alcoholic liver diseases

Summary

Summary: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.

Top Publications

  1. pmc CYP2E1 and oxidative liver injury by alcohol
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 44:723-38. 2008
  2. ncbi Review article: current management of alcoholic liver disease
    S Tome
    Liver Unit, Internal Medicine Department, Complejo Hospitalario Universitario de Santiago de Compostela, Spain
    Aliment Pharmacol Ther 19:707-14. 2004
  3. ncbi Oxidative stress and alcoholic liver disease
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Liver Dis 29:141-54. 2009
  4. ncbi Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
  5. ncbi S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 291:G857-67. 2006
  6. ncbi Iron accumulation in alcoholic liver diseases
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, and Fourth Department of Internal Medicine, Sapporo Medical University, Japan
    Alcohol Clin Exp Res 29:189S-93S. 2005
  7. ncbi Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayer
    R K Rao
    University of Tennessee Health Science Center, Department of Physiology, Memphis, TN, USA
    Methods Mol Biol 447:171-83. 2008
  8. ncbi Role of oxidative stress in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Toxicol 83:519-48. 2009
  9. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
  10. pmc Liver proteome analysis in a rodent model of alcoholic steatosis
    Billy W Newton
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas 77843 3122, USA
    J Proteome Res 8:1663-71. 2009

Detail Information

Publications197 found, 100 shown here

  1. pmc CYP2E1 and oxidative liver injury by alcohol
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 44:723-38. 2008
    ....
  2. ncbi Review article: current management of alcoholic liver disease
    S Tome
    Liver Unit, Internal Medicine Department, Complejo Hospitalario Universitario de Santiago de Compostela, Spain
    Aliment Pharmacol Ther 19:707-14. 2004
    ..Consequently, liver transplantation remains an ultimate option for selected patients with liver failure due to chronic alcoholic liver damage...
  3. ncbi Oxidative stress and alcoholic liver disease
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Liver Dis 29:141-54. 2009
    ..Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury...
  4. ncbi Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
    ..Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes...
  5. ncbi S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 291:G857-67. 2006
    ..These findings reveal new molecular targets through which SAM may work to alleviate one critical component of alcohol-induced liver injury: mitochondria dysfunction...
  6. ncbi Iron accumulation in alcoholic liver diseases
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, and Fourth Department of Internal Medicine, Sapporo Medical University, Japan
    Alcohol Clin Exp Res 29:189S-93S. 2005
    ..In patients with alcoholic liver diseases (ALD), liver iron is increased and the resulted lipid metabolite 4-hydroxynonenal-protein adduct was also ..
  7. ncbi Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayer
    R K Rao
    University of Tennessee Health Science Center, Department of Physiology, Memphis, TN, USA
    Methods Mol Biol 447:171-83. 2008
    ..The mechanisms involved in acetaldehyde-induced increase in intestinal permeability to endotoxins can be elucidated in this model of the intestinal epithelium...
  8. ncbi Role of oxidative stress in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Toxicol 83:519-48. 2009
    ..Special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS...
  9. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...
  10. pmc Liver proteome analysis in a rodent model of alcoholic steatosis
    Billy W Newton
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas 77843 3122, USA
    J Proteome Res 8:1663-71. 2009
    ..In addition, the carbonylation of betaine-homocysteine S-methyltransferase, a protein implicated in fatty liver development, in 3-week and 6-week ethanol exposed samples suggests that this protein could be a marker for early stage AS...
  11. ncbi Nf-kappab activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease
    K Jokelainen
    Department of Pathology, Harvard Medical School, Boston, MA, USA
    Cytokine 16:36-9. 2001
    ..Thus, activation of NF-kappaB, associated with elevated mRNA levels of pro-inflammatory stimuli, precedes the histopathological liver changes in experimental alcoholic liver disease in rats...
  12. ncbi Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
    E K Kuffner
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2247-52. 2001
    ..Millions of patients use acetaminophen; the prevalence of alcoholism in the United States is 5% to 10%...
  13. ncbi CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, New York, NY 10029, USA
    Mt Sinai J Med 73:657-72. 2006
    ..Regulation of CYP2E1 is quite complex and will be briefly reviewed. Future directions in research, which may help clarify the actions of CYP2E1 and its role in alcoholic liver injury, are suggested...
  14. ncbi Role of microsomal enzymes in development of alcoholic liver diseases
    Masahiro Konishi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 22:S7-10. 2007
    ..This review article briefly describes a role of microsomal enzymes in the development of alcoholic liver injury as well as the usefulness of this cell line to further clarify the mechanisms of CYP2E1-related hepatotoxicity...
