gastritis

Summary

Summary: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.

Top Publications

  1. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
  2. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
  3. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
  4. ncbi CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo
    Roland Rad
    Second Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
    Gastroenterology 131:525-37. 2006
  5. ncbi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
  6. pmc Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
    Jennifer L Lofgren
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Gastroenterology 140:210-20. 2011
  7. ncbi Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
    Paul R Harris
    Department of Pediatrics, Pontificia Universidad Católica de Chile and Hospital Dr Sótero del Río, Santiago, Chile
    Gastroenterology 134:491-9. 2008
  8. ncbi Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 426:342-9. 2012
  9. pmc CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice
    Mohammad S Alam
    Digestive Health Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0708, USA
    J Infect Dis 199:494-504. 2009
  10. pmc Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis
    Akira Yoshida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852 8501, Japan
    Clin Immunol 130:290-7. 2009

Detail Information

Publications311 found, 100 shown here

  1. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
    ..Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain...
  2. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..not clear, but the gastric physiological response is influenced by the severity and anatomical distribution of gastritis induced by H. pylori...
  3. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  4. ncbi CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo
    Roland Rad
    Second Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
    Gastroenterology 131:525-37. 2006
    ..It is unclear why the immune system is unable to eliminate the infection, but recent studies suggested that CD4+/CD25+/Foxp3+ regulatory T cells may be involved in this process...
  5. ncbi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    ..We assessed the association of new and established cagA and vacA polymorphisms with disease...
  6. pmc Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
    Jennifer L Lofgren
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Gastroenterology 140:210-20. 2011
    ..FVB/N insulin-gastrin (INS-GAS) mice have high circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal intraepithelial neoplasia (GIN) with 80% prevalence 6 months after Helicobacter pylori ..
  7. ncbi Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
    Paul R Harris
    Department of Pediatrics, Pontificia Universidad Católica de Chile and Hospital Dr Sótero del Río, Santiago, Chile
    Gastroenterology 134:491-9. 2008
    ....
  8. ncbi Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 426:342-9. 2012
    ..We investigated the expression and role of TLR9 in H. pylori-induced gastritis in mice. Expression of TLR9 mRNA in the gastric tissue increased after infection with H. pylori...
  9. pmc CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice
    Mohammad S Alam
    Digestive Health Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0708, USA
    J Infect Dis 199:494-504. 2009
    ..We investigated the expression of CD39 and CD73 on human T helper (Th) cells and the role of CD73 in regulating Helicobacter felis-induced gastritis and colonization.
  10. pmc Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis
    Akira Yoshida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852 8501, Japan
    Clin Immunol 130:290-7. 2009
    ..pylori-infected and the uninfected groups. The CCL20 concentrations correlated with the degree of chronic gastritis. Immunohistochemistry and the in vitro infection assay showed that CCL20 was principally produced by the gastric ..
  11. pmc Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome
    Bai Jiang
    Bioinformatics Division, TNLIST and Department of Automation, Tsinghua University, Beijing 100084, China
    Sci Rep 2:936. 2012
    ..The study included 19 gastritis patients with a typical white-greasy or yellow-dense tongue coating corresponding to TCM Cold or Hot Syndrome ..
  12. ncbi Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis
    Osamu Hosokawa
    Department of Surgery, Fukui Prefectural Hospital, 2 8 1 Yotsui, Fukui 910 8526, Japan
    Gastric Cancer 8:42-6. 2005
    Little is known about the natural course of multiple gastric carcinoids associated with type A gastritis. Between 1993 and 2003, we enrolled eight patients, diagnosed as having multiple gastric carcinoids associated with type A gastritis,..
  13. ncbi Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute and University of Queensland, Mater Misericordiae Hospitals, Brisbane, Australia
    Gastroenterology 133:1210-8. 2007
    ..We have evaluated the impact of Muc1 expression on the colonization and pathogenesis of gastric Helicobacter infections...
  14. ncbi Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice
    L E Smythies
    Department of Medicine, Pathology, and Comparative Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:1022-9. 2000
    To elucidate the pathogenesis of Helicobacter pylori-associated gastritis, we studied immune responses of C57BL/6J wild-type (WT), SCID, and gene deficient (IFN-gamma-/- and IL-4-/-) mice following infection with a pathogenic isolate of ..
  15. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  16. pmc Long term follow up of patients treated for Helicobacter pylori infection
    R Mera
    Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Gut 54:1536-40. 2005
    ..Understanding long term effects resulting from the cure of this infection is needed to design cancer prevention strategies...
  17. pmc Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis
    Yi Ying Wu
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, 1 Jen Ai Rd, Sec 1, Taipei 100, Taiwan
    Infect Immun 75:4357-63. 2007
    ..pylori infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. There is increased T-cell infiltration at the site of infection with H...
  18. ncbi The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210, USA
    J Immunol 166:7456-61. 2001
    b>Gastritis due to Helicobacter pylori in mice and humans is considered a Th1-mediated disease, but the specific cell subsets and cytokines involved are still not well understood...
  19. ncbi Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Gastrointest Endosc 70:246-53. 2009
    ..Magnifying narrow-band imaging (NBI) endoscopy clearly visualizes superficial gastric mucosal patterns and capillary patterns...
  20. ncbi Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:414-24. 2002
    ..The aim was to determine which H. pylori virulence factor(s) was the most important predictor of severity of gastric inflammation or clinical outcome...
  21. pmc Epstein Barr virus and Helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients
    María G Cárdenas-Mondragón
    Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias UIMEIP, Hospital de Pediatria, CMN Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Mexico City, Mexico
    PLoS ONE 8:e62850. 2013
    ..pylori infection remains poorly studied. Here, we assessed whether EBV infection in children correlated with the stage of gastritis and whether co-infection with H. pylori affected the severity of inflammation.
