
  32. pmc The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study
    Neeraj Bhala
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Hepatology 54:1208-16. 2011
    Information on the long-term prognosis of nonalcoholic fatty liver disease (NAFLD) is limited...
  33. ncbi Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, MO 63110, USA
    Hepatology 37:1202-19. 2003
    b>Fatty liver disease that develops in the absence of alcohol abuse is recognized increasingly as a major health burden...
  34. pmc A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    Shaoqing He
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6706-15. 2010
    ..These data are consistent with PNPLA3-I148M promoting triglyceride accumulation by limiting triglyceride hydrolysis...
  35. ncbi Fatty liver: a novel component of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 28:27-38. 2008
    ..is not attributable to alcohol or other known causes of liver disease, a condition defined as nonalcoholic fatty liver disease (NAFLD) by gastroenterologists. The fatty liver is insulin resistant...
  36. ncbi Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines
    Shivakumar Chitturi
    Gastroenterology and Hepatology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Garran, Australia
    J Gastroenterol Hepatol 22:778-87. 2007
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western industrialized countries, affecting 20-40% of the general population...
  37. ncbi Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    Janardan K Reddy
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
    Am J Physiol Gastrointest Liver Physiol 290:G852-8. 2006
    b>Fatty liver disease (FLD), whether it is alcoholic FLD (AFLD) or nonalcoholic FLD (NAFLD), encompasses a morphological spectrum consisting of hepatic steatosis (fatty liver) and steatohepatitis...
  38. doi Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    Hepatology 52:1836-46. 2010
    Whereas in most cases a fatty liver remains free of inflammation, 10%-20% of patients who have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). Inflammation may precede steatosis in certain instances...
  39. pmc Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    Quentin M Anstee
    Department of Medicine A, St Mary s Campus, Imperial College, London, UK
    Int J Exp Pathol 87:1-16. 2006
    Non-alcoholic fatty liver disease (NAFLD) represents a histological spectrum of liver disease associated with obesity, diabetes and insulin resistance that extends from isolated steatosis to steatohepatitis and cirrhosis...
  40. doi Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    Anabela P Rolo
    Center for Neuroscience and Cell Biology, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 52:59-69. 2012
    ..rising prevalence of obesity and insulin resistance is associated with a parallel increase in nonalcoholic fatty liver disease (NAFLD)...
  41. doi Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease
    Anna Alisi
    Unit of Metabolic and Autoimmune Liver Diseases, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Lab Invest 91:283-93. 2011
    Nonalcoholic fatty liver disease (NAFLD) is an emerging disease with a broad spectrum of liver conditions. The complex molecular pathogenesis of NAFLD is still unclear...
  42. doi From the metabolic syndrome to NAFLD or vice versa?
    Ester Vanni
    Division of Gastro Hepatology, San Giovanni Battista Hospital, University of Turin, c so Bramante 88, 10126 Turin, Italy
    Dig Liver Dis 42:320-30. 2010
    ..Nonalcoholic fatty liver disease (NAFLD) comprises a disease spectrum which includes variable degrees of simple steatosis (nonalcoholic ..
  43. pmc Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    Tsuguhito Ota
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:316-32. 2008
    ..These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis...
  44. ncbi Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Santiago, Chile
    Clin Sci (Lond) 106:635-43. 2004
    Hepatic steatosis is a major feature associated with NAFLD (non-alcoholic fatty liver disease)...
  45. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation...
  46. ncbi Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
    Hae Jin Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Arch Intern Med 164:2169-75. 2004
    Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults...
  47. ncbi The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    Masahide Hamaguchi
    Department of Gastroenterology, Asahi University, Murakami Memorial Hospital, Gifu, Japan
    Ann Intern Med 143:722-8. 2005
    The frequent association of nonalcoholic fatty liver disease with components of the metabolic syndrome such as obesity, hyperglycemia, dyslipidemia, and hypertension is well known...
