megacolon

Summary

Summary: Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.

Top Publications

  1. ncbi [Ulcerations in Chagas' megacolon operated at urgency and electively]
    Augusto Diogo-Filho
    Departamento de Cirurgia, Universidade Federal de Uberlandia, MG
    Arq Gastroenterol 43:280-3. 2006
  2. ncbi Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells
    Alexandre Barcelos Morais da Silveira
    Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, CEP 31270 901 Pampulha, Belo Horizonte, Minas Gerais, Brazil
    Hum Pathol 38:1256-64. 2007
  3. doi Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient
    Oscar Flórez
    Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia
    Parasitol Res 107:439-42. 2010
  4. doi Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients
    Gerd Wallukat
    Max Delbrück Centrum Berlin, Berlin, Germany
    J Am Coll Cardiol 55:463-8. 2010
  5. ncbi Association of megacolon with two recessive spotting genes in the mouse
    P W Lane
    J Hered 57:29-31. 1966
  6. ncbi Total proctocolectomy and ileal J-pouch anal anastomosis for chagasic megacolon with fecaloma: report of a case
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Surg Today 36:277-9. 2006
  7. doi Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly man
    Yi Hsuan Lin
    Division of Digestive Therapeutic Endoscopy, Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao Yuan, Taiwan
    J Med Virol 82:638-41. 2010
  8. ncbi Association of chagasic megacolon and cancer of the colon: case report and review of the literature
    Sheila Jorge Adad
    Disciplina de Patologia Especial, Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brazil
    Rev Soc Bras Med Trop 35:63-8. 2002
  9. doi Substance P and NK1 receptor expression in the enteric nervous system is related to the development of chagasic megacolon
    Alexandre B M da Silveira
    Research Center Rene Rachou, FIOCRUZ, Av Augusto de Lima, 1715, Barro Preto, Belo Horizonte, MG, Brazil
    Trans R Soc Trop Med Hyg 102:1154-6. 2008
  10. ncbi Cell-mediated immune response in megacolon from patients with chronic Chagas' disease
    C E Corbett
    Department of Pathology, School of Medicine, , Av. Dr. Amaldo 455, , Brazil
    Dis Colon Rectum 44:993-8. 2001

Detail Information

Publications180 found, 100 shown here

  1. ncbi [Ulcerations in Chagas' megacolon operated at urgency and electively]
    Augusto Diogo-Filho
    Departamento de Cirurgia, Universidade Federal de Uberlandia, MG
    Arq Gastroenterol 43:280-3. 2006
    corrected] The megacolon is a frequent disease in our emergencie hospital, and approached in the urgency by your complications as fecal impaction, volvulus and perforations...
  2. ncbi Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells
    Alexandre Barcelos Morais da Silveira
    Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, CEP 31270 901 Pampulha, Belo Horizonte, Minas Gerais, Brazil
    Hum Pathol 38:1256-64. 2007
    ..the Chagas disease parasite, Trypanosoma cruzi, some patients who are serologically positive develop chronic megacolon and megaesophagus, whereas others are symptom-free...
  3. doi Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient
    Oscar Flórez
    Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia
    Parasitol Res 107:439-42. 2010
    Chagasic megacolon has been reported in the southern cone countries of South America and is mainly associated with Trypanosoma cruzi II infection...
  4. doi Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients
    Gerd Wallukat
    Max Delbrück Centrum Berlin, Berlin, Germany
    J Am Coll Cardiol 55:463-8. 2010
    ..the patterns of autoantibodies (AAB) against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon and the discovery of such a pattern in patients who are as yet asymptomatic could help to identify patients at ..
  5. ncbi Association of megacolon with two recessive spotting genes in the mouse
    P W Lane
    J Hered 57:29-31. 1966
  6. ncbi Total proctocolectomy and ileal J-pouch anal anastomosis for chagasic megacolon with fecaloma: report of a case
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Surg Today 36:277-9. 2006
    b>Megacolon, resulting in severe constipation, is one of the most common manifestations of Chagas' disease. We herein report a case of megacolon with fecaloma in a 39-year-old Brazilian man who presented with severe constipation...
  7. doi Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly man
    Yi Hsuan Lin
    Division of Digestive Therapeutic Endoscopy, Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao Yuan, Taiwan
    J Med Virol 82:638-41. 2010
    ..by poor improvement of his symptoms after the CMV infection was treated with ganciclovir, and the occurrence of megacolon. A repeat colonoscopy with biopsy revealed a recurrence of the CMV infection...
  8. ncbi Association of chagasic megacolon and cancer of the colon: case report and review of the literature
    Sheila Jorge Adad
    Disciplina de Patologia Especial, Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brazil
    Rev Soc Bras Med Trop 35:63-8. 2002
    There are few descriptions of association between chagasic megacolon and colon cancer. We report a case of obstructive abdomen caused by adenocarcinoma of the left colon in chagasic megacolon...
  9. doi Substance P and NK1 receptor expression in the enteric nervous system is related to the development of chagasic megacolon
    Alexandre B M da Silveira
    Research Center Rene Rachou, FIOCRUZ, Av Augusto de Lima, 1715, Barro Preto, Belo Horizonte, MG, Brazil
    Trans R Soc Trop Med Hyg 102:1154-6. 2008
    Chagasic megacolon is one of the most important forms of Chagas disease. This form is characterized by inflammation, neuronal destruction and organ dilatation...
