rectal neoplasms

Summary

Summary: Tumors or cancer of the RECTUM.

Top Publications

  1. ncbi The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection
    Sheng Xiang Rao
    Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
    Eur J Radiol 65:299-303. 2008
  2. ncbi A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy
    G Lezoche
    Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
    Surg Endosc 22:352-8. 2008
  3. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
  4. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
    Willem van Gijn
    Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 12:575-82. 2011
  5. ncbi Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203
    Jean Pierre Gerard
    Centre Antoine Lacassagne, Radiotherapy Department, Nice, France
    J Clin Oncol 24:4620-5. 2006
  6. ncbi Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2
    Jean Pierre Gerard
    Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
    J Clin Oncol 28:1638-44. 2010
  7. ncbi The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
  8. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
  9. ncbi Chemotherapy with preoperative radiotherapy in rectal cancer
    Jean Francois Bosset
    Department of Radiation Therapy, University of Franche Comte, Besancon, France
    N Engl J Med 355:1114-23. 2006
  10. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009

Research Grants

  1. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
  2. COLORECTAL CANCER AMONG CALIFORNIA MORMONS
    Lester Breslow; Fiscal Year: 1980
  3. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2009
  4. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1991
  5. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
  6. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2008
  7. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2005
  8. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2004
  9. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2000
  10. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003

Detail Information

Publications294 found, 100 shown here

  1. ncbi The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection
    Sheng Xiang Rao
    Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People s Republic of China
    Eur J Radiol 65:299-303. 2008
    ..To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone...
  2. ncbi A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy
    G Lezoche
    Department of Surgery Paride Stefanini, II Clinica Chirurgica, University of Rome La Sapienza, Viale del Policlinico, 00161, Rome, Italy
    Surg Endosc 22:352-8. 2008
    ....
  3. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
    ..In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer...
  4. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
    Willem van Gijn
    Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 12:575-82. 2011
    ..The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years...
  5. ncbi Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203
    Jean Pierre Gerard
    Centre Antoine Lacassagne, Radiotherapy Department, Nice, France
    J Clin Oncol 24:4620-5. 2006
    ..In 1992, preoperative radiotherapy was considered in France as the standard treatment for T3-4 rectal cancers. The present randomized trial compares preoperative radiotherapy with chemoradiotherapy...
  6. ncbi Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2
    Jean Pierre Gerard
    Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
    J Clin Oncol 28:1638-44. 2010
    ..Neoadjuvant chemoradiotherapy is considered a standard approach for T3-4 M0 rectal cancer. In this situation, we compared neoadjuvant radiotherapy plus capecitabine with dose-intensified radiotherapy plus capecitabine and oxaliplatin...
  7. ncbi The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
    ..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
  8. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  9. ncbi Chemotherapy with preoperative radiotherapy in rectal cancer
    Jean Francois Bosset
    Department of Radiation Therapy, University of Franche Comte, Besancon, France
    N Engl J Med 355:1114-23. 2006
    ..Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer...
  10. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009
    ..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
  11. ncbi Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy
    H Birgisson
    Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala, Uppsala, Sweden
    Br J Surg 95:206-13. 2008
    ..The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and to determine their relationship to preoperative radiation therapy...
  12. doi Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial
    Carlo Aschele
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Clin Oncol 29:2773-80. 2011
    ..To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer...
  13. ncbi Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
    Monique Maas
    Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands
    Lancet Oncol 11:835-44. 2010
    ..This study established whether patients with pCR have better long-term outcome than do those without pCR...
  14. ncbi Effective surgical adjuvant therapy for high-risk rectal carcinoma
    J E Krook
    Duluth Community Clinical Oncology Program, Minn
    N Engl J Med 324:709-15. 1991
    ..We designed a combination regimen to optimize the contribution of chemotherapy, decrease recurrence, and improve survival as compared with adjuvant radiation alone...
  15. doi Laparoscopic versus open surgery for rectal cancer: long-term oncologic results
    Christophe Laurent
    Department of Colorectal Surgery, Saint Andre Hospital, University of Bordeaux, Bordeaux 33075, France
    Ann Surg 250:54-61. 2009
    ..The goal was to assess long-term oncologic outcome after laparoscopic versus open surgery for rectal cancer and to evaluate the impact of conversion...
  16. ncbi Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
    K Bujko
    Department of Radiotherapy, Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
    Br J Surg 93:1215-23. 2006
    ..The aim of this study was to compare survival, local control and late toxicity in the two treatment groups...
