Genomes and Genes
Summary: Tumors or cancer of the RECTUM.
Publications294 found, 100 shown here
- The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detectionSheng Xiang Rao
Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
Eur J Radiol 65:299-303. 2008..To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone...
- A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapyG Lezoche
Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
Surg Endosc 22:352-8. 2008....
- Preoperative versus postoperative chemoradiotherapy for rectal cancerRolf Sauer
Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
N Engl J Med 351:1731-40. 2004..In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer...
- Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trialWillem van Gijn
Leiden University Medical Centre, Leiden, The Netherlands
Lancet Oncol 12:575-82. 2011..The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years...
- Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203Jean Pierre Gerard
Centre Antoine Lacassagne, Radiotherapy Department, Nice, France
J Clin Oncol 24:4620-5. 2006..In 1992, preoperative radiotherapy was considered in France as the standard treatment for T3-4 rectal cancers. The present randomized trial compares preoperative radiotherapy with chemoradiotherapy...
- Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2Jean Pierre Gerard
Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
J Clin Oncol 28:1638-44. 2010..Neoadjuvant chemoradiotherapy is considered a standard approach for T3-4 M0 rectal cancer. In this situation, we compared neoadjuvant radiotherapy plus capecitabine with dose-intensified radiotherapy plus capecitabine and oxaliplatin...
- The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinomaKoen C M J Peeters
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Ann Surg 246:693-701. 2007..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
- Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancerE Kapiteijn
Department of Surgery, Leiden University Medical Center, The Netherlands
N Engl J Med 345:638-46. 2001..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
- Chemotherapy with preoperative radiotherapy in rectal cancerJean Francois Bosset
Department of Radiation Therapy, University of Franche Comte, Besancon, France
N Engl J Med 355:1114-23. 2006..Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer...
- Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trialDavid Sebag-Montefiore
St James s University Hospital, Leeds, UK
Lancet 373:811-20. 2009..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
- Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapyH Birgisson
Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala, Uppsala, Sweden
Br J Surg 95:206-13. 2008..The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and to determine their relationship to preoperative radiation therapy...
- Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trialCarlo Aschele
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
J Clin Oncol 29:2773-80. 2011..To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer...
- Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient dataMonique Maas
Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands
Lancet Oncol 11:835-44. 2010..This study established whether patients with pCR have better long-term outcome than do those without pCR...
- Effective surgical adjuvant therapy for high-risk rectal carcinomaJ E Krook
Duluth Community Clinical Oncology Program, Minn
N Engl J Med 324:709-15. 1991..We designed a combination regimen to optimize the contribution of chemotherapy, decrease recurrence, and improve survival as compared with adjuvant radiation alone...
- Laparoscopic versus open surgery for rectal cancer: long-term oncologic resultsChristophe Laurent
Department of Colorectal Surgery, Saint Andre Hospital, University of Bordeaux, Bordeaux 33075, France
Ann Surg 250:54-61. 2009..The goal was to assess long-term oncologic outcome after laparoscopic versus open surgery for rectal cancer and to evaluate the impact of conversion...
- Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancerK Bujko
Department of Radiotherapy, Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
Br J Surg 93:1215-23. 2006..The aim of this study was to compare survival, local control and late toxicity in the two treatment groups...
- Epidemiology and management of liver metastases from colorectal cancerSylvain Manfredi
Registre Bourguignon des Cancers Digestifs, Faculte de Medecine, Dijon Cedex, France
Ann Surg 244:254-9. 2006..The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases...
- Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysisShandra Bipat
Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Radiology 232:773-83. 2004..To perform a meta-analysis to compare endoluminal ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging in rectal cancer staging...
- Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 yearsRolf Sauer
University of Erlangen, Erlangen, Germany
J Clin Oncol 30:1926-33. 2012..However, after a median follow-up of 46 months, no survival benefit could be shown. Here, we report long-term results with a median follow-up of 134 months...
- Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissectionMartin R Weiser
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Ann Surg 249:236-42. 2009....
- Circumferential resection margin as a prognostic factor in rectal cancerT E Bernstein
Department of Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Br J Surg 96:1348-57. 2009..This study examined the prognostic impact of the circumferential resection margin (CRM) in patients with rectal cancer treated by total mesorectal excision (TME) with or without radiotherapy...
