Genomes and Genes
Summary: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Publications304 found, 100 shown here
- Profile of diabetic foot complications and its associated complications--a multicentric study from IndiaV Viswanathan
Diabetes Research Centre, Chennai
J Assoc Physicians India 53:933-6. 2005..The prevalence of foot complications such as neuropathy, peripheral vascular disease (PVD), amputations and infections and the associated diabetic complications and practice of foot care among these subjects...
- The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trialWilliam A Marston
University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
Diabetes Care 26:1701-5. 2003To determine if a human fibroblast-derived dermal substitute could promote the healing of diabetic foot ulcers.
- Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healingZhao Jun Liu
The DeWitt Daughtry Family Department of Surgery, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Antioxid Redox Signal 10:1869-82. 2008b>Diabetic foot disease is a major health problem, which affects 15% of the 200 million patients with diabetes worldwide...
- Cellular and molecular basis of wound healing in diabetesHarold Brem
Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
J Clin Invest 117:1219-22. 2007b>Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes...
- Autologous biograft and mesenchymal stem cells in treatment of the diabetic footJan Vojtassak
Institute of Medical Biology and Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Neuro Endocrinol Lett 27:134-7. 2006....
- Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?Stephanie C Wu
Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
Diabetes Care 31:2118-9. 2008Pressure mitigation is crucial for the healing of plantar diabetic foot ulcers. We therefore discuss characteristics and considerations associated with the use of offloading devices.
- Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcersHanna Galkowska
Department of Surgical Research and Transplantology, Medical Reasearch Center, Polish Academy of Sciences, Warsaw, Poland
Wound Repair Regen 14:558-65. 2006..to analyze the expression of various chemotactic and growth factors and their receptors in the margin of diabetic foot ulcers and in normal nondiabetic foot skin...
- Microvascular dysfunction in diabetic foot disease and ulcerationClare Y L Chao
Physiotherapy Department, Queen Elizabeth Hospital, Hong Kong SAR, China
Diabetes Metab Res Rev 25:604-14. 2009b>Diabetic foot disease and ulceration is a major complication that may lead to the amputation of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue breakdown in the diabetic foot...
- Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard methodRonan J Canavan
Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
Diabetes Care 31:459-63. 2008..K. We present here accurate data on trends in diabetes-related (DR) LEAs and non-DRLEAs in the South Tees area over a continuous 5-year period...
- Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)Scot E Dowd
Research and Testing Laboratory, Lubbock, Texas, USA
PLoS ONE 3:e3326. 2008..A primary impediment to the healing of chronic wounds is biofilm phenotype infections. Diabetic foot ulcers are the most common, disabling, and costly complications of diabetes...
- The diabetic foot: from art to science. The 18th Camillo Golgi lectureA J M Boulton
Department of Medicine, Manchester Royal Infirmary, UK
Diabetologia 47:1343-53. 2004b>Diabetic foot ulceration represents a major medical, social and economic problem all over the world. While more than 5% of diabetic patients have a history of foot ulceration, the cumulative lifetime incidence may be as high as 15%...
- Reduction in diabetic amputations over 11 years in a defined U.K. population: benefits of multidisciplinary team work and continuous prospective auditSinghan Krishnan
Ipswich Hospital, Diabetes Center, Heath Road, Ipswich, Suffolk IP4 5PD, UK
Diabetes Care 31:99-101. 2008..To assess changes in diabetic lower-extremity amputation rates in a defined relatively static population over an 11-year period following the introduction of a multidisciplinary foot team...
- Trends in lower extremity amputations in people with and without diabetes in England, 1996-2005Eszter Panna Vamos
Department of Primary Care and Public Health, Imperial College London, UK
Diabetes Res Clin Pract 87:275-82. 2010..To examine trends in non-traumatic lower extremity amputations over a 10-year-period in people with and without diabetes (DM) in England...
- Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008Ana López-de-Andrés
Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain
Diabetes Care 34:1570-6. 2011..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
- Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE StudyL Prompers
Division of Endocrinology, Department of Internal Medicine, University Hospital Maastricht, P Debeyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
Diabetologia 51:747-55. 2008Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD)...
- Split-skin graft in the management of diabetic foot ulcersS M Mahmoud
Soba University Hospital, Khartoum, Sudan
J Wound Care 17:303-6. 2008To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay.
- Wound-healing protocols for diabetic foot and pressure ulcersHarold Brem
Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, NY, USA
Surg Technol Int 11:85-92. 2003b>Diabetic foot and pressure ulcers are chronic wounds by definition. They share similar pathogeneses; i.e., a combination of increased pressure and decreased angiogenic response...
