diabetic foot

Summary

Summary: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

Top Publications

  1. pmc Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    Research and Testing Laboratory, Lubbock, Texas, USA
    PLoS ONE 3:e3326. 2008
  2. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
  3. ncbi The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial
    William A Marston
    University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
    Diabetes Care 26:1701-5. 2003
  4. pmc Dynamic reciprocity in the wound microenvironment
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 19:134-48. 2011
  5. doi The pro-inflammatory environment in recalcitrant diabetic foot wounds
    Jorge Berlanga Acosta
    Biomedical Research Direction, Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, Avenida 31 e 158 y 190, Playa, PO Box 6162, Havana 10600, Cuba
    Int Wound J 5:530-9. 2008
  6. ncbi High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study
    L Prompers
    Department of Internal Medicine, University Hospital Maastricht, P Debeyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 50:18-25. 2007
  7. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
  8. doi The ankle--brachial index and the diabetic foot: a troublesome marriage
    Dimitri Aerden
    Diabetic Foot Clinic, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Ann Vasc Surg 25:770-7. 2011
  9. doi Diagnostics and treatment of the diabetic foot
    Jan Apelqvist
    Department of Endocrinology, University Hospital of Skåne SUS, 205 02, Malmo, Sweden
    Endocrine 41:384-97. 2012
  10. pmc Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?
    Stephanie C Wu
    Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 31:2118-9. 2008

Detail Information

Publications380 found, 100 shown here

  1. pmc Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    Research and Testing Laboratory, Lubbock, Texas, USA
    PLoS ONE 3:e3326. 2008
    ..A primary impediment to the healing of chronic wounds is biofilm phenotype infections. Diabetic foot ulcers are the most common, disabling, and costly complications of diabetes...
  2. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
    ..gradient gel electrophoresis were utilized to survey the major populations of bacteria that occur in the pathogenic biofilms of three types of chronic wound types: diabetic foot ulcers (D), venous leg ulcers (V), and pressure ulcers (P).
  3. ncbi The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial
    William A Marston
    University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
    Diabetes Care 26:1701-5. 2003
    To determine if a human fibroblast-derived dermal substitute could promote the healing of diabetic foot ulcers.
  4. pmc Dynamic reciprocity in the wound microenvironment
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 19:134-48. 2011
    ..The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered...
  5. doi The pro-inflammatory environment in recalcitrant diabetic foot wounds
    Jorge Berlanga Acosta
    Biomedical Research Direction, Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, Avenida 31 e 158 y 190, Playa, PO Box 6162, Havana 10600, Cuba
    Int Wound J 5:530-9. 2008
    ..These medical interventions are demanded to reduce amputations in an expanding diabetic population...
  6. ncbi High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study
    L Prompers
    Department of Internal Medicine, University Hospital Maastricht, P Debeyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 50:18-25. 2007
    Large clinical studies describing the typical clinical presentation of diabetic foot ulcers are limited and most studies were performed in single centres with the possibility of selection of specific subgroups...
  7. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
    b>Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes...
  8. doi The ankle--brachial index and the diabetic foot: a troublesome marriage
    Dimitri Aerden
    Diabetic Foot Clinic, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Ann Vasc Surg 25:770-7. 2011
    ..The aims of this study were (1) to confirm the notion that the ABI poorly predicts PAD in the diabetic foot, (2) to determine whether arterial calcifications can be blamed, and (3) to establish the role of the ..
  9. doi Diagnostics and treatment of the diabetic foot
    Jan Apelqvist
    Department of Endocrinology, University Hospital of Skåne SUS, 205 02, Malmo, Sweden
    Endocrine 41:384-97. 2012
    ..Patients with diabetic foot ulcer and decreased perfusion do often not have rest pain or claudication and as a consequence non-invasive ..
  10. pmc Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?
    Stephanie C Wu
    Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 31:2118-9. 2008
    Pressure mitigation is crucial for the healing of plantar diabetic foot ulcers. We therefore discuss characteristics and considerations associated with the use of offloading devices.
  11. ncbi Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot
    Jan Vojtassak
    Institute of Medical Biology and Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Neuro Endocrinol Lett 27:134-7. 2006
    ....
  12. doi Microvascular dysfunction in diabetic foot disease and ulceration
    Clare Y L Chao
    Physiotherapy Department, Queen Elizabeth Hospital, Hong Kong SAR, China
    Diabetes Metab Res Rev 25:604-14. 2009
    b>Diabetic foot disease and ulceration is a major complication that may lead to the amputation of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue breakdown in the diabetic foot...
  13. pmc Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing
    Zhao Jun Liu
    The DeWitt Daughtry Family Department of Surgery, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Antioxid Redox Signal 10:1869-82. 2008
    b>Diabetic foot disease is a major health problem, which affects 15% of the 200 million patients with diabetes worldwide...
  14. ncbi Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method
    Ronan J Canavan
    Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
    Diabetes Care 31:459-63. 2008
    ..K. We present here accurate data on trends in diabetes-related (DR) LEAs and non-DRLEAs in the South Tees area over a continuous 5-year period...
  15. ncbi Diagnosis and treatment of diabetic foot infections
    Benjamin A Lipsky
    Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108 9804, USA
    Clin Infect Dis 39:885-910. 2004
  16. ncbi Reduction in diabetic amputations over 11 years in a defined U.K. population: benefits of multidisciplinary team work and continuous prospective audit
    Singhan Krishnan
    Ipswich Hospital, Diabetes Center, Heath Road, Ipswich, Suffolk IP4 5PD, UK
    Diabetes Care 31:99-101. 2008
    ..To assess changes in diabetic lower-extremity amputation rates in a defined relatively static population over an 11-year period following the introduction of a multidisciplinary foot team...
  17. ncbi The diabetic foot: from art to science. The 18th Camillo Golgi lecture
    A J M Boulton
    Department of Medicine, Manchester Royal Infirmary, UK
    Diabetologia 47:1343-53. 2004
    b>Diabetic foot ulceration represents a major medical, social and economic problem all over the world. While more than 5% of diabetic patients have a history of foot ulceration, the cumulative lifetime incidence may be as high as 15%...