  17. pmc Epidemiology and management of liver metastases from colorectal cancer
    Sylvain Manfredi
    Registre Bourguignon des Cancers Digestifs, Faculte de Medecine, Dijon Cedex, France
    Ann Surg 244:254-9. 2006
    ..The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases...
  18. ncbi Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis
    Shandra Bipat
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 232:773-83. 2004
    ..To perform a meta-analysis to compare endoluminal ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging in rectal cancer staging...
  19. ncbi Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years
    Rolf Sauer
    University of Erlangen, Erlangen, Germany
    J Clin Oncol 30:1926-33. 2012
    ..However, after a median follow-up of 46 months, no survival benefit could be shown. Here, we report long-term results with a median follow-up of 134 months...
  20. doi Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 249:236-42. 2009
    ....
  21. ncbi Circumferential resection margin as a prognostic factor in rectal cancer
    T E Bernstein
    Department of Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Br J Surg 96:1348-57. 2009
    ..This study examined the prognostic impact of the circumferential resection margin (CRM) in patients with rectal cancer treated by total mesorectal excision (TME) with or without radiotherapy...
  22. ncbi A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer
    Julie A Cornish
    Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, UK
    Ann Surg Oncol 14:2056-68. 2007
    ..The aim of this study was to compare QoL following abdominoperineal excision of rectum (APER) with that after anterior resection (AR) in patients with rectal cancer...
  23. ncbi Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer
    M Caricato
    Department of Surgery, Campus Bio Medico University, Via Longoni 47, 00155 Rome, Italy
    Eur J Surg Oncol 33:724-8. 2007
    ..The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor...
  24. ncbi Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:1847-58. 2005
    ..This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 x 5 Gy)...
  25. ncbi Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective study
    Patrick A Hein
    Department of Radiotherapy and Radiooncology, University of Innsbruck, Innsbruck, Austria
    Eur J Radiol 45:214-22. 2003
    ..To evaluate the clinical value of diffusion-weighted magnetic resonance imaging (DW-MRI) to monitor response of primary carcinoma of the rectum to preoperative chemoradiation by measuring tumor apparent diffusion coefficient (ADC)...
  26. pmc Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy
    C Bengala
    Division of Medical Oncology, Department of Oncology, Hematology and Respiratory Disease, University Hospital, University of Modena and Reggio Emilia, Via del Pozzo, 71, Modena 41100, Italy
    Br J Cancer 103:1019-24. 2010
    ..Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their prognostic significance in colorectal cancer patients is still unclear...
  27. ncbi COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancer
    M Buunen
    Department of Surgery, Dalhousie University, QE II Health Sciences Center, Victoria Building Room 8 838, 1278 Tower Road, Halifax NSB3H2Y9, Canada
    Dan Med Bull 56:89-91. 2009
    ..Completion of inclusion is expected by the end of 2009. Trial registration: Clinicaltrials.gov, identifier: NCT00297791 (www.clinicaltrials.gov)...
  28. ncbi Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancer
    Z G Zhou
    Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China
    Surg Endosc 18:1211-5. 2004
    ....
  29. doi KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy
    Jochen Gaedcke
    Department of General and Visceral Surgery, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Radiother Oncol 94:76-81. 2010
    ..KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established...
  30. ncbi Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    Claus Rodel
    Department of Radiation Therapy, University of Erlangen, Universitatsstr 27, D 91054 Erlangen, Germany
    J Clin Oncol 23:8688-96. 2005
    ..We assessed the impact of tumor regression grading (TRG) and its value in correlation to established prognostic factors in a cohort of rectal carcinoma patients treated by preoperative chemoradiotherapy (CRT)...
  31. doi Long-term follow-up of preoperative pelvic radiation therapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04-01)
    Jong Hoon Lee
    Department of Radiation Oncology, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 84:955-61. 2012
    ....
  32. doi Preoperative chemoradiotherapy (CRT) followed by laparoscopic surgery for rectal cancer: predictors of the tumor response and the long-term oncologic outcomes
    Jong Hoon Lee
    Department of Radiation Oncology, St Vincent s Hospital, The Catholic University of Korea, College of Medicine, Suwon, Korea
    Int J Radiat Oncol Biol Phys 81:431-8. 2011
    ..We have evaluated the predictors of a tumor response to chemoradiotherapy (CRT) and the long-term oncologic outcomes of preoperative CRT and laparoscopic surgery for patients who suffer from rectal cancer...
