rectal neoplasms

Summary

Summary: Tumors or cancer of the RECTUM.

Top Publications

  1. ncbi The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection
    Sheng Xiang Rao
    Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
    Eur J Radiol 65:299-303. 2008
  2. ncbi A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy
    G Lezoche
    Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
    Surg Endosc 22:352-8. 2008
  3. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
  4. ncbi The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
  5. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009
  6. ncbi Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy
    H Birgisson
    Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala, Uppsala, Sweden
    Br J Surg 95:206-13. 2008
  7. doi Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
    Monique Maas
    Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands
    Lancet Oncol 11:835-44. 2010
  8. pmc Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03
    Mark S Roh
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
    J Clin Oncol 27:5124-30. 2009
  9. ncbi Effective surgical adjuvant therapy for high-risk rectal carcinoma
    J E Krook
    Duluth Community Clinical Oncology Program, Minn
    N Engl J Med 324:709-15. 1991
  10. pmc Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    Mai Yamauchi
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Gut 61:847-54. 2012

Research Grants

  1. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  2. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  3. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  4. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  5. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
  6. Folate, DNA Methylation and Breast Tumorigenesis
    Joshua Miller; Fiscal Year: 2008
  7. The Influence of Companions and Socio-Demographic Characteristics on Patients' In
    Susan Eggly; Fiscal Year: 2008
  8. Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Anneclaire De Roos; Fiscal Year: 2008
  9. Positron Emission Tomography in Prostate Cancer
    Farrokh Dehdashti; Fiscal Year: 2008
  10. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007

Detail Information

Publications372 found, 100 shown here

  1. ncbi The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection
    Sheng Xiang Rao
    Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
    Eur J Radiol 65:299-303. 2008
    ..To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone...
  2. ncbi A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy
    G Lezoche
    Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
    Surg Endosc 22:352-8. 2008
    ....
  3. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
    ..In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer...
  4. ncbi The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
    ..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
  5. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009
    ..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
  6. ncbi Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy
    H Birgisson
    Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala, Uppsala, Sweden
    Br J Surg 95:206-13. 2008
    ..The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and to determine their relationship to preoperative radiation therapy...
  7. doi Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
    Monique Maas
    Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands
    Lancet Oncol 11:835-44. 2010
    ..This study established whether patients with pCR have better long-term outcome than do those without pCR...
  8. pmc Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03
    Mark S Roh
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
    J Clin Oncol 27:5124-30. 2009
    ..The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma...
  9. ncbi Effective surgical adjuvant therapy for high-risk rectal carcinoma
    J E Krook
    Duluth Community Clinical Oncology Program, Minn
    N Engl J Med 324:709-15. 1991
    ..We designed a combination regimen to optimize the contribution of chemotherapy, decrease recurrence, and improve survival as compared with adjuvant radiation alone...
  10. pmc Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    Mai Yamauchi
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Gut 61:847-54. 2012
    ..Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure...
  11. pmc A comparison of colon and rectal somatic DNA alterations
    Martha L Slattery
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 52:1304-11. 2009
    ..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors...
  12. doi Laparoscopic versus open surgery for rectal cancer: long-term oncologic results
    Christophe Laurent
    Department of Colorectal Surgery, Saint Andre Hospital, University of Bordeaux, Bordeaux 33075, France
    Ann Surg 250:54-61. 2009
    ..The goal was to assess long-term oncologic outcome after laparoscopic versus open surgery for rectal cancer and to evaluate the impact of conversion...
  13. ncbi Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
    K Bujko
    Department of Radiotherapy, Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
    Br J Surg 93:1215-23. 2006
    ..The aim of this study was to compare survival, local control and late toxicity in the two treatment groups...
  14. ncbi Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis
    Shandra Bipat
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 232:773-83. 2004
    ..To perform a meta-analysis to compare endoluminal ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging in rectal cancer staging...
  15. doi Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery
    Luiz Felipe de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue A30, Cleveland, OH 44195, USA
    J Gastrointest Surg 15:444-50. 2011
    ..The aim of this study was to determine the effect of a longer interval between neoadjuvant chemoradiation and surgery on perioperative morbidity and oncologic outcomes...