  18. doi Trends in lower extremity amputations in people with and without diabetes in England, 1996-2005
    Eszter Panna Vamos
    Department of Primary Care and Public Health, Imperial College London, UK
    Diabetes Res Clin Pract 87:275-82. 2010
    ..To examine trends in non-traumatic lower extremity amputations over a 10-year-period in people with and without diabetes (DM) in England...
  19. ncbi Bacterial load predicts healing rate in neuropathic diabetic foot ulcers
    Ling Xu
    Department of Endocrinology, Royal Prince Alfred Hospital, Blackburn Building, University of Sydney, Sydney, NSW, Australia
    Diabetes Care 30:378-80. 2007
  20. ncbi Muscle weakness and foot deformities in diabetes: relationship to neuropathy and foot ulceration in caucasian diabetic men
    Carine H M van Schie
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Diabetes Care 27:1668-73. 2004
    ..To examine the relationships among muscle weakness, foot deformities, and peroneal and tibial nerve conduction velocity in diabetic and nondiabetic men...
  21. ncbi The role of limited joint mobility in diabetic patients with an at-risk foot
    Stefan Zimny
    Evangelisches Krankenhaus Bethesda, Akademisches Lehrkrankenhaus der Universität Düsseldorf, Medizinische Klinik I, Duisburg, Germany
    Diabetes Care 27:942-6. 2004
    ..To assess the role of limited joint mobility (LJM) in causing abnormal high plantar pressures in the forefoot of diabetic patients with an at-risk foot...
  22. pmc Assessing diabetic foot ulcer development risk with hyperspectral tissue oximetry
    Dmitry Yudovsky
    University of California, Los Angeles, Henry Samueli School of Engineering and Applied Science Biomedical Inter Department Program, Los Angeles, California 90095 1597, USA
    J Biomed Opt 16:026009. 2011
    ..We aim to assess the use of hyperspectral tissue oximetry in predicting the risk of diabetic foot ulcer formation...
  23. pmc Severity of diabetic foot infection and rate of limb salvage
    Dane K Wukich
    Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Foot Ankle Int 34:351-8. 2013
    ..complications in patients with diabetes mellitus (DM), and proper classification of the severity of diabetic foot infection (DFI) is important in determining an effective antibiotic regimen, the need for hospitalization and ..
  24. ncbi Factors in diabetic footwear compliance
    Daniel J Macfarlane
    Colorado Wound Care, Englewood 80110, USA
    J Am Podiatr Med Assoc 93:485-91. 2003
    b>Diabetic foot complications are costly and often recurrent. The use of diabetic footwear has been shown to be effective in reducing the incidence of diabetic foot ulcerations...
  25. pmc History of foot ulcer increases mortality among individuals with diabetes: ten-year follow-up of the Nord-Trøndelag Health Study, Norway
    Marjolein M Iversen
    Faculty of Health and Social Sciences, Bergen University College, Bergen, Norway
    Diabetes Care 32:2193-9. 2009
    ..To compare mortality rates for individuals with diabetes with and without a history of foot ulcer (HFU) and with that for the nondiabetic population...
  26. ncbi A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems
    S O Oyibo
    Department of Medicine and Diabetes, Manchester Royal Infirmary, UK
    Diabetes Care 24:84-8. 2001
    ..In this study the following two ulcer classification systems were applied to new foot ulcers to compare them as predictors of outcome: the Wagner (grade) and the University of Texas (LT) (grade and stage) wound classification systems...
  27. pmc Diabetic foot biomechanics and gait dysfunction
    James S Wrobel
    Center for Lower Extremity Ambulatory Research at Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Diabetes Sci Technol 4:833-45. 2010
    b>Diabetic foot complications represent significant morbidity and precede most of the lower extremity amputations performed. Peripheral neuropathy is a frequent complication of diabetes shown to affect gait...
  28. doi Present and new techniques and devices in the treatment of DFU: a critical review of evidence
    Finn Gottrup
    Department of Dermatology, D42, Copenhagen Wound Healing Center, Bispebjerg University Hospital, Copenhagen NV, Denmark
    Diabetes Metab Res Rev 28:64-71. 2012
    ..We performed a critical review of evidence of present and new techniques and devices in the treatment of diabetic foot ulcer...
  29. pmc Diabetic foot ulcers and vascular insufficiency: our population has changed, but our methods have not
    David G Armstrong
    Southern Arizona Limb Salvage Alliance, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Diabetes Sci Technol 5:1591-5. 2011
    b>Diabetic foot complications are increasing in prevalence worldwide. Care and attention to these complications have improved greatly...
  30. doi New monitoring technology to objectively assess adherence to prescribed footwear and assistive devices during ambulatory activity
    Sicco A Bus
    Human Performance Laboratory, Department of Rehabilitation, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Arch Phys Med Rehabil 93:2075-9. 2012
    ..To assess the validity and feasibility of a new temperature-based adherence monitor to measure footwear use...
  31. pmc Mechanisms involved in the development and healing of diabetic foot ulceration
    Thanh Dinh
    Microcirculation Laboratory and Joslin Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Diabetes 61:2937-47. 2012
    We examined the role of vascular function and inflammation in the development and failure to heal diabetic foot ulcers (DFUs). We followed 104 diabetic patients for a period of 18.4 ± 10.8 months...
  32. doi Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients
    S Kirana
    Diabetes Centre, Heart and Diabetes Centre NRW, Ruhr University Bochum, Germany
    Int J Clin Pract 66:384-93. 2012
    ..The aim of this study was to evaluate safety, feasibility and efficacy of transplantation of bone marrow derived cellular products regarding improvement in microcirculation and lowering of amputation rate...
  33. pmc Evaluation and optimization of therapeutic footwear for neuropathic diabetic foot patients using in-shoe plantar pressure analysis
    Sicco A Bus
    Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Care 34:1595-600. 2011
    Therapeutic footwear for diabetic foot patients aims to reduce the risk of ulceration by relieving mechanical pressure on the foot. However, footwear efficacy is generally not assessed in clinical practice...
