Genomes and Genes
Summary: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
Publications346 found, 100 shown here
- Is it possible to treat vascular dementia?Dina Zekry
Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thonex, Geneva, Switzerland
Front Neurol Neurosci 24:95-106. 2009Randomized controlled trials of primary and secondary prevention of vascular dementia demonstrate real effects on the cause or progression of disease (disease-modifying treatment)...
- Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and ADN Schuff
Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
Neurology 61:358-64. 20031) To determine the regional pattern of reduced N-acetylaspartate (NAA) in subcortical ischemic vascular dementia (SIVD); 2) to explore the relationship between NAA reduction and subcortical vascular disease; and 3) to test if MR ..
- Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementiaGuizhi Zhang
Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China
J Ethnopharmacol 115:441-8. 2008..Ginsenosides, the major active ingredients of Panax ginseng, produce a variety of pharmacological or physiological responses with effects on the central and peripheral nervous systems...
- Subcortical ischaemic vascular dementiaGustavo C Roman
University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
Lancet Neurol 1:426-36. 2002b>Vascular dementia is the second most common type of dementia. The subcortical ischaemic form (SIVD) frequently causes cognitive impairment and dementia in elderly people...
- The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads convergedSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
Arch Neurol 66:300-5. 2009..also proved difficult to distinguish in human patients, blurring the lines between Alzheimer disease and vascular dementia. This review highlights recent work aimed at identifying convergent mechanisms such as insulin resistance ..
- Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?T von Zglinicki
Institute of Pathology at the Evangelische Geriatriezentrum Berlin, Germany
Lab Invest 80:1739-47. 2000..However, specific risk factors for vascular dementia are still not known. Human telomeres shorten with each cell division in vitro and with donor age in vivo...
- The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementiaYounyoung Kim
Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
Stroke 37:2843-5. 2006..We investigated the association of the polymorphism in TGFB1 with ischemic stroke and vascular dementia.
- Vascular dementia prevention: a risk factor analysisGustavo C Roman
Department of Medicine Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
Cerebrovasc Dis 20:91-100. 2005..from ischemic or hemorrhagic cerebrovascular disease (CVD) produces decline in cognitive functions and vascular dementia (VaD). Likewise, CVD may cause VaD from hypoperfusion of susceptible brain areas...
- Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementiaElisabeth Tarkowski
Department of Rheumatology, University of Goteborg, Goteborg, Sweden
Neurobiol Aging 23:237-43. 2002The aim of the present study was to investigate, in patients with Alzheimer's disease (AD), and vascular dementia (VAD), patterns of local release of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta)..
- Towards defining the neuropathological substrates of vascular dementiaRaj N Kalaria
Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
J Neurol Sci 226:75-80. 2004Cerebrovascular disease is highly heterogeneous but can culminate in vascular cognitive impairment or vascular dementia (VaD)...
- Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementiaYoko Okamoto
Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Neuroreport 20:990-6. 2009Cortical microinfarcts are reported in Alzheimer's disease, but not in subcortical vascular dementia; the disease specificity of cortical microinfarcts therefore remains unclear...
- The restoration after repetitive transcranial magnetic stimulation treatment on cognitive ability of vascular dementia rats and its impacts on synaptic plasticity in hippocampal CA1 areaFei Wang
Department of Neurology, General Hospital, Tianjin Medical University, Tianjin, People s Republic of China
J Mol Neurosci 41:145-55. 2010The purposes of this research were to study the restoration on the cognitive ability of rat models with vascular dementia (VaD) by repetitive transcranial magnetic stimulation (rTMS) treatment and its impacts on synaptic plasticity in ..
- Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampusA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Neurology 58:1635-41. 2002To determine the effects of subcortical ischemic vascular dementia (SIVD) and AD on entorhinal cortex (ERC) and hippocampus.
- Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia?Marta Grau-Olivares
Cerebrovascular Division, Department of Neurology, Hospital Universitari del Sagrat Cor, Universitat de Barcelona, E 08029 Barcelona, Spain
Expert Rev Neurother 9:1201-17. 2009..Ischemic cerebral small-vessel disease should be regarded as a potentially severe condition prodrome of subcortical vascular dementia rather than a relatively benign disorder.
- Oxidative stress in vascular dementia and Alzheimer's disease: a common pathologyStuart Bennett
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK
J Alzheimers Dis 17:245-57. 2009Alzheimer's disease and vascular dementia are the two most common types of dementia with the former being the most predominant...
- Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imagingS Mackay
Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, USA
Arch Neurol 53:167-74. 1996..creatine plus phosphocreatine [Cr]) in subjects with Alzheimer's disease (AD), with subcortical ischemic vascular dementia (SIVD), and elderly controls. DESIGN: Cross-sectional, between groups...
- Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementiaP H Yu
Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Med Hypotheses 57:175-9. 2001..Formaldehyde may cause cytotoxicity, which induces inflammation and release of more SSAO, producing a cascade of toxic cycle. Increased SSAO-mediated reaction may be chronically involved in the pathogenesis of vascular dementia and AD.
