reperfusion injury

Summary

Summary: Functional, metabolic, or structural changes, including necrosis, in ischemic tissues thought to result from REPERFUSION to ischemic areas of the tissue. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Top Publications

  1. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
  2. ncbi Retinal ischemia: mechanisms of damage and potential therapeutic strategies
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Retin Eye Res 23:91-147. 2004
  3. pmc The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
  4. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
  5. ncbi Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells
    Vincenzo Cantaluppi
    Dialysis and Kidney Transplantation Unit, Department of Internal Medicine, Center for Experimental Medical Research CeRMS and Nephrology, University of Torino, Torino, Italy
    Kidney Int 82:412-27. 2012
  6. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
  7. ncbi Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1
    Bo Xu
    Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
    J Surg Res 166:e157-64. 2011
  8. pmc Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency
    Fei Zhou
    Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
    J Appl Physiol (1985) 111:1877-87. 2011
  9. pmc Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
    Thorsten Berger
    The Campbell Family Institute for Breast Cancer Research and the Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 103:1834-9. 2006
  10. ncbi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008

Detail Information

Publications368 found, 100 shown here

  1. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
    ....
  2. ncbi Retinal ischemia: mechanisms of damage and potential therapeutic strategies
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Retin Eye Res 23:91-147. 2004
    ..Given the increasing understanding of the events involved in ischemic neuronal injury it is hoped that clinically effective treatments for retinal ischemia will soon be available...
  3. pmc The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
    ..Together, these results demonstrate that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process...
  4. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-..
  5. ncbi Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells
    Vincenzo Cantaluppi
    Dialysis and Kidney Transplantation Unit, Department of Internal Medicine, Center for Experimental Medical Research CeRMS and Nephrology, University of Torino, Torino, Italy
    Kidney Int 82:412-27. 2012
    ..Here, we tested whether these microvesicles prevent acute kidney injury in a rat model of ischemia-reperfusion injury. The RNA content of microvesicles was enriched in microRNAs (miRNAs) that modulate proliferation, ..
  6. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation...
  7. ncbi Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1
    Bo Xu
    Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
    J Surg Res 166:e157-64. 2011
    Systemic inflammatory response following ischemia-reperfusion injury (IRI) to a specific organ may cause injuries in multiple remote organs...
  8. pmc Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency
    Fei Zhou
    Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
    J Appl Physiol (1985) 111:1877-87. 2011
    ..Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA...
  9. pmc Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
    Thorsten Berger
    The Campbell Family Institute for Breast Cancer Research and the Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 103:1834-9. 2006
    ..Another important function ascribed to lipocalin 2 has been its protective role against kidney ischemia-reperfusion injury. We analyzed Lcn2-/- mice using a mouse model for severe renal failure and could not detect any significant ..
  10. ncbi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008
    ..a critical period of ischemia results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury. Ischemia reperfusion injury is often seen in organ transplants, major organ resections and in shock...
  11. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
    ..These data imply that TLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury...
  12. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
    ..MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles...
  13. ncbi Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury
    Florian Tögel
    Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Renal Physiol 292:F1626-35. 2007
    ..that mesenchymal stem cells (MSC), unlike fibroblasts, are significantly renoprotective after ischemia-reperfusion injury and concluded that this renoprotection is mediated primarily by paracrine mechanisms...
  14. ncbi Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Kidney Int 81:751-61. 2012
    Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death, but the contribution of necroptosis, a newly discovered form of programmed necrosis, has not been evaluated...
  15. ncbi Apoptosis and necrosis in the liver: a tale of two deaths?
    Harmeet Malhi
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 43:S31-44. 2006
    ....
  16. ncbi Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway
    Yajing Yuan
    Department of Anesthesiology, Xiangya Hospital of Central South University, Hunan 410008, China
    Brain Res 1367:85-93. 2011
    ..These results suggest that Postcond protects brain from I/R injury by suppressing ER stress-induced apoptosis and PI3K/Akt pathway is involved...
  17. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  18. ncbi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  19. pmc Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
    Craig Brooks
    Department of Cellular Biology and Anatomy, Medical College of Georgia, and Charlie Norwood VA Medical Center, Augusta, 30912, USA
    J Clin Invest 119:1275-85. 2009
    ....
  20. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..Using a mouse model of severe renal failure, ischemia-reperfusion injury, we show that a single dose of Ngal (10 microg), introduced during the initial phase of the disease, ..
  21. pmc Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats
    Yanlin Chen
    Department of Pathology, Chongqing Medical University, Chongqing, People s Republic of China
    PLoS ONE 7:e40165. 2012
    ..However, little is known about the underlying mechanisms. Here we put forward the hypothesis that TSA acts through inhibition of MIF expression during focal cerebral I/R injury in rats...
