Genomes and Genes
alcoholic liver diseases
Summary: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
Publications177 found, 100 shown here
- CYP2E1 and oxidative liver injury by alcoholYongke Lu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 44:723-38. 2008....
- Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposiumVishnudutt Purohit
Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
Alcohol 42:349-61. 2008..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...
- Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayerR K Rao
University of Tennessee Health Science Center, Department of Physiology, Memphis, TN, USA
Methods Mol Biol 447:171-83. 2008..The mechanisms involved in acetaldehyde-induced increase in intestinal permeability to endotoxins can be elucidated in this model of the intestinal epithelium...
- S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liverShannon M Bailey
Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
Am J Physiol Gastrointest Liver Physiol 291:G857-67. 2006..These findings reveal new molecular targets through which SAM may work to alleviate one critical component of alcohol-induced liver injury: mitochondria dysfunction...
- Liver proteome analysis in a rodent model of alcoholic steatosisBilly W Newton
Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas 77843 3122, USA
J Proteome Res 8:1663-71. 2009..In addition, the carbonylation of betaine-homocysteine S-methyltransferase, a protein implicated in fatty liver development, in 3-week and 6-week ethanol exposed samples suggests that this protein could be a marker for early stage AS...
- Oxidative stress and alcoholic liver diseaseDefeng Wu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
Semin Liver Dis 29:141-54. 2009..Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury...
- Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genesAmin A Nanji
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003..Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes...
- Role of oxidative stress in alcohol-induced liver injuryArthur I Cederbaum
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
Arch Toxicol 83:519-48. 2009..Special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS...
- Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trialE K Kuffner
Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
Arch Intern Med 161:2247-52. 2001..Millions of patients use acetaminophen; the prevalence of alcoholism in the United States is 5% to 10%...
- CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injuryArthur I Cederbaum
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, New York, NY 10029, USA
Mt Sinai J Med 73:657-72. 2006..Regulation of CYP2E1 is quite complex and will be briefly reviewed. Future directions in research, which may help clarify the actions of CYP2E1 and its role in alcoholic liver injury, are suggested...
- Role of microsomal enzymes in development of alcoholic liver diseasesMasahiro Konishi
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
J Gastroenterol Hepatol 22:S7-10. 2007..This review article briefly describes a role of microsomal enzymes in the development of alcoholic liver injury as well as the usefulness of this cell line to further clarify the mechanisms of CYP2E1-related hepatotoxicity...
- "Hypothesis of seven balances": molecular mechanisms behind alcoholic liver diseases and association with PPARalphaTakashi Moriya
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Aichi, Japan
J Occup Health 51:391-403. 2009The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated ..
- Current status of liver diseases in Korea: toxic and alcoholic liver diseasesKyung Ah Kim
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
Korean J Hepatol 15:S29-33. 2009..Several studies have shown that alcohol increased the risk of HCC in liver cirrhosis with HBsAg or anti-HCV. Furthermore, alcoholic cirrhosis with occult hepatitis B virus infection increased the risk of HCC...
- [Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats]Wu pi Jin
Affiliated Hospital of Yanbian University, Yanji 133000, Jilin, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19:419-21. 2007..To observe the pathological changes and investigate the correlation of hepatocyte apoptosis with cytochrome P450 2E1(CYP2E1) expression and oxygen free radical in alcoholic liver disease (ALD) in rat...
- Free radical mechanisms in immune reactions associated with alcoholic liver diseaseEmanuele Albano
Department of Medical Sciences, University Amedeo Avogadro of East Piedmont, Novara, Italy
Free Radic Biol Med 32:110-4. 2002..Altogether, these observations suggest the importance of ethanol-induced oxidative stress in stimulating immune reactions towards both liver allo-and self-antigens...
- S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient dietJesus A Villanueva
Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
Alcohol Clin Exp Res 31:1934-43. 2007....
- Developments in liver transplantationJ Neuberger
The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
Gut 53:759-68. 2004
- Methionine synthase. a possible prime site of the ethanolic lesion in liverAnthony J Barak
Liver Study Unit and V A Alcohol Research Center, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
Alcohol 26:65-7. 2002....
