gastroparesis

Summary

Summary: Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

Top Publications

  1. pmc Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years
    Purna Kashyap
    Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Gut 59:1716-26. 2010
  2. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010
  3. doi Gastric electrical stimulation improves outcomes of patients with gastroparesis for up to 10 years
    Richard W McCallum
    Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Clin Gastroenterol Hepatol 9:314-319.e1. 2011
  4. doi Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study
    Richard W McCallum
    University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Gastroenterol Hepatol 8:947-54; quiz e116. 2010
  5. ncbi Temporary gastric electrical stimulation with orally or PEG-placed electrodes in patients with drug refractory gastroparesis
    Srinivasa Ayinala
    Division of Digestive Diseases, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Gastrointest Endosc 61:455-61. 2005
  6. pmc Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis
    Kyoung Moo Choi
    Enteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 135:2055-64, 2064.e1-2. 2008
  7. ncbi Treatment of gastroparesis: a multidisciplinary clinical review
    T L Abell
    University of Mississippi Medical Center, Jackson, USA
    Neurogastroenterol Motil 18:263-83. 2006
  8. doi Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre
    T Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Br J Surg 97:1043-50. 2010
  9. doi A novel classification scheme for gastroparesis based on predominant-symptom presentation
    Steven P Harrell
    Division of Gastroenterology Hepatology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Clin Gastroenterol 42:455-9. 2008
  10. ncbi Functional dyspepsia: mechanisms of symptom generation and appropriate management of patients
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street, SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 36:649-64, xi-x. 2007

Detail Information

Publications226 found, 100 shown here

  1. pmc Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years
    Purna Kashyap
    Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Gut 59:1716-26. 2010
    Diabetic gastroparesis is a disorder that occurs in both type 1 and type 2 diabetes. It is associated with considerable morbidity among these patients and with the resultant economic burden on the health system...
  2. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010
    Despite the relatively high prevalence of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood...
  3. doi Gastric electrical stimulation improves outcomes of patients with gastroparesis for up to 10 years
    Richard W McCallum
    Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Clin Gastroenterol Hepatol 9:314-319.e1. 2011
    We assessed the long-term clinical outcomes of gastric electrical stimulation (GES) therapy with Enterra (Enterra Therapy System; Medtronic, Minneapolis, MN) in a large cohort of patients with severe gastroparesis.
  4. doi Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study
    Richard W McCallum
    University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Gastroenterol Hepatol 8:947-54; quiz e116. 2010
    Gastric electrical stimulation (GES) treats refractory gastroparesis by delivering electric current, via electrodes, to gastric smooth muscle...
  5. ncbi Temporary gastric electrical stimulation with orally or PEG-placed electrodes in patients with drug refractory gastroparesis
    Srinivasa Ayinala
    Division of Digestive Diseases, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Gastrointest Endosc 61:455-61. 2005
    Gastric electrical stimulation (GES) has been shown to be efficacious for drug refractory gastroparesis, but GES requires surgery...
  6. pmc Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis
    Kyoung Moo Choi
    Enteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 135:2055-64, 2064.e1-2. 2008
    Diabetic gastroparesis (delayed gastric emptying) is a well-recognized complication of diabetes that causes considerable morbidity and makes glucose control difficult...
  7. ncbi Treatment of gastroparesis: a multidisciplinary clinical review
    T L Abell
    University of Mississippi Medical Center, Jackson, USA
    Neurogastroenterol Motil 18:263-83. 2006
    This clinical review on the treatment of patients with gastroparesis is a consensus document developed by the American Motility Society Task Force on Gastroparesis...
  8. doi Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre
    T Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Br J Surg 97:1043-50. 2010
    ..Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy. The International Study Group of Pancreatic Surgery (ISGPS) definition of DGE has not been evaluated and validated in a high-volume centre...
  9. doi A novel classification scheme for gastroparesis based on predominant-symptom presentation
    Steven P Harrell
    Division of Gastroenterology Hepatology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Clin Gastroenterol 42:455-9. 2008
    Symptoms of gastroparesis are very diverse. Classifying patients by predominant symptom may improve management strategy.
  10. ncbi Functional dyspepsia: mechanisms of symptom generation and appropriate management of patients
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street, SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 36:649-64, xi-x. 2007
    ..To achieve greater therapeutic efficacy, it may be necessary to target the therapeutic approach to a specific pathophysiology, such as impaired gastric emptying...
  11. pmc Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
    Henry P Parkman
    Gastroenterology Section, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 140:101-15. 2011
    Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity...
  12. pmc Cellular changes in diabetic and idiopathic gastroparesis
    Madhusudan Grover
    Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 140:1575-85.e8. 2011
    Cellular changes associated with diabetic and idiopathic gastroparesis are not well described...
