diabetic foot

Summary

Summary: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

Top Publications

  1. ncbi Profile of diabetic foot complications and its associated complications--a multicentric study from India
    V Viswanathan
    Diabetes Research Centre, Chennai
    J Assoc Physicians India 53:933-6. 2005
  2. ncbi The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial
    William A Marston
    University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
    Diabetes Care 26:1701-5. 2003
  3. pmc Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing
    Zhao Jun Liu
    The DeWitt Daughtry Family Department of Surgery, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Antioxid Redox Signal 10:1869-82. 2008
  4. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
  5. ncbi Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot
    Jan Vojtassak
    Institute of Medical Biology and Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Neuro Endocrinol Lett 27:134-7. 2006
  6. pmc Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?
    Stephanie C Wu
    Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 31:2118-9. 2008
  7. ncbi Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers
    Hanna Galkowska
    Department of Surgical Research and Transplantology, Medical Reasearch Center, Polish Academy of Sciences, Warsaw, Poland
    Wound Repair Regen 14:558-65. 2006
  8. doi Microvascular dysfunction in diabetic foot disease and ulceration
    Clare Y L Chao
    Physiotherapy Department, Queen Elizabeth Hospital, Hong Kong SAR, China
    Diabetes Metab Res Rev 25:604-14. 2009
  9. ncbi Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method
    Ronan J Canavan
    Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
    Diabetes Care 31:459-63. 2008
  10. pmc Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    Research and Testing Laboratory, Lubbock, Texas, USA
    PLoS ONE 3:e3326. 2008

Detail Information

Publications304 found, 100 shown here

  1. ncbi Profile of diabetic foot complications and its associated complications--a multicentric study from India
    V Viswanathan
    Diabetes Research Centre, Chennai
    J Assoc Physicians India 53:933-6. 2005
    ..The prevalence of foot complications such as neuropathy, peripheral vascular disease (PVD), amputations and infections and the associated diabetic complications and practice of foot care among these subjects...
  2. ncbi The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial
    William A Marston
    University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
    Diabetes Care 26:1701-5. 2003
    To determine if a human fibroblast-derived dermal substitute could promote the healing of diabetic foot ulcers.
  3. pmc Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing
    Zhao Jun Liu
    The DeWitt Daughtry Family Department of Surgery, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Antioxid Redox Signal 10:1869-82. 2008
    b>Diabetic foot disease is a major health problem, which affects 15% of the 200 million patients with diabetes worldwide...
  4. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
    b>Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes...
  5. ncbi Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot
    Jan Vojtassak
    Institute of Medical Biology and Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Neuro Endocrinol Lett 27:134-7. 2006
    ....
  6. pmc Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?
    Stephanie C Wu
    Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 31:2118-9. 2008
    Pressure mitigation is crucial for the healing of plantar diabetic foot ulcers. We therefore discuss characteristics and considerations associated with the use of offloading devices.
  7. ncbi Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers
    Hanna Galkowska
    Department of Surgical Research and Transplantology, Medical Reasearch Center, Polish Academy of Sciences, Warsaw, Poland
    Wound Repair Regen 14:558-65. 2006
    ..to analyze the expression of various chemotactic and growth factors and their receptors in the margin of diabetic foot ulcers and in normal nondiabetic foot skin...
  8. doi Microvascular dysfunction in diabetic foot disease and ulceration
    Clare Y L Chao
    Physiotherapy Department, Queen Elizabeth Hospital, Hong Kong SAR, China
    Diabetes Metab Res Rev 25:604-14. 2009
    b>Diabetic foot disease and ulceration is a major complication that may lead to the amputation of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue breakdown in the diabetic foot...
  9. ncbi Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method
    Ronan J Canavan
    Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
    Diabetes Care 31:459-63. 2008
    ..K. We present here accurate data on trends in diabetes-related (DR) LEAs and non-DRLEAs in the South Tees area over a continuous 5-year period...
  10. pmc Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    Research and Testing Laboratory, Lubbock, Texas, USA
    PLoS ONE 3:e3326. 2008
    ..A primary impediment to the healing of chronic wounds is biofilm phenotype infections. Diabetic foot ulcers are the most common, disabling, and costly complications of diabetes...
  11. ncbi The diabetic foot: from art to science. The 18th Camillo Golgi lecture
    A J M Boulton
    Department of Medicine, Manchester Royal Infirmary, UK
    Diabetologia 47:1343-53. 2004
    b>Diabetic foot ulceration represents a major medical, social and economic problem all over the world. While more than 5% of diabetic patients have a history of foot ulceration, the cumulative lifetime incidence may be as high as 15%...
  12. ncbi Reduction in diabetic amputations over 11 years in a defined U.K. population: benefits of multidisciplinary team work and continuous prospective audit
    Singhan Krishnan
    Ipswich Hospital, Diabetes Center, Heath Road, Ipswich, Suffolk IP4 5PD, UK
    Diabetes Care 31:99-101. 2008
    ..To assess changes in diabetic lower-extremity amputation rates in a defined relatively static population over an 11-year period following the introduction of a multidisciplinary foot team...
  13. doi Trends in lower extremity amputations in people with and without diabetes in England, 1996-2005
    Eszter Panna Vamos
    Department of Primary Care and Public Health, Imperial College London, UK
    Diabetes Res Clin Pract 87:275-82. 2010
    ..To examine trends in non-traumatic lower extremity amputations over a 10-year-period in people with and without diabetes (DM) in England...
  14. pmc Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008
    Ana López-de-Andrés
    Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain
    Diabetes Care 34:1570-6. 2011
    ..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
  15. pmc Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study
    L Prompers
    Division of Endocrinology, Department of Internal Medicine, University Hospital Maastricht, P Debeyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 51:747-55. 2008
    Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD)...
  16. ncbi Split-skin graft in the management of diabetic foot ulcers
    S M Mahmoud
    Soba University Hospital, Khartoum, Sudan
    J Wound Care 17:303-6. 2008
    To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay.
