stomach neoplasms

Summary

Summary: Tumors or cancer of the STOMACH.

Top Publications

  1. doi Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    Yung Jue Bang
    Seoul National University College of Medicine, Seoul, South Korea
    Lancet 376:687-97. 2010
  2. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
  3. ncbi Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    David Cunningham
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    N Engl J Med 355:11-20. 2006
  4. doi Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study
    Atsushi Ohtsu
    National Cancer Center, Hospital East, Kashiwa, Chiba, Japan
    J Clin Oncol 29:3968-76. 2011
  5. ncbi Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    J S Macdonald
    St Vincent's Comprehensive Cancer Center, New York, USA
    N Engl J Med 345:725-30. 2001
  6. pmc Epidemiology of gastric cancer
    Katherine D Crew
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States
    World J Gastroenterol 12:354-62. 2006
  7. pmc Circulating microRNAs in plasma of patients with gastric cancers
    M Tsujiura
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachihirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Br J Cancer 102:1174-9. 2010
  8. doi Gastric cancer
    Henk H Hartgrink
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Lancet 374:477-90. 2009
  9. doi E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Cell 13:272-86. 2008
  10. ncbi S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
    Wasaburo Koizumi
    Kitasato University School of Medicine, Sagamihara, Japan
    Lancet Oncol 9:215-21. 2008

Research Grants

Detail Information

Publications267 found, 100 shown here

  1. doi Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    Yung Jue Bang
    Seoul National University College of Medicine, Seoul, South Korea
    Lancet 376:687-97. 2010
    ....
  2. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
    ..Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain...
  3. ncbi Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    David Cunningham
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    N Engl J Med 355:11-20. 2006
    ..We assessed whether the addition of a perioperative regimen of ECF to surgery improves outcomes among patients with potentially curable gastric cancer...
  4. doi Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study
    Atsushi Ohtsu
    National Cancer Center, Hospital East, Kashiwa, Chiba, Japan
    J Clin Oncol 29:3968-76. 2011
    ....
  5. ncbi Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    J S Macdonald
    St Vincent's Comprehensive Cancer Center, New York, USA
    N Engl J Med 345:725-30. 2001
    ..CONCLUSIONS: Postoperative chemoradiotherapy should be considered for all patients at high risk for recurrence of adenocarcinoma of the stomach or gastroesophageal junction who have undergone curative resection...
  6. pmc Epidemiology of gastric cancer
    Katherine D Crew
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States
    World J Gastroenterol 12:354-62. 2006
    ..The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention...
  7. pmc Circulating microRNAs in plasma of patients with gastric cancers
    M Tsujiura
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachihirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Br J Cancer 102:1174-9. 2010
    ..We examined plasma microRNA (miRNA) concentrations from patients with gastric cancers (GCs) to assess their clinical application for diagnosing and monitoring diseases...
  8. doi Gastric cancer
    Henk H Hartgrink
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Lancet 374:477-90. 2009
    ....
  9. doi E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Cell 13:272-86. 2008
    ..Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer...
  10. ncbi S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
    Wasaburo Koizumi
    Kitasato University School of Medicine, Sagamihara, Japan
    Lancet Oncol 9:215-21. 2008
    ....
  11. ncbi Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    N Engl J Med 357:1810-20. 2007
    ..Advanced gastric cancer can respond to S-1, an oral fluoropyrimidine. We tested S-1 as adjuvant chemotherapy in patients with curatively resected gastric cancer...
  12. ncbi Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis
    Tetsuya Ueda
    Department of Molecular Virology, Immunology, Ohio State University, Columbus, OH 43210, USA
    Lancet Oncol 11:136-46. 2010
    ..We aimed to assess the relation between microRNA expression and progression and prognosis of gastric cancer...
  13. ncbi Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial
    Ilfet Songun
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Lancet Oncol 11:439-49. 2010
    ..The aim of the study was to assess the effect of D2 compared with D1 surgery on disease recurrence and survival in patients treated with curative intent...
  14. pmc Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer
    Young Kook Kim
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Nucleic Acids Res 37:1672-81. 2009
    ..Our study demonstrates the functional associations between clustered miRNAs and further implicates that effective cancer treatment may require a combinatorial approach to target multiple oncogenic miRNA clusters...
  15. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
    ..This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori...
  16. ncbi Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
    Lorenzo Fuccio
    University of Bologna, Bologna, Italy
    Ann Intern Med 151:121-8. 2009
    ..Helicobacter pylori infection is associated with gastric cancer, but the effect of eradication treatment on gastric cancer risk is not well defined...
  17. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  18. ncbi Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial
    Yung Jue Bang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Lancet 379:315-21. 2012
    ..We investigated the effect on disease-free survival of adjuvant chemotherapy with capecitabine plus oxaliplatin after D2 gastrectomy compared with D2 gastrectomy only in patients with stage II-IIIB gastric cancer...
  19. pmc MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor
    Jun Tie
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, Shaanxi, China
    PLoS Genet 6:e1000879. 2010
    ..Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis...
  20. doi Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report--a phase III multicenter, prospective, randomized Trial (KLASS Trial)
    Hyung Ho Kim
    Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Ann Surg 251:417-20. 2010
    ..The aim of this study was to evaluate the safety of this trial with respect to morbidity and mortality...