  22. ncbi Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions
    B R Achyut
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Hum Immunol 68:901-7. 2007
    ..Therefore we aimed to evaluate association of TLR-4 substitutions and CagA seropositivity with gastritis and precancerous lesions in a northern Indian population...
  23. pmc Chronic Helicobacter pylori infection with Sydney strain 1 and a newly identified mouse-adapted strain (Sydney strain 2000) in C57BL/6 and BALB/c mice
    Lucinda J Thompson
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Infect Immun 72:4668-79. 2004
    ..However, by 15 months postinfection, SS1-infected C57BL/6 mice had developed more severe gastritis than the SS2000-infected animals...
  24. ncbi Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils
    Takeshi Toyoda
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 125:1786-95. 2009
    ..pylori)-induced NF-kappaB activation in cell culture and chronic gastritis in Mongolian gerbils. In AGS gastric cancer cells, CAPE significantly inhibited H...
  25. ncbi The effect of gender on Helicobacter felis-mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse model
    M Court
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    J Pathol 201:303-11. 2003
    ..model has been extensively used to investigate the importance of host factors in the development of chronic gastritis. The effect of gender in this murine model is unknown...
  26. pmc Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients
    Rui Li
    Bioinformatics Division and Center for Synthetic and Systems Biology, TNLIST Department of Automation, Tsinghua University, Beijing 100084, China
    Sci Rep 3:1543. 2013
    ..By implementing this approach and investigating a group of chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG) patients, we found that with leptin as a biomarker, Cold Syndrome ..
  27. pmc Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection
    Daniel P Barry
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e29046. 2011
    ..pylori infection. CAT2(-/-) mice infected for 4 months exhibited decreased gastritis and increased levels of colonization compared to wild type mice...
  28. pmc Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis
    Dariush Nasrollahzadeh
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 6:e26957. 2011
    ..pylori) in Northern Iran, we performed an endoscopy-room-based validation study...
  29. pmc Local secretory immunoglobulin A and postimmunization gastritis correlate with protection against Helicobacter pylori infection after oral vaccination of mice
    T Goto
    Second Department of Internal Medicine, Oita Medical University, Hasama machi, Oita, Japan
    Infect Immun 67:2531-9. 1999
    ..In protected mice, however, severe gastritis characterized by marked infiltration of inflammation mononuclear cells was noted at 6 weeks after challenge, ..
  30. ncbi Validation and psychometric properties of Chinese version of SF-36 in patients with hypertension, coronary heart diseases, chronic gastritis and peptic ulcer
    Z Yang
    School of Public Health, Guangdong Medical College, Dongguan, China
    Int J Clin Pract 66:991-8. 2012
    ..version of the SF-36 (CSF-36) is rarely used for those patients with hypertension, coronary heart diseases, chronic gastritis and peptic ulcer in China. Therefore, the CSF-36 needs to be validated in patients with chronic diseases.
  31. pmc Detection of p53 mutations in precancerous gastric tissue
    C Morgan
    Human Molecular Pathology Group, Swansea Clinical School, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Br J Cancer 89:1314-9. 2003
    Intestinal-type gastric cancer is preceded by gastritis and intestinal metaplasia. There is uncertainty regarding the stage at which genetic alterations in the p53 gene occur...
  32. ncbi Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..We aimed to clarify the relationship of interleukin (IL)-8 polymorphism with the risk of atrophic gastritis and gastric cancer...
  33. ncbi Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis
    Marco Centanni
    Endocrinology Unit, Department of Experimental Medicine and Pathology, University La Sapienza, Polo Pontino, Latina, Italy
    N Engl J Med 354:1787-95. 2006
    ..We determined whether there is an increased need for thyroxine in patients with euthyroid multinodular goiter and impaired secretion of gastric acid...
  34. ncbi The role of interleukin-17 in the Helicobacter pylori induced infection and immunity
    Shahjahan Kabir
    Academic Research and Information Management, Uppsala, Sweden
    Helicobacter 16:1-8. 2011
    ....
  35. ncbi The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment
    M Stolte
    Department of Pathology, Klinikum Bayreuth, Preuschwitzerstrasse 101, 95445 Bayreuth, Germany
    Can J Gastroenterol 15:591-8. 2001
    In recent years, the importance of the histological diagnosis of gastritis on the basis of routinely obtained antral and corpus biopsies has increased enormously, which is owed not least of all to the discovery of Helicobacter pylori...
  36. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..obtained from patients with different clinical presentations (peptic ulcer, gastric cancer, and atrophic gastritis). The H. pylori isolates examined included 107 strains from Bogota, Colombia, 70 from Houston, Tex...
  37. pmc Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    Gyeong Hoon Kang
    Department of Pathology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1551-6. 2003
    ..Male patients showed higher numbers of methylated genes than females (3.2 vs. 2.1, respectively, P = 0.002). Gastritis samples with marked intestinal metaplasia, showed higher numbers of genes methylated than those without (3.7 vs...
  38. pmc Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia
    Torsten K Roepke
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 5:e11451. 2010
    ..Kcne2(-/-) mice in a pathogen-free environment all exhibit a severe gastric preneoplastic phenotype comprising gastritis cystica profunda, 6-fold increased stomach mass, increased Ki67 and nuclear Cyclin D1 expression, and TFF2- and ..
  39. pmc Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype
    F Sommer
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen Nürnberg, Erlangen, Germany
    Infect Immun 66:5543-6. 1998
    ..T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared...
  40. ncbi MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    J Immunol 187:3578-86. 2011
    ..pylori-induced chronic gastritis and associated gastric preneoplastic pathology...
  41. ncbi Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
    ..Patients with H. pylori gastritis showed significantly higher cathepsin X mRNA (2.5-fold) and protein (1.6-fold) expression than H...
  42. ncbi Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis
    Gyeong Hoon Kang
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, Seoul, Korea
    Lab Invest 83:635-41. 2003
    ..collection of GC (n = 80), gastric adenoma (GA) (n = 79), intestinal metaplasia (IM) (n = 57), and chronic gastritis (CG) (n = 74)...