  10. ncbi Cell-mediated immune response in megacolon from patients with chronic Chagas' disease
    C E Corbett
    Department of Pathology, School of Medicine, , Av. Dr. Amaldo 455, , Brazil
    Dis Colon Rectum 44:993-8. 2001
    ..that control chronic infection in vivo and the immunologic mechanisms involved in the pathogenesis of chagasic megacolon are not completely characterized...
  11. ncbi Morphometric study of eosinophils, mast cells, macrophages and fibrosis in the colon of chronic chagasic patients with and without megacolon
    A B M da Silveira
    Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Parasitology 134:789-96. 2007
    The mechanisms involved in the pathogenesis of chagasic megacolon are not completely characterized...
  12. pmc Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolon
    B P Herring
    Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    J Biol Chem 274:17725-32. 1999
    ..These transgenic mice thus represent a novel model of megacolon that results from increased smooth muscle cell proliferation rather than altered neuronal innervation.
  13. ncbi Trypanosoma cruzi: typing of genotype (sub)lineages in megacolon samples from bolivian patients
    Myrna Virreira
    Laboratoire de Chimie Biologique, Faculte de Medecine, Universite Libre De Bruxelles U L B, Brussels, Belgium
    Acta Trop 100:252-5. 2006
    ..distributed evenly, therefore, we investigated the possible relationship between parasite (sub)lineages in megacolon patients. We typified the T...
  14. doi Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon
    Alexandre B M da Silveira
    Biomedical Institut Sciences, Universidade Federal de Uberlandia, Brazil
    Hum Immunol 70:65-7. 2009
    Patients with Chagas's disease in the chronic phase regularly present with the chagasic megacolon. This form is characterized by inflammation, neuronal destruction, and organ dilatation...
  15. ncbi Strategy for the surgical management of patients with idiopathic megarectum and megacolon
    C B O Súilleabháin
    Department of Coloproctology, Royal Infirmary, Glasgow G32 2ER, UK
    Br J Surg 88:1392-6. 2001
    ..Several surgical procedures have been used to treat idiopathic megabowel. A structured approach to the surgical management of megarectum/colon is reported...
  16. ncbi The enteric nervous system in chagasic and idiopathic megacolon
    Guido Iantorno
    Digestive Motility Section, Dr C B Udaondo Hospital, Buenos Aires, Argentina
    Am J Surg Pathol 31:460-8. 2007
    Chagas disease frequently causes megacolon. We investigated the enteric nervous systems in patients with chagasic megacolon compared to idiopathic megacolon and controls...
  17. ncbi Neurochemical coding of the enteric nervous system in chagasic patients with megacolon
    A B M da Silveira
    Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antônio Carlos 627, Pampulha, Belo Horizonte, Minas Gerais, CEP, 31270 901, Brazil
    Dig Dis Sci 52:2877-83. 2007
    Neuronal destruction has been considered the hallmark of pathogenic mechanisms in chagasic megacolon. Characterization of neuropeptides in the enteric nervous system from chagasic patients with megacolon could elucidate some aspects of ..
  18. ncbi Giant fecaloma with idiopathic sigmoid megacolon: report of a case and review of the literature
    Ambil Rajagopal
    Department of Surgery, PSG Institute of Medical Sciences and Research, Coimbatore, India
    Dis Colon Rectum 45:833-5. 2002
    ..This is a report of a giant, solitary, and stubborn fecaloma not responding to nonoperative management. A surgical intervention for uncomplicated fecal impaction is rarely needed and reported in the literature...
  19. ncbi Surgical treatment of Chagas megacolon. Critical analysis of outcome in operative methods
    Ricardo Luiz Santos Garcia
    Division of Coloproctology, Department of Surgery and Anatomy, Ribeirao Preto Faculty of Medicine, University of Sao Paulo, SP, Brazil
    Acta Cir Bras 23:83-92; discussion 92. 2008
    Surgical treatment of chagasic megacolon has suffered innumerable transformations over the years. Poor knowledge of the disease physiopathology is one of the reasons.
  20. ncbi Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon
    Thilo Wedel
    Department of Anatomy, Medical Universitiy of Luebeck, Luebeck, Germany
    Gastroenterology 123:1459-67. 2002
    ..This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 severe human colorectal motility disorders...
  21. ncbi Prevalence of rectoanal inhibitory reflex in chagasic megacolon
    Simone Cavenaghi
    Service of Physiotherapy, Department of Neurological Sciences, Hospital de Base, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil
    Arq Gastroenterol 45:128-31. 2008
    Rectoanal inhibitory reflex is not always evident in patients with chagasic megacolon. This may be due to insufficient volumes of air used during insufflation for the manometric examination.
  22. ncbi Megacolon and stercoral proctitis after frequent fecal impactions: report of an unusual case and review of the literature
    Jen Tzer Gau
    Department of Geriatric Medicine Gerontology, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
    J Am Med Dir Assoc 8:338-41. 2007
    Persistent megacolon that results from frequent episodes of fecal impaction without adequate treatment is a rare and seldom reported condition in the elderly...
  23. ncbi A case of megacolon in Rio Grande valley as a possible case of Chagas disease
    Karl Reinhard
    School of Natural Resource Sciences, 214 Bessey Hall, University of Nebraska Lincoln, Lincoln, NE 68588 0340, USA
    Mem Inst Oswaldo Cruz 98:165-72. 2003
    ..Specifically, we have looked for evidence of alteration of intestinal or fecal morphology consistent with megacolon, a condition associated with Chagas disease...