- A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancerJulie A Cornish
Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, UK
Ann Surg Oncol 14:2056-68. 2007..The aim of this study was to compare QoL following abdominoperineal excision of rectum (APER) with that after anterior resection (AR) in patients with rectal cancer...
- Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancerM Caricato
Department of Surgery, Campus Bio Medico University, Via Longoni 47, 00155 Rome, Italy
Eur J Surg Oncol 33:724-8. 2007..The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor...
- Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trialCorrie A M Marijnen
Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Oncol 23:1847-58. 2005..This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 x 5 Gy)...
- Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective studyPatrick A Hein
Department of Radiotherapy and Radiooncology, University of Innsbruck, Innsbruck, Austria
Eur J Radiol 45:214-22. 2003..To evaluate the clinical value of diffusion-weighted magnetic resonance imaging (DW-MRI) to monitor response of primary carcinoma of the rectum to preoperative chemoradiation by measuring tumor apparent diffusion coefficient (ADC)...
- Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapyC Bengala
Division of Medical Oncology, Department of Oncology, Hematology and Respiratory Disease, University Hospital, University of Modena and Reggio Emilia, Via del Pozzo, 71, Modena 41100, Italy
Br J Cancer 103:1019-24. 2010..Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their prognostic significance in colorectal cancer patients is still unclear...
- COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancerM Buunen
Department of Surgery, Dalhousie University, QE II Health Sciences Center, Victoria Building Room 8 838, 1278 Tower Road, Halifax NSB3H2Y9, Canada
Dan Med Bull 56:89-91. 2009..Completion of inclusion is expected by the end of 2009. Trial registration: Clinicaltrials.gov, identifier: NCT00297791 (www.clinicaltrials.gov)...
- Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancerZ G Zhou
Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China
Surg Endosc 18:1211-5. 2004....
- KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapyJochen Gaedcke
Department of General and Visceral Surgery, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
Radiother Oncol 94:76-81. 2010..KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established...
- Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancerClaus Rodel
Department of Radiation Therapy, University of Erlangen, Universitatsstr 27, D 91054 Erlangen, Germany
J Clin Oncol 23:8688-96. 2005..We assessed the impact of tumor regression grading (TRG) and its value in correlation to established prognostic factors in a cohort of rectal carcinoma patients treated by preoperative chemoradiotherapy (CRT)...
- Long-term follow-up of preoperative pelvic radiation therapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04-01)Jong Hoon Lee
Department of Radiation Oncology, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Int J Radiat Oncol Biol Phys 84:955-61. 2012....
- Preoperative chemoradiotherapy (CRT) followed by laparoscopic surgery for rectal cancer: predictors of the tumor response and the long-term oncologic outcomesJong Hoon Lee
Department of Radiation Oncology, St Vincent s Hospital, The Catholic University of Korea, College of Medicine, Suwon, Korea
Int J Radiat Oncol Biol Phys 81:431-8. 2011..We have evaluated the predictors of a tumor response to chemoradiotherapy (CRT) and the long-term oncologic outcomes of preoperative CRT and laparoscopic surgery for patients who suffer from rectal cancer...
- Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancerJason M Samuelian
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, USA
Int J Radiat Oncol Biol Phys 82:1981-7. 2012..The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes...
- Risk factors for fecal incontinence after intersphincteric resection for rectal cancerQuentin Denost
Department of Digestive Surgery, CHU Bordeaux, Saint Andre Hospital, Universite Victor Segalen, Bordeaux, France
Dis Colon Rectum 54:963-8. 2011..Intersphincteric resection allows sphincter preservation in low rectal cancer but may have poor functional results, including frequent bowel movements, urgency, and incontinence...
- Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgeryJi Won Park
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
Int J Radiat Oncol Biol Phys 74:810-7. 2009..To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer...
- Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II studySun Young Kim
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
Int J Radiat Oncol Biol Phys 81:677-83. 2011..To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer...
- The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancerRodrigo O Perez
Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Dis Colon Rectum 52:1137-43. 2009..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
- Preoperative or postoperative therapy for stage II or III rectal cancer: an updated practice guidelineR K S Wong
Princess Margaret Hospital, University Health Network, Radiation Medicine Program, Toronto, Ontario, Canada
Clin Oncol (R Coll Radiol) 22:265-71. 2010..What is the role of postoperative radiotherapy and/or chemotherapy for patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy, in terms of improving survival and delaying local recurrence?..
- Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapyJanine M Davies
Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
Radiat Oncol 6:114. 2011..Our objective was to explore the relationships of KRAS and BRAF mutation status with p-AKT and p-ERK and outcomes in RC...
- Quality of life among five-year survivors after treatment for very low rectal cancer with or without a permanent abdominal stomaC Fucini
Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery, University of Florence, Viale Morgagni, 85, 50134, Firenze, Italy
Ann Surg Oncol 15:1099-106. 2008....
- Preoperative 3T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequenceJurgen J Futterer
Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
Eur J Radiol 65:66-71. 2008..The purpose of our study was to evaluate the image quality and diagnostic performance of two-dimensional (D) turbo spin echo (TSE) and 3D T2-weighted TSE MR imaging in local staging of rectal cancer at 3T...
- Locally advanced rectal carcinoma treated with preoperative chemotherapy and radiation therapy: preliminary analysis of diffusion-weighted MR imaging for early detection of tumor histopathologic downstagingYing Shi Sun
Key laboratory of Carcinogenesis and Translational Research, Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
Radiology 254:170-8. 2010....
- PIK3CA mutations predict local recurrences in rectal cancer patientsYouji He
Departments of Experimental Therapy, Pathology, and Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands
Clin Cancer Res 15:6956-62. 2009..In this study, we aim to determine the mutation frequencies of PIK3CA, KRAS, and BRAF and to investigate whether a mutation may be used as a prognostic parameter in rectal cancer patients...
- The posterior approach for low retrorectal tumors in adultsNicolas Buchs
Unit of Proctology, Department of Surgery, University Hospital of Geneva, 24, Rue Micheli du Crest, 1205 Geneva, Switzerland
Int J Colorectal Dis 22:381-5. 2007..The aim of this study is to evaluate early complete surgical resection by a perineal approach as the therapy-of-choice for tumors under the sacral promontory...
- Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sexRobert S Krouse
Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
J Clin Oncol 27:4664-70. 2009..Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL)...
- Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapyMarian Grade
Department of General and Visceral Surgery, University Medicine, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
Cancer Genet Cytogenet 193:19-28. 2009..This will require validation in a larger cohort of patients...
- Molecular targeted treatment and radiation therapy for rectal cancerFriederike Marquardt
Department of Radiation Therapy, University of Frankfurt Main, Germany
Strahlenther Onkol 185:371-8. 2009..An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols...
- Urinary dysfunction after rectal cancer treatment is mainly caused by surgeryM M Lange
Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
Br J Surg 95:1020-8. 2008..This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors...
- Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patientsVincenzo Valentini
Department of Radiotherapy, Catholic University of the Sacred Heart, Policlinico Universitario Agostino Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
Int J Radiat Oncol Biol Phys 53:664-74. 2002....
- Diffusion MRI for prediction of response of rectal cancer to chemoradiationAndrzej Dzik-Jurasz
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
Lancet 360:307-8. 2002..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
- Addition of bevacizumab to XELOX induction therapy plus concomitant capecitabine-based chemoradiotherapy in magnetic resonance imaging-defined poor-prognosis locally advanced rectal cancer: the AVACROSS studyMiguel Nogue
Department of Oncology, Hospital General de Vic, C Francesc Pla El Vigatà, 1, 08500 Vic, Spain
Oncologist 16:614-20. 2011..The objective of the current study was to assess the efficacy and toxicity of adding bevacizumab to induction chemotherapy followed by preoperative bevacizumab-based chemoradiotherapy in patients with locally advanced rectal cancer...
- Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resectionGarrett M Nash
Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Dis Colon Rectum 53:1365-73. 2010..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
- Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancerD Pettersson
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Br J Surg 97:580-7. 2010..The present interim analysis assessed feasibility, compliance and complications after RT and surgery...
- Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trialsK Bujko
Department of Radiotherapy, The Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
Ann Oncol 21:1743-50. 2010....
- Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapyBrunella Barbaro
Department of Bioimaging and Radiological Sciences, Catholic University, School of Medicine, Largo A Gemelli 1, 00168 Rome, Italy
Radiographics 30:699-716. 2010..Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.303095085/-/DC1...
- Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapyAngelita Habr-Gama
Department of Gastroenterology, University of Sao Paulo School of Medicine, and Hospital Alemão Oswaldo Cruz HAOC, Sao Paulo, Brazil
J Gastrointest Surg 10:1319-28; discussion 1328-9. 2006..Survival in these patients is significantly affected by systemic failure. Exclusive local failure occurs late after CRT completion and is frequently amenable to salvage therapy...
- Technique and long-term results of intersphincteric resection for low rectal cancerRudolf Schiessel
Department of Surgery, Danube Hospital SMZ Ost, Vienna, Austria
Dis Colon Rectum 48:1858-65; discussion 1865-7. 2005..This study was designed to evaluate the long-term results of this method focused on continence function and oncologic results...
- Inadvertent perforation during rectal cancer resection in NorwayM T Eriksen
Department of Surgery, Buskerud Hospital, Drammen, Norway
Br J Surg 91:210-6. 2004..The purpose of this study was to examine intraoperative perforation following the introduction of mesorectal excision as a standard surgical technique in Norway...
- Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02N Wolmark
N Wolmark, D L Wickerham, E R Fisher, B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP Operations Center, Pittsburgh, PA 15212, USA
J Natl Cancer Inst 92:388-96. 2000..This study was carried out to address this issue. An additional aim was to determine whether leucovorin (LV)-modulated 5-fluorouracil (5-FU) is superior to the combination of 5-FU, semustine, and vincristine (MOF) in men...
- A comparative clinical study of short-term results of laparoscopic surgery for rectal cancer during the learning curveIvan Arteaga Gonzalez
Department of Gastrointestinal Surgery, Hospital Universitario de Canarias HUC, Ofra, s n La Cuesta, 38320 La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain
Int J Colorectal Dis 21:590-5. 2006..The aim of this study was to assess the results of laparoscopic surgery for rectal carcinoma (LSRC) during the learning curve throughout the introduction of this technique at our medical center...
- Long-term results of intersphincteric resection for low rectal cancerReza Chamlou
Departments of Digestive Surgery, Hopital Saint Antoine AP HP, Universite Pierre et Marie Curie, Paris VI, Paris, France
Ann Surg 246:916-21; discussion 921-2. 2007..Thus, intersphincteric resection (ISR) has been proposed as an alternative to abdominoperineal resection for selected low rectal cancer...
- Risk of lymph node metastasis in T1 carcinoma of the colon and rectumRiccardo Nascimbeni
Division of Colorectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Dis Colon Rectum 45:200-6. 2002..Several recent reports of high local recurrence and lymph node metastasis in T1 carcinoma of the rectum prompted us to study the risk factors for lymph node metastasis in these lesions...
- Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01B Fisher
University of Pittsburgh, PA
J Natl Cancer Inst 80:21-9. 1988..The observed advantage was restricted to males. Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival...
- Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancerMasaaki Ito
Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Chiba, Japan
Dis Colon Rectum 52:64-70. 2009..The purpose of this study was to identify factors that have a negative impact on anal function after intersphincteric resection...
- Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancerHideki Ueno
Department of Surgery I, National Defense Medical College, Saitama, Japan
Ann Surg 239:34-42. 2004..To clarify the preoperative parameters of the required distal margin that can be applied to the criteria of sphincter-preserving surgery in rectal cancer...
- The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancerMaarten Lambrecht
Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Leuven, Belgium
Acta Oncol 49:956-63. 2010..To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy (CRT) and diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for the prediction of pathological response (pCR) in rectal cancer patients...
- Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profilingSigurd Folkvord
Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
Int J Radiat Oncol Biol Phys 78:555-62. 2010..This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC)...
- Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2)Vincenzo Valentini
Cattedra di Radioterapia, Universita Cattolica del Sacro Cuore, Policlinico Universitario A Gemelli, Largo Gemelli 8, Rome, Italy
Radiother Oncol 92:148-63. 2009....
- A gene expression signature for chemoradiosensitivity of colorectal cancer cellsMelanie Spitzner
Department of General and Visceral Surgery, Georg August University, Gottingen, Germany
Int J Radiat Oncol Biol Phys 78:1184-92. 2010..However, tumor response to multimodal treatment has varied greatly, ranging from complete resistance to complete pathologic regression. The prediction of the response is, therefore, an important clinical need...