  48. ncbi Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    Vlad Ratziu
    Service d Hepatogastroenterologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Gastroenterology 128:1898-906. 2005
    In nonalcoholic fatty liver disease (NAFLD), the distinction between steatosis and steatohepatitis (NASH) and the assessment of the severity of the disease rely on liver histology alone...
  49. doi Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    Giovanni Musso
    Gradenigo Hospital, 10132 Turin, Italy
    Prog Lipid Res 48:1-26. 2009
    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and is considered the hepatic manifestation of metabolic syndrome...
  50. pmc Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 53:810-20. 2011
    ..A separate system of scoring the features of nonalcoholic fatty liver disease (NAFLD) called the NAFLD Activity Score (NAS) was developed as a tool to measure changes in NAFLD ..
  51. doi Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
    Paulina Pettinelli
    Department of Food Science, Nutrition, and Dietetics, Faculty of Pharmacy, University of Concepcion, Casilla 237, Concepcion, Chile
    J Clin Endocrinol Metab 96:1424-30. 2011
    Triglyceride accumulation in the liver is an early feature in the development of nonalcoholic fatty liver disease (NAFLD) associated with human obesity, which is a multifactorial syndrome and whose underlying mechanisms are beginning to ..
  52. pmc Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    Ya Wen Teng
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:36258-67. 2011
    ..A lack of Bhmt also affects susceptibility to fatty liver and hepatocellular carcinoma...
  53. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance...
  54. ncbi Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
    Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal bacterial overgrowth and overexpress tumor necrosis factor alpha (TNF-alpha)...
  55. pmc Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1072-8. 2009
    ..Our cohort consisted of 139 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) from eight CRN participant centers across the United States and 150 age-matched healthy ..
  56. pmc PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 52:904-12. 2010
    ..In this study we aim to test whether these SNPs influence the risk of histologically-confirmed nonalcoholic fatty liver disease (NAFLD)...
  57. doi Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 72076 Tubingen, Germany
    J Hepatol 51:433-45. 2009
    ..The two most common conditions associated with fatty liver are alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD)...
  58. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology...
  59. ncbi Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Hepatology 33:1358-64. 2001
    ..05). Our data indicate that steatosis is an important cofactor in increasing liver necroinflammatory activity and in accelerating fibrosis in CHC. Visceral obesity and genotype 3a play a role in the development of steatosis...
  60. doi Adipokines in liver diseases
    Fabio Marra
    Department of Internal Medicine, University of Florence, Florence, Italy
    Hepatology 50:957-69. 2009
    ..Several studies have investigated plasma levels of adiponectin in patients with nonalcoholic fatty liver disease, to establish correlations with the underlying state of insulin resistance and with the type and ..
  61. pmc Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    Silvia Cermelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e23937. 2011
    ..In both CHC and NAFLD patient groups, serum levels of miR-122 and miR-34a correlated with liver enzymes levels, fibrosis stage and inflammation activity. miR-122 levels also correlated with serum lipids in NAFLD patients...
  62. doi Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    Kristiaan Wouters
    Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands
    Hepatology 48:474-86. 2008
    ..Omitting cholesterol from the HFC diet lowered plasma VLDL cholesterol and prevented the development of inflammation and hepatic foam cells...
  63. doi Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
    Amalia Gastaldelli
    Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hepatology 50:1087-93. 2009
    ..02 versus placebo). Adipo-IR decreased by 47% and correlated with the reduction of hepatic fat (r=0.46, P=0.009) and with the reduction in hepatic necroinflammation (r=0.47, P=0.0007)...
  64. doi Epidemiology of non-alcoholic fatty liver disease in China
    Jian Gao Fan
    Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    J Hepatol 50:204-10. 2009
    b>Fatty liver (steatosis) is highly prevalent in China and is more often linked to obesity than to alcoholism. Among more affluent regions of China, the community prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 15%...
  65. ncbi Prevalence of and risk factors for fatty liver in a general population of Shanghai, China
    Jian Gao Fan
    Center for Fatty Liver, Shanghai First People s Hospital, Jiaotong University, Shanghai, China
    J Hepatol 43:508-14. 2005
    To determine the prevalence and risk factors of fatty liver (FL) among Shanghai adults.