  17. ncbi Wound-healing protocols for diabetic foot and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:85-92. 2003
    b>Diabetic foot and pressure ulcers are chronic wounds by definition. They share similar pathogeneses; i.e., a combination of increased pressure and decreased angiogenic response...
  18. ncbi Age and sex may significantly interact with diabetes on the risks of lower-extremity amputation and peripheral revascularization procedures: evidence from a cohort of a half-million diabetic patients
    Hua Fen Chen
    Department of Public Health, College of Medicine, Fu Jen Catholic University, 510 Chung Cheng Rd, Hsinchuang, Taipei Hsien, 242 Taiwan
    Diabetes Care 29:2409-14. 2006
    ....
  19. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
    ..To compare the effectiveness of total-contact casts (TCCs), removable cast walkers (RCWs), and half-shoes to heal neuropathic foot ulcerations in individuals with diabetes...
  20. doi Genetic and epigenetic events in diabetic wound healing
    Haloom Rafehi
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Int Wound J 8:12-21. 2011
    ..Inevitably, this will be accompanied by an increase in the prevalence of diabetic complications, including diabetic foot ulcers...
  21. pmc Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers
    Peter Blume
    Affiliated Foot Surgeons, New Haven, Connecticut, USA
    Wound Repair Regen 19:302-8. 2011
    ..Both GAM501 and FCG appeared to be safe and well tolerated, and alternate dosing schedules hold promise to improve overall complete wound closure in adequately powered trials...
  22. ncbi Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcers
    V Krishna Mohan
    Bharat Biotech International Limited, Genome Valley, Shameerpet M, Hyderabad 500078, A P, India
    Diabetes Res Clin Pract 78:405-11. 2007
    ..coli, has shown enhanced healing of chronic diabetic foot ulcers (DFU) by significantly reducing the duration of healing in addition to providing excellent quality of ..
  23. ncbi A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital
    Ravisekhar Gadepalli
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi
    Diabetes Care 29:1727-32. 2006
    To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers...
  24. ncbi Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing
    H Brem
    Department of Surgery, The Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Arch Surg 135:627-34. 2000
    In patients with diabetic foot and pressure ulcers, early intervention with biological therapy will either halt progression or result in rapid healing of these chronic wounds.
  25. doi An exercise intervention to improve diabetic patients' gait in a real-life environment
    L Allet
    Care Services Directorate, Unit of Physiotherapy Research and Quality Assurance, Geneva University Hospital and University of Geneva, 1211 Geneva, Switzerland
    Gait Posture 32:185-90. 2010
    ..Gait characteristics and balance are altered in diabetic individuals. Little is known about possible treatment strategies. This study evaluated the effect of a specific training program on diabetic patients' gait...
  26. doi Using honey to heal diabetic foot ulcers
    P C Molan
    Honey Research Unit, Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
    Adv Skin Wound Care 21:313-6. 2008
  27. pmc Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Italy
    Cardiovasc Diabetol 9:50. 2010
    It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention...
  28. doi Practical guidelines on the management and prevention of the diabetic foot: based upon the International Consensus on the Diabetic Foot (2007) Prepared by the International Working Group on the Diabetic Foot
    J Apelqvist
    Department of Endocrinology, University Hospital of Malmo, S 205 02 Malmo, Sweden
    Diabetes Metab Res Rev 24:S181-7. 2008
  29. ncbi Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial
    Peter A Blume
    North American Center for Limb Preservation, 506 Blake St, New Haven, CT 06515, USA
    Diabetes Care 31:631-6. 2008
    ..The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients...
  30. ncbi Preventive foot care in people with diabetes
    J A Mayfield
    Bowen Research Center, Department of Family Medicine, Indiana University, Indianapolis 46202, USA
    Diabetes Care 21:2161-77. 1998
    A number of effective, low-cost strategies are available to identify and treat the person at risk for diabetic foot ulcers and lower-extremity amputation...
  31. ncbi Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers
    E B Jude
    Department of Medicine and Diabetes, Manchester Royal Infirmary and School of Biological Sciences, University of Manchester, Manchester, UK
    Diabet Med 19:440-7. 2002
    ..distribution of transforming growth factor-beta (TGF-beta) 1, 2 and 3, and TGF-beta receptor types I and II in diabetic foot ulcers, diabetic skin and normal skin by immunohistochemistry, immunofluorescence and Western blotting...
  32. pmc Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
    M Muller
    Department of Nephrology and Endocrinology, University Hospital, Grenoble, France
    Diabet Med 25:419-26. 2008
    ..In diabetic foot ulcers there is an excess of MMPs and a decrease of the tissue inhibitors of MMPs (TIMPs)...
  33. ncbi The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse
    Jeremy Rich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Diabetes 54:2904-10. 2005
    Although Staphylococcus aureus is a major pathogen implicated in diabetic foot infections, little is known about the pathogenesis of this disease. A model of S...
  34. ncbi A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers
    Aristidis Veves
    Joslin Beth Israel Deaconess Foot Center, One Deaconess Rd, Boston, MA 02215, USA
    Arch Surg 137:822-7. 2002
    ..Promogran, a wound dressing consisting of collagen and oxidized regenerated cellulose, is more effective that standard care in treating chronic diabetic plantar ulcers...
  35. ncbi A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes
    R J Hinchliffe
    Department of Vascular Surgery, Nottingham University Hospitals Trust, Nottingham, UK
    Diabetes Metab Res Rev 24:S119-44. 2008
    The outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness...
  36. ncbi Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers
    D J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Diabetes Care 24:483-8. 2001
    ....
  37. pmc Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008
    Eszter P Vamos
    Department of Primary Care and Public Health, Imperial College London, London, UK
    Diabetes Care 33:2592-7. 2010
    ..To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes and estimate the relative risk of amputations among individuals with diabetes in England...
