Genomes and Genes
Summary: Tumors or cancer of the RECTUM.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications372 found, 100 shown here
- The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detectionSheng Xiang Rao
Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
Eur J Radiol 65:299-303. 2008..To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone...
- A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapyG Lezoche
Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
Surg Endosc 22:352-8. 2008....
- Preoperative versus postoperative chemoradiotherapy for rectal cancerRolf Sauer
Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
N Engl J Med 351:1731-40. 2004..In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer...
- The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinomaKoen C M J Peeters
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Ann Surg 246:693-701. 2007..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
- Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trialDavid Sebag-Montefiore
St James s University Hospital, Leeds, UK
Lancet 373:811-20. 2009..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
- Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapyH Birgisson
Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala, Uppsala, Sweden
Br J Surg 95:206-13. 2008..The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and to determine their relationship to preoperative radiation therapy...
- Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient dataMonique Maas
Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands
Lancet Oncol 11:835-44. 2010..This study established whether patients with pCR have better long-term outcome than do those without pCR...
- Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03Mark S Roh
National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
J Clin Oncol 27:5124-30. 2009..The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma...
- Effective surgical adjuvant therapy for high-risk rectal carcinomaJ E Krook
Duluth Community Clinical Oncology Program, Minn
N Engl J Med 324:709-15. 1991..We designed a combination regimen to optimize the contribution of chemotherapy, decrease recurrence, and improve survival as compared with adjuvant radiation alone...
- Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectumMai Yamauchi
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Gut 61:847-54. 2012..Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure...
- A comparison of colon and rectal somatic DNA alterationsMartha L Slattery
Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
Dis Colon Rectum 52:1304-11. 2009..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors...
- Laparoscopic versus open surgery for rectal cancer: long-term oncologic resultsChristophe Laurent
Department of Colorectal Surgery, Saint Andre Hospital, University of Bordeaux, Bordeaux 33075, France
Ann Surg 250:54-61. 2009..The goal was to assess long-term oncologic outcome after laparoscopic versus open surgery for rectal cancer and to evaluate the impact of conversion...
- Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancerK Bujko
Department of Radiotherapy, Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
Br J Surg 93:1215-23. 2006..The aim of this study was to compare survival, local control and late toxicity in the two treatment groups...
- Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysisShandra Bipat
Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Radiology 232:773-83. 2004..To perform a meta-analysis to compare endoluminal ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging in rectal cancer staging...
- Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgeryLuiz Felipe de Campos-Lobato
Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue A30, Cleveland, OH 44195, USA
J Gastrointest Surg 15:444-50. 2011..The aim of this study was to determine the effect of a longer interval between neoadjuvant chemoradiation and surgery on perioperative morbidity and oncologic outcomes...
- Preoperative short-course radiotherapy with delayed surgery in primary rectal cancerD Pettersson
Department of Molecular Medicine and Surgery, Uppsala, Sweden
Br J Surg 99:577-83. 2012..This study examined early toxicity, response to radiotherapy (RT) and short-term outcomes of SRT-delay...
- Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissectionMartin R Weiser
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Ann Surg 249:236-42. 2009....
- Circumferential resection margin as a prognostic factor in rectal cancerT E Bernstein
Department of Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Br J Surg 96:1348-57. 2009..This study examined the prognostic impact of the circumferential resection margin (CRM) in patients with rectal cancer treated by total mesorectal excision (TME) with or without radiotherapy...
- A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancerJulie A Cornish
Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, UK
Ann Surg Oncol 14:2056-68. 2007..The aim of this study was to compare QoL following abdominoperineal excision of rectum (APER) with that after anterior resection (AR) in patients with rectal cancer...
- Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancerM Caricato
Department of Surgery, Campus Bio Medico University, Via Longoni 47, 00155 Rome, Italy
Eur J Surg Oncol 33:724-8. 2007..The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor...
