Summary: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Top Publications

  1. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
  2. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
  3. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
  4. ncbi Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
    Sheng Kwei Song
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:1714-22. 2003
  5. ncbi Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Med 9:1370-6. 2003
  6. doi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008
  7. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  8. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
  9. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  10. ncbi Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circ Res 94:678-85. 2004

Research Grants

Detail Information

Publications456 found, 100 shown here

  1. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
    ..Bone marrow cell therapy is reported to contribute to collateral formation through cell incorporation into new or remodeling vessels. However, the possible role of a paracrine contribution to this effect is less well characterized...
  2. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ..One week after the onset of hindlimb ischemia, lacZ-positive EPCs were identified incorporated into capillaries among skeletal myocytes...
  3. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
    b>Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease ..
  4. ncbi Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
    Sheng Kwei Song
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:1714-22. 2003
    ..and myelin pathologies, respectively, the optic nerve was examined serially using DTI in a mouse model of retinal ischemia. A significant decrease of lambdaparallel, the putative DTI axonal marker, was observed 3 days after ischemia ..
  5. ncbi Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Med 9:1370-6. 2003
    ..bone marrow transplantation, rescued the defective neovascularization of Nos3(-/-) mice in a model of hind-limb ischemia, suggesting that progenitor mobilization from the bone marrow is impaired in Nos3(-/-) mice...
  6. doi Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review
    Niteen Tapuria
    Institute Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom
    J Surg Res 150:304-30. 2008
    Restoration of blood supply to an organ after a critical period of ischemia results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury...
  7. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  8. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  9. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  10. ncbi Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circ Res 94:678-85. 2004
    ..Using a murine hindlimb ischemia model, murine MSC(CM) enhanced collateral flow recovery and remodeling, improved limb function, reduced the ..
  11. pmc HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 204:2913-23. 2007
    ..We elucidate the mechanism by which HMGB1, one of the key alarm molecules released during liver ischemia/reperfusion (I/R), is mobilized in response to hypoxia...
  12. pmc Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    Hirokazu Ohtaki
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 105:14638-43. 2008
    ..mesenchymal stromal cells (hMSCs) were injected into the hippocampus of adult mice 1 day after transient global ischemia. The hMSCs both improved neurologic function and markedly decreased neuronal cell death of the hippocampus...
  13. doi Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia
    Simona Greco
    Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Milan, Italy
    FASEB J 23:3335-46. 2009
    ..pathological pathways activated in skeletal muscle damage and regeneration by both dystrophin absence and acute ischemia. Eleven miRNAs were deregulated both in MDX mice and in Duchenne muscular dystrophy patients (DMD signature)...
  14. ncbi Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    Chang Hwan Yoon
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Circulation 112:1618-27. 2005
    ..We also investigated whether the combination of these different cell types shows synergism during neovascularization...
  15. doi Calcium, ischemia and excitotoxicity
    Kinga Szydlowska
    Toronto Western Hospital Research Institute, MC11 414, 399 Bathurst Street, Toronto, Ontario, Canada M5T2S8
    Cell Calcium 47:122-9. 2010
    ..However, identifying those that are most responsible for cell death and their downstream signalling pathways may lead to improved strategies for treating ischemic and excitotoxic disorders...
  16. ncbi Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies
    M Zhang
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Mol Cell Cardiol 33:907-21. 2001
    ..To test whether ischemia contributed to poor graft survival, grafts were placed into vascularized 2-week-old cardiac granulation tissue or ..
  17. ncbi SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    Elena De Falco
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Blood 104:3472-82. 2004
    ..plays a role in differentiation of BM-derived c-kit(+) stem cells into endothelial progenitor cells (EPCs) and in ischemia-induced trafficking of stem cells from PB to ischemic tissues...
  18. ncbi Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis
    Jin Hur
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Korea
    Arterioscler Thromb Vasc Biol 24:288-93. 2004
    ..Endothelial progenitor cells (EPC) in one study group is not the same as EPC in other investigators, suggesting that EPC is not a single type of cell population. In this study, we tried to demonstrate the heterogeneity of EPC...
  19. pmc Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
    T Murohara
    Department of Medicine Cardiology and Department of Cardiothoracic Surgery and Biomedical Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 101:2567-78. 1998
    ..two animal models in which therapeutic angiogenesis has been characterized as a compensatory response to tissue ischemia. We first administered L-arginine, previously shown to augment endogenous production of NO, to normal rabbits ..
  20. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  21. pmc Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond
    Lilach O Lerman
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Prog Cardiovasc Dis 52:196-203. 2009
    ..The extent to which actual ischemia modulates injury in the stenotic kidney has been controversial, partly because the decrease in renal oxygen ..
  22. doi Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation
    A A Hellingman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Vasc Endovasc Surg 40:796-803. 2010
    ..To identify the optimal mouse model for hind limb ischaemia, which offers a therapeutic window that is large enough to detect improvements of blood flow recovery, for example, using cell therapies...
  23. doi Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA)
    Dirk H Walter
    Division of Cardiology and Angiology, Department of Radiology, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Cardiovasc Interv 4:26-37. 2011
    Critical limb ischemia due to peripheral arterial occlusive disease is associated with a severely increased morbidity and mortality. There is no effective pharmacological therapy available...
  24. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  25. pmc Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo
    R Russo
    Department of Pharmacobiology, University of Calabria, Arcavacata di Rende, Italy
    Cell Death Dis 2:e144. 2011
    ..this study, we investigated the dynamics of the autophagic process in retinal tissue that has undergone transient ischemia, an experimental model that recapitulates features of ocular pathologies, including glaucoma, anterior ischemic ..
  26. pmc Vascular responses to hypoxia and ischemia
    Gregg L Semenza
    Institute for Cell Engineering, Departments of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 30:648-52. 2010
    ..Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate ..