  13. doi Treatment of high-frequency gastric electrical stimulation for gastroparesis
    Huikuan Chu
    Division of Gastroenterology, Department of Internal Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Gastroenterol Hepatol 27:1017-26. 2012
    The aim of this study was to assess the effects of gastric electrical stimulation (GES) on symptoms and gastric emptying in patients with gastroparesis, and the effects of GES on the three subgroups of gastroparesis.
  14. pmc Epidemiology, mechanisms, and management of diabetic gastroparesis
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN, USA
    Clin Gastroenterol Hepatol 9:5-12; quiz e7. 2011
    Recent evidence of the significant impact of gastroparesis on morbidity and mortality mandates optimized management of this condition...
  15. pmc Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping
    Gregory O'Grady
    Department of Surgery, University of Auckland, Auckland, New Zealand
    Gastroenterology 143:589-98.e1-3. 2012
    ..Disrupted ICC networks and gastric dysrhythmias are each associated with gastroparesis. However, there are no data on the initiation and propagation of slow waves in gastroparesis because research ..
  16. doi Pathophysiology and management of gastroparesis
    Joan Khoo
    Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia
    Expert Rev Gastroenterol Hepatol 3:167-81. 2009
    b>Gastroparesis is characterized by upper gastrointestinal symptoms associated with delayed gastric emptying, without mechanical obstruction. However, symptoms do not correlate well with the magnitude of delay in gastric emptying...
  17. ncbi Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up
    Thomas Abell
    Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    JPEN J Parenter Enteral Nutr 27:277-81. 2003
    ..depletion, either macronutrient- or micronutrient-related, is common in patients with drug-refractory gastroparesis (GP) for which there is often no effective treatment...
  18. pmc Carbon monoxide reverses diabetic gastroparesis in NOD mice
    Purna C Kashyap
    Mayo Clinic, 200 First St SW, Rochester MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 298:G1013-9. 2010
    Diabetic gastroparesis is associated with increased oxidative stress attributable to loss of upregulation of heme oxygenase-1 (HO1), with resultant damage to interstitial cells of Cajal and delayed gastric emptying...
  19. doi Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipation
    Braden Kuo
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Dig Dis Sci 56:2928-38. 2011
    The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.
  20. ncbi Advances in diabetic gastroparesis
    Michael Camilleri
    Gastroenterology Research Unit, Mayo Foundation, Rochester, MN, USA
    Rev Gastroenterol Disord 2:47-56. 2002
    This review addresses the advances in our understanding of the epidemiology and mechanisms in diabetic gastroparesis and dyspepsia...
  21. ncbi Malignant gastroparesis: pathogenesis and management of an underrecognized disorder
    Kavitha R Donthireddy
    Department of Medicine and Surgery, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Support Oncol 5:355-63. 2007
    b>Gastroparesis is a disorder of the stomach caused by delayed gastric emptying in the absence of mechanical obstruction. Symptoms of gastroparesis include nausea, vomiting, early satiety, bloating, and abdominal discomfort...
  22. pmc Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans
    M Grover
    Mayo Clinic, Rochester, MN, USA
    Neurogastroenterol Motil 24:844-52. 2012
    ..The aims of this study were to determine the morphology and distribution of PDGFRα-immunoreactive (ir) FLC in human gastric muscle and to determine if FLC are altered in gastroparesis, where ICC are reduced.
  23. doi Gastric electrical stimulation is an effective and safe treatment for medically refractory gastroparesis
    Daniel McKenna
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Surgery 144:566-72; discussion 572-4. 2008
    b>Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain...
  24. ncbi A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit
    Weidong Xie
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Eur J Pharmacol 510:113-20. 2005
    ..transit was thought to be a new tactic to treat postprandial hypertriglyceridemia in diabetic individuals with gastroparesis. Diabetic gastroparesis, lipid load testing, and the effect of domperidone or aqueous extract of rhizomes of ..
  25. ncbi Development and validation of a patient-assessed gastroparesis symptom severity measure: the Gastroparesis Cardinal Symptom Index
    D A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, MD 20814, USA
    Aliment Pharmacol Ther 18:141-50. 2003
    Patient-based symptom assessments are necessary to evaluate the effectiveness of medical treatments for gastroparesis.
  26. ncbi Treatment of diabetic gastroparesis by high-frequency gastric electrical stimulation
    Zhiyue Lin
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Diabetes Care 27:1071-6. 2004
    To investigate the long-term efficacy of high-frequency gastric electrical stimulation (GES) for treating diabetic gastroparesis.
  27. ncbi Gastric electrical stimulation for medically refractory gastroparesis
    Thomas Abell
    University of Mississippi, Jackson, Mississippi, USA
    Gastroenterology 125:421-8. 2003
    This study investigated the efficacy of gastric electrical stimulation for the treatment of symptomatic gastroparesis unresponsive to standard medical therapy.