  21. doi miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells
    Lin Xia
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    Int J Cancer 123:372-9. 2008
    ..Taken together, our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2...
  22. doi Capecitabine and oxaliplatin for advanced esophagogastric cancer
    David Cunningham
    Royal Marsden Hospital National Health Service Foundation Trust, Surrey and London, United Kingdom
    N Engl J Med 358:36-46. 2008
    ..We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced esophagogastric cancer...
  23. pmc Identification of gastric cancer stem cells using the cell surface marker CD44
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Stem Cells 27:1006-20. 2009
    ..These results support the existence of gastric CSCs and may provide novel approaches to the diagnosis and treatment of gastric cancer...
  24. doi Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
    Kai Wang
    Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, California, USA
    Nat Genet 43:1219-23. 2011
    ..These results reveal the genomic landscape, and highlight the importance of chromatin remodeling, in the molecular taxonomy of gastric cancer...
  25. ncbi Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial
    Jeeyun Lee
    Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam gu, Seoul 135 710 Korea
    J Clin Oncol 30:268-73. 2012
    ..This trial was designed to compare postoperative treatment with capecitabine plus cisplatin (XP) versus XP plus radiotherapy with capecitabine (XP/XRT/XP)...
  26. doi Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target
    Jeeyun Lee
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Oncol Rep 25:1517-24. 2011
    ..However, the predictive role of MET amplification for treatment response should be further explored in upcoming clinical trials...
  27. pmc Incidence and mortality of gastric cancer in China
    Ling Yang
    National Office for Cancer Prevention and Control, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China
    World J Gastroenterol 12:17-20. 2006
    ....
  28. doi Assessment of a HER2 scoring system for gastric cancer: results from a validation study
    M Hofmann
    Institute of Pathology, Klinikum Kassel, Kassel, Germany
    Histopathology 52:797-805. 2008
    ..The aim was to establish a HER2 scoring system for gastric cancer to identify suitable patients for enrollment in a trial of trastuzumab (Herceptin) in advanced metastatic gastric cancer...
  29. pmc Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
    P Malfertheiner
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Gut 56:772-81. 2007
    ..Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000...
  30. ncbi Altered expression of MiR-148a and MiR-152 in gastrointestinal cancers and its clinical significance
    Yue Chen
    Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, People s Republic of China
    J Gastrointest Surg 14:1170-9. 2010
    ..MicroRNAs are endogenous small noncoding RNAs that aberrantly expressed in various carcinomas. MiR-148a and miR-152, which have the same "seed region", have not been comprehensively investigated in gastrointestinal cancers...
  31. pmc A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan
    Seigo Kitano
    Department of Surgery I, Oita University Faculty of Medicine, Yufu, Oita, Japan
    Ann Surg 245:68-72. 2007
    ..We conducted a retrospective, multicenter study of a large series of patients in Japan to evaluate the short- and long-term outcomes of laparoscopic gastrectomy for early gastric cancer (EGC)...
  32. doi MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin
    Tao Liu
    Tianjin Life Science Research Center, Tianjin Medical University, No 22, Qi Xiang Tai Road, Tianjin 300070, PR China
    Cancer Lett 273:233-42. 2009
    ..Down-regulation of prohibitin by miR-27a may explain why suppression of miR-27a can inhibit gastric cancer cell growth, further supporting that miR-27a functions as an oncogene...
  33. ncbi HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target
    C Gravalos
    Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain
    Ann Oncol 19:1523-9. 2008
    ..This review summarizes the rationale, preclinical evidence, retrospective clinical analyses, and the interim clinical data pertaining HER2 therapies in gastric cancer...
  34. doi Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer
    Mitsuru Sasako
    Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Clin Oncol 29:4387-93. 2011
    ..The results were therefore opened at the recommendation of an independent data and safety monitoring committee. We report 5-year follow-up data on patients enrolled onto the ACTS-GC study...
  35. ncbi Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    M Tanner
    Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN 33101 Tampere, Finland
    Ann Oncol 16:273-8. 2005
    ..HER-2/neu gene amplification has predictive value in breast cancer patients responding to trastuzumab. We wanted to investigate the frequency and clinical significance of HER-2/neu amplification in gastric carcinoma...
  36. ncbi Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    Markku Miettinen
    Departments of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:52-68. 2005
    ..The above results may be helpful for setting the criteria for adjuvant treatment such as Gleevec...
  37. pmc Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer
    Ming Yang Song
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, People s Republic of China
    PLoS ONE 7:e33608. 2012
    ..To investigate the potential of serum miRNAs as biomarkers for early detection of gastric cancer (GC), a population-based study was conducted in Linqu, a high-risk area of GC in China...
  38. doi Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis
    HuiPing Xue
    Department of Gastroenterology, Shanghai Institute of Gastrointestinal Diseases, Shanghai, China
    J Gastroenterol Hepatol 25:1604-17. 2010
    ....
  39. doi Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
    Hiromi Sakamoto
    Nat Genet 40:730-40. 2008
    ..90, 95% CI = 1.56-2.33, P = 8.01 x 10(-11)). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer...
  40. pmc MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation
    Yong Xi Song
    Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City 110001, China
    Mol Cancer 10:1. 2011
    ..The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in gastric cancer...
  41. ncbi Epstein-Barr virus: 40 years on
    Lawrence S Young
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Cancer 4:757-68. 2004
    ..Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours...