  66. doi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    It is uncertain whether patients with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder disease and should undergo liver biopsy...
  67. ncbi Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    Ariel E Feldstein
    Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 40:185-94. 2004
    Nonalcoholic fatty liver disease (NAFLD) is a serious health problem. Although NAFLD represents a form of lipotoxicity, its pathogenesis remains poorly understood...
  68. ncbi Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    Kanji Yamaguchi
    Division of Gastroenterology, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hepatology 45:1366-74. 2007
    In the early stages of nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate in hepatocytes. Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in hepatocyte triglyceride biosynthesis...
  69. pmc GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    Hélène L Kammoun
    INSERM, UMR S, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 119:1201-15. 2009
    ..These findings demonstrate that GRP78 inhibits both insulin-dependent and ER stress-dependent SREBP-1c proteolytic cleavage and explain the role of ER stress in hepatic steatosis in obese rodents...
  70. pmc Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    Harmeet Malhi
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    Semin Liver Dis 28:360-9. 2008
    Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs)...
  71. pmc Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 51:1979-87. 2010
    ..Specific patterns of body fat distribution, in particular fatty liver, may preferentially predispose at-risk individuals to disease...
  72. doi The epidemiology of nonalcoholic fatty liver disease: a global perspective
    Mariana Lazo
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Semin Liver Dis 28:339-50. 2008
    Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver disease in the United States and worldwide...
  73. doi Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    Kimberley D Bruce
    Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Hepatology 50:1796-808. 2009
    Nonalcoholic fatty liver disease (NAFLD) describes an increasingly prevalent spectrum of liver disorders associated with obesity and metabolic syndrome...
  74. doi Kupffer cell activation is a causal factor for hepatic insulin resistance
    Nicolas Lanthier
    Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Ave Mounier 53, B 1200 Brussels, Belgium
    Am J Physiol Gastrointest Liver Physiol 298:G107-16. 2010
    ....
  75. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ..study was performed to (1) characterize the clinical and histologic features of those with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) values, (2) compare the spectrum of NAFLD associated ..
  76. ncbi The epidemiology of nonalcoholic fatty liver disease in adults
    Jeanne M Clark
    Department of Medicine and Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Gastroenterol 40:S5-10. 2006
    Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that has been shown to progress to cirrhosis and hepatocellular carcinoma...
  77. pmc Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
    I J Hickman
    School of Medicine, University of Queensland, and Department of Nutrition and Dietetic Services, Princess Alexandra Hospital, Brisbane, Australia
    Gut 53:413-9. 2004
    Obesity is a risk factor for progression of fibrosis in chronic liver diseases such as non-alcoholic fatty liver disease and hepatitis C...
  78. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis...
  79. pmc Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Clin Invest 117:739-45. 2007
    Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance and type 2 diabetes mellitus, but the molecular signals linking hepatic fat accumulation to hepatic insulin resistance are unknown...
  80. ncbi Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance
    Michael Roden
    First Medical Department 1 Diabetology, Gastroenterology, Nephrology, Hanusch Hospital, Heinrich Collin Strasse 30, A 1140 Vienna, Austria
    Nat Clin Pract Endocrinol Metab 2:335-48. 2006
    ..In conclusion, liver fat is a critical determinant of metabolic fluxes and inflammatory processes, thereby representing an important therapeutic target in insulin resistance and type 2 diabetes mellitus...
  81. pmc Sirt1 protects against high-fat diet-induced metabolic damage
    Paul T Pfluger
    Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:9793-8. 2008
    ..Together, these results provide direct proof of the protective potential of Sirt1 against the metabolic consequences of chronic exposure to a high-fat diet...
  82. doi Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    Hepatology 51:454-62. 2010
    Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Accurate noninvasive tests for liver injury are urgently needed...
  83. pmc Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    Dima L Diab
    Department of Endocrinology, Cleveland Clinic, Cleveland, Ohio, USA
    Clin Gastroenterol Hepatol 6:1249-54. 2008
    Nonalcoholic fatty liver disease (NAFLD) is extremely common among morbidly obese patients. We assessed the usefulness of plasma caspase-generated cytokeratin 18 (CK-18) fragments as a novel marker for NAFLD in a bariatric cohort.