  28. pmc CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice
    Kyoung Moo Choi
    Enteric Neuroscience Program and Department of Physiology, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 138:2399-409, 2409.e1. 2010
    b>Gastroparesis is a well-recognized complication of diabetes. In diabetics, up-regulation of heme oxygenase-1 (HO1) in gastric macrophages protects against oxidative stress-induced damage...
  29. ncbi Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995-2004
    Yize R Wang
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Gastroenterol 103:313-22. 2008
    b>Gastroparesis is an increasingly recognized disorder. Its prevalence in the United States is unknown. We examined the trends, characteristics, and outcomes of gastroparesis-related hospitalizations during 1995-2004.
  30. ncbi Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study
    R W McCallum
    Center for GI Nerve and Muscle Function, University of Kansas Medical Center, Kansas City, KS, USA
    Aliment Pharmacol Ther 26:1121-30. 2007
    ..Mitemcinal is an orally active motilin agonist that could potentially improve gastric emptying...
  31. ncbi Gastroparesis: symptoms, evaluation, and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, University of Michigan Hospital, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 36:619-47, ix. 2007
    b>Gastroparesis presents with gastrointestinal symptoms and nongastrointestinal manifestations in association with objective delays in gastric emptying. The condition may complicate several systemic disorders or may be idiopathic in nature...
  32. ncbi Clinical response to gastric electrical stimulation in patients with postsurgical gastroparesis
    Richard McCallum
    Department of Medicine, Mail Stop 1058, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Clin Gastroenterol Hepatol 3:49-54. 2005
    The aim of this study was to report the long-term clinical response to high-frequency gastric electrical stimulation (GES) in 16 patients with postsurgical gastroparesis who failed standard medical therapy.
  33. pmc Predictive factors for clinical improvement with Enterra gastric electric stimulation treatment for refractory gastroparesis
    Jennifer L Maranki
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, Philadelphia, PA 19140, USA
    Dig Dis Sci 53:2072-8. 2008
    The objectives of this study were to determine the clinical response to Enterra gastric electric stimulation (GES) in patients with refractory gastroparesis and to determine factors associated with a favorable response.
  34. ncbi Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study
    C S Chang
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan
    Digestion 64:184-90. 2001
    Abnormal gastric slow-wave frequencies have been observed in diabetic gastroparesis and are associated with impaired antral motor activity...
  35. ncbi Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis
    Z Lin
    Department of Medicine, University of Kansas Medical Center, Kansas City, 66160, USA
    Neurogastroenterol Motil 18:18-27. 2006
    ..5 to 7.9% at 3 years. We conclude that a significant improvement in symptoms and all measures of clinical outcome can be maintained for greater than 3 years with GES in patients with refractory gastroparesis.
  36. ncbi Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment
    Sung Wan Kim
    Department of Psychiatry, Chonnam National Univ Hospital, 8 Hak Dong, Dong Ku, Kwangju 501 757, Republic of Korea
    Psychosomatics 47:440-2. 2006
    b>Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction...
  37. pmc Altered expression of Ano1 variants in human diabetic gastroparesis
    Amelia Mazzone
    Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 286:13393-403. 2011
    ..gastrointestinal pacemaker cells, underlie a number of gastrointestinal motility disorders, including diabetic gastroparesis. In the muscle layers, ICC selectively express Ano1, thought to underlie classical Ca(2+)-activated Cl(-) ..
  38. pmc Two-channel gastric pacing in patients with diabetic gastroparesis
    Zhiyue Lin
    University of Kansas Medical Center, Kansas City, KS, USA
    Neurogastroenterol Motil 23:912-e396. 2011
    ..were to investigate the effects of two-channel gastric pacing on gastric myoelectrical activity, and energy consumption with the secondary intent to monitor gastric emptying and symptoms in patients with severe diabetic gastroparesis.
  39. doi Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer
    M Nguyen-Tat
    Department of Internal Medicine II, HSK Wiesbaden, Wiesbaden, Germany
    Z Gastroenterol 46:274-8. 2008
    b>Gastroparesis is a common but challenging disorder which can be idiopathic or induced by a variety of underlying diseases, most frequently by diabetes, or post-surgical conditions of the upper abdomen...
  40. doi Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis: literature review and our experience
    John Leung
    Gastroenterology, Internal Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Dig Dis Sci 54:401-5. 2009
    ..This condition is well described in the literature and is thought to result from pancreatic cancer-associated gastroparesis (PCAG). No clinical guideline is available for diagnosing and managing this rare disease.
  41. doi [New therapeutic approaches to diabetic gastroparesis]
    Michael Hummel
    Klinik fur Endokrinologie, Diabetologie und Suchtmedizin, Klinikum Schwabing, Städt Klinikum München GmbH and Institut für Diabetesforschung, Munchen
    Med Klin (Munich) 103:514-8. 2008
    ..PHYSICAL EXAMINATION: A 24-year-old man with type 1 diabetes, nonresponding to standard treatment for severe gastroparesis, was admitted to hospital due to persisting nausea and vomiting...