  22. pmc MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis
    Yanjun Qin
    Department of Emergency, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
    Int J Med Sci 9:413-23. 2012
    ..To determine the role of microRNA 21(miR-21) on left ventricular remodeling of rat heart with ischemia-reperfusion (I/R) injury and to investigate the underlying mechanism of miR-21 mediated myocardium protection...
  23. pmc Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
    Yen Ta Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 9:51. 2011
    ..We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury...
  24. ncbi High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    ..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
  25. ncbi Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Physiol Gastrointest Liver Physiol 284:G15-26. 2003
    Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation...
  26. pmc Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    Mark R Duranski
    Department of Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    J Clin Invest 115:1232-40. 2005
    ..These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states...
  27. ncbi Toll-like receptors in ischemia-reperfusion injury
    Thiruma V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Shock 32:4-16. 2009
    ..A greater understanding of the role of TLRs in I/R injuries may aid in the development of specific TLR-targeted therapeutics to treat these conditions...
  28. pmc High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
    John Evankovich
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 285:39888-97. 2010
    ..Together, these findings suggest that decreased nuclear HDAC1 and HDAC4 activities in hepatocytes following liver I/R is a mechanism that promotes the hyperacetylation and subsequent release of HMGB1...
  29. ncbi Delayed graft function in kidney transplantation
    Norberto Perico
    Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Lancet 364:1814-27. 2004
    ..Elucidation of the pathophysiology of renal ischaemia and reperfusion injury has contributed to the development of strategies to decrease the rate of delayed graft function, focusing on ..
  30. pmc Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation
    Thomas H Sanderson
    Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Neurobiol 47:9-23. 2013
    ..Mitochondria play a critical role in reperfusion injury by producing excessive reactive oxygen species (ROS) thereby damaging cellular components, and initiating ..
  31. pmc Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Transplant Rev (Orlando) 26:103-14. 2012
    ..potential therapeutic targets, an increased focus must be placed on more in-depth mechanistic investigations in hepatic ischemia-reperfusion injury and translational research in order to refine current strategies in disease management.
  32. pmc Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus
    Ketan Chu
    Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, 76 Qingchun Road, Hangzhou 310003, China
    J Neuroinflammation 9:69. 2012
    ....
  33. pmc Delayed graft function in the kidney transplant
    A Siedlecki
    Nephrology Division, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA
    Am J Transplant 11:2279-96. 2011
    ..pathologic contributors derived from the donor (ischemic injury, inflammatory signaling) and recipient (reperfusion injury, the innate immune response and the adaptive immune response)...
  34. pmc Macrophages, dendritic cells, and kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Semin Nephrol 30:268-77. 2010
    ..early initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury. They are the most abundant leukocytes present in the kidney, and they represent a heterogeneous population ..
  35. ncbi Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    Lele Ji
    Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 298:E871-80. 2010
    ..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
  36. ncbi Transient limb ischemia induces remote ischemic preconditioning in vivo
    R K Kharbanda
    University College, London, UK
    Circulation 106:2881-3. 2002
    ..We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size...
  37. ncbi Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection
    Narci C Teoh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 18:891-902. 2003
    This review highlights recent advances in our understanding of mechanisms underlying reperfusion injury to the liver after warm hepatic ischemia...
  38. ncbi Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 2:486-93. 2006
    ..reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-order reaction ..
  39. ncbi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia...
  40. ncbi Ischemia-reperfusion-induced lung injury
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 167:490-511. 2003
    ..Over the past decade, better understanding of the mechanisms of ischemia-reperfusion injury, improvements in the technique of lung preservation, and the development of a new preservation solution ..
  41. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    ....
  42. ncbi Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
    P J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    J Neurochem 78:1389-99. 2001
    ..Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to the extreme oxidative stress that is released during ischemia/reperfusion injury.
  43. ncbi Hepatic ischemia-reperfusion injury
    F Serracino-Inglott
    Division of Surgery, Anaesthetics, and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Surg 181:160-6. 2001
    ..morbidity associated with liver transplantation and major hepatic resections is partly a result of ischemia-reperfusion injury. DATA SOURCES: The entire world literature on the subject was searched via Medline...
  44. pmc Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury
    Suk Yee Li
    Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e16380. 2011
    ..The present study suggests that LBP may have a neuroprotective role to play in ocular diseases for which I/R is a feature...
  45. pmc Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
    Wilhelm J Schwaeble
    Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:7523-8. 2011
    ..lectin-associated serine protease-2 (MASP-2), and analyzed the role of MASP-2 in two models of postischemic reperfusion injury (IRI)...