- Local recurrence following total mesorectal excision with double-stapling anastomosis for rectal cancers: analysis of risk factorsWai Lun Law
Department of Surgery, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam Road, Hong Kong, Hong Kong
World J Surg 26:1272-6. 2002..A high local recurrence rate was associated with distal cancers (? 6 cm from the anal verge) with lymphovascular invasion. Adjuvant therapy for local control should be considered for this subgroup of patients...
- Definition and delineation of the clinical target volume for rectal cancerSarah Roels
Department of Radiotherapy, University Hospital Gasthuisberg, Leuven, Belgium
Int J Radiat Oncol Biol Phys 65:1129-42. 2006....
- Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trialPeter Matthiessen
Department of Surgery, Orebro University Hospital, Orebro, Sweden
Ann Surg 246:207-14. 2007....
- Curative potential of multimodality therapy for locally recurrent rectal cancerDieter Hahnloser
Division of Colon and Rectal Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Ann Surg 237:502-8. 2003..To assess the results of multimodality therapy for patients with recurrent rectal cancer and to analyze factors predictive of curative resection and prognostic for overall survival...
- Laparoscopic-assisted versus open abdominoperineal resection for low rectal cancer: a prospective randomized trialSimon S M Ng
Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Ann Surg Oncol 15:2418-25. 2008..Recurrence and survival data were also recorded and compared between the two groups...
- Impact of functional results on quality of life after rectal cancer surgeryJaana H Vironen
Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
Dis Colon Rectum 49:568-78. 2006..Quality of life is an important outcome measure that has to be considered when deciding treatment strategy for rectal cancer. The aim of this study was to find out the impact of surgery-related adverse effects on quality of life...
- Neoadjuvant therapy for rectal cancer: histologic response of the primary tumor predicts nodal statusThomas E Read
Division of Colon and Rectal Surgery, Western Pennsylvania Hospital Clinical Campus of Temple University School of Medicine, Pittsburgh, Pennsylvania 15224, USA
Dis Colon Rectum 47:825-31. 2004....
- Long-term results of the Lyons R90-01 randomized trial of preoperative radiotherapy with delayed surgery and its effect on sphincter-saving surgery in rectal cancerO Glehen
Department of Surgery, Centre Hospitalier Lyon Sud, Lyons, France
Br J Surg 90:996-8. 2003
- Liver resection for colorectal metastasesY Fong
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 15:938-46. 1997..The current study was performed to determine if liver resection for colorectal metastases is safe and effective and to evaluate predictors of outcome...
- Is T classification still correlated with lymph node status after preoperative chemoradiotherapy for rectal cancer?Duck Woo Kim
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
Cancer 106:1694-700. 2006..The current study investigated the correlation between tumor involvement in regional lymph nodes and rectal mural tumor status in patients who underwent preoperative CRT for rectal cancer...
- A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonographyFrancesco Stipa
Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, New York 10021, USA
Ann Surg Oncol 13:1047-53. 2006..However, the prognostic significance of pCR remains unclear...
- Preliminary results on the influence of chemoradiation on apparent diffusion coefficients of primary rectal carcinoma measured by magnetic resonance imagingChristian Kremser
Department of Radiology, University of Innsbruck, Austria
Strahlenther Onkol 179:641-9. 2003..To study changes of the apparent diffusion coefficient (ADC) measured by magnetic resonance imaging (MRI) in patients with primary rectal carcinoma during a course of combined chemoradiation...
- Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapyHanifa Bouzourene
Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Cancer 94:1121-30. 2002..Nevertheless, to the authors' knowledge few data are available regarding the histopathologic response to radiotherapy as assessed on surgical specimens as a potential predictive factor for outcome...
- Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancerD G Jayne
Section of Translational Anaesthesia and Surgery, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
Br J Surg 97:1638-45. 2010..The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open surgery for colorectal cancer. The results of the 5-year follow-up analysis are presented...
- Guidelines 2000 for colon and rectal cancer surgeryH Nelson
Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
J Natl Cancer Inst 93:583-96. 2001..The National Cancer Institute sponsored a panel of experts to systematically review current literature and to draft guidelines that provide uniform definitions, principles, and practices...
- Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancerNicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
J Clin Oncol 26:3517-22. 2008..Changing to an extended prone perineal dissection results in a more cylindrical specimen and should improve outcomes...
- Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cellsL Yang
Division of Oncology, Department of Clinical and Experiment Medicine, Linkoping University, S 581 85 Linkoping, Sweden
Oncogene 29:516-26. 2010..Interestingly, PPAR-beta seems to have a more important role in poorly metastatic cells than in highly metastatic ones...
- Sphincter-saving resection for all rectal carcinomas: the end of the 2-cm distal ruleEric Rullier
Department of Surgery, Saint Andre Hospital, Bordeaux, France
Ann Surg 241:465-9. 2005..To assess oncologic outcome of patients treated by conservative radical surgery for tumors below 5 cm from the anal verge...
- Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03Mark S Roh
National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
J Clin Oncol 27:5124-30. 2009..The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma...
- Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancerT Holm
Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
Br J Surg 94:232-8. 2007..The aim of this study was to report the technique and early experience of extended APR in a select cohort of patients...
- A population-based study on the management and outcome in patients with locally recurrent rectal cancerG Palmer
Department of Molecular Medicine and Surgery, Karolinska Institute, 171 76, Stockholm, Sweden
Ann Surg Oncol 14:447-54. 2007..The condition is difficult to cure and little is known on whether the prognosis for patients with locally recurrent tumours has changed over time. Few population-based studies have been performed...
- Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancerSang Min Yoon
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
Int J Radiat Oncol Biol Phys 69:1167-72. 2007..To identify pretreatment clinical parameters that could predict pathologic tumor response to preoperative chemoradiotherapy (CRT) for rectal cancer...
- Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancerMorten Braendengen
Departments of Medical Oncology and Surgery, Norwegian Radium Hospital, Ulleval University Hospital, Cancer Centre, Oslo, Norway
J Clin Oncol 26:3687-94. 2008..This trial investigated whether chemotherapy as part of a multidisciplinary treatment approach would improve downstaging, survival, and relapse rate...
- Laparoscopic versus open surgery for rectal cancer: a meta-analysisOmer Aziz
Department of Surgical Oncology and Technology, Imperial College London, St Mary s Hospital, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, United Kingdom
Ann Surg Oncol 13:413-24. 2006..This study used meta-analytical techniques to compare laparoscopic and open surgery as the primary treatment for patients with rectal cancer with regard to short-term and long-term outcomes...
- Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term resultsAngelita Habr-Gama
Colorectal Surgery Division, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Ann Surg 240:711-7; discussion 717-8. 2004..Report overall long-term results of stage 0 rectal cancer following neoadjuvant chemoradiation and compare long-term results between operative and nonoperative treatment...
- The impact of preoperative chemoradiotherapy on advanced low rectal cancerPing Sheng Kao
Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
J Surg Oncol 102:771-7. 2010..Preoperative chemoradiotherapy (CCRT) followed by radical resection is an option for advanced low rectal cancer. This study was aimed to clarify the impact of CCRT on patients' outcome...
- Could a wait and see policy be justified in T3/4 rectal cancers after chemo-radiotherapy?Robert Hughes
Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex HA6 2RN, UK
Acta Oncol 49:378-81. 2010..The present retrospective study aimed to determine whether similar rates of local disease control are seen in a UK cancer centre in patients with T3-4 tumours, who obtained a cCR after preoperative CRT, but did not undergo surgery...
- Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome?Angelita Habr-Gama
Habr Gama Research Institute, Sao Paulo, SP, Brazil
Int J Radiat Oncol Biol Phys 71:1181-8. 2008..The purpose of this study is to evaluate whether this interval has an impact on survival...
- Function after intersphincteric resection for low rectal cancer and its influence on quality of lifeG Barisic
First Surgical Clinic, Clinical Centre of Serbia, Belgrade, Serbia College for Sport and Health, Belgrade, Serbia
Colorectal Dis 13:638-43. 2011..The aim of the study was to investigate function and quality of life after different types of intersphincteric resection (ISR)...