  84. doi Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    Anna Wieckowska
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Gastroenterol 103:1372-9. 2008
    Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are growing public health problems, and are strongly associated. The link between the two conditions remains poorly understood...
  85. ncbi Fatty liver and the metabolic syndrome among Shanghai adults
    Jian Gao Fan
    Center for Fatty Liver, Shanghai First People s Hospital Affiliated JiaoTong University, Shanghai, China
    J Gastroenterol Hepatol 20:1825-32. 2005
    To explore the relationship between fatty liver and the metabolic syndrome in the adults of Shanghai and evaluate the value of fatty liver as a marker for risk factor clustering.
  86. doi The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
    Stefano Romeo
    Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
    J Hepatol 53:335-8. 2010
    Childhood obesity is a growing problem worldwide. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children...
  87. doi The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    Mustafa S Ascha
    Department of Gastroenterology and Hepatology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 51:1972-8. 2010
    ..Compared with nondrinkers, patients who reported any regular alcohol consumption were at greater risk for HCC development (hazard ratio: 3.6; P25, P75: 1.5, 8.3)...
  88. doi Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
    Jude A Oben
    University College London, Centre for Hepatology, Royal Free Hospital, London, UK
    J Hepatol 52:913-20. 2010
    Obesity induced, non-alcoholic fatty liver disease (NAFLD), is now the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide...
  89. ncbi Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease
    S H Caldwell
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA
    Hepatology 29:664-9. 1999
    ..Although there is some diversity that indicates more than one cause, our findings suggest that NASH plays an under-recognized role in many patients with cryptogenic cirrhosis, most of whom are older, type 2 diabetic and obese females...
  90. pmc Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Hepatology 52:1134-42. 2010
    ..rs738409(G) allele of the PNPLA3 gene was found to be strongly associated with both nonalcoholic and alcoholic fatty liver disease. We have generated Pnpla3(-/-) mice by gene targeting...
  91. pmc Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients
    Adeline Bertola
    INSERM U895, Team 8 Hepatic complications of obesity, Nice, France
    PLoS ONE 5:e13577. 2010
    ..We aimed at identifying expression patterns of inflammatory and immune response genes specifically associated with obesity and NASH in the liver of morbidly obese patients...
  92. pmc Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 362:1082-9. 2010
    Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and type 2 diabetes mellitus. Whether this association has a genetic basis is unknown.
  93. ncbi The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients
    Claudio C Mottin
    Centro da Obesidade Mórbida, Hospital São Lucas PUCRS, Porto Alegre, Brazil
    Obes Surg 14:635-7. 2004
    ..We evaluated the importance of ultrasound in the diagnosis of steatosis in morbidly obese patients, and considered its clinical relevance for patients with BMI of 35-40 kg/m(2) without co-morbidities...
  94. ncbi AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fibrosis
    Aurora Loaeza-del-Castillo
    Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Ann Hepatol 7:350-7. 2008
    ..to validate, in a Mexican tertiary health care setting, the diagnostic usefulness of APRI in CHC, nonalcoholic fatty liver disease (NAFLD) and autoimmune hepatitis (AIH)...
  95. ncbi [Non-alcoholic fatty liver disease: a new challenge for cardiologists]
    Roberto Tarquini
    Dipartimento di Medicina Interna, Azienda Ospedaliero Universitaria Careggi, Firenze
    G Ital Cardiol (Rome) 11:660-9. 2010
    The prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 17% to 33% in the general population...
  96. ncbi Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Gastroenterology 121:91-100. 2001
    Nonalcoholic fatty liver disease (NAFLD) is common in severely obese subjects and can progress to cirrhosis and liver failure...
  97. ncbi The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the highest risk for progressing to end-stage liver disease...
  98. ncbi Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    Ariel E Feldstein
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905 USA
    Gastroenterology 125:437-43. 2003
    ..Thus, the aims of this study were to quantify hepatocyte apoptosis in NASH, correlate it with disease severity, and identify possible mechanisms of apoptosis induction...