  27. doi Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
    Hiroyasu Kidoya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Blood 115:3166-74. 2010
    The efficacy of therapeutic angiogenesis for revascularization in ischemia using genes, proteins, and cells has been established...
  28. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    Inflammation plays a major role in the pathophysiology of acute renal failure resulting from ischemia. In this review, we discuss the contribution of endothelial and epithelial cells and leukocytes to this inflammatory response...
  29. ncbi Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    S Shintani
    Cardiovascular Research Institute and the Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Circulation 103:897-903. 2001
    ..of autologous BM-MNCs might augment angiogenesis and collateral vessel formation in a rabbit model of hindlimb ischemia. METHODS AND RESULTS: Rabbit BM-MNCs were isolated by centrifugation through a Histopaque density gradient and ..
  30. ncbi Glutamate uptake
    N C Danbolt
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, N-0317, Oslo, Norway
    Prog Neurobiol 65:1-105. 2001
    ..g. cerebral ischemia, hypoglycemia, amyotrophic lateral sclerosis, Alzheimer's disease, traumatic brain injury, epilepsy and ..
  31. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1...
  32. doi Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia
    Andrea Caporali
    Regenerative Medicine, School of Clinical Medicine, University of Bristol, Bristol, England, UK
    Circulation 123:282-91. 2011
    ..microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region...
  33. ncbi Recent advances in the pathophysiology of ischemic acute renal failure
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
    J Am Soc Nephrol 14:2199-210. 2003
  34. doi Dietary nitrate supplementation improves revascularization in chronic ischemia
    Ulrike B Hendgen-Cotta
    Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Dusseldorf, Dusseldorf, Germany
    Circulation 126:1983-92. 2012
    ..Whether dietary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently to nitric oxide and other nitrogen oxides, enhances ischemia-induced remodeling of the vascular network is not known.
  35. pmc Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma
    Sebastien Le Jan
    INSERM U36, College de France, Paris
    Am J Pathol 162:1521-8. 2003
    ..In human pathology, ANGPTL4 mRNA is produced in ischemic tissues, in conditions such as critical leg ischemia. In tumors, ANGPTL4 is produced in the hypoxic areas surrounding necrotic regions...
  36. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    ..Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia.
  37. doi Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia
    Nicholas J Evennett
    Department of Surgery, Institute of Child Health, London, UK
    World J Surg 33:1374-83. 2009
    Intestinal ischemia is a potentially catastrophic abdominal emergency that presents a significant diagnostic challenge in the critical care setting...
  38. pmc Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
    Sergio Rey
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N Broadway, Baltimore, MD 21205, USA
    Cardiovasc Res 86:236-42. 2010
    ..This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models...
  39. doi Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation
    Christian Kupatt
    Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
    J Am Coll Cardiol 56:414-22. 2010
    ..adeno-associated virus [rAAV]) to induce prolonged expression of vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF)-B in a rabbit hindlimb ischemia model and a pig model of hibernating myocardium.
  40. ncbi Bone marrow-derived cells do not incorporate into the adult growing vasculature
    Tibor Ziegelhoeffer
    Max Planck Institute for Clinical and Physiological Research, Bad Nauheim, Germany
    Circ Res 94:230-8. 2004
    ..We investigated whether bone marrow-Derived cells incorporate into vessels using mouse models of hindlimb ischemia (arteriogenesis and angiogenesis) and tumor growth...
  41. pmc Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections
    Attila Cselenyák
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, H 1094, Tuzoltó utca 37 47, Budapest, Hungary
    BMC Cell Biol 11:29. 2010
    ..Using an in vitro ischemia model of 150 minutes of oxygen glucose deprivation we investigated cell viability and cell interactions with ..
  42. doi Bevacizumab increases the risk of arterial ischemia: a large study in cancer patients with a focus on different subgroup outcomes
    F A B Schutz
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, USA
    Ann Oncol 22:1404-12. 2011
    ..We did a meta-analysis of randomized controlled trials to fully characterize the arterial thromboembolic events (ATEs) risk with bevacizumab in certain patients' subgroups...
  43. pmc Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis
    Coen van Solingen
    Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands
    J Cell Mol Med 13:1577-85. 2009
    ..regeneration, mice were injected with a single dose of antagomir-126 or a control 'scramblemir' and exposed to ischemia of the left hindlimb by ligation of the femoral artery...
  44. doi Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial
    Debin Lu
    Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Diabetes Res Clin Pract 92:26-36. 2011
    To identify better cells for the treatment of diabetic critical limb ischemia (CLI) and foot ulcer in a pilot trial.
  45. doi Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    Jill Belch
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 377:1929-37. 2011
    ..Patients with critical limb ischaemia have a high rate of amputation and mortality. We tested the hypothesis that non-viral 1 fibroblast growth factor (NV1FGF) would improve amputation-free survival...
  46. doi Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice
    Jana Benesova
    Laboratory of Neurobiology, Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Neurosci Res 87:96-111. 2009
    Energy depletion during ischemia leads to disturbed ionic homeostasis and accumulation of neuroactive substances in the extracellular space, subsequently leading to volume changes in astrocytes...
  47. ncbi Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    Yi Wen
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:22684-92. 2004
    ..In this study, we report for the first time that transient cerebral ischemia induces aberrant mitotic proteins and hyperphosphorylation of tau protein with neurofibrillary tangle-like ..
  48. ncbi A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia
    Joanna Dluzniewska
    Molecular Biology Unit, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    FASEB J 19:1896-8. 2005
    ..In vivo, in a gerbil model of transient brain ischemia, treatment with the synthetic MGF C-terminal peptide provided very significant protection to the vulnerable ..
