Genomes and Genes
Summary: Functional, metabolic, or structural changes, including necrosis, in ischemic tissues thought to result from REPERFUSION to ischemic areas of the tissue. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Publications327 found, 100 shown here
- Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial functionJohn W Elrod
Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 104:15560-5. 2007....
- TLR4 activation mediates kidney ischemia/reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
J Clin Invest 117:2847-59. 2007Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
- Exosome secreted by MSC reduces myocardial ischemia/reperfusion injuryRuenn Chai Lai
Institute of Medical Biology, ASTAR, 138648 Singapore
Stem Cell Res 4:214-22. 2010..MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles...
- IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injuryLi Li
Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 120:331-42. 2010..We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-..
- Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a reviewNiteen Tapuria
Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
J Surg Res 150:304-30. 2008..a critical period of ischemia results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury. Ischemia reperfusion injury is often seen in organ transplants, major organ resections and in shock...
- Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injuryJaya Mishra
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Am Soc Nephrol 14:2534-43. 2003..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
- Identification of a microRNA signature of renal ischemia reperfusion injuryJonathan G Godwin
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:14339-44. 2010Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined expression profiles of miRNAs following renal IRI...
- Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathwayYajing Yuan
Department of Anesthesiology, Xiangya Hospital of Central South University, Hunan 410008, China
Brain Res 1367:85-93. 2011..These results suggest that Postcond protects brain from I/R injury by suppressing ER stress-induced apoptosis and PI3K/Akt pathway is involved...
- Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reactionYen Ta Chen
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
J Transl Med 9:51. 2011..We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury...
- Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injuryWilhelm J Schwaeble
Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
Proc Natl Acad Sci U S A 108:7523-8. 2011..lectin-associated serine protease-2 (MASP-2), and analyzed the role of MASP-2 in two models of postischemic reperfusion injury (IRI)...
- Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioningHartmut Jaeschke
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Am J Physiol Gastrointest Liver Physiol 284:G15-26. 2003Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation...
- Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injuryFlorian Tögel
Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
Am J Physiol Renal Physiol 292:F1626-35. 2007..that mesenchymal stem cells (MSC), unlike fibroblasts, are significantly renoprotective after ischemia-reperfusion injury and concluded that this renoprotection is mediated primarily by paracrine mechanisms...
- Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injuryKiyoshi Mori
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 115:610-21. 2005..Using a mouse model of severe renal failure, ischemia-reperfusion injury, we show that a single dose of Ngal (10 microg), introduced during the initial phase of the disease, ..
- Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stressLele Ji
Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
Am J Physiol Endocrinol Metab 298:E871-80. 2010..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
- Macrophages, dendritic cells, and kidney ischemia-reperfusion injuryLi Li
Department of Medicine and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
Semin Nephrol 30:268-77. 2010..early initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury. They are the most abundant leukocytes present in the kidney, and they represent a heterogeneous population ..
- Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequencyFei Zhou
Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
J Appl Physiol (1985) 111:1877-87. 2011..Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA...
- The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusionAllan Tsung
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Exp Med 201:1135-43. 2005..Together, these results demonstrate that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process...
- Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylationFeng Gao
Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Circulation 105:1497-502. 2002....
- Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injuryP J Crack
Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
J Neurochem 78:1389-99. 2001..Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to the extreme oxidative stress that is released during ischemia/reperfusion injury.
- The local and systemic inflammatory transcriptome after acute kidney injuryDmitry N Grigoryev
Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
J Am Soc Nephrol 19:547-58. 2008..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
- Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathwaysRobert F Schwabe
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006..In light of recent findings, pharmacological inhibitors of JNK and IKK and antioxidants may be promising new tools for the treatment of hepatitis, ischemia-reperfusion injury, and hepatocellular carcinoma.
- Transient limb ischemia induces remote ischemic preconditioning in vivoR K Kharbanda
University College, London, UK
Circulation 106:2881-3. 2002..We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size...
- Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injuryYong Gu
School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
J Neurochem 120:147-56. 2012..and the production of nitric oxide (NO) induced the loss of cav-1 in focal cerebral ischemia and reperfusion injury. The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix ..
- Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signalingChih Ching Yang
Department of Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
Transplantation 88:1251-60. 2009..We hypothesized that repetitive hypoxic preconditioning (RHP) may provide long-lasting protection than single preconditioning against ischemia/reperfusion injury in rat kidneys through hypoxia-induced factor (HIF)-1-dependent pathway.