  38. ncbi Foot complications in Type 2 diabetes: an Australian population-based study
    R J Tapp
    International Diabetes Institute, Melbourne, Australia
    Diabet Med 20:105-13. 2003
    ..To determine the prevalence and risk factors for neuropathy and peripheral vascular disease (PVD) in the Australian diabetic population and identify those at high risk of foot ulceration...
  39. ncbi Preventing foot ulcers in patients with diabetes
    Nalini Singh
    Department of Medicine, Division of Endocrinology, Veterans Affairs Puget Sound Healthcare System and University of Washington School of Medicine, Seattle 98108, USA
    JAMA 293:217-28. 2005
    ..0% to 4.1%, and the lifetime incidence may be as high as 25%. These ulcers frequently become infected, cause great morbidity, engender considerable financial costs, and are the usual first step to lower extremity amputation...
  40. doi Risk stratification systems for diabetic foot ulcers: a systematic review
    M Monteiro-Soares
    Serviço de Endocrinologia Pé Diabético, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Unidade 1, Rua Conceição Fernandes, 4434 502, Vila Nova de Gaia, Portugal
    Diabetologia 54:1190-9. 2011
    Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level...
  41. pmc Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer
    Min Woong Sohn
    Center forManagement of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois, USA
    Diabetes Care 33:98-100. 2010
    To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers.
  42. ncbi Therapeutic options for diabetic foot infections: a review with an emphasis on tissue penetration characteristics
    David P Nicolau
    Center for Anti Infective Research and Development, Hartford Hospital, Hartford, CT 06102 5037, USA
    J Am Podiatr Med Assoc 100:52-63. 2010
    ..These ulcers frequently become infected, and if not treated promptly and appropriately, diabetic foot infections can lead to septic gangrene and amputation...
  43. ncbi A systematic review of interventions to enhance the healing of chronic ulcers of the foot in diabetes
    F L Game
    Foot Ulcer Trials Unit, Nottingham University Hospitals Trust, Nottingham, UK
    Diabetes Metab Res Rev 28:119-41. 2012
    The outcome of management of diabetic foot ulcers is poor, and there is continuing uncertainty concerning optimal approaches to management...
  44. ncbi Successful treatment of diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells and basic fibroblast growth factor
    Jun Asai
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
    J Dermatol 33:349-52. 2006
    ..The patient is able to stand and walk by himself. Topical application of a mixture of PBMC and bFGF appears to be a useful, non-invasive and convenient method for the treatment of diabetic gangrene...
  45. pmc Importance of time spent standing for those at risk of diabetic foot ulceration
    Bijan Najafi
    Center for Lower Extremity Ambulatory Research CLEAR, Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 33:2448-50. 2010
    ..This study aimed to monitor spontaneous daily physical activity in diabetic peripheral neuropathy (DPN) patients and examine both walking and standing activities as important foot-loading conditions...
  46. ncbi Diabetic foot ulcers--a comprehensive review
    P C Leung
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Room 74026, 5th Floor, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
    Surgeon 5:219-31. 2007
    ..If limb salvage is the decision, additional means like oxygen therapy, and other alternative medicines, might have benefits. The off-loading of footwear should always be a major consideration as a prevention of ulcer formation...
  47. doi 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections
    Benjamin A Lipsky
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Clin Infect Dis 54:e132-73. 2012
    Foot infections are a common and serious problem in persons with diabetes. Diabetic foot infections (DFIs) typically begin in a wound, most often a neuropathic ulceration...
  48. pmc Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers
    Astrid Langer
    Institute of Health Economics and Health Care Management, Munich School of Management, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Health Serv Res 9:115. 2009
    ..skin substitutes and genetically derived growth factors offer innovative approaches to reduce the burden of diabetic foot and venous leg ulcers for both patients and health care systems. However, they frequently are very costly...
  49. ncbi The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcers
    Magnus Eneroth
    Department of Orthopaedics, Malmo University Hospital, 205 02 Malmo, Sweden
    Diabetes Metab Res Rev 24:S76-80. 2008
    Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments...
  50. ncbi The diabetic foot: a global view
    A J Boulton
    Manchester Royal Infirmary, Manchester, UK
    Diabetes Metab Res Rev 16:S2-5. 2000
    ..that approximately 15% of the more than 150 million people with diabetes world-wide will at some stage develop diabetic foot ulceration...
  51. ncbi Variation in the recorded incidence of amputation of the lower limb in England
    N Holman
    Diabetes Health Intelligence, Yorkshire and Humber Public Health Observatory, York, UK
    Diabetologia 55:1919-25. 2012
    ..The study aimed to explore the variation in recorded incidence of lower limb amputation in England...
  52. ncbi Resource utilisation and costs associated with the treatment of diabetic foot ulcers. Prospective data from the Eurodiale Study
    L Prompers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, Maastricht, The Netherlands
    Diabetologia 51:1826-34. 2008
    The aim of the present study was to investigate resource utilisation and associated costs in patients with diabetic foot ulcers and to analyse differences in resource utilisation between individuals with or without peripheral arterial ..
  53. pmc A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?
    Alexandra Alvarsson
    Rolf Luft Centre for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cardiovasc Diabetol 11:18. 2012
    ..Hospital in Solna (KS) following the introduction of consensus guidelines for treatment and prevention of diabetic foot complications, and to identify risk groups of lower extremity amputations that should be targeted for ..
  54. pmc Platelet-rich plasma: support for its use in wound healing
    Kathleen M Lacci
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8089, USA
    Yale J Biol Med 83:1-9. 2010
    ..recombinant human platelet-derived growth factor-BB isomer (rhPDGF-BB) is an efficacious treatment of chronic diabetic foot ulceration...
  55. ncbi Soft tissue reconstruction of the diabetic foot
    Gary Peter Jolly
    New Britain General Hospital, 100 Grand Street, New Britain, CT 06050, USA
    Clin Podiatr Med Surg 20:757-81. 2003
    Treatment of wounds in the diabetic foot presents a set of difficult problems that requires "out of the box" thinking...