  43. pmc African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Dig Dis 10:77-84. 2009
    ..and Indian enigmas relate to gastric cancer and peptic ulcers, respectively, and when one takes the patterns of gastritis in the different regions, these enigmas disappear...
  44. pmc Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Jafar Mahdavi
    Department of Odontology Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:573-8. 2002
    ..The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection...
  45. ncbi IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis
    Roberta Caruso
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, University of Rome Tor Vergata, Rome, Italy
    J Immunol 178:5957-65. 2007
    ..These data indicate that IL-21 is overexpressed in Hp-infected gastric mucosa where it could contribute to increased epithelial gelatinase production...
  46. pmc Bacterial microbiota profiling in gastritis without Helicobacter pylori infection or non-steroidal anti-inflammatory drug use
    Xiao Xing Li
    Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 4:e7985. 2009
    ..Helicobacter pylori infection and non-steroidal anti-inflammatory drug (NSAID) use are two main contributors to gastritis and peptic ulcer...
  47. pmc Emerging role of IL-23/IL-17 axis in H pylori-associated pathology
    Roberta Caruso
    World J Gastroenterol 13:5547-51. 2007
    ..In this paper, we will review the available data on the expression and role of IL-23 and IL-17 in H pylori-related gastritis.
  48. ncbi Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice
    Sophie Candon
    Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Immunol 172:2917-24. 2004
    CD4(+) T cells that lead to autoimmune gastritis (AIG) in BALB/c mice are either Th1 or Th2 cells...
  49. pmc Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer
    Steffen Backert
    Department of Medical Microbiology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Infect Immun 72:1043-56. 2004
    ..Here, we have compared cagPAI-dependent in vitro responses in H. pylori isolates obtained from 75 patients with gastritis, peptic ulcer, and gastric cancer (n = 25 in each group)...
  50. ncbi Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis
    Shunji Ishihara
    Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, Izumo, Japan
    J Immunol 173:1406-16. 2004
    ..Helicobacter pylori LPS is one of the major virulence factors for induction of gastritis. We demonstrated in this study the role of MD-2 in TLR4-dependent signaling in H. pylori-associated gastritis...
  51. ncbi Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue
    Katya Gudis
    Third Department of Internal Medicine, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Lab Invest 85:225-36. 2005
    ..patients and consisted of surgical resections of gastric ulcers, or biopsies of gastric ulcers or gastritis. mPGES-1 mRNA and protein expression levels were examined by real-time polymerase chain reaction (PCR) and ..
  52. ncbi Prevalence of silent gastric ulcer, erosions or severe acute gastritis in patients with type 2 diabetes mellitus--a cross-sectional study
    Michael W J Boehme
    Wilhelm Fresenius Klinik Dr Horst Schmidt Kliniken, Department of Internal Medicine, Wiesbaden, Germany
    Hepatogastroenterology 54:643-8. 2007
    ..The aim of the present study was to evaluate the prevalence of silent severe acute gastritis, gastric ulcers or erosions in asymptomatic patients with diabetes mellitus and to determine potential ..
  53. ncbi Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads
    Ratha Korn Vilaichone
    Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani, Thailand
    Helicobacter 9:453-9. 2004
    ..Chinese with gastric cancer or peptic ulcer disease had East Asian genotype, whereas only 40% of Chinese with gastritis had this genotype). Conclusions. Immigration, intermarriage and the variety of H...
  54. ncbi Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis
    Thomas Wultsch
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pain 134:245-53. 2008
    ..Mild gastritis was induced by addition of iodoacetamide (0.1%) to the drinking water for 7 days...
  55. ncbi Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study
    M Asaka
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Helicobacter 6:294-9. 2001
    BACKGROUND: This study evaluated the relationship between Helicobacter pylori infection, atrophic gastritis and intestinal metaplasia in Japan. MATERIALS AND METHODS: This was a multicenter study performed in 21 centers in Japan...
  56. ncbi Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:1443-9. 2007
    ..The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan...
  57. pmc Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner
    Michael J Hornsby
    Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA
    Gastroenterology 134:1049-57. 2008
    ..We used the rhesus macaque model to study the effects of the cag pathogenicity island (cag PAI) on the H pylori host-pathogen interaction...
  58. ncbi Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils
    Satoshi Matsubara
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 310:715-9. 2003
    ..Mongolian gerbils were given GTE in drinking water at the concentrations of 500, 1000, and 2000 ppm for 6 weeks, gastritis and the prevalence of H. pylori-infected animals were suppressed in a dose-dependent manner...
  59. pmc Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis
    Katie L Mason
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Infect Immun 80:150-8. 2012
    ..Disturbance of the gastric bacterial community by cefoperazone alone was not sufficient to cause gastritis, C. albicans colonization was also needed...
  60. ncbi Dual roles of CagA protein in Helicobacterpylori-induced chronic gastritis in mice
    Masahiro Kido
    Department of Gastroenterology and Hepatology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 412:266-72. 2011
    ..In this study, to investigate the roles of CagA in the development of H. pylori-induced chronic gastritis, we used an adoptive-transfer model in which spleen cells from C57BL/6 mice with or without H...
  61. ncbi Usefulness of a serological panel test in the assessment of gastritis in symptomatic children
    Gian Luigi De Angelis
    Department of Paediatrics, University of Parma, Parma, Italy
    Dig Dis 25:206-13. 2007
    Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H...
  62. pmc Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer
    Yvana Cristina Jorge
    Department of Biology, Sao Paulo State University UNESP, Campus de São José do Rio Preto, Rua Cristóvão Colombo 2265, 15054 000 Sao Jose do Rio Preto, SP, Brazil
    Mediators Inflamm 2013:152860. 2013
    ..between the gene and protein expression of annexin-A1 (ANXA1/AnxA1) and galectin-1 (LGALS1/Gal-1) in an inflammatory gastric lesion as chronic gastritis (CG) and gastric adenocarcinoma (GA) and its association with H. pylori infection.