  42. doi Impact of anastomotic complications on outcome after laparoscopic gastrectomy for early gastric cancer
    Y Nagasako
    Department of Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Br J Surg 99:849-54. 2012
    ..The aims of this observational study were to identify potential factors that predict anastomotic complications and investigate the impact of anastomotic complications in patients undergoing gastrectomy for early gastric cancer...
  43. ncbi [Diabetic gastroparesis]
    M P Stassen
    Clinique A Renard, Herstal
    Rev Med Liege 60:509-15. 2005
    Diabetic gastroparesis corresponds to symptomatic as well as asymptomatic gastric retention without organic abnormality of stomach, pylorus or gut...
  44. ncbi Severe gastroparesis: new treatment alternatives
    Hasse Abrahamsson
    Department of Internal Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Best Pract Res Clin Gastroenterol 21:645-55. 2007
    ..and the motilin receptor agonist erythromycin have been the cornerstones in drug treatment of severe gastroparesis for more than a decade. No new drugs have been approved for treatment of this disorder in this period...
  45. doi The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology
    I Sarosiek
    Center for Gastrointestinal Nerve and Muscle Function and GI Motility, University of Kansas Medical Center, Kansas City, USA
    Aliment Pharmacol Ther 31:313-22. 2010
    ..Wireless pH and pressure motility capsule (wireless motility capsule) technology provides a method to assess regional gastrointestinal transit times...
  46. doi Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data
    J M Wo
    Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, USA
    Aliment Pharmacol Ther 33:679-88. 2011
    Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake...
  47. pmc Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population
    Rok Seon Choung
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:82-8. 2012
    In patients with diabetes mellitus (DM) and upper gastrointestinal symptoms, a diagnosis of diabetic gastroparesis is often considered, but population-based data on the epidemiology of diabetic gastroparesis are lacking...
  48. doi Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects
    Henry P Parkman
    Gastroenterology Section, School of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:115-24. 2011
    Domperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability...
  49. doi Video: temporary gastric electrical stimulation for gastroparesis: endoscopic placement of electrodes (ENDOstim)
    Sumanth R Daram
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Surg Endosc 25:3444-5. 2011
    ..electrical stimulation (GES) to be an effective management strategy for patients with medication refractory gastroparesis. However, placement of a permanent GES device requires surgery and has considerable cost considerations...
  50. doi Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis
    B Braden
    Medical Department I, Hospital of the J W Goethe University, Frankfurt, Germany
    Neurogastroenterol Motil 21:632-8, e25. 2009
    ..study addressed the question of whether STW 5 accelerates gastric emptying in patients with FD and gastroparesis. One-hundred and three patients diagnosed with FD were randomly assigned to a treatment with either STW 5 or a ..
  51. pmc Ultrastructural differences between diabetic and idiopathic gastroparesis
    Maria Simonetta Faussone-Pellegrini
    University of Florence, Florence, Italy
    J Cell Mol Med 16:1573-81. 2012
    The ultrastructural changes in diabetic and idiopathic gastroparesis are not well studied and it is not known whether there are different defects in the two disorders...
  52. pmc Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium
    M Grover
    Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:531-9, e249. 2012
    Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium...
  53. ncbi Autonomic dysfunction and gastroparesis in cirrhosis
    G Nicholas Verne
    Divisions of Gastroenterology, Hepatology, and Nutrition, University of Florida, Malcom Randall VAMC, 1601 SW Archer Road, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:72-6. 2004
    ..The cause of these motility disorders in cirrhotics is unknown, however, underlying autonomic dysfunction may play a role...
  54. pmc Gastroparesis in patients with inactive Crohn's disease: a case series
    Jón O Kristinsson
    Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands
    BMC Gastroenterol 7:11. 2007
    ..The aim of this case series was to evaluate clinical characteristics of 5 patients with inflammatory bowel disease and symptoms and signs of upper gut dysmotility...
  55. ncbi Further experience with gastric stimulation to treat drug refractory gastroparesis
    Jameson Forster
    Department of Surgery, Kansas University Medical Center, Kansas City 66160 7309, USA
    Am J Surg 186:690-5. 2003
    Gastric electrical stimulation (GES) has been introduced for patients with gastroparesis refractory to pharmacological therapy.
  56. doi Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis
    Brian Hyett
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Gastroenterology 137:445-52. 2009
    The aim of this study was to evaluate the prognostic value of gastric emptying studies on the morbidity associated with diabetic gastroparesis.
  57. doi Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
    N Ejskjaer
    Aarhus University, Aarhus, Denmark
    Neurogastroenterol Motil 22:1069-e281. 2010
    b>Gastroparesis, a chronic disorder of abnormal gastric motility, is common in patients with diabetes mellitus. A synthetic, selective ghrelin receptor agonist, TZP-101, is in clinical development for treatment of gastroparesis...