  33. doi Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancer
    Jason M Samuelian
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, USA
    Int J Radiat Oncol Biol Phys 82:1981-7. 2012
    ..The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes...
  34. doi Risk factors for fecal incontinence after intersphincteric resection for rectal cancer
    Quentin Denost
    Department of Digestive Surgery, CHU Bordeaux, Saint Andre Hospital, Universite Victor Segalen, Bordeaux, France
    Dis Colon Rectum 54:963-8. 2011
    ..Intersphincteric resection allows sphincter preservation in low rectal cancer but may have poor functional results, including frequent bowel movements, urgency, and incontinence...
  35. doi Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery
    Ji Won Park
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
    Int J Radiat Oncol Biol Phys 74:810-7. 2009
    ..To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer...
  36. doi Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study
    Sun Young Kim
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Int J Radiat Oncol Biol Phys 81:677-83. 2011
    ..To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer...
  37. doi The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancer
    Rodrigo O Perez
    Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Dis Colon Rectum 52:1137-43. 2009
    ..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
  38. doi Preoperative or postoperative therapy for stage II or III rectal cancer: an updated practice guideline
    R K S Wong
    Princess Margaret Hospital, University Health Network, Radiation Medicine Program, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 22:265-71. 2010
    ..What is the role of postoperative radiotherapy and/or chemotherapy for patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy, in terms of improving survival and delaying local recurrence?..
  39. pmc Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy
    Janine M Davies
    Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
    Radiat Oncol 6:114. 2011
    ..Our objective was to explore the relationships of KRAS and BRAF mutation status with p-AKT and p-ERK and outcomes in RC...
  40. doi Quality of life among five-year survivors after treatment for very low rectal cancer with or without a permanent abdominal stoma
    C Fucini
    Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery, University of Florence, Viale Morgagni, 85, 50134, Firenze, Italy
    Ann Surg Oncol 15:1099-106. 2008
    ....
  41. doi Preoperative 3T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequence
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Radiol 65:66-71. 2008
    ..The purpose of our study was to evaluate the image quality and diagnostic performance of two-dimensional (D) turbo spin echo (TSE) and 3D T2-weighted TSE MR imaging in local staging of rectal cancer at 3T...
  42. doi Locally advanced rectal carcinoma treated with preoperative chemotherapy and radiation therapy: preliminary analysis of diffusion-weighted MR imaging for early detection of tumor histopathologic downstaging
    Ying Shi Sun
    Key laboratory of Carcinogenesis and Translational Research, Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    Radiology 254:170-8. 2010
    ....
  43. doi PIK3CA mutations predict local recurrences in rectal cancer patients
    Youji He
    Departments of Experimental Therapy, Pathology, and Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Clin Cancer Res 15:6956-62. 2009
    ..In this study, we aim to determine the mutation frequencies of PIK3CA, KRAS, and BRAF and to investigate whether a mutation may be used as a prognostic parameter in rectal cancer patients...
  44. ncbi The posterior approach for low retrorectal tumors in adults
    Nicolas Buchs
    Unit of Proctology, Department of Surgery, University Hospital of Geneva, 24, Rue Micheli du Crest, 1205 Geneva, Switzerland
    Int J Colorectal Dis 22:381-5. 2007
    ..The aim of this study is to evaluate early complete surgical resection by a perineal approach as the therapy-of-choice for tumors under the sacral promontory...
  45. pmc Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex
    Robert S Krouse
    Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
    J Clin Oncol 27:4664-70. 2009
    ..Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL)...
  46. pmc Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy
    Marian Grade
    Department of General and Visceral Surgery, University Medicine, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    Cancer Genet Cytogenet 193:19-28. 2009
    ..This will require validation in a larger cohort of patients...
  47. doi Molecular targeted treatment and radiation therapy for rectal cancer
    Friederike Marquardt
    Department of Radiation Therapy, University of Frankfurt Main, Germany
    Strahlenther Onkol 185:371-8. 2009
    ..An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols...
  48. doi Urinary dysfunction after rectal cancer treatment is mainly caused by surgery
    M M Lange
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 95:1020-8. 2008
    ..This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors...
  49. ncbi Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients
    Vincenzo Valentini
    Department of Radiotherapy, Catholic University of the Sacred Heart, Policlinico Universitario Agostino Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
    Int J Radiat Oncol Biol Phys 53:664-74. 2002
    ....