- Alcohol in hepatocellular cancerMichael D Voigt
4553E JCP, 200 Hawkins Drive, Iowa City, IA 52245, USA
Clin Liver Dis 9:151-69. 2005..This review summarizes the epidemiologic evidence for the role of alcohol in hepatocellular cancer, and discusses the mechanisms involved in the promotion of cancer...
- De Ritis ratio as diagnostic marker of alcoholic liver diseaseShankhar Majhi
Department of Clinical Laboratory Services Biochemistry Unit, B P Koirala Institute of Health Sciences, Ghopa Dharan Nepal
Nepal Med Coll J 8:40-2. 2006Patients suffering from Alcoholic Liver Diseases (ALD) are often diagnosed by spectrum of physical manifestations and laboratories abnormalities...
- Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver DiseaseJaana Latvala
Department of Laboratory Medicine and Addiction Research Unit, EP Central Hospital, Seinajoki, and University of Tampere, Finland
Am J Gastroenterol 100:1303-10. 2005..Excessive alcohol consumption is associated with the generation of antibodies against neoantigens induced by ethanol metabolism. However, the associations between such immune responses, ethanol consumption, and liver injury remain unclear...
- Recent advances in alcohol-induced adduct formationThomas L Freeman
University of Nebraska Medical Center and the Veterans Administration Medical Center, Omaha, Nebraska, USA
Alcohol Clin Exp Res 29:1310-6. 2005
- Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseasesFuminori Hirano
Second Department of Internal Medicine, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa, 078 8510, Japan
J Hepatol 38:483-9. 2003..concentration of plasma tumor necrosis factor alpha (TNF-alpha) correlates with the clinical course of alcoholic liver diseases. In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with ..
- Malondialdehyde-acetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cellsK K Kharbanda
VA Alcohol Research Center, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
Alcohol 25:123-8. 2001..These findings indicate that MAA-adducted proteins may play a role in the modulation of the hepatic inflammatory response and could contribute to the pathogenesis of alcoholic liver disease...
- Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injuryO Niemela
EP Central Hospital Laboratory, Seinajoki, Finland
Free Radic Biol Med 31:1533-8. 2001..Elevated adduct levels also occur in erythrocytes of alcoholics, which may be related to ethanol-induced morphological aberrations in hematopoiesis...
- Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumptionGeoffrey M Thiele
Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, OH, USA
Methods Mol Biol 447:235-57. 2008..In this chapter, methods for the production and detection of these modified proteins will be discussed...
- Hepatic encephalopathy--a serious complication of alcoholic liver diseaseRoger F Butterworth
Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Canada
Alcohol Res Health 27:143-5. 2003....
- Dysregulation of systemic iron metabolism in alcoholic liver diseasesYutaka Kohgo
Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
J Gastroenterol Hepatol 23:S78-81. 2008b>Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently, the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been clarified in detail...
- The chemistry and biological effects of malondialdehyde-acetaldehyde adductsG M Thiele
Departments of Internal Medicine, Pathology Microbiology, University of Nebraska Medical Center, and the Omaha VA Medical Center, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 25:218S-224S. 2001..Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduct and its significance in alcoholic liver injury and ALDH2 heterozygotes, by Naruhiko Nagata...
- The epidemiology of alcoholic liver diseaseRobert E Mann
Department of Social, Prevention and Health Policy Research at the Centre for Addiction and Mental Health, Toronto, Canada
Alcohol Res Health 27:209-19. 2003....
- Increased serum levels of macrophage migration inhibitory factor in alcoholic liver diseases and their expression in liver tissuesT Kumagi
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan
Clin Biochem 34:189-93. 2001OBJECTIVES: To study the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of alcoholic liver diseases. DESIGN AND METHODS: The levels of MIF in the sera were estimated by an enzyme-linked immunosorbent assay in 13 ..
- Hepatitis C virus and alcoholLarry Siu
Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
Semin Liver Dis 29:188-99. 2009..Clinical studies are needed to optimize treatment responses in alcoholic patients with chronic HCV infection...
- Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementationSun J Kim
College of Pharmacy, Seoul National University, San 56 1 Shinrim Dong, Kwanak Ku, Seoul 151 742, Republic of Korea
Biochem Biophys Res Commun 368:893-8. 2008..The results suggest that betaine may protect the liver against ethanol-induced oxidative injury most probably via its effects on the sulfur-amino acid metabolism...