  24. pmc A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice
    M Hatano
    Division of Developmental Genetics, Chiba University School of Medicine, Chiba 260, Japan
    J Clin Invest 100:795-801. 1997
    ..The homozygous mutant mice were viable. These mice developed megacolon with enteric ganglia by age 3-5 wk...
  25. ncbi Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
    S Shirasawa
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 3:646-50. 1997
    ..Enx-deficient mice develop megacolon with massive distension of the proximal colon...
  26. ncbi Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis
    S J Adad
    Discipline of Special Pathology, Patologia Especial Hospital Escola Faculdade de Medicina do Triângulo Mineiro, Rua Getúlio Guaritá 130, Uberaba MG, 38025 440, Brazil
    Virchows Arch 438:254-8. 2001
    ..measured on paraffin sections in a ring from the sigmoid in Chagas' disease patients, 17 with and 10 without megacolon and in 10 non-chagasic controls. All neurons were counted in ten en-echelon sections...
  27. pmc Systematic review of surgical options for idiopathic megarectum and megacolon
    Marc A Gladman
    Centre for Academic Surgery Gastrointestinal Physiology Unit, Barts, London, UK
    Ann Surg 241:562-74. 2005
    ..The aim of this systematic review was to evaluate the published outcome data of surgical procedures for IMB in adults...
  28. ncbi [Disturbances of small intestinal motility in patients with chronic constipation]
    Ana Maria Madrid
    Sección de Gastroenterología, Departamento de Medicina, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Rev Med Chil 134:181-6. 2006
    ..Studies in patients with chronic severe constipation, suggest the presence of a diffuse motor disorder of the gastrointestinal tract...
  29. ncbi Morphometric study of the fibrosis and mast cell count in the circular colon musculature of chronic Chagas patients with and without megacolon
    Simone Wanderley Pinheiro
    Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brasil
    Rev Soc Bras Med Trop 36:461-6. 2003
    ..The objective was to gain better understanding of Chagas megacolon morphology and contribute towards the knowledge of fibrosis pathogenesis in Chagas megas...
  30. doi Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development
    A B M da Silveira
    Research Center Rene Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    Parasitology 135:1337-42. 2008
    ..However, some pathological aspects of the chagasic megasyndromes are still incompletely understood. Chagasic megacolon is characterized by an inflammatory process, organ dilatation and neuronal reduction in both plexuses of the ..
  31. ncbi Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
    Mattias Ormestad
    Department of Cell and Molecular Biology, Goteborg University, Goteborg, Sweden
    Development 133:833-43. 2006
    ..Inactivation of both Foxf2 alleles, or one allele each of Foxf1 and Foxf2, cause a range of defects, including megacolon, colorectal muscle hypoplasia and agangliosis...
  32. ncbi Surgical treatment of chagasic megacolon: Duhamel-Haddad procedure is also a good option
    Fabio V Teixeira
    Dis Colon Rectum 46:1576; author reply 1577-8. 2003
  33. ncbi Pneumatic dilatation in achalasia of the esophagus: a report from Argentina
    G B Salis
    Servicio de Gastroenterologia, Hospital Profesor Alejandro Posadas, El Palomar, Argentina
    Dis Esophagus 17:124-8. 2004
    ....
  34. ncbi Transverse to descending colon volvulus and megacolon with mesenterium commune: report of a case
    Satoru Tobinaga
    Department of Surgery, Chikugo City Hospital, Fukuoka, Japan
    Surg Today 34:875-7. 2004
    We report a case of volvulus of the transverse-descending (T-D) colon and megacolon associated with mesenterium commune. A 70-year-old man was referred to our hospital for investigation of severe constipation and abdominal fullness...
  35. ncbi [Features of Chagas' disease patients with emphasis on digestive form, in a tertiary hospital of Ribeirão Preto, SP]
    Mayra Mayumi Kamiji
    Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, R Fiorígio Casilo 48 22, Santa Cruz, 14020 685 Ribeirão Preto, Sao Paulo, Brazil
    Rev Soc Bras Med Trop 38:305-9. 2005
    ..Median age was 67 years and 210 (56%) were women. Megaesophagus and/or megacolon were present in 135 patients, 59% of these had cardiopathy...
  36. ncbi [Cystic mass of the pancreatic region associated with elevated CA 19-9 serum levels revealing a colonic duplication in an adult]
    Jean Rémy Legros
    Service de Chirurgie Generale et Digestive, Hopital Charles Nicolle, Rouen
    Gastroenterol Clin Biol 28:1291-3. 2004
    ..Although the physiopathology of the expression of CA 19-9 in duplications is unclear, this feature has been recently reported in adults and could be of interest in the diagnosis and management of intestinal duplications...
  37. ncbi Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon
    Jung Il Lee
    Department of Internal Medicine, Inha University of Medicine, Incheon, Seoul, Korea
    J Gastroenterol Hepatol 20:1292-8. 2005
    ..The aims of the present study were to assess the distribution of ICC and neuronal cells of ENS in patients with slow-transit constipation and acquired megacolon.
  38. ncbi [Gastrointestinal motility disturbances in Chagas disease]
    Ana Maria Madrid
    Servicio de Medicina, Sección de Gastroenterología, Hospital Clinico de la Universidad de Chile, Santiago, Chile
    Rev Med Chil 132:939-46. 2004
    ..Chagas disease is rarely an aetiological factor for achalasia in Chile, which is different from reports in other countries of South America. In contrast, a high incidence of megacolon among these patients have been reported.
