reperfusion injury

Summary

Summary: Functional, metabolic, or structural changes, including necrosis, in ischemic tissues thought to result from REPERFUSION to ischemic areas of the tissue. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Top Publications

  1. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
  2. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
  3. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
  4. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
  5. ncbi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008
  6. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
  7. pmc Identification of a microRNA signature of renal ischemia reperfusion injury
    Jonathan G Godwin
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14339-44. 2010
  8. doi Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway
    Yajing Yuan
    Department of Anesthesiology, Xiangya Hospital of Central South University, Hunan 410008, China
    Brain Res 1367:85-93. 2011
  9. pmc Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
    Yen Ta Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 9:51. 2011
  10. pmc Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
    Wilhelm J Schwaeble
    Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:7523-8. 2011

Detail Information

Publications327 found, 100 shown here

  1. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
    ....
  2. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
  3. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
    ..MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles...
  4. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-..
  5. ncbi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008
    ..a critical period of ischemia results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury. Ischemia reperfusion injury is often seen in organ transplants, major organ resections and in shock...
  6. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  7. pmc Identification of a microRNA signature of renal ischemia reperfusion injury
    Jonathan G Godwin
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14339-44. 2010
    Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined expression profiles of miRNAs following renal IRI...
  8. doi Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway
    Yajing Yuan
    Department of Anesthesiology, Xiangya Hospital of Central South University, Hunan 410008, China
    Brain Res 1367:85-93. 2011
    ..These results suggest that Postcond protects brain from I/R injury by suppressing ER stress-induced apoptosis and PI3K/Akt pathway is involved...
  9. pmc Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
    Yen Ta Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 9:51. 2011
    ..We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury...
  10. pmc Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
    Wilhelm J Schwaeble
    Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:7523-8. 2011
    ..lectin-associated serine protease-2 (MASP-2), and analyzed the role of MASP-2 in two models of postischemic reperfusion injury (IRI)...
  11. ncbi Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Physiol Gastrointest Liver Physiol 284:G15-26. 2003
    Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation...
  12. ncbi Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury
    Florian Tögel
    Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Renal Physiol 292:F1626-35. 2007
    ..that mesenchymal stem cells (MSC), unlike fibroblasts, are significantly renoprotective after ischemia-reperfusion injury and concluded that this renoprotection is mediated primarily by paracrine mechanisms...
  13. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..Using a mouse model of severe renal failure, ischemia-reperfusion injury, we show that a single dose of Ngal (10 microg), introduced during the initial phase of the disease, ..
  14. doi Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    Lele Ji
    Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 298:E871-80. 2010
    ..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
  15. pmc Macrophages, dendritic cells, and kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Semin Nephrol 30:268-77. 2010
    ..early initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury. They are the most abundant leukocytes present in the kidney, and they represent a heterogeneous population ..
  16. pmc Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency
    Fei Zhou
    Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
    J Appl Physiol (1985) 111:1877-87. 2011
    ..Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA...
  17. pmc The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
    ..Together, these results demonstrate that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process...
  18. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    ....
  19. ncbi Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
    P J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    J Neurochem 78:1389-99. 2001
    ..Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to the extreme oxidative stress that is released during ischemia/reperfusion injury.
  20. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  21. ncbi Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways
    Robert F Schwabe
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006
    ..In light of recent findings, pharmacological inhibitors of JNK and IKK and antioxidants may be promising new tools for the treatment of hepatitis, ischemia-reperfusion injury, and hepatocellular carcinoma.
  22. ncbi Transient limb ischemia induces remote ischemic preconditioning in vivo
    R K Kharbanda
    University College, London, UK
    Circulation 106:2881-3. 2002
    ..We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size...
  23. doi Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury
    Yong Gu
    School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 120:147-56. 2012
    ..and the production of nitric oxide (NO) induced the loss of cav-1 in focal cerebral ischemia and reperfusion injury. The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix ..
  24. doi Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling
    Chih Ching Yang
    Department of Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Transplantation 88:1251-60. 2009
    ..We hypothesized that repetitive hypoxic preconditioning (RHP) may provide long-lasting protection than single preconditioning against ischemia/reperfusion injury in rat kidneys through hypoxia-induced factor (HIF)-1-dependent pathway.