  42. doi MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta
    Yoshiyuki Tsukamoto
    Department of Molecular Pathology, Faculty of Medicine and Institute of Scientific Research, Oita University, Oita, Japan
    Cancer Res 70:2339-49. 2010
    ..Taken together, we propose that miR-375 is a candidate tumor suppressor miRNA in gastric carcinoma...
  43. doi Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial
    Jaffer A Ajani
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, TX 77030, USA
    J Clin Oncol 28:1547-53. 2010
    ..Patients with advanced gastric or gastroesophageal adenocarcinoma need more efficacious and safer treatments than established today. S-1, a contemporary oral fluoropyrimidine, can provide that advantage...
  44. ncbi Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    JAMA 291:187-94. 2004
    ..Although chronic Helicobacter pylori infection is associated with gastric cancer, the effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is unknown...
  45. ncbi Molecular-pathological prognostic factors of gastric cancer: a review
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Gastric Cancer 8:86-94. 2005
    ..A combination of these examinations can not only foretell a patient's prognosis but can also give information directly connected with personalized cancer medicine and prevention...
  46. ncbi Screening for gastric cancer in Asia: current evidence and practice
    Wai K Leung
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Lancet Oncol 9:279-87. 2008
    ..At present, there is a paucity of quality data from Asia to lend support for screening for gastric cancer...
  47. ncbi Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues
    Junming Guo
    Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China
    J Gastroenterol Hepatol 24:652-7. 2009
    ..MicroRNAs (miRNAs) play important roles in carcinogenesis. The global miRNA expression profile of gastric cancer has not been reported. The purpose of the present study was to determine the miRNA expression profile of gastric cancer...
  48. pmc Helicobacter pylori and gastric cancer: factors that modulate disease risk
    Lydia E Wroblewski
    Division of Gastroenterology, Vanderbilt University School of Medicine, 2215 Garland Ave, 1030C MRB IV, Nashville, TN 37232 2279, USA
    Clin Microbiol Rev 23:713-39. 2010
    ..Since H. pylori inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes...
  49. doi Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome
    Maria D Begnami
    Department of Pathology, Hospital A C Camargo, Rua Professor Antonio Prudente 211, Liberdade, Sa Paulo, Brazil
    J Clin Oncol 29:3030-6. 2011
    ..The effect of HER3 or HER4 expression in GC has not been sufficiently studied. In this study, we explored the gene and protein expression of the HER family in GC to establish new potential prognostic factors...
  50. pmc MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    Jochen K Lennerz
    Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 29:4803-10. 2011
    ..We examined a GEC cohort with follow-up and reported the clinical response of four additional patients with MET-amplified tumors to the small molecule inhibitor crizotinib as part of an expanded phase I cohort study...
  51. doi Survival prediction of gastric cancer by a seven-microRNA signature
    Xiaohua Li
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 17 Changle Western Road, Xi an, China
    Gut 59:579-85. 2010
    ..No study has evaluated the association between miRNA expression patterns and gastric cancer prognosis. In this study, we developed a seven-miRNA signature that is closely associated with survival of patients with gastric cancer...
  52. ncbi Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  53. doi Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction
    Michael Stahl
    Department of Medical Oncology and Hematology, Kliniken Essen Mitte, Henricistr 92, D 45136 Essen, Germany
    J Clin Oncol 27:851-6. 2009
    ..Preoperative chemotherapy is an accepted standard in the treatment of localized esophagogastric adenocarcinoma. Adding radiation therapy to preoperative chemotherapy appears promising, but its definitive value remains unknown...
  54. ncbi The prevalence of Th17 cells in patients with gastric cancer
    Bin Zhang
    Department of General Surgery, Changhai Hospital, The Second Military Medical University, No 168, Changhai Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 374:533-7. 2008
    ..The results indicate that Th17 cells may contribute to gastric cancer pathogenesis...
  55. ncbi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  56. ncbi Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer
    Hong Mei Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Kaeshin dong, Hungdok gu, Cheongju Si, Chungbuk 361 763, Republic of Korea
    World J Gastroenterol 11:3834-41. 2005
    ..The purpose of this study was to investigate the effects of environmental factors, genetic polymorphisms of major metabolic enzymes, and microsatellite instability on hypermethylation of the promoter of the hMLH1 gene in gastric cancer...
  57. doi miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3
    Xiaohua Li
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an 710032, China
    Mol Cancer Res 9:824-33. 2011
    ..These findings indicate a new regulatory mode, namely, specific miRNA, which is activated by its upstream transcription factor, could suppress its direct targets and lead to tumor invasion and metastasis...
  58. doi X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis
    HuiPing Xue
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Gastrointestinal Diseases, School of Medicine, Shanghai Jiaotong University, People s Republic of China
    Am J Epidemiol 173:363-75. 2011
    ..The Arg399Gln SNP is not associated with the cardia type of gastric cancer. Evidently, the heterogeneity regarding the Arg399Gln SNP across studies is not explained by ethnicity, genotyping technique, sample size, or date of publication...
  59. ncbi Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer
    Toshihiko Doi
    National Cancer Center Hospital East, 5 1, Kashiwanoha 6 chome, Kashiwa shi, Chiba 277 8577, Japan
    J Clin Oncol 28:1904-10. 2010
    ..Adverse events are consistent with the reported safety profile of everolimus. These results warrant further evaluation in patients with advanced gastric cancer...