  15. ncbi Current status of liver diseases in Korea: toxic and alcoholic liver diseases
    Kyung Ah Kim
    Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
    Korean J Hepatol 15:S29-33. 2009
    ..Several studies have shown that alcohol increased the risk of HCC in liver cirrhosis with HBsAg or anti-HCV. Furthermore, alcoholic cirrhosis with occult hepatitis B virus infection increased the risk of HCC...
  16. ncbi Alcohol in hepatocellular cancer
    Michael D Voigt
    4553E JCP, 200 Hawkins Drive, Iowa City, IA 52245, USA
    Clin Liver Dis 9:151-69. 2005
    ..This review summarizes the epidemiologic evidence for the role of alcohol in hepatocellular cancer, and discusses the mechanisms involved in the promotion of cancer...
  17. ncbi Recent advances in alcohol-induced adduct formation
    Thomas L Freeman
    University of Nebraska Medical Center and the Veterans Administration Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 29:1310-6. 2005
  18. ncbi S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet
    Jesus A Villanueva
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1934-43. 2007
    ....
  19. ncbi Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation
    Sun J Kim
    College of Pharmacy, Seoul National University, San 56 1 Shinrim Dong, Kwanak Ku, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 368:893-8. 2008
    ..The results suggest that betaine may protect the liver against ethanol-induced oxidative injury most probably via its effects on the sulfur-amino acid metabolism...
  20. ncbi Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver Disease
    Jaana Latvala
    Department of Laboratory Medicine and Addiction Research Unit, EP Central Hospital, Seinajoki, and University of Tampere, Finland
    Am J Gastroenterol 100:1303-10. 2005
    ..Excessive alcohol consumption is associated with the generation of antibodies against neoantigens induced by ethanol metabolism. However, the associations between such immune responses, ethanol consumption, and liver injury remain unclear...
  21. ncbi Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury
    O Niemela
    EP Central Hospital Laboratory, Seinajoki, Finland
    Free Radic Biol Med 31:1533-8. 2001
    ..Elevated adduct levels also occur in erythrocytes of alcoholics, which may be related to ethanol-induced morphological aberrations in hematopoiesis...
  22. ncbi Psychiatric differences between liver transplant candidates with familial amyloid polyneuropathy and those with alcoholic liver disease
    Diogo Telles-Correia
    University of Lisbon, Lisbon, Portugal
    Prog Transplant 18:134-9. 2008
    ..Also, nonadherence before the transplant is predictive of nonadherence after the transplant...
  23. pmc Hepatitis C virus and alcohol
    Larry Siu
    Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Semin Liver Dis 29:188-99. 2009
    ..Clinical studies are needed to optimize treatment responses in alcoholic patients with chronic HCV infection...
  24. ncbi Increased serum levels of macrophage migration inhibitory factor in alcoholic liver diseases and their expression in liver tissues
    T Kumagi
    Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan
    Clin Biochem 34:189-93. 2001
    OBJECTIVES: To study the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of alcoholic liver diseases. DESIGN AND METHODS: The levels of MIF in the sera were estimated by an enzyme-linked immunosorbent assay in 13 ..
  25. ncbi Hepatic encephalopathy--a serious complication of alcoholic liver disease
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Canada
    Alcohol Res Health 27:143-5. 2003
    ....
  26. ncbi Alcohol induced hepatic fibrosis: role of acetaldehyde
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Mol Aspects Med 29:17-21. 2008
    ..S., 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257, 59-84]. This review will focus on the molecular mechanisms by which acetaldehyde promote liver fibrosis...
  27. ncbi The chemistry and biological effects of malondialdehyde-acetaldehyde adducts
    G M Thiele
    Departments of Internal Medicine, Pathology Microbiology, University of Nebraska Medical Center, and the Omaha VA Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 25:218S-224S. 2001
    ..Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduct and its significance in alcoholic liver injury and ALDH2 heterozygotes, by Naruhiko Nagata...
  28. ncbi The epidemiology of alcoholic liver disease
    Robert E Mann
    Department of Social, Prevention and Health Policy Research at the Centre for Addiction and Mental Health, Toronto, Canada
    Alcohol Res Health 27:209-19. 2003
    ....
  29. ncbi Dysregulation of systemic iron metabolism in alcoholic liver diseases
    Yutaka Kohgo
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Gastroenterol Hepatol 23:S78-81. 2008
    b>Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently, the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been clarified in detail...
  30. ncbi [Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats]
    Wu pi Jin
    Affiliated Hospital of Yanbian University, Yanji 133000, Jilin, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19:419-21. 2007
    ..To observe the pathological changes and investigate the correlation of hepatocyte apoptosis with cytochrome P450 2E1(CYP2E1) expression and oxygen free radical in alcoholic liver disease (ALD) in rat...
  31. ncbi Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption
    Geoffrey M Thiele
    Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, OH, USA
    Methods Mol Biol 447:235-57. 2008
    ..In this chapter, methods for the production and detection of these modified proteins will be discussed...