  16. doi Preoperative short-course radiotherapy with delayed surgery in primary rectal cancer
    D Pettersson
    Department of Molecular Medicine and Surgery, Uppsala, Sweden
    Br J Surg 99:577-83. 2012
    ..This study examined early toxicity, response to radiotherapy (RT) and short-term outcomes of SRT-delay...
  17. doi Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 249:236-42. 2009
    ....
  18. doi Circumferential resection margin as a prognostic factor in rectal cancer
    T E Bernstein
    Department of Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Br J Surg 96:1348-57. 2009
    ..This study examined the prognostic impact of the circumferential resection margin (CRM) in patients with rectal cancer treated by total mesorectal excision (TME) with or without radiotherapy...
  19. ncbi A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer
    Julie A Cornish
    Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, UK
    Ann Surg Oncol 14:2056-68. 2007
    ..The aim of this study was to compare QoL following abdominoperineal excision of rectum (APER) with that after anterior resection (AR) in patients with rectal cancer...
  20. ncbi Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer
    M Caricato
    Department of Surgery, Campus Bio Medico University, Via Longoni 47, 00155 Rome, Italy
    Eur J Surg Oncol 33:724-8. 2007
    ..The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor...
  21. ncbi Serum CEA as a predictor for the response to preoperative chemoradiation in rectal cancer
    Yoon Ah Park
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 93:145-50. 2006
    ..The aim of this study was to investigate the predictive value of serum carcinoembryonic antigen (CEA) levels for the tumor response to preoperative CRT in rectal cancer patients...
  22. ncbi Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer
    A Nesbakken
    Department of Surgery, Aker Hospital, N 0514 Oslo, Norway
    Br J Surg 88:400-4. 2001
    ..Few studies have evaluated the long-term functional outcome after anastomotic leakage in the treatment of rectal cancer...
  23. doi Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial
    Carlo Aschele
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Clin Oncol 29:2773-80. 2011
    ..To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer...
  24. ncbi Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:1847-58. 2005
    ..This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 x 5 Gy)...
  25. ncbi Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective study
    Patrick A Hein
    Department of Radiotherapy and Radiooncology, University of Innsbruck, Innsbruck, Austria
    Eur J Radiol 45:214-22. 2003
    ..To evaluate the clinical value of diffusion-weighted magnetic resonance imaging (DW-MRI) to monitor response of primary carcinoma of the rectum to preoperative chemoradiation by measuring tumor apparent diffusion coefficient (ADC)...
  26. doi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
    Willem van Gijn
    Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 12:575-82. 2011
    ..The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years...
  27. doi Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years
    Rolf Sauer
    University of Erlangen, Erlangen, Germany
    J Clin Oncol 30:1926-33. 2012
    ..However, after a median follow-up of 46 months, no survival benefit could be shown. Here, we report long-term results with a median follow-up of 134 months...
  28. pmc Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial
    - Foxtrot Collaborative Group
    The FOxTROT Trial, Birmingham Clinical Trials Unit, Robert Aitken Institute, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Lancet Oncol 13:1152-60. 2012
    ..The FOxTROT trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer...
  29. doi Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial
    Ralf Dieter Hofheinz
    University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Lancet Oncol 13:579-88. 2012
    ..Fluorouracil-based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. We investigated the efficacy and safety of substituting fluorouracil with the oral prodrug capecitabine...
  30. pmc Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial
    Peter Matthiessen
    Department of Surgery, Orebro University Hospital, Orebro, Sweden
    Ann Surg 246:207-14. 2007
    ....
  31. ncbi Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancer
    Z G Zhou
    Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China
    Surg Endosc 18:1211-5. 2004
    ....
  32. ncbi COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancer
    M Buunen
    Department of Surgery, Dalhousie University, QE II Health Sciences Center, Victoria Building Room 8 838, 1278 Tower Road, Halifax NSB3H2Y9, Canada
    Dan Med Bull 56:89-91. 2009
    ..Completion of inclusion is expected by the end of 2009. Trial registration: Clinicaltrials.gov, identifier: NCT00297791 (www.clinicaltrials.gov)...
  33. pmc Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy
    C Bengala
    Division of Medical Oncology, Department of Oncology, Hematology and Respiratory Disease, University Hospital, University of Modena and Reggio Emilia, Via del Pozzo, 71, Modena 41100, Italy
    Br J Cancer 103:1019-24. 2010
    ..Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their prognostic significance in colorectal cancer patients is still unclear...
