gastroparesis

Summary

Summary: Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

Top Publications

  1. pmc Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
    Henry P Parkman
    Gastroenterology Section, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 140:101-15. 2011
  2. ncbi Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis
    Viktor J Horváth
    Department of Physiology and Cell Biology, University of Nevada, Reno, Nevada, USA
    Gastroenterology 130:759-70. 2006
  3. pmc Epidemiology, mechanisms, and management of diabetic gastroparesis
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN, USA
    Clin Gastroenterol Hepatol 9:5-12; quiz e7. 2011
  4. ncbi Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms
    Dennis A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, MD 20814, USA
    Qual Life Res 13:833-44. 2004
  5. ncbi Gastric neuromuscular pathology in gastroparesis: analysis of full-thickness antral biopsies
    Justin Harberson
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 55:359-70. 2010
  6. pmc The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006
    Hye Kyung Jung
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 136:1225-33. 2009
  7. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010
  8. pmc Cellular changes in diabetic and idiopathic gastroparesis
    Madhusudan Grover
    Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 140:1575-85.e8. 2011
  9. pmc Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management
    N Zarate
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain
    Gut 52:966-70. 2003
  10. pmc Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans
    M Grover
    Mayo Clinic, Rochester, MN, USA
    Neurogastroenterol Motil 24:844-52. 2012

Detail Information

Publications253 found, 100 shown here

  1. pmc Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
    Henry P Parkman
    Gastroenterology Section, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 140:101-15. 2011
    Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity...
  2. ncbi Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis
    Viktor J Horváth
    Department of Physiology and Cell Biology, University of Nevada, Reno, Nevada, USA
    Gastroenterology 130:759-70. 2006
    Diabetic gastroparesis involves neuropathy, myopathy, and depletion of interstitial cells of Cajal (ICC), which may cause dysrhythmias and impaired neural control...
  3. pmc Epidemiology, mechanisms, and management of diabetic gastroparesis
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN, USA
    Clin Gastroenterol Hepatol 9:5-12; quiz e7. 2011
    Recent evidence of the significant impact of gastroparesis on morbidity and mortality mandates optimized management of this condition...
  4. ncbi Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms
    Dennis A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, MD 20814, USA
    Qual Life Res 13:833-44. 2004
    Patient-rated symptom assessments are needed for evaluating the effectiveness of medical treatments and for monitoring outcomes in gastroparesis.
  5. ncbi Gastric neuromuscular pathology in gastroparesis: analysis of full-thickness antral biopsies
    Justin Harberson
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 55:359-70. 2010
    Pathologic assessment of gastric tissue in patients with gastroparesis is limited. Aims To evaluate gastric histopathology in patients with gastroparesis.
  6. pmc The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006
    Hye Kyung Jung
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 136:1225-33. 2009
    The epidemiology of gastroparesis is unknown. We aimed to determine the incidence, prevalence, and outcome of gastroparesis in the community.
  7. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010
    Despite the relatively high prevalence of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood...
  8. pmc Cellular changes in diabetic and idiopathic gastroparesis
    Madhusudan Grover
    Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 140:1575-85.e8. 2011
    Cellular changes associated with diabetic and idiopathic gastroparesis are not well described...
  9. pmc Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management
    N Zarate
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain
    Gut 52:966-70. 2003
    ..In the absence of an identified cause, gastroparesis is labelled as idiopathic. We present the case of a patient with severe idiopathic gastroparesis...
  10. pmc Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans
    M Grover
    Mayo Clinic, Rochester, MN, USA
    Neurogastroenterol Motil 24:844-52. 2012
    ..The aims of this study were to determine the morphology and distribution of PDGFRα-immunoreactive (ir) FLC in human gastric muscle and to determine if FLC are altered in gastroparesis, where ICC are reduced.
  11. ncbi Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study
    Richard W McCallum
    University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Gastroenterol Hepatol 8:947-54; quiz e116. 2010
    Gastric electrical stimulation (GES) treats refractory gastroparesis by delivering electric current, via electrodes, to gastric smooth muscle...
  12. ncbi Gastric electrical stimulation improves outcomes of patients with gastroparesis for up to 10 years
    Richard W McCallum
    Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Clin Gastroenterol Hepatol 9:314-319.e1. 2011
    We assessed the long-term clinical outcomes of gastric electrical stimulation (GES) therapy with Enterra (Enterra Therapy System; Medtronic, Minneapolis, MN) in a large cohort of patients with severe gastroparesis.
  13. pmc Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years
    Purna Kashyap
    Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Gut 59:1716-26. 2010
    Diabetic gastroparesis is a disorder that occurs in both type 1 and type 2 diabetes. It is associated with considerable morbidity among these patients and with the resultant economic burden on the health system...
  14. pmc Similarities and differences between diabetic and idiopathic gastroparesis
    Henry P Parkman
    Temple University, School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 9:1056-64; quiz e133-4. 2011
    b>Gastroparesis can be diabetic or idiopathic, yet little is known about differences in their presentation...
  15. pmc Altered expression of Ano1 variants in human diabetic gastroparesis
    Amelia Mazzone
    Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 286:13393-403. 2011
    ..gastrointestinal pacemaker cells, underlie a number of gastrointestinal motility disorders, including diabetic gastroparesis. In the muscle layers, ICC selectively express Ano1, thought to underlie classical Ca(2+)-activated Cl(-) ..
  16. ncbi Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity
    W L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Neurogastroenterol Motil 21:229-43. 2009
    ..gastric electrical activity, eliciting propagating contractions and reducing symptomatology in patients with gastroparesis and reducing appetite and food intake in individuals with morbid obesity...
  17. ncbi Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms
    Catalin Sfarti
    University of Medicine and Pharmacy Gr T Popa, Iasi, Romania
    J Gastrointestin Liver Dis 19:279-84. 2010
    b>Gastroparesis and/or dyspeptic symptoms occur in around 50% of type 1 diabetic patients...