  34. doi Expert opinion on the management of infections in the diabetic foot
    B A Lipsky
    VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Diabetes Metab Res Rev 28:163-78. 2012
    This update of the International Working Group on the Diabetic Foot incorporates some information from a related review of diabetic foot osteomyelitis (DFO) and a systematic review of the management of infection of the diabetic foot...
  35. doi Practical guidelines on the management and prevention of the diabetic foot: based upon the International Consensus on the Diabetic Foot (2007) Prepared by the International Working Group on the Diabetic Foot
    J Apelqvist
    Department of Endocrinology, University Hospital of Malmo, S 205 02 Malmo, Sweden
    Diabetes Metab Res Rev 24:S181-7. 2008
  36. doi A systematic review of interventions to enhance the healing of chronic ulcers of the foot in diabetes
    F L Game
    Foot Ulcer Trials Unit, Nottingham University Hospitals Trust, Nottingham, UK
    Diabetes Metab Res Rev 28:119-41. 2012
    The outcome of management of diabetic foot ulcers is poor, and there is continuing uncertainty concerning optimal approaches to management...
  37. doi Genetic and epigenetic events in diabetic wound healing
    Haloom Rafehi
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Int Wound J 8:12-21. 2011
    ..Inevitably, this will be accompanied by an increase in the prevalence of diabetic complications, including diabetic foot ulcers...
  38. ncbi Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcers
    V Krishna Mohan
    Bharat Biotech International Limited, Genome Valley, Shameerpet M, Hyderabad 500078, A P, India
    Diabetes Res Clin Pract 78:405-11. 2007
    ..coli, has shown enhanced healing of chronic diabetic foot ulcers (DFU) by significantly reducing the duration of healing in addition to providing excellent quality of ..
  39. ncbi A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital
    Ravisekhar Gadepalli
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi
    Diabetes Care 29:1727-32. 2006
    To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers...
  40. ncbi Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing
    H Brem
    Department of Surgery, The Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Arch Surg 135:627-34. 2000
    In patients with diabetic foot and pressure ulcers, early intervention with biological therapy will either halt progression or result in rapid healing of these chronic wounds.
  41. ncbi Wound-healing protocols for diabetic foot and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:85-92. 2003
    b>Diabetic foot and pressure ulcers are chronic wounds by definition. They share similar pathogeneses; i.e., a combination of increased pressure and decreased angiogenic response...
  42. ncbi Split-skin graft in the management of diabetic foot ulcers
    S M Mahmoud
    Soba University Hospital, Khartoum, Sudan
    J Wound Care 17:303-6. 2008
    To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay.
  43. ncbi Age and sex may significantly interact with diabetes on the risks of lower-extremity amputation and peripheral revascularization procedures: evidence from a cohort of a half-million diabetic patients
    Hua Fen Chen
    Department of Public Health, College of Medicine, Fu Jen Catholic University, 510 Chung Cheng Rd, Hsinchuang, Taipei Hsien, 242 Taiwan
    Diabetes Care 29:2409-14. 2006
    ....
  44. pmc Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers
    Peter Blume
    Affiliated Foot Surgeons, New Haven, Connecticut, USA
    Wound Repair Regen 19:302-8. 2011
    ..Both GAM501 and FCG appeared to be safe and well tolerated, and alternate dosing schedules hold promise to improve overall complete wound closure in adequately powered trials...
  45. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
    ..To compare the effectiveness of total-contact casts (TCCs), removable cast walkers (RCWs), and half-shoes to heal neuropathic foot ulcerations in individuals with diabetes...
  46. doi An exercise intervention to improve diabetic patients' gait in a real-life environment
    L Allet
    Care Services Directorate, Unit of Physiotherapy Research and Quality Assurance, Geneva University Hospital and University of Geneva, 1211 Geneva, Switzerland
    Gait Posture 32:185-90. 2010
    ..Gait characteristics and balance are altered in diabetic individuals. Little is known about possible treatment strategies. This study evaluated the effect of a specific training program on diabetic patients' gait...
  47. pmc Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Italy
    Cardiovasc Diabetol 9:50. 2010
    It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention...
  48. doi Using honey to heal diabetic foot ulcers
    P C Molan
    Honey Research Unit, Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
    Adv Skin Wound Care 21:313-6. 2008
  49. pmc Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008
    Ana López-de-Andrés
    Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain
    Diabetes Care 34:1570-6. 2011
    ..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
  50. pmc Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers
    Yu Liu
    Discipline of Medicine, University of Sydney, Sydney, Australia
    Diabetes Care 32:117-9. 2009
    ..We studied the relationships of diabetic ulcer wound fluid matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and transforming growth factor-beta1 (TGF-beta1) with wound healing rate...
  51. ncbi Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial
    David G Armstrong
    Scholl s Center for Lower Extremity Ambulatory Research CLEAR, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA
    Lancet 366:1704-10. 2005
    b>Diabetic foot wounds, particularly those secondary to amputation, are very complex and difficult to treat...
  52. pmc Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, 1959 NE Pacific Street, Box 356524, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 56:687-96. 2008
    ..A better understanding of molecular mechanisms involved in keratinocyte migration may lead to molecular targets for therapies for impaired wound healing...
  53. ncbi Foot complications in Type 2 diabetes: an Australian population-based study
    R J Tapp
    International Diabetes Institute, Melbourne, Australia
    Diabet Med 20:105-13. 2003
    ..To determine the prevalence and risk factors for neuropathy and peripheral vascular disease (PVD) in the Australian diabetic population and identify those at high risk of foot ulceration...
  54. doi A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes
    R J Hinchliffe
    Department of Vascular Surgery, Nottingham University Hospitals Trust, Nottingham, UK
    Diabetes Metab Res Rev 24:S119-44. 2008
    The outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness...
  55. ncbi Preventive foot care in people with diabetes
    J A Mayfield
    Bowen Research Center, Department of Family Medicine, Indiana University, Indianapolis 46202, USA
    Diabetes Care 21:2161-77. 1998
    A number of effective, low-cost strategies are available to identify and treat the person at risk for diabetic foot ulcers and lower-extremity amputation...