  56. ncbi Expert opinion on the management of infections in the diabetic foot
    B A Lipsky
    VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Diabetes Metab Res Rev 28:163-78. 2012
    This update of the International Working Group on the Diabetic Foot incorporates some information from a related review of diabetic foot osteomyelitis (DFO) and a systematic review of the management of infection of the diabetic foot...
  57. doi Diagnostics and treatment of the diabetic foot
    Jan Apelqvist
    Department of Endocrinology, University Hospital of Skåne SUS, 205 02, Malmo, Sweden
    Endocrine 41:384-97. 2012
    ..Patients with diabetic foot ulcer and decreased perfusion do often not have rest pain or claudication and as a consequence non-invasive ..
  58. ncbi Randomized clinical trial comparing OASIS Wound Matrix to Regranex Gel for diabetic ulcers
    Jeffrey A Niezgoda
    Center for Comprehensive Wound Care and Hyperbaric Oxygen Therapy, St Luke s Medical Center, Milwaukee, WI, USA
    Adv Skin Wound Care 18:258-66. 2005
    To compare healing rates at 12 weeks for full-thickness diabetic foot ulcers treated with OASIS Wound Matrix, an acellular wound care product, versus Regranex Gel.
  59. ncbi The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review
    S A Bus
    Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 24:S162-80. 2008
    ..review was to systematically assess the literature and to determine the available evidence on the use of footwear and offloading interventions for ulcer prevention, ulcer treatment, and plantar pressure reduction in the diabetic foot.
  60. pmc Wound assessment
    Joseph E Grey
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:285-8. 2006
  61. ncbi Priorities in offloading the diabetic foot
    Sicco A Bus
    Academic Medical Centre, Department of Rehabilitation, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 28:54-9. 2012
    Biomechanical factors play an important role in diabetic foot disease. Reducing high foot pressures (i.e. offloading) is one of the main goals in healing and preventing foot ulceration...
  62. pmc Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, 1959 NE Pacific Street, Box 356524, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 56:687-96. 2008
    ..A better understanding of molecular mechanisms involved in keratinocyte migration may lead to molecular targets for therapies for impaired wound healing...
  63. ncbi New and experimental approaches to treatment of diabetic foot ulcers: a comprehensive review of emerging treatment strategies
    R Eldor
    Diabetes Research Centre, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel
    Diabet Med 21:1161-73. 2004
    b>Diabetic foot ulcers occur in up to 15% of all diabetic patients and are a leading cause of nontraumatic amputation worldwide...
  64. doi The ankle--brachial index and the diabetic foot: a troublesome marriage
    Dimitri Aerden
    Diabetic Foot Clinic, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Ann Vasc Surg 25:770-7. 2011
    ..The aims of this study were (1) to confirm the notion that the ABI poorly predicts PAD in the diabetic foot, (2) to determine whether arterial calcifications can be blamed, and (3) to establish the role of the ..
  65. ncbi Advanced plastic surgery techniques for soft tissue coverage of the diabetic foot
    Thomas Zgonis
    Department of Orthopaedics Podiatry Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7776, San Antonio, TX 78229, USA
    Clin Podiatr Med Surg 24:547-68, x. 2007
    Obtaining stable, durable, and functional wound closure of a diabetic foot wound or open pedal amputation through plastic surgical techniques is essential to limit the potential for repeated ulceration, infection, and "supra-pedal" ..
  66. ncbi Knowledge and practice of foot care in people with diabetes
    R D Pollock
    Diabetes Research Group and Life Course and Paediatric Research Group, School of Clinical Medical Sciences, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 64:117-22. 2004
    ..To determine knowledge and practice of foot care in people with diabetes...
  67. ncbi Admission trends over 8 years for diabetic foot ulceration in a specialized diabetes unit in cameroon
    Andre Pascal Kengne
    The George Institute for International Health, The University of Sydney, Australia
    Int J Low Extrem Wounds 8:180-6. 2009
    ..With one exception, the amputation rate of 16% (95% CI = 11%-20%) was similar across years. Foot ulcer is a major cause of hospital admission and bed use for diabetes in Cameroon...
  68. ncbi Patient and professional perspectives on prescribed therapeutic footwear for people with diabetes: a vignette study
    Maxine Johnson
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    Patient Educ Couns 64:167-72. 2006
    ..This article draws on a qualitative study to identify and discuss patient and health professional views of the use of therapeutic footwear for people with diabetes-related foot complications...
  69. ncbi Challenges for management of the diabetic foot in Africa: doing more with less
    Zulfiqarali G Abbas
    Department of Internal Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Int Wound J 4:305-13. 2007
    ..Gangrene and infections are two of the more serious sequelae of diabetic foot ulcer disease that cause long-standing disability, loss of income, amputation or death...
  70. doi Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers
    Aaron G Paul
    Department of Orthopaedic Surgery, Sarawak General Hospital, Sarawak, Malaysia
    Int Wound J 6:39-46. 2009
    ..therapy (MDT) with the sterile larvae of Lucilia cuprina (a tropical blowfly maggot) for the treatment of diabetic foot ulcers. Literature thus far has only reported results with the temperate maggot, Lucilia sericata...
  71. pmc Developing and validating a risk score for lower-extremity amputation in patients hospitalized for a diabetic foot infection
    Benjamin A Lipsky
    Department of Medicine, University of Washington, Seattle, WA, USA
    Diabetes Care 34:1695-700. 2011
    b>Diabetic foot infection is the predominant predisposing factor to nontraumatic lower-extremity amputation (LEA), but few studies have investigated which specific risk factors are most associated with LEA...
  72. pmc Depression and incident diabetic foot ulcers: a prospective cohort study
    LISA H WILLIAMS
    Department of Medicine, Division of Dermatology, University of Washington, Seattle, Wash, USA
    Am J Med 123:748-754.e3. 2010
    To test whether depression is associated with an increased risk of incident diabetic foot ulcers.