  18. pmc Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis
    Kyoung Moo Choi
    Enteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 135:2055-64, 2064.e1-2. 2008
    Diabetic gastroparesis (delayed gastric emptying) is a well-recognized complication of diabetes that causes considerable morbidity and makes glucose control difficult...
  19. ncbi Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
    N Ejskjaer
    Aarhus University, Aarhus, Denmark
    Neurogastroenterol Motil 22:1069-e281. 2010
    b>Gastroparesis, a chronic disorder of abnormal gastric motility, is common in patients with diabetes mellitus. A synthetic, selective ghrelin receptor agonist, TZP-101, is in clinical development for treatment of gastroparesis...
  20. ncbi Temporary gastric electrical stimulation with orally or PEG-placed electrodes in patients with drug refractory gastroparesis
    Srinivasa Ayinala
    Division of Digestive Diseases, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Gastrointest Endosc 61:455-61. 2005
    Gastric electrical stimulation (GES) has been shown to be efficacious for drug refractory gastroparesis, but GES requires surgery...
  21. ncbi Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data
    J M Wo
    Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, USA
    Aliment Pharmacol Ther 33:679-88. 2011
    Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake...
  22. pmc Clinical guideline: management of gastroparesis
    Michael Camilleri
    Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 108:18-37; quiz 38. 2013
    This guideline presents recommendations for the evaluation and management of patients with gastroparesis. Gastroparesis is identified in clinical practice through the recognition of the clinical symptoms and documentation of delayed ..
  23. pmc Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
    Factors associated with abdominal pain in gastroparesis are incompletely evaluated and comparisons of pain vs other symptoms are limited...
  24. pmc Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population
    Rok Seon Choung
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:82-8. 2012
    In patients with diabetes mellitus (DM) and upper gastrointestinal symptoms, a diagnosis of diabetic gastroparesis is often considered, but population-based data on the epidemiology of diabetic gastroparesis are lacking...
  25. ncbi Evaluating symptom outcomes in gastroparesis clinical trials: validity and responsiveness of the Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD)
    D A Revicki
    United BioSource Corporation, Bethesda, MD 20814, USA
    Neurogastroenterol Motil 24:456-63, e215-6. 2012
    Patient-reported symptom scales are needed to evaluate treatments for gastroparesis. The Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) was developed to assess daily symptoms of gastroparesis...
  26. pmc Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping
    Gregory O'Grady
    Department of Surgery, University of Auckland, Auckland, New Zealand
    Gastroenterology 143:589-98.e1-3. 2012
    ..Disrupted ICC networks and gastric dysrhythmias are each associated with gastroparesis. However, there are no data on the initiation and propagation of slow waves in gastroparesis because research ..
  27. ncbi Functional dyspepsia: mechanisms of symptom generation and appropriate management of patients
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street, SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 36:649-64, xi-x. 2007
    ..To achieve greater therapeutic efficacy, it may be necessary to target the therapeutic approach to a specific pathophysiology, such as impaired gastric emptying...
  28. ncbi Treatment of high-frequency gastric electrical stimulation for gastroparesis
    Huikuan Chu
    Division of Gastroenterology, Department of Internal Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Gastroenterol Hepatol 27:1017-26. 2012
    The aim of this study was to assess the effects of gastric electrical stimulation (GES) on symptoms and gastric emptying in patients with gastroparesis, and the effects of GES on the three subgroups of gastroparesis.
  29. pmc Carbon monoxide reverses diabetic gastroparesis in NOD mice
    Purna C Kashyap
    Mayo Clinic, 200 First St SW, Rochester MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 298:G1013-9. 2010
    Diabetic gastroparesis is associated with increased oxidative stress attributable to loss of upregulation of heme oxygenase-1 (HO1), with resultant damage to interstitial cells of Cajal and delayed gastric emptying...
  30. ncbi Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up
    Thomas Abell
    Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    JPEN J Parenter Enteral Nutr 27:277-81. 2003
    ..depletion, either macronutrient- or micronutrient-related, is common in patients with drug-refractory gastroparesis (GP) for which there is often no effective treatment...
  31. ncbi Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipation
    Braden Kuo
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Dig Dis Sci 56:2928-38. 2011
    The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.
  32. ncbi Advances in diabetic gastroparesis
    Michael Camilleri
    Gastroenterology Research Unit, Mayo Foundation, Rochester, MN, USA
    Rev Gastroenterol Disord 2:47-56. 2002
    This review addresses the advances in our understanding of the epidemiology and mechanisms in diabetic gastroparesis and dyspepsia...
  33. ncbi Malignant gastroparesis: pathogenesis and management of an underrecognized disorder
    Kavitha R Donthireddy
    Department of Medicine and Surgery, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Support Oncol 5:355-63. 2007
    b>Gastroparesis is a disorder of the stomach caused by delayed gastric emptying in the absence of mechanical obstruction. Symptoms of gastroparesis include nausea, vomiting, early satiety, bloating, and abdominal discomfort...
  34. ncbi Development and validation of a patient-assessed gastroparesis symptom severity measure: the Gastroparesis Cardinal Symptom Index
    D A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, MD 20814, USA
    Aliment Pharmacol Ther 18:141-50. 2003
    Patient-based symptom assessments are necessary to evaluate the effectiveness of medical treatments for gastroparesis.
  35. ncbi A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit
    Weidong Xie
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Eur J Pharmacol 510:113-20. 2005
    ..transit was thought to be a new tactic to treat postprandial hypertriglyceridemia in diabetic individuals with gastroparesis. Diabetic gastroparesis, lipid load testing, and the effect of domperidone or aqueous extract of rhizomes of ..