  34. doi KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy
    Jochen Gaedcke
    Department of General and Visceral Surgery, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Radiother Oncol 94:76-81. 2010
    ..KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established...
  35. ncbi Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    Claus Rodel
    Department of Radiation Therapy, University of Erlangen, Universitatsstr 27, D 91054 Erlangen, Germany
    J Clin Oncol 23:8688-96. 2005
    ..We assessed the impact of tumor regression grading (TRG) and its value in correlation to established prognostic factors in a cohort of rectal carcinoma patients treated by preoperative chemoradiotherapy (CRT)...
  36. doi A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
    Giuseppina Della Vittoria Scarpati
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Int J Radiat Oncol Biol Phys 83:1113-9. 2012
    ..We studied miRNA expression in tumor biopsies of patients with rectal cancer to identify a specific "signature" correlating with pathological complete response (pCR) after neoadjuvant chemoradiotherapy...
  37. pmc Epidemiology and management of liver metastases from colorectal cancer
    Sylvain Manfredi
    Registre Bourguignon des Cancers Digestifs, Faculte de Medecine, Dijon Cedex, France
    Ann Surg 244:254-9. 2006
    ..The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases...
  38. doi Identification of a quantitative MINT locus methylation profile predicting local regional recurrence of rectal cancer
    Michiel F G de Maat
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 16:2811-8. 2010
    ..In this study, we evaluated the significance of a quantitative epigenetic multimarker panel analysis of primary tumors to predict local recurrence in rectal cancer patients from a retrospective multicenter clinical trial...
  39. doi Immunohistochemical analysis of tumour regression grade for rectal cancer after neoadjuvant chemoradiotherapy
    V Moreno García
    Service of Medical Oncology, La Paz University Hospital, Madrid, Spain
    Colorectal Dis 13:989-98. 2011
    ..The purpose of this study was to find an immunohistochemical pattern to permit improved stratification of intermediate responders defined by disease free (DFS) and overall survival (OS)...
  40. doi Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04
    Samuel Y Ngan
    FRANZCR, Division of Radiation Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    J Clin Oncol 30:3827-33. 2012
    ..To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer...
  41. doi Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevance
    Dietrich Doll
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    World J Surg 33:340-7. 2009
    ..Neoadjuvant radiochemotherapy for rectal carcinoma reduces the number of lymph nodes in the resection specimen; the prognostic impact of this reduced lymph node yield has not been determined...
  42. pmc Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications
    Leire Arbea
    Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain
    Radiat Oncol 5:17. 2010
    ....
  43. doi A systematic approach to the interpretation of preoperative staging MRI for rectal cancer
    Fiona G M Taylor
    Department of Colorectal Surgery, Mayday University Hospital, Croydon, United Kingdom
    AJR Am J Roentgenol 191:1827-35. 2008
    ..The purpose of this article is to provide an aid to the systematic evaluation of MRI in staging rectal cancer...
  44. doi Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial
    Martijn Hgm van der Pas
    VU University Medical Center, Amsterdam, Netherlands
    Lancet Oncol 14:210-8. 2013
    ..The aim in the COlorectal cancer Laparoscopic or Open Resection (COLOR II) trial was to compare laparoscopic and open surgery in patients with rectal cancer...
  45. doi Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study
    Peirong Ding
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:111-6. 2012
    ..To characterize patterns of recurrence in locally advanced rectal cancer treated with combined modality therapy (CMT): neoadjuvant chemoradiation + total mesorectal excision + adjuvant chemotherapy...
  46. ncbi Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer
    Prajnan Das
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:1750-5. 2007
    ..The objective of this study was to identify predictive factors for pathologic complete response and tumor downstaging after preoperative chemoradiation for rectal cancer...
  47. ncbi Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114
    Jeffrey A Meyerhardt
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 22:648-57. 2004
    ..To study the relationship between body mass index (BMI) and rates of sphincter-preserving operations, overall survival, cancer recurrence, and treatment-related toxicities in patients with rectal cancer...
  48. doi Long-term follow-up of preoperative pelvic radiation therapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04-01)
    Jong Hoon Lee
    Department of Radiation Oncology, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 84:955-61. 2012
    ....