  73. doi Role of magnetic resonance imaging in the evaluation of diabetic foot with suspected osteomyelitis
    U Rozzanigo
    Diagnostic Imaging Unit, Carlo Poma Hospital, Viale Albertoni 1, 46100, Mantua, Italy
    Radiol Med 114:121-32. 2009
    This study evaluated Magnetic Resonance Imaging (MRI) in infected diabetic foot ulcers.
  74. ncbi Influence of bioengineered skin substitutes on diabetic foot ulcer and venous leg ulcer outcomes
    C Barber
    ASERNIP S, Royal Australasian College of Surgeons, Stepney, Australia
    J Wound Care 17:517-27. 2008
    ..systematic review indicates that bioengineered skin substitutes with a dermal component may improve healing outcomes in diabetic foot ulcers and venous leg ulcers. However, better designed trials with longer follow-up periods are needed.
  75. doi Diabetes foot self-care practices in the German population
    Sascha Schmidt
    Hessian Institute of Nursing Research Frankfurt Main, University of Applied Sciences, Frankfurt am Main, Germany
    J Clin Nurs 17:2920-6. 2008
    The object of this study was to find out which self-care activities patients with diabetes perform to prevent diabetic foot syndrome (DFS) and to look for differences between patient groups (diabetes education and foot at risk).
  76. ncbi Can the use of a topical antifungal nail lacquer reduce risk for diabetic foot ulceration? Results from a randomised controlled pilot study
    David G Armstrong
    Scholl s Center for Lower Extremity Ambulatory Research CLEAR at Rosalind Franklin University of Medicine, 3333 Green Bay Road, Chicago, IL 60064, USA
    Int Wound J 2:166-70. 2005
    ..In this randomised controlled trial, 70 persons at high risk for diabetic foot ulceration were enrolled into a preventative care program involving daily self-inspection with the possible ..
  77. ncbi Diabetic foot ulcers and infections: current concepts
    Jason H Calhoun
    Department of Orthopaedics and Rehabilitation, University of Texas Medical Branch, Galveston, USA
    Adv Skin Wound Care 15:31-42; quiz 44-5. 2002
  78. doi Angiosomes and wound care in the diabetic foot
    Mark W Clemens
    Department of Plastic Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
    Foot Ankle Clin 15:439-64. 2010
    ..This article focuses on the surgical implications of angiosomes of the foot and ankle and their arterial-arterial connections...
  79. ncbi Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures
    Eric Senneville
    Diabetic Foot Clinic, Dron Hospital, Tourcoing, France
    Clin Infect Dis 42:57-62. 2006
    We assessed the diagnostic value of swab cultures by comparing them with corresponding cultures of percutaneous bone biopsy specimens for patients with diabetic foot osteomyelitis.
  80. ncbi Treatment of diabetic foot infection with hyperbaric oxygen therapy
    Chin En Chen
    Department of Orthopedic Surgery, Golden Hospital, 12 2, Minsheng E Rd, Pingtung City 900, Taiwan, ROC
    Foot Ankle Surg 16:91-5. 2010
    This study was performed to evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of the infected diabetic foot.
  81. doi Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream
    Benjamin A Lipsky
    Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98116 1597, USA
    Clin Infect Dis 47:1537-45. 2008
    Topical antimicrobial therapy of infected diabetic foot ulcers can focus on the wound and avoid the adverse effects of systemic anti-infective agents...
  82. doi Predictive model of short-term amputation during hospitalization of patients due to acute diabetic foot infections
    José Barberán
    Infectious Diseases Department, Hospital Central de la Defensa Gomez Ulla, Madrid, Spain
    Enferm Infecc Microbiol Clin 28:680-4. 2010
    Factors predicting short-term amputation during hospital treatment of patients admitted for acute diabetic foot infections are of interest for clinicians managing the acute episode.
  83. ncbi Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer
    Elizabeth Bosede Bolajoko
    Department of Chemical Pathology, University of Limpopo, Medunsa Campus, Garankuwa
    S Afr Med J 98:614-7. 2008
    Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer...
  84. ncbi Negative-pressure wound therapy and diabetic foot amputations: a retrospective study of payer claims data
    Robert G Frykberg
    Podiatry Section, Carl T Hayden Veterans Administration Medical Center, Phoenix, AZ 85012, USA
    J Am Podiatr Med Assoc 97:351-9. 2007
    This study was undertaken to assess the benefits of negative-pressure wound therapy (NPWT) versus traditional wound therapies in reducing the incidence of lower-extremity amputations in patients with diabetic foot ulcers.
  85. ncbi [Diabetic foot and risk factors]
    V Martín Borge
    Unidad de Diabetes, Hospital Universitario La Paz, Madrid
    An Med Interna 24:263-6. 2007
    To identify clinic and metabolic risk factors for diabetic neuropathy and peripheral arterial disease in patients evaluated in a diabetic foot unit care.
  86. pmc Prevalence of risk factors for diabetic foot complications
    Fatma Al-Maskari
    Department of Community Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, PO Box 17666, UAE
    BMC Fam Pract 8:59. 2007
    ..The aim of this study was to determine the prevalence and risk factors for foot complications among diabetic patients in Al-Ain district, United Arab Emirates (UAE)...
  87. ncbi Assessment and treatment of diabetic foot ulcer
    A Shojaie Fard
    Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Int J Clin Pract 61:1931-8. 2007
    ..A critical triad of neuropathy, minor foot trauma and foot deformity was found in > 63% of diabetic foot ulcers (DFU). Peripheral vascular disease (PVD) has been identified in 30% of foot ulcers...
  88. ncbi Diabetes and bone: advantages and limitations of radiological, radionuclide and hybrid techniques in the assessment of diabetic foot
    G Gnanasegaran
    Department of Nuclear Medicine, Guys and St Thomas Hospital NHS Foundation Trust Hospital, London, UK
    Minerva Endocrinol 34:237-54. 2009
    ..In this review we discuss the efficacy of radiological and radionuclide techniques in the assessment of diabetic foot infection.