  32. ncbi Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseases
    Fuminori Hirano
    Second Department of Internal Medicine, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa, 078 8510, Japan
    J Hepatol 38:483-9. 2003
    ..concentration of plasma tumor necrosis factor alpha (TNF-alpha) correlates with the clinical course of alcoholic liver diseases. In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with ..
  33. ncbi Free radical mechanisms in immune reactions associated with alcoholic liver disease
    Emanuele Albano
    Department of Medical Sciences, University Amedeo Avogadro of East Piedmont, Novara, Italy
    Free Radic Biol Med 32:110-4. 2002
    ..Altogether, these observations suggest the importance of ethanol-induced oxidative stress in stimulating immune reactions towards both liver allo-and self-antigens...
  34. ncbi Malondialdehyde-acetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells
    K K Kharbanda
    VA Alcohol Research Center, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Alcohol 25:123-8. 2001
    ..These findings indicate that MAA-adducted proteins may play a role in the modulation of the hepatic inflammatory response and could contribute to the pathogenesis of alcoholic liver disease...
  35. pmc Developments in liver transplantation
    J Neuberger
    The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    Gut 53:759-68. 2004
  36. ncbi "Hypothesis of seven balances": molecular mechanisms behind alcoholic liver diseases and association with PPARalpha
    Takashi Moriya
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Aichi, Japan
    J Occup Health 51:391-403. 2009
    The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated ..
  37. ncbi Methionine synthase. a possible prime site of the ethanolic lesion in liver
    Anthony J Barak
    Liver Study Unit and V A Alcohol Research Center, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Alcohol 26:65-7. 2002
    ....
  38. ncbi De Ritis ratio as diagnostic marker of alcoholic liver disease
    Shankhar Majhi
    Department of Clinical Laboratory Services Biochemistry Unit, B P Koirala Institute of Health Sciences, Ghopa Dharan Nepal
    Nepal Med Coll J 8:40-2. 2006
    Patients suffering from Alcoholic Liver Diseases (ALD) are often diagnosed by spectrum of physical manifestations and laboratories abnormalities...
  39. pmc Treatment of alcoholic liver disease
    Ina Bergheim
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Dig Dis 23:275-84. 2005
    ..Treatment of the complications of ALD can improve the quality of life and, in some cases, decrease short-term mortality...
  40. ncbi Alcohol: who is at risk?
    Nick Sheron
    Southampton General Hospital and University of Southampton Medical School
    Practitioner 249:694, 696, 698-701. 2005
  41. ncbi Severe alcohol-induced liver disease and the alcohol dependence syndrome
    Stewart Smith
    Liver Unit, University of Southampton Medical School and Southampton University Hospitals Trust, UK
    Alcohol Alcohol 41:274-7. 2006
    ....
  42. ncbi Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 134:904-12. 2004
    ..These findings may be important in the nutritional management and treatment of alcoholic liver disease...
  43. ncbi Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury
    Laura E Nagy
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 4906, USA
    Annu Rev Nutr 24:55-78. 2004
    ....
  44. ncbi Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
    Tamie Nakajima
    Department of Hygiene and Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 40:972-80. 2004
    ..Humans may be more susceptible to liver toxicity induced by ethanol as PPARalpha expression in human liver is considerably lower compared to that of rodents...
  45. ncbi The effect of rotenone on the urinary ethanol cycle in rats fed ethanol intragastrically
    J Li
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Exp Mol Pathol 77:210-3. 2004
    ..When this fluctuation is blocked by rotenone, the cycle does not occur. It is concluded that the urinary ethanol cycle is dependent on cyclic fluctuation of the NAD/NADH ratio, which regulates the rate of ethanol elimination...
  46. ncbi The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury
    Pornpen Pramyothin
    Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Ethnopharmacol 107:361-4. 2006
    ..o.) enhanced liver cell recovery by bringing the levels of AST, ALT, IL-1beta back to normal. Histopathological studies confirmed the beneficial roles of PE and SL against ethanol induced liver injury in rats...
  47. ncbi Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats
    Terrence M Donohue
    Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1944-52. 2007
    ..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid...
  48. ncbi Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats
    Jeong Sook Lee
    Department of Food and Nutrition, Kosin University, Busan 606 701, South Korea
    Clin Chim Acta 347:121-8. 2004
    ..Water extract of Pueraria radix (PRWE), traditional oriental medicinal plant, may have an effect on the activity of hepatic antioxidant enzymes and lipid profile in ethanol-treated rats...
  49. ncbi Relationships between nutrition, alcohol use, and liver disease
    Charles S Lieber
    Mount Sinai School of Medicine, Bronx, New York, USA
    Alcohol Res Health 27:220-31. 2003
    ..New agents currently are being studied as promising nutritional supplements for alcoholics with liver disease...