  39. ncbi Persistent obstructive symptoms after surgery for Hirschsprung's disease: development of a diagnostic and therapeutic algorithm
    Jacob C Langer
    University of Toronto and Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Surg 39:1458-62. 2004
    ..The author's goal was to develop an organized algorithm for the workup and ultimate management of these symptoms...
  40. ncbi Surgical treatment of Chagasic megacolon by abdominal rectosigmoidectomy with immediate posterior end-to-side stapling (Habr-Gama technique)
    Sergio C Nahas
    Department of Gastroenterology, Colorectal Surgery Division, University of Sao Paulo, School of Medicine, Rua Jabebira 136, 05602 020 São Paulo, SP, Brazil
    Dis Colon Rectum 49:1371-8. 2006
    Various techniques have been used in the surgical treatment of Chagasic megacolon, including sympathectomy, sphincterotomy, anterior abdominal resection with high or low anastomosis, pull-through procedures, and Duhamel technique...
  41. ncbi Adult Hirschsprung's disease diagnosed during forensic autopsy
    Denis Chatelain
    Department of Pathology, centre hospitalier universitaire d Amiens, Place Victor Pauchet, 80054 Amiens cedex 01, France
    J Forensic Sci 51:1160-3. 2006
    ..He had a past history of chronic constipation since infancy. Forensic autopsy revealed a megacolon full of gas and stools...
  42. doi Decreased expression of IK channels in neurons from enteric nervous system is associated with the development of chagasic megacolon
    Alexandre B M da Silveira
    Hum Pathol 39:1406-7. 2008
  43. doi Multimedia article. Laparoscopic-assisted rectosigmoidectomy with ileal loop interposition. Surgical treatment of chagasic megacolon
    Eloy Espin-Basany
    Colorectal Surgery Unit, Hospital Valle de Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Dis Colon Rectum 51:1421. 2008
    Chagas disease is a frequent cause of acquired megacolon in several countries of Latin America. Several procedures have been described to treat this condition...
  44. doi Clinical challenges and images in GI. Hindgut dysgenesis with megacolon
    Seth Sweetser
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 134:1293, 1635. 2008
  45. doi The different concentrations of mast cells in the musculature of the esophagus and the colon
    Simone Wanderley Pinheiro
    Hum Pathol 39:793; author reply 793. 2008
  46. ncbi The usefulness of ultrasound examination of the bowel as a method of assessment of functional chronic constipation in children
    Artur Bijoś
    Medical Faculty, University of Rzeszow, Warszawska 26a, Rzeszow, Poland
    Pediatr Radiol 37:1247-52. 2007
    ..Ultrasonographic assessment of stool retention in children with chronic constipation requires the diagnosis of megarectum...
  47. ncbi [Megarectum and anismus: a cause of constipation]
    Y Real Martínez
    Servicio de Aparato Digestivo, Hospital Virgen de la Torre, Madrid
    Rev Esp Enferm Dig 99:352-3. 2007
  48. ncbi [Effect of combined drug treatment on megacolon with severe constipation]
    Zhao lu Ding
    Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:670-2. 2007
    To assess the effectiveness of combined drug treatment on megacolon complicated by severe constipation.
  49. ncbi Recurrence of chagasic megacolon after surgical treatment: clinical, radiological, and functional evaluation
    Sergio Eduardo Alonso Araujo
    Clinics (Sao Paulo) 62:89-92. 2007
  50. ncbi Idiopathic megacolon
    Frank Autschbach
    University Heidelberg, Institute of Pathology, Heidelberg, Germany
    Eur J Gastroenterol Hepatol 19:399-400. 2007
    ..The pathogenesis of idiopathic megacolon. Eur J Gastroenterol Hepatol 2006; 18:1209-1215...
  51. ncbi Multiple clinical presentations of anal ultra slow waves and high anal pressure: megacolon, hemorrhoids and constipation
    Hiroaki Yoshino
    Department of Pediatric Surgery, Akita University School of Medicine, Japan
    Tohoku J Exp Med 211:127-32. 2007
    ..In the manometric studies of the patients with severe chronic constipation, we noticed that some patients with megacolon show very slow periodical (< 2/min) pressure change in the anal canal, namely ultra slow waves (USWs)...
  52. ncbi [Hypoganglionosis as a cause of chronic constipation]
    E Bruder
    Institut fur Pathologie, Universitatsspital Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Pathologe 28:131-6. 2007
    ..Similar to Hirschsprung's disease, hypoganglionosis may be complicated by megacolon formation and must be considered in the differential diagnosis...
  53. ncbi Comparison of biofragmentable anastomosis ring and sutured anastomoses for subtotal colectomy in cats with idiopathic megacolon
    Stewart Ryan
    Colorado State University Veterinary Medical Center, Fort Collins, CO, USA
    Vet Surg 35:740-8. 2006
    To report use of a biofragmentable anastomosis ring (BAR) device in cats with idiopathic megacolon (FIM) and compare outcome after subtotal colectomy with sutured colocolic anastomosis.
  54. ncbi The pathogenesis of idiopathic megacolon
    William A Meier-Ruge
    Department of Pathology, University Medical School, Basel, Switzerland
    Eur J Gastroenterol Hepatol 18:1209-15. 2006
    Even today, the pathogenesis of idiopathic megacolon is still a subject of controversy. Anomalies of the gastrointestinal autonomous nervous system or of the smooth muscle of the muscularis propria are being considered.