  36. ncbi Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings
    Jameson Forster
    Department of Medicine, Division of Gastrointestinal Motility, Surgery, and Pathology, University of Kansas Medical Center, Kansas City, Kansas 66160 7309, USA
    J Gastrointest Surg 9:102-8. 2005
    ..The role of these cells in gastroparesis has not been established...
  37. ncbi Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment
    Sung Wan Kim
    Department of Psychiatry, Chonnam National Univ Hospital, 8 Hak Dong, Dong Ku, Kwangju 501 757, Republic of Korea
    Psychosomatics 47:440-2. 2006
    b>Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction...
  38. ncbi Gastric electrical stimulation for medically refractory gastroparesis
    Thomas Abell
    University of Mississippi, Jackson, Mississippi, USA
    Gastroenterology 125:421-8. 2003
    This study investigated the efficacy of gastric electrical stimulation for the treatment of symptomatic gastroparesis unresponsive to standard medical therapy.
  39. pmc CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice
    Kyoung Moo Choi
    Enteric Neuroscience Program and Department of Physiology, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 138:2399-409, 2409.e1. 2010
    b>Gastroparesis is a well-recognized complication of diabetes. In diabetics, up-regulation of heme oxygenase-1 (HO1) in gastric macrophages protects against oxidative stress-induced damage...
  40. ncbi Treatment of diabetic gastroparesis by high-frequency gastric electrical stimulation
    Zhiyue Lin
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Diabetes Care 27:1071-6. 2004
    To investigate the long-term efficacy of high-frequency gastric electrical stimulation (GES) for treating diabetic gastroparesis.
  41. ncbi Treatment of gastroparesis: a multidisciplinary clinical review
    T L Abell
    University of Mississippi Medical Center, Jackson, USA
    Neurogastroenterol Motil 18:263-83. 2006
    This clinical review on the treatment of patients with gastroparesis is a consensus document developed by the American Motility Society Task Force on Gastroparesis...
  42. pmc Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis
    Pankaj J Pasricha
    Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Gastroenterol 8:21. 2008
    The pathophysiological basis of diabetic gastroparesis is poorly understood, in large part due to the almost complete lack of data on neuropathological and molecular changes in the stomachs of patients...
  43. ncbi Clinical response to gastric electrical stimulation in patients with postsurgical gastroparesis
    Richard McCallum
    Department of Medicine, Mail Stop 1058, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Clin Gastroenterol Hepatol 3:49-54. 2005
    The aim of this study was to report the long-term clinical response to high-frequency gastric electrical stimulation (GES) in 16 patients with postsurgical gastroparesis who failed standard medical therapy.
  44. ncbi Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis
    Z Lin
    Department of Medicine, University of Kansas Medical Center, Kansas City, 66160, USA
    Neurogastroenterol Motil 18:18-27. 2006
    ..5 to 7.9% at 3 years. We conclude that a significant improvement in symptoms and all measures of clinical outcome can be maintained for greater than 3 years with GES in patients with refractory gastroparesis.
  45. ncbi Gastroparesis: symptoms, evaluation, and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, University of Michigan Hospital, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 36:619-47, ix. 2007
    b>Gastroparesis presents with gastrointestinal symptoms and nongastrointestinal manifestations in association with objective delays in gastric emptying. The condition may complicate several systemic disorders or may be idiopathic in nature...
  46. ncbi Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995-2004
    Yize R Wang
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Gastroenterol 103:313-22. 2008
    b>Gastroparesis is an increasingly recognized disorder. Its prevalence in the United States is unknown. We examined the trends, characteristics, and outcomes of gastroparesis-related hospitalizations during 1995-2004.
  47. ncbi Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study
    R W McCallum
    Center for GI Nerve and Muscle Function, University of Kansas Medical Center, Kansas City, KS, USA
    Aliment Pharmacol Ther 26:1121-30. 2007
    ..Mitemcinal is an orally active motilin agonist that could potentially improve gastric emptying...
  48. pmc Predictive factors for clinical improvement with Enterra gastric electric stimulation treatment for refractory gastroparesis
    Jennifer L Maranki
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, Philadelphia, PA 19140, USA
    Dig Dis Sci 53:2072-8. 2008
    The objectives of this study were to determine the clinical response to Enterra gastric electric stimulation (GES) in patients with refractory gastroparesis and to determine factors associated with a favorable response.
  49. ncbi Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study
    C S Chang
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan
    Digestion 64:184-90. 2001
    Abnormal gastric slow-wave frequencies have been observed in diabetic gastroparesis and are associated with impaired antral motor activity...
  50. ncbi Dyspepsia and gastroparesis in chronic renal failure: the role of Helicobacter pylori
    R Schoonjans
    Department of Intemal Medicine, Ghent University Hospital, Belgium
    Clin Nephrol 57:201-7. 2002
    ....
  51. ncbi Upper abdominal symptoms in patients with Type 1 diabetes: unrelated to impairment in gastric emptying caused by autonomic neuropathy
    J Punkkinen
    Department of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Diabet Med 25:570-7. 2008
    Diabetic gastroparesis is a common condition occurring in some 30-50% of patients with long-term diabetes. Some studies have found a relationship between autonomic neuropathy and diabetic gastroparesis...
  52. ncbi Gastric pacing is a new surgical treatment for gastroparesis
    J Forster
    Department of Surgery, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7309, USA
    Am J Surg 182:676-81. 2001
    b>Gastroparesis is a chronic gastric motility disorder affecting mostly young and middle-aged women who present with nausea, abdominal pain, early satiety, vomiting, fullness, and bloating.
  53. ncbi The effect of sildenafil on gastric emptying in patients with end-stage renal failure and symptoms of gastroparesis
    V Dishy
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Clin Pharmacol Ther 76:281-6. 2004
    ..The aim of our study was to examine the hypothesis that sildenafil may improve gastric emptying in patients with ESRF and symptoms of gastric paresis...