- Serum CEA as a predictor for the response to preoperative chemoradiation in rectal cancerYoon Ah Park
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
J Surg Oncol 93:145-50. 2006..The aim of this study was to investigate the predictive value of serum carcinoembryonic antigen (CEA) levels for the tumor response to preoperative CRT in rectal cancer patients...
- Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancerA Nesbakken
Department of Surgery, Aker Hospital, N 0514 Oslo, Norway
Br J Surg 88:400-4. 2001..Few studies have evaluated the long-term functional outcome after anastomotic leakage in the treatment of rectal cancer...
- Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trialCarlo Aschele
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
J Clin Oncol 29:2773-80. 2011..To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer...
- Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trialCorrie A M Marijnen
Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Oncol 23:1847-58. 2005..This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 x 5 Gy)...
- Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective studyPatrick A Hein
Department of Radiotherapy and Radiooncology, University of Innsbruck, Innsbruck, Austria
Eur J Radiol 45:214-22. 2003..To evaluate the clinical value of diffusion-weighted magnetic resonance imaging (DW-MRI) to monitor response of primary carcinoma of the rectum to preoperative chemoradiation by measuring tumor apparent diffusion coefficient (ADC)...
- Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trialWillem van Gijn
Leiden University Medical Centre, Leiden, The Netherlands
Lancet Oncol 12:575-82. 2011..The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years...
- Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 yearsRolf Sauer
University of Erlangen, Erlangen, Germany
J Clin Oncol 30:1926-33. 2012..However, after a median follow-up of 46 months, no survival benefit could be shown. Here, we report long-term results with a median follow-up of 134 months...
- Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial- Foxtrot Collaborative Group
The FOxTROT Trial, Birmingham Clinical Trials Unit, Robert Aitken Institute, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Lancet Oncol 13:1152-60. 2012..The FOxTROT trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer...
- Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trialRalf Dieter Hofheinz
University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Lancet Oncol 13:579-88. 2012..Fluorouracil-based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. We investigated the efficacy and safety of substituting fluorouracil with the oral prodrug capecitabine...
- Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trialPeter Matthiessen
Department of Surgery, Orebro University Hospital, Orebro, Sweden
Ann Surg 246:207-14. 2007....
- Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancerZ G Zhou
Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China
Surg Endosc 18:1211-5. 2004....
- COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancerM Buunen
Department of Surgery, Dalhousie University, QE II Health Sciences Center, Victoria Building Room 8 838, 1278 Tower Road, Halifax NSB3H2Y9, Canada
Dan Med Bull 56:89-91. 2009..Completion of inclusion is expected by the end of 2009. Trial registration: Clinicaltrials.gov, identifier: NCT00297791 (www.clinicaltrials.gov)...
- Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapyC Bengala
Division of Medical Oncology, Department of Oncology, Hematology and Respiratory Disease, University Hospital, University of Modena and Reggio Emilia, Via del Pozzo, 71, Modena 41100, Italy
Br J Cancer 103:1019-24. 2010..Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their prognostic significance in colorectal cancer patients is still unclear...
- KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapyJochen Gaedcke
Department of General and Visceral Surgery, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
Radiother Oncol 94:76-81. 2010..KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established...
- Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancerClaus Rodel
Department of Radiation Therapy, University of Erlangen, Universitatsstr 27, D 91054 Erlangen, Germany
J Clin Oncol 23:8688-96. 2005..We assessed the impact of tumor regression grading (TRG) and its value in correlation to established prognostic factors in a cohort of rectal carcinoma patients treated by preoperative chemoradiotherapy (CRT)...
- A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerGiuseppina Della Vittoria Scarpati
Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
Int J Radiat Oncol Biol Phys 83:1113-9. 2012..We studied miRNA expression in tumor biopsies of patients with rectal cancer to identify a specific "signature" correlating with pathological complete response (pCR) after neoadjuvant chemoradiotherapy...