  56. ncbi Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers
    E B Jude
    Department of Medicine and Diabetes, Manchester Royal Infirmary and School of Biological Sciences, University of Manchester, Manchester, UK
    Diabet Med 19:440-7. 2002
    ..distribution of transforming growth factor-beta (TGF-beta) 1, 2 and 3, and TGF-beta receptor types I and II in diabetic foot ulcers, diabetic skin and normal skin by immunohistochemistry, immunofluorescence and Western blotting...
  57. ncbi Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers
    D J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Diabetes Care 24:483-8. 2001
    ....
  58. ncbi A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers
    Aristidis Veves
    Joslin Beth Israel Deaconess Foot Center, One Deaconess Rd, Boston, MA 02215, USA
    Arch Surg 137:822-7. 2002
    ..Promogran, a wound dressing consisting of collagen and oxidized regenerated cellulose, is more effective that standard care in treating chronic diabetic plantar ulcers...
  59. doi 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections
    Benjamin A Lipsky
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Clin Infect Dis 54:e132-73. 2012
    Foot infections are a common and serious problem in persons with diabetes. Diabetic foot infections (DFIs) typically begin in a wound, most often a neuropathic ulceration...
  60. ncbi Preventing foot ulcers in patients with diabetes
    Nalini Singh
    Department of Medicine, Division of Endocrinology, Veterans Affairs Puget Sound Healthcare System and University of Washington School of Medicine, Seattle 98108, USA
    JAMA 293:217-28. 2005
    ..0% to 4.1%, and the lifetime incidence may be as high as 25%. These ulcers frequently become infected, cause great morbidity, engender considerable financial costs, and are the usual first step to lower extremity amputation...
  61. doi The diabetic foot
    M P Khanolkar
    Specialist Registrar in Diabetes, Department of Diabetes and Endocrinology, Morriston Hospital, Swansea SA6 6NL, UK
    QJM 101:685-95. 2008
    ..Disease of the foot is among one of the most feared complications of diabetes. The ultimate endpoint of diabetic foot disease is amputation, which is associated with significant morbidity and mortality, besides having immense ..
  62. ncbi Wound healing and its impairment in the diabetic foot
    Vincent Falanga
    Department of Dermatology, Boston University, Boston, MA, USA
    Lancet 366:1736-43. 2005
    ..Enhanced understanding and correction of pathogenic factors, combined with stricter adherence to standards of care and with technological breakthroughs in biological agents, is giving new hope to the problem of impaired healing...
  63. ncbi Effects of ethnicity and nephropathy on lower-extremity amputation risk among diabetic veterans
    Bessie A Young
    Epidemiologic Research and Information Center, Department of Veterans Affairs, Seattle Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 26:495-501. 2003
    ..To describe ethnic differences in the risk of amputation in diabetic patients with diabetic nephropathy...
  64. ncbi Diabetic foot disorders. A clinical practice guideline (2006 revision)
    Robert G Frykberg
    Podiatric Surgery, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA
    J Foot Ankle Surg 45:S1-66. 2006
    ..Using this concept, the authors present a clinical practice guideline for diabetic foot disorders based on currently available evidence, committee consensus, and current clinical practice...
  65. ncbi Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including patients in research studies
    N C Schaper
    Department of Internal Medicine Endocrinology, University Hospital Maastricht, The Netherlands
    Diabetes Metab Res Rev 20:S90-5. 2004
    Various different systems have been proposed to classify diabetic foot ulcers, but none has gained widespread acceptance...
  66. doi Management of patients hospitalized for diabetic foot infection: results of the French OPIDIA study
    J L Richard
    Department of Diabetology and Nutritional Diseases, Caremeau University Hospital, place du Professeur Robert Debré, 30029 Nimes Cedex 9, France
    Diabetes Metab 37:208-15. 2011
    This study was an analysis of how diabetic patients with infected foot wounds are managed in hospital by departments specializing in diabetic foot pathology, including an evaluation of the outcome 1 year after discharge.
  67. pmc Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
    M Muller
    Department of Nephrology and Endocrinology, University Hospital, Grenoble, France
    Diabet Med 25:419-26. 2008
    ..In diabetic foot ulcers there is an excess of MMPs and a decrease of the tissue inhibitors of MMPs (TIMPs)...
  68. ncbi The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse
    Jeremy Rich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Diabetes 54:2904-10. 2005
    Although Staphylococcus aureus is a major pathogen implicated in diabetic foot infections, little is known about the pathogenesis of this disease. A model of S...
  69. pmc Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh, India
    PLoS ONE 8:e56022. 2013
    Staphylococcus aureus remains the predominant pathogen in diabetic foot infections and prevalence of methicillin resistant S.aureus (MRSA) strains further complicates the situation...
  70. ncbi Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial
    A Veves
    Joslin Beth Israel Deaconess Foot Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:290-5. 2001
    We assessed in a randomized prospective trial the effectiveness of Graftskin, a living skin equivalent, in treating noninfected nonischemic chronic plantar diabetic foot ulcers.
  71. ncbi Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers
    Breda Cullen
    R and DDepartment, Johnson and Johnson Advanced Wound Care, A Division of Ethicon, Gargrave, North Yorkshire, United Kingdom
    Wound Repair Regen 10:16-25. 2002
    ..We have shown that the addition of this test material to human chronic wound fluid obtained from diabetic foot ulcer patients resulted in a significant reduction in the activities of neutrophil-derived elastase, plasmin, ..
  72. doi Treatment of diabetic foot ulcers using cultured allogeneic keratinocytes--a pilot study
    Hi Jin You
    Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea
    Wound Repair Regen 20:491-9. 2012
    b>Diabetic foot ulcers often pose a difficult treatment problem. Repeated applications of cell-based products have been reported to result in acceleration of diabetic wound healing...
  73. doi Expression of antimicrobial peptides in diabetic foot ulcer
    Bruno Rivas-Santiago
    Medical Research Unit Zacatecas, Mexican Institute of Social Security IMSS, Zacatecas, Mexico
    J Dermatol Sci 65:19-26. 2012
    ..There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis...