  54. pmc Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux
    Digavalli V Sivarao
    Department of Veterans Affairs Medical Center, Center for Swallowing and Motility Disorders, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 135:1258-66. 2008
    ..Nitrergic nerves and interstitial cells of Cajal (ICC) have been implicated in the regulation of pyloric motility. The purpose of these studies was to define their roles in pyloric function in vivo...
  55. ncbi Therapeutic effects of ghrelin and growth hormone releasing peptide 6 on gastroparesis in streptozotocin-induced diabetic guinea pigs in vivo and in vitro
    Wen Cai Qiu
    Department of General Surgery, Sixth Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    Chin Med J (Engl) 121:1183-8. 2008
    Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In normal animals, both ghrelin and its synthetic peptide, growth hormone releasing peptide 6 (GHRP-6), increase gastric emptying...
  56. ncbi Obesity and symptoms suggestive of gastroparesis in patients with type 2 diabetes and neuropathy
    Mona Boaz
    Epidemiology and Research Unit, E Wolfson Medical Center, Holon, Israel
    J Diabetes Complications 25:325-8. 2011
    Associated with neuropathy, symptoms suggestive of gastroparesis are common in patients with type 2 diabetes mellitus (T2DM) and include nausea, vomiting, bloating and early satiety...
  57. ncbi The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis
    Pieter Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 108:1382-91. 2013
    ..and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain...
  58. ncbi A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis
    Chung Pang Wang
    Department of Emergency Medicine, China Medical University Hospital, Taichung City, Taiwan, Republic of China
    J Altern Complement Med 14:833-9. 2008
    The current pharmacological management of diabetic gastroparesis remains difficult. Acupuncture has been widely used for gastrointestinal symptoms...
  59. ncbi Gastric electrical stimulation is an effective and safe treatment for medically refractory gastroparesis
    Daniel McKenna
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Surgery 144:566-72; discussion 572-4. 2008
    b>Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain...
  60. ncbi The role of continuous subcutaneous insulin infusion therapy in patients with diabetic gastroparesis
    D Sharma
    The Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    Diabetologia 54:2768-70. 2011
    To describe the effectiveness of continuous subcutaneous insulin infusion (CSII) in patients with symptomatic diabetic gastroparesis and unstable glycaemic control.
  61. ncbi Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre
    T Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Br J Surg 97:1043-50. 2010
    ..Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy. The International Study Group of Pancreatic Surgery (ISGPS) definition of DGE has not been evaluated and validated in a high-volume centre...
  62. ncbi Pathophysiology and management of gastroparesis
    Joan Khoo
    Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia
    Expert Rev Gastroenterol Hepatol 3:167-81. 2009
    b>Gastroparesis is characterized by upper gastrointestinal symptoms associated with delayed gastric emptying, without mechanical obstruction. However, symptoms do not correlate well with the magnitude of delay in gastric emptying...
  63. ncbi A novel classification scheme for gastroparesis based on predominant-symptom presentation
    Steven P Harrell
    Division of Gastroenterology Hepatology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Clin Gastroenterol 42:455-9. 2008
    Symptoms of gastroparesis are very diverse. Classifying patients by predominant symptom may improve management strategy.
  64. ncbi Long-term outcome after gastrectomy for intractable diabetic gastroparesis
    P J Watkins
    King s Diabetes Centre, King s College Hospital, London, UK
    Diabet Med 20:58-63. 2003
    To examine the long-term outlook for patients with intractable vomiting from diabetic gastroparesis who underwent major gastric surgery.
  65. pmc Incidence and risk factors for postsurgical gastroparesis syndrome after laparoscopic and open radical gastrectomy
    Hongbo Meng
    Department of General Surgery, Tenth People s Hospital of Tongji University, Shanghai 200072, China
    World J Surg Oncol 11:144. 2013
    The aim of this study was to investigate the differences and influencing factors for postsurgical gastroparesis syndrome incidence after laparoscopic and open radical gastrectomy.
  66. ncbi Prevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitus
    Ram Dickman
    Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel
    J Diabetes Complications 27:376-9. 2013
    To estimate the prevalence of symptoms suggestive of gastroparesis and their association to clinical and demographic data in a large population of patients with diabetes mellitus and in the general population in Israel.
  67. ncbi Diabetic gastroparesis: recent insights into pathophysiology and implications for management
    Sony S Thazhath
    Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia Centre of Clinical Research Excellence in Nutritional Physiology, Interventions and Outcomes, University of Adelaide, Adelaide, SA, Australia
    Expert Rev Gastroenterol Hepatol 7:127-39. 2013
    ..have recently been gained by the systematic analysis of gastric biopsies from patients with severe diabetic gastroparesis, which may stimulate the development of new therapies in the coming decade...
  68. pmc Gender bias in gastroparesis: is nitric oxide the answer?
    P R R Gangula
    Department of Physiology, Center for Women s Health Research, Meharry Medical College, 1005 Dr D B Todd Jr Blvd, Nashville, TN 37208, USA
    Dig Dis Sci 56:2520-7. 2011
    ..Women are more susceptible to gastroparesis than men...
  69. pmc High-resolution entrainment mapping of gastric pacing: a new analytical tool
    Gregory O'Grady
    Department of Surgery, and Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Am J Physiol Gastrointest Liver Physiol 298:G314-21. 2010
    Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of ..
  70. ncbi Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives
    Julie E Stevens
    University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia
    Expert Opin Pharmacother 14:1171-86. 2013
    b>Gastroparesis is an important clinical disorder characterised by delayed gastric emptying in the absence of mechanical outlet obstruction. Idiopathic, diabetes and postsurgical causes represent the most common aetiologies...