  50. ncbi [Protective effects of bicyclol on alcohol-induced liver damage in mice]
    Cheng lin Mo
    Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    Zhonghua Yi Xue Za Zhi 85:3409-13. 2005
    ..To study the protective effect of bicyclol on alcohol-induced liver injury in mice...
  51. ncbi Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:5128-36. 2006
    ..The accumulation of CYP2E1 in hepatic mitochondria induced by ethanol consumption might play an important role in alcohol liver disease...
  52. ncbi Oxidative stress and signal transduction pathways in alcoholic liver disease
    Tomas Zima
    Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:110S-115S. 2005
    ..We are only at the beginning .....
  53. ncbi Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicity
    Vairappan Balasubramaniyan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India
    J Pharm Pharmacol 58:1113-9. 2006
    ..These findings were consistent with our histological observations, confirming that leptin enhanced liver ailments in ethanol-supplemented mice...
  54. ncbi Cytologic alterations in the oral mucosa after chronic exposure to ethanol
    Silvia Regina de Almeida Reis
    Department of Propaedeutics and Integrated Clinic, School of Dentistry, Federal University of Bahia
    Braz Oral Res 20:97-102. 2006
    ..05; Spearman). In conclusion, chronic exposure to ethanol may be associated with carcinogenic cytologic changes in the oral mucosa, even in the absence of tobacco smoking. These alterations were not correlated with hepatobiliary injury...
  55. pmc Epigenetic effects of ethanol on liver and gastrointestinal injury
    Shivendra D Shukla
    World J Gastroenterol 12:5265-71. 2006
    ..Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential...
  56. ncbi Signal transduction in alcohol-related diseases
    Minoti V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Alcohol Clin Exp Res 29:1299-1309. 2005
  57. ncbi Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats
    Seda Yalçinkaya
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    Exp Toxicol Pathol 58:455-9. 2007
    ..Our results show that HM diet may augment hepatotoxicity and oxidative stress in the liver of chronically ethanol-treated rats...
  58. pmc Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    Zhanxiang Zhou
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
    Am J Pathol 166:1681-90. 2005
    ..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways...
  59. ncbi Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition
    January N Baumgardner
    Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 293:G355-64. 2007
    ..However, enhanced ethanol-induced cellular proliferation, perhaps as a result of enhanced PPAR-alpha signaling, may contribute to an increased risk of hepatocellular carcinoma in undernourished alcoholics...
  60. ncbi Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 289:G54-63. 2005
    ....
  61. ncbi Modulation of lecithin activity by vitamin-B complex to treat long term consumption of ethanol induced oxidative stress in liver
    Subir Kumar Das
    Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P O Cochin 682 026, India
    Indian J Exp Biol 44:791-801. 2006
    ..Furthermore, preventive measures were more effective than curative treatment. Prevention of oxidative and nitrosative stress along with correction of nutritional deficiency is one of the proposed mechanisms for the therapeutic approach...
  62. ncbi Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver disease
    Udayan M Apte
    Department of Pathobiology, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Toxicol Pathol 32:567-76. 2004
    ..These data suggest the transient decline in liver injury during alcoholic steatosis is due to enhanced NF-kappaB-dependent hepatocyte proliferation...
  63. ncbi Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration
    Anna Mae Diehl
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1-6. 2005
    ..Delineation of these mechanisms and clarification of how ethanol influences them might suggest new therapies for alcoholic liver disease...
  64. ncbi Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver
    Igor Bykov
    National Public Health Institute, Departments of Mental Health and Alcohol Research, POB 33, 00250 Helsinki, Finland
    Clin Immunol 124:213-20. 2007
    ..Lipocalin-2 and SPARC emerge as new candidate markers for early detection of liver damage...
  65. ncbi Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential
    Zili Dan
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 19:845-7. 2005
    ..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
  66. ncbi Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets
    Martin J J Ronis
    Department of Pharmacology and Toxicology, UAMS, Arkansas Children s Nutrition Center, Little Rock Arkansas, 72205, USA
    Exp Biol Med (Maywood) 229:351-60. 2004
    ....
  67. ncbi Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    M Yin
    Laboratory of Hepatobiology, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Gastroenterology 117:942-52. 1999
    ..To obtain clear evidence for or against the hypothesis that TNF-alpha is involved, we studied TNF receptor 1 (TNF-R1, p55) or 2 (TNF-R2, p75) knockout mice...
  68. ncbi Alcohol use and HIV pharmacotherapy
    Thomas F Kresina
    National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    AIDS Res Hum Retroviruses 18:757-70. 2002
    ....
  69. ncbi The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats
    Fawzia Bardag-Gorce
    Department of Pathology, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Gastroenterology 123:325-35. 2002
    ..The question is how the liver differs at the peaks and troughs of the UAL cycle. Hypoxic injury is postulated to occur at the peaks. Therefore, liver injury may be different at the peaks and troughs...