  74. doi Predictive value of angiographic scores for the integrated management of the ischemic diabetic foot
    Irene Bargellini
    Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy
    J Vasc Surg 57:1204-12. 2013
    ..To retrospectively evaluate the agreement between the angiographic scores and the clinical outcomes after endoluminal revascularization in diabetic patients with Fontaine stage IV critical limb ischemia (CLI)...
  75. pmc Systematic review and mixed treatment comparison: dressings to heal diabetic foot ulcers
    J C Dumville
    Department of Health Sciences, University of York, Area 2, Seebohm Rowntree Building, York YO10 5DD, UK
    Diabetologia 55:1902-10. 2012
    ..We aimed to determine the relative effects of alternative wound dressings on the healing of diabetic foot ulcers.
  76. ncbi Plantar tissue thickness is related to peak plantar pressure in the high-risk diabetic foot
    F Abouaesha
    Department of Medicine, Manchester Royal Infirmary, University of Manchester, Manchester, UK
    Diabetes Care 24:1270-4. 2001
    ....
  77. doi Systematic review of the effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers
    Rui Liu
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Mayo Clin Proc 88:166-75. 2013
    To assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature.
  78. doi The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells: a pilot study
    Seung Kyu Han
    Department of Plastic Surgery, Diabetic Wound Center, Korea University Guro Hospital, Seoul, Korea
    Wound Repair Regen 18:342-8. 2010
    ..In a subsequent clinical study, 26 patients with diabetic foot ulcers were treated using PLA cell autografts. Control treatment was also performed in 26 patients...
  79. pmc Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients
    Kanhaiya Singh
    Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India
    Biomed Res Int 2013:318686. 2013
    ..SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM)...
  80. pmc The neuropathic diabetic foot ulcer microbiome is associated with clinical factors
    Sue E Gardner
    University of Iowa, College of Nursing, Iowa City, Iowa, USA
    Diabetes 62:923-30. 2013
    Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes...
  81. doi Risk factors for lower extremity amputation in diabetic foot disease categorized by Wagner classification
    Jui Hung Sun
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 5 Fusing St, Gueishan Township, Taoyuan County 333, Taiwan, ROC
    Diabetes Res Clin Pract 95:358-63. 2012
    To elucidate the risk factors for lower extremity amputation (LEA) in patients of diabetic foot disease with different Wagner gradings.
  82. doi Effect of WF10 (immunokine) on diabetic foot ulcer therapy: a double-blind, randomized, placebo-controlled trial
    Narongchai Yingsakmongkol
    Department of Surgery, Faculty of Medicine, Srinakharinwirot University, Nakorn Nayok, Thailand
    J Foot Ankle Surg 50:635-40. 2011
    ..trial was undertaken to evaluate the effect of WF10 (Immunokine) as an adjunct to the standard treatment of diabetic foot ulcer. A total of 40 participants were randomized into 2 groups of 20...
  83. ncbi Diabetic foot infections: microbiology made modern? Array of hope
    Benjamin A Lipsky
    Diabetes Care 30:2171-2. 2007
  84. ncbi A review of the biomechanics of the diabetic foot
    C H M van Schie
    Department of Rehabilitation, University of Amsterdam, The Netherlands
    Int J Low Extrem Wounds 4:160-70. 2005
    In general, diabetic foot ulcers result from abnormal mechanical loading of the foot, such as repetitive moderate pressure applied to the plantar aspect of the foot while walking...
  85. pmc Evaluation of diabetic foot ulcer healing with hyperspectral imaging of oxyhemoglobin and deoxyhemoglobin
    Aksone Nouvong
    Olive View University of California Los Angeles Medical Center, Sylmar, California, USA
    Diabetes Care 32:2056-61. 2009
    ..We tested a hyperspectral imaging technology that quantifies cutaneous tissue hemoglobin oxygenation and generated anatomically relevant tissue oxygenation maps to assess the healing potential of diabetic foot ulcers (DFUs).
  86. ncbi Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications
    Ralf Lobmann
    Department of Endocrinology and Metabolism, Magdeburg University Medical School, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Diabetes Care 28:461-71. 2005
  87. pmc Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior
    Corey M Stanley
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Periodontol 79:861-75. 2008
    ..The biologic effects of FN fragments on wound healing remain unresolved. This study characterized the pattern of FN fragmentation and its effects on cellular behavior compared to intact FN...
  88. pmc Long-term prognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade
    Stephan Morbach
    Department of Diabetes and Angiology, Marienkrankenhaus, SOEST, Germany
    Diabetes Care 35:2021-7. 2012
    There is a dearth of long-term data regarding patient and limb survival in patients with diabetic foot ulcers (DFUs)...
  89. ncbi Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial
    Peter A Blume
    North American Center for Limb Preservation, 506 Blake St, New Haven, CT 06515, USA
    Diabetes Care 31:631-6. 2008
    ..The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients...
  90. ncbi Midfoot amputations expand limb salvage rates for diabetic foot infections
    Patrick A Stone
    Division of Vascular and Endovascular Surgery, University of South Florida, Tampa, FL 33606, USA
    Ann Vasc Surg 19:805-11. 2005
    ..Transtarsal amputations salvaged over half of nonhealing TMAs with excellent functional results...
  91. pmc Foot small muscle atrophy is present before the detection of clinical neuropathy
    Robert L Greenman
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Rd, Boston, MA 02115, USA
    Diabetes Care 28:1425-30. 2005
    ....
  92. doi The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial
    Francesco Squadrito
    Departments of Clinical and Experimental Medicine F S, A B, V A, G P, C S, L M, A s, M V, D C, Paediatric, Gynaecological, Microbiological, and Biomedical Sciences D A, and Experimental Surgical Sciences and Dentistry G D C, University of Messina, 98125 Messina, Italy Diabetology Unit E D F, Cardarelli Hospital, 80131 Naples, Italy and Department of Internal Medicine S C, University of Palermo, 90128 Palermo, Italy
    J Clin Endocrinol Metab 99:E746-53. 2014
    ..Foot ulcer is the principal cause of hospitalization for patients with diabetes. Polydeoxyribonucleotide (PDRN), an adenosine A2A receptor agonist, improves wound healing in diabetic mice...