- Age and sex may significantly interact with diabetes on the risks of lower-extremity amputation and peripheral revascularization procedures: evidence from a cohort of a half-million diabetic patientsHua Fen Chen
Department of Public Health, College of Medicine, Fu Jen Catholic University, 510 Chung Cheng Rd, Hsinchuang, Taipei Hsien, 242 Taiwan
Diabetes Care 29:2409-14. 2006....
- Off-loading the diabetic foot wound: a randomized clinical trialD G Armstrong
Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
Diabetes Care 24:1019-22. 2001..To compare the effectiveness of total-contact casts (TCCs), removable cast walkers (RCWs), and half-shoes to heal neuropathic foot ulcerations in individuals with diabetes...
- Genetic and epigenetic events in diabetic wound healingHaloom Rafehi
Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Int Wound J 8:12-21. 2011..Inevitably, this will be accompanied by an increase in the prevalence of diabetic complications, including diabetic foot ulcers...
- Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcersPeter Blume
Affiliated Foot Surgeons, New Haven, Connecticut, USA
Wound Repair Regen 19:302-8. 2011..Both GAM501 and FCG appeared to be safe and well tolerated, and alternate dosing schedules hold promise to improve overall complete wound closure in adequately powered trials...
- Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcersV Krishna Mohan
Bharat Biotech International Limited, Genome Valley, Shameerpet M, Hyderabad 500078, A P, India
Diabetes Res Clin Pract 78:405-11. 2007..coli, has shown enhanced healing of chronic diabetic foot ulcers (DFU) by significantly reducing the duration of healing in addition to providing excellent quality of ..
- A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospitalRavisekhar Gadepalli
Department of Microbiology, All India Institute of Medical Sciences, New Delhi
Diabetes Care 29:1727-32. 2006To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers...
- Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healingH Brem
Department of Surgery, The Mount Sinai Medical Center, New York, NY 10029 6574, USA
Arch Surg 135:627-34. 2000In patients with diabetic foot and pressure ulcers, early intervention with biological therapy will either halt progression or result in rapid healing of these chronic wounds.
- An exercise intervention to improve diabetic patients' gait in a real-life environmentL Allet
Care Services Directorate, Unit of Physiotherapy Research and Quality Assurance, Geneva University Hospital and University of Geneva, 1211 Geneva, Switzerland
Gait Posture 32:185-90. 2010..Gait characteristics and balance are altered in diabetic individuals. Little is known about possible treatment strategies. This study evaluated the effect of a specific training program on diabetic patients' gait...
- Using honey to heal diabetic foot ulcersP C Molan
Honey Research Unit, Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
Adv Skin Wound Care 21:313-6. 2008
- Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidityAntonino Tuttolomondo
Dipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Italy
Cardiovasc Diabetol 9:50. 2010It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention...
- Practical guidelines on the management and prevention of the diabetic foot: based upon the International Consensus on the Diabetic Foot (2007) Prepared by the International Working Group on the Diabetic FootJ Apelqvist
Department of Endocrinology, University Hospital of Malmo, S 205 02 Malmo, Sweden
Diabetes Metab Res Rev 24:S181-7. 2008
- Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trialPeter A Blume
North American Center for Limb Preservation, 506 Blake St, New Haven, CT 06515, USA
Diabetes Care 31:631-6. 2008..The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients...
- Preventive foot care in people with diabetesJ A Mayfield
Bowen Research Center, Department of Family Medicine, Indiana University, Indianapolis 46202, USA
Diabetes Care 21:2161-77. 1998A number of effective, low-cost strategies are available to identify and treat the person at risk for diabetic foot ulcers and lower-extremity amputation...
- Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcersE B Jude
Department of Medicine and Diabetes, Manchester Royal Infirmary and School of Biological Sciences, University of Manchester, Manchester, UK
Diabet Med 19:440-7. 2002..distribution of transforming growth factor-beta (TGF-beta) 1, 2 and 3, and TGF-beta receptor types I and II in diabetic foot ulcers, diabetic skin and normal skin by immunohistochemistry, immunofluorescence and Western blotting...
- Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healingM Muller
Department of Nephrology and Endocrinology, University Hospital, Grenoble, France
Diabet Med 25:419-26. 2008..In diabetic foot ulcers there is an excess of MMPs and a decrease of the tissue inhibitors of MMPs (TIMPs)...
- The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouseJeremy Rich
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Diabetes 54:2904-10. 2005Although Staphylococcus aureus is a major pathogen implicated in diabetic foot infections, little is known about the pathogenesis of this disease. A model of S...