- Alcohol induced hepatic fibrosis: role of acetaldehydeTommaso Mello
Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
Mol Aspects Med 29:17-21. 2008..S., 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257, 59-84]. This review will focus on the molecular mechanisms by which acetaldehyde promote liver fibrosis...
- Psychiatric differences between liver transplant candidates with familial amyloid polyneuropathy and those with alcoholic liver diseaseDiogo Telles-Correia
University of Lisbon, Lisbon, Portugal
Prog Transplant 18:134-9. 2008..Also, nonadherence before the transplant is predictive of nonadherence after the transplant...
- Review article: current management of alcoholic liver diseaseS Tome
Liver Unit, Internal Medicine Department, Complejo Hospitalario Universitario de Santiago de Compostela, Spain
Aliment Pharmacol Ther 19:707-14. 2004..Consequently, liver transplantation remains an ultimate option for selected patients with liver failure due to chronic alcoholic liver damage...
- Nf-kappab activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver diseaseK Jokelainen
Department of Pathology, Harvard Medical School, Boston, MA, USA
Cytokine 16:36-9. 2001..Thus, activation of NF-kappaB, associated with elevated mRNA levels of pro-inflammatory stimuli, precedes the histopathological liver changes in experimental alcoholic liver disease in rats...
- Treatment of alcoholic liver diseaseIna Bergheim
Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
Dig Dis 23:275-84. 2005..Treatment of the complications of ALD can improve the quality of life and, in some cases, decrease short-term mortality...
- Iron accumulation in alcoholic liver diseasesYutaka Kohgo
Third Department of Internal Medicine, Asahikawa Medical College, and Fourth Department of Internal Medicine, Sapporo Medical University, Japan
Alcohol Clin Exp Res 29:189S-93S. 2005..In patients with alcoholic liver diseases (ALD), liver iron is increased and the resulted lipid metabolite 4-hydroxynonenal-protein adduct was also ..
- Severe alcohol-induced liver disease and the alcohol dependence syndromeStewart Smith
Liver Unit, University of Southampton Medical School and Southampton University Hospitals Trust, UK
Alcohol Alcohol 41:274-7. 2006....
- Alcohol: who is at risk?Nick Sheron
Southampton General Hospital and University of Southampton Medical School
Practitioner 249:694, 696, 698-701. 2005
- Cytologic alterations in the oral mucosa after chronic exposure to ethanolSilvia Regina de Almeida Reis
Department of Propaedeutics and Integrated Clinic, School of Dentistry, Federal University of Bahia
Braz Oral Res 20:97-102. 2006..05; Spearman). In conclusion, chronic exposure to ethanol may be associated with carcinogenic cytologic changes in the oral mucosa, even in the absence of tobacco smoking. These alterations were not correlated with hepatobiliary injury...
- Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stressZhanxiang Zhou
University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
Am J Pathol 166:1681-90. 2005..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways...
- The effect of rotenone on the urinary ethanol cycle in rats fed ethanol intragastricallyJ Li
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 77:210-3. 2004..When this fluctuation is blocked by rotenone, the cycle does not occur. It is concluded that the urinary ethanol cycle is dependent on cyclic fluctuation of the NAD/NADH ratio, which regulates the rate of ethanol elimination...
- Relationships between nutrition, alcohol use, and liver diseaseCharles S Lieber
Mount Sinai School of Medicine, Bronx, New York, USA
Alcohol Res Health 27:220-31. 2003..New agents currently are being studied as promising nutritional supplements for alcoholics with liver disease...
- Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potentialZili Dan
Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
FASEB J 19:845-7. 2005..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
- RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damagePranoti Mandrekar
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Alcohol Clin Exp Res 29:1744-8. 2005....
- Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigsFarah Esfandiari
Department of Internal Medicine, University of California Davis, Davis, California 95616, USA
Am J Physiol Gastrointest Liver Physiol 289:G54-63. 2005....
- Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver diseaseUdayan M Apte
Department of Pathobiology, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
Toxicol Pathol 32:567-76. 2004..These data suggest the transient decline in liver injury during alcoholic steatosis is due to enhanced NF-kappaB-dependent hepatocyte proliferation...