  49. ncbi High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Department of Internal Medicine III, J W Goethe University of Frankfurt, Frankfurt, Germany
    Circ Res 100:204-12. 2007
    ..These results may provide a platform for the development of novel therapeutic approaches to improve EPC homing...
  50. pmc Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia
    Jennifer E Ziello
    Department of Medicine, Vascular Biology and Transplantation Program, Yale University, New Haven, Connecticut 06520, USA
    Yale J Biol Med 80:51-60. 2007
    ..genes involved in the homeostatic process, which can increase vascularization in hypoxic areas such as localized ischemia and tumors...
  51. pmc Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion
    Benjamin J Capoccia
    Division of Oncology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Leukoc Biol 84:760-8. 2008
    There is accumulating evidence that delivery of bone marrow cells to sites of ischemia by direct local injection or mobilization into the blood can stimulate angiogenesis...
  52. doi Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells
    Po Hsun Huang
    Division of Cardiology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 29:1179-84. 2009
    ..Here we show that the impaired neovascularization in mice lacking MMP-9 is related to a defect in EPC functions in vasculogenesis...
  53. pmc Human studies of angiogenic gene therapy
    Rajesh Gupta
    Feinberg Cardiovascular Research Institute, Northwestern University and Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Circ Res 105:724-36. 2009
  54. pmc Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
    Lori A Kubasiak
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 99:12825-30. 2002
    Coronary artery disease leads to injury and loss of myocardial tissue by deprivation of blood flow (ischemia) and is a major underlying cause of heart failure...
  55. ncbi The response of the hepatocyte to ischemia
    M Massip-Salcedo
    Experimental Hepatic Ischemia Reperfusion Unit, Instituto de Investigaciones Biomédicas de Barcelona Consejo Superior de Investigaciones Científicas, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Barcelona, Spain
    Liver Int 27:6-16. 2007
    b>Ischemia-reperfusion (I/R) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice, in spite of several attempts to solve the problem.
  56. ncbi Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice
    Eugenio Stabile
    Laboratory of Vascular Biology, Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Suite 4B 1, 110 Irving Street, NW, Washington, DC 20010, USA
    Circulation 108:205-10. 2003
    ..Because CD4+ T lymphocytes are active in regulating humoral and cellular responses of the immune system, we determined whether CD4+ cells contribute to collateral vessel development by using the mouse ischemic hindlimb model...
  57. ncbi Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street W611, Boston, Massachusetts 02118, USA
    J Biol Chem 279:28670-4. 2004
    ..Here, we investigated whether adiponectin regulates angiogenesis in response to tissue ischemia using adiponectin knock-out (KO) mice...
  58. pmc Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion
    Ke Cheng
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Cell Transplant 21:1121-35. 2012
    ..To assess efficacy, 5 × 10(5) iron-labeled, GFP-expressing cells were infused into rat hearts after 45 min ischemia/20 min reperfusion of the left anterior coronary artery, with and without a superimposed magnet...
  59. ncbi Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice. A role for manganese superoxide dismutase
    Jinu Kim
    Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea
    J Biol Chem 281:20349-56. 2006
    Males are much more susceptible to ischemia/reperfusion (I/R)-induced kidney injury when compared with females...
  60. doi Intraoperative skeletal muscle ischemia contributes to risk of renal dysfunction following thoracoabdominal aortic repair
    Charles C Miller
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Eur J Cardiothorac Surg 33:691-4. 2008
    ..We hypothesized that myoglobin nephrotoxicity might arise from leg ischemia caused by femoral artery cannulation, which is required for distal aortic perfusion...
  61. doi Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia
    Satoaki Matoba
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am Heart J 156:1010-8. 2008
    ..marrow mononuclear cells was first attempted in patients with peripheral artery disease (PAD) with critical limb ischemia, and the feasibility was shown by a randomized controlled Therapeutic Angiogenesis by Cell Transplantation (TACT) ..
  62. pmc BRG1 increases transcription of proinflammatory genes in renal ischemia
    Masayo Naito
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Am Soc Nephrol 20:1787-96. 2009
    ..gene-1 (BRG1), a chromatin remodeling enzyme, in the transcription of TNF-alpha and MCP-1 in response to renal ischemia. Two hours after renal ischemic injury in mice, renal TNF-alpha and MCP-1 mRNA increased and remained elevated ..
  63. doi Zero ischemia anatomical partial nephrectomy: a novel approach
    Inderbir S Gill
    Center for Advanced Robotic and Laparoscopic Surgery, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Urol 187:807-14. 2012
    We present a novel concept of zero ischemia anatomical robotic and laparoscopic partial nephrectomy.
  64. ncbi Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning
    Daniel Patschan
    Department of Medicine, New York Medical College BSB, R C21, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 291:F176-85. 2006
    ..The aim of this study was to characterize EPC mobilization and homing in the course of acute renal ischemia. Mice were subjected to unilateral renal artery clamping (UC) for 25 min...
  65. ncbi Angiopoietin-2 impairs revascularization after limb ischemia
    Yvonne Reiss
    Institute of Neurology, Frankfurt University Medical School, 60528 Frankfurt, Germany
    Circ Res 101:88-96. 2007
    ..In conclusion, our studies define Ang-2 as an important molecule for the progression of collateral artery growth and angiogenesis during ischemia and suggest precise Ang-2 dosage activities to accomplish blood vessel growth.
  66. pmc The role of the ubiquitin proteasome system in ischemia and ischemic tolerance
    Robert Meller
    Legacy Clinical Research and Technology Center, Portland, Oregon, USA
    Neuroscientist 15:243-60. 2009
    ..One area of potential for the application of this knowledge is the field of ischemia-induced brain damage, as occurs following a stroke...
  67. doi Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial
    Atsuhiko Kawamoto
    Division of Vascular Regeneration Therapy, Department of Translational Research, Institute of Biomedical Research and Innovation, Kobe 650 0047, Japan
    Stem Cells 27:2857-64. 2009 no-option patients with atherosclerotic peripheral artery disease or Buerger's disease with critical limb ischemia (CLI)...