  25. ncbi 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway
    Yan Zhang
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Mol Cell Cardiol 49:576-86. 2010
    ..that high concentrations of aldehydes are responsible for much of the damage elicited by cardiac ischemia-reperfusion injury, while sublethal concentrations of aldehydes stimulate stress resistance pathways, to achieve ..
  26. pmc Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation
    Y Zhai
    The Dumont UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Transplant 11:1563-9. 2011
    Ischemia and reperfusion injury (IRI) is a dynamic process that involves two distinctive yet interrelated phases of ischemic organ damage and inflammation-mediated reperfusion injury...
  27. pmc An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
    Alana A Shigeoka
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:6277-85. 2010
    ..To examine the role of the inflammasome in renal ischemia-reperfusion injury (IRI) we also tested its downstream targets caspase 1, IL-1β, and IL-18...
  28. doi Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1
    Bo Xu
    Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
    J Surg Res 166:e157-64. 2011
    Systemic inflammatory response following ischemia-reperfusion injury (IRI) to a specific organ may cause injuries in multiple remote organs...
  29. pmc HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 31:593-605. 2011
    ..These results suggest that HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling...
  30. doi Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury
    Julia Biermann
    University Eye Hospital Freiburg, University Medical Center, Killianstrasse 5, 79106 Freiburg, Germany
    Invest Ophthalmol Vis Sci 51:3784-91. 2010
    ..Further studies are needed to evaluate whether CO posttreatment may represent a therapeutic option counteracting ischemic neuronal injury...
  31. ncbi Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  32. ncbi Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
    Hartmut Jaeschke
    Liver Research Institute, University of Arizona, College of Medicine, Room 6309, 1501 N Campbell Avenue, Tucson, Arizona, USA
    Gastroenterology 125:1246-57. 2003
    ..However, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.
  33. ncbi Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm
    Stavros P Loukogeorgakis
    Vascular Physiology Unit, Institute of Child Health, University College London, London, WC1N 3JE, United Kingdom
    Circulation 113:1015-9. 2006
    ..The aim of this study was to determine whether postconditioning protects against endothelial IR injury in humans, in vivo...
  34. pmc Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury
    Suk Yee Li
    Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e16380. 2011
    ..The present study suggests that LBP may have a neuroprotective role to play in ocular diseases for which I/R is a feature...
  35. pmc Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    Mark R Duranski
    Department of Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    J Clin Invest 115:1232-40. 2005
    ..These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states...
  36. ncbi Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system
    Stavros P Loukogeorgakis
    Vascular Physiology Unit, Institute of Child Health, University College London, London, United Kingdom
    J Am Coll Cardiol 46:450-6. 2005
    ..The aim of this study was to characterize the time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in humans...
  37. pmc Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
    Fangming Lin
    Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
    J Clin Invest 115:1756-64. 2005
    ..Following ischemia/reperfusion injury (IRI), EGFP-positive cells showed incorporation of BrdU and expression of vimentin, which provides direct ..
  38. pmc Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation
    Deepu R Pillai
    Department of Neurology, Regensburg University Medical Center, Regensburg, Germany
    J Cereb Blood Flow Metab 29:1846-55. 2009
    ..Stroke therapy aimed at vasogenic edema and drug delivery for neuroprotection may also be guided according to the functional status of the BBB, and these findings have to be confirmed in human stroke...
  39. pmc Factors in the pathophysiology of the liver ischemia-reperfusion injury
    Eduardo E Montalvo-Jave
    Department of Surgery, National Autonomous University of Mexico, Mexico City, Mexico
    J Surg Res 147:153-9. 2008
    Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma...
  40. ncbi High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    ..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
  41. pmc HMGB1 contributes to kidney ischemia reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
    J Am Soc Nephrol 21:1878-90. 2010
    ..TLR4 activation mediates kidney ischemia-reperfusion injury (IRI), but whether HMGB1 contributes to IRI is unknown...
  42. doi Toll-like receptors in ischemia-reperfusion injury
    Thiruma V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Shock 32:4-16. 2009
    ..A greater understanding of the role of TLRs in I/R injuries may aid in the development of specific TLR-targeted therapeutics to treat these conditions...
  43. pmc Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts
    Christopher D Anderson
    Departments of Surgery, Washington University, St Louis, MO 63110, USA
    Liver Transpl 17:189-200. 2011
    ..These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft...