  99. pdf Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)
    Stefano Bellentani
    Azienda USL di Modena Liver and Nutrition Centre Ramazzini Hospital Carpi, Modena, Italy
    Ann Hepatol 8:S4-8. 2009
    ..and update the most recent knowledge in the field of prevalence, natural history and incidence of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH)...
  100. ncbi Nonalcoholic fatty liver disease
    Max Bayard
    Department of Family Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee 37604, USA
    Am Fam Physician 73:1961-8. 2006
    Nonalcoholic fatty liver disease is a common condition associated with metabolic syndrome. It is the most common cause of elevated liver enzymes in U.S...
  101. ncbi Histological assessment of non-alcoholic fatty liver disease
    S G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Histopathology 49:450-65. 2006
    Non-alcoholic fatty liver disease (NAFLD) is an important complication of the metabolic syndrome, which is becoming an increasingly common cause of chronic liver disease...

Research Grants102 found, 100 shown here

  1. Biomarkers of Metabolic and Vascular Risk in Obesity
    Vasan Ramachandran; Fiscal Year: 2009
    ..compensation in so-called `healthy obese' include the presence of increased visceral fat, especially fatty liver, higher amounts of intramyocellular fat in skeletal muscle, hepatic and skeletal muscle insulin resistance, and ..
  2. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2007
    ..Both IR and dyslipidemia are pathogenic mechanisms associated with nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) which often present as asymptomatic liver enzyme ..
  3. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2010
    ..invariably followed the formation of microvesicular and macrovesicular lipid droplets indicating nonalcoholic fatty liver disease (NAFLD) and inflammatory changes resembling non-alcoholic steatohepatitis (NASH)...
  4. Biomarkers of Metabolic and Vascular Risk in Obesity
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..compensation in so-called `healthy obese'include the presence of increased visceral fat, especially fatty liver, higher amounts of intramyocellular fat in skeletal muscle, hepatic and skeletal muscle insulin resistance, and ..
  5. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2010
    ..Preliminary data showed that liver DNA is not globally hypermethylated. These -/- mice spontaneously develop fatty liver. Our First Hypothesis is that extra-hepatic tissues from -/- animals with high levels of glycine N- ..
  6. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2009
    ..Preliminary data showed that liver DNA is not globally hypermethylated. These -/- mice spontaneously develop fatty liver. Our First Hypothesis is that extra-hepatic tissues from -/- animals with high levels of glycine N- ..
  7. MECHANISM/S OF ALCOHOL-INDUCED LIVER GRAFT FAILURE
    John Lemasters; Fiscal Year: 2000
    ..grafts is largely brain-dead victims of accidents heavily involving alcohol, the relationship between alcohol, fatty liver, and graft failure following transplantation urgently needs to be understood if the donor pool of usable organs ..
  8. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2010
    ..and validate non-invasive quantitative methods for early diagnosis and quantitative grading of Non-Alcoholic Fatty Liver Disease (NAFLD), using magnetic resonance imaging (MRI)...
  9. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2010
    Chronic alcohol exposure causes the development and maintenance of fatty liver by interfering hepatic fat disposal...
  10. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2009
    Chronic alcohol exposure causes the development and maintenance of fatty liver by interfering hepatic fat disposal...
  11. METABOLICALLY NORMAL AND ABNORMAL OBESITY
    Samuel Klein; Fiscal Year: 2010
    ..effects of weight gain in obese persons who have normal IHTG content compared with those who have nonalcoholic fatty liver disease (NAFLD)...
  12. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..metabolic syndrome have increased hepatic triglycerides (TG) (steatosis) that predisposes them to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) for which there is no consensus treatment...
  13. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..metabolic syndrome have increased hepatic triglycerides (TG) (steatosis) that predisposes them to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) for which there is no consensus treatment...