  93. pmc The Charcot foot in diabetes
    Lee C Rogers
    Valley Presbyterian Hospital, Los Angeles, CA, USA
    Diabetes Care 34:2123-9. 2011
    ....
  94. doi How reliable are cultures of specimens from superficial swabs compared with those of deep tissue in patients with diabetic foot ulcers?
    Mesut Mutluoglu
    Department of Underwater and Hyperbaric Medicine, GATA Haydarpasa Teaching Hospital, 34668, Uskudar, Istanbul, Turkey
    J Diabetes Complications 26:225-9. 2012
    To assess the reliability of cultures of superficial swabs (SS) by comparing them with cultures of concomitantly obtained deep tissue (DT) specimens in patients with diabetic foot ulcers.
  95. doi Depression predicts first but not recurrent diabetic foot ulcers
    J S Gonzalez
    Ferkauf Graduate School of Psychology, Yeshiva University, Rousso Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Diabetologia 53:2241-8. 2010
    This study examined the relationship between symptoms of depression and the development of diabetic foot ulcers.
  96. doi Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation
    P van Battum
    Division of Endocrinology, Department of Medicine, Maastricht University Medical Centre, P Debyelaan 25, Maastricht, The Netherlands
    Diabet Med 28:199-205. 2011
    ..We evaluated minor amputation rate, the determinants of minor amputation and differences in amputation rate between European centres...
  97. ncbi Predictive value of foot pressure assessment as part of a population-based diabetes disease management program
    Lawrence A Lavery
    Diabetex Research Group, Baltimore, Maryland, USA
    Diabetes Care 26:1069-73. 2003
    ..In choosing the cut point, we looked for an optimum combination of sensitivity and specificity of plantar pressure to screen for neuropathic ulceration...
  98. doi Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration
    Ariadna Mendoza-Naranjo
    Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Cell Biol Int 36:661-7. 2012
    Poor healing of DFUs (diabetic foot ulcers) is a major clinical problem that can be extremely debilitating and lead to lower limb amputation...
  99. pmc Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes
    David J Margolis
    Department of Biostatistics and Epidemiology and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Diabetes Care 34:2363-7. 2011
    ..S. overall, neighboring locations have unexpectedly similar amputation rates, some being uniformly high and others uniformly low...
  100. ncbi The costs of diabetic foot: the economic case for the limb salvage team
    Vickie R Driver
    Department of Surgery, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    J Am Podiatr Med Assoc 100:335-41. 2010
    ..Although the team approach to diabetic foot problems is effective in preventing lower-extremity amputations, the costs associated with implementing a ..
  101. ncbi Neurogenic factors in the impaired healing of diabetic foot ulcers
    Hanna Galkowska
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    J Surg Res 134:252-8. 2006
    We hypothesize that the reduced innervation of skin can be observed both in clinically neuropathic and non-neuropathic diabetic foot ulcers and can contribute to low inflammatory cell infiltration.

Research Grants70

  1. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    ..Wound Electronic Medical Record (OWEMR) as a clinical intervention tool reduces amputations resulting from diabetic foot ulcers (DFUs) in a variety of healthcare settings...
  2. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..As many as 15% of patients with diabetes will suffer from a diabetic foot ulcer and, of these patients, 6% will be hospitalized due to infection or other ulcer-related complications...
  3. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..b>Diabetic foot complications account for the majority of lower limb amputations in the world, and 25% of all diabetic ..
  4. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..b>Diabetic foot ulcers cost tens of thousands of dollars to treat and are the leading cause of lower extremity amputation...
  5. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..Untreated diabetic foot ulceration and subsequent amputation has a profound impact on the quality of life of the diabetic patient...
  6. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..Treating a single diabetic foot wound costs up to $28,000 within a 24-month period...
  7. Transdermal Delivery of Deferoxamine to Prevent and Treat Diabetic Wounds
    Geoffrey C Gurtner; Fiscal Year: 2011
    ..b>Diabetic foot ulcers represent one of the most common sequelae of diabetes-associated dysfunction in new blood vessel growth...
  8. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2013
    ..b>Diabetic foot ulcers (DFUs) are one of the major complications of diabetes mellitus leadin to lower extremity amputation for ..
  9. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..b>Diabetic foot ulcers have an increased risk of infection due to the slow healing times caused by poor blood circulation in ..
  10. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    MARJANA contact TOMIC CANIC; Fiscal Year: 2010
    ..is to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs)...
  11. A comparative efficacy study: treatments of non-healing diabetic foot ulcers
    Roslyn R Isseroff; Fiscal Year: 2013
    ..The resulting diabetic foot ulcers (DFU) and subsequent amputations generate significant patient morbidity and millions of dollars of ..
  12. Molecular basis of Pseudomonas aeruginosa persistence in chronic wound infections
    Soyeon Lippman; Fiscal Year: 2013
    ..P. aeruginosa is a key causative agent for chronic wound infections, particularly in diabetic foot ulcers...
  13. Clinical Research Center to Decrease Limb Amputation Rate in People with Diabetes
    Harold Brem; Fiscal Year: 2013
    ..the candidate's research program is to reduce lower-limb amputations resulting from chronic non-healing diabetic foot ulcers (DFUs)...
  14. Mechanisms of Neuropeptides Action in Diabetes
    JANICE ZABOLOTNY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Peripheral neuropathy plays a major role in the development of diabetic foot ulceration (DFU) because of the pain insensitivity that allows prolonged tissue injury till a chronic wound has been ..
  15. Interactive Sensor Technology to Measure Adherence to Prescribed Therapeutic Foot
    Bor Rong Chen; Fiscal Year: 2012
    ..Cast Walkers, are used to reduce harmful pressures on the bottom of the foot for prevention and treatment of diabetic foot ulceration (DFU)...
  16. eukaryotic expression vectors resistant to transgene silencing
    James Williams; Fiscal Year: 2012
    ..gene therapy platform is applied to create a hypoxia-inducible factor 11 (HIF-11) based gene medicine for diabetic foot ulcer treatment...