- A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcersAristidis Veves
Joslin Beth Israel Deaconess Foot Center, One Deaconess Rd, Boston, MA 02215, USA
Arch Surg 137:822-7. 2002..Promogran, a wound dressing consisting of collagen and oxidized regenerated cellulose, is more effective that standard care in treating chronic diabetic plantar ulcers...
- A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetesR J Hinchliffe
Department of Vascular Surgery, Nottingham University Hospitals Trust, Nottingham, UK
Diabetes Metab Res Rev 24:S119-44. 2008The outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness...
- Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcersD J Margolis
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Diabetes Care 24:483-8. 2001....
- Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008Eszter P Vamos
Department of Primary Care and Public Health, Imperial College London, London, UK
Diabetes Care 33:2592-7. 2010..To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes and estimate the relative risk of amputations among individuals with diabetes in England...
- Foot complications in Type 2 diabetes: an Australian population-based studyR J Tapp
International Diabetes Institute, Melbourne, Australia
Diabet Med 20:105-13. 2003..To determine the prevalence and risk factors for neuropathy and peripheral vascular disease (PVD) in the Australian diabetic population and identify those at high risk of foot ulceration...
- Preventing foot ulcers in patients with diabetesNalini Singh
Department of Medicine, Division of Endocrinology, Veterans Affairs Puget Sound Healthcare System and University of Washington School of Medicine, Seattle 98108, USA
JAMA 293:217-28. 2005..0% to 4.1%, and the lifetime incidence may be as high as 25%. These ulcers frequently become infected, cause great morbidity, engender considerable financial costs, and are the usual first step to lower extremity amputation...
- Risk stratification systems for diabetic foot ulcers: a systematic reviewM Monteiro-Soares
Serviço de Endocrinologia Pé Diabético, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Unidade 1, Rua Conceição Fernandes, 4434 502, Vila Nova de Gaia, Portugal
Diabetologia 54:1190-9. 2011Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level...
- Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcerMin Woong Sohn
Center forManagement of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois, USA
Diabetes Care 33:98-100. 2010To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers.
- Therapeutic options for diabetic foot infections: a review with an emphasis on tissue penetration characteristicsDavid P Nicolau
Center for Anti Infective Research and Development, Hartford Hospital, Hartford, CT 06102 5037, USA
J Am Podiatr Med Assoc 100:52-63. 2010..These ulcers frequently become infected, and if not treated promptly and appropriately, diabetic foot infections can lead to septic gangrene and amputation...
- A systematic review of interventions to enhance the healing of chronic ulcers of the foot in diabetesF L Game
Foot Ulcer Trials Unit, Nottingham University Hospitals Trust, Nottingham, UK
Diabetes Metab Res Rev 28:119-41. 2012The outcome of management of diabetic foot ulcers is poor, and there is continuing uncertainty concerning optimal approaches to management...
- Successful treatment of diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells and basic fibroblast growth factorJun Asai
Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
J Dermatol 33:349-52. 2006..The patient is able to stand and walk by himself. Topical application of a mixture of PBMC and bFGF appears to be a useful, non-invasive and convenient method for the treatment of diabetic gangrene...
- Importance of time spent standing for those at risk of diabetic foot ulcerationBijan Najafi
Center for Lower Extremity Ambulatory Research CLEAR, Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
Diabetes Care 33:2448-50. 2010..This study aimed to monitor spontaneous daily physical activity in diabetic peripheral neuropathy (DPN) patients and examine both walking and standing activities as important foot-loading conditions...
- Diabetic foot ulcers--a comprehensive reviewP C Leung
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Room 74026, 5th Floor, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
Surgeon 5:219-31. 2007..If limb salvage is the decision, additional means like oxygen therapy, and other alternative medicines, might have benefits. The off-loading of footwear should always be a major consideration as a prevention of ulcer formation...
- 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Clin Infect Dis 54:e132-73. 2012Foot infections are a common and serious problem in persons with diabetes. Diabetic foot infections (DFIs) typically begin in a wound, most often a neuropathic ulceration...
- Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcersAstrid Langer
Institute of Health Economics and Health Care Management, Munich School of Management, Ludwig Maximilians Universitat Munchen, Munich, Germany
BMC Health Serv Res 9:115. 2009..skin substitutes and genetically derived growth factors offer innovative approaches to reduce the burden of diabetic foot and venous leg ulcers for both patients and health care systems. However, they frequently are very costly...
