reperfusion injury

Summary

Summary: Functional, metabolic, or structural changes, including necrosis, in ischemic tissues thought to result from REPERFUSION to ischemic areas of the tissue. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Top Publications

  1. ncbi Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
  2. ncbi Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
    Hideaki Oharazawa
    Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 51:487-92. 2010
  3. ncbi Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling
    Saurabh Jha
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Physiol Heart Circ Physiol 295:H801-6. 2008
  4. ncbi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
  5. ncbi Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    Kang Lu
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
    J Neurochem 114:237-46. 2010
  6. ncbi Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    Lele Ji
    Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 298:E871-80. 2010
  7. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
  8. ncbi Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats
    Xingfeng Zheng
    Chinese PLA Institute of Burn Surgery and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Free Radic Res 43:478-84. 2009
  9. ncbi Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioning
    Diego C Fernandez
    Departamento de Bioquimica Humana, Universidad de Buenos Aires, CEFYBO CONICET, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 50:3922-30. 2009
  10. ncbi Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
    Alvin K H Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Exp Eye Res 85:608-16. 2007

Research Grants

  1. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
  2. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
  3. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2010
  4. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    Gregory L Stahl; Fiscal Year: 2011
  5. Molecular Structure and Regulation of the Permeability Transition Pore
    Michael A Forte; Fiscal Year: 2010
  6. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2010
  7. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay Kaul; Fiscal Year: 2009
  8. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2011
  9. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2010
  10. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010

Detail Information

Publications275 found, 100 shown here

  1. ncbi Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
    ....
  2. ncbi Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
    Hideaki Oharazawa
    Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 51:487-92. 2010
    ..This study was conducted to explore the neuroprotective effect of H(2)-loaded eye drops on retinal I/R injury...
  3. ncbi Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling
    Saurabh Jha
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Physiol Heart Circ Physiol 295:H801-6. 2008
    ..These results indicate that H(2)S protects the murine liver against I/R injury through an upregulation of intracellular antioxidant and antiapoptotic signaling pathways...
  4. ncbi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Conclusion: Necroptosis is an important mode of neuronal cell death and involves autophagy in a model of retinal ischemia...
  5. ncbi Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    Kang Lu
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
    J Neurochem 114:237-46. 2010
    ..Future research should focus on the possible cross-talk between the MEK/ERK pathway and the NF-kappaB transcriptional cascade...
  6. ncbi Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    Lele Ji
    Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 298:E871-80. 2010
    ..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
  7. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
    ..MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles...
  8. ncbi Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats
    Xingfeng Zheng
    Chinese PLA Institute of Burn Surgery and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Free Radic Res 43:478-84. 2009
    ..In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress...
  9. ncbi Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioning
    Diego C Fernandez
    Departamento de Bioquimica Humana, Universidad de Buenos Aires, CEFYBO CONICET, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 50:3922-30. 2009
    ..The authors investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage...
  10. ncbi Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
    Alvin K H Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Exp Eye Res 85:608-16. 2007
    ..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
  11. ncbi Hydrogen sulfide and ischemia-reperfusion injury
    Chad K Nicholson
    Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, United States
    Pharmacol Res 62:289-97. 2010
    ..This review will provide a detailed description of the role H(2)S plays in different model systems of I/R injury and will also detail some of the mechanisms involved with its cytoprotection...
  12. ncbi Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
    Overwhelming evidence suggests that ischemia-reperfusion injury of the kidney is an inflammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inflammatory responses...
  13. ncbi Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
    G Serviddio
    Institute of Internal Medicine, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Gut 57:957-65. 2008
    ..Mitochondrial dysfunction represents a key factor in the progression of non-alcoholic steatohepatitis (NASH) as mitochondria are the main cellular site of fatty acid oxidation, ATP synthesis and reactive oxygen species (ROS) production...
  14. ncbi Laryngeal transplantation in 2005: a review
    M A Birchall
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Am J Transplant 6:20-6. 2006
    ..This review seeks to outline the progress achieved in this field by 2005 and to point the way forward for laryngeal transplantation research in the 21st century...
  15. ncbi IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-..