  55. ncbi Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil
    Alexandre Fernandes
    Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 103:514-6. 2008
    We evaluated the presence and distribution of Trypanosoma cruzi DNA in a mummy presenting with megacolon that was dated as approximately 560 +/- 40 years old. The mummy was from the Peruaçu Valley in the state of Minas Gerais, Brazil...
  56. ncbi Strategy for the surgical management of patients with idiopathic megarectum and megacolon (Br J Surg 2001;88:1392-6)
    M A Gladman
    Br J Surg 89:623. 2002
  57. ncbi Morphologic and morphometric evaluation of pancreatic islets in chronic Chagas' disease
    J C Saldanha
    Department of Pathology, Faculty of Medicine, Triangulo, Mineiro
    Rev Hosp Clin Fac Med Sao Paulo 56:131-8. 2001
    ..CONCLUSION: The observed morphometric and morphologic alterations are consistent with functional changes in the pancreas, including glycemia and insulin disturbances...
  58. ncbi [Differential surgical treatment of idiopathic megadolichocolon in adults]
    V M Bensman
    Vestn Khir Im I I Grek 161:33-7. 2002
    ..A new operation--endofascial resection of the rectum--is proposed for treatment of proctogenic SCC. The differential surgical strategy with pathomorphogenesis of SCC taken into account allowed to get satisfactory results in 73% of cases...
  59. pmc Interaction of human chagasic IgG with human colon muscarinic acetylcholine receptor: molecular and functional evidence
    L Sterin-Borda
    Pharmacology Unit, School of Medicine and Dentistry, University of Buenos Aires, Argentina
    Gut 49:699-705. 2001
    ..The pathogenesis seems to be associated with autonomic dysfunction. Here, we consider the muscarinic cholinoceptor mediated alteration in distal colon function in chagasic megacolon.
  60. ncbi Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 gene
    V M Tennyson
    Department of Anatomy, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Dyn 211:269-91. 1998
    b>Megacolon occurs in neonatal and adult transgenic mice that overexpress the Hoxa-4 gene...
  61. ncbi Surgical management of constipation
    R N White
    Davies White Veterinary Specialists, Higham Gobion, Hitchin, Hertfordshire
    J Feline Med Surg 4:129-38. 2002
    ..Most surgery therapies for constipation in the cat are related to the management of idiopathic megacolon, although causes such as pelvic outlet obstruction, complications of neutering surgery, perineal herniation, and ..
  62. ncbi Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations
    B Chen
    Department of Paediatric Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Neurogastroenterol Motil 14:513-7. 2002
    Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology...
  63. ncbi Histologic criteria for the diagnosis of allied diseases of Hirschsprung's disease in adults
    K Munakata
    First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
    Eur J Pediatr Surg 12:186-91. 2002
    ....
  64. ncbi Constipation and megacolon in rats related to treatment with oxodipine, a calcium antagonist
    A Nyska
    Kimron Veterinary Institute, Beit Dagan, Israel
    Toxicol Pathol 22:589-94. 1994
    ..This paper reports the occurrence of megacolon in rats as a result of the constipatory effects of chronic administration of oxodipine...
  65. ncbi Recurrent sigmoid volvulus in a sixteen-year-old boy: case report and review of the literature
    Mimi N Ton
    Division of Gastroenterology and Nutrition, Children s Hospital of New York, Columbia University, New York, NY 10032, USA
    J Pediatr Surg 39:1434-6. 2004
    ..Several months after surgery, he remains free of symptoms and is doing well. A review of the literature illustrates the approach to this problem from ancient times until now...
  66. ncbi Distribution and development of peptidergic nerves and gut endocrine cells in mice with congenital aganglionic colon, and their normal littermates
    C Vaillant
    Gastroenterology 82:291-300. 1982
    ..Thus the findings of normal populations of gut endocrine cells in the aganglionic segment is further support for the view that the embryologic origin of gut endocrine cells is different to that of gut neurons...
  67. ncbi Simultaneous decompression colonoscopy and radiologic G-tube insertion in a patient with megacolon because of chronic colonic pseudo-obstruction
    Alain Attar
    Hopital Avicenne, Bobigny
    Gastrointest Endosc 62:975-6; discussion 976. 2005
  68. ncbi Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study
    T Arvola
    Medical School, University of Tampere and the Department of Pediatrics, Tampere University Hospital, Tampere, Finland
    Pediatrics 104:e64. 1999
    ..diarrhea with electrolyte disturbances, dehydration, crampy abdominal pain, pseudomembranous colitis, toxic megacolon, or even death. The incidence of diarrhea in children receiving a single antimicrobial treatment is unclear...
  69. ncbi Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia
    A J Burns
    Institut d Embryologie Cellulaire et Moleculaire, College de France et CNRS, Nogent sur Marne, 94736, France
    Dev Biol 219:30-43. 2000
    ..to compensate for the lack of ganglia in the terminal hindgut of Hirschsprung's disease in humans or aganglionic megacolon in animals...
  70. ncbi Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)
    Jose A Castro
    Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, J B de La Salle 4397, Villa Martelli, Pcia de Buenos Aires 1603, Argentina
    Hum Exp Toxicol 25:471-9. 2006
    ..of the survivors develop chronic Chagas' disease, which is characterized by potentially lethal cardiopathy and megacolon or megaoesophagus...