  58. ncbi Pilot study on gastric electrical stimulation on surgery-associated gastroparesis: long-term outcome
    Benton Oubre
    University of Mississippi Medical Center, Jackson, MS, USA
    South Med J 98:693-7. 2005
    Patients with postgastric surgery gastroparesis are often unresponsive to conventional medical therapy...
  59. pmc Gastroparesis: current diagnostic challenges and management considerations
    Shamaila Waseem
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610, USA
    World J Gastroenterol 15:25-37. 2009
    b>Gastroparesis refers to abnormal gastric motility characterized by delayed gastric emptying in the absence of mechanical obstruction. The most common etiologies include diabetes, post-surgical and idiopathic...
  60. ncbi Gastric electrical stimulation with parameters for gastroparesis enhances gastric accommodation and alleviates distention-induced symptoms in dogs
    J H Xing
    Veterans Research Foundation, Oklahoma City, Oklahoma, USA
    Dig Dis Sci 51:2160-4. 2006
    Gastric electrical stimulation (GES) improves symptoms in patients with gastroparesis. We sought to determine if stimulation at fundus with parameters used for gastroparesis could affect gastric accommodation and distention-induced ..
  61. doi Small case series of gastric stimulation for the management of transplant-induced gastroparesis
    Lori A Filichia
    Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida 32610 0286, USA
    J Surg Res 148:90-3. 2008
    b>Gastroparesis is a recognized complication following organ transplantation with incidences reported between 24 and 83%...
  62. ncbi Refractory gastroparesis after Roux-en-Y gastric bypass: surgical treatment with implantable pacemaker
    J R Salameh
    Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA
    J Gastrointest Surg 11:1669-72. 2007
    b>Gastroparesis is a rare complication of Roux-en-Y gastric bypass. We evaluate the role of gastric electrical stimulation in medically refractory gastroparesis.
  63. ncbi Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis
    David N Moskovitz
    Department of Medicine, University of Toronto and University Health Network and Mount Sinai Hospital, Toronto, Canada
    Can J Gastroenterol 16:171-4. 2002
    ..A case of SCLC with positive anti-Hu antibodies presenting with intestinal pseudo-obstruction is presented. Gastrointestinal dysmotility as a manifestation of paraneoplastic syndrome is reviewed...
  64. ncbi Malignant gastroparesis: diagnostics and therapeutics
    Satish Nagula
    Gastroenterology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Support Oncol 5:366-7. 2007
  65. ncbi Domperidone is more effective than cisapride in children with diabetic gastroparesis
    A Franzese
    Department of Paediatrics, University of Naples Federico II, Naples, Italy
    Aliment Pharmacol Ther 16:951-7. 2002
    ..Disorders of gastrointestinal motility are commonly detected in patients with insulin-dependent diabetes mellitus and are associated with significant morbidity. They contribute to poor metabolic control of diabetes...
  66. ncbi Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis
    Kishore V Gaddipati
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Dig Dis Sci 51:1339-46. 2006
    Vagal nerve dysfunction has been implicated in the pathogenesis of diabetic gastroparesis, but its role in idiopathic gastroparesis remains uncertain...
  67. ncbi Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis
    Matthew Q Bromer
    Section of Gastroenterology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Gastrointest Endosc 61:833-9. 2005
    Botulinum toxin A injected into the pyloric sphincter has been reported in small case series to treat gastroparesis. This study reviews the use of this treatment in a large number of patients with gastroparesis.
  68. doi Small particle size of a solid meal increases gastric emptying and late postprandial glycaemic response in diabetic subjects with gastroparesis
    Eva A Olausson
    Diabetic Centre, Institute of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Diabetes Res Clin Pract 80:231-7. 2008
    ..emptying rate and lessens the fall in postprandial blood glucose in seven subjects with Type 1 diabetes and gastroparesis. Two solid meals of identical composition but of different particle size, with 5MBq (99m)Tc added to the meals,..
  69. ncbi No ghrelin response to oral glucose in diabetes mellitus with gastroparesis
    Shiko Asai
    Department of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine, Kawasaki, Japan
    Endocr J 56:79-87. 2009
    ..investigate the role of ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (..
  70. pmc Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis
    Pankaj J Pasricha
    Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Gastroenterol 8:21. 2008
    The pathophysiological basis of diabetic gastroparesis is poorly understood, in large part due to the almost complete lack of data on neuropathological and molecular changes in the stomachs of patients...
  71. ncbi Gastric electrical stimulation: an alternative surgical therapy for patients with gastroparesis
    Rodney J Mason
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Arch Surg 140:841-6; discussion 847-8. 2005
    Gastric electrical stimulation is an alternative to gastrectomy in patients with refractory gastroparesis.