  70. ncbi Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage
    Kengathevy Morgan
    VA Medical Center, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Hepatology 36:122-34. 2002
    ..In conclusion, we have produced a transgenic mouse that expresses human CYP2E1 in the liver. When fed a nutritionally complete alcohol diet, transgenic mice develop more liver damage than nontransgenic mice...
  71. ncbi The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
    ..However, the induction of IRF7, an IRF3-inducible gene, was found in Kupffer cells of alcohol-fed WT mice. Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner...
  72. ncbi Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress
    Zhanxiang Zhou
    Departments of Medicine, Pharmacology, and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202 Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202
    Exp Biol Med (Maywood) 227:214-22. 2002
    ..In conclusion, MT is an effective agent in cytoprotection against alcohol-induced liver injury, and hepatic protection by MT is likely through inhibition of alcohol-induced oxidative stress...
  73. ncbi Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins
    Feng Hong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:32-43. 2002
    ..These findings suggest that elevated serum IL-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6-mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis by induction of Bcl-2 and Bcl-x(L)...
  74. ncbi Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1
    M K Aleynik
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    Biochem Biophys Res Commun 288:1047-51. 2001
    ..DLPC decreases ethanol-induced CYP2E1 and should be considered for the prevention of alcoholic liver disease...
  75. ncbi RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1744-8. 2005
    ....
  76. ncbi The antiestrogen toremifene protects against alcoholic liver injury in female rats
    H A Järveläinen
    National Public Health Institute, Alcohol Research Center, Helsinki, Finland
    J Hepatol 35:46-52. 2001
    ..Females are generally considered to be more susceptible to alcohol-induced liver injury than males. To elucidate whether gonadal hormones are involved, female rats were chronically treated with ethanol and with an antiestrogen...
  77. ncbi Ethanol and oxidative stress
    A Y Sun
    Department of Pharmacology (AYS, GYS, University of Missouri, Columbia, Missouri 65212, USA
    Alcohol Clin Exp Res 25:237S-243S. 2001
    ..Sun and Grace Y. Sun...
  78. ncbi ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice
    H Kono
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1289-95. 2001
    ..These data demonstrate that ICAM-1 and infiltrating leukocytes play important roles in early alcohol-induced liver injury, most likely by mechanisms involving TNF-alpha...
  79. ncbi Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol
    S Fleming
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Alcohol Clin Exp Res 25:579-89. 2001
    ..Collectively, these studies suggest that both pro- and anti-inflammatory soluble mediators in the intestine maintain and exacerbate the local hepatic response to ethanol...
  80. pmc An in vitro method of alcoholic liver injury using precision-cut liver slices from rats
    Lynell W Klassen
    Experimental Immunology Laboratory, University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology, 983025 Nebraska Medical Center, Omaha, NE 68198 3025, USA
    Biochem Pharmacol 76:426-36. 2008
    ..Therefore, this model system appears to mimic the ethanol-induced changes in the liver that have been previously reported in human and animal studies, and may be a useful model for the study of alcoholic liver disease...
  81. ncbi The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae)
    Shih Chang Lee
    Department of Food Science, National Chung Hsing University, Taichung, Taiwan, ROC
    Am J Chin Med 30:609-16. 2002
    ....
  82. ncbi [Alcohol-induced gastrointestinal diseases]
    Ferenc Szalay
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 144:1659-66. 2003
    ..Metabolites, mainly acetaldehyde and free radicals are responsible for the injury. Although the alcohol itself is not carcinogenic, some maligancies are more common among alcoholics...
  83. ncbi [Influence of ethanol on oxidative stress in the liver]
    Elzbieta Skrzydlewska
    Zakład Chemii Nieorganicznej i Analitycznej, Akademia Medyczna w Białymstok
    Przegl Lek 59:848-53. 2002
    ..It intensifies free radical action on cell compartments which are characterized by oxidative modification of lipids, proteins and nucleic acids. These cytotoxic processes may finally lead to alcoholic liver injury in the end...
  84. ncbi Hemochromatosis and alcoholic liver disease
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Alcohol 30:131-6. 2003
    ..In addition, the cumulative effects of other forms of liver injury may result when iron and alcohol are present concurrently. Clearly, the addition of dietary iron in subjects homozygous for hemochromatosis would be unwise...
  85. ncbi Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?
    Tracey A Rouault
    Section on Human Iron Metabolism, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
    Alcohol 30:103-6. 2003
    ..However, it is not known why hepatic iron accumulation occurs or how it contributes to disease progression. In this review, information about the role of iron in the pathophysiology of liver disease is reviewed and discussed...
  86. ncbi [Alcoholic liver disease]
    Marek Waluga
    Katedry i Kliniki Gastroenterologii Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 56:61-70. 2003
    ..Apart from abstinence, the treatment of alcohol liver disease is based on hyperalimentation, since alcoholism is generally associated with protein malnutrition. In severe forms of alcohol hepatitis corticosteroids are recommended...