  71. ncbi A double-masked, randomized, placebo-controlled trial of temporary endoscopic mucosal gastric electrical stimulation for gastroparesis
    Thomas L Abell
    Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Gastrointest Endosc 74:496-503.e3. 2011
    Endoscopically placed, temporary gastric electrical stimulation (tGES) may relieve symptoms of gastroparesis (Gp) and predict permanent gastric electrical stimulation (GES) outcomes.
  72. ncbi Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis: literature review and our experience
    John Leung
    Gastroenterology, Internal Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Dig Dis Sci 54:401-5. 2009
    ..This condition is well described in the literature and is thought to result from pancreatic cancer-associated gastroparesis (PCAG). No clinical guideline is available for diagnosing and managing this rare disease.
  73. ncbi [Diabetic gastroparesis]
    M P Stassen
    Clinique A Renard, Herstal
    Rev Med Liege 60:509-15. 2005
    Diabetic gastroparesis corresponds to symptomatic as well as asymptomatic gastric retention without organic abnormality of stomach, pylorus or gut...
  74. ncbi [New therapeutic approaches to diabetic gastroparesis]
    Michael Hummel
    Klinik fur Endokrinologie, Diabetologie und Suchtmedizin, Klinikum Schwabing, Städt Klinikum München GmbH and Institut für Diabetesforschung, Munchen
    Med Klin (Munich) 103:514-8. 2008
    ..PHYSICAL EXAMINATION: A 24-year-old man with type 1 diabetes, nonresponding to standard treatment for severe gastroparesis, was admitted to hospital due to persisting nausea and vomiting...
  75. ncbi Impact of anastomotic complications on outcome after laparoscopic gastrectomy for early gastric cancer
    Y Nagasako
    Department of Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Br J Surg 99:849-54. 2012
    ..The aims of this observational study were to identify potential factors that predict anastomotic complications and investigate the impact of anastomotic complications in patients undergoing gastrectomy for early gastric cancer...
  76. ncbi Severe gastroparesis: new treatment alternatives
    Hasse Abrahamsson
    Department of Internal Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Best Pract Res Clin Gastroenterol 21:645-55. 2007
    ..and the motilin receptor agonist erythromycin have been the cornerstones in drug treatment of severe gastroparesis for more than a decade. No new drugs have been approved for treatment of this disorder in this period...
  77. ncbi Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer
    M Nguyen-Tat
    Department of Internal Medicine II, HSK Wiesbaden, Wiesbaden, Germany
    Z Gastroenterol 46:274-8. 2008
    b>Gastroparesis is a common but challenging disorder which can be idiopathic or induced by a variety of underlying diseases, most frequently by diabetes, or post-surgical conditions of the upper abdomen...
  78. ncbi The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology
    I Sarosiek
    Center for Gastrointestinal Nerve and Muscle Function and GI Motility, University of Kansas Medical Center, Kansas City, USA
    Aliment Pharmacol Ther 31:313-22. 2010
    ..Wireless pH and pressure motility capsule (wireless motility capsule) technology provides a method to assess regional gastrointestinal transit times...
  79. pmc Two-channel gastric pacing in patients with diabetic gastroparesis
    Zhiyue Lin
    University of Kansas Medical Center, Kansas City, KS, USA
    Neurogastroenterol Motil 23:912-e396. 2011
    ..were to investigate the effects of two-channel gastric pacing on gastric myoelectrical activity, and energy consumption with the secondary intent to monitor gastric emptying and symptoms in patients with severe diabetic gastroparesis.
  80. ncbi Video: temporary gastric electrical stimulation for gastroparesis: endoscopic placement of electrodes (ENDOstim)
    Sumanth R Daram
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Surg Endosc 25:3444-5. 2011
    ..electrical stimulation (GES) to be an effective management strategy for patients with medication refractory gastroparesis. However, placement of a permanent GES device requires surgery and has considerable cost considerations...
  81. pmc Ultrastructural differences between diabetic and idiopathic gastroparesis
    Maria Simonetta Faussone-Pellegrini
    University of Florence, Florence, Italy
    J Cell Mol Med 16:1573-81. 2012
    The ultrastructural changes in diabetic and idiopathic gastroparesis are not well studied and it is not known whether there are different defects in the two disorders...
  82. ncbi Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis
    Brian Hyett
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Gastroenterology 137:445-52. 2009
    The aim of this study was to evaluate the prognostic value of gastric emptying studies on the morbidity associated with diabetic gastroparesis.
  83. pmc Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium
    M Grover
    Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:531-9, e249. 2012
    Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium...
  84. ncbi Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis
    B Braden
    Medical Department I, Hospital of the J W Goethe University, Frankfurt, Germany
    Neurogastroenterol Motil 21:632-8, e25. 2009
    ..study addressed the question of whether STW 5 accelerates gastric emptying in patients with FD and gastroparesis. One-hundred and three patients diagnosed with FD were randomly assigned to a treatment with either STW 5 or a ..
  85. ncbi Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects
    Henry P Parkman
    Gastroenterology Section, School of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:115-24. 2011
    Domperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability...
  86. ncbi Further experience with gastric stimulation to treat drug refractory gastroparesis
    Jameson Forster
    Department of Surgery, Kansas University Medical Center, Kansas City 66160 7309, USA
    Am J Surg 186:690-5. 2003
    Gastric electrical stimulation (GES) has been introduced for patients with gastroparesis refractory to pharmacological therapy.
  87. pmc Gastroparesis in patients with inactive Crohn's disease: a case series
    Jón O Kristinsson
    Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands
    BMC Gastroenterol 7:11. 2007
    ..The aim of this case series was to evaluate clinical characteristics of 5 patients with inflammatory bowel disease and symptoms and signs of upper gut dysmotility...
  88. ncbi Autonomic dysfunction and gastroparesis in cirrhosis
    G Nicholas Verne
    Divisions of Gastroenterology, Hepatology, and Nutrition, University of Florida, Malcom Randall VAMC, 1601 SW Archer Road, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:72-6. 2004
    ..The cause of these motility disorders in cirrhotics is unknown, however, underlying autonomic dysfunction may play a role...