  44. doi Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
    Kouki Fukuda
    Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 51:3629-38. 2010
    ..an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II antagonist against retinal ischemia-reperfusion injury in the rat retina. METHODS. Retinal ischemia was induced by increasing intraocular pressure to 130 mm Hg...
  45. ncbi ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats
    Kátia D da Silveira
    Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Clin Sci (Lond) 119:385-94. 2010
    ..In conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin-angiotensin system)-related peptidases support an important role for the ACE2-Ang-(1-7)-Mas axis in AKI...
  46. doi Hemeoxygenase-1 and renal ischaemia-reperfusion injury
    David A Ferenbach
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    Nephron Exp Nephrol 115:e33-7. 2010
    ..efficacy of strategies to upregulate enzyme activity in ameliorating the severity of experimental ischaemia-reperfusion injury whilst genetic ablation of HO-1 or pharmacological inhibition of HO-1 activity results in an augmented ..
  47. pmc Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    Yunwei Wei
    Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
    BMC Gastroenterol 10:42. 2010
    Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure...
  48. doi Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury
    M Lv
    Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China
    Neuroscience 176:162-72. 2011
    ..TLR2 activation results in IL-23 production which stimulates IL-17 production by microglia. This microglial axis may be a potential therapeutic target to control neuroinflammation in brain IR...
  49. doi Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury
    Martin Schneider
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    Gastroenterology 138:1143-54.e1-2. 2010
    ..We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and protect them against hepatic I/R damage...
  50. ncbi Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells
    Sergey V Brodsky
    Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8152, USA
    Am J Physiol Renal Physiol 282:F1140-9. 2002
    ..These observations strongly suggest that endothelial cell dysfunction is the primary cause of the no-reflow phenomenon, which, when ameliorated, results in prevention of renal injury seen in acute renal failure...
  51. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A(2A)) receptors (A(2A)Rs) mediates tissue protection...
  52. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011
    ..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease...
  53. doi Postconditioning protects against human endothelial ischaemia-reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition pore
    Michael I Okorie
    Centre for Clinical Pharmacology, University College London, The Rayne Institute, 5 University Street, London, UK
    Eur Heart J 32:1266-74. 2011
    ....
  54. pmc Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model
    Hiroyuki Kanazawa
    Division of Development of Advanced Treatment, Center for Development of Advanced Medical Technology, Jichi Medical University, Yakushiji City, Tochigi, Japan
    PLoS ONE 6:e19195. 2011
    ..Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy...
  55. doi Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells
    Vincenzo Cantaluppi
    Dialysis and Kidney Transplantation Unit, Department of Internal Medicine, Center for Experimental Medical Research CeRMS and Nephrology, University of Torino, Torino, Italy
    Kidney Int 82:412-27. 2012
    ..Here, we tested whether these microvesicles prevent acute kidney injury in a rat model of ischemia-reperfusion injury. The RNA content of microvesicles was enriched in microRNAs (miRNAs) that modulate proliferation, ..
  56. pmc Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxide
    Mohamed Amine Zaouali
    Experimental Hepatic Ischemia Reperfusion Unit, Institut of Biomedical Research of Barcelona, Spanish National Research Council, 08036, Barcelona, Spain
    World J Gastroenterol 16:3499-509. 2010
    To examine the relevance of hypoxia inducible factor (HIF-1) and nitric oxide (NO) on the preservation of fatty liver against cold ischemia-reperfusion injury (IRI).
  57. pmc Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury
    Kolenkode B Kannan
    Dept of Surgery, UMDNJ New Jersey Medical School, Newark, 07103, USA
    Am J Physiol Gastrointest Liver Physiol 300:G853-61. 2011
    ..However, the duration and severity of the gut I/R insult dictate whether HIF-1 plays a gut-protective or deleterious role...
  58. doi GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury
    Rosanna Di Paola
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Leukoc Biol 88:291-301. 2010
    ..Based on these findings, we propose that GW0742 would be useful in the treatment of various I/R diseases...
  59. pmc Molecular mechanisms of liver preconditioning
    Elisa Alchera
    Department of Medical Sciences, University of East Piedmont A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    World J Gastroenterol 16:6058-67. 2010
    ....
  60. pmc The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury
    Hongbao Liu
    Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e34608. 2012
    ..These results advance our knowledge about SDF-1-CXCR4/CXCR7 axis as an attractive target pathway for improving the beneficial effects of MSC-based therapies for renal I/R...