  16. ncbi Hepatic ischemia/reperfusion injury--a fresh look
    Constantino Fondevila
    Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:86-93. 2003
    ..Finally, the activation of toll-like receptors on Kupffer cells may play a fundamental role in exploring new therapeutic strategies based on the concept that hepatic I/R injury represents a case for a host "innate" immunity...
  17. ncbi Transient limb ischemia induces remote ischemic preconditioning in vivo
    R K Kharbanda
    University College, London, UK
    Circulation 106:2881-3. 2002
    ..We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size...
  18. ncbi The interaction between ischemia-reperfusion and immune responses in the kidney
    Hye Ryoun Jang
    Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Mol Med (Berl) 87:859-64. 2009
    Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses...
  19. ncbi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  20. ncbi Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment
    K M Park
    Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA
    J Biol Chem 276:11870-6. 2001
    ..The post-ischemic activation patterns of MAPKs may explain the remarkable protection against ischemic injury observed in this model...
  21. ncbi Calcium, mitochondria and reperfusion injury: a pore way to die
    A P Halestrap
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochem Soc Trans 34:232-7. 2006
    ..Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke...
  22. ncbi Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Cell Neurosci 24:171-89. 2003
    ..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
  23. ncbi Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
    Hartmut Jaeschke
    Liver Research Institute, College of Medicine, University of Arizona, Tucson, 85724, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1083-8. 2006
    ..g., ischemia-reperfusion injury, in many organs including the liver...
  24. ncbi Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury
    Florian Tögel
    Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Renal Physiol 292:F1626-35. 2007
    ..that mesenchymal stem cells (MSC), unlike fibroblasts, are significantly renoprotective after ischemia-reperfusion injury and concluded that this renoprotection is mediated primarily by paracrine mechanisms...
  25. ncbi Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury model
    Nurdan Bedirli
    Department of Anesthesiology, Diskapi Training and Research Hospital, Ankara, Turkey
    Anesth Analg 106:830-7, table of contents. 2008
    ..We investigated the effects of isoflurane and sevoflurane in a warm liver ischemia-reperfusion (IR) model on cytokines, hepatic tissue blood flow (HTBF), energy content, and liver structure...
  26. ncbi Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies
    Jie Pan
    Department of Radiology, Columbia University, 177 Fort Washington Ave, MHB 8SK, New York, NY 10032, USA
    Neuroradiology 49:93-102. 2007
    ..reperfusion may exacerbate the injury initially caused by ischemia, producing a so-called "cerebral reperfusion injury"...
  27. ncbi Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury
    Yuan Zhai
    Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont UCLA Transplant Center, Los Angeles, CA 90095, USA
    Transplantation 85:1016-22. 2008
    ..a key role in the induction of intrahepatic inflammation, leading to hepatocellular damage in liver ischemia/reperfusion injury (IRI), the nature of TLR4 ligands generated during tissue injury remains to be elucidated...
  28. ncbi Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
    Matthieu Legrand
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 14:502-16. 2008
    ..Their role in the development of ischemia-induced renal damage and ischemic acute renal failure are discussed...
  29. ncbi The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
    ..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
  30. ncbi Early vulnerability to ischemia/reperfusion injury in motor terminals innervating fast muscles of SOD1-G93A mice
    Gavriel David
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, USA
    Exp Neurol 204:411-20. 2007
    ..Early vulnerability of fast motor terminals to I/R injury thus may signal, and possibly contribute to, early events involved in motor neuron death...
  31. ncbi Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils
    S Gupta
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali Punjab
    Indian J Physiol Pharmacol 51:62-8. 2007
    Involvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid ..
  32. ncbi Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds?
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Transplant Proc 39:485-8. 2007
    ..In recent experimental studies, these compounds have been shown to be effective to reduce post-ischemic-reperfusion injury, and, additionally, to be associated with less side effects...
  33. ncbi Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids
    Ashraf Mohammad El Badry
    Swiss HPB Hepato Pancreatico Biliary Centre, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
    Hepatology 45:855-63. 2007
    Macrovesicular hepatic steatosis has a lower tolerance to reperfusion injury than microvesicular steatosis with an abnormally high ratio of omega-6 (n-6): omega-3 (n-3) polyunsaturated fatty acids (PUFAs)...