  89. doi Outcome of diabetic foot osteomyelitis treated nonsurgically: a retrospective cohort study
    Eric Senneville
    Diabetic Foot Clinic, Dron Hospital, Tourcoing, France
    Diabetes Care 31:637-42. 2008
    The purpose of this article was to identify criteria predictive of remission in nonsurgical treatment of diabetic foot osteomyelitis.
  90. pmc Multi-plug insole design to reduce peak plantar pressure on the diabetic foot during walking
    Ricardo L Actis
    Engineering Software Research and Development, Inc, 111 West Port Plaza, Suite 825, St Louis, MO 63146, USA
    Med Biol Eng Comput 46:363-71. 2008
    ....
  91. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
    ..gradient gel electrophoresis were utilized to survey the major populations of bacteria that occur in the pathogenic biofilms of three types of chronic wound types: diabetic foot ulcers (D), venous leg ulcers (V), and pressure ulcers (P).
  92. ncbi Psychosocial and behavioral aspects of diabetic foot lesions
    Loretta Vileikyte
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    Curr Diab Rep 8:119-25. 2008
    This article reviews key findings from recently conducted and ongoing studies into how patients adapt to diabetic foot complications by focusing on two areas...
  93. pmc The treatment of diabetic foot infections: focus on ertapenem
    Michael Edmonds
    Diabetic Foot Clinic, King s College Hospital, Denmark Hill, London, UK
    Vasc Health Risk Manag 5:949-63. 2009
    Clinically, 3 distinct stages of diabetic foot infection may be recognized: localized infection, spreading infection and severe infection. Each of these presentations may be complicated by osteomyelitis...
  94. ncbi Epidermal growth factor intralesional infiltrations can prevent amputation in patients with advanced diabetic foot wounds
    Jorge Berlanga Acosta
    Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Havana City, Cuba
    Int Wound J 3:232-9. 2006
    ..5 +/- 4.9 days. Wound recurrence after 1 year of follow-up appeared in only one patient. Preliminary evidences suggest that EGF intralesional infiltrations may be effective in reducing diabetic lower limb amputation...
  95. ncbi Diabetic foot infection: usefulness of SPECT/CT for 99mTc-HMPAO-labeled leukocyte imaging
    Luca Filippi
    Section of Nuclear Medicine, Ospedale Maggiore, Trieste, Italy
    J Nucl Med 50:1042-6. 2009
    Our aim was to evaluate the role of SPECT/CT for the diagnosis of diabetic foot infection by labeled leukocytes.
  96. ncbi Clinical profile and management outcome of diabetic foot ulcers in a tertiary care hospital
    Khalid Mehmood
    Department of Medicine, Down University of Health Sciences and Civil Hospital, Karachi
    J Coll Physicians Surg Pak 18:408-12. 2008
    To determine major risk factors and management outcome of diabetic foot ulcers in order to prevent amputation.
  97. ncbi The diabetic foot: perspectives from Chennai, South India
    Vijay Viswanathan
    M V Hospital for Diabetes and Diabetes Research Centre, Royapuram, Chennai, India
    Int J Low Extrem Wounds 6:34-6. 2007
    ..Prompt and aggressive treatment of diabetic foot ulcers can often prevent exacerbation of the problem and eliminate the potential for amputation...
  98. doi Diabetic foot infections: A need for innovative assessments
    Timothy K Fisher
    University of Arizona, Tucson, 85724, USA
    Int J Low Extrem Wounds 9:31-6. 2010
    ..Adopting these advances in diagnosis and treatment may help with overall prognosis and reduce health care costs...
  99. doi Selective primary angioplasty following an angiosome model of reperfusion in the treatment of Wagner 1-4 diabetic foot lesions: practice in a multidisciplinary diabetic limb service
    Vlad Adrian Alexandrescu
    Department of Surgery, Princesse Paola Hospital, Marche en Famenne, Belgium
    J Endovasc Ther 15:580-93. 2008
    ....
  100. pmc Patients' perspectives on foot complications in type 2 diabetes: a qualitative study
    Lone Gale
    Department of Social Medicine, University of Bristol, Horfield Health Centre, Bristol
    Br J Gen Pract 58:555-63. 2008
    ..Foot ulceration is a major health problem for people with diabetes. To minimise the risk of ulceration, patients are advised to perform preventive foot self-care...
  101. doi Facility-level variations in patient-reported footcare knowledge sufficiency: implications for diabetes performance measurement
    Mangala Rajan
    Center for Healthcare Knowledge Management, Department of Veteran Affairs New Jersey Health Care System, East Orange, NJ, United States
    Prim Care Diabetes 1:147-53. 2007
    ..To evaluate medical center variation in self-reported knowledge of footcare practices by veterans at high risk for lower extremity complications...

Research Grants89

  1. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    ..Wound Electronic Medical Record (OWEMR) as a clinical intervention tool reduces amputations resulting from diabetic foot ulcers (DFUs) in a variety of healthcare settings...
  2. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2010
    ..b>Diabetic foot ulcers have an increased risk of infection due to the slow healing times caused by poor blood circulation in ..
  3. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2011
    ..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, ..
  4. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2010
    ..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, ..
  5. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute and chronic wounds such as diabetic foot ulcers represent a major area of medical concern...
  6. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    ..of dead, damaged and/or infected tissue from thermal burn wounds and a certain subset of ischemic and necrotic diabetic foot wounds is a commonly utilized wound preparation modality before the application of fillers, dressings or ..
  7. Oklahoma Center on American Indian Diabetes Health Disparities
    Joseph Henderson; Fiscal Year: 2009
    ..and Cultural Adaptation in the American Indian Population with Diabetes, 2) Weight Bearing Activity: Links to Diabetic Foot Health in American Indians, 3) Regular Moderate Exercise in Elementary-aged American Indians: Steady Activity ..
  8. Oklahoma Center on American Indian Diabetes Health Disparities
    Joseph Henderson; Fiscal Year: 2007
    ..and Cultural Adaptation in the American Indian Population with Diabetes, 2) Weight Bearing Activity: Links to Diabetic Foot Health in American Indians, 3) Regular Moderate Exercise in Elementary-aged American Indians: Steady Activity ..