  61. pmc Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury
    Qingqing Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
    J Am Soc Nephrol 21:756-61. 2010
    ..of microRNAs in the renal cortex; however, these animals were remarkably resistant to renal ischemia-reperfusion injury (IRI), showing significantly better renal function, less tissue damage, lower tubular apoptosis, and ..
  62. doi Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
    ..Thus, we report herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response...
  63. doi Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
    Hideaki Oharazawa
    Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 51:487-92. 2010
    ..This study was conducted to explore the neuroprotective effect of H(2)-loaded eye drops on retinal I/R injury...
  64. ncbi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia...
  65. pmc Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling
    Saurabh Jha
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Physiol Heart Circ Physiol 295:H801-6. 2008
    ..These results indicate that H(2)S protects the murine liver against I/R injury through an upregulation of intracellular antioxidant and antiapoptotic signaling pathways...
  66. ncbi Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
    Overwhelming evidence suggests that ischemia-reperfusion injury of the kidney is an inflammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inflammatory responses...
  67. ncbi Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
    Alvin K H Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Exp Eye Res 85:608-16. 2007
    ..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
  68. doi Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats
    Xingfeng Zheng
    Chinese PLA Institute of Burn Surgery and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Free Radic Res 43:478-84. 2009
    ..In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress...
  69. pmc Hydrogen sulfide and ischemia-reperfusion injury
    Chad K Nicholson
    Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, United States
    Pharmacol Res 62:289-97. 2010
    ..This review will provide a detailed description of the role H(2)S plays in different model systems of I/R injury and will also detail some of the mechanisms involved with its cytoprotection...
  70. ncbi Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioning
    Diego C Fernandez
    Departamento de Bioquimica Humana, Universidad de Buenos Aires, CEFYBO CONICET, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 50:3922-30. 2009
    ..The authors investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage...
  71. doi Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    Kang Lu
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
    J Neurochem 114:237-46. 2010
    ..Future research should focus on the possible cross-talk between the MEK/ERK pathway and the NF-kappaB transcriptional cascade...
  72. ncbi Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
    G Serviddio
    Institute of Internal Medicine, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Gut 57:957-65. 2008
    ..Mitochondrial dysfunction represents a key factor in the progression of non-alcoholic steatohepatitis (NASH) as mitochondria are the main cellular site of fatty acid oxidation, ATP synthesis and reactive oxygen species (ROS) production...
  73. doi The interaction between ischemia-reperfusion and immune responses in the kidney
    Hye Ryoun Jang
    Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Mol Med (Berl) 87:859-64. 2009
    Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses...
  74. doi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  75. ncbi Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment
    K M Park
    Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
    J Biol Chem 276:11870-6. 2001
    ..The post-ischemic activation patterns of MAPKs may explain the remarkable protection against ischemic injury observed in this model...
  76. ncbi Hepatic ischemia/reperfusion injury--a fresh look
    Constantino Fondevila
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:86-93. 2003
    ..Finally, the activation of toll-like receptors on Kupffer cells may play a fundamental role in exploring new therapeutic strategies based on the concept that hepatic I/R injury represents a case for a host "innate" immunity...
  77. ncbi Laryngeal transplantation in 2005: a review
    M A Birchall
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Am J Transplant 6:20-6. 2006
    ..This review seeks to outline the progress achieved in this field by 2005 and to point the way forward for laryngeal transplantation research in the 21st century...
  78. ncbi Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
    Hartmut Jaeschke
    Liver Research Institute, College of Medicine, University of Arizona, Tucson, 85724, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1083-8. 2006
    ..g., ischemia-reperfusion injury, in many organs including the liver...
  79. ncbi Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Cell Neurosci 24:171-89. 2003
    ..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
  80. ncbi Calcium, mitochondria and reperfusion injury: a pore way to die
    A P Halestrap
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochem Soc Trans 34:232-7. 2006
    ..Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke...
  81. doi Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade
    R Russo
    Department of Pharmacobiology, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Arcavacata di Rende, Italy
    J Neurochem 107:1347-57. 2008
    ..In addition, these data implicate the pro-survival PI3K/Akt pathway and the observed reduced expression of Bad in the neuroprotection afforded by MK801...
  82. pmc Inflammation in acute kidney injury
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Nephron Exp Nephrol 109:e102-7. 2008
    Ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI) and evidence supporting the involvement of both innate and adaptive immunity in renal IRI has accumulated in recent years...