- The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcersMagnus Eneroth
Department of Orthopaedics, Malmo University Hospital, 205 02 Malmo, Sweden
Diabetes Metab Res Rev 24:S76-80. 2008Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments...
- The diabetic foot: a global viewA J Boulton
Manchester Royal Infirmary, Manchester, UK
Diabetes Metab Res Rev 16:S2-5. 2000..that approximately 15% of the more than 150 million people with diabetes world-wide will at some stage develop diabetic foot ulceration...
- Variation in the recorded incidence of amputation of the lower limb in EnglandN Holman
Diabetes Health Intelligence, Yorkshire and Humber Public Health Observatory, York, UK
Diabetologia 55:1919-25. 2012..The study aimed to explore the variation in recorded incidence of lower limb amputation in England...
- Resource utilisation and costs associated with the treatment of diabetic foot ulcers. Prospective data from the Eurodiale StudyL Prompers
Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, Maastricht, The Netherlands
Diabetologia 51:1826-34. 2008The aim of the present study was to investigate resource utilisation and associated costs in patients with diabetic foot ulcers and to analyse differences in resource utilisation between individuals with or without peripheral arterial ..
- A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?Alexandra Alvarsson
Rolf Luft Centre for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Cardiovasc Diabetol 11:18. 2012..Hospital in Solna (KS) following the introduction of consensus guidelines for treatment and prevention of diabetic foot complications, and to identify risk groups of lower extremity amputations that should be targeted for ..
- Platelet-rich plasma: support for its use in wound healingKathleen M Lacci
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8089, USA
Yale J Biol Med 83:1-9. 2010..recombinant human platelet-derived growth factor-BB isomer (rhPDGF-BB) is an efficacious treatment of chronic diabetic foot ulceration...
- Soft tissue reconstruction of the diabetic footGary Peter Jolly
New Britain General Hospital, 100 Grand Street, New Britain, CT 06050, USA
Clin Podiatr Med Surg 20:757-81. 2003Treatment of wounds in the diabetic foot presents a set of difficult problems that requires "out of the box" thinking...
- Expert opinion on the management of infections in the diabetic footB A Lipsky
VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
Diabetes Metab Res Rev 28:163-78. 2012This update of the International Working Group on the Diabetic Foot incorporates some information from a related review of diabetic foot osteomyelitis (DFO) and a systematic review of the management of infection of the diabetic foot...
- Diagnostics and treatment of the diabetic footJan Apelqvist
Department of Endocrinology, University Hospital of Skåne SUS, 205 02, Malmo, Sweden
Endocrine 41:384-97. 2012..Patients with diabetic foot ulcer and decreased perfusion do often not have rest pain or claudication and as a consequence non-invasive ..
- Randomized clinical trial comparing OASIS Wound Matrix to Regranex Gel for diabetic ulcersJeffrey A Niezgoda
Center for Comprehensive Wound Care and Hyperbaric Oxygen Therapy, St Luke s Medical Center, Milwaukee, WI, USA
Adv Skin Wound Care 18:258-66. 2005To compare healing rates at 12 weeks for full-thickness diabetic foot ulcers treated with OASIS Wound Matrix, an acellular wound care product, versus Regranex Gel.
- The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic reviewS A Bus
Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Diabetes Metab Res Rev 24:S162-80. 2008..review was to systematically assess the literature and to determine the available evidence on the use of footwear and offloading interventions for ulcer prevention, ulcer treatment, and plantar pressure reduction in the diabetic foot.
- Wound assessmentJoseph E Grey
Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
BMJ 332:285-8. 2006
- Priorities in offloading the diabetic footSicco A Bus
Academic Medical Centre, Department of Rehabilitation, University of Amsterdam, Amsterdam, The Netherlands
Diabetes Metab Res Rev 28:54-9. 2012Biomechanical factors play an important role in diabetic foot disease. Reducing high foot pressures (i.e. offloading) is one of the main goals in healing and preventing foot ulceration...
- Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal woundsMarcia L Usui
Department of Medicine Dermatology, University of Washington, 1959 NE Pacific Street, Box 356524, Seattle, WA 98195 6524, USA
J Histochem Cytochem 56:687-96. 2008..A better understanding of molecular mechanisms involved in keratinocyte migration may lead to molecular targets for therapies for impaired wound healing...
- New and experimental approaches to treatment of diabetic foot ulcers: a comprehensive review of emerging treatment strategiesR Eldor
Diabetes Research Centre, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel
Diabet Med 21:1161-73. 2004b>Diabetic foot ulcers occur in up to 15% of all diabetic patients and are a leading cause of nontraumatic amputation worldwide...