  49. doi Preoperative chemoradiotherapy (CRT) followed by laparoscopic surgery for rectal cancer: predictors of the tumor response and the long-term oncologic outcomes
    Jong Hoon Lee
    Department of Radiation Oncology, St Vincent s Hospital, The Catholic University of Korea, College of Medicine, Suwon, Korea
    Int J Radiat Oncol Biol Phys 81:431-8. 2011
    ..We have evaluated the predictors of a tumor response to chemoradiotherapy (CRT) and the long-term oncologic outcomes of preoperative CRT and laparoscopic surgery for patients who suffer from rectal cancer...
  50. doi Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancer
    Jason M Samuelian
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, USA
    Int J Radiat Oncol Biol Phys 82:1981-7. 2012
    ..The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes...
  51. doi Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study
    Sun Young Kim
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Int J Radiat Oncol Biol Phys 81:677-83. 2011
    ..To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer...
  52. doi Risk factors for fecal incontinence after intersphincteric resection for rectal cancer
    Quentin Denost
    Department of Digestive Surgery, CHU Bordeaux, Saint Andre Hospital, Universite Victor Segalen, Bordeaux, France
    Dis Colon Rectum 54:963-8. 2011
    ..Intersphincteric resection allows sphincter preservation in low rectal cancer but may have poor functional results, including frequent bowel movements, urgency, and incontinence...
  53. doi Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery
    Ji Won Park
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
    Int J Radiat Oncol Biol Phys 74:810-7. 2009
    ..To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer...
  54. doi Preoperative or postoperative therapy for stage II or III rectal cancer: an updated practice guideline
    R K S Wong
    Princess Margaret Hospital, University Health Network, Radiation Medicine Program, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 22:265-71. 2010
    ..What is the role of postoperative radiotherapy and/or chemotherapy for patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy, in terms of improving survival and delaying local recurrence?..
  55. pmc Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy
    Janine M Davies
    Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
    Radiat Oncol 6:114. 2011
    ..Our objective was to explore the relationships of KRAS and BRAF mutation status with p-AKT and p-ERK and outcomes in RC...
  56. doi The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancer
    Rodrigo O Perez
    Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Dis Colon Rectum 52:1137-43. 2009
    ..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
  57. doi Preoperative 3T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequence
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Radiol 65:66-71. 2008
    ..The purpose of our study was to evaluate the image quality and diagnostic performance of two-dimensional (D) turbo spin echo (TSE) and 3D T2-weighted TSE MR imaging in local staging of rectal cancer at 3T...
  58. ncbi Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients
    Vincenzo Valentini
    Department of Radiotherapy, Catholic University of the Sacred Heart, Policlinico Universitario Agostino Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
    Int J Radiat Oncol Biol Phys 53:664-74. 2002
    ....
  59. doi Urinary dysfunction after rectal cancer treatment is mainly caused by surgery
    M M Lange
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 95:1020-8. 2008
    ..This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors...
  60. doi Molecular targeted treatment and radiation therapy for rectal cancer
    Friederike Marquardt
    Department of Radiation Therapy, University of Frankfurt Main, Germany
    Strahlenther Onkol 185:371-8. 2009
    ..An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols...
  61. doi Locally advanced rectal carcinoma treated with preoperative chemotherapy and radiation therapy: preliminary analysis of diffusion-weighted MR imaging for early detection of tumor histopathologic downstaging
    Ying Shi Sun
    Key laboratory of Carcinogenesis and Translational Research, Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    Radiology 254:170-8. 2010
    ....
  62. ncbi Diffusion MRI for prediction of response of rectal cancer to chemoradiation
    Andrzej Dzik-Jurasz
    UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
    Lancet 360:307-8. 2002
    ..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
  63. pmc Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy
    Marian Grade
    Department of General and Visceral Surgery, University Medicine, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    Cancer Genet Cytogenet 193:19-28. 2009
    ..This will require validation in a larger cohort of patients...
  64. ncbi The posterior approach for low retrorectal tumors in adults
    Nicolas Buchs
    Unit of Proctology, Department of Surgery, University Hospital of Geneva, 24, Rue Micheli du Crest, 1205 Geneva, Switzerland
    Int J Colorectal Dis 22:381-5. 2007
    ..The aim of this study is to evaluate early complete surgical resection by a perineal approach as the therapy-of-choice for tumors under the sacral promontory...