  34. ncbi Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen
    J A Buras
    Department of Biology and Department of Pharmaceutical Sciences, New England Inflammation and Tissue Protection Institute at Northeastern University, Boston, MA 02115, USA
    Neurol Res 29:127-31. 2007
    Ischemia/reperfusion injury plays a central role in the development of tissue injury during multiple central nervous system diseases including acute stroke...
  35. ncbi FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers
    Kwan Man
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Am J Transplant 5:40-9. 2005
    Hepatic ischemia-reperfusion injury is an inevitable consequence during liver surgery. The outcome is particularly poor in cirrhotic livers, which are more prone to hepatic ischemia-reperfusion injury...
  36. ncbi Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia/reperfusion injury in rats
    Zafer Teke
    Faculty of Medicine, Department of General Surgery, Pamukkale University, 20070 Denizli, Turkey
    Am J Surg 194:255-62. 2007
    ..In recent animal studies, destructive effects of reperfusion injury has been demonstrated...
  37. ncbi Mitochondrial mechanism of neuroprotection by CART
    Peizhong Mao
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Eur J Neurosci 26:624-32. 2007
    ..The findings suggest that CART's neuroprotective mechanism of action may be linked to preservation of mitochondrial function and prevention of energy failure after ischemia-reperfusion injury.
  38. ncbi Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice
    Ashish K Rehni
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India
    Behav Brain Res 183:95-100. 2007
    ..has been designed to investigate the effect of amniotic fluid derived stem cells on focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice...
  39. ncbi Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in rats
    Hisato Tsuboi
    Department of Inflammation and Immunology, Kyoto Prefectural Univ of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G678-83. 2007
    ....
  40. ncbi Inflammation in acute kidney injury
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Nephron Exp Nephrol 109:e102-7. 2008
    Ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI) and evidence supporting the involvement of both innate and adaptive immunity in renal IRI has accumulated in recent years...
  41. ncbi Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain
    J S Li
    Department of Neurology, Changhai Hospital, 168 Changhai Road, Shanghai, PR China
    Neuroscience 159:1309-15. 2009
    ..pathway was involved in hyperbaric oxygen preconditioning (HBO-PC)-induced neuroprotection on ischemia-reperfusion injury in rat brain...
  42. ncbi FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injury
    Jerome Cau
    INSERM, U927, University Poitiers, Poitiers, France
    J Vasc Surg 49:728-40. 2009
    ..TNF-alpha) is a prominent proinflammatory factor implicated in the pathophysiology of acute renal ischemia reperfusion injury (IRI), we hypothesized that FR167653 (FR), a potent inhibitor of TNF-alpha and interleukin-1beta production, ..
  43. ncbi An in vivo autotransplant model of renal preservation: cold storage versus machine perfusion in the prevention of ischemia/reperfusion injury
    Gaetano La Manna
    Nephrology, Dialysis and Renal Transplant Unit, University of Bologna, St Orsola Hospital, Bologna, Italy
    Artif Organs 33:565-70. 2009
    There is increasing proof that organ preservation by machine perfusion is able to limit ischemia/reperfusion injury in kidney transplantation...
  44. ncbi Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants
    Wenwu Zhou
    Department of Cardiothoracic Surgery, Hunan Children s Hospital, Changsha, Hunan, China
    Pediatr Cardiol 31:22-9. 2010
    Open heart surgery supported by cardiopulmonary bypass is associated with heart and lung ischemia-reperfusion injury (IRI)...
  45. ncbi Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    Man Jiang
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Pathol 176:1181-92. 2010
    ..Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis...
  46. ncbi The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats
    Nou Ying Tang
    China Medical University, Taichung, Taiwan
    Am J Chin Med 38:51-64. 2010
    ..Paeoniflorin reduced cerebral infarct, at least in part, involves the anti-inflammatory properties...
  47. ncbi Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 78:1240-51. 2010
    ..We found that ischemia-reperfusion injury (IRI) in rodents reduced Klotho in the kidneys, urine, and blood, all of which were restored upon recovery...