- Epidemiology and management of liver metastases from colorectal cancerSylvain Manfredi
Registre Bourguignon des Cancers Digestifs, Faculte de Medecine, Dijon Cedex, France
Ann Surg 244:254-9. 2006..The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases...
- Identification of a quantitative MINT locus methylation profile predicting local regional recurrence of rectal cancerMichiel F G de Maat
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 16:2811-8. 2010..In this study, we evaluated the significance of a quantitative epigenetic multimarker panel analysis of primary tumors to predict local recurrence in rectal cancer patients from a retrospective multicenter clinical trial...
- Immunohistochemical analysis of tumour regression grade for rectal cancer after neoadjuvant chemoradiotherapyV Moreno García
Service of Medical Oncology, La Paz University Hospital, Madrid, Spain
Colorectal Dis 13:989-98. 2011..The purpose of this study was to find an immunohistochemical pattern to permit improved stratification of intermediate responders defined by disease free (DFS) and overall survival (OS)...
- Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04Samuel Y Ngan
FRANZCR, Division of Radiation Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
J Clin Oncol 30:3827-33. 2012..To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer...
- Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevanceDietrich Doll
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
World J Surg 33:340-7. 2009..Neoadjuvant radiochemotherapy for rectal carcinoma reduces the number of lymph nodes in the resection specimen; the prognostic impact of this reduced lymph node yield has not been determined...
- Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implicationsLeire Arbea
Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain
Radiat Oncol 5:17. 2010....
- A systematic approach to the interpretation of preoperative staging MRI for rectal cancerFiona G M Taylor
Department of Colorectal Surgery, Mayday University Hospital, Croydon, United Kingdom
AJR Am J Roentgenol 191:1827-35. 2008..The purpose of this article is to provide an aid to the systematic evaluation of MRI in staging rectal cancer...
- Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trialMartijn Hgm van der Pas
VU University Medical Center, Amsterdam, Netherlands
Lancet Oncol 14:210-8. 2013..The aim in the COlorectal cancer Laparoscopic or Open Resection (COLOR II) trial was to compare laparoscopic and open surgery in patients with rectal cancer...
- Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective studyPeirong Ding
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Ann Surg 256:111-6. 2012..To characterize patterns of recurrence in locally advanced rectal cancer treated with combined modality therapy (CMT): neoadjuvant chemoradiation + total mesorectal excision + adjuvant chemotherapy...
- Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:1750-5. 2007..The objective of this study was to identify predictive factors for pathologic complete response and tumor downstaging after preoperative chemoradiation for rectal cancer...
- Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114Jeffrey A Meyerhardt
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 22:648-57. 2004..To study the relationship between body mass index (BMI) and rates of sphincter-preserving operations, overall survival, cancer recurrence, and treatment-related toxicities in patients with rectal cancer...
- Long-term follow-up of preoperative pelvic radiation therapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04-01)Jong Hoon Lee
Department of Radiation Oncology, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Int J Radiat Oncol Biol Phys 84:955-61. 2012....
- Preoperative chemoradiotherapy (CRT) followed by laparoscopic surgery for rectal cancer: predictors of the tumor response and the long-term oncologic outcomesJong Hoon Lee
Department of Radiation Oncology, St Vincent s Hospital, The Catholic University of Korea, College of Medicine, Suwon, Korea
Int J Radiat Oncol Biol Phys 81:431-8. 2011..We have evaluated the predictors of a tumor response to chemoradiotherapy (CRT) and the long-term oncologic outcomes of preoperative CRT and laparoscopic surgery for patients who suffer from rectal cancer...
- Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancerJason M Samuelian
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, USA
Int J Radiat Oncol Biol Phys 82:1981-7. 2012..The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes...
- Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II studySun Young Kim
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
Int J Radiat Oncol Biol Phys 81:677-83. 2011..To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer...