  60. ncbi Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data
    Anna D Wagner
    First Department of Medicine, Coordinating Centre for Clinical Trials, and Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Clin Oncol 24:2903-9. 2006
    ..This systematic review and meta-analysis were performed to assess the efficacy and tolerability of chemotherapy in patients with advanced gastric cancer...
  61. doi Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma
    Min A Kim
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Histopathology 54:442-51. 2009
    ..EMT is known to be involved in the progression and metastasis of various cancers. The aim was to evaluate the expression of EMT-related proteins in gastric carcinoma (GC)...
  62. doi Epidemiology of stomach cancer
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Methods Mol Biol 472:467-77. 2009
    ..Future epidemiologic research should pay particular attention to differentiation of stomach cancer epidemiology by subsite, and to exploration of potential interactions between H. pylori infection, genetic, and environmental factors...
  63. ncbi Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas
    Jing Zhao
    Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, No 1 Hospital of China Medical University, Shenyang, Liaoning Province, China
    Histol Histopathol 26:1111-20. 2011
    ..Our findings also demonstrated that combined detection of these two tumor-specific biomarkers in gastric carcinomas can provide additional efficacy in predicting the patients' outcomes...
  64. ncbi Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    N Murata-Kamiya
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 26:4617-26. 2007
    ..pylori CagA plays an important role in the development of intestinal metaplasia, a premalignant transdifferentiation of gastric epithelial cells from which intestinal-type gastric adenocarcinoma arises...
  65. pmc Sequential expression of putative stem cell markers in gastric carcinogenesis
    T Wang
    Cancer Science Institute, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Cancer 105:658-65. 2011
    ..Gastric carcinogenesis has been well documented in the step-wise histopathological model, known as Correa pathway. Several biomarkers including CD44, Musashi-1 and CD133 have been reported as putative stem cell (PSC) markers...
  66. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
    ..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...
  67. doi Correlation between genomic alterations assessed by array comparative genomic hybridization, prognostically informative histologic subtype, stage, and patient survival in gastric cancer
    Elena Rossi
    Biology and Medical Genetics, University of Pavia, 27100 Pavia, Italy
    Hum Pathol 42:1937-45. 2011
    ..We conclude that genome-wide array comparative genomic hybridization of gastric cancer contributes prognostically relevant information providing a genetic background for histologic grading...
  68. doi Targeted HER2 treatment in advanced gastric cancer
    Jan Trøst Jørgensen
    Dx Rx Institute, Baunevaenget 76, DK 3480 Fredensborg, Denmark
    Oncology 78:26-33. 2010
    ....
  69. doi A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis
    Rui Liu
    Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 210008, China
    Eur J Cancer 47:784-91. 2011
    ..The purpose of present study was to identify a serum microRNA (miRNA) expression profile that can serve as a novel diagnostic biomarker for GC detection and to assess its clinical applications in monitoring disease progression...
  70. ncbi Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer
    Emel Canbay
    General Surgery, Basaksehir State Hospital, Basaksehir, Istanbul, 34230, Turkey
    Anticancer Res 30:1359-64. 2010
    ..In this study, we examined the polymorphisms of six DNA repair genes: APE1, HOGG1, XRCC1, XRCC3, XPD, and XPG in patients with gastric cancer (GC)...
  71. pmc Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group
    A Cuschieri
    University Department of Surgery, Ninewells Hospital and Medical School, Dundee, UK
    Br J Cancer 79:1522-30. 1999
    ..However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial...
  72. pmc Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients
    J D Barros-Silva
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Br J Cancer 100:487-93. 2009
    ....
  73. pmc Endoscopic mucosal resection for treatment of early gastric cancer
    H Ono
    Department of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gut 48:225-9. 2001
    ..Bleeding and perforation (5%) were two major complications of EMR but there were no treatment related deaths. CONCLUSION: In our experience, EMR allows us to perform less invasive treatment without sacrificing the possibility of cure...
  74. doi Molecular basis of therapeutic approaches to gastric cancer
    Kaichun Wu
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Gastroenterol Hepatol 24:37-41. 2009
    ..Using HLA-A-matched allogeneic gastric cancer cells to induce tumor-specific cytotoxic T lymphocytes appeared to be an alternative option of immunotherapy for gastric cancer...
  75. doi HER-2 amplification is highly homogenous in gastric cancer
    Andreas H Marx
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany
    Hum Pathol 40:769-77. 2009
    ..The high level of HER-2 amplification in combination with the homogeneity of its expression in primary and metastatic tumors argues for a possible therapeutic utility of trastuzumab in HER-2-amplified gastric adenocarcinomas...
  76. pmc Age-specific trends in incidence of noncardia gastric cancer in US adults
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    JAMA 303:1723-8. 2010
    ..For the last 50 years, overall age-standardized incidence rates for noncardia gastric cancer have steadily declined in most populations. However, overall rates are summary measures that may obscure important age-specific trends...
  77. doi HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series
    Heike Grabsch
    Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Cell Oncol 32:57-65. 2010
    ..Existing data on HER2 expression and its clinical relevance in GC are still limited and controversial...
  78. ncbi DNA microarray analysis of the correlation between gene expression patterns and acquired resistance to 5-FU/cisplatin in gastric cancer
    Hark Kyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    Biochem Biophys Res Commun 316:781-9. 2004
    ..These exploratory data demonstrate that the gene expression profiles differ between chemosensitive and refractory state gastric cancer biopsy samples...