  50. ncbi Diffusion MRI for prediction of response of rectal cancer to chemoradiation
    Andrzej Dzik-Jurasz
    UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
    Lancet 360:307-8. 2002
    ..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
  51. pmc Addition of bevacizumab to XELOX induction therapy plus concomitant capecitabine-based chemoradiotherapy in magnetic resonance imaging-defined poor-prognosis locally advanced rectal cancer: the AVACROSS study
    Miguel Nogue
    Department of Oncology, Hospital General de Vic, C Francesc Pla El Vigatà, 1, 08500 Vic, Spain
    Oncologist 16:614-20. 2011
    ..The objective of the current study was to assess the efficacy and toxicity of adding bevacizumab to induction chemotherapy followed by preoperative bevacizumab-based chemoradiotherapy in patients with locally advanced rectal cancer...
  52. doi Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 53:1365-73. 2010
    ..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
  53. ncbi Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer
    D Pettersson
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 97:580-7. 2010
    ..The present interim analysis assessed feasibility, compliance and complications after RT and surgery...
  54. ncbi Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trials
    K Bujko
    Department of Radiotherapy, The Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
    Ann Oncol 21:1743-50. 2010
    ..To evaluate this discrepancy further, a systematic review of relevant randomised trials was undertaken...
  55. ncbi Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapy
    Brunella Barbaro
    Department of Bioimaging and Radiological Sciences, Catholic University, School of Medicine, Largo A Gemelli 1, 00168 Rome, Italy
    Radiographics 30:699-716. 2010
    ..Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.303095085/-/DC1...
  56. ncbi Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy
    Angelita Habr-Gama
    Department of Gastroenterology, University of Sao Paulo School of Medicine, and Hospital Alemão Oswaldo Cruz HAOC, Sao Paulo, Brazil
    J Gastrointest Surg 10:1319-28; discussion 1328-9. 2006
    ..Survival in these patients is significantly affected by systemic failure. Exclusive local failure occurs late after CRT completion and is frequently amenable to salvage therapy...
  57. ncbi Technique and long-term results of intersphincteric resection for low rectal cancer
    Rudolf Schiessel
    Department of Surgery, Danube Hospital SMZ Ost, Vienna, Austria
    Dis Colon Rectum 48:1858-65; discussion 1865-7. 2005
    ..This study was designed to evaluate the long-term results of this method focused on continence function and oncologic results...
  58. ncbi Inadvertent perforation during rectal cancer resection in Norway
    M T Eriksen
    Department of Surgery, Buskerud Hospital, Drammen, Norway
    Br J Surg 91:210-6. 2004
    ..The purpose of this study was to examine intraoperative perforation following the introduction of mesorectal excision as a standard surgical technique in Norway...
  59. ncbi Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02
    N Wolmark
    N Wolmark, D L Wickerham, E R Fisher, B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP Operations Center, Pittsburgh, PA 15212, USA
    J Natl Cancer Inst 92:388-96. 2000
    ..This study was carried out to address this issue. An additional aim was to determine whether leucovorin (LV)-modulated 5-fluorouracil (5-FU) is superior to the combination of 5-FU, semustine, and vincristine (MOF) in men...
  60. ncbi A comparative clinical study of short-term results of laparoscopic surgery for rectal cancer during the learning curve
    Ivan Arteaga Gonzalez
    Department of Gastrointestinal Surgery, Hospital Universitario de Canarias HUC, Ofra, s n La Cuesta, 38320 La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain
    Int J Colorectal Dis 21:590-5. 2006
    ..The aim of this study was to assess the results of laparoscopic surgery for rectal carcinoma (LSRC) during the learning curve throughout the introduction of this technique at our medical center...
  61. ncbi Long-term results of intersphincteric resection for low rectal cancer
    Reza Chamlou
    Departments of Digestive Surgery, Hopital Saint Antoine AP HP, Universite Pierre et Marie Curie, Paris VI, Paris, France
    Ann Surg 246:916-21; discussion 921-2. 2007
    ..Thus, intersphincteric resection (ISR) has been proposed as an alternative to abdominoperineal resection for selected low rectal cancer...