- Risk factors for fecal incontinence after intersphincteric resection for rectal cancerQuentin Denost
Department of Digestive Surgery, CHU Bordeaux, Saint Andre Hospital, Universite Victor Segalen, Bordeaux, France
Dis Colon Rectum 54:963-8. 2011..Intersphincteric resection allows sphincter preservation in low rectal cancer but may have poor functional results, including frequent bowel movements, urgency, and incontinence...
- Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgeryJi Won Park
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
Int J Radiat Oncol Biol Phys 74:810-7. 2009..To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer...
- Preoperative or postoperative therapy for stage II or III rectal cancer: an updated practice guidelineR K S Wong
Princess Margaret Hospital, University Health Network, Radiation Medicine Program, Toronto, Ontario, Canada
Clin Oncol (R Coll Radiol) 22:265-71. 2010..What is the role of postoperative radiotherapy and/or chemotherapy for patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy, in terms of improving survival and delaying local recurrence?..
- Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapyJanine M Davies
Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
Radiat Oncol 6:114. 2011..Our objective was to explore the relationships of KRAS and BRAF mutation status with p-AKT and p-ERK and outcomes in RC...
- The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancerRodrigo O Perez
Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Dis Colon Rectum 52:1137-43. 2009..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
- Preoperative 3T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequenceJurgen J Futterer
Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
Eur J Radiol 65:66-71. 2008..The purpose of our study was to evaluate the image quality and diagnostic performance of two-dimensional (D) turbo spin echo (TSE) and 3D T2-weighted TSE MR imaging in local staging of rectal cancer at 3T...
- Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patientsVincenzo Valentini
Department of Radiotherapy, Catholic University of the Sacred Heart, Policlinico Universitario Agostino Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
Int J Radiat Oncol Biol Phys 53:664-74. 2002....
- Urinary dysfunction after rectal cancer treatment is mainly caused by surgeryM M Lange
Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
Br J Surg 95:1020-8. 2008..This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors...
- Molecular targeted treatment and radiation therapy for rectal cancerFriederike Marquardt
Department of Radiation Therapy, University of Frankfurt Main, Germany
Strahlenther Onkol 185:371-8. 2009..An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols...
- Locally advanced rectal carcinoma treated with preoperative chemotherapy and radiation therapy: preliminary analysis of diffusion-weighted MR imaging for early detection of tumor histopathologic downstagingYing Shi Sun
Key laboratory of Carcinogenesis and Translational Research, Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
Radiology 254:170-8. 2010....
- Diffusion MRI for prediction of response of rectal cancer to chemoradiationAndrzej Dzik-Jurasz
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
Lancet 360:307-8. 2002..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
- Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapyMarian Grade
Department of General and Visceral Surgery, University Medicine, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
Cancer Genet Cytogenet 193:19-28. 2009..This will require validation in a larger cohort of patients...
- The posterior approach for low retrorectal tumors in adultsNicolas Buchs
Unit of Proctology, Department of Surgery, University Hospital of Geneva, 24, Rue Micheli du Crest, 1205 Geneva, Switzerland
Int J Colorectal Dis 22:381-5. 2007..The aim of this study is to evaluate early complete surgical resection by a perineal approach as the therapy-of-choice for tumors under the sacral promontory...
- Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancerD Pettersson
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Br J Surg 97:580-7. 2010..The present interim analysis assessed feasibility, compliance and complications after RT and surgery...
- Addition of bevacizumab to XELOX induction therapy plus concomitant capecitabine-based chemoradiotherapy in magnetic resonance imaging-defined poor-prognosis locally advanced rectal cancer: the AVACROSS studyMiguel Nogue
Department of Oncology, Hospital General de Vic, C Francesc Pla El Vigatà, 1, 08500 Vic, Spain
Oncologist 16:614-20. 2011..The objective of the current study was to assess the efficacy and toxicity of adding bevacizumab to induction chemotherapy followed by preoperative bevacizumab-based chemoradiotherapy in patients with locally advanced rectal cancer...
- Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resectionGarrett M Nash
Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Dis Colon Rectum 53:1365-73. 2010..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
- Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trialsK Bujko
Department of Radiotherapy, The Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
Ann Oncol 21:1743-50. 2010..To evaluate this discrepancy further, a systematic review of relevant randomised trials was undertaken...
- Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapyBrunella Barbaro
Department of Bioimaging and Radiological Sciences, Catholic University, School of Medicine, Largo A Gemelli 1, 00168 Rome, Italy
Radiographics 30:699-716. 2010..Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.303095085/-/DC1...
- Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapyAngelita Habr-Gama
Department of Gastroenterology, University of Sao Paulo School of Medicine, and Hospital Alemão Oswaldo Cruz HAOC, Sao Paulo, Brazil
J Gastrointest Surg 10:1319-28; discussion 1328-9. 2006..Survival in these patients is significantly affected by systemic failure. Exclusive local failure occurs late after CRT completion and is frequently amenable to salvage therapy...
- Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancerE Kapiteijn
Department of Surgery, Leiden University Medical Center, The Netherlands
N Engl J Med 345:638-46. 2001..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
- Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancerSunil Krishnan
Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 66:762-71. 2006..The aim of this study was to determine the efficacy of capecitabine (Xeloda), an oral fluoropyrimidine, as a radiosensitizer in the neoadjuvant treatment of locally advanced rectal cancer (LARC)...
- Neoadjuvant treatment response as an early response indicator for patients with rectal cancerIn Ja Park
The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
J Clin Oncol 30:1770-6. 2012..The purpose of this study was to assess and compare oncologic outcomes associated with the degree of pathologic response after chemoradiotherapy...
- Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trialClaus Rodel
Department of Radiotherapy and Oncology, University of Frankfurt, Frankfurt, Germany
Lancet Oncol 13:679-87. 2012..With the aim of improving disease-free survival (DFS), this phase 3 study (CAO/ARO/AIO-04) integrated oxaliplatin into standard treatment...
- Associations between apoE genotype and colon and rectal cancerMartha L Slattery
Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
Carcinogenesis 26:1422-9. 2005....
- Chemotherapy with preoperative radiotherapy in rectal cancerJean Francois Bosset
Department of Radiation Therapy, University of Franche Comte, Besancon, France
N Engl J Med 355:1114-23. 2006..Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer...
- Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2Jean Pierre Gerard
Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
J Clin Oncol 28:1638-44. 2010..Neoadjuvant chemoradiotherapy is considered a standard approach for T3-4 M0 rectal cancer. In this situation, we compared neoadjuvant radiotherapy plus capecitabine with dose-intensified radiotherapy plus capecitabine and oxaliplatin...
- Preoperative staging of rectal cancer using magnetic resonance imaging with external phase-arrayed coilsGiuseppe Gagliardi
Department of Surgical Oncology, School of Medicine, Yale University, 333 Cedar St, New Haven, CT 06520, USA
Arch Surg 137:447-51. 2002..Rectal cancer can be accurately staged preoperatively by magnetic resonance imaging (MRI) with external phase-arrayed coils...
- Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectumYumi Mashimo
Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
J Gastroenterol Hepatol 23:218-21. 2008..The aim of the present study was to clarify the clinical usefulness of a novel technique named endoscopic submucosal resection with a ligation device (ESMR-L) in a large number of rectal carcinoid tumors...
- Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinomaDavid E Stein
Division of Colorectal Surgery, Department of Surgery, Jefferson Medical College, Philadelphia, PA, USA
Dis Colon Rectum 46:448-53. 2003..Our purpose was to determine whether a longer time interval between completion of therapy and resection increases tumor downstaging and affects perioperative morbidity...
- Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sexRobert S Krouse
Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
J Clin Oncol 27:4664-70. 2009..Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL)...
- Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approachC Eckmann
Department of Surgery, Medical University Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Int J Colorectal Dis 19:128-33. 2004..This study analyzed the results of a standardized approach in anastomotic leakage following low anterior resection for rectal cancer without performance of a protective ileostomy during the primary operation...
- Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II/III trialsA Hartley
Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Br J Radiol 78:934-8. 2005..Important factors not considered in this analysis include the variability in pathological examination and in the time interval between CRT and surgery. In addition, the toxicity of the CRT regimens requires further investigation...
- Intensity-modulated radiotherapy in patients with locally advanced rectal cancer reduces volume of bowel treated to high dose levelsM Teresa Guerrero Urbano
Department of Clinical Oncology, Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
Int J Radiat Oncol Biol Phys 65:907-16. 2006..To investigate the potential for intensity-modulated radiotherapy (IMRT) to spare the bowel in rectal tumors...
- Does positron emission tomography change management in primary rectal cancer? A prospective assessmentAlexander G Heriot
Department of Surgery, St Vincent s Hospital, Melbourne, Australia
Dis Colon Rectum 47:451-8. 2004..This study therefore prospectively assesses the impact of position emission tomography scanning on the management of primary rectal cancer...
- Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoidK Birkenkamp-Demtroder
Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
Gut 54:374-84. 2005..The aim of this study was to investigate differences in gene expression...
- Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survivalNam Kyu Kim
Colorectal Cancer Clinic, Severance Hospital, Yonsei University Medical Center, Yonsei University College of Medicine, Seoul, Korea
Ann Surg 244:1024-30. 2006....
- An interval >7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancerHagit Tulchinsky
Proctology Unit, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Ann Surg Oncol 15:2661-7. 2008....
- Quality of life among five-year survivors after treatment for very low rectal cancer with or without a permanent abdominal stomaC Fucini
Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery, University of Florence, Viale Morgagni, 85, 50134, Firenze, Italy
Ann Surg Oncol 15:1099-106. 2008....
- Inadvertent perforation during rectal cancer resection in NorwayM T Eriksen
Department of Surgery, Buskerud Hospital, Drammen, Norway
Br J Surg 91:210-6. 2004..The purpose of this study was to examine intraoperative perforation following the introduction of mesorectal excision as a standard surgical technique in Norway...
- A comparative clinical study of short-term results of laparoscopic surgery for rectal cancer during the learning curveIvan Arteaga Gonzalez
Department of Gastrointestinal Surgery, Hospital Universitario de Canarias HUC, Ofra, s n La Cuesta, 38320 La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain
Int J Colorectal Dis 21:590-5. 2006..The aim of this study was to assess the results of laparoscopic surgery for rectal carcinoma (LSRC) during the learning curve throughout the introduction of this technique at our medical center...
- Technique and long-term results of intersphincteric resection for low rectal cancerRudolf Schiessel
Department of Surgery, Danube Hospital SMZ Ost, Vienna, Austria
Dis Colon Rectum 48:1858-65; discussion 1865-7. 2005..This study was designed to evaluate the long-term results of this method focused on continence function and oncologic results...
- Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02N Wolmark
N Wolmark, D L Wickerham, E R Fisher, B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP Operations Center, Pittsburgh, PA 15212, USA
J Natl Cancer Inst 92:388-96. 2000..This study was carried out to address this issue. An additional aim was to determine whether leucovorin (LV)-modulated 5-fluorouracil (5-FU) is superior to the combination of 5-FU, semustine, and vincristine (MOF) in men...
- Long-term results of intersphincteric resection for low rectal cancerReza Chamlou
Departments of Digestive Surgery, Hopital Saint Antoine AP HP, Universite Pierre et Marie Curie, Paris VI, Paris, France
Ann Surg 246:916-21; discussion 921-2. 2007..Thus, intersphincteric resection (ISR) has been proposed as an alternative to abdominoperineal resection for selected low rectal cancer...
- Risk of lymph node metastasis in T1 carcinoma of the colon and rectumRiccardo Nascimbeni
Division of Colorectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Dis Colon Rectum 45:200-6. 2002..Several recent reports of high local recurrence and lymph node metastasis in T1 carcinoma of the rectum prompted us to study the risk factors for lymph node metastasis in these lesions...
- Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01B Fisher
University of Pittsburgh, PA
J Natl Cancer Inst 80:21-9. 1988..The observed advantage was restricted to males. Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival...
- The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancerMaarten Lambrecht
Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Leuven, Belgium
Acta Oncol 49:956-63. 2010..To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy (CRT) and diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for the prediction of pathological response (pCR) in rectal cancer patients...
- Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancerMasaaki Ito
Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Chiba, Japan
Dis Colon Rectum 52:64-70. 2009..The purpose of this study was to identify factors that have a negative impact on anal function after intersphincteric resection...
- Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancerHideki Ueno
Department of Surgery I, National Defense Medical College, Saitama, Japan
Ann Surg 239:34-42. 2004..To clarify the preoperative parameters of the required distal margin that can be applied to the criteria of sphincter-preserving surgery in rectal cancer...
- Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profilingSigurd Folkvord
Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
Int J Radiat Oncol Biol Phys 78:555-62. 2010..This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC)...
- A gene expression signature for chemoradiosensitivity of colorectal cancer cellsMelanie Spitzner
Department of General and Visceral Surgery, Georg August University, Gottingen, Germany
Int J Radiat Oncol Biol Phys 78:1184-92. 2010..However, tumor response to multimodal treatment has varied greatly, ranging from complete resistance to complete pathologic regression. The prediction of the response is, therefore, an important clinical need...
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- Timing of Rectal Cancer Response to ChemoradiationJulio Garcia Aguilar; Fiscal Year: 2009..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
- Folate, DNA Methylation and Breast TumorigenesisJoshua Miller; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The Influence of Companions and Socio-Demographic Characteristics on Patients' InSusan Eggly; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Energy Balance, Organochlorine Exposure, and Possible Toxicologic EffectsAnneclaire De Roos; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Positron Emission Tomography in Prostate CancerFarrokh Dehdashti; Fiscal Year: 2008..PET may also contribute significant prognostic information that may affect the decision to administer early adjuvant therapy to delay or prevent recurrence. [unreadable] [unreadable]..
- Molecular Analysis of Scarless Fetal Wound HealingSandeep Kathju; Fiscal Year: 2007..With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both. ..
- Industrial Pollutants and Risk of Non-Hodgkins LymphomaAnneclaire De Roos; Fiscal Year: 2006..abstract_text> ..
- PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCERJose Guillem; Fiscal Year: 2001..abstract_text> ..
- Sleep Disturbances in People with Cancer and CaregiversAnn Berger; Fiscal Year: 2004..abstract_text> ..
- B12 Absorption, Kinetics and Transcobalamin GenotypeJoshua Miller; Fiscal Year: 2004..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
- Hepatitis Virus, Alcohol Exposure and Oxidative StressManal Hassan; Fiscal Year: 2002..Serum Se, GPx activity, lipid peroxides and oxidative DNA damage will be measured in relation to HCV and alcohol intake history. ..
- Replication Study of Breast Cancer Susceptibility Genes in BlacksDezheng Huo; Fiscal Year: 2010..This study will advance understanding the genetic risk factors for breast cancer in women of African descent and will be invaluable in developing novel prevention strategies in the future. ..
- Fatigue & Breast Cancer-A Behavioral Sleep InterventionAnn Berger; Fiscal Year: 2006..Statistical analyses include RM-ANOVA, generalized estimation equation methodology and multiple regression analysis. Results may inform development of clinical guidelines for fatigue management during adjuvant CT. ..
- Evaluation of Biliary Strictures by IDUS, DIA, and FISHMichael Levy; Fiscal Year: 2005..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
- International Conference on Malignant Bowel ObstructionRobert Krouse; Fiscal Year: 2004..Using MBO as a model, a consensus will be attained for methodological approaches and the implementation of palliative care research. ..