  46. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  47. ncbi DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury
    Lorenzo L F Glorie
    Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Am J Physiol Renal Physiol 303:F681-8. 2012
    ..Inhibition of DPP4 exhibits protective effects on ischemia-reperfusion injury (IRI) of the heart and lung...
  48. ncbi NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury
    Pamela W M Kleikers
    Vascular Drug Discovery Group, Department of Pharmacology and Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    J Mol Med (Berl) 90:1391-406. 2012
    Ischemia/reperfusion injury (IRI) is crucial in the pathology of major cardiovascular diseases, such as stroke and myocardial infarction...
  49. ncbi Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans
    Stavros P Loukogeorgakis
    Institute of Child Health, University College London, UK
    Circulation 121:2310-6. 2010
    ..These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive...
  50. ncbi Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury
    Hon Kan Yip
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Pineal Res 54:207-21. 2013
    ..001 in each case). In conclusion, when the animals were treated with melatonin, the apoptotic ADMSC were superior to normal ADMSC for protection of lung from acute IR injury...
  51. ncbi Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats
    Yong Man Zhu
    Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Brain Res 1494:1-8. 2013
    ..Our data demonstrated that treatment with Dex reduced cerebral injury in rats exposed to transient focal I/R, and this was mediated by the activation of the PI3K/Akt and ERK1/2 pathways as well the phosphorylation of downstream GSK-3β...
  52. ncbi Retinal protection from acute glaucoma-induced ischemia-reperfusion injury through pharmacologic induction of heme oxygenase-1
    Ming Hui Sun
    Department of Ophthalmology, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
    Invest Ophthalmol Vis Sci 51:4798-808. 2010
    ..effects of cobalt protoporphyrin (CoPP), a potent heme oxygenase (HO)-1 inducer, in a rat model of ischemia-reperfusion injury and to document the possible antiapoptotic and anti-inflammatory mechanisms underlying the protection.
  53. pmc Identification of a microRNA signature of renal ischemia reperfusion injury
    Jonathan G Godwin
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14339-44. 2010
    Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined expression profiles of miRNAs following renal IRI...
  54. pmc miR-1 exacerbates cardiac ischemia-reperfusion injury in mouse models
    Zhenwei Pan
    Department of Pharmacology Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang, People s Republic of China
    PLoS ONE 7:e50515. 2012
    ..oligonucleotide against miR-1 (LNA-antimiR-1) were used to explore the effects of miR-1 on cardiac ischemia/reperfusion injury (30 min ischemia followed by 24 h reperfusion)...
  55. ncbi Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction
    Juhyun Park
    School of Pharmacy, Sungkyunkwan University, Gyeonggi Do, Suwon 440 746, Republic of Korea
    Eur J Pharmacol 707:61-70. 2013
    ..Our findings suggest that activation of α7 nicotinic acetylcholine receptor by nicotine ameliorates I/R-induced liver injury, and that this protection is likely due to inhibition of the inflammatory response through HO-1 induction...
  56. ncbi NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J W Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Stroke 38:3000-6. 2007
    ..We hypothesized that NADPH oxidases mediate blood-brain barrier (BBB) disruption and contribute to tissue damage in ischemia/reperfusion...
  57. ncbi Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F713-22. 2007
    ..In particular, neutrophil, macrophage, and NK1.1+ lymphocyte cell modulation may play a significant role in renal protection by isoflurane anesthesia...
  58. ncbi Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
    Nari Yun
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, South Korea
    J Nutr Biochem 23:1249-55. 2012
    Hepatic ischemia and reperfusion injury (I/R) is accompanied by excessive reactive oxygen species and resultant sterile inflammation...
  59. pmc Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
    Michael Brines
    Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 105:10925-30. 2008
    ..Thus, the tissue-protective activities of EPO are mimicked by small, nonerythropoietic peptides that simulate a portion of EPO's three-dimensional structure...
  60. pmc Role of glycogen synthase kinase-3beta in cardioprotection
    Magdalena Juhaszova
    Laboratory of Cardiovascular Science, Gerontology Research Center, Box 13, National Institute on Aging, NIH, Baltimore, Maryland 21224 6825, USA
    Circ Res 104:1240-52. 2009
    ....
  61. pmc Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury
    Galina Dvoriantchikova
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 16:1907-12. 2010
    ..We investigated whether retinal ischemia and inflammation produced by raising the intraocular pressure above normal systolic levels differs in mice that lack a functional toll-like receptor 4 (Tlr4) signaling pathway...