  79. doi Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome
    Devasis Chatterjee
    Department of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Clin Cancer Res 14:2994-3001. 2008
    ..We examined the expression patterns of RKIP and STAT3 with regard to human gastric cancer, predicting that elevated RKIP status may favor clinical outcome...
  80. pmc Oncogenic pathway combinations predict clinical prognosis in gastric cancer
    Chia Huey Ooi
    Duke NUS Graduate Medical School, Singapore
    PLoS Genet 5:e1000676. 2009
    ..Predicting pathway activity by expression signatures thus permits the study of multiple cancer-related pathways interacting simultaneously in primary cancers, at a scale not currently achievable by other platforms...
  81. doi Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial
    Y K Kang
    Division of Oncology, Department of Internal Medicine, Asan Medical Center, Songpa Gu, Seoul, Republic of Korea
    Ann Oncol 20:666-73. 2009
    ..To compare capecitabine/cisplatin with 5-fluorouracil/cisplatin as first-line treatment for advanced gastric cancer (AGC)...
  82. doi Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Via Cosimo il Vecchio 2, 50139 Florence, Italy
    Mutagenesis 25:569-75. 2010
    ..25, P=0.0012). These findings indicate that a complex interaction between host factors such as oxidative stress, antioxidant capacity and efficiency of multiple DNA repair pathways underlies the inter-individual variability in GC risk...
  83. ncbi Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach
    Yun Qing Bai
    Department of Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Lett 176:47-55. 2002
    ..Our results thus suggest that CDX2 and CDX1 may play a role during IM formation and gastric carcinogenesis...
  84. ncbi HER-2/neu amplification is an independent prognostic factor in gastric cancer
    Dong Il Park
    Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Dig Dis Sci 51:1371-9. 2006
    ....
  85. ncbi Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma
    Manish A Shah
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 24:5201-6. 2006
    ..We evaluated the efficacy and safety of the addition of bevacizumab to chemotherapy in the treatment of gastric and gastroesophageal junction (GEJ) adenocarcinoma...
  86. doi Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer
    Y Tsukamoto
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    J Pathol 216:471-82. 2008
    ..Based on these results, we propose that our list of candidate genes may contain novel genes involved in the pathogenesis of advanced gastric cancer...
  87. ncbi Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video)
    T Nakayoshi
    Dept of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Endoscopy 36:1080-4. 2004
    ..In addition, three-dimensional images of microvessels were reconstructed using a laser scanning microscope...
  88. pmc Helicobacter pylori: gastric cancer and beyond
    D Brent Polk
    Department of Pediatrics, University of Southern California, Los Angeles, CA 10027, USA
    Nat Rev Cancer 10:403-14. 2010
    ..pylori-infected human populations at increased risk for stomach cancer but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche...
  89. ncbi Gastric cancer treatment guidelines in Japan
    Toshifusa Nakajima
    Cancer Institute Hospital, 1 37 1 Kamiikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Gastric Cancer 5:1-5. 2002
    ....
  90. ncbi Oncogenic mechanisms of the Helicobacter pylori CagA protein
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Nat Rev Cancer 4:688-94. 2004
    ..Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis...
  91. ncbi International variation
    Donald M Parkin
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Oncogene 23:6329-40. 2004
    ..Information on the burden of disease also has a very important role in the planning and monitoring of programmes of cancer control...
  92. pmc Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran
    F Islami
    Digestive Disease Research Center, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran, Iran
    Br J Cancer 90:1402-6. 2004
    ..Further studies are needed to define more precisely the patterns of upper GI cancer incidence, to test other previously suspected risk factors, and to find new significant risk factors in this high-risk area...
  93. pmc Phase II study of modified docetaxel, cisplatin, and fluorouracil with bevacizumab in patients with metastatic gastroesophageal adenocarcinoma
    Manish A Shah
    Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, and the Weill School of Medicine, Cornell University, New York, NY, USA
    J Clin Oncol 29:868-74. 2011
    ..To evaluate the safety and efficacy of a modified administration schedule of docetaxel, cisplatin, and fluorouracil (mDCF) with bevacizumab in patients with advanced gastroesophageal malignancies...
  94. ncbi Endoscopic resection of early gastric cancer
    Takuji Gotoda
    National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Gastric Cancer 10:1-11. 2007
    ..Endoscopic techniques, indications, pathological assessment, and methods of endoscopic resection of EGC need to be established for carrying out appropriate treatment and for the collation of long-term outcome data...
  95. ncbi Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study
    Franco Roviello
    Dipartimento di Chirurgia Generale ed Oncologica, Universita di Siena, Siena, Italia
    J Surg Oncol 94:275-80; discussion 274. 2006
    ..This study was aimed at evaluating the prognostic significance of the number of metastatic nodes in early gastric cancer (EGC)...
  96. ncbi Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening
    M Dinis-Ribeiro
    Showa University, Tokyo, Japan
    J Med Screen 11:141-7. 2004
    ..To assess the validity of the measurement of pepsinogen I and II as a screening test for gastric cancer and pre-malignant lesions, namely low-grade dysplasia, both in the general population and in selected groups of patients...