- 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathwayYan Zhang
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
J Mol Cell Cardiol 49:576-86. 2010..that high concentrations of aldehydes are responsible for much of the damage elicited by cardiac ischemia-reperfusion injury, while sublethal concentrations of aldehydes stimulate stress resistance pathways, to achieve ..
- Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammationY Zhai
The Dumont UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Transplant 11:1563-9. 2011Ischemia and reperfusion injury (IRI) is a dynamic process that involves two distinctive yet interrelated phases of ischemic organ damage and inflammation-mediated reperfusion injury...
- An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injuryAlana A Shigeoka
Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 185:6277-85. 2010..To examine the role of the inflammasome in renal ischemia-reperfusion injury (IRI) we also tested its downstream targets caspase 1, IL-1β, and IL-18...
- Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1Bo Xu
Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
J Surg Res 166:e157-64. 2011Systemic inflammatory response following ischemia-reperfusion injury (IRI) to a specific organ may cause injuries in multiple remote organs...
- HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signalingQing wu Yang
Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
J Cereb Blood Flow Metab 31:593-605. 2011..These results suggest that HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling...
- Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injuryJulia Biermann
University Eye Hospital Freiburg, University Medical Center, Killianstrasse 5, 79106 Freiburg, Germany
Invest Ophthalmol Vis Sci 51:3784-91. 2010..Further studies are needed to evaluate whether CO posttreatment may represent a therapeutic option counteracting ischemic neuronal injury...
- Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failureWanja M Bernhardt
Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
J Am Soc Nephrol 17:1970-8. 2006..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
- Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injuryHartmut Jaeschke
Liver Research Institute, University of Arizona, College of Medicine, Room 6309, 1501 N Campbell Avenue, Tucson, Arizona, USA
Gastroenterology 125:1246-57. 2003..However, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.
- Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearmStavros P Loukogeorgakis
Vascular Physiology Unit, Institute of Child Health, University College London, London, WC1N 3JE, United Kingdom
Circulation 113:1015-9. 2006..The aim of this study was to determine whether postconditioning protects against endothelial IR injury in humans, in vivo...
- Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injurySuk Yee Li
Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
PLoS ONE 6:e16380. 2011..The present study suggests that LBP may have a neuroprotective role to play in ocular diseases for which I/R is a feature...
- Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liverMark R Duranski
Department of Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
J Clin Invest 115:1232-40. 2005..These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states...
- Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous systemStavros P Loukogeorgakis
Vascular Physiology Unit, Institute of Child Health, University College London, London, United Kingdom
J Am Coll Cardiol 46:450-6. 2005..The aim of this study was to characterize the time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in humans...
- Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidneyFangming Lin
Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
J Clin Invest 115:1756-64. 2005..Following ischemia/reperfusion injury (IRI), EGFP-positive cells showed incorporation of BrdU and expression of vimentin, which provides direct ..
- Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formationDeepu R Pillai
Department of Neurology, Regensburg University Medical Center, Regensburg, Germany
J Cereb Blood Flow Metab 29:1846-55. 2009..Stroke therapy aimed at vasogenic edema and drug delivery for neuroprotection may also be guided according to the functional status of the BBB, and these findings have to be confirmed in human stroke...
- Factors in the pathophysiology of the liver ischemia-reperfusion injuryEduardo E Montalvo-Jave
Department of Surgery, National Autonomous University of Mexico, Mexico City, Mexico
J Surg Res 147:153-9. 2008Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma...
- High-mobility group box-1 in ischemia-reperfusion injury of the heartMartin Andrassy
Department of Medicine III, University of Heidelberg, Heidelberg, Germany
Circulation 117:3216-26. 2008..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
- HMGB1 contributes to kidney ischemia reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
J Am Soc Nephrol 21:1878-90. 2010..TLR4 activation mediates kidney ischemia-reperfusion injury (IRI), but whether HMGB1 contributes to IRI is unknown...
- Toll-like receptors in ischemia-reperfusion injuryThiruma V Arumugam
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
Shock 32:4-16. 2009..A greater understanding of the role of TLRs in I/R injuries may aid in the development of specific TLR-targeted therapeutics to treat these conditions...
- Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allograftsChristopher D Anderson
Departments of Surgery, Washington University, St Louis, MO 63110, USA
Liver Transpl 17:189-200. 2011..These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft...
- Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptorKouki Fukuda
Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
Invest Ophthalmol Vis Sci 51:3629-38. 2010..an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II antagonist against retinal ischemia-reperfusion injury in the rat retina. METHODS. Retinal ischemia was induced by increasing intraocular pressure to 130 mm Hg...
- ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in ratsKátia D da Silveira
Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
Clin Sci (Lond) 119:385-94. 2010..In conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin-angiotensin system)-related peptidases support an important role for the ACE2-Ang-(1-7)-Mas axis in AKI...
- Hemeoxygenase-1 and renal ischaemia-reperfusion injuryDavid A Ferenbach
MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
Nephron Exp Nephrol 115:e33-7. 2010..efficacy of strategies to upregulate enzyme activity in ameliorating the severity of experimental ischaemia-reperfusion injury whilst genetic ablation of HO-1 or pharmacological inhibition of HO-1 activity results in an augmented ..
- Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in ratsYunwei Wei
Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
BMC Gastroenterol 10:42. 2010Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure...
- Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injuryM Lv
Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China
Neuroscience 176:162-72. 2011..TLR2 activation results in IL-23 production which stimulates IL-17 production by microglia. This microglial axis may be a potential therapeutic target to control neuroinflammation in brain IR...
- Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injuryMartin Schneider
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
Gastroenterology 138:1143-54.e1-2. 2010..We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and protect them against hepatic I/R damage...
- Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cellsSergey V Brodsky
Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8152, USA
Am J Physiol Renal Physiol 282:F1140-9. 2002..These observations strongly suggest that endothelial cell dysfunction is the primary cause of the no-reflow phenomenon, which, when ameliorated, results in prevention of renal injury seen in acute renal failure...
- Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophagesYuan Ji Day
Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
Am J Physiol Renal Physiol 288:F722-31. 2005The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A(2A)) receptors (A(2A)Rs) mediates tissue protection...
- Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injuryAparna Krishnamoorthy
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Blood 118:1934-42. 2011..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease...
- Postconditioning protects against human endothelial ischaemia-reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition poreMichael I Okorie
Centre for Clinical Pharmacology, University College London, The Rayne Institute, 5 University Street, London, UK
Eur Heart J 32:1266-74. 2011....
- Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat modelHiroyuki Kanazawa
Division of Development of Advanced Treatment, Center for Development of Advanced Medical Technology, Jichi Medical University, Yakushiji City, Tochigi, Japan
PLoS ONE 6:e19195. 2011..Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy...
- Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cellsVincenzo Cantaluppi
Dialysis and Kidney Transplantation Unit, Department of Internal Medicine, Center for Experimental Medical Research CeRMS and Nephrology, University of Torino, Torino, Italy
Kidney Int 82:412-27. 2012..Here, we tested whether these microvesicles prevent acute kidney injury in a rat model of ischemia-reperfusion injury. The RNA content of microvesicles was enriched in microRNAs (miRNAs) that modulate proliferation, ..
- Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxideMohamed Amine Zaouali
Experimental Hepatic Ischemia Reperfusion Unit, Institut of Biomedical Research of Barcelona, Spanish National Research Council, 08036, Barcelona, Spain
World J Gastroenterol 16:3499-509. 2010To examine the relevance of hypoxia inducible factor (HIF-1) and nitric oxide (NO) on the preservation of fatty liver against cold ischemia-reperfusion injury (IRI).
- Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injuryKolenkode B Kannan
Dept of Surgery, UMDNJ New Jersey Medical School, Newark, 07103, USA
Am J Physiol Gastrointest Liver Physiol 300:G853-61. 2011..However, the duration and severity of the gut I/R insult dictate whether HIF-1 plays a gut-protective or deleterious role...
- GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injuryRosanna Di Paola
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
J Leukoc Biol 88:291-301. 2010..Based on these findings, we propose that GW0742 would be useful in the treatment of various I/R diseases...
- Molecular mechanisms of liver preconditioningElisa Alchera
Department of Medical Sciences, University of East Piedmont A Avogadro, Via Solaroli 17, 28100 Novara, Italy
World J Gastroenterol 16:6058-67. 2010....
- The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injuryHongbao Liu
Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi an, China
PLoS ONE 7:e34608. 2012..These results advance our knowledge about SDF-1-CXCR4/CXCR7 axis as an attractive target pathway for improving the beneficial effects of MSC-based therapies for renal I/R...
- Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injuryQingqing Wei
Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
J Am Soc Nephrol 21:756-61. 2010..of microRNAs in the renal cortex; however, these animals were remarkably resistant to renal ischemia-reperfusion injury (IRI), showing significantly better renal function, less tissue damage, lower tubular apoptosis, and ..
- Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic ratsMassimo Collino
Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
Free Radic Biol Med 50:345-53. 2011..Thus, we report herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response...
- Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injuryHideaki Oharazawa
Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
Invest Ophthalmol Vis Sci 51:487-92. 2010..This study was conducted to explore the neuroprotective effect of H(2)-loaded eye drops on retinal I/R injury...
- Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury modelDaniel M Rosenbaum
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
J Neurosci Res 88:1569-76. 2010..Conclusion: Necroptosis is an important mode of neuronal cell death and involves autophagy in a model of retinal ischemia...
- Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signalingSaurabh Jha
Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
Am J Physiol Heart Circ Physiol 295:H801-6. 2008..These results indicate that H(2)S protects the murine liver against I/R injury through an upregulation of intracellular antioxidant and antiapoptotic signaling pathways...
- Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injuryRaghu Kempegowda Tadagavadi
Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Immunol 185:3750-8. 2010Overwhelming evidence suggests that ischemia-reperfusion injury of the kidney is an inflammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inflammatory responses...
- Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injuryAlvin K H Cheung
Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Exp Eye Res 85:608-16. 2007..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
- Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in ratsXingfeng Zheng
Chinese PLA Institute of Burn Surgery and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
Free Radic Res 43:478-84. 2009..In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress...
- Hydrogen sulfide and ischemia-reperfusion injuryChad K Nicholson
Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, United States
Pharmacol Res 62:289-97. 2010..This review will provide a detailed description of the role H(2)S plays in different model systems of I/R injury and will also detail some of the mechanisms involved with its cytoprotection...
- Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioningDiego C Fernandez
Departamento de Bioquimica Humana, Universidad de Buenos Aires, CEFYBO CONICET, Buenos Aires, Argentina
Invest Ophthalmol Vis Sci 50:3922-30. 2009..The authors investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage...
- Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanismsKang Lu
Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
J Neurochem 114:237-46. 2010..Future research should focus on the possible cross-talk between the MEK/ERK pathway and the NF-kappaB transcriptional cascade...
- Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injuryG Serviddio
Institute of Internal Medicine, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
Gut 57:957-65. 2008..Mitochondrial dysfunction represents a key factor in the progression of non-alcoholic steatohepatitis (NASH) as mitochondria are the main cellular site of fatty acid oxidation, ATP synthesis and reactive oxygen species (ROS) production...
- The interaction between ischemia-reperfusion and immune responses in the kidneyHye Ryoun Jang
Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Mol Med (Berl) 87:859-64. 2009Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses...
- Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injuryTakashi Shichita
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
Nat Med 15:946-50. 2009..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
- Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatmentK M Park
Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
J Biol Chem 276:11870-6. 2001..The post-ischemic activation patterns of MAPKs may explain the remarkable protection against ischemic injury observed in this model...
- Hepatic ischemia/reperfusion injury--a fresh lookConstantino Fondevila
Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Exp Mol Pathol 74:86-93. 2003..Finally, the activation of toll-like receptors on Kupffer cells may play a fundamental role in exploring new therapeutic strategies based on the concept that hepatic I/R injury represents a case for a host "innate" immunity...
- Laryngeal transplantation in 2005: a reviewM A Birchall
Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
Am J Transplant 6:20-6. 2006..This review seeks to outline the progress achieved in this field by 2005 and to point the way forward for laryngeal transplantation research in the 21st century...
- Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditionsHartmut Jaeschke
Liver Research Institute, College of Medicine, University of Arizona, Tucson, 85724, USA
Am J Physiol Gastrointest Liver Physiol 290:G1083-8. 2006..g., ischemia-reperfusion injury, in many organs including the liver...
- Directed migration of neuronal precursors into the ischemic cerebral cortex and striatumKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Mol Cell Neurosci 24:171-89. 2003..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
- Calcium, mitochondria and reperfusion injury: a pore way to dieA P Halestrap
Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Biochem Soc Trans 34:232-7. 2006..Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke...
- Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockadeR Russo
Department of Pharmacobiology, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Arcavacata di Rende, Italy
J Neurochem 107:1347-57. 2008..In addition, these data implicate the pro-survival PI3K/Akt pathway and the observed reduced expression of Bad in the neuroprotection afforded by MK801...