  65. doi Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer
    D Pettersson
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 97:580-7. 2010
    ..The present interim analysis assessed feasibility, compliance and complications after RT and surgery...
  66. pmc Addition of bevacizumab to XELOX induction therapy plus concomitant capecitabine-based chemoradiotherapy in magnetic resonance imaging-defined poor-prognosis locally advanced rectal cancer: the AVACROSS study
    Miguel Nogue
    Department of Oncology, Hospital General de Vic, C Francesc Pla El Vigatà, 1, 08500 Vic, Spain
    Oncologist 16:614-20. 2011
    ..The objective of the current study was to assess the efficacy and toxicity of adding bevacizumab to induction chemotherapy followed by preoperative bevacizumab-based chemoradiotherapy in patients with locally advanced rectal cancer...
  67. doi Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 53:1365-73. 2010
    ..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
  68. doi Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trials
    K Bujko
    Department of Radiotherapy, The Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
    Ann Oncol 21:1743-50. 2010
    ..To evaluate this discrepancy further, a systematic review of relevant randomised trials was undertaken...
  69. doi Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapy
    Brunella Barbaro
    Department of Bioimaging and Radiological Sciences, Catholic University, School of Medicine, Largo A Gemelli 1, 00168 Rome, Italy
    Radiographics 30:699-716. 2010
    ..Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.303095085/-/DC1...
  70. ncbi Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy
    Angelita Habr-Gama
    Department of Gastroenterology, University of Sao Paulo School of Medicine, and Hospital Alemão Oswaldo Cruz HAOC, Sao Paulo, Brazil
    J Gastrointest Surg 10:1319-28; discussion 1328-9. 2006
    ..Survival in these patients is significantly affected by systemic failure. Exclusive local failure occurs late after CRT completion and is frequently amenable to salvage therapy...
  71. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  72. ncbi Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer
    Sunil Krishnan
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 66:762-71. 2006
    ..The aim of this study was to determine the efficacy of capecitabine (Xeloda), an oral fluoropyrimidine, as a radiosensitizer in the neoadjuvant treatment of locally advanced rectal cancer (LARC)...
  73. pmc Neoadjuvant treatment response as an early response indicator for patients with rectal cancer
    In Ja Park
    The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Clin Oncol 30:1770-6. 2012
    ..The purpose of this study was to assess and compare oncologic outcomes associated with the degree of pathologic response after chemoradiotherapy...
  74. doi Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial
    Claus Rodel
    Department of Radiotherapy and Oncology, University of Frankfurt, Frankfurt, Germany
    Lancet Oncol 13:679-87. 2012
    ..With the aim of improving disease-free survival (DFS), this phase 3 study (CAO/ARO/AIO-04) integrated oxaliplatin into standard treatment...
  75. ncbi Associations between apoE genotype and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 26:1422-9. 2005
    ....
  76. ncbi Chemotherapy with preoperative radiotherapy in rectal cancer
    Jean Francois Bosset
    Department of Radiation Therapy, University of Franche Comte, Besancon, France
    N Engl J Med 355:1114-23. 2006
    ..Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer...
  77. doi Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2
    Jean Pierre Gerard
    Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
    J Clin Oncol 28:1638-44. 2010
    ..Neoadjuvant chemoradiotherapy is considered a standard approach for T3-4 M0 rectal cancer. In this situation, we compared neoadjuvant radiotherapy plus capecitabine with dose-intensified radiotherapy plus capecitabine and oxaliplatin...
  78. ncbi Preoperative staging of rectal cancer using magnetic resonance imaging with external phase-arrayed coils
    Giuseppe Gagliardi
    Department of Surgical Oncology, School of Medicine, Yale University, 333 Cedar St, New Haven, CT 06520, USA
    Arch Surg 137:447-51. 2002
    ..Rectal cancer can be accurately staged preoperatively by magnetic resonance imaging (MRI) with external phase-arrayed coils...
  79. doi Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectum
    Yumi Mashimo
    Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 23:218-21. 2008
    ..The aim of the present study was to clarify the clinical usefulness of a novel technique named endoscopic submucosal resection with a ligation device (ESMR-L) in a large number of rectal carcinoid tumors...