  83. ncbi Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils
    S Gupta
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali Punjab
    Indian J Physiol Pharmacol 51:62-8. 2007
    Involvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid ..
  84. doi Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in rats
    Gul Daglar
    Department of Fourth Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey
    J Surg Res 153:31-8. 2009
    Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections. Leukotrienes have been shown to play a major role in hepatic I/R injury...
  85. pmc Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
    Matthieu Legrand
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 14:502-16. 2008
    ..Their role in the development of ischemia-induced renal damage and ischemic acute renal failure are discussed...
  86. doi Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury
    Yuan Zhai
    Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont UCLA Transplant Center, Los Angeles, CA 90095, USA
    Transplantation 85:1016-22. 2008
    ..a key role in the induction of intrahepatic inflammation, leading to hepatocellular damage in liver ischemia/reperfusion injury (IRI), the nature of TLR4 ligands generated during tissue injury remains to be elucidated...
  87. ncbi The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
    ..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
  88. pmc Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    Man Jiang
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Pathol 176:1181-92. 2010
    ..Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis...
  89. ncbi Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury model
    Nurdan Bedirli
    Department of Anesthesiology, Diskapi Training and Research Hospital, Ankara, Turkey
    Anesth Analg 106:830-7, table of contents. 2008
    ..We investigated the effects of isoflurane and sevoflurane in a warm liver ischemia-reperfusion (IR) model on cytokines, hepatic tissue blood flow (HTBF), energy content, and liver structure...
  90. doi The impact of purinergic signaling on renal ischemia-reperfusion injury
    Bo Lu
    Immunology Research Centre, St Vincent s Hospital, Melbourne, Victoria, Australia
    Transplantation 86:1707-12. 2008
    Adenosine provides renovascular protection in mouse models of ischemia-reperfusion injury (I/RI) through purinergic members of the G protein-coupled receptor family, such as the adenosine 2A receptor (A2AR)...
  91. pmc Mitochondrial mechanism of neuroprotection by CART
    Peizhong Mao
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Eur J Neurosci 26:624-32. 2007
    ..The findings suggest that CART's neuroprotective mechanism of action may be linked to preservation of mitochondrial function and prevention of energy failure after ischemia-reperfusion injury.
  92. ncbi Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia/reperfusion injury in rats
    Zafer Teke
    Faculty of Medicine, Department of General Surgery, Pamukkale University, 20070 Denizli, Turkey
    Am J Surg 194:255-62. 2007
    ..In recent animal studies, destructive effects of reperfusion injury has been demonstrated...
  93. doi FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injury
    Jerome Cau
    INSERM, U927, University Poitiers, Poitiers, France
    J Vasc Surg 49:728-40. 2009
    ..TNF-alpha) is a prominent proinflammatory factor implicated in the pathophysiology of acute renal ischemia reperfusion injury (IRI), we hypothesized that FR167653 (FR), a potent inhibitor of TNF-alpha and interleukin-1beta production, ..
  94. pmc Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies
    Jie Pan
    Department of Radiology, Columbia University, 177 Fort Washington Ave, MHB 8SK, New York, NY 10032, USA
    Neuroradiology 49:93-102. 2007
    ..reperfusion may exacerbate the injury initially caused by ischemia, producing a so-called "cerebral reperfusion injury"...
  95. doi Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain
    J S Li
    Department of Neurology, Changhai Hospital, 168 Changhai Road, Shanghai, PR China
    Neuroscience 159:1309-15. 2009
    ..pathway was involved in hyperbaric oxygen preconditioning (HBO-PC)-induced neuroprotection on ischemia-reperfusion injury in rat brain...
  96. pmc Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, United Kingdom
    J Am Soc Nephrol 20:713-20. 2009
    ..In a model of renal ischemia-reperfusion injury, xenon provided morphologic and functional renoprotection; hydrodynamic injection of HIF-1alpha small ..
  97. ncbi An in vivo autotransplant model of renal preservation: cold storage versus machine perfusion in the prevention of ischemia/reperfusion injury
    Gaetano La Manna
    Nephrology, Dialysis and Renal Transplant Unit, University of Bologna, St Orsola Hospital, Bologna, Italy
    Artif Organs 33:565-70. 2009
    There is increasing proof that organ preservation by machine perfusion is able to limit ischemia/reperfusion injury in kidney transplantation...