  68. doi Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model
    Brian D Kubiak
    Department of Surgery, Upstate University Hospital, Syracuse, New York 13210, USA
    Shock 34:525-34. 2010
    ..The clinical implication of this study is that sepsis/trauma can result in an inflammatory ascites that may perpetuate organ injury; removal of the ascites can break the cycle and reduce organ damage...
  69. doi Mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal dysfunction by improving the antioxidant/oxidant balance in the ischemic kidney
    Wenli Zhuo
    Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, PR China
    Urol Int 86:191-6. 2011
    Renal ischemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allograft...
  70. doi Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences
    Brigitte Vollmar
    Institute for Experimental Surgery, University of Rostock, Schillingallee 69a, 18055, Rostock, Germany
    Langenbecks Arch Surg 396:13-29. 2011
    Intestinal ischemia and reperfusion (I/R) is a challenging and life-threatening clinical problem with diverse causes. The delay in diagnosis and treatment contributes to the continued high in-hospital mortality rate.
  71. pmc c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction
    Jianqin Wei
    Department of Molecular and Cellular Pharmacology, Vascular Biology Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:13995-4006. 2011
    Brief periods of ischemia do not damage the heart and can actually protect against reperfusion injury caused by extended ischemia. It is not known what causes the transition from protection to irreversible damage as ischemia progresses...
  72. pmc MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury
    Cecilia Chassin
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    EMBO Mol Med 4:1308-19. 2012
    Intestinal ischemia/reperfusion (I/R) injury causes inflammation and tissue damage and is associated with high morbidity and mortality...
  73. pmc Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice
    Daniel J Ceradini
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    J Biol Chem 283:10930-8. 2008
    Tissue ischemia promotes vasculogenesis through chemokine-induced recruitment of bone marrow-derived endothelial progenitor cells (EPCs). Diabetes significantly impairs this process...
  74. doi ERK1/2 mediates cytoskeleton and focal adhesion impairment in proximal epithelial cells after renal ischemia
    David Sáenz-Morales
    Department of Pathology, Hospital Universitario Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain
    Cell Physiol Biochem 23:285-94. 2009
    ERK1/2 has been reported to be activated in the postischemic kidney but its precise role in ischemia/reperfusion (I/R) injury remains unclear...
  75. pmc High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism
    Federico Biscetti
    Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy
    Diabetes 59:1496-505. 2010
    ..Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes...
  76. pmc Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    Yunwei Wei
    Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
    BMC Gastroenterol 10:42. 2010
    Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure...
  77. pmc Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia
    Ayman Al Haj Zen
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, University of Bristol, Bristol BS28HW, United Kingdom
    Circ Res 107:283-93. 2010
    ..Notch signaling regulates vascular development. However, the implication of the Notch ligand Delta-like 4 (Dll4) in postischemic angiogenesis remains unclear...
  78. doi Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure
    Tamotsu Seki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    J Mol Neurosci 43:30-4. 2011
    ..These findings suggest that PACAP has bimodal effects in the neuroprotection of RGCs against ischemia and that these effects are mediated via different signaling pathways.
  79. pmc Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension
    Eric M George
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Hypertension 57:941-8. 2011
    ..have been implicated in the pathophysiology of hypertension during preeclampsia and in response to placental ischemia in pregnant rats, it is unknown whether chronic induction of HO-1 alters the hypertensive response to placental ..
  80. pmc Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall
    Marisol Chang
    Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
    Shock 37:297-305. 2012
    Intestinal ischemia is associated with high morbidity and mortality, but the underlying mechanisms are uncertain...
  81. ncbi Update on mechanisms of ischemic acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, OH 45229 3039, USA
    J Am Soc Nephrol 17:1503-20. 2006
  82. ncbi Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia
    Yeon Kim
    Department of Physiology, School of Medicine, Pusan National University, Pusan, Korea
    Cell Physiol Biochem 20:867-76. 2007
    ..of MSC derived from bone marrow or adipose tissues has been shown in proangiogenic action in hindlimb ischemia model of nude mice, little information is available regarding comparison of the angiogenic potency between human ..
  83. ncbi Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats
    Makiko Matsumoto
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 14:1825-32. 2003
    ..HIF induction is one possible and attractive explanation for the observed effects...
  84. ncbi The effectiveness of percutaneous transluminal angioplasty for the treatment of critical limb ischemia: a 10-year experience
    Toshifumi Kudo
    Gonda Vascular Center, University of California at Los Angeles, 200 UCLA Medical Plaza, Los Angeles, CA 90095 6958, USA
    J Vasc Surg 41:423-35; discussion 435. 2005
    To determine the efficacy, safety, and long-term results, including continued clinical improvement and limb salvage, of percutaneous transluminal angioplasty (PTA) in patients with critical limb ischemia (CLI).
  85. ncbi Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors
    F Kerendi
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, 550 Peachtree Street, Atlanta, GA 30308, USA
    Basic Res Cardiol 100:404-12. 2005
    ..However, it is not known whether brief ischemia-reperfusion applied to a distant organ at the onset of myocardial reperfusion (i.e...
  86. ncbi The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia
    Stephen M Bauer
    Hospital of University of Pennsylvania, Philadelphia, PA 19124, USA
    J Vasc Surg 43:134-41. 2006
    ..the recruitment of bone marrow-derived endothelial progenitor cells (BMD EPCs) and is stimulated by tissue-level ischemia. We hypothesized that the BMD EPC response is impaired in ischemic wounds and studied the relationship between ..