  14. Genetic Architecture of Adiposity in Multiple Large Cohorts
    Kari E North; Fiscal Year: 2010
    ..obesity is a strong risk factor for numerous other metabolic derangements, diabetes, cardiovascular disease, fatty liver disease, various cancers, as well as a host of other morbidities, there is strong motivation to understand the ..
  15. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2010
    ..in disorders of congenital defects of the urea cycle and of fatty acid oxidation (FAO), nonalcoholic fatty liver disease (NAFLD) and/or "Metabolic Syndrome" (MS)...
  16. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2010
    ..in disorders of congenital defects of the urea cycle and of fatty acid oxidation (FAO), nonalcoholic fatty liver disease (NAFLD) and/or "Metabolic Syndrome" (MS)...
  17. Quantifying Liver Fibrosis with Acoustic Radiation Force
    Kathryn Nightingale; Fiscal Year: 2009
    ..Over 25,000,000 Americans have experienced liver disease. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the western world and is approaching epidemic proportions ..
  18. Quantifying Liver Fibrosis with Acoustic Radiation Force
    Kathryn Radabaugh Nightingale; Fiscal Year: 2010
    ..Over 25,000,000 Americans have experienced liver disease. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the western world and is approaching epidemic proportions ..
  19. Quantifying Liver Fibrosis with Acoustic Radiation Force
    Kathryn Nightingale; Fiscal Year: 2009
    ..Over 25,000,000 Americans have experienced liver disease. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the western world and is approaching epidemic proportions ..
  20. Quantifying Liver Fibrosis with Acoustic Radiation Force
    Kathryn Nightingale; Fiscal Year: 2007
    ..Over 25,000,000 Americans have experienced liver disease. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the western world and is approaching epidemic proportions ..
  21. Adipose Tissue Lipolysis and Alcoholic Fatty Liver
    Zhanxiang Zhou; Fiscal Year: 2009
    Adipose tissue lipolysis and alcoholic fatty liver Project Summary Alcoholic fatty liver is one of the earliest pathological changes in the progression of alcoholic liver disease...
  22. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2010
    ..The specific aims of the proposal are: Aim 1. Investigate the role of miR-122 in a mouse model of nonalcoholic fatty liver disease (NAFLD) related HCC induced by feeding choline-deficient diet...
  23. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2010
    b>Fatty liver disease (FLD) has a variety of causes including chronic alcohol consumption, obesity, viral infection, malnutrition, and acute exposure to hepatotoxins...
  24. Mechanisms of ER stress - induced fatty liver
    D Rutkowski; Fiscal Year: 2009
    b>Fatty liver disease (FLD) has a variety of causes including chronic alcohol consumption, obesity, viral infection, malnutrition, and acute exposure to hepatotoxins...
  25. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2010
    ..an increased risk of developing many secondary conditions, including atherosclerosis, diabetes, non-alcoholic fatty liver disease, periodontal disease, certain cancers, and asthma...
  26. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are rapidly becoming the commonest reason patients in the United States seek advice from a gastroenterologist...
  27. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2007
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are rapidly becoming the commonest reason patients in the United States seek advice from a gastroenterologist...
  28. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2009
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are rapidly becoming the commonest reason patients in the United States seek advice from a gastroenterologist...
  29. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2007
    ..we established that 77% of men and 80% of postmenopausal women, when deprived of dietary choline, developed fatty liver or muscle damage...
  30. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
    ..we established that 77% of men and 80% of postmenopausal women, when deprived of dietary choline, developed fatty liver or muscle damage...
  31. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
    ..we established that 77% of men and 80% of postmenopausal women, when deprived of dietary choline, developed fatty liver or muscle damage...
  32. Homocysteine, ER stress and alcoholic liver injury
    Neil Kaplowitz; Fiscal Year: 2007
    ..the known effect of alcohol on homocysteine metabolism by linking this to the ER stress response and consequent fatty liver, necrosis, and apoptosis which we have observed in the intragastric ethanol fed mouse model...
  33. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2010
    ..been shown to play an essential role in liver dysfunction including necroinflammation, hepatic cell death and fatty liver. We previously observed that alcohol consumption, which is a well-recognized co-factor in susceptibility to the ..