- Recent events in alcoholic liver disease V. effects of ethanol on liver regenerationAnna Mae Diehl
Department of Medicine, Duke University, Durham, NC 27710, USA
Am J Physiol Gastrointest Liver Physiol 288:G1-6. 2005..Delineation of these mechanisms and clarification of how ethanol influences them might suggest new therapies for alcoholic liver disease...
- Signal transduction in alcohol-related diseasesMinoti V Apte
Pancreatic Research Group, The University of New South Wales, Sydney, Australia
Alcohol Clin Exp Res 29:1299-1309. 2005
- Ethanol-induced dysfunction of hepatocytes and leukocytes in patients without liver failureMihaela Gheorghiu
Carol Davila University of Medicine and Pharmacy, Bucharest, Pathophysiology and Immunology Department, Romania
Roum Arch Microbiol Immunol 63:5-33. 2004....
- An in vitro method of alcoholic liver injury using precision-cut liver slices from ratsLynell W Klassen
Experimental Immunology Laboratory, University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology, 983025 Nebraska Medical Center, Omaha, NE 68198 3025, USA
Biochem Pharmacol 76:426-36. 2008..Therefore, this model system appears to mimic the ethanol-induced changes in the liver that have been previously reported in human and animal studies, and may be a useful model for the study of alcoholic liver disease...
- Isolation of Kupffer cells from rats fed chronic ethanolMegan R McMullen
Department Pathobiology, Cleveland Clinic, Cleveland, OH, USA
Methods Mol Biol 447:199-212. 2008..The isolation and culture of Kupffer cells is an important technique with which one can elucidate the mechanisms that contribute to alcoholic liver injury...
- A voluntary oral-feeding rat model for pathological alcoholic liver injuryGeorge L Tipoe
Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
Methods Mol Biol 447:11-31. 2008....
- Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver diseaseSamir Zakhari
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
Hepatology 46:2032-9. 2007..A better understanding of these relationships will guide hepatologists in managing alcoholic liver disease...
- Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liverIgor Bykov
National Public Health Institute, Departments of Mental Health and Alcohol Research, POB 33, 00250 Helsinki, Finland
Clin Immunol 124:213-20. 2007..Lipocalin-2 and SPARC emerge as new candidate markers for early detection of liver damage...
- Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutritionJanuary N Baumgardner
Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Am J Physiol Gastrointest Liver Physiol 293:G355-64. 2007..However, enhanced ethanol-induced cellular proliferation, perhaps as a result of enhanced PPAR-alpha signaling, may contribute to an increased risk of hepatocellular carcinoma in undernourished alcoholics...
- Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated ratsSeda Yalçinkaya
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
Exp Toxicol Pathol 58:455-9. 2007..Our results show that HM diet may augment hepatotoxicity and oxidative stress in the liver of chronically ethanol-treated rats...
- Modulation of lecithin activity by vitamin-B complex to treat long term consumption of ethanol induced oxidative stress in liverSubir Kumar Das
Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P O Cochin 682 026, India
Indian J Exp Biol 44:791-801. 2006..Furthermore, preventive measures were more effective than curative treatment. Prevention of oxidative and nitrosative stress along with correction of nutritional deficiency is one of the proposed mechanisms for the therapeutic approach...
- Epigenetic effects of ethanol on liver and gastrointestinal injuryShivendra D Shukla
World J Gastroenterol 12:5265-71. 2006..Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential...
- Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicityVairappan Balasubramaniyan
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India
J Pharm Pharmacol 58:1113-9. 2006..These findings were consistent with our histological observations, confirming that leptin enhanced liver ailments in ethanol-supplemented mice...
- The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injuryPornpen Pramyothin
Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
J Ethnopharmacol 107:361-4. 2006..o.) enhanced liver cell recovery by bringing the levels of AST, ALT, IL-1beta back to normal. Histopathological studies confirmed the beneficial roles of PE and SL against ethanol induced liver injury in rats...
- Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female ratsTerrence M Donohue
Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 31:1944-52. 2007..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid...