  87. ncbi Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia
    Michelle Ploughman
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B 3V6
    Eur J Neurosci 25:3453-60. 2007
    ..These findings suggest that exercise facilitates learning of subsequent challenging reaching tasks after stroke, which has the potential to optimize outcomes in patients with stroke...
  88. ncbi Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    Kiyoshi Tsuji
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Stroke 36:1954-9. 2005
    ..Here, we used a combination of pharmacological and genetic approaches to show that tPA promotes MMP-9 levels in stroke in vivo...
  89. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
    ..We investigated efficacy and safety of autologous implantation of bone marrow-mononuclear cells in patients with ischaemic limbs because of peripheral arterial disease...
  90. ncbi Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision
    Annika Spruessel
    Center for Cancer Research, Israelitic Hospital, Hamburg, Germany
    Biotechniques 36:1030-7. 2004
    The aim of this study was to determine the impact of ischemia on gene and protein expression profiles of healthy and malignant colon tissue and, thus, on screening studies for identification of molecular targets and diagnostic molecular ..
  91. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..cell populations and ex vivo expanded endothelial progenitor cells augments neovascularization of tissue after ischemia and contributes to reendothelialization after endothelial injury, thereby, providing a novel therapeutic option...
  92. doi The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush
    T Jehle
    University Eye Hospital Freiburg, Killianstrasse 5, 79106, Freiburg im Breisgau, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1255-63. 2008
    ..The aim of this study was to investigate the effects of NAP on RGC survival after transient retinal ischemia and optic nerve crush.
  93. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
    ..These observations provide a mechanism to account for the severe cell injury that follows hypoxia and reoxygenation when accompanied by NO generation...
  94. doi Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia
    Anne Limbourg
    Junior Research Group Regenerative Agents, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany
    Nat Protoc 4:1737-46. 2009
    ..provide a protocol for the evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Surgical ligation of the femoral artery at a specific site triggers arteriogenesis of small, pre-existing ..
  95. pmc Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    Xiaoxia Z West
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nature 467:972-6. 2010
    ..Taken together, these findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis...
  96. pmc RTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia
    Yi Jin
    Institute of Molecular Medicine, Peking University, Beijing 100871, China
    J Biol Chem 286:22699-705. 2011
    ..VE-Cad/RTEF-1 mice subjected to hindlimb ischemia demonstrated increased levels of HIF-1α, accelerated recovery of blood flow, and increased capillary density ..
  97. pmc Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia
    Galina Dvoriantchikova
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Invest Ophthalmol Vis Sci 53:2823-30. 2012
    To study the role of neuronal nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase-dependent reactive oxygen species (ROS) production in retinal ganglion cell (RGC) death after ischemia.
  98. doi Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers
    Giuseppina Palladini
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Toxicol Pathol 40:722-30. 2012
    Studies assessing the effects of partial-hepatic ischemia/reperfusion (I/R) injury focused on the damage to the ischemic-lobe, whereas few data are available on non-ischemic lobe...
  99. pmc Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia
    Ke Jie Yin
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 287:27055-64. 2012 reduced blood vessel formation and local blood flow perfusion in mouse hindlimbs at 1-3 weeks after hindlimb ischemia. Mechanistically, gain- or loss-of-miR-15a function by lentiviral infection in ECs significantly reduces or ..
  100. doi The effects of PDE5 inhibitory drugs on renal ischemia/reperfusion injury in rats
    A Kucuk
    Department of Physiology, Medical Faculty, Dumlupinar University, Central Campus, Tavsanli Road 10 km, 43270 Kutahya, Turkey
    Mol Biol Rep 39:9775-82. 2012
    ..and Sildenafil, on inducible NOS (iNOS), endothelial NOS (eNOS) and p53 genes expressions and apoptosis in ischemia/reperfusion (I/R) induced oxidative injury in rat renal tissue...
  101. pmc Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension
    Ashley J Bauer
    Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA
    Hypertension 61:1103-10. 2013
    ..The present data indicate that treatment with pravastatin attenuates oxidative stress and lowers MAP in placental ischemia-induced hypertension, but may have negative effects on circulating angiogenic potential during pregnancy...

Research Grants125 found, 100 shown here

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..provided by applicant): Abstract (All changes from the previous submission are marked by line in the margins) Ischemia and reperfusion (I/R) injury results from an acute increase in oxidative/inflammatory stress during reperfusion ..
  2. Yasmin Wadia; Fiscal Year: 2014
    ..of parenchymal hemostasis, pelvi-caliceal reconstruction, parenchymal renorrhaphy, bleeding and prolonged warm ischemia. Laser Tissue Welding, Inc...
  3. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..occlusion or conversely arterial aneurysm formation, manifesting as sudden loss of vision, stroke, myocardial ischemia, aortic arch syndrome, and aneurysm rupture. Once diagnosed, the IVS are considered medical emergencies...
  4. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..Inhibitors of PARP-1 have been investigated pre-clinically and clinically for cardiac ischemia, hemorrhagic shock syndrome, stroke, traumatic CNS injury, diabetes, inflammation, and cancer...
  5. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Therapeutics (RTX) is developing a novel bifunctional small molecule, R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation...
  6. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..whether the effects of aging and estrogen (E2) deficiency are additive with regard to ethanol-induced cardiac ischemia/reperfusion (I/R) injury...
  7. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..are generally accepted to contribute to widespread tissue injury in sepsis via their induction of microvacular ischemia and direct organ toxicity...
  8. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Methods. Experiments will be conducted in anesthetized mice subjected to acute myocardial ischemia-reperfusion induced by reversible coronary ligation, and in cultured cardiomyocytes subjected to oxygen and ..
  9. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..A chronic phase can develop in 6-12 months with vascular endothelial cell damage, ischemia, collagen deposition and decreased bladder compliance...