  63. ncbi Role of bacterial strain diversity of Helicobacter pylori in gastric carcinogenesis induced by N-methyl-N-nitrosourea in Mongolian gerbils
    Tomotaro Kawazoe
    Division of Upper Gastroenterology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Helicobacter 12:213-23. 2007
    ..Therefore, we examined whether H. pylori strains introduced to the same host (Mongolian gerbils) differed in carcinogenicity...
  64. ncbi Serum and plasma concentration of oxidant and antioxidants in patients of Helicobacter pylori gastritis and its correlation with gastric cancer
    Shruti S Khanzode
    Department of Medicine, Goverment Medical College, 46, S E Rly Colony, Venkatesh Apartment, Pratap Nagar, NAGPUR 440 022, Maharashtra, India
    Cancer Lett 195:27-31. 2003
    Serum superoxide dismutase, plasma ascorbic acid and lipid peroxidation in H. pylori gastritis and gastric cancer patients were compared with values for age matched healthy subjects...
  65. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
    ..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
  66. pmc Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Gut 53:1244-9. 2004
    ..Gastric intestinal metaplasia (IM) is generally considered to be a precancerous lesion in the gastric carcinogenesis cascade. This study identified the risk factors associated with progression of IM in a randomised control study...
  67. ncbi Gastric mucosal cytokine responses in Helicobacter pylori-infected patients with gastritis and peptic ulcers. Association with inflammatory parameters and bacteria load
    S Holck
    Department of Pathology, Hillerød Hospital, Helsevej 2, DK 3400 Hillerød, Denmark
    FEMS Immunol Med Microbiol 36:175-80. 2003
    ..Furthermore, the study confirms the connection between increase of IL-8 and inflammatory activity in gastric mucosa in H. pylori infection...
  68. ncbi Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of "Candidatus Helicobacter heilmannii"-induced gastritis and gastr
    Akira Suzuki
    Department of Surgery, Shinshu University Hospital, Matsumoto, Japan
    Helicobacter 15:538-48. 2010
    Candidatus Helicobacter heilmannii" induce chronic gastritis, which eventually leads to gastric B-cell type mucosa-associated lymphoid tissue (MALT) lymphoma...
  69. ncbi The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Dengakugakubo, Toyoake 470 1192, Japan
    Int J Mol Med 19:143-8. 2007
    ..We attempted to clarify the relationship between Nrf2 gene polymorphism and chronic gastritis in a Japanese population...
  70. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
    ....
  71. ncbi A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children
    Fabrício Freire de Melo
    Laboratory of Research in Bacteriology, Universidade Federal de Minas Gerais, Av Alfredo Balena, 190, sala 216, 30130 100 Belo Horizonte, Brazil
    Microbes Infect 14:341-7. 2012
    ..In conclusion T(reg) instead of Th17 cell response to H. pylori-infection predominates in children...
  72. pmc A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence
    M S Alam
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Mucosal Immunol 2:232-42. 2009
    ..We studied the role of adenosine in the T-cell-mediated regulation of gastritis and bacterial persistence...
  73. ncbi Expression of beta-defensin 4 is increased in human gastritis
    J M Otte
    Ruhr University, Bochum, Germany
    Eur J Clin Invest 39:126-38. 2009
    ..study aimed to determine the expression of the novel peptides beta-defensin 4 (hBD-4) and RNase 7 in infectious and non-infectious gastritis. Furthermore, pattern recognition receptors and mechanisms of regulation were characterized.
  74. ncbi Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells
    Ali A Akhiani
    Department of Clinical Immunology, University of Goteborg, Goteborg, Sweden
    J Immunol 169:6977-84. 2002
    ..However, IFN-gamma, but not IL-12, was involved in the development of gastritis because IFN-gamma(-/-) (GKO) mice exhibited significantly less inflammation as compared with IL-12(-/-) or wild-..
  75. ncbi Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression
    N Uehara
    Division of Laboratory Diagnosis, Sapporo Medical University School of Medicine, South 1, West 16, Chuo ko, Sapporo 060 8543, Japan
    J Med Microbiol 52:41-5. 2003
    ..pylori completely. The results suggest that hBD-2 may be involved in the pathophysiology of H. pylori-induced gastritis.
  76. ncbi Helicobacter pylori induces macrophage apoptosis by activation of arginase II
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 168:4692-700. 2002
    ..We also demonstrate that arginase II expression is up-regulated in both murine and human H. pylori gastritis tissues, indicating the likely in vivo relevance of our findings...
  77. ncbi Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Kanazawa Medical University, Uchinadamachi, Kanazawa, Ishikawa, Japan
    Eur J Gastroenterol Hepatol 21:613-9. 2009
    ..Here, we examined whether methylation of multiple promoter CpG islands would occur by H. pylori infection and correlate with histological or serological severity of chronic gastritis.
  78. ncbi Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
    Akinori Yanaka
    Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba ken, Tokyo, Japan
    Cancer Prev Res (Phila) 2:353-60. 2009
    ..pylori colonization in mice and improves the sequelae of infection in infected mice and in humans. This treatment seems to enhance chemoprotection of the gastric mucosa against H. pylori-induced oxidative stress...
  79. ncbi Neither gastric topological distribution nor principle virulence genes of Helicobacter pylori contributes to clinical outcomes
    Yan Wing Ho
    Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Republic of Singapore
    World J Gastroenterol 10:3274-7. 2004
    ..The aim of this study is to determine if the gastric topology and genotypic distribution of H pylori were associated with different upper gastrointestinal pathologies in a multiethnic Asian population...