  80. ncbi Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinoma
    David E Stein
    Division of Colorectal Surgery, Department of Surgery, Jefferson Medical College, Philadelphia, PA, USA
    Dis Colon Rectum 46:448-53. 2003
    ..Our purpose was to determine whether a longer time interval between completion of therapy and resection increases tumor downstaging and affects perioperative morbidity...
  81. pmc Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex
    Robert S Krouse
    Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
    J Clin Oncol 27:4664-70. 2009
    ..Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL)...
  82. ncbi Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach
    C Eckmann
    Department of Surgery, Medical University Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Int J Colorectal Dis 19:128-33. 2004
    ..This study analyzed the results of a standardized approach in anastomotic leakage following low anterior resection for rectal cancer without performance of a protective ileostomy during the primary operation...
  83. ncbi Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II/III trials
    A Hartley
    Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
    Br J Radiol 78:934-8. 2005
    ..Important factors not considered in this analysis include the variability in pathological examination and in the time interval between CRT and surgery. In addition, the toxicity of the CRT regimens requires further investigation...
  84. ncbi Intensity-modulated radiotherapy in patients with locally advanced rectal cancer reduces volume of bowel treated to high dose levels
    M Teresa Guerrero Urbano
    Department of Clinical Oncology, Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
    Int J Radiat Oncol Biol Phys 65:907-16. 2006
    ..To investigate the potential for intensity-modulated radiotherapy (IMRT) to spare the bowel in rectal tumors...
  85. ncbi Does positron emission tomography change management in primary rectal cancer? A prospective assessment
    Alexander G Heriot
    Department of Surgery, St Vincent s Hospital, Melbourne, Australia
    Dis Colon Rectum 47:451-8. 2004
    ..This study therefore prospectively assesses the impact of position emission tomography scanning on the management of primary rectal cancer...
  86. pmc Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid
    K Birkenkamp-Demtroder
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Gut 54:374-84. 2005
    ..The aim of this study was to investigate differences in gene expression...
  87. pmc Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival
    Nam Kyu Kim
    Colorectal Cancer Clinic, Severance Hospital, Yonsei University Medical Center, Yonsei University College of Medicine, Seoul, Korea
    Ann Surg 244:1024-30. 2006
    ....
  88. doi An interval >7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer
    Hagit Tulchinsky
    Proctology Unit, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann Surg Oncol 15:2661-7. 2008
    ....
  89. doi Quality of life among five-year survivors after treatment for very low rectal cancer with or without a permanent abdominal stoma
    C Fucini
    Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery, University of Florence, Viale Morgagni, 85, 50134, Firenze, Italy
    Ann Surg Oncol 15:1099-106. 2008
    ....
  90. ncbi Inadvertent perforation during rectal cancer resection in Norway
    M T Eriksen
    Department of Surgery, Buskerud Hospital, Drammen, Norway
    Br J Surg 91:210-6. 2004
    ..The purpose of this study was to examine intraoperative perforation following the introduction of mesorectal excision as a standard surgical technique in Norway...
  91. ncbi A comparative clinical study of short-term results of laparoscopic surgery for rectal cancer during the learning curve
    Ivan Arteaga Gonzalez
    Department of Gastrointestinal Surgery, Hospital Universitario de Canarias HUC, Ofra, s n La Cuesta, 38320 La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain
    Int J Colorectal Dis 21:590-5. 2006
    ..The aim of this study was to assess the results of laparoscopic surgery for rectal carcinoma (LSRC) during the learning curve throughout the introduction of this technique at our medical center...
  92. ncbi Technique and long-term results of intersphincteric resection for low rectal cancer
    Rudolf Schiessel
    Department of Surgery, Danube Hospital SMZ Ost, Vienna, Austria
    Dis Colon Rectum 48:1858-65; discussion 1865-7. 2005
    ..This study was designed to evaluate the long-term results of this method focused on continence function and oncologic results...
  93. ncbi Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02
    N Wolmark
    N Wolmark, D L Wickerham, E R Fisher, B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP Operations Center, Pittsburgh, PA 15212, USA
    J Natl Cancer Inst 92:388-96. 2000
    ..This study was carried out to address this issue. An additional aim was to determine whether leucovorin (LV)-modulated 5-fluorouracil (5-FU) is superior to the combination of 5-FU, semustine, and vincristine (MOF) in men...