  48. ncbi Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs
    J Yoshida
    Department of Surgery, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, USA
    Am J Transplant 10:763-72. 2010
    ..CO in UW provides significant protection against renal I/R injury in the porcine KTx model. Ex vivo exposure of kidney grafts to CO during cold storage may therefore be a safe strategy to reduce I/R injury...
  49. ncbi Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: the role of heme oxygenase-1
    Shaohua Song
    Organ Transplantation Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People s Republic of China
    Int Immunopharmacol 10:679-84. 2010
    ..Thus, SIN deserves further exploration as a novel agent to attenuate I/R injury...
  50. ncbi Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury
    Qingqing Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
    J Am Soc Nephrol 21:756-61. 2010
    ..of microRNAs in the renal cortex; however, these animals were remarkably resistant to renal ischemia-reperfusion injury (IRI), showing significantly better renal function, less tissue damage, lower tubular apoptosis, and ..
  51. ncbi HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 31:593-605. 2011
    ..These results suggest that HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling...
  52. ncbi Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model
    Hiroyuki Kanazawa
    Division of Development of Advanced Treatment, Center for Development of Advanced Medical Technology, Jichi Medical University, Yakushiji City, Tochigi, Japan
    PLoS ONE 6:e19195. 2011
    ..Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy...
  53. ncbi Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, United Kingdom
    J Am Soc Nephrol 20:713-20. 2009
    ..In a model of renal ischemia-reperfusion injury, xenon provided morphologic and functional renoprotection; hydrodynamic injection of HIF-1alpha small ..
  54. ncbi Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy
    Raphael Thuillier
    Inserm U927, Ischémie Reperfusion en Transplantation Rénale Université de Poitiers Faculté de Medecine et de Pharmacie, Poitiers, France
    Transplantation 90:612-21. 2010
    Ischemia-reperfusion injury (IRI) is an unavoidable component of transplantation and correlates with delayed graft function, acute rejection, chronic fibrosis, and graft loss...
  55. ncbi HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury
    Rena Feinman
    UMDNJ New Jersey Medical School, Dept of Surgery, Newark, 07103, USA
    Am J Physiol Gastrointest Liver Physiol 299:G833-43. 2010
    ..Consequently, these results provide unique information on the initiating events in trauma-hemorrhagic shock-induced ALI and MODS as well as potential therapeutic insights...
  56. ncbi Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats
    Xiao Ling Zhu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Neurosci Lett 449:24-7. 2009
    ..the therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury. Middle cerebral artery occlusion was conducted in male Sprague-Dawley rats and 20mg/kg tetramethylpyrazine ..
  57. ncbi Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in rats
    Gul Daglar
    Department of Fourth Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey
    J Surg Res 153:31-8. 2009
    Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections. Leukotrienes have been shown to play a major role in hepatic I/R injury...
  58. ncbi Cyanine dyes attenuate cerebral ischemia and reperfusion injury in rats
    Satomi Koya-Miyata
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc
    Biol Pharm Bull 33:1872-7. 2010
    ..These results suggest that NK-4 and NK-150 effectively prevented ischemia-induced brain injury through their potent neurotrophin-like activity as well as antioxidative activity...
  59. ncbi Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade
    R Russo
    Department of Pharmacobiology, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Arcavacata di Rende, Italy
    J Neurochem 107:1347-57. 2008
    ..In addition, these data implicate the pro-survival PI3K/Akt pathway and the observed reduced expression of Bad in the neuroprotection afforded by MK801...
  60. ncbi p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury
    Timothy A Sutton
    Div of Nephrology, Dept of Medicine, Indiana Univ School of Medicine, 950 West Walnut St, R II, 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 295:F1666-77. 2008
    Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and is characterized by widespread tubular and microvascular damage...
  61. ncbi The impact of purinergic signaling on renal ischemia-reperfusion injury
    Bo Lu
    Immunology Research Centre, St Vincent s Hospital, Melbourne, Victoria, Australia
    Transplantation 86:1707-12. 2008
    Adenosine provides renovascular protection in mouse models of ischemia-reperfusion injury (I/RI) through purinergic members of the G protein-coupled receptor family, such as the adenosine 2A receptor (A2AR)...