  72. ncbi Gastric electrical stimulation has an immediate antiemetic effect in patients with gastroparesis
    Babajide O Familoni
    Department of Electrical Engineering, The University of Memphis, TN 38152, USA
    IEEE Trans Biomed Eng 53:1038-46. 2006
    ..Electrical stimulation has been successfully employed to treat diseases involving electro-pathology in the heart, skeletal muscles, and the brain, but not in the GI tract...
  73. ncbi Electrical stimulation for gastroparesis. Gastric motility restored
    J de Csepel
    Department of Surgery, St Vincent s Hospital, 170 West 12 Street, New York, NY 10011, USA
    Surg Endosc 20:302-6. 2006
    b>Gastroparesis is a disabling, and sometimes fatal, disease that often does not respond to medical treatment...
  74. ncbi Chronic metoclopramide therapy for diabetic gastroparesis
    Paul F Lata
    Case Management Services, Bay Area Medical Center, Marinette, WI 54143 4242, USA
    Ann Pharmacother 37:122-6. 2003
    To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.
  75. ncbi Implantable gastric electrical stimulation: ready for prime time?
    Jieyun Yin
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas
    Gastroenterology 134:665-7. 2008
  76. doi Gastroparesis: pathogenesis, diagnosis and management
    William L Hasler
    Division of Gastroenterology, University of Michigan Hospital, 3912 Taubman Center, Ann Arbor, MI 5362, USA
    Nat Rev Gastroenterol Hepatol 8:438-53. 2011
    b>Gastroparesis is a prevalent condition that produces symptoms of delayed gastric emptying in the absence of physical blockage...
  77. ncbi The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Diabetes Care 27:2341-7. 2004
    b>Gastroparesis is a disorder of delayed gastric emptying that is often chronic in nature. Up to 50% of type 1 diabetic subjects have symptoms of gastroparesis, which include nausea, vomiting, and early satiety...
  78. ncbi Clinical observation on acupuncture treatment in 35 cases of diabetic gastroparesis
    Ling Wang
    Department of Acupuncture and Moxibustion, Shenzhen Municipal Hospital of Traditional Chinese Medicine, Guangdong Province 518000
    J Tradit Chin Med 24:163-5. 2004
    In order to observe the therapeutic effects of acupuncture on diabetic gastroparesis, 80 cases were divided randomly into 3 groups...
  79. doi Review article: The diagnosis and management of gastroparesis
    J J L Haans
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Aliment Pharmacol Ther 26:37-46. 2007
    b>Gastroparesis is a disorder characterized by a delay in gastric emptying of a meal in the absence of a mechanical gastric outlet obstruction.
  80. doi Central neuronal mechanisms of gastric electrical stimulation in diabetic gastroparesis
    Jens B Frøkjaer
    Center for Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark
    Scand J Gastroenterol 43:1066-75. 2008
    ..Modulation of the central nervous system excitability may be involved. The objective of the study was to investigate the central effects of GES, including the possible modulation of the visceral sensory nervous system...
  81. doi Gastrointestinal hormonal dysfunction in gastroparesis and functional dyspepsia
    J Khoo
    Centre of Clinical Research Excellence in Nutritional Physiology, School of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, SA, Australia
    Neurogastroenterol Motil 22:1270-8. 2010
    ..sensory function, and appear to contribute to the pathogenesis of delayed gastric emptying associated with gastroparesis, functional dyspepsia (FD) and feed intolerance in critical illness...
  82. pmc Treatment options for patients with severe gastroparesis
    Hasse Abrahamsson
    Department of Internal Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Gut 56:877-83. 2007
  83. doi Symptoms of gastroparesis: use of the gastroparesis cardinal symptom index in symptomatic patients referred for gastric emptying scintigraphy
    Daniel W Cassilly
    Gastrointestinal Section, Department of Medicine, Temple University, Philadelphia, PA 19140, USA
    Digestion 78:144-51. 2008
    The Gastroparesis Cardinal Symptom Index (GCSI) was developed to assess symptoms of gastroparesis...
  84. ncbi Oral erythromycin and symptomatic relief of gastroparesis: a systematic review
    Kalyani Maganti
    Department of Internal Medicine, St Joseph s Hospital, Chicago, Illinois, USA
    Am J Gastroenterol 98:259-63. 2003
    ..in improving gastric emptying, little information exists concerning symptom improvement in patients with gastroparesis. The aim of this study was to review clinical trials of erythromycin to determine the efficacy of this agent ..
  85. ncbi Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide
    P Jay Pasricha
    Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Nat Clin Pract Gastroenterol Hepatol 3:138-48. 2006
    Metoclopramide, the only drug approved by the FDA for treatment of diabetic gastroparesis, but used off-label for a variety of other gastrointestinal indications, has many potentially troublesome adverse neurologic effects, particularly ..