  80. ncbi Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells
    E Suri-Payer
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, SM722, Boston, MA 02115, USA
    J Autoimmun 16:115-23. 2001
    Murine autoimmune gastritis, induced by neonatal thymectomy or the injection of CD25-depleted lymphocytes into nu/nu recipients, is characterized by an inflammatory infiltrate into the gastric mucosa, parietal cell destruction and ..
  81. ncbi Relevance of vacA genotypes of Helicobacter pylori to cagA status and its clinical outcome
    S M Park
    Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea
    Korean J Intern Med 16:8-13. 2001
    ..specimens were obtained from 53 patients with gastric ulcer(GU), 57 with duodenal ulcer (DU) and 26 with chronic gastritis(CG) patients; all patients were infected with Helicobacter pylori...
  82. ncbi The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis
    Toshiro Fukui
    The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    J Gastroenterol 46:456-68. 2011
    ..However, the lack of useful markers has hindered studies of their origin. We explored whether Smad2/3, phosphorylated at specific linker threonine residues (pSmad2/3L-Thr), could serve as a marker for stem cells...
  83. ncbi Topography of chronic active gastritis in Helicobacter pylori-positive Asian populations: age-, gender-, and endoscopic diagnosis-matched study
    Takeshi Matsuhisa
    Department of Gastrointestinal Endoscopy, Tama Nagayama Hospital, Nippon Medical School, 1 7 1 Nagayama, Tama, Tokyo 206 8512, Japan
    J Gastroenterol 39:324-8. 2004
    ..The aim of this study was to compare the degree of corpus-predominant gastritis, which is considered to be one of risk factors of gastric cancer, in Helicobacter pylori-positive Asian adult ..
  84. ncbi Inflammatory gene profiles in gastric mucosa during Helicobacter pylori infection in humans
    Sicheng Wen
    Department of Laboratory Medicine, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden
    J Immunol 172:2595-606. 2004
    ..The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Future studies may help identify gene expression patterns predictive of complications of the infection...
  85. pmc Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study
    Khansa Ben Mansour
    Microbiology laboratory UR04SP08 Rabta University Hospital Tunis, 1007 El Jabbari, Tunisia
    Ann Clin Microbiol Antimicrob 9:22. 2010
    ..The frequency of primary resistance to antibiotics in H. pylori isolates is increasing worldwide. In Tunisia, there are limited data regarding the pattern of H. pylori antibiotic primary resistance...
  86. ncbi Methylation status of CDH1 gene in samples of gastric mucous from Brazilian patients with chronic gastritis infected by Helicobacter pylori
    Erika Kague
    Hemocentro, Faculdade de Medicina, UNESP, Botucatu, SP, Brazil
    Arq Gastroenterol 47:7-12. 2010
    ..Helicobacter pylori(H. pylori) is a class I carcinogen and infect almost 90% of chronic gastritis patients. Some genotypes confer different virulent potential to H...
  87. ncbi Murine models of H. pylori-induced gastritis and gastric adenocarcinoma
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Pathol Res Pract 207:599-607. 2011
    ..practical models have been established for the investigation of the initiation, expansion, and progression of gastritis and gastric carcinoma, for assessing the effects of bacterial, genetic and environmental factors, and for ..
  88. ncbi Characteristics of Helicobacter pylori-induced gastritis and the effect of H. pylori eradication in patients with chronic idiopathic thrombocytopenic purpura
    Takafumi Ando
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Helicobacter 9:443-52. 2004
    ..We investigated the prevalence of H. pylori infection, its virulence profile and the effectiveness of its eradication in patients with ITP...
  89. ncbi Duodenal intraepithelial lymphocytosis with normal villous architecture: common occurrence in H. pylori gastritis
    Lorenzo Memeo
    Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Mod Pathol 18:1134-44. 2005
    ..observed expansions of intraepithelial lymphocytes in duodenal biopsies from patients with Helicobacter pylori gastritis. This study was undertaken to prospectively evaluate, unselected, paired gastric and duodenal biopsies from 50 ..
  90. ncbi Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis
    D Pantoflickova
    Division of Gastroenterology, University Hospital, Lausanne, Switzerland
    Aliment Pharmacol Ther 18:805-13. 2003
    Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori. Fermented milk containing Lj1 (LC1), coadministered with antibiotics had a favourable effect on H. pylori gastritis.
  91. ncbi Characterization of multiple Helicobacter bizzozeronii isolates from a Finnish patient with severe dyspeptic symptoms and chronic active gastritis
    Rauni Kivistö
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    Helicobacter 15:58-66. 2010
    Helicobacter pylori is the primary cause of gastritis and peptic ulceration in humans...
  92. ncbi Presence of iceA1 but not cagA, cagC, cagE, cagF, cagN, cagT, or orf13 genes of Helicobacter pylori is associated with more severe gastric inflammation in Taiwanese
    Shew Meei Sheu
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    J Formos Med Assoc 101:18-23. 2002
    ..This study determined the prevalence of genotypes of the PAI, IS605, and iceA1 in H. pylori strains in Taiwanese and whether these genotypes were related to the type of clinical disease or gastric pathology...
  93. pmc Clinical Relevance of the vacA, iceA, cagA, and flaA genes of Helicobacter pylori strains isolated in Eastern Taiwan
    Chao Chuan Wu
    Department of Surgery, Tzu Chi University, Hualien 970, Taiwan
    J Clin Microbiol 43:2913-5. 2005
    ..of Helicobacter pylori flaA, cagA, vacA, and iceA were determined for DNA isolated from patients with chronic gastritis or peptic ulcer in eastern Taiwan...
  94. ncbi Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice
    Yuko Matsumoto
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Helicobacter 10:407-15. 2005
    ..The ability of IL-10(-/-) mice to eradicate H. pylori has not been demonstrated, possibly due to early sacrifice. Therefore, the long-term effect of enhanced gastritis on H. pylori colonization was determined in IL-10(-/-) mice.