  87. ncbi Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease
    Samir Zakhari
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Hepatology 46:2032-9. 2007
    ....
  88. ncbi A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction
    Shannon M Bailey
    Department of Environmental Health Sciences and Center for Free Radical Biology, School of Public Health, The University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
    Free Radic Res 37:585-96. 2003
    ....
  89. ncbi Protective and alleviative effects from 4 cysteine-containing compounds on ethanol-induced acute liver injury through suppression of oxidation and inflammation
    Sheng Lei Yan
    Div of Gastroenterology, Dept of Internal Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
    J Food Sci 72:S511-5. 2007
    ..05). These results support that SEC and SPC could provide both preventive and alleviative effects against alcohol-induced hepatotoxicity through suppression of oxidation and inflammation...
  90. ncbi A voluntary oral-feeding rat model for pathological alcoholic liver injury
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
    Methods Mol Biol 447:11-31. 2008
    ....
  91. ncbi Isolation of Kupffer cells from rats fed chronic ethanol
    Megan R McMullen
    Department Pathobiology, Cleveland Clinic, Cleveland, OH, USA
    Methods Mol Biol 447:199-212. 2008
    ..The isolation and culture of Kupffer cells is an important technique with which one can elucidate the mechanisms that contribute to alcoholic liver injury...
  92. ncbi Role of leptin on alcohol-induced oxidative stress in Swiss mice
    V Balasubramaniyan
    Department of Biochemistry, Annamalai University, Annamalainagar 608002, Tamilnadu, India
    Pharmacol Res 47:211-6. 2003
    ..It is postulated that the increase in systemic leptin levels enhance the oxidative stress, and lower the antioxidant defence, leading to augmented hepatic inflammation in alcoholic liver disease...
  93. ncbi Infiltrating polymorphonuclear leukocytes and apoptotic bodies derived from hepatocytes but not from ballooning hepatocytes containing Mallory bodies show nuclear DNA fragmentation in alcoholic hepatitis
    T Takahashi
    Third Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
    Alcohol Clin Exp Res 24:68S-73S. 2000
    ..The mechanism of liver cell death in alcoholic hepatitis is still controversial. There is evidence that polymorphonuclear leukocytes (PMNs) which infiltrate liver parenchyma are involved in liver cell death...
  94. ncbi Serum intercellular adhesion molecule-1 in patients with nonalcoholic steatohepatitis: comparison with alcoholic hepatitis
    Shuji Ito
    Department of Internal Medicine, Atsugi Municipal Hospital, Kanagawaken, Japan
    Alcohol Clin Exp Res 31:S83-7. 2007
    ..In this study, we clarified the significance of serum ICAM-1 levels in patients with NAFLD, and especially in NASH...
  95. ncbi Scanning electron microscopic studies on morphological abnormalities of erythrocytes in alcoholic liver diseases
    S Takashimizu
    Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Alcohol Clin Exp Res 24:81S-86S. 2000
    ..We previously reported that morphological abnormalities and the altered deformability of erythrocytes play important roles in disturbances of hepatic microcirculation associated with alcoholic liver disease...
  96. ncbi Serum ubiquitin-protein conjugates in normal subjects and patients with alcoholic liver diseases: immunoaffinity isolation and electrophoretic mobility
    Masaru Takagi
    Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Alcohol Clin Exp Res 26:1692-6. 2002
    ....
  97. ncbi Platelet activation in patients with alcoholic liver disease
    Fusao Ogasawara
    Department of Internal Medicine, Tokai University School of Medicine, Hachioji Hospital, 1838 Ishikawa machi, Hachioji, Tokyo 192 0032, Japan
    Tokai J Exp Clin Med 30:41-8. 2005
    To elucidate the mechanisms of thrombocytopenia in alcoholic liver diseases, we investigated activation status of platelets in patients with alcoholic fatty liver (Al-FL), alcoholic liver cirrhosis (Al-LC) or hepatitis-C liver cirrhosis C ..
  98. pmc Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control study
    Henning Grønbaek
    Department of Medicine V, Aarhus University Hospital, Denmark
    BMC Gastroenterol 8:16. 2008
    ..Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases...
  99. ncbi A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies
    Kiyoko Hirano
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Histochem Cell Biol 132:293-304. 2009
    ..keratin-rich inclusion bodies observed in human alcoholic liver disease and in several chronic non-alcoholic liver diseases. The mechanism of their formation and their relationship to other inclusion bodies such as aggresomes is ..
  100. ncbi [Effect of tea polyphenols on expression of nuclear factor kappa B]
    Yuan ting Tang
    Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China
    Zhonghua Gan Zang Bing Za Zhi 17:301-5. 2009
    To investigate the effect of tea polyphenols (TP) on expression of nuclear factor kappa B (NF-kB) in rats with alcoholic liver diseases and in cells treated with alcohol.