- The ankle--brachial index and the diabetic foot: a troublesome marriageDimitri Aerden
Diabetic Foot Clinic, Universitair Ziekenhuis Brussel, Brussels, Belgium
Ann Vasc Surg 25:770-7. 2011..The aims of this study were (1) to confirm the notion that the ABI poorly predicts PAD in the diabetic foot, (2) to determine whether arterial calcifications can be blamed, and (3) to establish the role of the ..
- Advanced plastic surgery techniques for soft tissue coverage of the diabetic footThomas Zgonis
Department of Orthopaedics Podiatry Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7776, San Antonio, TX 78229, USA
Clin Podiatr Med Surg 24:547-68, x. 2007Obtaining stable, durable, and functional wound closure of a diabetic foot wound or open pedal amputation through plastic surgical techniques is essential to limit the potential for repeated ulceration, infection, and "supra-pedal" ..
- Knowledge and practice of foot care in people with diabetesR D Pollock
Diabetes Research Group and Life Course and Paediatric Research Group, School of Clinical Medical Sciences, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
Diabetes Res Clin Pract 64:117-22. 2004..To determine knowledge and practice of foot care in people with diabetes...
- Admission trends over 8 years for diabetic foot ulceration in a specialized diabetes unit in cameroonAndre Pascal Kengne
The George Institute for International Health, The University of Sydney, Australia
Int J Low Extrem Wounds 8:180-6. 2009..With one exception, the amputation rate of 16% (95% CI = 11%-20%) was similar across years. Foot ulcer is a major cause of hospital admission and bed use for diabetes in Cameroon...
- Patient and professional perspectives on prescribed therapeutic footwear for people with diabetes: a vignette studyMaxine Johnson
School of Health and Related Research, University of Sheffield, Sheffield, UK
Patient Educ Couns 64:167-72. 2006..This article draws on a qualitative study to identify and discuss patient and health professional views of the use of therapeutic footwear for people with diabetes-related foot complications...
- Challenges for management of the diabetic foot in Africa: doing more with lessZulfiqarali G Abbas
Department of Internal Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
Int Wound J 4:305-13. 2007..Gangrene and infections are two of the more serious sequelae of diabetic foot ulcer disease that cause long-standing disability, loss of income, amputation or death...
- Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcersAaron G Paul
Department of Orthopaedic Surgery, Sarawak General Hospital, Sarawak, Malaysia
Int Wound J 6:39-46. 2009..therapy (MDT) with the sterile larvae of Lucilia cuprina (a tropical blowfly maggot) for the treatment of diabetic foot ulcers. Literature thus far has only reported results with the temperate maggot, Lucilia sericata...
- Developing and validating a risk score for lower-extremity amputation in patients hospitalized for a diabetic foot infectionBenjamin A Lipsky
Department of Medicine, University of Washington, Seattle, WA, USA
Diabetes Care 34:1695-700. 2011b>Diabetic foot infection is the predominant predisposing factor to nontraumatic lower-extremity amputation (LEA), but few studies have investigated which specific risk factors are most associated with LEA...
- Depression and incident diabetic foot ulcers: a prospective cohort studyLISA H WILLIAMS
Department of Medicine, Division of Dermatology, University of Washington, Seattle, Wash, USA
Am J Med 123:748-754.e3. 2010To test whether depression is associated with an increased risk of incident diabetic foot ulcers.
- Role of magnetic resonance imaging in the evaluation of diabetic foot with suspected osteomyelitisU Rozzanigo
Diagnostic Imaging Unit, Carlo Poma Hospital, Viale Albertoni 1, 46100, Mantua, Italy
Radiol Med 114:121-32. 2009This study evaluated Magnetic Resonance Imaging (MRI) in infected diabetic foot ulcers.
- Influence of bioengineered skin substitutes on diabetic foot ulcer and venous leg ulcer outcomesC Barber
ASERNIP S, Royal Australasian College of Surgeons, Stepney, Australia
J Wound Care 17:517-27. 2008..systematic review indicates that bioengineered skin substitutes with a dermal component may improve healing outcomes in diabetic foot ulcers and venous leg ulcers. However, better designed trials with longer follow-up periods are needed.
- Diabetes foot self-care practices in the German populationSascha Schmidt
Hessian Institute of Nursing Research Frankfurt Main, University of Applied Sciences, Frankfurt am Main, Germany
J Clin Nurs 17:2920-6. 2008The object of this study was to find out which self-care activities patients with diabetes perform to prevent diabetic foot syndrome (DFS) and to look for differences between patient groups (diabetes education and foot at risk).