  10. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  11. Gary Cecchini; Fiscal Year: 2014
    ..response of cells, studies will be undertaken to investigate how acetylation affects the response in a cardiac ischemia/reperfusion injury model...
  12. Norma S Kenyon; Fiscal Year: 2015
    ..subsequent maintenance of or improvement in islet function and to define the effect of aMSC third party MSC on ischemia reperfusion injury. Aim 3...
  13. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..insulin signaling is required for maintaining myocardial viability in the face of hemodynamic stressors such as ischemia and pathological cardiac hypertrophy...
  14. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..In support of this approach, in a rodent model of renal ischemia/reperfusion injury R- 801 profoundly reduced the elevation in BUN and creatinine, blocked neutrophil inflammation,..
  15. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..Developed by the PI and others, broadband oximetry is sensitive to ischemia. It differs from typical near-infrared spectroscopy (NIRS) methods that generally use only 2-4 wavelengths in ..
  16. Kazem M Azadzoi; Fiscal Year: 2016
    ..We attempt to introduce the concept that aging-associated bladder ischemia is an independent factor in the development of non-obstructed non-neurogenic overactive bladder...
  17. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011 a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  18. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..excessive or deficient and both of these have been implicated in bacterial, viral and parasitic infections, ischemia-reperfusion injury, inflammatory bowel disease, celiac disease and colorectal cancer...
  19. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..applicant): ABSTRACT Interruption and subsequent restoration of circulation in tissues causes varying amounts of ischemia- reperfusion injury (IRI)...
  20. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..Recent studies in ischemia, as well as unpublished work from our laboratory, suggest two intriguing approaches for limiting the three major ..
  21. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..Oxidant stress has been implicated in the cellular dysfunction associated with ischemia- reperfusion injury, vascular disease, stroke, diabetes, neurodegenerative diseases, liver disease, renal disease,..
  22. Junichi Sadoshima; Fiscal Year: 2016
    ..we will elucidate the isoform-specific functions of GSK-3 during pressure overload-induced cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on ..
  23. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..DHA-derived mediators, neuroprotectin D1 (NPD1) and aspirin-triggered (AT)-neuroprotectin D1 (AT-NPD1), inhibit ischemia-reperfusion mediated leukocyte infiltration and pro-inflammatory gene expression, as well as elicit ..
  24. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..mitochondrial proteins is a reversible process dependent on oxygen concentration hence the hypoxic environment or ischemia/reperfusion of the preeclamptic placenta may cause protein nitration and altered cellular respiration and ..
  25. Lai Hua Xie; Fiscal Year: 2015
    ..SCD often occurs during acute myocardial ischemia or infarction...
  26. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..The consequent renal ischemia induces oxidative and nitrosative stress, in particular within the nucleus of the renal tubules where DNA single ..
  27. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..applicant): Radikal Therapeutics (RTX) is developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  28. James B Martins; Fiscal Year: 2014
    ..The aim of this project is to continue mechanistic investigation of a canine model of acute myocardial ischemia. This is a remarkably stable model of inducible ventricular tachycardia (VT) and ventricular fibrillation (VF);..
  29. Brian F Volkman; Fiscal Year: 2016
    ..SDF1 is under active investigation as a treatment for prevention of myocardial ischemia/reperfusion injury...
  30. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Ischemia-reperfusion (I/R) injury by way of heart attacks, strokes and diabetes is one of the major causes of morbidity and mortality in the United States...
  31. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..provided by applicant): Different members of the HSP multigene family have been implicated the inhibition of ischemia- induced protein damage, abrogation of protein misfolding/aggregation, and prevention of mitochondrial ..
  32. Michelle A Williams; Fiscal Year: 2014
    ..perinatal disorders - preterm birth, preeclampsia, and intrauterine growth restriction) include uteroplacental ischemia, underperfusion, chronic hypoxia, and infarctions...
  33. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..develops in the surviving myocardium after an acute infarct to counterbalance increased hemodynamic load;and ischemia due to lack of angiogenesis is observed in decompensation of pressure overload hypertrophy, thus subjecting ..
  34. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..of Foxc2 in vivo by RNAi injection with uptake specifically by the proximal tubule will be performed along with Ischemia/Reperfusion (I/R) to simulate the de-differentiation and re-differentiation process...
  35. Iris Z Jaffe; Fiscal Year: 2016
    ..In clinical trials, aldo antagonists significantly decrease cardiovascular mortality and ischemia out of proportion to modest decreases in systemic bp, supporting that a direct vascular effect of aldo ..
  36. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..receptor (ER) expression in the aged heart leads to a vicious cycle of increased oxidative stress (ROS) and ischemia/reperfusion (I/R injury), while selective engagement of non-genomic ER pathways can rescue this phenotype...
  37. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Title of grant: Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Ischemia-reperfusion (I/R) injury to vital organs and tissue can occur in a variety of clinical ..
  38. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..Although the etiology of intestinal cell necrosis is uncertain, risk factors include anisotonic fluids, toxins, ischemia- reperfusion injury and reactive oxygen species...
  39. Jean F Regal; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how placental ischemia during pregnancy leads to maternal hypertension and the only effective cure is early delivery of the placenta...
  40. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..MIs are caused by rupture of coronary atherosclerotic plaques with superimposed coronary thrombosis resulting in ischemia. Patients with MI usually present with signs and symptoms of crushing chest pressure, diaphoresis, malignant ..
  41. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..After cerebral ischemia, expressions of cell cycle proteins are altered...
  42. KATHERINE JULIA KELLY; Fiscal Year: 2014
    ..for increased susceptibility to renal failure with increasing age include the high frequency of diabetes and ischemia. Our preliminary data support the clinically relevant hypothesis that ischemia accelerates the progression of ..