  86. ncbi Ghrelin gastrokinetic action in patients with neurogenic gastroparesis
    M Binn
    Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Peptides 27:1603-6. 2006
    ..We aimed to verify the gastrokinetic capacity of ghrelin in human. Patients with gastroparesis attributed to a neural dysregulation by diabetes (n = 5) or surgical vagotomy (n = 1) were evaluated...
  87. ncbi Gastric electrical stimulation for the treatment of gastroparesis: ready for prime time?
    D Ang
    Digestion 75:80-2. 2007
  88. ncbi Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studies
    Harsha Vittal
    Maine Medical Center, University of Texas Medical Branch, Galveston, TX 77555 0764, USA
    Nat Clin Pract Gastroenterol Hepatol 4:336-46. 2007
    The pathogenesis of gastroparesis is complicated and poorly understood. This lack of understanding remains a major impediment to the development of effective therapies for this condition...
  89. ncbi Gastric electrical stimulation is safe and effective: a long-term study in patients with drug-refractory gastroparesis in three regional centers
    Curuchi Anand
    University of Arkansas for Medical Sciences, Little Rock, Ark, USA
    Digestion 75:83-9. 2007
    Drug-refractory gastroparesis has previously been without acceptable alternative therapies. Although gastric electrical stimulation has been used for over a decade, no long-term multicenter data exist.
  90. ncbi Diabetic gastroparesis
    Robert J Heine
    N Engl J Med 357:418; author reply 419-20. 2007
  91. doi Azithromycin in an older woman with diabetic gastroparesis
    Loredana Sutera
    Geriatric Unit, Post Graduate School of Geriatrics, University of Palermo, Italy
    Am J Ther 15:85-8. 2008
    ..is a challenging chronic complication of long-standing diabetes manifested with hypotension, syncope, gastroparesis, diarrhea, constipation, bladder dysfunction, sexual dysfunction, cardiac arrest, and/or sudden death...
  92. ncbi Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis
    J Arts
    Department of Neurogastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 26:1251-8. 2007
    Uncontrolled studies suggest benefit of intrapyloric injection of botulinum toxin (botox) for the treatment of gastroparesis, but controlled data are lacking.
  93. ncbi Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus
    J Faraj
    Gastroenterology Division, Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    Diabet Med 24:1235-9. 2007
    b>Gastroparesis is a common gastrointestinal complication in diabetes mellitus, whereas dysfunction in the other gastrointestinal organs has been less thoroughly investigated...
  94. doi Pyloric injection of botulinum toxin for the treatment of refractory GERD accompanied with gastroparesis: a preliminary report
    Seyed Amir Mirbagheri
    Amir Alam Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Dig Dis Sci 53:2621-6. 2008
    ..reflux disease (GERD) refractory to conventional medical treatment is frequently associated with gastroparesis, a complex condition with no definitive treatment to date...
  95. ncbi Gastroparesis with multiple sclerosis
    S Raghav
    Department of Neurology, Monash Medical Centre, Clayton, Victoria, Australia
    Mult Scler 12:243-4. 2006
    ..Upper gastrointestinal tract symptoms are rarely reported. We recently saw a patient with MS who had disabling gastroparesis and dysphagia.
  96. ncbi A systematic review of surgical therapy for gastroparesis
    Michael P Jones
    Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, and Department of Internal Medicine, St Joseph s Hospital, Chicago, Illinois, USA
    Am J Gastroenterol 98:2122-9. 2003
    b>Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain...
  97. pmc Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia
    Julia Borg
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Lund, Sweden
    BMC Gastroenterol 9:17. 2009
    ..The aim of this study was to examine if concentrations of oxytocin, cholecystokinin (CCK), gastrin and vasopressin in plasma differ between diabetics with normal function and dysfunction in GI motility...
  98. ncbi Relationship between the effects of cisapride on gastric emptying and plasma glucose concentrations in diabetic gastroparesis
    Michael Horowitz
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia
    Digestion 65:41-6. 2002
    ..The aim of this study was to determine in patients with diabetic gastroparesis whether the effect of cisapride on gastric emptying of solids and liquids is influenced by the plasma glucose ..
  99. ncbi Gastric pacing for severe gastroparesis in a heart-lung transplant recipient
    Anna Yiannopoulos
    Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California 94305 5407, USA
    J Heart Lung Transplant 23:371-4. 2004
    b>Gastroparesis is a serious complication of lung and heart-lung transplantation that can lead to malnutrition, gastroesophageal reflux, aspiration pneumonia and deteriorating lung function...
  100. doi Diabetic gastroparesis: diagnosis and management
    Jing Ma
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Drugs 69:971-86. 2009
    ..Scintigraphy represents the gold standard for measuring gastric emptying. The management of diabetic gastroparesis is less than optimal, partly because the pathogenesis has not been clearly defined...