  97. pmc CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions
    L A Sicinschi
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Microbiol Infect 16:369-78. 2010
    ..This novel finding may partially explain the difference in GC incidence in these populations...
  98. pmc Phase I study of epirubicin, cisplatin and capecitabine plus matuzumab in previously untreated patients with advanced oesophagogastric cancer
    S Rao
    Department of Medicine, Royal Marsden Hospital, Surrey, UK
    Br J Cancer 99:868-74. 2008
    ..At the doses evaluated in serial skin biopsies, matuzumab decreased phosphorylation of EGFR and MAPK, and increased phosphorylation of STAT-3...
  99. pmc Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing
    Zhi Jiang Zang
    Cellular and Molecular Research, National Cancer Centre, Singapore
    Cancer Res 71:29-39. 2011
    ..The catalog of kinome genetic variants assembled here may broaden our knowledge on kinases and provide useful information on genetic alterations in GC...
  100. ncbi Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
    J B A Crusius
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 19:1894-902. 2008
    ..The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent...
  101. ncbi High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004

Research Grants133 found, 100 shown here

  1. RISK FACTORS FOR STOMACH CANCER--A CASE-CONTROL STUDY
    Hans Olov Adami; Fiscal Year: 1992
    ....
  2. RESPONSE DETERMINANTS IN EGOPHAGEAL AND GASTRIC CANCERS
    Lawrence Leichman; Fiscal Year: 1993
    ..Eventually, neoadjuvant and postoperative adjuvant treatments may be individualized on the basis of whether tumors are innately resistant, acquire resistance or remain sensitive despite this intensive preoperative therapy...
  3. Structure-function analysis of H. pylori VacA
    Timothy L Cover; Fiscal Year: 2010
    ..This research seeks to understand how a bacterial infection can lead to these diseases, and seeks to develop new approaches for the prevention and therapy of stomach cancer and peptic ulcer disease. ..
  4. Structure-function analysis of H. pylori VacA
    Timothy L Cover; Fiscal Year: 2011
    ..This research seeks to understand how a bacterial infection can lead to these diseases, and seeks to develop new approaches for the prevention and therapy of stomach cancer and peptic ulcer disease. ..
  5. Structure-function analysis of H. pylori VacA
    TIMOTHY COVER; Fiscal Year: 2009
    ..This research seeks to understand how a bacterial infection can lead to these diseases, and seeks to develop new approaches for the prevention and therapy of stomach cancer and peptic ulcer disease. ..
  6. Structure-function analysis of H. pylori VacA
    TIMOTHY COVER; Fiscal Year: 2007
    ..This research seeks to understand how a bacterial infection can lead to these diseases, and seeks to develop new approaches for the prevention and therapy of stomach cancer and peptic ulcer disease. [unreadable] [unreadable] [unreadable]..
  7. MULTIMODALITY TREATMENT & CLINICAL-BIOLOGICAL CORRELATES
    David Kelsen; Fiscal Year: 1991
    ..Sophisticated biostatistical techniques will be used to analyze the potential correlations between clinical and laboratory data...
  8. MULTIMODALITY TREATMENT & CLINICAL-BIOLOGICAL CORRELATES
    David Kelsen; Fiscal Year: 1993
    ..Sophisticated biostatistical techniques will be used to analyze the potential correlations between clinical and laboratory data...
  9. Surrogate Biomarkers of Micrometastatic Gastric Cancer
    Adam Smolka; Fiscal Year: 2004
    ..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
  10. Surrogate Biomarkers of Micrometastatic Gastric Cancer
    Adam Smolka; Fiscal Year: 2003
    ..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
  11. Analysis of the H. Pylori cag pathogenicity island
    TIMOTHY COVER; Fiscal Year: 2009
    ..This research seeks to understand how a bacterial infection can lead to these diseases. The long-term goals are to develop effective means for the prevention and treatment of stomach cancer and peptic ulcer disease. ..
  12. Analysis of the H. Pylori cag pathogenicity island
    Timothy L Cover; Fiscal Year: 2010
    ..This research seeks to understand how a bacterial infection can lead to these diseases. The long-term goals are to develop effective means for the prevention and treatment of stomach cancer and peptic ulcer disease. ..
  13. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  14. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2008
    ..b. a study to evaluate the acceptability of hypothetical biomarkers among high risk and average risk individuals and primary health care providers. ..
  15. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2004
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  16. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2009
    ..The findings may also improve risk assessment of health effects of arsenic exposure. ..
  17. Olympus FV1000 Confocal Fluorescence Microscope
    James Goldenring; Fiscal Year: 2007
    ..Confocal fluorescence microscopy, especially in its uses for the study of living cells, holds the key to performing all of these studies. PHS 398/2590 (Rev. 09/04) [unreadable] [unreadable] [unreadable]..
  18. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    JAMES RICHARD GOLDENRING; Fiscal Year: 2010
    ..Loss of proper trafficking can lead to the inadequate barrier function, inappropriate secretion or even to transformation and the development of cancer. ..
  19. Risk factors for site-specific metastasis in esophageal cancer
    JULIAN ABRAMS; Fiscal Year: 2008
    ....
  20. Gastrointestinal Tract X FASEB Conference
    James Goldenring; Fiscal Year: 2003
    ..abstract_text> ..