  71. ncbi Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004
    Frederic Barbut
    Service de Microbiologie, Hopital Saint Antoine, Paris, 75012, France
    Infect Control Hosp Epidemiol 28:131-9. 2007
    ..Recent outbreaks of severe cases of Clostridium difficile-associated diarrhea (CDAD) reported in North America, the United Kingdom, and The Netherlands have emphasized the importance of an ongoing epidemiological surveillance of CDAD...
  72. ncbi Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene
    V M Tennyson
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Dev Dyn 198:28-53. 1993
    Congenital megacolon develops in transgenic mice that overexpress the homeobox-containing gene, Hoxa-4. The current study was done to identify abnormalities of the terminal colon that might account for the phenotype...
  73. pmc Outcome following emergency surgery for refractory severe ulcerative colitis in a tertiary care centre in India
    Sujoy Pal
    Department of GI Surgery and Liver Transplantation, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    BMC Gastroenterol 5:39. 2005
    ....
  74. ncbi Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 cases
    Susanna E Palmer
    Te Korowai Whariki Mental Health Services, Capital and Coast District Health Board, Wellington, New Zealand
    J Clin Psychiatry 69:759-68. 2008
    ..To raise awareness of potentially lethal clozapine-induced gastrointestinal hypomotility (CIGH) by reviewing cases from the literature and unpublished pharmacovigilance data and to offer strategies aimed at prevention and early treatment...
  75. pmc Lineage analysis of circulating Trypanosoma cruzi parasites and their association with clinical forms of Chagas disease in Bolivia
    Ramona del Puerto
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Nagasaki, Japan
    PLoS Negl Trop Dis 4:e687. 2010
    ..blood samples from three different clinical groups of chronic Chagas disease patients (indeterminate, cardiac, megacolon) from Bolivia were analyzed for their circulating parasites lineages using minicircle kinetoplast DNA ..
  76. ncbi Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity
    Seungil Ro
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, 89557, USA
    Am J Physiol Gastrointest Liver Physiol 290:G710-8. 2006
    It has been assumed that in piebald lethal mice that develop megacolon, impaired colonic motor activity is restricted to the aganglionic distal colon...
  77. ncbi [The development of a toxic megacolon due to Amanita phalloides poisoning. A rare complication]
    F Eyer
    Toxikologische Abteilung der II Medizinischen Klinik, Klinikum rechts der Isar Technische Universität München, Munchen, Germany
    Dtsch Med Wochenschr 129:137-40. 2004
    ..Other than a transient tachycardia and diffuse pain on abdominal palpation clinical examination was without abnormal findings...
  78. ncbi Augmented unilateral gluteoplasty with fascia lata graft in fecal incontinence
    M Farid
    Colorectal Surgery Unit, Mansoura University Hospital, P O Box 324, Mansoura, Egypt
    Tech Coloproctol 7:23-8; discussion 28. 2003
    ..This study was undertaken to evaluate the results of augmented unilateral gluteoplasty with fascia lata graft in patients with fecal incontinence due to congenital or neurologic disorders...
  79. pmc Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
    Jacques Pepin
    Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
    CMAJ 171:466-72. 2004
    ..difficile-associated diarrhea (CDAD) in our institution. We describe cases of CDAD at our institution over a 13-year period and investigate changes in illness severity...
  80. doi Characterization of clinical Clostridium difficile isolates by PCR ribotyping and detection of toxin genes in Austria, 2006-2007
    A Indra
    Austrian Agency for Health and Food Safety AGES, Waeringerstrasse 25a, A 1090 Vienna, Austria
    J Med Microbiol 57:702-8. 2008
    ..7%), as pseudomembranous colitis in 15 cases (10.6%) and as toxic megacolon in one case. Twelve of the 142 patients died within 30 days of specimen collection (8.45% lethality)...
  81. ncbi A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease
    W J Pavan
    Laboratory for Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 6:1-7. 1995
    Mice homozygous for the lethal spotting (ls) mutation exhibit aganglionic megacolon and a white spotted coat owing to a lack of neural crest-derived enteric ganglia and melanocytes...
  82. doi Defining surgical therapy for pseudomembranous colitis with toxic megacolon
    Loren Berman
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Clin Gastroenterol 42:476-80. 2008
    Pseudomembranous colitis has increased in incidence and severity over the past 10 years. Toxic megacolon is a rare but reported presentation of severe pseudomembranous colitis...
  83. ncbi [Long-term outcomes of ileal pouch after secondary diagnosis of Crohn's disease]
    Maria de Lourdes Setsuko Ayrizono
    Grupo de Coloproctologia, Departamento de Cirurgia e Departamento de Anatomia Patológica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Sao Paulo, SP, Brazil
    Arq Gastroenterol 45:204-7. 2008
    ..Total rectocolectomy and ileal pouch-anal anastomosis is the choice surgical procedure for patients with ulcerative colitis. In cases of Crohn's disease post-operative diagnosis, it can be followed by pouch failure...
  84. doi The thyroid and the gut
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    J Clin Gastroenterol 44:402-6. 2010
    ..Constipation may result from diminished motility, leading to an ileus, megacolon, or rarely pseudoobstruction. Ascites in myxedema is characterized by a high protein concentration...
  85. pmc Clostridium difficile associated infection, diarrhea and colitis
    Perry Hookman
    University of Miami Miller School of Medicine, Division of Gastroenterology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    World J Gastroenterol 15:1554-80. 2009
    ..Before 2002, toxic megacolon in C. difficile-associated colitis (CDAC), was rare, but its incidence has increased dramatically...