- Inflammation in acute kidney injuryGilbert R Kinsey
Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
Nephron Exp Nephrol 109:e102-7. 2008Ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI) and evidence supporting the involvement of both innate and adaptive immunity in renal IRI has accumulated in recent years...
- Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbilsS Gupta
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali Punjab
Indian J Physiol Pharmacol 51:62-8. 2007Involvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid ..
- Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in ratsGul Daglar
Department of Fourth Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey
J Surg Res 153:31-8. 2009Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections. Leukotrienes have been shown to play a major role in hepatic I/R injury...
- Renal hypoxia and dysoxia after reperfusion of the ischemic kidneyMatthieu Legrand
Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Mol Med 14:502-16. 2008..Their role in the development of ischemia-induced renal damage and ischemic acute renal failure are discussed...
- Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injuryYuan Zhai
Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont UCLA Transplant Center, Los Angeles, CA 90095, USA
Transplantation 85:1016-22. 2008..a key role in the induction of intrahepatic inflammation, leading to hepatocellular damage in liver ischemia/reperfusion injury (IRI), the nature of TLR4 ligands generated during tissue injury remains to be elucidated...
- The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcerYuki Saito
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
J Invest Dermatol 128:1838-51. 2008..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
- Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injuryMan Jiang
Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
Am J Pathol 176:1181-92. 2010..Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis...
- Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury modelNurdan Bedirli
Department of Anesthesiology, Diskapi Training and Research Hospital, Ankara, Turkey
Anesth Analg 106:830-7, table of contents. 2008..We investigated the effects of isoflurane and sevoflurane in a warm liver ischemia-reperfusion (IR) model on cytokines, hepatic tissue blood flow (HTBF), energy content, and liver structure...
- The impact of purinergic signaling on renal ischemia-reperfusion injuryBo Lu
Immunology Research Centre, St Vincent s Hospital, Melbourne, Victoria, Australia
Transplantation 86:1707-12. 2008Adenosine provides renovascular protection in mouse models of ischemia-reperfusion injury (I/RI) through purinergic members of the G protein-coupled receptor family, such as the adenosine 2A receptor (A2AR)...
- Mitochondrial mechanism of neuroprotection by CARTPeizhong Mao
Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
Eur J Neurosci 26:624-32. 2007..The findings suggest that CART's neuroprotective mechanism of action may be linked to preservation of mitochondrial function and prevention of energy failure after ischemia-reperfusion injury.
- Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia/reperfusion injury in ratsZafer Teke
Faculty of Medicine, Department of General Surgery, Pamukkale University, 20070 Denizli, Turkey
Am J Surg 194:255-62. 2007..In recent animal studies, destructive effects of reperfusion injury has been demonstrated...
- FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injuryJerome Cau
INSERM, U927, University Poitiers, Poitiers, France
J Vasc Surg 49:728-40. 2009..TNF-alpha) is a prominent proinflammatory factor implicated in the pathophysiology of acute renal ischemia reperfusion injury (IRI), we hypothesized that FR167653 (FR), a potent inhibitor of TNF-alpha and interleukin-1beta production, ..
- Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapiesJie Pan
Department of Radiology, Columbia University, 177 Fort Washington Ave, MHB 8SK, New York, NY 10032, USA
Neuroradiology 49:93-102. 2007..reperfusion may exacerbate the injury initially caused by ischemia, producing a so-called "cerebral reperfusion injury"...
- Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brainJ S Li
Department of Neurology, Changhai Hospital, 168 Changhai Road, Shanghai, PR China
Neuroscience 159:1309-15. 2009..pathway was involved in hyperbaric oxygen preconditioning (HBO-PC)-induced neuroprotection on ischemia-reperfusion injury in rat brain...
- Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activationDaqing Ma
Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, United Kingdom
J Am Soc Nephrol 20:713-20. 2009..In a model of renal ischemia-reperfusion injury, xenon provided morphologic and functional renoprotection; hydrodynamic injection of HIF-1alpha small ..
- An in vivo autotransplant model of renal preservation: cold storage versus machine perfusion in the prevention of ischemia/reperfusion injuryGaetano La Manna
Nephrology, Dialysis and Renal Transplant Unit, University of Bologna, St Orsola Hospital, Bologna, Italy
Artif Organs 33:565-70. 2009There is increasing proof that organ preservation by machine perfusion is able to limit ischemia/reperfusion injury in kidney transplantation...