  9. Oklahoma Center on American Indian Diabetes Health Disparities
    JOSEPH NEIL HENDERSON; Fiscal Year: 2010
    ..and Cultural Adaptation in the American Indian Population with Diabetes, 2) Weight Bearing Activity: Links to Diabetic Foot Health in American Indians, 3) Regular Moderate Exercise in Elementary-aged American Indians: Steady Activity ..
  10. Mechanisms of Neuropeptides Action in Diabetes
    JANICE ZABOLOTNY; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Peripheral neuropathy plays a major role in the development of diabetic foot ulceration (DFU) because of the pain insensitivity that allows prolonged tissue injury till a chronic wound has been ..
  11. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2003
    ..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
  12. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2004
    ..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
  13. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2002
    ..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
  14. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
  15. DIABETIC FOOT ULCER DEVICE
    PAUL BUREK; Fiscal Year: 1999
    b>Diabetic foot ulcers account for 55,000 amputations per year and are the leading cause of diabetic patient hospitalizations...
  16. DIABETIC FOOT ULCER DEVICE
    Jeffrey Jensen; Fiscal Year: 2000
    b>Diabetic foot ulcers account for 55,000 amputations per year and are the leading cause of diabetic patient hospitalizations...
  17. DIABETIC FOOT ULCER DEVICE
    PAUL BUREK; Fiscal Year: 2000
    b>Diabetic foot ulcers account for 55,000 amputations per year and are the leading cause of diabetic patient hospitalizations...
  18. Development of an Antimicrobial Cellular Therapeutic for Inhibition of Biofilm Fo
    ALLEN R COMER; Fiscal Year: 2011
    ..As of 2006, infections of diabetic foot ulcers resulted in 82,000 amputations each year and it has been estimated that these numbers will increase by ..
  19. Development of an Antimicrobial Cellular Therapeutic for Inhibition of Biofilm Fo
    ALLEN R COMER; Fiscal Year: 2010
    ..As of 2006, infections of diabetic foot ulcers resulted in 82,000 amputations each year and it has been estimated that these numbers will increase by ..
  20. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..5 million Americans annually, particularly the elderly. Diseases within this family include diabetic foot ulcers, venous stasis ulcers, and pressure ulcers...
  21. TGF-Beta Antagonists for Accelerating Wound Healing
    Shuan S Huang; Fiscal Year: 2010
    ..In spite of these large costs for the care and the treatment of diabetic foot ulcers, each year 82,000 limb amputations are still performed on US patients with diabetic ulcers because ..
  22. Measurement and classification of vertical and shear forces and distributions in
    HASAN GULER; Fiscal Year: 2009
    ..to biomechanists, podiatrists, physical therapists, and doctors specializing in the treatment of diabetes and diabetic foot complications...
  23. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..b>Diabetic foot ulcers cost tens of thousands of dollars to treat and are the leading cause of lower extremity amputation...
  24. TGF-BETA FOR PLEURODESIS
    Kirk Lane; Fiscal Year: 2000
    ..The therapeutic use of TGF-beta is currently being explored for diabetic foot ulcers in phase II/III trials. Pleurodesis would be a new indication for this compound...
  25. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, ..
  26. Transcutaneous Raman Spectroscopy for Diagnosis of Diabetic Osteomyelitis
    Blake J Roessler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Transcutaneous Raman Spectroscopy for Diagnosis of Diabetic Osteomyelitis Diabetic foot ulcers often lead to metatarsal or calcaneal osteomyelitis, a serious complication that can require prolonged ..
  27. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2002
    ..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
  28. Role of Neuropeptides in Diabetic Foot Problems
    ARISTIDIS contact VEVES; Fiscal Year: 2010
    ..Impaired wound healing is an important clinical problem in diabetes resulting in failure to completely heal diabetic foot ulcers and more that 75,000 lower extremity amputations annually...
  29. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    Marjana Tomic Canic; Fiscal Year: 2009
    ..is to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs)...
  30. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    MARJANA contact TOMIC CANIC; Fiscal Year: 2010
    ..is to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs)...
  31. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..A large proportion of patients with chronic wounds, such as diabetic foot ulcers, and venous leg ulcers, are unresponsive to conventional treatment, such as moist dressings...
  32. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2007
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  33. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  34. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  35. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2006
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  36. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2005
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  37. Measurement of Vertical and Shear Forces and Distributions in the Diabetic Foot
    HASAN C GULER; Fiscal Year: 2011
    ..to biomechanists, podiatrists, physical therapists, and doctors specializing in the treatment of diabetes and diabetic foot complications...
  38. Emotional Stress and Wound Healing in Diabetes
    Andrew Boulton; Fiscal Year: 2007
    b>Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
  39. The Development and Testing of a Sonic Treatment Brush for Diabetic Foot Ulcers
    ROBERT AKRIDGE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Non-healing diabetic foot ulcers are potentially a limb- and life-threatening complication of chronic diabetes mellitus and associated peripheral neuropathy...
  40. Emotional Stress and Wound Healing in Diabetes
    Loretta Vileikyte; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
  41. Emotional Stress and Wound Healing in Diabetes
    Loretta Vileikyte; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Diabetic foot ulcers are common and may lead to amputation: efforts to improve foot ulcer healing would have an impact on the frequency of lower limb amputation in the USA...
  42. Clinical Testing of Hyperspectral Assessment & Prediction of Diabetic Foot Ulcers
    KEVIN SCHOMACKER; Fiscal Year: 2007
    ..We believe FHSI can have positive impact on quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs. ..
  43. Hyperspectral Assessment & Prediction of Diabetic Foot U
    Jenny Freeman; Fiscal Year: 2006
    ..We believe FHSI can have positive impact on quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs. ..