  86. pmc An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case report
    David L Suskind
    Department of Pediatrics, Seattle Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, Seattle, Washington, USA
    BMC Gastroenterol 4:26. 2004
    ..Ulcerative colitis has been associated with disseminated intravascular coagulation in conjunction with septicemia, toxic megacolon and surgery.
  87. ncbi [When is it too early or too late for surgery in Crohn's disease? ]
    J I Fernández-Blanco Hernáiz
    Servicio de Cirugia General, Hospital Universitario La Paz, Madrid
    Rev Esp Enferm Dig 100:35-44. 2008
    ..indications for initial selective surgery in management of CD patient like: Massive intestinal bleeding, toxic megacolon or free perforation, other surgical conditions they should be reevaluated on light of our current knowledge...
  88. ncbi Chronic constipation - the role of clinical assessment and colorectal physiologic tests to obtain an etiologic diagnosis
    Antônio Lacerda-Filho
    Alfa Institute of Gastroenterology, Federal University of Minas Gerais Medical School, Belo Horizonte, MG, Brazil
    Arq Gastroenterol 45:50-7. 2008
    ..Although colorectal physiologic tests have brought an important contribution, it remains unclear in which patients these tests should be indicated for...
  89. doi The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: report of a case
    Eiji Mekata
    Department of Surgery, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520 2192, Japan
    Surg Today 38:862-5. 2008
    A 53-year-old woman who was traveling in Australia was admitted to a local hospital with pyrexia and diarrhea. Megacolon was diagnosed from an X-ray and an emergency operation was performed...
  90. ncbi Current indications for blow-hole colostomy:ileostomy procedure. A single center experience
    Feza H Remzi
    Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195 USA
    Int J Colorectal Dis 18:361-4. 2003
    ..blow-hole colostomy with loop ileostomy is now rarely performed to reduce operative risks in patients with toxic megacolon related to inflammatory bowel disease (IBD)...
  91. ncbi [Role of fetal urine sampling in the prenatal diagnosis of malformative uropathies]
    Christophe Lopez
    Service d Urologie II, CHU Lapeyronie, Montpellier, France
    Prog Urol 12:1261-7. 2002
    ..To define the diagnostic and therapeutic value of foetal urine sampling (FUS)...
  92. ncbi [The Latin-American Consensus on Chronic Constipation]
    Max Schmulson Wasserman
    Laboratorio de Hígado, Páncreas y Motilidad HIPAM Departamento de Medicina Experimental Facultad de Medicina Universidad Nacional Autónoma de México UNAM Hospital General de México México
    Gastroenterol Hepatol 31:59-74. 2008
    ..barium enema as an initial investigation was recommended only in countries with a high prevalence of idiopathic megacolon or Chagas' disease...
  93. ncbi Toxic megacolon in Salmonella colitis: report of two cases
    M M Tiao
    Department of Pediatrics, Chang Gung Children s Hospital, Kaohsiung, Taiwan
    Acta Paediatr Taiwan 41:43-6. 2000
    Toxic megacolon is a complication that usually presents in inflammatory bowel disease such as ulcerative colitis or Crohn's disease...
  94. pmc A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection
    Patricia S Doyle
    Department of Pathology, University of California San Francisco, CA 94121, USA
    Antimicrob Agents Chemother 51:3932-9. 2007
    ..derive from infection of muscle cells leading to progressive cardiomyopathy, while some patients develop megacolon or megaesophagus...
  95. pmc Clinical severity of Clostridium difficile PCR ribotype 027: a case-case study
    Oliver W Morgan
    East of England Regional Epidemiology Unit, Health Protection Agency, Cambridge, United Kingdom
    PLoS ONE 3:e1812. 2008
    ..Several industrialised countries have reported increased C. difficile infections and outbreaks, which have been attributed to the emergent PCR ribotype 027 strain...
  96. ncbi Acute and chronic megacolon
    Stephen B Hanauer
    Arnold Wald, MD Section of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, H6 516 CSC, Madison, WI 53792 5124, USA
    Curr Treat Options Gastroenterol 10:237-47. 2007
    b>Megacolon, defined as dilation of the abdominal colon, may occur acutely or in a chronic form...
  97. ncbi Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada
    Jacques Pepin
    Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
    Clin Infect Dis 42:758-64. 2006
    ....
  98. ncbi Surgery for ulcerative colitis in elderly persons: changes in indications for surgery and outcome over time
    G Almogy
    Department of Surgery, Mount Sinai Hospital and the Mount Sinai School of Medicine, New York, NY, USA
    Arch Surg 136:1396-400. 2001
    ..Medical therapy has changed the indications for surgery over the last 4 decades. Advances in perioperative care have significantly improved the outcome...
  99. pmc Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color
    C E Gariepy
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235 9050, USA
    Proc Natl Acad Sci U S A 93:867-72. 1996
    Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital aganglionic megacolon and pigment abnormalities in mice and humans...
  100. ncbi Non-toxic megacolon due to transverse and sigmoid colon volvulus in a patient with ulcerative colitis
    Konstantinos Katsanos
    1st Department of Internal Medicine and Hepato Gastroenterology Unit, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    J Crohns Colitis 3:38-41. 2009
    ..2 g/dl and C-reactive protein at 310 mg/dl. Radiology was suggestive of megacolon and volvulus...