  43. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..Multi-detector computed tomography (CT) will be used to quantify non-invasively myocardial regional perfusion, ischemia, and microvascular integrity, in conjunction with blood oxygen level- dependent magnetic resonance imaging ..
  44. ANN NARDULLI; Fiscal Year: 2014
    ..hormone-induced expression of oxidative stress proteins plays a role in protecting the cerebral cortex from ischemia and identify the individual oxidative stress proteins involved in this neuroprotection, and (4) define the role ..
  45. Claire Larmonier; Fiscal Year: 2014
    ..infiltration in various model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury...
  46. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..the adverse effects of bypass induced by hypothermia, hemolysis, acid-base management, hemodilution and hypoxia-ischemia. After bypass, reperfusion occurs and induces ischemia reperfusion injury...
  47. Gregory L Stahl; Fiscal Year: 2016
    ..reactive oxygen species, which we showed to be responsible for mannose binding lectin (MBL) ligand expression in ischemia/reperfusion (I/R) models...
  48. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    ..oxidative stress, which contributes to the neurodegeneration observed following neurological insults such as ischemia and seizures, as well as contributes to neuronal death in neurodegenerative diseases (Alzheimer's, Parkinson&..
  49. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..principle" experiment in which we will demonstrate that PH is neuroprotective in a mouse model of focal cerebral ischemia/reperfusion...
  50. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..patients but also for extending Laforin study in other stress- induced diseases such as stresses of hypoglycemia, ischemia, and hypoxia...
  51. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    b>Ischemia-reperfusion (IRP) injury is an important clinical problem, which determines morbidity and mortality after liver transplantation, liver surgery and hemorrhagic or septic shock...
  52. Walter J Koch; Fiscal Year: 2016
    ..HF often occurs after myocardial injury or stress such as ischemia or pressure-overload with cardiac hypertrophy occurring first, followed by ventricular remodeling and a loss of ..
  53. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..if the dissection is located in the ascending part of the thoracic aorta since it may lead to global myocardial ischemia by compromising the aortic valve and blood flow through the coronary arteries...
  54. Elizabeth R Jacobs; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Experts in lung transplantation agree that ischemia is a recognized risk factor for all postlung transplant problems...
    Bradford C Berk; Fiscal Year: 2012
    ..migration and tip cell function in the developing retina;and 4) GIT1 is required for angiogenesis in response to ischemia in the retina and hind-limb...
  56. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..encompass those proposed in this Competing Revision include (i) quantitative PCR;(ii) induction of myocardial ischemia (MI) in rats;(iii) adenoviral gene transfer into normal and failing rat hearts in vivo;(iv) cardiac function ..
  57. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Actual renal ischemia is measured in each kidney by estimating with magnetic resonance imaging (MRI), blood (capillary) oxygen (O2) ..
  58. JULIAN G CAMBRONERO; Fiscal Year: 2016
    ..effect) or towards compromised tissues after an ischemic attack (a deleterious effect), such as in the case of ischemia/reperfusion injury (I/RI) in the heart...
  59. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..In Aim 1, we will characterize ATP release in the setting of focal ischemia. Aim 2 intends to define astrocytic Ca2+ signaling in the penumbra, using 2-photon laser scanning microscopy to ..
  60. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..studies should clarify the effect of Epo on atherosclerosis, hypertension, cognitive function, and prevention of ischemia-induced tissue damage...
  61. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    Sponsor Abstract Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased ..
  62. Alexandra M Machikas; Fiscal Year: 2014
    ..b>Ischemia- reperfusion (I/R) injury and associated cell death increases with age;however, the predominant cell death type ..
  63. HUA LINDA CAI; Fiscal Year: 2016
    ..critical signaling role of cardiac microvascular endothelium in mediating cardioprotection during ischemia reperfusion (I/R) injury of the heart...
  64. Prasanna Krishnamurthy; Fiscal Year: 2016
    ..convincing evidence that anti-miR-377 therapy might enhance the EPC engraftment and function in myocardial ischemia leading to efficient myocardial repair...
  65. Conrad Alano; Fiscal Year: 2016
    ..Further, new preliminary data implicates Sirt3 in protection in an in vitro ischemia model...
  66. Hao F Zhang; Fiscal Year: 2015
    ..DR) is a leading cause of irreversible blindness among working-age adults, which is a typical type of ischemia driven retinal disease characterized by microvascular damage to the retina in patients with diabetes...
  67. KEITH W NEHRKE; Fiscal Year: 2016
    ..b>Ischemia-reperfusion injury associated with these conditions can lead to permanent tissue damage or neurologic deficits...
  68. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..also have broad applications to a variety of barrier disruptive diseases including other infectious diseases, cardiac ischemia, asthma, dermatitis, inflammatory bowel diseases, cancer, ciliary diseases, and neurodegenerative disorders.
  69. PETER A FERRAZZANO; Fiscal Year: 2016
    ..My interest in the effect of neurodevelopment on responses to cerebral ischemia is rooted in my clinical experience caring for children with brain injury as a Pediatric Critical Care Physician...
  70. Michelle A Williams; Fiscal Year: 2014
    ..g., systematic inflammation, endothelial dysfunction, oxidative stress, and placental ischemia) have hindered discovery of potential treatment and prevention strategies...
  71. Junichi Sadoshima; Fiscal Year: 2016
    ..results suggest that inhibition of Nox4 is protective during pressure overload but is detrimental during ischemia/reperfusion...
  72. The Role of RAGE in Diabetes and Myocardial Infarction.
    KAREN O'SHEA; Fiscal Year: 2013
    ..necrosis, increased functional recovery and preservation of ATP compared to wild-type littermates 48 hours after ischemia/reperfusion (I/R)...
  73. Rona G Giffard; Fiscal Year: 2016
    ..shown that the heat shock protein 70 kDa (HSP70) family of chaperones or stress proteins, even if expressed after ischemia, can protect the brain...