  62. ncbi Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats
    Tomohiro Kawamura
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1344-51. 2010
    ..The purpose of this research was to investigate whether inhaled hydrogen gas could reduce graft I/R injury during lung transplantation...
  63. ncbi S-Nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties
    Yu Ishima
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Exp Ther 320:969-77. 2007
    ....
  64. ncbi Protective effects of alpha-tocopherol and ischemic preconditioning on hepatic reperfusion injury
    Woo-Yong Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, Korea
    Arch Pharm Res 28:1392-9. 2005
    ..These results suggest that either alpha-TC or IPC reduces the level of mitochondrial damage associated with oxidative stress caused by hepatic I/R, but alpha-TC combined with IPC offers no significant additional protection...
  65. ncbi Evaluation of liver damage after application of TVE in the rat model
    G Darilmaz
    First Department of Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey
    Transplant Proc 37:4550-2. 2005
    ..The levels of malondialdehyde and myeloperoxidase were not altered significantly. CONCLUSION: Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion...
  66. ncbi Protective effect of EDTA preadministration on renal ischemia
    Chiara Foglieni
    Cardiovascular Department, Istituto Scientifico San Raffaele, Via Olgettina, 60 Milan, Italy
    BMC Nephrol 7:5. 2006
    ..This study was performed to identify the underlying mechanism of the ability of EDTA treatment to protect kidneys from damage...
  67. ncbi Effects of ischemic preconditioning on cyclinD1 expression during early ischemic reperfusion in rats
    Fang Gang Cai
    Department of General Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350004, Fujian Province, China
    World J Gastroenterol 12:2936-40. 2006
    ..To observe the effect of ischemic preconditioning on cyclinD1 expression in rat liver cells during early ischemic reperfusion...
  68. ncbi Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1
    I Rue Lai
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Transplantation 81:1311-7. 2006
    ..We have reported the protective role of heme oxygenase-1 (HO-1) in the mechanism of hypoxic preconditioning. We wish to investigate the role of HO-1 in remote preconditioning (RP) against hepatic ischemia/reperfusion (I/R) injury in rats...
  69. ncbi The effects of desferrioxamine and quercetin on hepatic ischemia-reperfusion induced renal disturbance
    Coskun Polat
    Department of General Surgery, Afyon Kocatepe University School of Medicine, Lal Apt No 7 24, 03200 Afyon, Turkey
    Prostaglandins Leukot Essent Fatty Acids 74:379-83. 2006
    ..The aim of this study was to analyze the effects of 45min of hepatic ischemia and 1h of reperfusion on renal oxidative stress parameters, on renal tissue damage, and the role of Desferrioxamin (Dfx) and Q on these parameters...
  70. ncbi Effect of steroid on mitochondrial oxidative stress enzymes, intestinal microflora, and bacterial translocation in rats subjected to temporary liver inflow occlusion
    V Kirimlioglu
    Department of General Surgery, Inonu University Turgut Ozal Medical Center, School of Medicine, Malatya, Turkey
    Transplant Proc 38:378-81. 2006
    ..Statistically significant increases in the intestinal counts of Klebsiella spp and Proteus spp and of bacterial translocation to liver, kidney, spleen, and MLN were measured in group B with respect to group A...
  71. ncbi Does anti-oxidant prophylaxis with melatonin prevent adverse outcomes related to increased oxidative stress caused by laparoscopy in experimental rat model?
    Ali Cay
    Department of Pediatric Surgery, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
    J Surg Res 135:2-8. 2006
    ....
  72. ncbi Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion of rat liver
    Yuji Takamatsu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dig Dis Sci 51:571-9. 2006
    ..These data show that generation of peroxynitrite could be involved in the pathogenesis of liver injury but not lung injury after hepatic I/R. Inhibition of iNOS could be applied for attenuation of liver injury following hepatic I/R...