  101. ncbi Impaired growth and differentiation of diploid but not immortal melanoblasts from endothelin receptor B mutant (piebald) mice
    E V Sviderskaya
    St George s Hospital Medical School, London, United Kingdom
    Dev Dyn 213:452-63. 1998
    ..at either locus can show major deficiencies in both cell types: congenital white spotting and aganglionic megacolon (Hirschsprung disease in human)...

Research Grants71

  1. PI 3-KINASE AND KIT RECEPTOR SIGNALING
    Peter Besmer; Fiscal Year: 2000
    ..macrocytic anemia, mast cell deficiency anemia, mast cell deficiency, spotting, male and female sterility and megacolon. Based on mutant phenotypes the cellular responses mediated by the c- kit receptor are quite diverse and include:..
  2. Bioorganic Chemistry of Carbon Monoxide Dehydrogenase
    PAUL LINDAHL; Fiscal Year: 2007
    ..Health: Clostridium difficile, which contains this enzyme ACS/CODH, causes antibiotic-associated colitis, toxic megacolon, intestinal perforations and even death in humans...
  3. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    Hirschsprung disease, or aganglionic megacolon, is a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut ADDIN EN...
  4. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    Hirschsprung disease, or aganglionic megacolon, is a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut ADDIN EN...
  5. The Role of Selenium in Intestinal Inflammation and Cancer
    Linda Jelicks; Fiscal Year: 2007
    ..We have performed extensive cardiac imaging studies on these mice which develop cardiomegaly in addition to megacolon and megaesophagus. This disease involves inflammation of the GI tract without the development of tumors...
  6. Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolon
    MILES EPSTEIN; Fiscal Year: 2009
    ..The information gained here will also be relevant to transplantation of other tissues including neurons. ..
  7. Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolon
    Miles L Epstein; Fiscal Year: 2010
    ..The information gained here will also be relevant to transplantation of other tissues including neurons. ..
  8. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Investigator's Abstract): Hirschsprung disease (HSCR), or aganglionic megacolon, is a relatively common, multifactorial birth defect associated with the lack of intrinsic ganglion cells in the myenteric (..
  9. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2007
    Hirschsprung disease (HSCR), or aganglionic megacolon, is a relatively common, multifactorial birth defect associated with the lack of intrinsic ganglion cells in the myenteric (Auerbach) and submucosal (Meissner) plexuses in the ..
  10. BIOINORGANIC CHEMISTRY OF CARBON MONOXIDE DEHYDROGENASE
    PAUL LINDAHL; Fiscal Year: 2009
    ..Clostridium difficile, which contains this enzyme ACS/CODH, causes antibiotic-associated colitis, toxic megacolon, intestinal perforations and even death in humans...
  11. BIOINORGANIC CHEMISTRY OF CARBON MONOXIDE DEHYDROGENASE
    Paul A Lindahl; Fiscal Year: 2010
    ..Clostridium difficile, which contains this enzyme ACS/CODH, causes antibiotic-associated colitis, toxic megacolon, intestinal perforations and even death in humans...
  12. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2010
    ..to serious complications due to severe inflammation, like intestinal perforation, fistula formation and/or toxic megacolon. The two main subtypes of IBD, Crohn's Disease and Ulcerative Colitis, afflict an estimated 1...
  13. Control of neural crest development in Xenopus
    Jean Pierre Saint Jeannet; Fiscal Year: 2010
    ..affecting multiple organ systems, as observed in Hirschsprung disease (hypopigmentation and aganglionic megacolon) and DiGeorge syndrome (craniofacial and heart defects)...
  14. Role of Robo receptor in the formation of the enteric nervous system
    Maria Elena De Bellard; Fiscal Year: 2007
    ..goes from cleft palate (failure of the neural crest to close both sides of the face) to Hirschprung disease/Megacolon (failure of the neural crest to colonize the colon) to Neurofibromatosis (scattered small tumors of neural crest ..
  15. DEVELOPMENT OF NEURONS IN THE GUT
    MILES EPSTEIN; Fiscal Year: 1993
    ..Failure of crest cells to occupy regions of gut results in motility disorders. Congenital megacolon (Hirschsprung's disease) results from the absence of crest cells in the terminal bowel and pseudoobstruction may ..
  16. Genetic Complexity and Modifiers of Hirschsprung Disease
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..The primary clinical feature, aganglionic megacolon, arises as a consequence of anomalies in development of the enteric nervous system and subsequent absence of ..
  17. Genetic Complexity and Modifiers of Hirschsprung Disease
    E Southard Smith; Fiscal Year: 2007
    ..The primary clinical feature, aganglionic megacolon, arises as a consequence of anomalies in development of the enteric nervous system and subsequent absence of ..
  18. MRI METHODS FOR ANALYSIS OF BLADDER AND GI TRACT IN MICE
    Linda Jelicks; Fiscal Year: 2005
    ..The digestive disease leads to megaesophagus and/or megacolon in 1/3 of chronic cases...
  19. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 1990
    ..system; (4) to compare neuro-effector function in the large intestine of mice with hereditary aganglionic megacolon with neuro-effector function in mice with normal innervation of the bowel; (5) to analyze plasticity and ..
  20. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2004
    ..Congenital defects of the ENS are relatively common and may not all be as evident as congenital megacolon (Hirschsprung's disease; aganglionosis of the terminal bowel) or pseudoobstruction...