  101. ncbi The interleukin-17 pathway is involved in human alcoholic liver disease
    Arnaud Lemmers
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Hepatology 49:646-57. 2009
    Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding alcoholic hepatitis inflammatory burst. Interleukin-17 (IL-17) is known to enhance neutrophil recruitment...

Research Grants62

  1. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary Alcoholic liver diseases (ALD) -- ranging from alcoholic fatty liver to alcohol-induced liver fibrosis and cirrhosis - - account for more than 50% of all chronic liver diseases in ..
  2. Role of sumoylation in alcoholic liver disease
    Maria Lauda Tomasi; Fiscal Year: 2013
    ..The liver, as the primary site of alcohol metabolism, is a major target of injury. The spectrum of Alcoholic Liver Diseases (ALD) includes simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma...
  3. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    ..This study, if successful, may delineate key signaling pathways in alcoholic liver disease and identify new targets for preventing and treating alcoholic liver diseases as well as other forms of liver diseases.
  4. The Role of Autophagy in Alcohol-Induced Liver Injury
    Wen Xing Ding; Fiscal Year: 2010
    ..However, the pathogenesis of alcoholic liver diseases (ALD) is not completely understood although recent researches suggest that oxidative stress- induced ..
  5. Mechanisms regulating autophagy in alcohol-induced liver injury
    Wen Xing Ding; Fiscal Year: 2013
    ..Therefore modulating the autophagy process could offer new therapeutic treatments for alcoholic liver diseases. However, the mechanisms by which ethanol induces autophagy and how autophagy protects against ethanol-..
  6. Alcoholic Liver Diseases: Damage, Repair and Stem Cell Regeneration
    Zhaoli Sun; Fiscal Year: 2013
    ..Zhaoli Sun's expertise in liver transplantation models and Dr. Bin Gao's expertise in alcoholic liver diseases so that, as a functioning collaborative unit, innovative new therapies based on examinations of extra-..
  7. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2012
    ..acute and chronic alcohol responses in human monocytes represents a unique and clinically applicable approach to better understand human conditions modified by alcohol intake including coronary heart disease and alcoholic liver diseases.
  8. PATHOGENESIS & TREATMENT OF ALCOHOL-INDUCED DISEASES
    Charles Lieber; Fiscal Year: 1980
    ..The role of protein retention and immunological reactions in the development of alcoholic liver diseases will be determined...
  9. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  11. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  12. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  13. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  14. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  15. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2010
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  16. Planning Grant for Louisville Clinical and Translational Science Award
    Craig McClain; Fiscal Year: 2006
    ..Expand and integrate a clinical and translational research resources and outreach network. [unreadable] [unreadable] [unreadable]..
  17. Mechanisms of S-adenosylmethionine in NASH
    Craig McClain; Fiscal Year: 2009
    ..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
  18. A.S.P.E.N. Research Workshop on Functional Foods
    Craig McClain; Fiscal Year: 2002
    ..abstract_text> ..
  19. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..abstract_text> ..
  20. Long-term Outcome: Transplant for Alcohol Liver Disease
    Andrea F DiMartini; Fiscal Year: 2010
    ..We also expect to use these data to develop treatment intervention studies for the future. ..
  21. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
  22. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  23. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  24. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. [unreadable] [unreadable]..
  25. TNF Alpha and Recovery from Alchoholic Liver Injury
    Anna Mae Diehl; Fiscal Year: 2009
    ..This, in turn, might identify novel genetic susceptibility factors for alcohol-related cirrhosis, new biomarkers for ALD progression, and novel therapeutic targets for this common liver disease. ..
  26. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  27. Redox Modification of Thiols in Alcohol Hepatotoxicity
    Shannon Bailey; Fiscal Year: 2008
    ..New information on the molecular targets of SAM will also be achieved, which will enable the design of effective therapeutic strategies to treat liver diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    ..The results would have high potential leading to a simplistic approach to prevention/treatment of ALD. ..
  29. Chronic Alcohol and Liver Oxidative Stress
    Shannon Bailey; Fiscal Year: 2003
    ..This investigation should thus provide information on ethanol-elicited alterations that contribute to oxidative damage in the liver. ..
  30. Proteomics of Oxidant-Induced Mitochondrial Damage in an Animal Model of NASH
    Shannon Bailey; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  31. REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS
    Shelly Lu; Fiscal Year: 2008
    ..Our ultimate goal is to utilize this information to improve the treatment and prevent complications that may result from altered hepatic GSH synthesis. [unreadable] [unreadable]..
  32. Effects of Ethanol on Endocytosis in the Liver
    CAROL CASEY; Fiscal Year: 2009
    ..This increased fibronectin concentration contributes to the pathogenesis of liver injury by its role in the initiation of the fibrogenic cascade ..