  44. Hyperspectral Assessment & Prediction of Diabetic Foot U
    Jenny Freeman; Fiscal Year: 2005
    ..We believe FHSI can have positive impact on quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs. ..
  45. OBJECTIVE STUDY OF THERAPEUTIC FOOTWEAR IN DIABETES
    Peter Cavanagh; Fiscal Year: 1991
    ..study is designed to fill this void by a systematic investigation of footwear typically prescribed for the diabetic foot. Based on the assumption that a reduction in plantar pressure is the desired mechanical effect of footwear ..
  46. Topical Salicylanilides to Treat Diabetic Foot Ulcer
    Joseph Dunn; Fiscal Year: 2002
    ..class of patented, Lipophilic, Antimicrobial, Anti-inflammatory Drugs (LAADs) for the treatment of Diabetic Foot Ulcer (DFU)...
  47. OBJECTIVE STUDY OF THERAPEUTIC FOOTWEAR IN DIABETES
    Peter Cavanagh; Fiscal Year: 1993
    ..study is designed to fill this void by a systematic investigation of footwear typically prescribed for the diabetic foot. Based on the assumption that a reduction in plantar pressure is the desired mechanical effect of footwear ..
  48. Transdermal Delivery of Deferoxamine to Prevent and Treat Diabetic Wounds
    Geoffrey C Gurtner; Fiscal Year: 2011
    ..b>Diabetic foot ulcers represent one of the most common sequelae of diabetes-associated dysfunction in new blood vessel growth...
  49. Image Guidance Method for Diabetic Foot Surgery
    IRVING WEINBERG; Fiscal Year: 2010
    ..Providing additional confidence might allow surgeons and podiatrists to be more conservative in their resections, thereby improving patients'quality of life. ..
  50. Circumferential Neuropathic Foot Protector System (CNEP)
    Jeffrey Jensen; Fiscal Year: 2001
    b>Diabetic foot complications result in over 67,000 lower extremity amputations annually and cause more hospitalizations than any other single complication of diabetes...
  51. Skin Interface Friction Transducer
    JEFFREY SCHOESS; Fiscal Year: 2003
    ..is 15 to 46 times higher in diabetics than persons without diabetic mellitus, with the vast majority of diabetic foot complications resulting in amputation due to formation of skin ulcers...
  52. Diabetic Foot Ulcer Healing by Load Relieving Dressings
    Joseph Loomis; Fiscal Year: 2006
    ..abstract_text> ..
  53. Diabetic Foot Ulcer Healing by Load Relieving Dressings
    Joseph Loomis; Fiscal Year: 2005
    ..abstract_text> ..
  54. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    ANTON LEWIS USALA; Fiscal Year: 2000
    Progression of diabetic foot ulcers is the leading cause of lower limb amputation in the U.S...
  55. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2012
    ..b>Diabetic foot ulcers (DFUs) are one of the major complications of diabetes mellitus leadin to lower extremity amputation for ..
  56. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 1999
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  57. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2003
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  58. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2002
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  59. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2001
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  60. Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
    Paul Hamilton; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary/Abstract: Diabetic foot ulcers are a significant health problem that imposes high costs on both patients and society (Boulton, Vileikyte et al. 2005)...
  61. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2000
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  62. Enhancing diabetic foot education by viewing personal plantar pressures
    Jinsup Song; Fiscal Year: 2009
    ..interest in foot-type biomechanics, footwear design, and other conservative interventions ultimately to reduce diabetic foot complications. Over time, Dr. Song recognized the inadequacy of the current diabetic foot care education...
  63. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2002
    ..The estimated annual cost of $9 billion doesn't include the pam, suffering, and morbidity of diabetic foot ulcers...
  64. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2007
    ..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
  65. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2009
    ..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
  66. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2010
    ..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
  67. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2010
    ..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
  68. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2003
    ..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
  69. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..The estimated annual cost of $9 billion doesn't include the pam, suffering, and morbidity of diabetic foot ulcers...
  70. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2000
    ..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
  71. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2001
    ..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
  72. Impaired Wound Healing in Diabetic Foot Ulceration
    Aristidis Veves; Fiscal Year: 2007
    b>Diabetic foot ulceration (DFU) is a major problem that significantly impairs the quality of life of the patient, leads to prolonged hospitalization and may require a major amputation...
  73. Impaired Wound Healing in Diabetic Foot Ulceration
    Aristidis Veves; Fiscal Year: 2009
    b>Diabetic foot ulceration (DFU) is a major problem that significantly impairs the quality of life of the patient, leads to prolonged hospitalization and may require a major amputation...
  74. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2002
    ..In the majority of diabetic subjects, the underlying factor which contributes to eventual amputation is the diabetic foot ulcer...
  75. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2001
    ..In the majority of diabetic subjects, the underlying factor which contributes to eventual amputation is the diabetic foot ulcer...
  76. Innovative intervention for healing of diabetic ulcers
    Joyce Stechmiller; Fiscal Year: 2005
    ..this study is: (1) to determine the effectiveness of topical doxycycline to accelerate the healing of chronic diabetic foot ulcers, (2) describe the molecular changes that occur in diabetic foot ulcers as they heal and (3) detect ..
  77. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..In the majority of diabetic subjects, the underlying factor which contributes to eventual amputation is the diabetic foot ulcer...
  78. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2007
    ..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..
  79. Hyperspectral Imaging to Predict and Assess Foot Ulcers
    Jenny Freeman; Fiscal Year: 2004
    ..Our long-term objectives are to reduce the frequency of diabetic foot ulcers (DFU) & decrease the amputation rate in Type 1 diabetics by developing Hyperspectral Imaging for ..
  80. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    Ronald Hill; Fiscal Year: 2004
    Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27...
  81. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    Ronald Hill; Fiscal Year: 2005
    Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27...
  82. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    Ronald Hill; Fiscal Year: 2003
    Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27...
  83. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2004
    ..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
  84. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2007
    ..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
  85. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2006
    ..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..
  86. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2005
    ..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
  87. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2006
    ..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
  88. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2007
    ..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..