- [Protective effects of bicyclol on alcohol-induced liver damage in mice]Cheng lin Mo
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
Zhonghua Yi Xue Za Zhi 85:3409-13. 2005..To study the protective effect of bicyclol on alcohol-induced liver injury in mice...
- Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathioneJingxiang Bai
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 281:5128-36. 2006..The accumulation of CYP2E1 in hepatic mitochondria induced by ethanol consumption might play an important role in alcohol liver disease...
- Oxidative stress and signal transduction pathways in alcoholic liver diseaseTomas Zima
Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Alcohol Clin Exp Res 29:110S-115S. 2005..We are only at the beginning .....
- The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88Istvan Hritz
Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
Hepatology 48:1224-31. 2008..However, the induction of IRF7, an IRF3-inducible gene, was found in Kupffer cells of alcohol-fed WT mice. Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner...
- Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damageTamie Nakajima
Department of Hygiene and Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Hepatology 40:972-80. 2004..Humans may be more susceptible to liver toxicity induced by ethanol as PPARalpha expression in human liver is considerably lower compared to that of rodents...
- Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damageKengathevy Morgan
VA Medical Center, 5901 E Seventh Street, Long Beach, CA 90822, USA
Hepatology 36:122-34. 2002..In conclusion, we have produced a transgenic mouse that expresses human CYP2E1 in the liver. When fed a nutritionally complete alcohol diet, transgenic mice develop more liver damage than nontransgenic mice...
- Hemochromatosis and alcoholic liver diseaseLinda M Fletcher
Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Alcohol 30:131-6. 2003..In addition, the cumulative effects of other forms of liver injury may result when iron and alcohol are present concurrently. Clearly, the addition of dietary iron in subjects homozygous for hemochromatosis would be unwise...
- Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?Tracey A Rouault
Section on Human Iron Metabolism, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
Alcohol 30:103-6. 2003..However, it is not known why hepatic iron accumulation occurs or how it contributes to disease progression. In this review, information about the role of iron in the pathophysiology of liver disease is reviewed and discussed...
- [Alcoholic liver disease]Marek Waluga
Katedry i Kliniki Gastroenterologii Slaskiej Akademii Medycznej w Katowicach
Wiad Lek 56:61-70. 2003..Apart from abstinence, the treatment of alcohol liver disease is based on hyperalimentation, since alcoholism is generally associated with protein malnutrition. In severe forms of alcohol hepatitis corticosteroids are recommended...
- ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout miceH Kono
Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7365, USA
Am J Physiol Gastrointest Liver Physiol 280:G1289-95. 2001..These data demonstrate that ICAM-1 and infiltrating leukocytes play important roles in early alcohol-induced liver injury, most likely by mechanisms involving TNF-alpha...
- A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunctionShannon M Bailey
Department of Environmental Health Sciences and Center for Free Radical Biology, School of Public Health, The University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
Free Radic Res 37:585-96. 2003....
- Ethanol and oxidative stressA Y Sun
Department of Pharmacology (AYS, GYS, University of Missouri, Columbia, Missouri 65212, USA
Alcohol Clin Exp Res 25:237S-243S. 2001..Sun and Grace Y. Sun...
- The antiestrogen toremifene protects against alcoholic liver injury in female ratsH A Järveläinen
National Public Health Institute, Alcohol Research Center, Helsinki, Finland
J Hepatol 35:46-52. 2001..Females are generally considered to be more susceptible to alcohol-induced liver injury than males. To elucidate whether gonadal hormones are involved, female rats were chronically treated with ethanol and with an antiestrogen...
- [Influence of ethanol on oxidative stress in the liver]Elzbieta Skrzydlewska
Zakład Chemii Nieorganicznej i Analitycznej, Akademia Medyczna w Białymstok
Przegl Lek 59:848-53. 2002..It intensifies free radical action on cell compartments which are characterized by oxidative modification of lipids, proteins and nucleic acids. These cytotoxic processes may finally lead to alcoholic liver injury in the end...
- Protective and alleviative effects from 4 cysteine-containing compounds on ethanol-induced acute liver injury through suppression of oxidation and inflammationSheng Lei Yan
Div of Gastroenterology, Dept of Internal Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
J Food Sci 72:S511-5. 2007..05). These results support that SEC and SPC could provide both preventive and alleviative effects against alcohol-induced hepatotoxicity through suppression of oxidation and inflammation...