- Combined modality therapy including intraoperative electron irradiation for locally recurrent colorectal cancerMichael G Haddock
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
Int J Radiat Oncol Biol Phys 79:143-50. 2011..To evaluate survival, relapse patterns, and prognostic factors in patients with colorectal cancer relapse treated with curative-intent therapy, including intraoperative electron radiation therapy (IOERT)...
- Preoperative treatment with capecitabine, bevacizumab and radiotherapy for primary locally advanced rectal cancer--a two stage phase II clinical trialGudrun Resch
Department of Internal Medicine IV, Klinikum Wels Grieskirchen, Austria
Radiother Oncol 102:10-3. 2012..Secondary endpoints were downstaging-rate and induction of complete pathological response...
- Bladder and sexual function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open techniqueD G Jayne
Academic Unit of Surgery, St James s University Hospital, Leeds, UK
Br J Surg 92:1124-32. 2005..Bladder and sexual dysfunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown...
- DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2002..abstract_text> ..
- Disparities in Breast Cancer: Development and Survival in Hispanic and NHW WomenMARTHA OR MARTY L SLATTERY; Fiscal Year: 2009..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
- Diet, Activity, and Lifestyle as a Risk Factor for Colorectal CancerMARTHA OR MARTY L SLATTERY; Fiscal Year: 2010..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- Disparities in Breast Cancer: Development and Survival in Hispanic and NHW WomenMARTHA OR MARTY L SLATTERY; Fiscal Year: 2010..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
- DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 1993..Methods have been developed to ensure coordination of study activities...
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 1999..We also will store DNA frpom tumor tissue so that as laboratory techniques for analyzing somatic gene mutations necome refined, the associations between dietary intake and other genes, such as APC and DCC, can be assessed in the future. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- Diet, Activity, and Lifestyle as a Risk Factor for Colorectal CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
- EST. INVESTIGATOR CAREER AWARD IN PREVENTION, CONTROL BEHAVIORAL & POPULATION RESNoel Weiss; Fiscal Year: 2006..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
- Timing of Rectal Cancer Response to ChemoradiationJulio Garcia Aguilar; Fiscal Year: 2009..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
- PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCERJose Guillem; Fiscal Year: 2001..abstract_text> ..
- Use of Geographic Variations to Estimate Effectiveness with Non-Randomized DataMary Beth Landrum; Fiscal Year: 2010..In addition, the methods developed will be applicable to a broad range of interventions for cancer and other diseases, providing a framework for future comparative effectiveness studies and ultimately changes in treatment guidelines. ..
- Radiation-induced signaling and treatment resistanceBERT O NEIL; Fiscal Year: 2007..The long-term goal of our research is to apply drugs that target tumor but not normal tissue in addition to radiation to improve the effectiveness of radiation on rectal cancer. ..
- Fatigue & Breast Cancer-A Behavioral Sleep InterventionAnn Berger; Fiscal Year: 2006..Statistical analyses include RM-ANOVA, generalized estimation equation methodology and multiple regression analysis. Results may inform development of clinical guidelines for fatigue management during adjuvant CT. ..
- Enhancing Colorectal Cancer Screening in Primary CareElectra D Paskett; Fiscal Year: 2010..If successful, this program can easily be adapted for use by primary care practices and clinics to improve CRC screening. ..
- Evaluation of Biliary Strictures by IDUS, DIA, and FISHMichael Levy; Fiscal Year: 2005..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
- Longitudinal Neuroimaging in Sturge-Weber SyndromeCsaba Juhasz; Fiscal Year: 2010..The results will introduce novel, more accurate diagnostic tests and also identify new therapeutic targets to improve the outcome of this often devastating disease. ..
- International Conference on Malignant Bowel ObstructionRobert Krouse; Fiscal Year: 2004..Using MBO as a model, a consensus will be attained for methodological approaches and the implementation of palliative care research. ..
- Replication Study of Breast Cancer Susceptibility Genes in BlacksDezheng Huo; Fiscal Year: 2009..This study will advance understanding the genetic risk factors for breast cancer in women of African descent and will be invaluable in developing novel prevention strategies in the future. ..
- HR-QOL in Colorectal Cancer Survivors with StomasRobert Krouse; Fiscal Year: 2006..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. ..
- HR-QOL in Colorectal Cancer Survivors with StomasRobert Krouse; Fiscal Year: 2009....