  95. pmc Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 67:4594-602. 1999
    The goal of this study was to evaluate the role of host immunity in gastritis and epithelial damage due to Helicobacter pylori. Splenocytes from H. pylori-infected and uninfected C57BL/6 mice were adoptively transferred to H...
  96. ncbi Association between Helicobacter pylori Infection in gastric cancer, ulcers and gastritis in Iranian patients
    Farideh Siavoshi
    Helicobacter 9:470. 2004
  97. pmc Prevalence and genotypes of Helicobacter pylori in gastric biopsy specimens from patients with gastroduodenal pathologies in the Cukurova Region of Turkey
    Togrul Nagiyev
    Department of Microbiology, Faculty of Medicine, University of Cukurova, Adana, Turkey
    J Clin Microbiol 47:4150-3. 2009
    ..s1c allele, unlike in neighboring regions and countries, was found to be significantly higher in patients with gastritis and/or gastric ulcers (P = 0...
  98. pmc Classification of histological severity of Helicobacter pylori-associated gastritis by confocal laser endomicroscopy
    Peng Wang
    Department of Gastroenterology, Shandong University Qilu Hospital, Jinan 250012, Shandong Province, China
    World J Gastroenterol 16:5203-10. 2010
    To classify the histological severity of Helicobacter pylori (H. pylori) infection-associated gastritis by confocal laser endomicroscopy (CLE).
  99. ncbi Risk prediction of gastric cancer by analysis of aberrant DNA methylation in non-neoplastic gastric epithelium
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake cho, Toyoake, Aichi, Japan
    Digestion 75:54-61. 2007
    ..Promoter DNA methylation is also present in various non-neoplastic tissues including gastric epithelium as age-related phenomenon, suggesting that it occurs early in the process of tumorigenesis...
  100. pmc Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis
    Nicole Acosta
    Molecular Diagnostics and Bioinformatics Laboratory, Biological Sciences Department, Los Andes University, Carrera 1 18A 10, Bogota, Colombia
    World J Gastroenterol 16:3936-43. 2010
    ..To investigate Helicobacter pylori (H. pylori) CagA diversity and to evaluate the association between protein polymorphisms and the occurrence of gastric pathologies...
  101. ncbi Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma
    Abdussalam A R Ashour
    Laboratory of Molecular Biology, Faculdade de Medicina, Universidade Federal de Minas Gerais, 30130 100, Belo Horizonte, Brazil
    FEMS Immunol Med Microbiol 33:173-8. 2002
    ..vacA s1b-m1 and cagA(+) strains were associated with higher prevalence of peptic ulcer and gastric carcinoma than vacA s2-m2 and cagA(-) ones. In conclusion, cagA and vacA genotyping may have clinical relevance in Brazil...

Research Grants65

  1. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..pylori colonization and gastritis;B) GMac phenotype and function;and C) Adaptive immunity in gastric tissues, splenocytes, and lymphocytes. 2...
  2. THE ROLE OF CELL SHAPE AND CELL WALL IN HELICOBACTER PYLORI PATHOGENESIS
    NINA REDA SALAMA; Fiscal Year: 2010
    ..pylori is a helical bacterium that colonizes the human stomach causing clinical outcomes ranging from mild gastritis to peptic ulcer and gastric cancer. Descriptions of H...
  3. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..in mice restores L-Arg uptake, macrophage NO production, and cytokine balance, resulting in reduction in both gastritis and H. pylori colonization. H...
  4. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..rodentium. However, eotaxin-1 is not increased in mouse Helicobacter pylori-induced gastritis tissues, indicating that this is not a non specific component of inflammation...
  5. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The gastric carcinogen Helicobacter pylori induces superficial gastritis and transient hypochlorhydria which may progress to atrophic gastritis and eventually gastric adenocarcinoma...
  6. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Infection with pathogenic Salmonella strains causes symptoms ranging from gastritis to potentially fatal systemic disease such as Typhoid Fever...
  7. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..The vast majority of gastric cancer evolves in the stomach in the setting of chronic atrophic gastritis usually in association with Helicobacter pylori infection. While the role of H...
  8. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..pylori infection and associated pathology. H. pylori is a Gram-negative bacterium that causes chronic gastritis, peptic ulcers, and gastric cancer...
  9. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..pathogen that chronically infects over 50% of the world's population and causes diseases ranging from gastritis to gastric cancer...
  10. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
    ..Infection with this gram negative bacterium results in significant gastroduodenal diseases that include chronic gastritis, ulcers and cancer...
  11. Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pylori
    MARION SHONN DORER; Fiscal Year: 2010
    ..Inflammation caused by H. pylori puts the infected population at increased risk for chronic gastritis, peptic ulcer disease, and gastric cancers, the second leading cause of cancer-related deaths in the world [2]...
  12. 16th international conference on Campylobacter, Helicobacter and related organism
    Irving Nachamkin; Fiscal Year: 2011
    ..The association of H. pylori with gastritis, peptic ulcers and gastric carcinoma is now universally recognized...
  13. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012
    ..provided by applicant): Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  14. Immune Evasion by H. pylori
    Victor E Reyes; Fiscal Year: 2010
    ..This bacterium is a causal agent for chronic gastritis, duodenal and gastric ulcers. Hp is also linked to gastric cancer...
  15. Mechanism of H. pylori-induced risk reduction for inflammatory bowel disease
    Jay Luther; Fiscal Year: 2009
    ..H. pylori infection has clearly been linked to the development of gastritis, peptic ulcer disease and certain gastric malignancies, yet close to 90% of infected individuals will remain ..
  16. Anti-inflammatory actions of bone morphogenetic protein signaling in the stomach
    Andrea Todisco; Fiscal Year: 2013
    ..morphological and functional features of the gastric mucosa, leading to the development of diseases such as gastritis, peptic ulcer and gastric cancer...