- Role of leptin on alcohol-induced oxidative stress in Swiss miceV Balasubramaniyan
Department of Biochemistry, Annamalai University, Annamalainagar 608002, Tamilnadu, India
Pharmacol Res 47:211-6. 2003..It is postulated that the increase in systemic leptin levels enhance the oxidative stress, and lower the antioxidant defence, leading to augmented hepatic inflammation in alcoholic liver disease...
- Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteinsFeng Hong
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
Oncogene 21:32-43. 2002..These findings suggest that elevated serum IL-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6-mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis by induction of Bcl-2 and Bcl-x(L)...
- Metallothionein protection against alcoholic liver injury through inhibition of oxidative stressZhanxiang Zhou
Departments of Medicine, Pharmacology, and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202 Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202
Exp Biol Med (Maywood) 227:214-22. 2002..In conclusion, MT is an effective agent in cytoprotection against alcohol-induced liver injury, and hepatic protection by MT is likely through inhibition of alcohol-induced oxidative stress...
- The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae)Shih Chang Lee
Department of Food Science, National Chung Hsing University, Taichung, Taiwan, ROC
Am J Chin Med 30:609-16. 2002....
- Alcohol use and HIV pharmacotherapyThomas F Kresina
National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
AIDS Res Hum Retroviruses 18:757-70. 2002....
- The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in ratsFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, Torrance, California 90509, USA
Gastroenterology 123:325-35. 2002..The question is how the liver differs at the peaks and troughs of the UAL cycle. Hypoxic injury is postulated to occur at the peaks. Therefore, liver injury may be different at the peaks and troughs...
- Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcoholS Fleming
Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Alcohol Clin Exp Res 25:579-89. 2001..Collectively, these studies suggest that both pro- and anti-inflammatory soluble mediators in the intestine maintain and exacerbate the local hepatic response to ethanol...
- Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1M K Aleynik
Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
Biochem Biophys Res Commun 288:1047-51. 2001..DLPC decreases ethanol-induced CYP2E1 and should be considered for the prevention of alcoholic liver disease...
- Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in miceM Yin
Laboratory of Hepatobiology, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Gastroenterology 117:942-52. 1999..To obtain clear evidence for or against the hypothesis that TNF-alpha is involved, we studied TNF receptor 1 (TNF-R1, p55) or 2 (TNF-R2, p75) knockout mice...
- Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid dietsMartin J J Ronis
Department of Pharmacology and Toxicology, UAMS, Arkansas Children s Nutrition Center, Little Rock Arkansas, 72205, USA
Exp Biol Med (Maywood) 229:351-60. 2004....
- Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane compositionMartin J J Ronis
Arkansas Children s Nutrition Center, Department of Pharmacology Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Nutr 134:904-12. 2004..These findings may be important in the nutritional management and treatment of alcoholic liver disease...
- [Alcohol-induced gastrointestinal diseases]Ferenc Szalay
Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
Orv Hetil 144:1659-66. 2003..Metabolites, mainly acetaldehyde and free radicals are responsible for the injury. Although the alcohol itself is not carcinogenic, some maligancies are more common among alcoholics...
- Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injuryLaura E Nagy
Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 4906, USA
Annu Rev Nutr 24:55-78. 2004....
- Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated ratsJeong Sook Lee
Department of Food and Nutrition, Kosin University, Busan 606 701, South Korea
Clin Chim Acta 347:121-8. 2004..Water extract of Pueraria radix (PRWE), traditional oriental medicinal plant, may have an effect on the activity of hepatic antioxidant enzymes and lipid profile in ethanol-treated rats...
- Infiltrating polymorphonuclear leukocytes and apoptotic bodies derived from hepatocytes but not from ballooning hepatocytes containing Mallory bodies show nuclear DNA fragmentation in alcoholic hepatitisT Takahashi
Third Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
Alcohol Clin Exp Res 24:68S-73S. 2000..The mechanism of liver cell death in alcoholic hepatitis is still controversial. There is evidence that polymorphonuclear leukocytes (PMNs) which infiltrate liver parenchyma are involved in liver cell death...