  62. ncbi Risk of lymph node metastasis in T1 carcinoma of the colon and rectum
    Riccardo Nascimbeni
    Division of Colorectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dis Colon Rectum 45:200-6. 2002
    ..Several recent reports of high local recurrence and lymph node metastasis in T1 carcinoma of the rectum prompted us to study the risk factors for lymph node metastasis in these lesions...
  63. ncbi Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01
    B Fisher
    University of Pittsburgh, PA
    J Natl Cancer Inst 80:21-9. 1988
    ..The observed advantage was restricted to males. Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival...
  64. doi Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer
    Masaaki Ito
    Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Chiba, Japan
    Dis Colon Rectum 52:64-70. 2009
    ..The purpose of this study was to identify factors that have a negative impact on anal function after intersphincteric resection...
  65. pmc Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Ann Surg 239:34-42. 2004
    ..To clarify the preoperative parameters of the required distal margin that can be applied to the criteria of sphincter-preserving surgery in rectal cancer...
  66. ncbi The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancer
    Maarten Lambrecht
    Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Leuven, Belgium
    Acta Oncol 49:956-63. 2010
    ..To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy (CRT) and diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for the prediction of pathological response (pCR) in rectal cancer patients...
  67. ncbi Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
    Sigurd Folkvord
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
    Int J Radiat Oncol Biol Phys 78:555-62. 2010
    ..This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC)...
  68. ncbi Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2)
    Vincenzo Valentini
    Cattedra di Radioterapia, Universita Cattolica del Sacro Cuore, Policlinico Universitario A Gemelli, Largo Gemelli 8, Rome, Italy
    Radiother Oncol 92:148-63. 2009
    ....
  69. doi A gene expression signature for chemoradiosensitivity of colorectal cancer cells
    Melanie Spitzner
    Department of General and Visceral Surgery, Georg August University, Gottingen, Germany
    Int J Radiat Oncol Biol Phys 78:1184-92. 2010
    ..However, tumor response to multimodal treatment has varied greatly, ranging from complete resistance to complete pathologic regression. The prediction of the response is, therefore, an important clinical need...
  70. ncbi Local recurrence following total mesorectal excision with double-stapling anastomosis for rectal cancers: analysis of risk factors
    Wai Lun Law
    Department of Surgery, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam Road, Hong Kong, Hong Kong
    World J Surg 26:1272-6. 2002
    ..A high local recurrence rate was associated with distal cancers (? 6 cm from the anal verge) with lymphovascular invasion. Adjuvant therapy for local control should be considered for this subgroup of patients...
  71. ncbi Definition and delineation of the clinical target volume for rectal cancer
    Sarah Roels
    Department of Radiotherapy, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 65:1129-42. 2006
    ....
  72. pmc Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial
    Peter Matthiessen
    Department of Surgery, Orebro University Hospital, Orebro, Sweden
    Ann Surg 246:207-14. 2007
    ....
  73. pmc Curative potential of multimodality therapy for locally recurrent rectal cancer
    Dieter Hahnloser
    Division of Colon and Rectal Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Surg 237:502-8. 2003
    ..To assess the results of multimodality therapy for patients with recurrent rectal cancer and to analyze factors predictive of curative resection and prognostic for overall survival...
  74. ncbi Laparoscopic-assisted versus open abdominoperineal resection for low rectal cancer: a prospective randomized trial
    Simon S M Ng
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Ann Surg Oncol 15:2418-25. 2008
    ..Recurrence and survival data were also recorded and compared between the two groups...
  75. ncbi Impact of functional results on quality of life after rectal cancer surgery
    Jaana H Vironen
    Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
    Dis Colon Rectum 49:568-78. 2006
    ..Quality of life is an important outcome measure that has to be considered when deciding treatment strategy for rectal cancer. The aim of this study was to find out the impact of surgery-related adverse effects on quality of life...
  76. ncbi Neoadjuvant therapy for rectal cancer: histologic response of the primary tumor predicts nodal status
    Thomas E Read
    Division of Colon and Rectal Surgery, Western Pennsylvania Hospital Clinical Campus of Temple University School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Dis Colon Rectum 47:825-31. 2004
    ....
  77. ncbi Long-term results of the Lyons R90-01 randomized trial of preoperative radiotherapy with delayed surgery and its effect on sphincter-saving surgery in rectal cancer
    O Glehen
    Department of Surgery, Centre Hospitalier Lyon Sud, Lyons, France
    Br J Surg 90:996-8. 2003
  78. ncbi Liver resection for colorectal metastases
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 15:938-46. 1997
    ..The current study was performed to determine if liver resection for colorectal metastases is safe and effective and to evaluate predictors of outcome...