  101. ncbi Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis
    Hiroshi Okamoto
    Department of Internal Medicine, Kochi Red Cross Hospital, Kochi
    Intern Med 42:655-64. 2003
    Diabetic patients with severe autonomic nervous disorder show delayed gastric emptying accompanied by diabetic gastroparesis, which decreases the electric activity of the stomach associated with gastric motility...

Research Grants77

  1. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2004
    In a new therapeutic approach for delayed gastric emptying and gastroparesis, Virginia Technologies, Inc...
  2. Effects of Acupuncture on Gastric Motility in Rats
    Toku Takahashi; Fiscal Year: 2004
    ..We will study whether acupuncture shortens the period of postoperative ileus in rats. This study would provide beneficial information for patients with gastroparesis and postoperative ileus.
  3. Gastric dysreflexia after spinal cord injury
    Gregory Holmes; Fiscal Year: 2007
    ..medulla is disrupted, resulting in an excitation of well documented medullary circuits that produce a spastic gastroparesis similar to truncal vagotomy...
  4. Temple University Gastroparesis Clinical Center
    Henry Parkman; Fiscal Year: 2007
    Patients with gastroparesis often suffer with chronic gastrointestinal symptoms that are not adequately treated due, in part, to a lack of understanding of the underlying pathophysiology and due, in part, to a lack of effective ..
  5. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2010
    ..Defective NO neurotransmission is also implicated in diabetic gastroparesis and functional disorders of the gut such as irritable bowel syndrome and spasm of biliary and pancreatic ..
  6. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    b>Gastroparesis is a common disease defined as the delayed emptying of the stomach...
  7. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2009
    ..mechanotranscription may also be involved in other stretch-related motility disorders such as achalasia and gastroparesis, where lack of relaxation of lower esophageal sphincter and pylorus sphincter is associated with distension ..
  8. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2010
    ..mechanotranscription may also be involved in other stretch-related motility disorders such as achalasia and gastroparesis, where lack of relaxation of lower esophageal sphincter and pylorus sphincter is associated with distension ..
  9. Gastric dysreflexia after spinal cord injury
    Gregory Holmes; Fiscal Year: 2009
    ..medulla is disrupted, resulting in an excitation of well documented medullary circuits that produce a spastic gastroparesis similar to truncal vagotomy...
  10. Gastric dysreflexia after spinal cord injury
    Gregory M Holmes; Fiscal Year: 2010
    ..medulla is disrupted, resulting in an excitation of well documented medullary circuits that produce a spastic gastroparesis similar to truncal vagotomy...
  11. Mechanisms underlying regional differences in gastric compliance in the stomach.
    Sean M Ward; Fiscal Year: 2010
    Millions of patients with functional dyspepsia and gastroparesis, both idiopathic and that associated with diabetes mellitus, have impaired postprandial gastric meal accommodation and uncoordinated gastric contractions which are often ..
  12. Mechanisms underlying regional differences in gastric compliance in the stomach.
    Sean Ward; Fiscal Year: 2009
    Millions of patients with functional dyspepsia and gastroparesis, both idiopathic and that associated with diabetes mellitus, have impaired postprandial gastric meal accommodation and uncoordinated gastric contractions which are often ..
  13. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..to nausea treatment in a large number of clinical situations, including cancer chemotherapy, diabetic gastroparesis, anorexia nervosa, ischemic gastropathy, chronic intestinal obstruction, abdominal malignancy, and functional ..
  14. INTERSTITIAL CELL OF CAJAL IN VAGAL AFFERENT SENSITIVITY
    Sean Ward; Fiscal Year: 2004
    ..Millions of patients with functional dyspepsia and gastroparesis, both idiopathic and that associated with diabetes mellitus, have low vagal tone and impaired postprandial ..
  15. Dual Pulse Electrical Stimulation for Gastroparesis
    Jiande Chen; Fiscal Year: 2007
    b>Gastroparesis is defined as delayed emptying of solids and is a common disease defined as delayed emptying of the stomach...
  16. Gastroparesis Gastric Dysrhythmias and Dyspepsia Symp*
    Kenneth Koch; Fiscal Year: 2007
    Type 2 diabetes mellitus (T2DM) afflicts 14 million patients; many patients have undiagnosed gastroparesis (GP) and suffer from nausea, bloating, and abdominal discomfort...
  17. Novel Evaluation & Treatment of Gastric Dysmotility
    Henry Parkman; Fiscal Year: 2007
    Gastric dysmotility is relevant in several clinical disorders including gastroparesis and functional dyspepsia...
  18. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..from the Applicant's Abstract): Impairment of gastric adaptive relaxation reflexes is an underlying cause of gastroparesis. It may also contribute to gastroesphageal reflux disease and metaplasia (Barretts)...