- Early vulnerability to ischemia/reperfusion injury in motor terminals innervating fast muscles of SOD1-G93A miceGavriel David
Department of Physiology and Biophysics, University of Miami Miller School of Medicine, USA
Exp Neurol 204:411-20. 2007..Early vulnerability of fast motor terminals to I/R injury thus may signal, and possibly contribute to, early events involved in motor neuron death...
- Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in ratsHisato Tsuboi
Department of Inflammation and Immunology, Kyoto Prefectural Univ of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
Am J Physiol Gastrointest Liver Physiol 292:G678-83. 2007....
- Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds?M D Menger
Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
Transplant Proc 39:485-8. 2007..In recent experimental studies, these compounds have been shown to be effective to reduce post-ischemic-reperfusion injury, and, additionally, to be associated with less side effects...
- Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acidsAshraf Mohammad El-Badry
Swiss HPB Hepato Pancreatico Biliary Centre, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
Hepatology 45:855-63. 2007Macrovesicular hepatic steatosis has a lower tolerance to reperfusion injury than microvesicular steatosis with an abnormally high ratio of omega-6 (n-6): omega-3 (n-3) polyunsaturated fatty acids (PUFAs)...
- Myocardial Salvage With a Novel Reperfusion TherapyCONSTANCE WILSON; Fiscal Year: 2005..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may involve ..
- Redox Mechanisms of Ischemia Reperfusion Injury in the LiverJohn F Engelhardt; Fiscal Year: 2010Hepatic ischemia/reperfusion injury (I/R) is an important clinical problem associated with orthotopic liver transplantation, hepatic resection, and other surgical procedures that transiently alter hepatic blood flow...
- MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIAGREGORY STAHL; Fiscal Year: 2007While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
- Role of TLR-4 in Lung Reperfusion InjuryMICHAEL SCOTT MULLIGAN; Fiscal Year: 2010Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased recipient mortality...
- MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTIONGregory L Stahl; Fiscal Year: 2011DESCRIPTION (provided by applicant): While the exact mechanisms of ischemia/reperfusion injury remain unclear, our laboratory and others have shown that inhibition of complement activation (e.g...
- Molecular Structure and Regulation of the Permeability Transition PoreMichael A Forte; Fiscal Year: 2010..to play a key role in mitochondrial dysfunction associated with human pathological events such as ischemia-reperfusion injury and neurodegeneration...
- Rheologic and Vascular Modulators in Sickle Vaso-occlusionDhananjay Kaul; Fiscal Year: 2009..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
- Rheologic and Vascular Modulators in Sickle Vaso-occlusionDhananjay K Kaul; Fiscal Year: 2010..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
- Rheologic and Vascular Modulators in Sickle Vaso-occlusionDhananjay K Kaul; Fiscal Year: 2011..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
- Modulation of Mitochondrial Function by Pro-OxidantsLUKE IGNATIUS SZWEDA; Fiscal Year: 2010..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
- Clinical and genomic responses to remote ischemic preconditioningBrian McCrindle; Fiscal Year: 2007..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
- Modulation of Mitochondrial Function by Pro-OxidantsLuke Szweda; Fiscal Year: 2007..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
- Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia ReperfusionAh Lim Tsai; Fiscal Year: 2010..in the normal cardiac physiology and various cardiac pathological events including myocardial ischemia and reperfusion injury. Dynamic expression and activation of specific NOS isozyme occurs at different stages of the disease ..
- Oxidative Stress and Nitric Oxide in Aged MyocardiumROBERT LASLEY; Fiscal Year: 2005..However there have been limited studies of ischemia-reperfusion injury in in vivo aged myocardium and few systematic investigations of mitochondrial function in intact ventricular ..
- INFLAMMATORY AND THROMBOTIC CELL INTERACTIONS IN STROKELeslie Ritter; Fiscal Year: 2000..This is known as cerebral ischemia-reperfusion injury. The initial events in cerebral ischemia-reperfusion injury are complex and involve inflammatory (leukocytes)..
- Preoperative Therapy for Prevention of Postoperative Low Cardiac Output SyndromeD Benson; Fiscal Year: 2007..methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for infants undergoing cardiopulmonary bypass...
- MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVERJOHN ENGELHARDT; Fiscal Year: 2004..abstract_text> ..