  62. ncbi Calcium, mitochondria and reperfusion injury: a pore way to die
    A P Halestrap
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochem Soc Trans 34:232-7. 2006
    ..Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke...
  63. ncbi Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling
    Heng Chao Yu
    State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Xi Jing Hospital, Fourth Military Medical University, Xi an, China
    Hepatology 54:979-88. 2011
    ..Finally, forced Notch activation by ligand stimulation or Hes5 overexpression reduced intracellular ROS and protected hepatocytes from apoptosis after I/R injury through the activation of STAT3 and MnSOD expression...
  64. pmc Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
    Andreas Linkermann
    Division of Nephrology and Hypertension and Institute for Pathology, Christian Albrechts University, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 110:12024-9. 2013
    ..Here, we demonstrate that necroptosis in ischemia-reperfusion injury (IRI) in mice occurs as primary organ damage, independent of the immune system, and that mice deficient for ..
  65. ncbi Erythropoietin ameliorates renal ischemia and reperfusion injury via inhibiting tubulointerstitial inflammation
    Linkun Hu
    Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, PR China
    J Surg Res 176:260-6. 2012
    Tubulointerstitial inflammation is the characteristics of renal ischemia reperfusion injury (IRI) that is inevitable in kidney transplantation...
  66. ncbi A lipoxin A4 analog ameliorates blood-brain barrier dysfunction and reduces MMP-9 expression in a rat model of focal cerebral ischemia-reperfusion injury
    Yan Wu
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1277, Jiefang Avenue, Wuhan, 430022, China
    J Mol Neurosci 46:483-91. 2012
    ..Furthermore, these results suggest that LXA(4)ME-mediated reduction of MMP-9 following stroke are attributed to increased TIMP-1 expression...
  67. ncbi Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways
    Robert F Schwabe
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006
    ..In light of recent findings, pharmacological inhibitors of JNK and IKK and antioxidants may be promising new tools for the treatment of hepatitis, ischemia-reperfusion injury, and hepatocellular carcinoma.
  68. ncbi Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury
    Yong Gu
    School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 120:147-56. 2012
    ..and the production of nitric oxide (NO) induced the loss of cav-1 in focal cerebral ischemia and reperfusion injury. The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix ..
  69. ncbi Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling
    Chih Ching Yang
    Department of Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Transplantation 88:1251-60. 2009
    ..We hypothesized that repetitive hypoxic preconditioning (RHP) may provide long-lasting protection than single preconditioning against ischemia/reperfusion injury in rat kidneys through hypoxia-induced factor (HIF)-1-dependent pathway.
  70. ncbi 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway
    Yan Zhang
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Mol Cell Cardiol 49:576-86. 2010
    ..that high concentrations of aldehydes are responsible for much of the damage elicited by cardiac ischemia-reperfusion injury, while sublethal concentrations of aldehydes stimulate stress resistance pathways, to achieve ..
  71. pmc An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
    Alana A Shigeoka
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:6277-85. 2010
    ..To examine the role of the inflammasome in renal ischemia-reperfusion injury (IRI) we also tested its downstream targets caspase 1, IL-1β, and IL-18...
  72. pmc Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation
    Y Zhai
    The Dumont UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Transplant 11:1563-9. 2011
    Ischemia and reperfusion injury (IRI) is a dynamic process that involves two distinctive yet interrelated phases of ischemic organ damage and inflammation-mediated reperfusion injury...
  73. ncbi Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
    ..Two days after ischemia-reperfusion injury (IRI), 50...
  74. ncbi Reactive oxygen species and the modulation of stroke
    Peter J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, VIC 3168, Australia
    Free Radic Biol Med 38:1433-44. 2005
    ..that is partially regulated via oxidative state and, in an oxidative stress paradigm such as ischemic reperfusion injury, may be inactivated, which can lead to potentiation and or exacerbation of cell death...
  75. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma
    Yuan Ji Day
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 176:3108-14. 2006
    ..bone marrow (BM)-derived cells contribute to the renal protective effect of A(2A) agonists in renal ischemia-reperfusion injury (IRI)...
  76. pmc HMGB1 contributes to kidney ischemia reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
    J Am Soc Nephrol 21:1878-90. 2010
    ..TLR4 activation mediates kidney ischemia-reperfusion injury (IRI), but whether HMGB1 contributes to IRI is unknown...
  77. ncbi Ischemia-reperfusion injury of the intestine and protective strategies against injury
    Ismail Hameed Mallick
    GI and Hepatobiliary Research Unit, University Department of Surgery, Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Dig Dis Sci 49:1359-77. 2004
    Ischemia-reperfusion injury of the intestine is a significant problem in abdominal aortic aneurysm surgery, small bowel transplantation, cardiopulmonary bypass, strangulated hernias, and neonatal necrotizing enterocolitis...