  73. ncbi Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion
    Kang Hun Cho
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Arch Pharm Res 30:50-7. 2007
    ..In conclusion, chronic ethanol consumption was found to potentiate hepatocellular damage as indicated by abnormalities in microsomal drug metabolizing function during I/R...
  74. ncbi Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus
    Ersin Fadillioglu
    Faculty of Medicine, Department of Physiology, Hacettepe University, Ankara, 06100, Turkey
    Arch Pharm Res 31:705-12. 2008
    ..Also, it was concluded that melatonin treatment may prevent liver oxidant stress induced by distant injury of kidney IR...
  75. ncbi Protective effects of total flavones of rhododendra on cerebral ischemia reperfusion injury
    Yan Guo
    Department of Pharmacology, Anhui Medical University, Hefei, China, 230032, China
    Am J Chin Med 36:343-54. 2008
    ..protective effects and possible mechanisms of total flavones of rhododendra (TFR) against cerebral ischemia reperfusion injury in rats and mice...
  76. ncbi Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat
    Bianzhi Xing
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hang Kong Road 13, Wuhan, 430030, China
    Stroke 39:2362-9. 2008
    ..However, little is known about the mechanisms of Postcond in cerebral I/R injury. In the present study, we investigated the effects of Postcond in focal cerebral I/R injury in the rat middle cerebral artery occlusion model...
  77. ncbi Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats
    Jiasi Li
    Department of Neurology, Changhai Hospital, 174 Changhai Road, Shanghai 200433, PR China
    Brain Res 1210:223-9. 2008
    ..These observations demonstrated that an upregulation of the antioxidant enzyme activity by HBO preconditioning plays an important role in the generation of tolerance against brain ischemia-reperfusion injury.
  78. ncbi Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
    ..The present data indicate that infiltrating immune cells mediate or participate in the development of sodium-sensitive hypertension and renal damage in rats apparently recovered from renal I/R injury...
  79. ncbi Remote preconditioning reduces microcirculatory disorders in pancreatic ischemia/reperfusion injury
    Christina Oehmann
    Department of Surgery, University Hospital, Albert Ludwig University of Freiburg, Freiburg, Germany
    Pancreas 35:e45-50. 2007
    Remote preconditioning (RPC) can protect from ischemia/reperfusion injury (IRI). We investigated the influence of RPC in pancreatic IRI.
  80. ncbi [Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats]
    Hao Lu
    Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Zhonghua Yi Xue Za Zhi 87:2468-71. 2007
    To investigate the protective effect of pretreatment with Kupffer cell mediated emulsified isoflurane on ischemia/reperfusion injury in liver.
  81. ncbi Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion
    Olga S León Fernández
    Center for Research and Biological Evaluation CIEB IFAL, University of Havana, Havana, Cuba
    Transpl Int 21:39-48. 2008
    ..NO produced by OzoneOP may play a role in the pathways of cellular signalling which promote preservation of the cellular redox balance, mitochondrial function, glutathione pools as well as the regulation of NF-kappaB and HSP-70...
  82. ncbi Protective effects of melatonin and N-acetylcysteine on hepatic injury in a rat cardiopulmonary bypass model
    Hairong Huang
    Department of Cardiothoracic Surgery, Jinling Hospital, Clinical Medicine School of Nanjing University, Nanjing, China
    J Surg Res 142:153-61. 2007
    ..This study was designed to test the hypothesis that melatonin and N-acetylcysteine (NAC) could attenuate hepatic injury induced by CPB in rats...
  83. ncbi The hepatoprotective effect of carnosine against ischemia/reperfusion liver injury in rats
    Amr A Fouad
    Department of Pharmacology, Faculty of Medicine, Minia University, El Minia, Egypt
    Eur J Pharmacol 572:61-8. 2007
    ..These results strongly emphasize that carnosine can be useful as a prophylactic treatment to protect the liver against hypoxia-reoxygenation damage...
  84. ncbi Protective effects of combined ischemic preconditioning and ascorbic acid on mitochondrial injury in hepatic ischemia/reperfusion
    Woo Yong Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    J Surg Res 142:45-52. 2007
    ..This study examined the in vivo effects of ischemic preconditioning (IPC), ascorbic acid (AA), or a combination (IPC + AA) on the level of mitochondrial injury caused by hepatic ischemia/reperfusion (I/R)...