  33. THE ROLE OF IMMUNE RESPONSES IN ALCOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2007
    ..4. To define the role of NK cells in the hepatitis associated with MCMV infection of alcohol-fed mice. ..
  34. MAT1A NULL MOUSE: MODEL FOR ALCOHOLIC TISSUE INJURY
    Shelly Lu; Fiscal Year: 2007
    ....
  35. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  36. BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2004
    ..The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver. ..
  37. Mechanisms of Alcohol Mediated Organ and Tissue Damage
    Gyongyi Szabo; Fiscal Year: 2005
    ..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
  38. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ....
  39. A ROLE FOR VIRAL INFECTION IN ALCOHOLIC PANCREATITIS
    THOMAS JERRELLS; Fiscal Year: 2005
    ..The model system will also allow critical studies of possible therapeutic interventions. ..
  40. BIOENERGETICS AND ALCOHOLIC LIVER DISEASE PATHOGENESIS
    Anna Mae Diehl; Fiscal Year: 2004
    ..g., TNFalpha) that promote EtOH-hepatotoxicity; and 3) to determine if increased ROS production induces UCP2 and, thus, if inhibiting ROS by antioxidant therapy will prevent UCP2 induction, mitochondrial dysfunction, and liver damage. ..
  41. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  42. Modulation by SAMe of CYP2E1-dependent Effects in Liver.
    Arthur Cederbaum; Fiscal Year: 2006
    ....
  43. CYCLOOXYGENASE-2 AND ALCOHOLIC LIVER DISEASE
    Amin Nanji; Fiscal Year: 2003
    ..The prevention and treatment of alcoholic liver injury by Cox-2 inhibitors in these experiments should provide data for the testing of these drugs in patients with alcoholic liver disease. ..
  44. MECHANISM OF ETHANOL INDUCED IMPAIRMENTS IN IMMUNITY
    THOMAS JERRELLS; Fiscal Year: 2002
    ..By using the various infectious model systems in place in this laboratory the ETOH-mediated effects on the subsets of helper T cells (TH-1 and TH-2) will also be defined. ..
  45. Epidemiology and Impact of Hepatitis C in the Community
    W Ray Kim; Fiscal Year: 2007
    ..abstract_text> ..
  46. Degradation of Human CYP2E1 by the Proteasome
    Arthur Cederbaum; Fiscal Year: 2004
    ..Modulators of any of these newly identified steps may have therapeutic implications for individuals with high levels of CYP2E1. ..
  47. ALCOHOL OXYGEN RADICAL INTERACTIONS AS DETECTED BY ESR
    Arthur Cederbaum; Fiscal Year: 2001
    ..These studies will provide new information on the ability of NO to modulate CYP2El catalytic activity, generation of reactive intermediates, and ethanol and PUFA toxicity. ..
  48. ALCOHOL AND PYRAZOLE REACTION AND METABOLISM BY CYP2E1
    Arthur Cederbaum; Fiscal Year: 2006
    ..It is hoped that such studies in hepatocyte and HepG2 cell culture models and in-vivo models, will help to define further the biochemical and toxicological actions of CYP2E1 and its role in alcohol-induced liver injury. ..
  49. Effects of ethanol and CYP2E1 on liver function
    Arthur Cederbaum; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  50. Zinc and Alcohol-Induced Oxidative Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2009
    ..These studies will provide fundamental understanding of the role of zinc in the pathophysiology of ALD, and pave the way to novel therapeutical approaches to prevention and treatment of this disease. ..
  51. Metallothionein in Chronic Alcoholic Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2004
    ..These studies will provide fundamental understanding of the role and possible clinical application of MT in cytoprotection against chronic alcohol-induced liver injury, a major clinical health problem without FDA approved therapy. ..
  52. Ethanol Effects on Antigen Presentation in Liver Cells
    Natalia Osna; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. BIOIRON RESEARCH CONFERENCES 2001-2005
    Gary Brittenham; Fiscal Year: 2003
    ..The overall goal of the Bioiron World Congress is the international dissemination of important new research results to investigators working in the field of iron metabolism. ..
  54. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  55. Alcoholic Hepatitis: Molecular Mechanisms
    Stephen Safe; Fiscal Year: 2008
    ..The long-term goal of this project is to device appropriate therapies that will prevent neutrophilic steatohepatitis in chronic alcoholics by reducing neutrophil infiltration into liver. [unreadable] [unreadable] [unreadable]..
  56. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  57. Oxidative Stress and Heart Failure by Copper Restriction
    Y James Kang; Fiscal Year: 2010
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  58. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2009
    ..Significance: Showing that ALD requires a leaky gut, &that NO &cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test);2) lead to therapies to prevent LD in those drinkers unable to abstain. ..