  78. ncbi P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor
    K J Kelly
    Indiana Center for Biological Microscopy, Department of Medicine, Division of Nephrology, Indiana University, Indianapolis Indiana 46202, USA
    J Am Soc Nephrol 14:128-38. 2003
    ..It is concluded that p53 is an important mediator of apoptosis during states of GTP depletion. Inhibitors of p53 should be considered in the treatment of ischemic renal injury...
  79. ncbi Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
    Hartmut Jaeschke
    Liver Research Institute, University of Arizona, College of Medicine, Room 6309, 1501 N Campbell Avenue, Tucson, Arizona, USA
    Gastroenterology 125:1246-57. 2003
    ..However, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.
  80. pmc HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 31:593-605. 2011
    ..These results suggest that HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling...
  81. ncbi Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury
    Julia Biermann
    University Eye Hospital Freiburg, University Medical Center, Killianstrasse 5, 79106 Freiburg, Germany
    Invest Ophthalmol Vis Sci 51:3784-91. 2010
    ..Further studies are needed to evaluate whether CO posttreatment may represent a therapeutic option counteracting ischemic neuronal injury...
  82. ncbi Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm
    Stavros P Loukogeorgakis
    Vascular Physiology Unit, Institute of Child Health, University College London, London, WC1N 3JE, United Kingdom
    Circulation 113:1015-9. 2006
    ..The aim of this study was to determine whether postconditioning protects against endothelial IR injury in humans, in vivo...
  83. ncbi Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  84. ncbi Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system
    Stavros P Loukogeorgakis
    Vascular Physiology Unit, Institute of Child Health, University College London, London, United Kingdom
    J Am Coll Cardiol 46:450-6. 2005
    ..The aim of this study was to characterize the time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in humans...
  85. pmc Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
    Fangming Lin
    Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
    J Clin Invest 115:1756-64. 2005
    ..Following ischemia/reperfusion injury (IRI), EGFP-positive cells showed incorporation of BrdU and expression of vimentin, which provides direct ..
  86. pmc Factors in the pathophysiology of the liver ischemia-reperfusion injury
    Eduardo E Montalvo-Jave
    Department of Surgery, National Autonomous University of Mexico, Mexico City, Mexico
    J Surg Res 147:153-9. 2008
    Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma...
  87. pmc Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation
    Deepu R Pillai
    Department of Neurology, Regensburg University Medical Center, Regensburg, Germany
    J Cereb Blood Flow Metab 29:1846-55. 2009
    ..Stroke therapy aimed at vasogenic edema and drug delivery for neuroprotection may also be guided according to the functional status of the BBB, and these findings have to be confirmed in human stroke...
  88. ncbi Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
    Kouki Fukuda
    Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 51:3629-38. 2010
    ..an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II antagonist against retinal ischemia-reperfusion injury in the rat retina. METHODS. Retinal ischemia was induced by increasing intraocular pressure to 130 mm Hg...
  89. pmc Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts
    Christopher D Anderson
    Departments of Surgery, Washington University, St Louis, MO 63110, USA
    Liver Transpl 17:189-200. 2011
    ..These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft...
  90. ncbi ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats
    Kátia D da Silveira
    Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Clin Sci (Lond) 119:385-94. 2010
    ..In conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin-angiotensin system)-related peptidases support an important role for the ACE2-Ang-(1-7)-Mas axis in AKI...
  91. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011
    ..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease...
  92. pmc Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    Yunwei Wei
    Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
    BMC Gastroenterol 10:42. 2010
    Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure...
  93. ncbi Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells
    Sergey V Brodsky
    Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8152, USA
    Am J Physiol Renal Physiol 282:F1140-9. 2002
    ..These observations strongly suggest that endothelial cell dysfunction is the primary cause of the no-reflow phenomenon, which, when ameliorated, results in prevention of renal injury seen in acute renal failure...
  94. ncbi Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury
    M Lv
    Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China
    Neuroscience 176:162-72. 2011
    ..TLR2 activation results in IL-23 production which stimulates IL-17 production by microglia. This microglial axis may be a potential therapeutic target to control neuroinflammation in brain IR...
  95. ncbi Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury
    Martin Schneider
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    Gastroenterology 138:1143-54.e1-2. 2010
    ..We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and protect them against hepatic I/R damage...
  96. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A(2A)) receptors (A(2A)Rs) mediates tissue protection...