  85. ncbi Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats
    Atsuko Motoki
    Department of Anaesthesiology and Resuscitology, Ehime University Graduate School of Medicine, Shitsukawa, Touon shi, Ehime, Japan
    Basic Clin Pharmacol Toxicol 102:394-8. 2008
    Inflammatory reactions play an important role in ischaemia/reperfusion injury in various organs...
  86. ncbi Ischemic preconditioning and intermittent ischemia preserve bile flow in a rat model of ischemia reperfusion injury
    Vincent B Nieuwenhuijs
    The HPB and Liver Transplant Unit, Flinders Medical Centre and School of Medicine, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia
    Dig Dis Sci 52:1159-67. 2007
    ..It is concluded that IPC and INT substantially alleviate the decrease in bile flow induced by ischemia. Bile flow may be useful in the assessment of IR injury...
  87. ncbi The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex
    Oguz Aslan Ozen
    Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey
    Neurol Sci 29:147-52. 2008
    ..The activities of CAT increased in Group C as compared to Group B rats. The number of apoptotic neurons in the prefrontal cortex was lower in Group C as compared to Group B rats...
  88. ncbi Protective mechanism of L-arginine against liver ischemic-reperfusion injury in rats
    Shao Qiang Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Hepatobiliary Pancreat Dis Int 2:549-52. 2003
    ..To investigate the protective effect of L-arginine (L-arg) against liver ischemic-reperfusion (I/R) injury in rat model and its possible mechanism...
  89. ncbi Effect of leptin on renal ischemia-reperfusion damage in rats
    S Erkasap
    Department of General Surgery, Osmangazi University, Medical Faculty, Eskisehir, Turkey
    J Physiol Biochem 60:79-84. 2004
    ..These results suggest that leptin could exert a protective effect on I/R induced renal damage by decreasing TNF-alpha levels and increasing nitrite level...
  90. ncbi Protective effects of clopidogrel on oxidant damage in a rat model of acute ischemia
    Muhip Kanko
    Department of Cardiovascular Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey
    Tohoku J Exp Med 205:133-9. 2005
    b>Reperfusion injury is a consequence of inadequate energy supply and acidosis in ischemic tissues and a chain of events triggered by oxygen-derived free radicals released in response to exposure of oxygen...
  91. ncbi Tumor necrosis factor suppression and microcirculatory disturbance amelioration in ischemia/reperfusion injury of rat liver after ischemic preconditioning
    Masahiro Shinoda
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 17:1211-9. 2002
    ..Brief periods of hepatic ischemia produce immediate tolerance for subsequent prolonged ischemia. Although the beneficial effect of this ischemic preconditioning is recognized, the mechanism itself remains poorly understood...
  92. ncbi Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia
    Lucio Glantz
    Department of Anesthesiology, Rabin Medical Center, Beilinson Campus, Israel
    Exp Neurol 192:117-24. 2005
    ..Moreover, part of the neuroprotection afforded by IPC is mediated by the brain's ability to mobilize antioxidants, especially uric acid, that attenuate the massive ROS-mediated oxidative stress...
  93. ncbi Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver
    Moto Fukai
    First Department of Surgery, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan
    Free Radic Biol Med 38:1372-81. 2005
    ..Secondary LPO products are less sensitive, especially during ischemia, which may cause possible underestimation and discrepancy...
  94. ncbi Preconditioning effects on expression of proto-oncogenes c-fos and c-jun after hepatic ischemia/reperfusion in rats
    Jian Sheng Xiao
    Research Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hepatobiliary Pancreat Dis Int 4:197-202. 2005
    ..The purpose of this research was to investigate the effects of preconditioning on expression of immediate early genes c-fos and c-jun following hepatic ischemia/reperfusion (IR) and its roles in cellular regeneration and apoptosis...
  95. ncbi Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase
    Ferdinand Serracino-Inglott
    Division of Surgery, Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK
    BMC Gastroenterol 2:22. 2002
    ..Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated...