  89. ncbi Pilot study on gastric electrical stimulation on surgery-associated gastroparesis: long-term outcome
    Benton Oubre
    University of Mississippi Medical Center, Jackson, MS, USA
    South Med J 98:693-7. 2005
    Patients with postgastric surgery gastroparesis are often unresponsive to conventional medical therapy...
  90. pmc Gastroparesis: current diagnostic challenges and management considerations
    Shamaila Waseem
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610, USA
    World J Gastroenterol 15:25-37. 2009
    b>Gastroparesis refers to abnormal gastric motility characterized by delayed gastric emptying in the absence of mechanical obstruction. The most common etiologies include diabetes, post-surgical and idiopathic...
  91. ncbi Small case series of gastric stimulation for the management of transplant-induced gastroparesis
    Lori A Filichia
    Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida 32610 0286, USA
    J Surg Res 148:90-3. 2008
    b>Gastroparesis is a recognized complication following organ transplantation with incidences reported between 24 and 83%...
  92. ncbi Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis
    David N Moskovitz
    Department of Medicine, University of Toronto and University Health Network and Mount Sinai Hospital, Toronto, Canada
    Can J Gastroenterol 16:171-4. 2002
    ..A case of SCLC with positive anti-Hu antibodies presenting with intestinal pseudo-obstruction is presented. Gastrointestinal dysmotility as a manifestation of paraneoplastic syndrome is reviewed...
  93. ncbi Malignant gastroparesis: diagnostics and therapeutics
    Satish Nagula
    Gastroenterology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Support Oncol 5:366-7. 2007
  94. ncbi Refractory gastroparesis after Roux-en-Y gastric bypass: surgical treatment with implantable pacemaker
    J R Salameh
    Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA
    J Gastrointest Surg 11:1669-72. 2007
    b>Gastroparesis is a rare complication of Roux-en-Y gastric bypass. We evaluate the role of gastric electrical stimulation in medically refractory gastroparesis.
  95. ncbi Gastric electrical stimulation with parameters for gastroparesis enhances gastric accommodation and alleviates distention-induced symptoms in dogs
    J H Xing
    Veterans Research Foundation, Oklahoma City, Oklahoma, USA
    Dig Dis Sci 51:2160-4. 2006
    Gastric electrical stimulation (GES) improves symptoms in patients with gastroparesis. We sought to determine if stimulation at fundus with parameters used for gastroparesis could affect gastric accommodation and distention-induced ..
  96. ncbi Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis
    Kishore V Gaddipati
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Dig Dis Sci 51:1339-46. 2006
    Vagal nerve dysfunction has been implicated in the pathogenesis of diabetic gastroparesis, but its role in idiopathic gastroparesis remains uncertain...
  97. ncbi Gastric electrical stimulation has an immediate antiemetic effect in patients with gastroparesis
    Babajide O Familoni
    Department of Electrical Engineering, The University of Memphis, TN 38152, USA
    IEEE Trans Biomed Eng 53:1038-46. 2006
    ..Electrical stimulation has been successfully employed to treat diseases involving electro-pathology in the heart, skeletal muscles, and the brain, but not in the GI tract...
  98. ncbi Gastrointestinal hormonal dysfunction in gastroparesis and functional dyspepsia
    J Khoo
    Centre of Clinical Research Excellence in Nutritional Physiology, School of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, SA, Australia
    Neurogastroenterol Motil 22:1270-8. 2010
    ..sensory function, and appear to contribute to the pathogenesis of delayed gastric emptying associated with gastroparesis, functional dyspepsia (FD) and feed intolerance in critical illness...
  99. ncbi Chronic metoclopramide therapy for diabetic gastroparesis
    Paul F Lata
    Case Management Services, Bay Area Medical Center, Marinette, WI 54143 4242, USA
    Ann Pharmacother 37:122-6. 2003
    To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.
  100. ncbi Oral erythromycin and symptomatic relief of gastroparesis: a systematic review
    Kalyani Maganti
    Department of Internal Medicine, St Joseph s Hospital, Chicago, Illinois, USA
    Am J Gastroenterol 98:259-63. 2003
    ..in improving gastric emptying, little information exists concerning symptom improvement in patients with gastroparesis. The aim of this study was to review clinical trials of erythromycin to determine the efficacy of this agent ..
  101. pmc Treatment options for patients with severe gastroparesis
    Hasse Abrahamsson
    Department of Internal Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Gut 56:877-83. 2007

Research Grants63

  1. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2004
    In a new therapeutic approach for delayed gastric emptying and gastroparesis, Virginia Technologies, Inc...
  2. Effects of Acupuncture on Gastric Motility in Rats
    Toku Takahashi; Fiscal Year: 2004
    ..We will study whether acupuncture shortens the period of postoperative ileus in rats. This study would provide beneficial information for patients with gastroparesis and postoperative ileus.
  3. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    b>Gastroparesis is a disabilitating disease affecting predominantly young women. The biological basis of this disorder and its associated gender bias remains poorly understood...
  4. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..NO) has been implicated in a number of gastrointestinal motility disorders including achalasia, diabetic gastroparesis, pyloric stenosis, chronic constipation, and Hirschsprung's Disease...
  5. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..to nausea treatment in a large number of clinical situations, including cancer chemotherapy, diabetic gastroparesis, anorexia nervosa, ischemic gastropathy, chronic intestinal obstruction, abdominal malignancy, and functional ..
  6. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..Defective NO neurotransmission is also implicated in diabetic gastroparesis and functional disorders of the gut such as irritable bowel syndrome and spasm of biliary and pancreatic ..