- Can the use of a topical antifungal nail lacquer reduce risk for diabetic foot ulceration? Results from a randomised controlled pilot studyDavid G Armstrong
Scholl s Center for Lower Extremity Ambulatory Research CLEAR at Rosalind Franklin University of Medicine, 3333 Green Bay Road, Chicago, IL 60064, USA
Int Wound J 2:166-70. 2005..In this randomised controlled trial, 70 persons at high risk for diabetic foot ulceration were enrolled into a preventative care program involving daily self-inspection with the possible ..
- Diabetic foot ulcers and infections: current conceptsJason H Calhoun
Department of Orthopaedics and Rehabilitation, University of Texas Medical Branch, Galveston, USA
Adv Skin Wound Care 15:31-42; quiz 44-5. 2002
- Angiosomes and wound care in the diabetic footMark W Clemens
Department of Plastic Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
Foot Ankle Clin 15:439-64. 2010..This article focuses on the surgical implications of angiosomes of the foot and ankle and their arterial-arterial connections...
- Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab culturesEric Senneville
Diabetic Foot Clinic, Dron Hospital, Tourcoing, France
Clin Infect Dis 42:57-62. 2006We assessed the diagnostic value of swab cultures by comparing them with corresponding cultures of percutaneous bone biopsy specimens for patients with diabetic foot osteomyelitis.
- Treatment of diabetic foot infection with hyperbaric oxygen therapyChin En Chen
Department of Orthopedic Surgery, Golden Hospital, 12 2, Minsheng E Rd, Pingtung City 900, Taiwan, ROC
Foot Ankle Surg 16:91-5. 2010This study was performed to evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of the infected diabetic foot.
- Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan creamBenjamin A Lipsky
Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98116 1597, USA
Clin Infect Dis 47:1537-45. 2008Topical antimicrobial therapy of infected diabetic foot ulcers can focus on the wound and avoid the adverse effects of systemic anti-infective agents...
- Predictive model of short-term amputation during hospitalization of patients due to acute diabetic foot infectionsJosé Barberán
Infectious Diseases Department, Hospital Central de la Defensa Gomez Ulla, Madrid, Spain
Enferm Infecc Microbiol Clin 28:680-4. 2010Factors predicting short-term amputation during hospital treatment of patients admitted for acute diabetic foot infections are of interest for clinicians managing the acute episode.
- Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcerElizabeth Bosede Bolajoko
Department of Chemical Pathology, University of Limpopo, Medunsa Campus, Garankuwa
S Afr Med J 98:614-7. 2008Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer...
- Negative-pressure wound therapy and diabetic foot amputations: a retrospective study of payer claims dataRobert G Frykberg
Podiatry Section, Carl T Hayden Veterans Administration Medical Center, Phoenix, AZ 85012, USA
J Am Podiatr Med Assoc 97:351-9. 2007This study was undertaken to assess the benefits of negative-pressure wound therapy (NPWT) versus traditional wound therapies in reducing the incidence of lower-extremity amputations in patients with diabetic foot ulcers.
- [Diabetic foot and risk factors]V Martín Borge
Unidad de Diabetes, Hospital Universitario La Paz, Madrid
An Med Interna 24:263-6. 2007To identify clinic and metabolic risk factors for diabetic neuropathy and peripheral arterial disease in patients evaluated in a diabetic foot unit care.
- Prevalence of risk factors for diabetic foot complicationsFatma Al-Maskari
Department of Community Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, PO Box 17666, UAE
BMC Fam Pract 8:59. 2007..The aim of this study was to determine the prevalence and risk factors for foot complications among diabetic patients in Al-Ain district, United Arab Emirates (UAE)...
- Assessment and treatment of diabetic foot ulcerA Shojaie Fard
Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Int J Clin Pract 61:1931-8. 2007..A critical triad of neuropathy, minor foot trauma and foot deformity was found in > 63% of diabetic foot ulcers (DFU). Peripheral vascular disease (PVD) has been identified in 30% of foot ulcers...
- Diabetes and bone: advantages and limitations of radiological, radionuclide and hybrid techniques in the assessment of diabetic footG Gnanasegaran
Department of Nuclear Medicine, Guys and St Thomas Hospital NHS Foundation Trust Hospital, London, UK
Minerva Endocrinol 34:237-54. 2009..In this review we discuss the efficacy of radiological and radionuclide techniques in the assessment of diabetic foot infection.