  98. pmc Early vulnerability to ischemia/reperfusion injury in motor terminals innervating fast muscles of SOD1-G93A mice
    Gavriel David
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, USA
    Exp Neurol 204:411-20. 2007
    ..Early vulnerability of fast motor terminals to I/R injury thus may signal, and possibly contribute to, early events involved in motor neuron death...
  99. ncbi Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in rats
    Hisato Tsuboi
    Department of Inflammation and Immunology, Kyoto Prefectural Univ of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G678-83. 2007
    ....
  100. ncbi Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds?
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Transplant Proc 39:485-8. 2007
    ..In recent experimental studies, these compounds have been shown to be effective to reduce post-ischemic-reperfusion injury, and, additionally, to be associated with less side effects...
  101. ncbi Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids
    Ashraf Mohammad El-Badry
    Swiss HPB Hepato Pancreatico Biliary Centre, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
    Hepatology 45:855-63. 2007
    Macrovesicular hepatic steatosis has a lower tolerance to reperfusion injury than microvesicular steatosis with an abnormally high ratio of omega-6 (n-6): omega-3 (n-3) polyunsaturated fatty acids (PUFAs)...

Research Grants89

  1. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may involve ..
  2. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2010
    Hepatic ischemia/reperfusion injury (I/R) is an important clinical problem associated with orthotopic liver transplantation, hepatic resection, and other surgical procedures that transiently alter hepatic blood flow...
  3. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS DELL ITALIA; Fiscal Year: 2009
    ..Myocardial ischemia/reperfusion injury occurs in a wide spectrum of patients, ranging from survivors of out- of-hospital cardiac arrest to AMI ..
  4. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..And 4) increases the reparative function of human diabetic CD34 EPC in SCID mice following ischemia/ reperfusion injury. Overall Hypothesis: Transient blockade of endogenous transforming growth factor-beta type 1 (TGF-b1) using ..
  5. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    Thomas Ebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Abstract Title of grant: Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Ischemia-reperfusion (I/R) injury to vital organs and tissue can occur in a variety of clinical ..
  6. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..S1P was sufficient to decrease infarction and enhance contractility in mouse hearts subjected to ischemia-reperfusion injury. We also developed a rapid and accurate radioassay for measurement of sphingosine kinase activity and ..
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2009
    ..will test our hypothesis that the IL4/13/STAT6/PC1 pathway is activated in a mouse model of renal ischemia/reperfusion injury. In Aim 2, we will test whether crossing of STAT6 null mice with polycystic mouse models will result in ..
  8. Mechanims of complement induced myocardial ischemia
    GREGORY STAHL; Fiscal Year: 2006
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  9. Mechanims of complement induced myocardial ischemia
    GREGORY STAHL; Fiscal Year: 2005
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  10. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  11. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2003
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  12. Mechanims of complement induced myocardial ischemia
    GREGORY STAHL; Fiscal Year: 2004
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  13. Role of TLR-4 in Lung Reperfusion Injury
    Michael Mulligan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis ..
  14. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis ..
  15. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting Zhao; Fiscal Year: 2009
    ..Myocardial ischemia/reperfusion injury is still a major unsolved problem...
  16. New methods to deliver therapeutic drugs in myocardial ischemia/reperfusion injur
    Richard Vander Heide; Fiscal Year: 2010
    ..MI results from ischemia/reperfusion injury (IR)...
  17. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2009
    ..apoptosis contributes to adverse ventricular remodeling after myocardial infarction and myocardial ischemia-reperfusion injury. We have developed microsurgical procedures to generate myocardial infarction and ischemia-reperfusion ..
  18. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    Gregory L Stahl; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): While the exact mechanisms of ischemia/reperfusion injury remain unclear, our laboratory and others have shown that inhibition of complement activation (e.g...
  19. Tissue factor in smooth and cardiac muscle
    MARK TAUBMAN; Fiscal Year: 2001
    ..A number of recent reports have shown that TF inhibitors reduce ischemia/reperfusion injury. The mechanism underlying this reduction has not been determined...
  20. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John Buolamwini; Fiscal Year: 2009
    ..5 billion per year. Ischemia-reperfusion injury is the major cause of complications of cardiac surgery;morbidity and mortality, but current cardioprotective ..