- Serum intercellular adhesion molecule-1 in patients with nonalcoholic steatohepatitis: comparison with alcoholic hepatitisShuji Ito
Department of Internal Medicine, Atsugi Municipal Hospital, Kanagawaken, Japan
Alcohol Clin Exp Res 31:S83-7. 2007..In this study, we clarified the significance of serum ICAM-1 levels in patients with NAFLD, and especially in NASH...
- Scanning electron microscopic studies on morphological abnormalities of erythrocytes in alcoholic liver diseasesS Takashimizu
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
Alcohol Clin Exp Res 24:81S-86S. 2000..We previously reported that morphological abnormalities and the altered deformability of erythrocytes play important roles in disturbances of hepatic microcirculation associated with alcoholic liver disease...
- Serum ubiquitin-protein conjugates in normal subjects and patients with alcoholic liver diseases: immunoaffinity isolation and electrophoretic mobilityMasaru Takagi
Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Alcohol Clin Exp Res 26:1692-6. 2002....
- Platelet activation in patients with alcoholic liver diseaseFusao Ogasawara
Department of Internal Medicine, Tokai University School of Medicine, Hachioji Hospital, 1838 Ishikawa machi, Hachioji, Tokyo 192 0032, Japan
Tokai J Exp Clin Med 30:41-8. 2005To elucidate the mechanisms of thrombocytopenia in alcoholic liver diseases, we investigated activation status of platelets in patients with alcoholic fatty liver (Al-FL), alcoholic liver cirrhosis (Al-LC) or hepatitis-C liver cirrhosis C ..
- Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control studyHenning Grønbaek
Department of Medicine V, Aarhus University Hospital, Denmark
BMC Gastroenterol 8:16. 2008..Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases...
- A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodiesKiyoko Hirano
Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
Histochem Cell Biol 132:293-304. 2009..keratin-rich inclusion bodies observed in human alcoholic liver disease and in several chronic non-alcoholic liver diseases. The mechanism of their formation and their relationship to other inclusion bodies such as aggresomes is ..
- [Effect of tea polyphenols on expression of nuclear factor kappa B]Yuan ting Tang
Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China
Zhonghua Gan Zang Bing Za Zhi 17:301-5. 2009To investigate the effect of tea polyphenols (TP) on expression of nuclear factor kappa B (NF-kB) in rats with alcoholic liver diseases and in cells treated with alcohol.
Research Grants117 found, 100 shown here
- BASES OF CIRRHOSIS IN ALCOHOLIC LIVER DISEASEMark Zern; Fiscal Year: 2000..Health Relatedness: It is hoped that by better understanding the molecular bases of alcoholic liver diseases, effective and rational therapy can be developed.
- Synergistic Nutraceutical Effects of DLPC and SAMeCharles Lieber; Fiscal Year: 2007....
- Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol DrinkersCharles Lieber; Fiscal Year: 2007..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. ..
- Liver Fibrosis, Inflammation & Oxidative Stress MarkersCharles Lieber; Fiscal Year: 2006..abstract_text> ..
- DLPC Treatment of Alcoholic and Non-Alcoholic FibrosisCharles Lieber; Fiscal Year: 2006..abstract_text> ..
- ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERSCharles Lieber; Fiscal Year: 2005..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
- MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATIONCharles Lieber; Fiscal Year: 2001..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
- DLPC TREATMENT OF ALCOHOLIC AND NON ALCOHOLIC FIBROSISCharles Lieber; Fiscal Year: 2000..If successful, the proposed studies will establish DLPC as the first safe and chemically defined agent capable of preventing the progression (and possibly of promoting the regression) of hepatic and pulmonary fibrosis. ..
- INTERACTION OF ETHANOL WITH HEPATIC MICROSOMESCharles Lieber; Fiscal Year: 1992..Our ultimate goal is to define in molecular terms some of the most far-reaching changes brought about by chronic ethanol consumption in the internal milieu of the body and the resulting response to the environment...
- S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver DiseaseCraig McClain; Fiscal Year: 2007..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
- Planning Grant for Louisville Clinical and Translational Science AwardCraig McClain; Fiscal Year: 2006..Expand and integrate a clinical and translational research resources and outreach network. ..