  21. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    James Goldenring; Fiscal Year: 1999
    ..Since Rab11a and Rab25 are components of general apical recycling systems, insights gained in these investigations may lead to more general concepts governing the control of epithelial cell apical trafficking. ..
  22. Cyclic AMP Mediation of Epithelial Cell Function
    James Goldenring; Fiscal Year: 2005
    ..These studies will allow focused investigation of the spectrum of AKAP35O scaffolding complexes that may regulate intra-Golgi and post-Golgi trafficking in polarized epithelial cells. ..
  23. Pesticide Exposure and DNA Methylation in Pesticide Applicators
    Jennifer Rusiecki; Fiscal Year: 2008
    ....
  24. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2007
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  25. Cyclic AMP Mediation of Epithelial Cell Function
    JAMES RICHARD GOLDENRING; Fiscal Year: 2010
    ....
  26. Rab25 in the Pathogenesis of Ichthyosis Vulgaris
    James Goldenring; Fiscal Year: 2003
    ..In addition, it will provide the first investigations of alterations in membrane recycling in skin diseases. ..
  27. Molecular characteristics of the apical recycling system
    James Goldenring; Fiscal Year: 2006
    ..These studies should provide general insights into the functional relevance of components of the apical recycling system, including cargoes, regulatory protein complexes and signaling systems. ..
  28. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2005
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..
  29. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2008
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  30. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2007
    ..b. a study to evaluate the acceptability of hypothetical biomarkers among high risk and average risk individuals and primary health care providers. ..
  31. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    James Goldenring; Fiscal Year: 2009
    ..Loss of proper trafficking can lead to the inadequate barrier function, inappropriate secretion or even to transformation and the development of cancer. ..
  32. Mechanisms of Gastric Mucous Cell Metaplasia
    James Goldenring; Fiscal Year: 2008
    ..The studies proposed here will utilize animal models to understand the pre-cancerous process and to define possible biomarkers that could be used for screening in humans for risk of gastric cancer. ..
  33. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2006
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  34. Molecular characteristics of the apical recycling system
    James Goldenring; Fiscal Year: 2008
    ..These studies should provide general insights into the functional relevance of components of the apical recycling system, including cargoes, regulatory protein complexes and signaling systems. ..
  35. Molecular characteristics of the apical recycling system
    James Goldenring; Fiscal Year: 2007
    ..These studies should provide general insights into the functional relevance of components of the apical recycling system, including cargoes, regulatory protein complexes and signaling systems. ..
  36. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2002
    ....
  37. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ....
  38. Molecular characteristics of the apical recycling system
    James Goldenring; Fiscal Year: 2009
    ..These studies should provide general insights into the functional relevance of components of the apical recycling system, including cargoes, regulatory protein complexes and signaling systems. ..
  39. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2001
    ....
  40. Mechanisms of Gastric Mucous Cell Metaplasia
    JAMES RICHARD GOLDENRING; Fiscal Year: 2010
    ..The studies proposed here will utilize animal models to understand the pre-cancerous process and to define possible biomarkers that could be used for screening in humans for risk of gastric cancer. ..
  41. CYCLIC AMP AS A MEDIATOR OF PARIETAL CELL SECRETION
    James Goldenring; Fiscal Year: 1999
    ..These investigations will provide important insights into the mechanisms by which epithelial cells in general, and parietal cells specifically, segregate their second messenger-dependent signaling systems. ..
  42. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2003
    ....
  43. Small GTP-binding proteins in gastrointestinal mucosa
    James Goldenring; Fiscal Year: 2005
    ..These studies should allow us to identify the critical components of Rab11acoordinated protein complexes regulating the plasma membrane recycling systems. ..
  44. SURGICAL ONCOLOGY TRAINING GRANT
    James Goldenring; Fiscal Year: 2007
    ..abstract_text> ..
  45. Small GTP-binding proteins in gastrointestinal mucosa
    James Goldenring; Fiscal Year: 2004
    ..These studies should allow us to identify the critical components of Rab11acoordinated protein complexes regulating the plasma membrane recycling systems. ..
  46. Rash from EGFR Inhibitors: Characterization & Palliation of a Symptom Cluster
    Aminah Jatoi; Fiscal Year: 2008
    ..The purpose of this proposal is to better characterize this skin-related symptom cluster from a clinical and basic science standpoint and to test the agent menadione to prevent it all together. ..
  47. CYCLIC AMP AS A MEDIATOR OF PARIETAL CELL SECRETION
    James Goldenring; Fiscal Year: 2000
    ..These investigations will provide important insights into the mechanisms by which epithelial cells in general, and parietal cells specifically, segregate their second messenger-dependent signaling systems. ..
  48. Cyclic AMP Mediation of Epithelial Cell Function
    James Goldenring; Fiscal Year: 2006
    ..These studies will allow focused investigation of the spectrum of AKAP35O scaffolding complexes that may regulate intra-Golgi and post-Golgi trafficking in polarized epithelial cells. ..
  49. Cyclic AMP Mediation of Epithelial Cell Function
    James Goldenring; Fiscal Year: 2003
    ..These studies will allow focused investigation of the spectrum of AKAP35O scaffolding complexes that may regulate intra-Golgi and post-Golgi trafficking in polarized epithelial cells. ..
  50. Cyclic AMP Mediation of Epithelial Cell Function
    James Goldenring; Fiscal Year: 2002
    ..These studies will allow focused investigation of the spectrum of AKAP35O scaffolding complexes that may regulate intra-Golgi and post-Golgi trafficking in polarized epithelial cells. ..