  97. ncbi Hemeoxygenase-1 and renal ischaemia-reperfusion injury
    David A Ferenbach
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    Nephron Exp Nephrol 115:e33-7. 2010
    ..efficacy of strategies to upregulate enzyme activity in ameliorating the severity of experimental ischaemia-reperfusion injury whilst genetic ablation of HO-1 or pharmacological inhibition of HO-1 activity results in an augmented ..
  98. pmc The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury
    Hongbao Liu
    Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e34608. 2012
    ..These results advance our knowledge about SDF-1-CXCR4/CXCR7 axis as an attractive target pathway for improving the beneficial effects of MSC-based therapies for renal I/R...
  99. pmc Molecular mechanisms of liver preconditioning
    Elisa Alchera
    Department of Medical Sciences, University of East Piedmont A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    World J Gastroenterol 16:6058-67. 2010
    ....
  100. pmc Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model
    Hiroyuki Kanazawa
    Division of Development of Advanced Treatment, Center for Development of Advanced Medical Technology, Jichi Medical University, Yakushiji City, Tochigi, Japan
    PLoS ONE 6:e19195. 2011
    ..Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy...
  101. ncbi GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury
    Rosanna Di Paola
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Leukoc Biol 88:291-301. 2010
    ..Based on these findings, we propose that GW0742 would be useful in the treatment of various I/R diseases...

Research Grants78

  1. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may involve ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Myocardial ischemia/reperfusion injury occurs in a wide spectrum of patients, ranging from survivors of out- of-hospital cardiac arrest to AMI ..
  3. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..RTX) is developing a novel bifunctional small molecule, R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation...
  4. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  5. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..maintenance of or improvement in islet function and to define the effect of aMSC third party MSC on ischemia reperfusion injury. Aim 3...
  6. THE ROLE OF ACETYLATION IN MITOCHONDRIAL FUNCTION
    Gary Cecchini; Fiscal Year: 2013
    ..cells, studies will be undertaken to investigate how acetylation affects the response in a cardiac ischemia/reperfusion injury model...
  7. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..In support of this approach, in a rodent model of renal ischemia/reperfusion injury R- 801 profoundly reduced the elevation in BUN and creatinine, blocked neutrophil inflammation, and ..
  8. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..or deficient and both of these have been implicated in bacterial, viral and parasitic infections, ischemia-reperfusion injury, inflammatory bowel disease, celiac disease and colorectal cancer...
  9. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  10. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..Interruption and subsequent restoration of circulation in tissues causes varying amounts of ischemia- reperfusion injury (IRI)...
  11. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..Oxidant stress has been implicated in the cellular dysfunction associated with ischemia- reperfusion injury, vascular disease, stroke, diabetes, neurodegenerative diseases, liver disease, renal disease, inflammation, ..
  12. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..Since NPD1 and AT-NPD1 are both produced during reperfusion injury, our plan consists of four interrelated Research and Development Innovation goals, which include defining ..
  13. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..stem cell differentiation, using genetically modified mice and mouse models of heart failure and ischemia/reperfusion injury. The knowledge obtained from this investigation should be useful for the development of better treatment for ..
  14. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Radikal Therapeutics (RTX) is developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  15. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Reactive oxygen species (ROS) are released acutely in large amounts during ischemia or ischemia/reperfusion injury. Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (..
  16. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..SDF1 is under active investigation as a treatment for prevention of myocardial ischemia/reperfusion injury. Experiments in aim 2 will define the GAG binding site on the SDF1 dimer and use this knowledge to construct ..
  17. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Ischemia/reperfusion injury occurring in heart attack, stroke and complications of diabetes is one of the leading causes of suffering ..
  18. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..apoptosis contributes to adverse ventricular remodeling after myocardial infarction and myocardial ischemia-reperfusion injury. We have developed microsurgical procedures to generate myocardial infarction and ischemia-reperfusion ..
  19. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Title of grant: Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Ischemia-reperfusion (I/R) injury to vital organs and tissue can occur in a variety of clinical ..
  20. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..etiology of intestinal cell necrosis is uncertain, risk factors include anisotonic fluids, toxins, ischemia- reperfusion injury and reactive oxygen species...
  21. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..of the HIF-1/prolyl hydroxylase oxygen-sensing signal cascade blocks the MPT and minimizes storage/reperfusion injury to liver grafts...
  22. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury. Interestingly, in vivo studies have demonstrated that genetic ablation or pharmacological inhibition of ..
  23. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury. Inflammation and oxidative stress are key mediators in this process...
  24. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..Kupffer cells and neutrophils contribute to a wide variety of liver pathologies including hepatic ischemia-reperfusion injury (transplantation, tumor resections), alcoholic hepatitis, steatohepatitis and obstructive cholestasis...