  17. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2013
    ..type, which follows a temporal sequence of pathologic changes that leads from chronic non-atrophic gastritis, to atrophic gastritis, intestinal metaplasia, dysplasia, and finally gastric adenocarcinoma...
  18. H. pylori ancestral haplotype a gastric cancer risk determinant in Latin America
    Douglas Morgan; Fiscal Year: 2013
    ..pylori associated cancer risk, based upon studies of subjects with chronic gastritis from high and low incidence regions of Colombia...
  19. Barrier Dysfunction in Severe Surgical Diseases
    Douglas J Turner; Fiscal Year: 2012
    ..contribute the pathophysiology of several diseases such as postsurgical healing, trauma, stress ulceration and gastritis, and inflammatory bowel disease among many others...
  20. Urease Activity and Nitrogen Assimilation in Helicobacter pylori
    ERICA FRANCESCA MILLER; Fiscal Year: 2012
    ..Discovered in the early 1980's, Helicobacter pylori is a common cause of peptic and duodenal ulcers, gastritis, anemia, and certain gastric cancers...
  21. Pathways and pathogens affecting gastric epithelial repair in vivo
    Marshall H Montrose; Fiscal Year: 2013
    ..Our work focusing on the repair of focal lesions in vivo will be extrapolated to experiments evaluating gastritis and ulceration to enhance relevance to gastric pathologies observed clinically...
  22. Mechanisms of Gastric Mucous Cell Metaplasia
    JAMES RICHARD GOLDENRING; Fiscal Year: 2012
    ..The loss of parietal cells (oxyntic atrophy) is a critical step in the pathogenesis of chronic gastritis and gastric cancer...
  23. Tilting the balance in cancer immunotherapy and autoimmunity
    Wei Zen Wei; Fiscal Year: 2010
    ..of spontaneous tumorigenesis and metastasis will be measured and the development of EAT and autoimmune gastritis will be the indicators of untoward autoimmunity...
  24. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..pylori will have clinical sequelae, while the remainder will have only asymptomatic gastritis, there is considerable interest in understanding host factors that are associated with disease...
  25. GNOTOBIOTIC TRANSGENIC MODELS OF THE GASTRIC ECOSYSTEM
    JEFFREY IVAN GORDON; Fiscal Year: 2010
    ..A subset of Hp-infected hosts develops chronic atrophic gastritis (ChAG), characterized in part by loss of acid-producing parietal cells (PCs)...
  26. Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori
    Markus Stein; Fiscal Year: 2013
    ..provided by applicant): Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori Gastritis and gastric carcinoma, the second leading cause of cancer-related deaths in the world, have been linked to ..
  27. A Novel Wireless Capsule Camera with High Resolution Optically Unwrapped 360-Degr
    Jason Geng; Fiscal Year: 2010
    ..g. hiatal hernia, gastritis, ulcers, polyps, stomach/colon cancer...
  28. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..a helical rod shaped bacterium that colonizes the human stomach causing clinical outcomes that range from mild gastritis to peptic ulcer and gastric cancers. Most descriptions of H...
  29. Role of Helicobacter Pylori in the Pathogenesis of Childhood Asthma
    Jay V Solnick; Fiscal Year: 2012
    ..provided by applicant): Helicobacter pylori commonly infects the human stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. The prevalence of H...
  30. Role of Dendritic Cells in H pylori-induced Treg-mediated Host Immune Tolerance
    John Y Kao; Fiscal Year: 2013
    ..H. pylori is a gastric pathogen able to cause severe chronic gastritis and ulcers in <15% of infected individuals, but the majority developed a mild gastritis without symptoms...
  31. NF-kB Signaling and H. Pylori-induced Gastric Disease
    Lin Feng Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): H. pylori infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. H...
  32. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..by Helicobacter pylori, which chronically colonizes over half of the world's human population and causes gastritis, ulcer disease, gastric carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma...
  33. Zona Pellucida: Immunopathologic Study
    Kenneth S K Tung; Fiscal Year: 2013
    ..Our study will define many Treg functions relevant to many common human diseases such as: pemphigus vulgaris, IC disease (SLE), Sjogren's syndrome, APS1, gastritis, and male and female idiopathic infertility due to gonadal failure.
  34. Role of adhesin-receptor interaction in H. pylori-induced gastric carcinogenesis
    JENNIFER MCMILLAN NOTO; Fiscal Year: 2012
    ..and that these interactions activate host cell signaling pathways that are involved in the progression of gastritis to gastric adenocarcinoma. Therefore, the Specific Aims of this application are (1) to define H...
  35. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    Jay V Solnick; Fiscal Year: 2013
    ..provided by applicant): Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  36. Alcohol Injury Healing, Cytoprotection and Survivin
    Michael Jones; Fiscal Year: 2009
    ..especially in combination with nonsteroidal anti-inflammatory agents, is the most frequent cause of erosive gastritis and upper gastrointestinal (Gl) bleeding...
  37. Cellular Decisions of Differentiation in the GI Tract
    Juanita L Merchant; Fiscal Year: 2013
    ..Subproject #2 entitled "Role of Hedgehog signaling in chronic gastritis and metaplasia" will examine the role of chronic inflammation, specifically proinflammatory cytokines in ..
  38. Helicobacter Pylori-Specific Regulatory T Cells that Limit the Host Response
    Thomas G Blanchard; Fiscal Year: 2010
    ..pylori) colonizes the human gastric mucosa and plays an etiologic role in the development of gastritis, peptic ulcers, and gastric cancer...
  39. The role of Hedgehog Signaling in gastric tissue homeostasis and disease
    Yana Zavros; Fiscal Year: 2013
    ..pylori-induced gastritis has not been investigated. Our long-term goal is to understand the pathogenesis of gastric cancer...
  40. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
    ..Serum pepsinogen and gastrin levels will be used as indicators of atrophic gastritis, and inability to secrete acid...