- Outcome of diabetic foot osteomyelitis treated nonsurgically: a retrospective cohort studyEric Senneville
Diabetic Foot Clinic, Dron Hospital, Tourcoing, France
Diabetes Care 31:637-42. 2008The purpose of this article was to identify criteria predictive of remission in nonsurgical treatment of diabetic foot osteomyelitis.
- Multi-plug insole design to reduce peak plantar pressure on the diabetic foot during walkingRicardo L Actis
Engineering Software Research and Development, Inc, 111 West Port Plaza, Suite 825, St Louis, MO 63146, USA
Med Biol Eng Comput 46:363-71. 2008....
- Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencingScot E Dowd
United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
BMC Microbiol 8:43. 2008..gradient gel electrophoresis were utilized to survey the major populations of bacteria that occur in the pathogenic biofilms of three types of chronic wound types: diabetic foot ulcers (D), venous leg ulcers (V), and pressure ulcers (P).
- Psychosocial and behavioral aspects of diabetic foot lesionsLoretta Vileikyte
Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
Curr Diab Rep 8:119-25. 2008This article reviews key findings from recently conducted and ongoing studies into how patients adapt to diabetic foot complications by focusing on two areas...
- The treatment of diabetic foot infections: focus on ertapenemMichael Edmonds
Diabetic Foot Clinic, King s College Hospital, Denmark Hill, London, UK
Vasc Health Risk Manag 5:949-63. 2009Clinically, 3 distinct stages of diabetic foot infection may be recognized: localized infection, spreading infection and severe infection. Each of these presentations may be complicated by osteomyelitis...
- Epidermal growth factor intralesional infiltrations can prevent amputation in patients with advanced diabetic foot woundsJorge Berlanga Acosta
Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Havana City, Cuba
Int Wound J 3:232-9. 2006..5 +/- 4.9 days. Wound recurrence after 1 year of follow-up appeared in only one patient. Preliminary evidences suggest that EGF intralesional infiltrations may be effective in reducing diabetic lower limb amputation...
- Diabetic foot infection: usefulness of SPECT/CT for 99mTc-HMPAO-labeled leukocyte imagingLuca Filippi
Section of Nuclear Medicine, Ospedale Maggiore, Trieste, Italy
J Nucl Med 50:1042-6. 2009Our aim was to evaluate the role of SPECT/CT for the diagnosis of diabetic foot infection by labeled leukocytes.
- Clinical profile and management outcome of diabetic foot ulcers in a tertiary care hospitalKhalid Mehmood
Department of Medicine, Down University of Health Sciences and Civil Hospital, Karachi
J Coll Physicians Surg Pak 18:408-12. 2008To determine major risk factors and management outcome of diabetic foot ulcers in order to prevent amputation.
- The diabetic foot: perspectives from Chennai, South IndiaVijay Viswanathan
M V Hospital for Diabetes and Diabetes Research Centre, Royapuram, Chennai, India
Int J Low Extrem Wounds 6:34-6. 2007..Prompt and aggressive treatment of diabetic foot ulcers can often prevent exacerbation of the problem and eliminate the potential for amputation...
- Diabetic foot infections: A need for innovative assessmentsTimothy K Fisher
University of Arizona, Tucson, 85724, USA
Int J Low Extrem Wounds 9:31-6. 2010..Adopting these advances in diagnosis and treatment may help with overall prognosis and reduce health care costs...
- Selective primary angioplasty following an angiosome model of reperfusion in the treatment of Wagner 1-4 diabetic foot lesions: practice in a multidisciplinary diabetic limb serviceVlad Adrian Alexandrescu
Department of Surgery, Princesse Paola Hospital, Marche en Famenne, Belgium
J Endovasc Ther 15:580-93. 2008....
- Patients' perspectives on foot complications in type 2 diabetes: a qualitative studyLone Gale
Department of Social Medicine, University of Bristol, Horfield Health Centre, Bristol
Br J Gen Pract 58:555-63. 2008..Foot ulceration is a major health problem for people with diabetes. To minimise the risk of ulceration, patients are advised to perform preventive foot self-care...
- Facility-level variations in patient-reported footcare knowledge sufficiency: implications for diabetes performance measurementMangala Rajan
Center for Healthcare Knowledge Management, Department of Veteran Affairs New Jersey Health Care System, East Orange, NJ, United States
Prim Care Diabetes 1:147-53. 2007..To evaluate medical center variation in self-reported knowledge of footcare practices by veterans at high risk for lower extremity complications...