  17. Development of an Antimicrobial Cellular Therapeutic for Inhibition of Biofilm Fo
    ALLEN R COMER; Fiscal Year: 2013
    ..As of 2006, infections of diabetic foot ulcers resulted in 82,000 amputations each year and it has been estimated that these numbers will increase by ..
  18. TP508: A New Drug for Mitigating Lethal Effects of Radiatin Exposure
    Laurie E Sower; Fiscal Year: 2013
    ..We proposed that TP508 (rousalatide acetate), a novel peptide drug currently in clinical trials for healing diabetic foot ulcers and fractures, may prevent RCI-induced mortality based on its acceleration of wound healing and its ..
  19. Altered gamma delta T cell-keratinocyte interplay in the skin of diabetic mice
    Julie M Jameson; Fiscal Year: 2013
    b>Diabetic foot ulcerations are a debilitating complication common to type 1 and 2 diabetes...
  20. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2010
    ..5 to 4.5 million will develop a chronic wound in their lifetime. The overall cost of diabetic foot problems, including loss of productivity, could be as high as $20 billion per year...
  21. Role of Neuropeptides in Diabetic Foot Problems
    Aristidis Veves; Fiscal Year: 2013
    ..Impaired wound healing is an important clinical problem in diabetes resulting in failure to completely heal diabetic foot ulcers and more that 75,000 lower extremity amputations annually...
  22. TAS::75 0849::TAS
    Barbara Olszewska-Pazdrak; Fiscal Year: 2011
    ..TP508 has shown positive results in diabetic foot ulcer and fracture repair trials without adverse effects...
  23. iPSC-derived Repair-Responsive Fibroblasts to Heal Diabetic Foot Ulcers
    Jonathan A Garlick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic foot ulceration (DFU) is a major problem that significantly impairs quality of life of the patient, leads to prolonged hospitalizations and may require major amputation, demonstrating the ..
  24. Image Guidance Method for Diabetic Foot Surgery
    IRVING WEINBERG; Fiscal Year: 2010
    ..Providing additional confidence might allow surgeons and podiatrists to be more conservative in their resections, thereby improving patients'quality of life. ..
  25. Antimicrobial Hydrogels for Prevention of Surgical Site Infections (SSIs)
    Diego Benitez; Fiscal Year: 2012
    ..hydrogel product may also help prevent infections in traumatic wounds and chronic wounds such as diabetic foot ulcers...
  26. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute and chronic wounds such as diabetic foot ulcers represent a major area of medical concern...
  27. Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air
    Aristidis Veves; Fiscal Year: 2013
    ..provided by applicant): Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air Diabetic foot ulcers (DFUs) are a frequent and debilitating complication of diabetes, and affect 1-2...
  28. Engineering NRG Signaling For Therapeutic Vascularization In Diabetic Wounds
    STEVEN MICHAEL JAY; Fiscal Year: 2013
    ..receptors is a novel, promising approach to decreasing morbidity and mortality associated with non-healing diabetic foot ulcers...
  29. Engineering NRG Signaling For Therapeutic Vascularization In Diabetic Wounds
    STEVEN MICHAEL JAY; Fiscal Year: 2013
    ..receptors is a novel, promising approach to decreasing morbidity and mortality associated with non-healing diabetic foot ulcers...
  30. MiniPlasmid vector platform for non-viral gene therapy
    James Williams; Fiscal Year: 2013
    ..A hypoxia- inducible factor 1[unreadable] (HIF-1 [unreadable]) based gene medicine for diabetic foot ulcer treatment is developed utilizing an extended half-life oxygen resistant highly active HIF-1 [unreadable] ..
  31. Microvascular Functional Imaging System
    PETER SOLIZ SOLIZ; Fiscal Year: 2011
    ..disease, kidney disease (nephropathy), ocular diseases (diabetic retinopathy), and peripheral neuropathy (diabetic foot). Two million diabetics will develop a foot ulcer during their lifetime...
  32. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    ..of dead, damaged and/or infected tissue from thermal burn wounds and a certain subset of ischemic and necrotic diabetic foot wounds is a commonly utilized wound preparation modality before the application of fillers, dressings or ..
  33. Enhancing diabetic foot education by viewing personal plantar pressures
    Jinsup Song; Fiscal Year: 2012
    ..interest in foot-type biomechanics, footwear design, and other conservative interventions ultimately to reduce diabetic foot complications. Over time, Dr. Song recognized the inadequacy of the current diabetic foot care education...
  34. Investigation of Plantar Shear Stresses in Diabetic Patients: Relevance to Foot U
    Metin Yavuz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Diabetic foot ulcers continue to burden US healthcare system with an annual cost of $11 billion and yearly amputation rates of 100,000...
  35. Diabetic Foot Imaging Scanner(DFIS)
    JEFFREY NORMAN SCHOESS; Fiscal Year: 2013
    ..is pleased to submit this revised Phase 2 SBIR proposal to develop the infrared "Diabetic Foot Imaging Scanner (DFIS)" to demonstrate the ability to capture dynamic thermal imagery and identify hot spots ..
  36. Nonvisual Foot Examination for People with Diabetes and Visual Impairment
    Ann S Williams; Fiscal Year: 2012
    ..The potential downstream impact is reduced costs of care for diabetes complications on the population level. For every 1% reduction in diabetic foot complications, costs would be reduced by $137 million.
  37. Vertical and shear forces and distributions in the diabetic foot
    Scott Barnes; Fiscal Year: 2012
    ..to biomechanists, podiatrists, physical therapists, and doctors specializing in the treatment of diabetes and diabetic foot complications...
  38. Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes
    David J Vachon; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Diabetic foot ulcers are a common type of chronic wound affecting as many as 25% of all diabetics and in many cases ..
  39. Novel Therapeutic Approaches for the Management of Diebetic Foot Ulceration
    Aristidis Veves; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Diabetic foot ulceration (DFU) and associated impairedhealing, is a major problem that significantly impairs the quality of life of diabetic patients, leading to prolonged hospitalization and ..