  21. Tissue factor in smooth and cardiac muscle
    MARK TAUBMAN; Fiscal Year: 2004
    ..A number of recent reports have shown that TF inhibitors reduce ischemia/reperfusion injury. The mechanism underlying this reduction has not been determined...
  22. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicant's abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium...
  23. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium...
  24. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium...
  25. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Ischemia-reperfusion injury (IRI) is a major problem in many clinical scenarios, including myocardial infarction and stroke...
  26. The Role of Complement in Hepatic Ischemia Reperfusion Injury and Regeneration
    KEELY MORRIS; Fiscal Year: 2010
    ..Ischemia and reperfusion injury (IRI) is unavoidable in the vast majority of liver resections performed...
  27. ROLE OF ADENOSINE IN MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1990
    ..anatomic events occur with reperfusion which may limit the amount of potentially salvageable myocardium ("REPERFUSION INJURY")...
  28. Innate Immunity, Biomarkers and Myocardial Infarction
    GREGORY STAHL; Fiscal Year: 2009
    ..While the exact mechanisms of ischemia/reperfusion injury remain unclear, inhibition of complement activation (e.g...
  29. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..While the exact mechanisms of ischemia/reperfusion injury remain unclear, inhibition of complement activation (e.g...
  30. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..5 billion per year. Ischemia-reperfusion injury is the major cause of complications of cardiac surgery;morbidity and mortality, but current cardioprotective ..
  31. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  32. Prevention of ischemia reperfusion injury associated with acute myocardial infarc
    Craig Sherman; Fiscal Year: 2010
    ..and owns patent rights to a recently discovered use for sodium nitrite as a means to prevent ischemia-reperfusion injury. Ischemia-reperfusion injury refers to tissue damage caused when blood supply returns to the tissue after a ..
  33. PRESERVATION OF THE ISCHEMIC/REPERFUSED MYOCARDIUM
    Michael Hess; Fiscal Year: 1990
    ..generation of cytotoxic oxygen free radicals occupies an important role in the pathophysiology of ischemic/reperfusion injury. Our previous work has developed the working hypothesis that myocardial ischemia results in the ..
  34. Molecular Structure and Regulation of the Permeability Transition Pore
    Michael Forte; Fiscal Year: 2009
    ..to play a key role in mitochondrial dysfunction associated with human pathological events such as ischemia-reperfusion injury and neurodegeneration...
  35. Molecular Structure and Regulation of the Permeability Transition Pore
    Michael A Forte; Fiscal Year: 2010
    ..to play a key role in mitochondrial dysfunction associated with human pathological events such as ischemia-reperfusion injury and neurodegeneration...
  36. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    GREGORY STAHL; Fiscal Year: 2009
    While the exact mechanisms of ischemia/reperfusion injury remain unclear, our laboratory and others have shown that inhibition of complement activation (e.g., sCR1 or C1 esterase inhibitor), depletion of complement components (e.g...
  37. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..hypertension, or kidneys subjected to prolonged cold ischemia and exhibiting increased ischemia-normothermic reperfusion injury and delayed graft function, therefore necessitating dialysis in the recipient...
  38. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2009
    ..hypertension, or kidneys subjected to prolonged cold ischemia and exhibiting increased ischemia-normothermic reperfusion injury and delayed graft function, therefore necessitating dialysis in the recipient...
  39. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1990
    ..events and/or anatomic changes occur with reperfusion that may limit the amount of salvageable myocardium ("reperfusion injury")...
  40. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2009
    ....
  41. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay Kaul; Fiscal Year: 2009
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  42. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2010
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  43. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2011
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  44. REGULATION OF E-SELECTIN DURING ACUTE INFLAMMATION
    Kevin Billups; Fiscal Year: 1999
    ..In addition to acute infectious etiologies, it is becoming increasingly clear that ischemia/reperfusion injury triggers a striking acute inflammatory response that contributes to tissue damage and organ failure...
  45. ISCHEMIA-REPERFUSION INJURY AFTER LUNG TRANSPLANTATION
    Joel Cooper; Fiscal Year: 1990
    ..of lung transplantation, the so-called "reimplantation response", is in fact a manifestation of ischemia-reperfusion injury to the transplanted lung...
  46. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2010
    ..renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline ..