- Wound EMR to Decrease Limb Amputations in Persons with DiabetesHarold Brem; Fiscal Year: 2010..Wound Electronic Medical Record (OWEMR) as a clinical intervention tool reduces amputations resulting from diabetic foot ulcers (DFUs) in a variety of healthcare settings...
- FDG-PET Imaging in Complicated Diabetic FootAbass Alavi; Fiscal Year: 2005..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
- Growth factor delivery patch for wound healingFen Zhang; Fiscal Year: 2005..5 million Americans annually, particularly the elderly. Diseases within this family include diabetic foot ulcers, venous stasis ulcers, and pressure ulcers...
- Evaluation of a novel connexin-based peptide for the treatment of diabetic woundsGautam Ghatnekar; Fiscal Year: 2007..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, ..
- Role of Neuropeptides in Diabetic Foot ProblemsARISTIDIS contact VEVES; Fiscal Year: 2010Impaired wound healing is an important clinical problem in diabetes resulting in failure to completely heal diabetic foot ulcers and more that 75,000 lower extremity amputations annually...
- Diabetic Foot and Pressure Ulcer DatabankHarold Brem; Fiscal Year: 2007..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
- Diabetic Foot and Pressure Ulcer DatabankHarold Brem; Fiscal Year: 2009..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
- Emotional Stress and Wound Healing in DiabetesAndrew Boulton; Fiscal Year: 2007b>Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
- The Development and Testing of a Sonic Treatment Brush for Diabetic Foot UlcersROBERT AKRIDGE; Fiscal Year: 2007Non-healing diabetic foot ulcers are potentially a limb- and life-threatening complication of chronic diabetes mellitus and associated peripheral neuropathy...
- Emotional Stress and Wound Healing in DiabetesLoretta Vileikyte; Fiscal Year: 2009b>Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
- Emotional Stress and Wound Healing in DiabetesLoretta Vileikyte; Fiscal Year: 2010b>Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
- Clinical Testing of Hyperspectral Assessment & Prediction of Diabetic Foot UlcersKEVIN SCHOMACKER; Fiscal Year: 2007..We believe FHSI can have positive impact on quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs. ..
- Topical Salicylanilides to Treat Diabetic Foot UlcerJoseph Dunn; Fiscal Year: 2002..class of patented, Lipophilic, Antimicrobial, Anti-inflammatory Drugs (LAADs) for the treatment of Diabetic Foot Ulcer (DFU)...
- Skin Interface Friction TransducerJEFFREY SCHOESS; Fiscal Year: 2003..is 15 to 46 times higher in diabetics than persons without diabetic mellitus, with the vast majority of diabetic foot complications resulting in amputation due to formation of skin ulcers...
- Diabetic Foot Ulcer Healing by Load Relieving DressingsJoseph Loomis; Fiscal Year: 2006..abstract_text> ..
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2003..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
- Discovery of a Platelet Derived Growth Factor Peptide-based MimeticPaul Hamilton; Fiscal Year: 2006Project Summary/Abstract: Diabetic foot ulcers are a significant health problem that imposes high costs on both patients and society (Boulton, Vileikyte et al. 2005)...
- INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDSSufan Chien; Fiscal Year: 2007..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
- INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDSSufan Chien; Fiscal Year: 2009..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
- INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDSSufan Chien; Fiscal Year: 2010..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
- INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDSSufan Chien; Fiscal Year: 2010
- BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALINGCharles Saltzman; Fiscal Year: 2003..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
- Local Angiogenic Gene Therapy/VEGF/Treat Diabetic UlcersHarold Brem; Fiscal Year: 2003..The estimated annual cost of $9 billion doesn't include the pam, suffering, and morbidity of diabetic foot ulcers...
- Impaired Wound Healing in Diabetic Foot UlcerationAristidis Veves; Fiscal Year: 2007b>Diabetic foot ulceration (DFU) is a major problem that significantly impairs the quality of life of the patient, leads to prolonged hospitalization and may require a major amputation...
- TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERSJames Varani; Fiscal Year: 2003..In the majority of diabetic subjects, the underlying factor which contributes to eventual amputation is the diabetic foot ulcer...
- Healing Chronic Wounds by Controlling Microbial BiofilmPhilip Stewart; Fiscal Year: 2007..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..
- PROMOTION OF WOUND VASCULARIZATION AND CLOSURERonald Hill; Fiscal Year: 2005Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27...
- PHARMACOLOGIC PROMOTION OF WOUND HEALINGBruce Cronstein; Fiscal Year: 2007..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
- Healing Chronic Wounds by Controlling Microbial BiofilmPhilip Stewart; Fiscal Year: 2007..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..