  79. ncbi Is T classification still correlated with lymph node status after preoperative chemoradiotherapy for rectal cancer?
    Duck Woo Kim
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Cancer 106:1694-700. 2006
    ..The current study investigated the correlation between tumor involvement in regional lymph nodes and rectal mural tumor status in patients who underwent preoperative CRT for rectal cancer...
  80. ncbi A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography
    Francesco Stipa
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, New York 10021, USA
    Ann Surg Oncol 13:1047-53. 2006
    ..However, the prognostic significance of pCR remains unclear...
  81. ncbi Preliminary results on the influence of chemoradiation on apparent diffusion coefficients of primary rectal carcinoma measured by magnetic resonance imaging
    Christian Kremser
    Department of Radiology, University of Innsbruck, Austria
    Strahlenther Onkol 179:641-9. 2003
    ..To study changes of the apparent diffusion coefficient (ADC) measured by magnetic resonance imaging (MRI) in patients with primary rectal carcinoma during a course of combined chemoradiation...
  82. ncbi Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cancer 94:1121-30. 2002
    ..Nevertheless, to the authors' knowledge few data are available regarding the histopathologic response to radiotherapy as assessed on surgical specimens as a potential predictive factor for outcome...
  83. ncbi Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer
    D G Jayne
    Section of Translational Anaesthesia and Surgery, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Br J Surg 97:1638-45. 2010
    ..The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open surgery for colorectal cancer. The results of the 5-year follow-up analysis are presented...
  84. ncbi Guidelines 2000 for colon and rectal cancer surgery
    H Nelson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Natl Cancer Inst 93:583-96. 2001
    ..The National Cancer Institute sponsored a panel of experts to systematically review current literature and to draft guidelines that provide uniform definitions, principles, and practices...
  85. doi Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer
    Nicholas P West
    Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
    J Clin Oncol 26:3517-22. 2008
    ..Changing to an extended prone perineal dissection results in a more cylindrical specimen and should improve outcomes...
  86. doi Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells
    L Yang
    Division of Oncology, Department of Clinical and Experiment Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Oncogene 29:516-26. 2010
    ..Interestingly, PPAR-beta seems to have a more important role in poorly metastatic cells than in highly metastatic ones...
  87. pmc Sphincter-saving resection for all rectal carcinomas: the end of the 2-cm distal rule
    Eric Rullier
    Department of Surgery, Saint Andre Hospital, Bordeaux, France
    Ann Surg 241:465-9. 2005
    ..To assess oncologic outcome of patients treated by conservative radical surgery for tumors below 5 cm from the anal verge...
  88. pmc Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03
    Mark S Roh
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
    J Clin Oncol 27:5124-30. 2009
    ..The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma...
  89. ncbi Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer
    T Holm
    Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
    Br J Surg 94:232-8. 2007
    ..The aim of this study was to report the technique and early experience of extended APR in a select cohort of patients...
  90. ncbi A population-based study on the management and outcome in patients with locally recurrent rectal cancer
    G Palmer
    Department of Molecular Medicine and Surgery, Karolinska Institute, 171 76, Stockholm, Sweden
    Ann Surg Oncol 14:447-54. 2007
    ..The condition is difficult to cure and little is known on whether the prognosis for patients with locally recurrent tumours has changed over time. Few population-based studies have been performed...
  91. ncbi Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer
    Sang Min Yoon
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 69:1167-72. 2007
    ..To identify pretreatment clinical parameters that could predict pathologic tumor response to preoperative chemoradiotherapy (CRT) for rectal cancer...
  92. ncbi Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer
    Morten Braendengen
    Departments of Medical Oncology and Surgery, Norwegian Radium Hospital, Ulleval University Hospital, Cancer Centre, Oslo, Norway
    J Clin Oncol 26:3687-94. 2008
    ..This trial investigated whether chemotherapy as part of a multidisciplinary treatment approach would improve downstaging, survival, and relapse rate...
  93. ncbi Laparoscopic versus open surgery for rectal cancer: a meta-analysis
    Omer Aziz
    Department of Surgical Oncology and Technology, Imperial College London, St Mary s Hospital, 10th Floor QEQM Wing, Praed Street, London, W2 1NY, United Kingdom
    Ann Surg Oncol 13:413-24. 2006
    ..This study used meta-analytical techniques to compare laparoscopic and open surgery as the primary treatment for patients with rectal cancer with regard to short-term and long-term outcomes...