  96. ncbi Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury
    Hui-Chun Xing
    Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 4:274-80. 2005
    BACKGROUND: Hepatic ischemia/reperfusion injury may induce intestinal microflora imbalance. Salvia miltiorrhiza is effective in promoting blood circulation and counteracting peroxidation in tissues...
  97. ncbi Modulation of mitochondrial calcium management attenuates hepatic warm ischemia-reperfusion injury
    Christopher D Anderson
    Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN 37232 4753, USA
    Liver Transpl 11:663-8. 2005
    ..Hepatic IR injury resulted in both apoptotic and necrotic cell death, which were attenuated by RR pretreatment. In conclusion, these observations implicate mitochondrial calcium uptake in the pathogenesis of hepatic IR injury...
  98. ncbi Stimulation of p38 MAPK by hormonal preconditioning with atrial natriuretic peptide
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Butenandtstr 5 13, 81377 Munich, Germany
    World J Gastroenterol 8:707-11. 2002
    Stress-activated signaling pathways responsible for hepatic ischemia reperfusion injury and their modulation by protective interventions are widely unknown...
  99. ncbi Protective effect of ischemic preconditioning on liver
    Y Zhang
    Vascular Surgery, Affiliated Renji Hospital, Shanghai Second Medical University, Shanghai, 200001, China
    Chin J Traumatol 4:123-5. 2001
    OBJECTIVE: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury. METHODS: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made...
  100. ncbi Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon
    A Mehta
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cell Biochem 240:19-29. 2002
    ..an endothelin-1 converting enzyme inhibitor in ameliorating the MAPK induced damage during renal ischemia/reperfusion injury. Our previous results showed that 90 min of ischemia followed by reperfusion caused very severe injury and ..
  101. ncbi Can preconditioning reduce laparoscopy-induced tissue injury?
    S Yilmaz
    Department of General Surgery, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
    Surg Endosc 17:819-24. 2003
    ..In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I/R injury...

Research Grants88

  1. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may involve ..
  2. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  3. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2010
    Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased recipient mortality...
  4. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    Gregory L Stahl; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): While the exact mechanisms of ischemia/reperfusion injury remain unclear, our laboratory and others have shown that inhibition of complement activation (e.g...
  5. Molecular Structure and Regulation of the Permeability Transition Pore
    Michael A Forte; Fiscal Year: 2010
    ..to play a key role in mitochondrial dysfunction associated with human pathological events such as ischemia-reperfusion injury and neurodegeneration...
  6. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2010
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  7. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay Kaul; Fiscal Year: 2009
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  8. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2011
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  9. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2010
    Hepatic ischemia/reperfusion injury (I/R) is an important clinical problem associated with orthotopic liver transplantation, hepatic resection, and other surgical procedures that transiently alter hepatic blood flow...
  10. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  11. Modulation of Mitochondrial Function by Pro-Oxidants
    Luke Szweda; Fiscal Year: 2007
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  12. Clinical and genomic responses to remote ischemic preconditioning
    Brian McCrindle; Fiscal Year: 2007
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  13. Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2010
    ..in the normal cardiac physiology and various cardiac pathological events including myocardial ischemia and reperfusion injury. Dynamic expression and activation of specific NOS isozyme occurs at different stages of the disease ..
  14. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..However there have been limited studies of ischemia-reperfusion injury in in vivo aged myocardium and few systematic investigations of mitochondrial function in intact ventricular ..
  15. INFLAMMATORY AND THROMBOTIC CELL INTERACTIONS IN STROKE
    Leslie Ritter; Fiscal Year: 2000
    ..This is known as cerebral ischemia-reperfusion injury. The initial events in cerebral ischemia-reperfusion injury are complex and involve inflammatory (leukocytes)..
  16. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Benson; Fiscal Year: 2007
    ..methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for infants undergoing cardiopulmonary bypass...
  17. MECHANISMS OF ISCHEMIA REPERFUSION INJURY IN THE LIVER
    JOHN ENGELHARDT; Fiscal Year: 2004
    ..abstract_text> ..