  74. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..After an initial focal ischemia associated with reduced perfusion of the microvasculature of the optic disc, often in the setting of an ..
  75. Deanna L Kroetz; Fiscal Year: 2014
    ..The renoprotective properties of sEH inhibition will be studied in both a unilateral ureter ligation model and in ischemia/reperfusion...
  76. Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    ..2. To determine an effective dose of Gal-3C to reduce fibrosis in a rat ischemia/reperfusion model of MI. Subaim 2A...
  77. Michael F Romero; Fiscal Year: 2015
    ..channels have been shown to alter cellular contractility and permeability, provide metabolic protection against ischemia and hypoxia, and enhance cellular adaptation to stress in non-ocular tissues...
  78. AZADEH POURSAID; Fiscal Year: 2016
    ..As a complete chemoembolizing system, this polymer will block blood flow inducing ischemia and necrosis of the tumor, locally deliver a chemotherapeutic to kill surrounding tumor, and locally deliver an ..
  79. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013 to investigate the therapeutic potential of transcutaneous vagus nerve stimulation (tVNS) in acute cerebral ischemia. Electrical stimulation of the afferent vagal fibers in the neck has been shown to activate the brainstem vagal ..
  80. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ..Current models describing excitotoxic injury, such as during ischemia and reperfusion (I/R) injury, center on the concept of calcium (Ca2+) ion accumulation leading to cell death...
  81. Paco S Herson; Fiscal Year: 2016
    ..people suffer from cardiac arrest (CA) and receive cardiopulmonary resuscitation (CPR), resulting in hypoxia-ischemia (HI) of the brain and consequently in severe neurological deficits in most of the survivors...
  82. LUIS ALBERTO ORTIZ; Fiscal Year: 2016
    ..Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury in mice...
  83. David S Wilkes; Fiscal Year: 2014
    ..This program project tests the hypothesis that ECM remodeling resulting from rejection, ischemia reperfusion injury or atherosclerosis results in a "pro-inflammatory" matrix due to overexpression of alpha-1 (V) ..
  84. Kenneth A Schenkman; Fiscal Year: 2015
    ..Finally, in Aim 3, spectra will be acquired from the hands of healthy subjects during arm ischemia. These spectra will be used to calibrate in vivo LWR models...
  85. Allison Hubel; Fiscal Year: 2014
    ..stroke, myocardial infarction), diabetes, connective tissue disorders (cartilage defects, osteonecrosis, limb ischemia), chronic obstructive pulmonary disease, nervous system disorders (multiple sclerosis, Parkinson Disease, spinal ..
  86. Gilbert R Kinsey; Fiscal Year: 2014
    ..the previously uncharacterized mechanism of Treg cell-mediated inhibition of the innate immune response in kidney ischemia-reperfusion injury and 2) a new mechanism of renal protection by A2AR agonists by demonstrating a causal link ..
  87. Theodore R Holman; Fiscal Year: 2015
    ..We will utilize these in vitro inhibitors in our transient focal ischemia mouse model and determine if individual inhibitors reduce infarct size, as well as ascertain if our inhibitors ..
  88. Elimelda Moige Ongeri; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Ischemia reperfusion (IR) induced renal injury causes acute renal failure and is associated with high morbidity and mortality rates. The cellular mechanisms underlying IR renal injury are not known...
  89. GLADYS AFOR NGOH; Fiscal Year: 2016
    ..will evaluate whether mitofusins regulate the ability of the vasculature to revascularize following hind limb ischemia (Aim 3)...
  90. Julie Anne Saugstad; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Cerebral ischemia leads to translation arrest, and the inability to recover from this state correlates with neuronal cell death following ischemia/reperfusion injury...
  91. Vineet Gupta; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Infiltration of leukocytes potentiates peritonitis, renal ischemia-reperfusion injury, a major cause of acute renal failure, and other acute inflammatory conditions...
  92. TGF-beta1 and Mitochondrial Dysfunction in LPS-Induced Renal Failure
    L Jay Stallons; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cell injury and death induced by sepsis, ischemia/reperfusion (I/R), drugs, and trauma lead to failure of many organs, including the kidney...
  93. PAMELA ANN TOY-MANNING; Fiscal Year: 2014
    ..spite of many improvements in organ procurement, transplant procedures and immune suppression, the damage done by ischemia-reperfusion injury (IRI) remains problematic, leading to primary graft nonfunctional, delayed graft function and ..
  94. Benjamin A Olenchock; Fiscal Year: 2016
    ..He has found that inhibition of EglN1 protects against cell death after cardiac ischemia- reperfusion injury...
  95. ALEXANDER SOBOLEVSKY; Fiscal Year: 2016
    ..devastating neurological diseases including Alzheimer's disease, amyotrophic lateral sclerosis, epilepsy and ischemia. Regulation of AMPA receptor activity is therefore an important clinical goal...
  96. Peter J Quesenberry; Fiscal Year: 2014
    ..and characterizing MSC-dv carrying "healing" microRNA to renal tissue injured by glycerol exposure or by ischemia/reperfusion or marrow tissue (stem cells) injured by irradiation...
  97. Positive Role of MKP-1 in Angiogenesis.
    JOEL BOERCKEL; Fiscal Year: 2013
    ..These will be evaluated using MKP-1 knockout mouse models of hind limb ischemia, VEGF-induced subcutaneous Matrigel plug angiogenesis, and B16 melanoma tumor growth and angiogenesis...
  98. The distinct roles of AMPK in neurons and astrocytes following stroke
    Jun Li; Fiscal Year: 2013
    ..demonstrated that AMPK is highly expressed in brain and is rapidly activated in energy deprived states such as ischemia. However, the consequences of AMPK activation in stroke may be complex as the two major types of brain cells, ..