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig McClain; Fiscal Year: 2009..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
- Mechanisms of S-adenosylmethionine in NASHCraig McClain; Fiscal Year: 2009..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
- The Role of Alcohol in HIV Therapy HepatotoxicityCRAIG J contact MCCLAIN; Fiscal Year: 2010..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
- A.S.P.E.N. Research Workshop on Functional FoodsCraig McClain; Fiscal Year: 2002..abstract_text> ..
- The Role of Alcohol in HIV Therapy HepatotoxicityCraig McClain; Fiscal Year: 2009..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
- Homocysteine, ER stress and alcoholic liver injuryNeil Kaplowitz; Fiscal Year: 2007..We anticipate that we will obtain important new knowledge which can be applied to the prevention and treatment of ALD ..
- Effects of ethanol and CYP2E1 on liver functionArthur Cederbaum; Fiscal Year: 2007....
- Role of Mitochondria in the Regulation of Iron metabolism by AlcoholDUYGU DEE DEE HARRISON FINDIK; Fiscal Year: 2010..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..
- Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.Arthur I Cederbaum; Fiscal Year: 2010..Identification of downstream effectors of alcohol/CYP2E1 actions would be very informative in developing therapeutic interventions against alcohol-induced liver injury and fatty liver. ..
- The Role of Alcohol in HIV Therapy HepatotoxicityCraig McClain; Fiscal Year: 2009..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
- Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.Arthur Cederbaum; Fiscal Year: 2009..Identification of downstream effectors of alcohol/CYP2E1 actions would be very informative in developing therapeutic interventions against alcohol-induced liver injury and fatty liver. ..
- TNF and Mitochondrial Dysfunction in ALDCraig McClain; Fiscal Year: 2007..abstract_text> ..
- Degradation of Human CYP2E1 by the ProteasomeArthur Cederbaum; Fiscal Year: 2004..Modulators of any of these newly identified steps may have therapeutic implications for individuals with high levels of CYP2E1. ..
- ALCOHOL OXYGEN RADICAL INTERACTIONS AS DETECTED BY ESRArthur Cederbaum; Fiscal Year: 2001..These studies will provide new information on the ability of NO to modulate CYP2El catalytic activity, generation of reactive intermediates, and ethanol and PUFA toxicity. ..
- ALCOHOL AND PYRAZOLE REACTION AND METABOLISM BY CYP2E1Arthur Cederbaum; Fiscal Year: 2002..It is hoped that these studies will help to define the role of CYP2E1 and CYP2E1-derived reactive oxygen species in the hepatotoxic actions of ethanol. ..
- ALCOHOL AND PYRAZOLE REACTION AND METABOLISM BY CYP2E1Arthur Cederbaum; Fiscal Year: 2006..It is hoped that such studies in hepatocyte and HepG2 cell culture models and in-vivo models, will help to define further the biochemical and toxicological actions of CYP2E1 and its role in alcohol-induced liver injury. ..
- PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVERNeil Kaplowitz; Fiscal Year: 1991..Understanding of the process of sinusoidal efflux of GSH will permit future determination of the influence of liver disease on the homeostasis of this vital substance...
- Zinc and Alcohol-Induced Oxidative Liver InjuryZhanxiang Zhou; Fiscal Year: 2009..These studies will provide fundamental understanding of the role of zinc in the pathophysiology of ALD, and pave the way to novel therapeutical approaches to prevention and treatment of this disease. ..
- REGULATION OF S-ADENOSYLMETHIONINE SYNTHETASE IN LIVERShelly Lu; Fiscal Year: 2000..It is hoped that these studies would enhance our knowledge of a key cellular enzyme and offer possible therapeutic approaches against a cancer that currently lacks effective treatment. ..
- Metallothionein in Chronic Alcoholic Liver InjuryZhanxiang Zhou; Fiscal Year: 2004..These studies will provide fundamental understanding of the role and possible clinical application of MT in cytoprotection against chronic alcohol-induced liver injury, a major clinical health problem without FDA approved therapy. ..
- REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVERShelly Lu; Fiscal Year: 2009..Our overall goals are to better understand regulation and function of hepatic MAT genes, and to develop novel therapies against abnormal liver growth. ..