  41. Dendritic Cell-Epithelial Cell Crosstalk in Human H. pylori Gastritis
    Diane Bimczok; Fiscal Year: 2013
    ..pylori gastritis, i.e., gastric atrophy and neoplasia...
  42. Regulation of Intestinal Epithelial Restitution
    Jian Ying Wang; Fiscal Year: 2013
    ..Various acute GI mucosal injury and gastritis are much more common at our VA patients than those observed in the general public...
  43. GASTRIC ACID SECRETION AND BUFFER CONTENT AFTER EATING
    Mark Feldman; Fiscal Year: 1991
    ..g. espphagitis, gastritis). The economic impact of acid-peptic diseases is tremendous...
  44. Adaptive immune mechanism in acute H. pylori infection
    John Kao; Fiscal Year: 2009
    ..pylori. 3. Determine the functional significance of DCs in H. pylori gastritis. Transgenic mice with diphtheria toxin-sensitive DCs will be used to assess the effect of transient DC depletion ..
  45. Regulatory Mechanisms of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2013
    ..pylori chronically colonizes over half of the world's human population and causes diseases such as gastritis, ulcer disease and gastric carcinoma. H...
  46. Transcriptional regulation of H. pylori-mediated gastric inflammation and cancer
    Lin Feng Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): H. pylori infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of H...
  47. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some...
  48. The role of Th17 cytokines in H.pylori infection
    HOLLY MARIE SCOTT ALGOOD; Fiscal Year: 2013
    ..pylori infection and gastritis. We will (1) investigate the role of IL-17 and IL-22 cytokines in stimulating gastric epithelial cell expression ..
  49. Immunobiology and Prevention of H. pylori Disease
    Phillip Smith; Fiscal Year: 2009
    Worldwide, H. pylori is the leading cause of gastritis, peptic ulceration and gastric malignancy. In developing countries, such as Chile, 60-80% of children are infected with H. pylori, but they rarely develop ulceration...
  50. Salivary Biomarkers for Oral Cancer in Lichen Planus Patients
    Yi Shing Lisa Cheng; Fiscal Year: 2010
    ..g., detecting gastro-intestinal cancers in patients with chronic gastritis or inflammatory bowel diseases)...
  51. Inhibition of Treg function to cure persistent H. pylori infection
    Peter B Ernst; Fiscal Year: 2013
    ..It is the persistence of this infection that leads to the sequence of events that cause gastritis, gastroduodenal ulceration, gastric cancer and lymphoma. Studies of the epidemiology of H...
  52. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    ..The presence of C. pyloridis in the stomach has been associated with peptic ulcer disease, non-ulcer dyspepsia and gastritis. Detection of the organism by either bacterial culture or histologic examination has required invasive ..
  53. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    ..human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
  54. BACTERIAL INDUCED COLITIS IN HLA-B27 RATS
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..Our hypothesis is that chronic colitis and gastritis is the result of an overly aggressive immune response to luminal bacteria in a genetically susceptible host...
  55. Risk factors for gastric disease in pediatric H. pylori
    Benjamin Gold; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Helicobacter pylori (Hp) is a major cause of chronic-active gastritis, primary duodenal ulcers and strongly linked to gastric cancer. Most Hp infections worldwide are acquired in childhood...
  56. H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES
    Douglas Berg; Fiscal Year: 2003
    ..It is the major cause of severe gastritis and peptic ulcers, and a risk factor for gastric cancer, although most infections are asymptomatic...
  57. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
    ..incidence in developing countries, is preceded by a sequence of histologic changes including chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and dysplasia...
  58. HOST RESPONSE TO HELICOBACTER PYLORI INFECTION
    Pelayo Correa; Fiscal Year: 2000
    b>Gastritis due to Helicobacter Pylori is the most common chronic infection in the world today. It has been classified by IARC (WHO) as a Class I human carcinogen...
  59. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..Clinical and epidemiologic studies suggest that the development of atrophic gastritis intestinal metaplasia and dysplasia represent essential steps in the cascade of events leading to gastric cancer...
  60. Asymmetric Synthesis of Exiguaquinol and Analogs for Biological Testing
    Gregg Schwarzwalder; Fiscal Year: 2013
    ..H. pylori is a pathognic bacterium known to cause prolonged gastritis and sharply increased risks for gastric cancer and the MurI enzyme is critical to cell wall biosynthesis...
  61. A Novel In-Vivo Capsule Camera with High Resolution Optically Unwarpped 360-Degre
    Jason Geng; Fiscal Year: 2007
    ..g. hiatal hernia, gastritis, ulcers, polyps, stomach/colon cancer...
  62. Molecular causes and fitness consequences of complex trait variation
    STORRS THOMAS MITCHELL-OLDS; Fiscal Year: 2013
    ..In addition, these experiments examine the genetics of glucosinolates, which are a focus of biomedical research due to their role in prevention of many forms of cancer, as well as gastritis attributable to Helicobacter pylori.
  63. H.pylori arginase modulation of ulcers and cancer
    David McGee; Fiscal Year: 2007
    Helicobacter pylori infects approximately 50% of the human population, causing severe gastric diseases including gastritis, peptic ulcers, and gastric cancer. H...
  64. MUCOSAL IMMUNOLOGY OF HELICOBACTER INDUCED GASTRITIS
    Steven Czinn; Fiscal Year: 2007
    Helicobacter pylori (H. pylori) is a major cause of chronic active gastritis, primary peptic ulcer disease, and is strongly linked to gastric cancer. Individuals infected with H...
  65. ACID INDUCIBLE RESPONSES IN H PYLORI
    Catherine McGowan; Fiscal Year: 2003
    ..pylori are curved Gram-negative bacteria that are now recognized as the cause of chronic superficial gastritis in humans, and this organism plays an important etiologic role in the pathogenesis of peptic ulcer disease and ..