  25. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..towards compromised tissues after an ischemic attack (a deleterious effect), such as in the case of ischemia/reperfusion injury (I/RI) in the heart...
  26. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    Sponsor Abstract Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased ..
  27. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  28. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..At the present time, there is no clinically reliable means to prevent ischemia/reperfusion injury to the myocardium...
  29. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ..We have also demonstrated that hyperglycemia, a known stroke risk factor, exacerbated reperfusion injury by enhancing MMP-9 activation, BBB damage, and neuronal death by an oxidative stress mechanism that may ..
  30. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..where ROS play an important role in the pathology of the disease, such as those involving ischemia reperfusion injury (Specific Aim 1), and to initially characterize the pharmacological basis of this effect (Specific Aim 2)...
  31. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..While the exact mechanisms of ischemia/reperfusion injury remain unclear, inhibition of complement activation (e.g...
  32. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..3) the role of the transcription factor Stat3 in mediating the inflammatory response to myocardial ischemia-reperfusion injury, (4) the role of endothelial cell exocytosis in mediating inflammation after ischemia-reperfusion, and (5) ..
  33. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..hypertension, or kidneys subjected to prolonged cold ischemia and exhibiting increased ischemia-normothermic reperfusion injury and delayed graft function, therefore necessitating dialysis in the recipient...
  34. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..Ischemia-reperfusion injury associated with these conditions can lead to permanent tissue damage or neurologic deficits...
  35. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..Moreover, successful recanalization causes detrimental reperfusion injury that accounts for up to 50% of the final size of a myocardial infarct...
  36. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute limb ischemia reperfusion injury (LIRI) is characterized by an imbalance in the free radicals nitric oxide and superoxide anion...
  37. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..We will study hepatic lesions, mt-dysfunction, myocardial ischemia/reperfusion injury in alcohol-treated or alcohol + LPS treated rats...
  38. Role of The Jak-Stat Pathway in Ischemic Preconditioning
    Yu Ting Xuan; Fiscal Year: 2010
    ..Although apoptosis has been shown to play a crucial role in cell death after ischemia/reperfusion injury, it remains largely unknown whether late PC protects against cardiac apoptosis and what signaling/molecular ..
  39. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..In rats subjected to renal ischemia/reperfusion injury (RIRI), IV administration of R-100 prior to reperfusion reduced the 6 h elevations in serum creatinine, ..
  40. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..of ATP sensitive K+ channels (KATP channels) in H2S- mediated cardioprotection against myocardial ischemia-reperfusion injury. In vitro studies will evaluate the effects of H2S on KATP channel activation and mitochondrial function...
  41. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..occurring IgM anti-leucocyte autoantibodies in inhibiting inflammatory processes that occur after ischemia-reperfusion injury (IRI)...
  42. Contractile Regulation of Cardiocyte Protein Synthesis
    Paul J McDermott; Fiscal Year: 2013
    ..Companion studies will be done using a murine model of myocardial ischemia and ischemia/reperfusion injury establish the physiological significance of the adult cardiomyocyte model to oxidative stress in vivo...
  43. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myocardial ischemia-reperfusion injury is the most common cause of death in the US...
  44. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ....
  45. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..5 billion per year. Ischemia-reperfusion injury is the major cause of complications of cardiac surgery;morbidity and mortality, but current cardioprotective ..
  46. Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA Damage
    Narsing A Rao; Fiscal Year: 2010
    ..systemic diseases, TLRs activation has been implicated in the pathogenesis of CNS demyelination, ischemia/reperfusion injury of the organs, and age-related macular degeneration...
  47. Sphingolipids in Acute Kidney Injury
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..These compounds abrogate the pathology associated with ischemia-reperfusion injury (IRI) of the kidney and other organs...
  48. Mechanisms and Functions of Bimodally Targeted Cytochrome P450s to Mitochondria
    Narayan G Avadhani; Fiscal Year: 2012
    ..Finally, the role of mitochondria targeted CYPs in ischemia reperfusion injury will be studied using cell and animal models.
  49. MicroRNA-21 in Renal Aging
    Markus Bitzer; Fiscal Year: 2012
    ..to failure to recover kidney function and CKD have been identified using animal models including ischemia-reperfusion injury. Increased apoptosis, inflammation and deposition of extracellular matrix result in renal fibrosis and renal ..
  50. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2012
    ..Myocardial ischemia/reperfusion injury is still a major unsolved problem...