  7. Interstitial Cells of Cajal in Diabetic Gastropathy
    TAMAS ORDOG; Fiscal Year: 2013
    ..The classic view of gastrointestinal motility disorders including diabetic gastroparesis is that they are due to impaired tissue function and degeneration of terminally differentiated cell types such ..
  8. Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signaling
    Wenhui Hu; Fiscal Year: 2013
    ..in adult ENS have been associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), gastroparesis and chronic constipation/diarrhea...
  9. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..of how Ednrb signaling alters gastrointestinal smooth muscle activity could lead to potential treatments for common disorders affecting 10-30% of the US population, such as reflux, constipaiton, and gastroparesis.
  10. Insulin effects in the vagal complex
    Camille Bond Blake; Fiscal Year: 2013
    ..of diabetes, significantly alters central vagal function and diabetics often experience gastric dysfunction, gastroparesis and other visceral symptomatology...
  11. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    ..unsuspected reactivation of VZV in enteric neurons might contribute to the pathogenesis of GI disorders such as irritable bowel syndrome, inflammatory bowel disease, idiopathic gastroparesis, and chronic intestinal pseudoobstruction.
  12. CORRELATION BETWEEN STRUCTURAL AND MOTOR DEFECTS IN DIABETIC GASTROPARESIS
    Grant Hennig; Fiscal Year: 2011
    ..b>Gastroparesis, or delayed gastic emptying, occurs in approximately one third of patients with Type 2 diabetes mellitus (T2DM)..
  13. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2012
    ..mechanotranscription may also be involved in other stretch-related motility disorders such as achalasia and gastroparesis, where lack of relaxation of lower esophageal sphincter and pylorus sphincter is associated with distension ..
  14. Smooth muscle plasticity: A COBRE
    Kenton M Sanders; Fiscal Year: 2013
    ..Project 1: Correlation between structural and motor defects in diabetic gastroparesis to be headed by Dr...
  15. Effects of hyperglycemia on gastric emptying
    Toku Takahashi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abstract Gastroparesis (delayed gastric emptying) occurs in the absence of mechanical obstruction. Although associated with many diseases, the most frequent cause of gastroparesis is diabetes...
  16. Gastroparesis Consortium Continuation and New Type 2 Diabetes Mellitus Studiies
    Kenneth L Koch; Fiscal Year: 2013
    ..Registry to continue to investigate the etiology, epidemiology, and morbidity and mortality associated with gastroparesis. Our center will support the Pathological Basis of Gastroparesis Study conducted by Dr...
  17. Advancing Science for the Diagnosis and Treatment of Gastroparesis
    Pankaj J Pasricha; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal ..
  18. International Conference on Nausea and Vomiting 2013
    Bill J Yates; Fiscal Year: 2013
    ..The conference will include five primary sessions: 1) Personalized Medicine and Genetics;2) Gastroparesis and Cyclic Vomiting Syndrome;3) Vestibular and Gastrointestinal Integration;4) Assessment and Control of ..
  19. Continuation of the NIDDK Gastroparesis Consortium
    Irene Sarosiek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gastroparesis (GP) is a disorder of gastric motilityfunction characterized by a delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness,..
  20. Zebrafish Based Model for Gastrointenstinal Physiology
    ADAM J RICH; Fiscal Year: 2010
    ..GI dysmotility affects many patients, for example, gastroparesis occurs in ~50% of diabetic patients and is associated with ICC deficits...
  21. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    b>Gastroparesis is a common disease defined as delayed emptying of the stomach...
  22. Temple University Gastroparesis Clinical Center
    HENRY PAUL PARKMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with gastroparesis often suffer with chronic gastrointestinal symptoms that are not adequately treated due to both a lack of understanding of the underlying pathophysiology and lack of ..
  23. Gastroparesis Clinical Research Consortium-University of Michigan Clinical Center
    William L Hasler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gastroparesis is characterized by delayed gastric emptying in association with nausea, vomiting, fullness, early satiety, and pain that has devastating impacts on quality of life...
  24. An Implantable Pacemaker Optimized for Smooth Muscle Stimulation
    ROBERT ARTHUR ROSS; Fiscal Year: 2012
    ..Specifically, electrical stimulation has been shown to be effective in the treatment of indications including gastroparesis and obesity and more recently, chronic constipation...
  25. Pathobiology of the Enteric System
    Joseph H Szurszewski; Fiscal Year: 2013
    ..Pathobiology of Diabetic Gastroenteropathy) studies the role of HO1 in preventing the development of diabetic gastroparesis and the mechanisms that regulate HOI activity in diabetes...
  26. MEHARRY RCMI PROGRAM IN WOMEN'S HEALTH RESEARCH
    Anna Cherrie Epps; Fiscal Year: 2013
    ..Dr. P. Gangula will continue his studies on diabetic gastroparesis, which has a 4-times greater incidence in women, and Dr. N...
  27. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    Clinical studies of human diabetic gastroparesis support the notion of autonomic neural dysfunction as a causative factor...
  28. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2000
    ..proposed commercial application: not available ..
  29. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    b>Gastroparesis is a common disease defined as the delayed emptying of the stomach...
  30. Gastroparesis Consortium Continuation-Data Coordinating Center
    Aynur Unalp-Arida; Fiscal Year: 2013
    ..This proposal from the Johns Hopkins University is to continue as the Data Coordinating Center (DCC) of the Gastroparesis Clinical Research Consortium (GPCRC) to support the clinical centers as they complete three treatment trials (..
  31. Continuation: UMMC's Clinical Center in NIDDK's Gastroparesis Research
    THOMAS LYMAN ABELL; Fiscal Year: 2013
    ..of Mississippi Medical Center proposes to continue its participation as a Clinical Center in NIDDK's Gastroparesis Clinical Research Consortium...
  32. BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS
    LEONARD A BRADSHAW; Fiscal Year: 2013
    ..We have shown that MGG propagation characteristics differ when comparing normal subjects with gastroparesis patients...