  94. ncbi Long-term results of intersphincteric resection for low rectal cancer
    Reza Chamlou
    Departments of Digestive Surgery, Hopital Saint Antoine AP HP, Universite Pierre et Marie Curie, Paris VI, Paris, France
    Ann Surg 246:916-21; discussion 921-2. 2007
    ..Thus, intersphincteric resection (ISR) has been proposed as an alternative to abdominoperineal resection for selected low rectal cancer...
  95. ncbi Risk of lymph node metastasis in T1 carcinoma of the colon and rectum
    Riccardo Nascimbeni
    Division of Colorectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dis Colon Rectum 45:200-6. 2002
    ..Several recent reports of high local recurrence and lymph node metastasis in T1 carcinoma of the rectum prompted us to study the risk factors for lymph node metastasis in these lesions...
  96. ncbi Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01
    B Fisher
    University of Pittsburgh, PA
    J Natl Cancer Inst 80:21-9. 1988
    ..The observed advantage was restricted to males. Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival...
  97. doi The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancer
    Maarten Lambrecht
    Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Leuven, Belgium
    Acta Oncol 49:956-63. 2010
    ..To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy (CRT) and diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for the prediction of pathological response (pCR) in rectal cancer patients...
  98. doi Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer
    Masaaki Ito
    Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Chiba, Japan
    Dis Colon Rectum 52:64-70. 2009
    ..The purpose of this study was to identify factors that have a negative impact on anal function after intersphincteric resection...
  99. pmc Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Ann Surg 239:34-42. 2004
    ..To clarify the preoperative parameters of the required distal margin that can be applied to the criteria of sphincter-preserving surgery in rectal cancer...
  100. doi Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
    Sigurd Folkvord
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
    Int J Radiat Oncol Biol Phys 78:555-62. 2010
    ..This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC)...
  101. doi A gene expression signature for chemoradiosensitivity of colorectal cancer cells
    Melanie Spitzner
    Department of General and Visceral Surgery, Georg August University, Gottingen, Germany
    Int J Radiat Oncol Biol Phys 78:1184-92. 2010
    ..However, tumor response to multimodal treatment has varied greatly, ranging from complete resistance to complete pathologic regression. The prediction of the response is, therefore, an important clinical need...

Research Grants19

  1. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  2. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  3. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  4. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  5. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  6. Folate, DNA Methylation and Breast Tumorigenesis
    Joshua Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. The Influence of Companions and Socio-Demographic Characteristics on Patients' In
    Susan Eggly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Anneclaire De Roos; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  9. Positron Emission Tomography in Prostate Cancer
    Farrokh Dehdashti; Fiscal Year: 2008
    ..PET may also contribute significant prognostic information that may affect the decision to administer early adjuvant therapy to delay or prevent recurrence. [unreadable] [unreadable]..
  10. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007
    ..With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both. ..
  11. Industrial Pollutants and Risk of Non-Hodgkins Lymphoma
    Anneclaire De Roos; Fiscal Year: 2006
    ..abstract_text> ..
  12. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2001
    ..abstract_text> ..
  13. Sleep Disturbances in People with Cancer and Caregivers
    Ann Berger; Fiscal Year: 2004
    ..abstract_text> ..
  14. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
    ..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
  15. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..Serum Se, GPx activity, lipid peroxides and oxidative DNA damage will be measured in relation to HCV and alcohol intake history. ..
  16. Replication Study of Breast Cancer Susceptibility Genes in Blacks
    Dezheng Huo; Fiscal Year: 2010
    ..This study will advance understanding the genetic risk factors for breast cancer in women of African descent and will be invaluable in developing novel prevention strategies in the future. ..
  17. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2006
    ..Statistical analyses include RM-ANOVA, generalized estimation equation methodology and multiple regression analysis. Results may inform development of clinical guidelines for fatigue management during adjuvant CT. ..
  18. Evaluation of Biliary Strictures by IDUS, DIA, and FISH
    Michael Levy; Fiscal Year: 2005
    ..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
  19. International Conference on Malignant Bowel Obstruction
    Robert Krouse; Fiscal Year: 2004
    ..Using MBO as a model, a consensus will be attained for methodological approaches and the implementation of palliative care research. ..