  51. Mechanism of Neutrophil Activation
    Kenneth R McLeish; Fiscal Year: 2013
    ..of diseases prominent in the aging Veteran population, including ANCA-associated vasculitis, ischemia- reperfusion injury, acute respiratory distress syndrome, rheumatoid arthritis, peridontitis, atherosclerosis, and acute ..
  52. Myocardial Injury Associated with Mitochondria-derived Oxygen Free Radical(s)
    Yeong Renn Chen; Fiscal Year: 2013
    ..the mitochondrial complex I (NQR), complex II (SQR), and other ETC proteins during myocardial ischemia and reperfusion injury. Alterations of NQR/SQR-derived oxidative modifications are closely linked to oxygen free radical production,..
  53. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..Aim 3 will examine the cardioprotective effects of GLP-1 in obese/MetS heart following ischemia/reperfusion injury. We propose to quantify the effects of GLP-1 and GLP-1(9-36) on myocardial perfusion, substrate and ..
  54. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..as an effector arm of antibody initiated injury to a transplant, graft-derived complement impacts ischemia reperfusion injury, regulates B cell activation and antibody isotype switching and influences alloreactive T cell immunity...
  55. Genetic Control of Heart Function in a Hibernating Mammal
    Matthew T Andrews; Fiscal Year: 2010
    ..and lipid composition provide protection against myocardial damage normally associated with ischemia and reperfusion injury. High-throughput instrumentation and advances in computational power have placed us in a unique position to ..
  56. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  57. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Pittsburgh
    Clifton W Callaway; Fiscal Year: 2013
    ..renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline ..
  58. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2013
    ..renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline ..
  59. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..And 4) increases the reparative function of human diabetic CD34 EPC in SCID mice following ischemia/ reperfusion injury. Overall Hypothesis: Transient blockade of endogenous transforming growth factor-beta type 1 (TGF-b1) using ..
  60. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..S1P was sufficient to decrease infarction and enhance contractility in mouse hearts subjected to ischemia-reperfusion injury. We also developed a rapid and accurate radioassay for measurement of sphingosine kinase activity and ..
  61. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
  62. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium...
  63. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Ischemia-reperfusion injury (IRI) is a major problem in many clinical scenarios, including myocardial infarction and stroke...
  64. Prevention of ischemia reperfusion injury associated with acute myocardial infarc
    Craig Sherman; Fiscal Year: 2010
    ..and owns patent rights to a recently discovered use for sodium nitrite as a means to prevent ischemia-reperfusion injury. Ischemia-reperfusion injury refers to tissue damage caused when blood supply returns to the tissue after a ..
  65. PRESERVATION OF THE ISCHEMIC/REPERFUSED MYOCARDIUM
    Michael Hess; Fiscal Year: 1990
    ..generation of cytotoxic oxygen free radicals occupies an important role in the pathophysiology of ischemic/reperfusion injury. Our previous work has developed the working hypothesis that myocardial ischemia results in the ..
  66. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    GREGORY STAHL; Fiscal Year: 2009
    While the exact mechanisms of ischemia/reperfusion injury remain unclear, our laboratory and others have shown that inhibition of complement activation (e.g., sCR1 or C1 esterase inhibitor), depletion of complement components (e.g...
  67. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1991
    ..events and/or anatomic changes occur with reperfusion that may limit the amount of salvageable myocardium ("reperfusion injury")...
  68. REGULATION OF E-SELECTIN DURING ACUTE INFLAMMATION
    Kevin Billups; Fiscal Year: 1999
    ..In addition to acute infectious etiologies, it is becoming increasingly clear that ischemia/reperfusion injury triggers a striking acute inflammatory response that contributes to tissue damage and organ failure...
  69. ISCHEMIA-REPERFUSION INJURY AFTER LUNG TRANSPLANTATION
    Joel Cooper; Fiscal Year: 1991
    ..of lung transplantation, the so-called "reimplantation response", is in fact a manifestation of ischemia-reperfusion injury to the transplanted lung...
  70. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ischemia-reperfusion injury (IRI) occurs in organs when circulation is interrupted, causing ischemia, and then ischemic tissue is reperfused...
  71. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..A key goal of preconditioning is to reduce the damage inflicted by ischemia-reperfusion injury (IRI) that occurs when the ischemic/ hypoxic organ is connected to the recipient's circulation...
  72. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..However there have been limited studies of ischemia-reperfusion injury in in vivo aged myocardium and few systematic investigations of mitochondrial function in intact ventricular ..
  73. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..inhibition of this pathway can help define the mechanisms regulating CD62P and its role in PMN-mediated reperfusion injury, potentially leading to modulation of PMN-mediated injury...