  33. Novel Evaluation & Treatment of Gastric Dysmotility
    HENRY PAUL PARKMAN; Fiscal Year: 2010
    Gastric dysmotility is relevant in several clinical disorders including gastroparesis and functional dyspepsia...
  34. NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERS
    Christopher Carreras; Fiscal Year: 2000
    ..for the treatment of gastrointestinal motility disorders such as gastroesophogeal reflux disease (GERD), gastroparesis, postoperative ileus, scleroderma, gallstones, and as a quick and effective drug to stimulate stomach emptying ..
  35. NON-INVASIVE BREATH TEST FOR MEASURING GASTRIC EMPTYING
    KEITH GOODMAN; Fiscal Year: 2000
    ..The test will be used to identify patients with gastroparesis (impaired gastric emptying) and monitor the effectiveness of their treatment...
  36. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..from the Applicant's Abstract): Impairment of gastric adaptive relaxation reflexes is an underlying cause of gastroparesis. It may also contribute to gastroesphageal reflux disease and metaplasia (Barretts)...
  37. Acquisition of a Hybrid LC/MS/MS to Enhance Research in Nevada
    David Quilici; Fiscal Year: 2009
    ..This research includes: 1) Smooth muscle physiology looking at diabetic gastroparesis, ulcerative colitis, Cardiac disease and Muscular Dystrophy 2) Neuronal growth and Neuron reproducibility 3) ..
  38. Treatment of diabetic gastroparesis with nitric oxide
    Robert Raulli; Fiscal Year: 2007
    ..will establish proof of concept for the use of nitric oxide (NO) as an effective treatment for diabetic gastroparesis. The NO will be delivered using Amulet's NORTECH nitric oxide releasing technology...
  39. ELECTRICAL STIMULATION FOR TREATMENT OF GASTROPARESIS
    Jiande Chen; Fiscal Year: 1999
    ..stimulation and to study the efficacy and efficiency of multi-channel electrical stimulation for the treatment gastroparesis in animal models...
  40. Treatment of Gastroparesis with Multi-Channel Pacing
    Zhiyue Lin; Fiscal Year: 2005
    ..and efficacy of multi-channel gastric electrical stimulation (MGS) in the treatment of patients with diabetic gastroparesis refractory to standard medical therapy...
  41. Synergism of prokinetics on human intestinal transit
    Amy Foxx Orenstein; Fiscal Year: 2006
    ..Thus, this work should lead to novel approaches to therapies for patients with motility disorders, such as gastroparesis, slow transit constipation and pseudoobstruction for which current therapy is suboptimal.
  42. Motilin Receptor Agonists for Diabetic Gastroperesis
    David Myles; Fiscal Year: 2005
    The overall goal of this Fast-Track application is to develop a therapeutic agent for the treatment of diabetic gastroparesis that can be used effectively several times a day with meals to avoid the discomfort associated with slow ..
  43. Combinatorial Macrolide GPCR Screening Library
    Brian Metcalf; Fiscal Year: 2001
    ..Agonists of the Motilin receptor could be used in the attachment of gastroesophageal reflux disease and gastroparesis. Both diseases have significant markets, and development of suitable treatments would have substantial ..
  44. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  45. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  46. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  47. TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITIS
    PANKAJ PASRICHA; Fiscal Year: 2004
    ..These studies will provide insight into the underlying mechanism of pancreatic pain that may eventually lead to new and more effective forms of therapy. ..
  48. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  49. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2004
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  50. INTESTINAL SECRETION & INFLAMMATION - IMPACT OF AMMONIA
    Jeffrey Matthews; Fiscal Year: 2004
    ..These studies highlight the importance of basolateral K+ channels in the regulation of secretion and other epithelial functions and reinforce their potential as targets for new drug design. ..
  51. 12th Biennial Meeting of the American Motility Society
    Jiande Chen; Fiscal Year: 2002
    ..Other factors such as financial hardship and minority issues will also be considered. We plan to issue 15 Young Investigator Awards and 10 Travel Awards. ..
  52. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2009
    ..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
  53. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2008
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  54. SALT TRANSPORT IN SURGICAL DIARRHEAL DISEASE
    Jeffrey Matthews; Fiscal Year: 2008
    ..abstract_text> ..
  55. Neurogastric electrical stimulation for treating chemotherapy-induced emesis
    Jiande Chen; Fiscal Year: 2008
    ..nGES) has recently been proposed and found effective in treating nausea and vomiting in patients with gastroparesis. Its central and neuronal mechanisms have recently been elucidated...
  56. Ethanol on Overnight Glucose Regulation in Diabetes
    Mark Burge; Fiscal Year: 2008
    ..These important studies will provide a scientific basis for the prevention of overnight hypoglycemia (and the attendant cost savings) by providing mechanistic insights into the causes of nocturnal hypoglycemia. [unreadable] [unreadable]..
  57. Dual Pulse Electrical Stimulation for Gastroparesis
    Jiande Chen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Gastroparesis is defined as delayed emptying of solids and is a common disease defined as delayed emptying of the stomach...
  58. Intestinal Pacing for Intestinal Pseudo-Obstruction
    Jiande Chen; Fiscal Year: 2007
    ..Feasibility of such a novel method will be tested in this Phase I project. [unreadable] [unreadable] [unreadable]..
  59. Clinical and Translational Science Center at the University of New Mexico
    Mark Burge; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Experimental approaches to understanding the ENS and its disorders
    James Galligan; Fiscal Year: 2006
    ..This will help the attendees develop a network of professional contacts who can help the young investigator in the career development process. [unreadable] [unreadable]..
  61. THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITY
    Jiande Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. Quantitative Approach to Analysis of Cortical Dynamics
    Hualou Liang; Fiscal Year: 2005
    ..abstract_text> ..