  94. pmc Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results
    Angelita Habr-Gama
    Colorectal Surgery Division, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Ann Surg 240:711-7; discussion 717-8. 2004
    ..Report overall long-term results of stage 0 rectal cancer following neoadjuvant chemoradiation and compare long-term results between operative and nonoperative treatment...
  95. doi The impact of preoperative chemoradiotherapy on advanced low rectal cancer
    Ping Sheng Kao
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    J Surg Oncol 102:771-7. 2010
    ..Preoperative chemoradiotherapy (CCRT) followed by radical resection is an option for advanced low rectal cancer. This study was aimed to clarify the impact of CCRT on patients' outcome...
  96. doi Could a wait and see policy be justified in T3/4 rectal cancers after chemo-radiotherapy?
    Robert Hughes
    Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex HA6 2RN, UK
    Acta Oncol 49:378-81. 2010
    ..The present retrospective study aimed to determine whether similar rates of local disease control are seen in a UK cancer centre in patients with T3-4 tumours, who obtained a cCR after preoperative CRT, but did not undergo surgery...
  97. ncbi Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome?
    Angelita Habr-Gama
    Habr Gama Research Institute, Sao Paulo, SP, Brazil
    Int J Radiat Oncol Biol Phys 71:1181-8. 2008
    ..The purpose of this study is to evaluate whether this interval has an impact on survival...
  98. doi Function after intersphincteric resection for low rectal cancer and its influence on quality of life
    G Barisic
    First Surgical Clinic, Clinical Centre of Serbia, Belgrade, Serbia College for Sport and Health, Belgrade, Serbia
    Colorectal Dis 13:638-43. 2011
    ..The aim of the study was to investigate function and quality of life after different types of intersphincteric resection (ISR)...
  99. doi Combined modality therapy including intraoperative electron irradiation for locally recurrent colorectal cancer
    Michael G Haddock
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 79:143-50. 2011
    ..To evaluate survival, relapse patterns, and prognostic factors in patients with colorectal cancer relapse treated with curative-intent therapy, including intraoperative electron radiation therapy (IOERT)...
  100. doi Preoperative treatment with capecitabine, bevacizumab and radiotherapy for primary locally advanced rectal cancer--a two stage phase II clinical trial
    Gudrun Resch
    Department of Internal Medicine IV, Klinikum Wels Grieskirchen, Austria
    Radiother Oncol 102:10-3. 2012
    ..Secondary endpoints were downstaging-rate and induction of complete pathological response...
  101. ncbi Bladder and sexual function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique
    D G Jayne
    Academic Unit of Surgery, St James s University Hospital, Leeds, UK
    Br J Surg 92:1124-32. 2005
    ..Bladder and sexual dysfunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown...

Research Grants79

  1. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..abstract_text> ..
  2. COLORECTAL CANCER AMONG CALIFORNIA MORMONS
    Lester Breslow; Fiscal Year: 1980
    ..The above analyses should yield new understanding of the etiology and prevention of large bowel cancer in the United States. ..
  3. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2009
    ..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
  4. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1991
    ..Methods have been developed to ensure coordination of study activities...
  5. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  6. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2008
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  7. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2005
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  8. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2004
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  9. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2000
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  10. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  11. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  12. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2001
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  13. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2005
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  14. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  15. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  16. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
    ..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
  17. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  18. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1993
    ..Methods have been developed to ensure coordination of study activities...
  19. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
    ..We also will store DNA frpom tumor tissue so that as laboratory techniques for analyzing somatic gene mutations necome refined, the associations between dietary intake and other genes, such as APC and DCC, can be assessed in the future. ..
  20. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  21. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  22. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2005
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  23. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  24. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  25. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2001
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  26. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  27. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2001
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  28. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  29. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1992
    ..Methods have been developed to ensure coordination of study activities...
  30. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  31. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  32. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  33. PATHOBIOLOGY OF COLORECTAL CANCER
    Glenn Steele; Fiscal Year: 1991
    ....
  34. PATHOBIOLOGY OF COLORECTAL CANCER
    Glenn Steele; Fiscal Year: 1990
    ..Clinical progress in this disease will depend upon the kind of meshing of basic biologists and clinical researchers that this program project represents...