  40. DIABETIC FOOT ULCER DEVICE
    PAUL BUREK; Fiscal Year: 2000
    b>Diabetic foot ulcers account for 55,000 amputations per year and are the leading cause of diabetic patient hospitalizations...
  41. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..5 million Americans annually, particularly the elderly. Diseases within this family include diabetic foot ulcers, venous stasis ulcers, and pressure ulcers...
  42. Stem cell mobilization and diabetic skin ulcers
    STEPHEN RAYMOND THOM; Fiscal Year: 2013
    ..Our hypothesis is that an analysis of SPCs number and their biochemical characteristics can predict whether diabetic foot ulcers will heal...
  43. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..determine the efficacy of FDG-PET imaging in the diagnosis of osteomyelitis or deep infection in patients with diabetic foot in a large patient population...
  44. TGF-BETA FOR PLEURODESIS
    Kirk Lane; Fiscal Year: 2000
    ..The therapeutic use of TGF-beta is currently being explored for diabetic foot ulcers in phase II/III trials. Pleurodesis would be a new indication for this compound...
  45. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, ..
  46. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  47. The Development and Testing of a Sonic Treatment Brush for Diabetic Foot Ulcers
    ROBERT AKRIDGE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Non-healing diabetic foot ulcers are potentially a limb- and life-threatening complication of chronic diabetes mellitus and associated peripheral neuropathy...
  48. Clinical Testing of Hyperspectral Assessment & Prediction of Diabetic Foot Ulcers
    KEVIN SCHOMACKER; Fiscal Year: 2007
    ..We believe FHSI can have positive impact on quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs. ..
  49. Topical Salicylanilides to Treat Diabetic Foot Ulcer
    Joseph Dunn; Fiscal Year: 2002
    ..class of patented, Lipophilic, Antimicrobial, Anti-inflammatory Drugs (LAADs) for the treatment of Diabetic Foot Ulcer (DFU)...
  50. Circumferential Neuropathic Foot Protector System (CNEP)
    Jeffrey Jensen; Fiscal Year: 2001
    b>Diabetic foot complications result in over 67,000 lower extremity amputations annually and cause more hospitalizations than any other single complication of diabetes...
  51. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..A large proportion of patients with chronic wounds, such as diabetic foot ulcers, and venous leg ulcers, are unresponsive to conventional treatment, such as moist dressings...
  52. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    ANTON LEWIS USALA; Fiscal Year: 2000
    Progression of diabetic foot ulcers is the leading cause of lower limb amputation in the U.S...
  53. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2003
    ..blood, endocardium, genitourinary tract, abdomen, wounds, and skin and soft tissue (burns, decubitis ulcers, diabetic foot ulcers). Preliminary studies in this laboratory have demonstrated that at least two E...
  54. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..The estimated annual cost of $9 billion doesn't include the pam, suffering, and morbidity of diabetic foot ulcers...
  55. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2003
    ..project grant (R01) is to develop a comprehensive understanding of the biophysical factors determining diabetic foot ulcer healing. Approximately 16 million Americans are known to have diabetes...
  56. Innovative intervention for healing of diabetic ulcers
    Joyce Stechmiller; Fiscal Year: 2005
    ..this study is: (1) to determine the effectiveness of topical doxycycline to accelerate the healing of chronic diabetic foot ulcers, (2) describe the molecular changes that occur in diabetic foot ulcers as they heal and (3) detect ..
  57. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    Ronald Hill; Fiscal Year: 2005
    Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27...
  58. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2007
    ..These studies should provide new insights into the mechanism by which adenosine A2A receptor agonists, a novel therapy undergoing clinical trials for wound healing of diabetic foot ulcers, promote wound healing.
  59. Diabetic Foot Ulcer Healing by Load Relieving Dressings
    Joseph Loomis; Fiscal Year: 2006
    ..abstract_text> ..
  60. OSTEOMYELITIS THERAPY MONITORED BY ANTIBODIES, WBC & MRI
    Donald Schauwecker; Fiscal Year: 1993
    Osteomyelitis commonly occurs as a complication of bone surgery, open fracture, diabetic foot ulcer, penetrating wound, or similar condition...
  61. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2009
    ..Wounds that fail to heal, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are a major source of morbidity, mortality, and health care ..
  62. Diabetes Initiative for Applied Biomedical Engineering
    Brian Davis; Fiscal Year: 2007
    ..g., cardiovascular disease, diabetic foot pathologies, and peripheral vascular disease...
  63. Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
    Paul Hamilton; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary/Abstract: Diabetic foot ulcers are a significant health problem that imposes high costs on both patients and society (Boulton, Vileikyte et al. 2005)...
  64. Novel Cation-Exchange Wound Dressing for Diabetic Ulcers
    DAVID VACHON; Fiscal Year: 2004
    ..million people in the United States have diabetes and more than two million of these individuals will develop diabetic foot ulcers during their lifetime...
  65. Hyperspectral Imaging to Predict and Assess Foot Ulcers
    Jenny Freeman; Fiscal Year: 2004
    ..Our long-term objectives are to reduce the frequency of diabetic foot ulcers (DFU) & decrease the amputation rate in Type 1 diabetics by developing Hyperspectral Imaging for ..
  66. Depression, foot ulcer, and incident amputation in veterans with diabetes
    Lisa Williams; Fiscal Year: 2009
    ..Poor self-care may adversely affect the management of diabetic foot ulcers, the major factor leading to 85,000 amputations annually in the U.S...
  67. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..In the majority of diabetic subjects, the underlying factor which contributes to eventual amputation is the diabetic foot ulcer...
  68. Mapping the Mechanical Properties of the Diabetic Foot
    John Weaver; Fiscal Year: 2006
    ..abstract_text> ..
  69. Skin Interface Friction Transducer
    JEFFREY SCHOESS; Fiscal Year: 2003
    ..is 15 to 46 times higher in diabetics than persons without diabetic mellitus, with the vast majority of diabetic foot complications resulting in amputation due to formation of skin ulcers...
  70. Diabetic Foot Ulcer Healing by Load Relieving Dressing
    Joseph Loomis; Fiscal Year: 2002
    ..abstract_text> ..