  47. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    JOHN ENGELHARDT; Fiscal Year: 2009
    Hepatic ischemia/reperfusion injury (I/R) is an important clinical problem associated with orthotopic liver transplantation, hepatic resection, and other surgical procedures that transiently alter hepatic blood flow...
  48. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith Webster; Fiscal Year: 2009
    ..Experiments are proposed to test this hypothesis in mouse models. If our hypothesis is correct we will described the molecular basis for this an begin to develop new approaches for treatment. ..
  49. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  50. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  51. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ischemia-reperfusion injury (IRI) occurs in organs when circulation is interrupted, causing ischemia, and then ischemic tissue is reperfused...
  52. Clinical and genomic responses to remote ischemic preconditioning
    Brian McCrindle; Fiscal Year: 2009
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  53. Clinical and genomic responses to remote ischemic preconditioning
    Brian McCrindle; Fiscal Year: 2007
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  54. Modulation of Mitochondrial Function by Pro-Oxidants
    Luke Szweda; Fiscal Year: 2007
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  55. Modulation of Mitochondrial Function by Pro-Oxidants
    Luke Szweda; Fiscal Year: 2009
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  56. Clinical and genomic responses to remote ischemic preconditioning
    Brian McCrindle; Fiscal Year: 2006
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  57. CELLULAR OXIDATIVE TARGETS IN CARDIAC REPERFUSION INJURY
    Anirban Banerjee; Fiscal Year: 1990
    ..b) Minimizing adverse effects with 'tailored' reperfusion, and finally c) Repairing the effects of reperfusion injury. We propose to assess a mechanism of myocardial reperfusion injury involving the oxidation of thiol groups ..
  58. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..A key goal of preconditioning is to reduce the damage inflicted by ischemia-reperfusion injury (IRI) that occurs when the ischemic/ hypoxic organ is connected to the recipient's circulation...
  59. Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2010
    ..in the normal cardiac physiology and various cardiac pathological events including myocardial ischemia and reperfusion injury. Dynamic expression and activation of specific NOS isozyme occurs at different stages of the disease ..
  60. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2004
    ..However there have been limited studies of ischemia-reperfusion injury in in vivo aged myocardium and few systematic investigations of mitochondrial function in intact ventricular ..
  61. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..However there have been limited studies of ischemia-reperfusion injury in in vivo aged myocardium and few systematic investigations of mitochondrial function in intact ventricular ..
  62. INFLAMMATORY AND THROMBOTIC CELL INTERACTIONS IN STROKE
    Leslie Ritter; Fiscal Year: 2000
    ..This is known as cerebral ischemia-reperfusion injury. The initial events in cerebral ischemia-reperfusion injury are complex and involve inflammatory (leukocytes)..
  63. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Benson; Fiscal Year: 2006
    ..methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for infants undergoing cardiopulmonary bypass...
  64. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Benson; Fiscal Year: 2007
    ..methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for infants undergoing cardiopulmonary bypass...
  65. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Benson; Fiscal Year: 2009
    ..methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for infants undergoing cardiopulmonary bypass...
  66. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 1999
    ..inhibition of this pathway can help define the mechanisms regulating CD62P and its role in PMN-mediated reperfusion injury, potentially leading to modulation of PMN-mediated injury...
  67. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..inhibition of this pathway can help define the mechanisms regulating CD62P and its role in PMN-mediated reperfusion injury, potentially leading to modulation of PMN-mediated injury...
  68. Redox Regulation of the rho-GTPases in the vasculature
    Sharon Campbell; Fiscal Year: 2009
    ..has been shown to contribute to lung diseases such as acute respiratory distress syndrome and ischemia-reperfusion injury. Thus, information derived from this effort may aid in developing therapies to combat vascular pathologies ..
  69. MICROCIRCULATORY STUDIES OF REPERFUSION INJURY
    Mark Keller; Fiscal Year: 1990
    b>Reperfusion injury is an important clinical disorder which may become manifest during blood reperfusion of ischemic tissues...
  70. MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVER
    JOHN ENGELHARDT; Fiscal Year: 2004
    ..abstract_text> ..
  71. MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVER
    JOHN ENGELHARDT; Fiscal Year: 2003
    ..abstract_text> ..
  72. MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVER
    JOHN ENGELHARDT; Fiscal Year: 2002
    ..abstract_text> ..
  73. MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVER
    JOHN ENGELHARDT; Fiscal Year: 2000
    ..abstract_text> ..