  51. Molecular characteristics of the apical recycling system
    James Goldenring; Fiscal Year: 2009
    ..These studies should provide general insights into the functional relevance of components of the apical recycling system, including cargoes, regulatory protein complexes and signaling systems. ..
  52. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    James Goldenring; Fiscal Year: 2001
    ..Since Rab11a and Rab25 are components of general apical recycling systems, insights gained in these investigations may lead to more general concepts governing the control of epithelial cell apical trafficking. ..
  53. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    James Goldenring; Fiscal Year: 2002
    ..Since Rab11a and Rab25 are components of general apical recycling systems, insights gained in these investigations may lead to more general concepts governing the control of epithelial cell apical trafficking. ..
  54. Small GTP-binding proteins in gastrointestinal mucosa
    James Goldenring; Fiscal Year: 2004
    ..These studies should allow us to identify the critical components of Rab11acoordinated protein complexes regulating the plasma membrane recycling systems. ..
  55. Cyclic AMP Mediation of Epithelial Cell Function
    James Goldenring; Fiscal Year: 2002
    ..These studies will allow focused investigation of the spectrum of AKAP35O scaffolding complexes that may regulate intra-Golgi and post-Golgi trafficking in polarized epithelial cells. ..
  56. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2001
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  57. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2001
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  58. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2000
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  59. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  60. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2002
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  61. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2003
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  62. TRAINING GRANT IN GASTROENTEROLOGY
    Richard Peek; Fiscal Year: 2008
    ..Lay summary: The goal of this training program is to develop scientists with strong commitments to academic biomedical research in the area of digestive diseases. ..
  63. Novel Method of Surveillance in Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2008
    ..This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer. [unreadable] [unreadable] [unreadable]..
  64. TRAINING GRANT IN GASTROENTEROLOGY
    Richard Peek; Fiscal Year: 2008
    ..Lay summary: The goal of this training program is to develop scientists with strong commitments to academic biomedical research in the area of digestive diseases. ..
  65. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2008
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  66. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2007
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..
  67. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2007
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..
  68. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2009
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..
  69. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2008
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..
  70. H. Pylori Relationship to Digestive Diseases and Cancer
    Richard Peek; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: These studies will define bacterial and host factors that influence gastric cancer. Such findings may help to identify H. pylori-infected persons at high risk for gastric cancer, who thereby warrant therapy. ..
  71. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2009
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..
  72. Molecular Markers of Response to Chemoradiation in Localized Esophageal Cancer
    Jaffer Ajani; Fiscal Year: 2008
    ..Our goal is to pave the way for a strategy in the future that will allow administration of effective therapy, improve safety, and preserve the esophagus in some patients. ..
  73. H. Pylori Relationship to Digestive Diseases and Cancer
    Richard M Peek; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: These studies will define bacterial and host factors that influence gastric cancer. Such findings may help to identify H. pylori-infected persons at high risk for gastric cancer, who thereby warrant therapy. ..
  74. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2010
    ....
  75. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  76. Detection and Diagnosis of Pancreatic Cancer
    David Gold; Fiscal Year: 2008
    ..Aim 3. To investigate whether inclusion of other mucin biomarkers can increase diagnostic accuracy through multivariate analyses. ..
  77. Helicobacter pylori and gastrointestinal biology
    Richard M Peek; Fiscal Year: 2010
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..
  78. H. Pylori Relationship to Digestive Diseases and Cancer
    Richard Peek; Fiscal Year: 2008
    ..PUBLIC HEALTH RELEVANCE: These studies will define bacterial and host factors that influence gastric cancer. Such findings may help to identify H. pylori-infected persons at high risk for gastric cancer, who thereby warrant therapy. ..
  79. HPYLORI INDUCED DNA DAMAGE AND IMMUNE DYSREGULATION
    Keith Wilson; Fiscal Year: 2000
    ..The results of these studies will provide new information that will elucidate the central pathogenetic steps of H. pylori disease and will provide potential new targets for intervention and therapy. ..
  80. Molecular Strategies for Gastric Carcinoid Surgery
    Irvin Modlin; Fiscal Year: 2005
    ..A pre-operative determination of the neoplastic ECL cell gene expression relating to gastrin responsiveness will improve the rationale for therapeutic gastric or antral resection. ..
  81. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2005
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  82. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2005
    ....
  83. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  84. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  85. H.Pylori Relationship to Digestive Diseases and Cancer
    Richard Peek; Fiscal Year: 2004
    ..pylori-induced carcinogenesis and facilitate identification of potential therapeutic targets, but may also provide insights into other malignancies that arise within the context of inflammatory states. ..
  86. Molecular Strategies for Gastric Carcinoid Surgery
    Irvin Modlin; Fiscal Year: 2003
    ..A pre-operative determination of the neoplastic ECL cell gene expression relating to gastrin responsiveness will improve the rationale for therapeutic gastric or antral resection. ..
  87. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2003
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  88. iNOS, COX-2, and Arginase in Murine Barrett's Esophagus
    Keith Wilson; Fiscal Year: 2003
    ..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
  89. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  90. MoAbs for the Management of Pancreatic Cancer
    David Gold; Fiscal Year: 2003
    ..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..