  35. EST. INVESTIGATOR CAREER AWARD IN PREVENTION, CONTROL BEHAVIORAL & POPULATION RES
    Noel Weiss; Fiscal Year: 2006
    ..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
  36. EST. INVESTIGATOR CAREER AWARD IN PREVENTION, CONTROL BEHAVIORAL & POPULATION RES
    Noel Weiss; Fiscal Year: 2005
    ..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
  37. TITLE OMITTED
    Noel Weiss; Fiscal Year: 2003
    ..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
  38. TITLE OMITTED
    Noel Weiss; Fiscal Year: 2002
    ..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
  39. EST. INVESTIGATOR CAREER AWARD IN PREVENTION, CONTROL BEHAVIORAL & POPULATION RES
    Noel Weiss; Fiscal Year: 2004
    ..Based on past experience, these faculty will be located both within and outside the University of Washington. ..
  40. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2008
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  41. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2003
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  42. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2005
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  43. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  44. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2004
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  45. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2007
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  46. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2001
    ..abstract_text> ..
  47. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2000
    ..abstract_text> ..
  48. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 1999
    ..abstract_text> ..
  49. Use of Geographic Variations to Estimate Effectiveness with Non-Randomized Data
    Mary Beth Landrum; Fiscal Year: 2010
    ..In addition, the methods developed will be applicable to a broad range of interventions for cancer and other diseases, providing a framework for future comparative effectiveness studies and ultimately changes in treatment guidelines. ..
  50. Radiation-induced signaling and treatment resistance
    BERT O NEIL; Fiscal Year: 2008
    ..The long-term goal of our research is to apply drugs that target tumor but not normal tissue in addition to radiation to improve the effectiveness of radiation on rectal cancer. ..
  51. Radiation-induced signaling and treatment resistance
    BERT O NEIL; Fiscal Year: 2007
    ..The long-term goal of our research is to apply drugs that target tumor but not normal tissue in addition to radiation to improve the effectiveness of radiation on rectal cancer. ..
  52. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2006
    ..Statistical analyses include RM-ANOVA, generalized estimation equation methodology and multiple regression analysis. Results may inform development of clinical guidelines for fatigue management during adjuvant CT. ..
  53. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2008
    ..The results will introduce novel, more accurate diagnostic tests and also identify new therapeutic targets to improve the outcome of this often devastating disease. ..
  54. Enhancing Colorectal Cancer Screening in Primary Care
    Electra D Paskett; Fiscal Year: 2010
    ..If successful, this program can easily be adapted for use by primary care practices and clinics to improve CRC screening. ..
  55. Evaluation of Biliary Strictures by IDUS, DIA, and FISH
    Michael Levy; Fiscal Year: 2005
    ..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
  56. THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMA
    Nancy Kemeny; Fiscal Year: 1999
    ..Cryosurgery and newer hepatic arterial therapies are therapeutic modalities that can be used in patients in whom liver resection is impossible. ..
  57. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2010
    ..The results will introduce novel, more accurate diagnostic tests and also identify new therapeutic targets to improve the outcome of this often devastating disease. ..
  58. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2004
    ..Further, the findings will help to better understand the effect of early brain lesion on reorganizational processes in the developing brain. ..
  59. International Conference on Malignant Bowel Obstruction
    Robert Krouse; Fiscal Year: 2004
    ..Using MBO as a model, a consensus will be attained for methodological approaches and the implementation of palliative care research. ..
  60. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2004
    ..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. ..
  61. Replication Study of Breast Cancer Susceptibility Genes in Blacks
    Dezheng Huo; Fiscal Year: 2009
    ..This study will advance understanding the genetic risk factors for breast cancer in women of African descent and will be invaluable in developing novel prevention strategies in the future. ..
  62. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2006
    ..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. [unreadable] [unreadable] [unreadable]..
  63. Integrative Genetic Epidemiologic Study of Breast Cancer Subtypes
    Dezheng Huo; Fiscal Year: 2008
    ..We will interrogate these complementary data to pinpoint the genetic determinants of breast cancer development and progression, and, in turn, provide new knowledge for its prevention and treatment. ..
  64. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2005
    ..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. ..
  65. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2005
    ..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. ..
  66. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2006
    ..The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings. [unreadable] [unreadable] [unreadable]..
  67. HR-QOL in Colorectal Cancer Survivors with Stomas
    Robert Krouse; Fiscal Year: 2009
    ....