  34. Adipokine Signaling in Macrophages
    Ling Qi; Fiscal Year: 2009
    ..medically important complications, particularly atherosclerosis, cancer, insulin resistance and non-alcoholic fatty liver disease...
  35. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..to develop a rapid, non-invasive and inexpensive diagnostic assay to detect and possibly stage non-alcoholic fatty liver disease (NAFLD)...
  36. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2007
    Obesity is a major risk factor for non-alcoholic fatty liver disease (NAFLD), which represents a spectrum of liver diseases characterized histologically as steatosis, steatohepatitis, fibrosis and cirrhosis...
  37. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2006
    Non-alcoholic steatohepatitis or non-alcoholic fatty liver (NAFL) is a growing clinical problem that may account for a newly recognized etiology for cryptogenic cirrhosis...
  38. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..Non-alcoholic fatty liver disease (NAFLD) may account for the majority of patients who have cryptogenic cirrhosis...
  39. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..Non-alcoholic fatty liver disease (NAFLD) may account for the majority of patients who have cryptogenic cirrhosis...
  40. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2010
    ..Non-alcoholic fatty liver disease (NAFLD) may account for the majority of patients who have cryptogenic cirrhosis...
  41. Ethanol-Induced VDAC Closure in Hepatocytes
    Ekhson Holmuhamedov; Fiscal Year: 2007
    ..glycolysis, glycogen depletion, inhibition of mitochondrial oxidation of medium and long chain fatty acids, and fatty liver changes (steatosis)...
  42. Insulin resistance in the pathogenesis of NASH
    SONIA MICHAEL NAJJAR; Fiscal Year: 2010
    About one third of adults in the United States are diagnosed with fatty liver disease. About 10% will proceed to develop nonalcoholic steatohepatitis (NASH), and associated co-morbidities...
  43. Insulin resistance in the pathogenesis of NASH
    SONIA NAJJAR; Fiscal Year: 2009
    About one third of adults in the United States are diagnosed with fatty liver disease. About 10% will proceed to develop nonalcoholic steatohepatitis (NASH), and associated co-morbidities...
  44. Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea Polyphenols
    Joshua D Lambert; Fiscal Year: 2010
    ..More importantly, dietary EGCG also prevented the development of obesity-related fatty liver disease (ORFLD)...
  45. Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea Polyphenols
    JOSHUA LAMBERT; Fiscal Year: 2009
    ..More importantly, dietary EGCG also prevented the development of obesity-related fatty liver disease (ORFLD)...
  46. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    ELIZABETH SPELIOTES; Fiscal Year: 2007
    ..in obesity has been accompanied by an increase in diabetes, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). NAFLD can result in liver cirrhosis and eventual liver failure...
  47. Tissue specific mechanism of FXR in suppressing bile-acid synthesis
    Grace L Guo; Fiscal Year: 2010
    ..Completion of the proposed study will shed light on designing tissue-specific FXR modulators in the future to better prevent and treat human diseases associated with bile-acid disorders. ..
  48. Tissue specific mechanism of FXR in suppressing bile-acid synthesis
    Grace L Guo; Fiscal Year: 2010
    ..Completion of the proposed study will shed light on designing tissue-specific FXR modulators in the future to better prevent and treat human diseases associated with bile-acid disorders. ..
  49. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2010
    ..S. citizens have steatosis or fat accumulation in their liver cells. The underlying causes of fatty liver (FL) are numerous, but alcohol intake and obesity rank as the most common...
  50. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2009
    ..S. citizens have steatosis or fat accumulation in their liver cells. The underlying causes of fatty liver (FL) are numerous, but alcohol intake and obesity rank as the most common...
  51. Short-Chain Dehydrogenases in Retinol/Sterol Metabolism
    Natalia Kedishvili; Fiscal Year: 2009
    ..signaling through retinoic acid receptors has been implicated in fetal alcohol syndrome, carcinogenesis, fatty liver disease, and diabetes...