- CSF biomarker profile and diagnostic value in vascular dementiaG P Paraskevas
Department of Neurology, School of Medicine, Athens National University, Athens, Greece
Eur J Neurol 16:205-11. 2009The differential diagnosis between vascular dementia (VD) and Alzheimer's disease (AD) or mixed dementia (MD) is not always easy in clinical practice...
- The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementiaKelly Davis Garrett
Department of Psychiatry and Human Behavior, Brown Medical School, USA
Arch Clin Neuropsychol 19:745-57. 2004..individuals at risk for cerebrovascular disease (R-CVD), 18 individuals with VaCIND, and 26 individuals with vascular dementia (VaD) were examined to determine whether patterns of neuropsychological assessment performance can assist in ..
- MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementiaR Barber
Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
Neurology 54:1304-9. 2000To compare global and regional atrophy on MRI in subjects with dementia with Lewy bodies (DLB), AD, vascular dementia (VaD), and normal aging...
- Vascular and biochemical risk factors of vascular dementia after lacunar strokes (S-VaD) and after multiinfarcts in strategic areas (M-VaD)Ałła Graban
First Department of Neurology and Institute of Psychiatry and Neurology, Warsaw, Poland
J Neurol Sci 283:116-8. 2009..Ischemic lesions in the brain have an influence on the natural history of dementia. Vascular dementia can be caused by small-vessels disease (S-VaD) or by large-artery atherosclerosis with vascular lesions in ..
- Body mass index in midlife and risk of Alzheimer disease and vascular dementiaRachel A Whitmer
Kaiser Permanente Division of Research, Etiology and Prevention, 2000 Broadway, Oakland, CA 94612, USA
Curr Alzheimer Res 4:103-9. 2007..It is unknown if there is a difference in the risk of developing Alzheimer disease (AD) versus vascular dementia (VaD) associated with high body weight...
- Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
- Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama StudyA Sekita
Department of Environmental Medicine, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka City, Japan
Acta Psychiatr Scand 122:319-25. 2010To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population.
- Risk factors for vascular dementia and Alzheimer diseasePhilip B Gorelick
Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 South Wood St, Room 855N, Chicago, IL 60612, USA
Stroke 35:2620-2. 2004..We review vascular factors that might be responsible to cognitive decline in Alzheimer disease and vascular cognitive impairment and the corresponding interventions that might prevent cognitive impairment as we age...
- The enigma of vascular cognitive disorder and vascular dementiaKurt A Jellinger
Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
Acta Neuropathol 113:349-88. 2007The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed vascular cognitive impairment, are a matter of discussion, and currently used clinical diagnostic criteria show moderate sensitivity (average 50%) ..
- Similarities between Alzheimer's disease and vascular dementiaRaj Kalaria
Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
J Neurol Sci 203:29-34. 2002Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common forms of dementia. In Europe, 800,000 people have a diagnosis of VaD out of 3.7 million people with clinical dementia...
- Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementiaMarieke van Oijen
Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Stroke 36:2637-41. 2005..Both fibrinogen and C-reactive protein are considered inflammatory markers. Fibrinogen also has important hemostatic properties. We investigated the association of fibrinogen and C-reactive protein with dementia...
- Vascular dementia in a population-based autopsy studyDavid S Knopman
Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Arch Neurol 60:569-75. 2003The validity of the clinical diagnosis of vascular dementia (VaD) remains suboptimal.
- Brain hypoperfusion: a critical factor in vascular dementiaGustavo C Roman
University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
Neurol Res 26:454-8. 2004Subcortical ischemic vascular dementia is a relatively common form of dementia. Anatomical changes of ageing in the brain arteries predispose the elderly to the effects of hypotension...
- Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and ChengduZhen Xin Zhang
Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Arch Neurol 62:447-53. 2005Prevalences of Alzheimer disease (AD) and vascular dementia (VaD) in China reportedly differ from those in Western countries.
- Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementiaChie Yasutake
Department of Neuropsychiatry, Osaka Medical College, Daigakumachi 2 7, Takatsuki, Osaka, Japan
Eur Arch Psychiatry Clin Neurosci 256:402-6. 2006..The following subjects were included in this study: 60 AD patients, 60 vascular dementia (VaD) patients and 33 healthy controls...
- Prevalence, resource utilization and costs of vascular dementia compared to Alzheimer's dementia in a population settingA Sicras
Badalona Serveis Assistencials SL, Badalona, Barcelona, Spain
Dement Geriatr Cogn Disord 19:305-15. 2005To determine the prevalence of dementia and to measure the monetary impact and health resources utilization of vascular dementia (VD) compared to Alzheimer's dementia (AD) in persons aged over 64 years in a population setting.
- Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementiaH Lewis
Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Essex
Neuropathol Appl Neurobiol 32:103-18. 2006Clinicopathological observations suggest there is considerable overlap between vascular dementia (VaD) and Alzheimer's disease (AD)...
- Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementiaM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
Dement Geriatr Cogn Disord 18:265-70. 2004..regarding the simultaneous behavior of peripheral antioxidants and biomarkers of oxidative stress in AD and vascular dementia (VaD). Sixty-three AD patients, 23 VaD patients and 55 controls were included in the study...
- Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic studyS Ahtiluoto
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Neurology 75:1195-202. 2010To investigate the relation of diabetes to dementia, Alzheimer disease (AD), and vascular dementia (VaD), through analyses of incidence, mortality, and neuropathologic outcomes in a prospective population-based study of the oldest old.
- Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imagingNorbert Schuff
Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
Alzheimers Dement 5:454-62. 2009Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, ..
- Vascular compliance is reduced in vascular dementia and not in Alzheimer's diseaseSasha Dhoat
Faculty of Medicine, Imperial College, London, UK
Age Ageing 37:653-9. 2008to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD).
- Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementiaH K Wang
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
J Neural Transm (Vienna) 113:1499-509. 2006Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD)...
- Effect of acupuncture treatment on vascular dementiaJianchun Yu
Gerontological Department, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Neurol Res 28:97-103. 2006Recent studies have suggested that acupuncture can ameliorate some symptoms commonly associated with vascular dementia (VaD)...
- 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysisNacer Kerrouche
INSERM U320, University of Caen, Caen, France
J Cereb Blood Flow Metab 26:1213-21. 2006The brain metabolic pattern of vascular dementia (VaD) remains poorly characterized. Univariate voxel-based analysis ignores the functional correlations among structures and may lack sensitivity and specificity...
- Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging StudyDanielle Laurin
Neuroepidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Am J Epidemiol 159:959-67. 2004..disease, 38 cases of Alzheimer's disease with contributing cerebrovascular disease, and 44 cases of vascular dementia)...
- Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's diseaseAndrea Flex
Istituto di Medicina Interna e Geriatria, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, L go A Gemelli 8, 00168 Rome, Italy
J Gerontol A Biol Sci Med Sci 61:1065-9. 2006b>Vascular dementia (VAD) and Alzheimer's disease (AD) may share common neuropathological mechanisms. Matrix metalloproteinases (MMPs) may induce destruction of the extracellular matrix, neuronal dysfunction, and death...
- Acupuncture increases cerebral glucose metabolism in human vascular dementiaYong Huang
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Int J Neurosci 117:1029-37. 2007Recent studies indicate beneficial effects of acupuncture in the rehabilitation of vascular dementia (VaD)...
- Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementiaYoshiyuki Ban
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
Atherosclerosis 195:153-9. 2007..The present study aims at evaluating the relationship between plasma levels of 5-HT and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease...
- Childhood cognitive ability and risk of late-onset Alzheimer and vascular dementiaBrian McGurn
Geriatric Medicine Unit, University of Edinburgh, UK
Neurology 71:1051-6. 2008..We investigated differential effects of premorbid cognitive ability on dementia subtypes to clarify which causal pathway was predominant...
- Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementiaL M Allan
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, London, UK
Dement Geriatr Cogn Disord 19:140-4. 2005..HRV has not been studied in vascular dementia (VAD). We investigate autonomic function in AD and VAD, using power spectral analysis of HRV...
- Subcortical vascular dementia: integrating neuropsychological and neuroradiologic dataC C Price
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Neurology 65:376-82. 2005Research criteria for subcortical vascular dementia are based on radiologic evidence of vascular pathology and greater impairment on tests of executive control than memory...
- Status of risk factors for vascular dementiaI Skoog
Institute of Clinical Neuroscience, Sahlgrenska Hospital, Goteborg University, Sweden
Neuroepidemiology 17:2-9. 1998The two most common causes of vascular dementia (VAD) are dementia evolving in connection with multiple small or large strokes and dementia related to ischemic white-matter lesions (WMLs) of the brain...
- Validity of the clinical diagnostic criteria for vascular dementia: a critical review. Part IISandra Wiederkehr
Ecole de Psychologie, Universite Laval, Quebec, QC, G1V OA6, Canada
J Neuropsychiatry Clin Neurosci 20:162-77. 2008This review is the second of a two-part series focusing on the validity of eight clinical criteria for vascular dementia. Sixteen studies were selected according to their purposes and quality of experimental design...
- The role of brain infarcts and hippocampal atrophy in subcortical ischaemic vascular dementiaG Gainotti
Institute of Neurology, Catholic University, Policlinico Gemelli, Largo A Gemelli 8, I 00168 Rome, Italy
Neurol Sci 25:192-7. 2004..A total of 39 patients multiple subcortical infarcts, who could be considered as possible vascular dementia with small vessel pathology, with underwent a neuropsychological study and brain magnetic resonance imaging (..
- Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in BraziliansD R S Souza
Departamento de Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, SP, Brasil
Braz J Med Biol Res 36:919-23. 2003....
- White matter damage is associated with matrix metalloproteinases in vascular dementiaG A Rosenberg
Department of Neurology, University of New Mexico, Albuquerque 87131, USA
Stroke 32:1162-8. 2001..multi-infarct dementia (MID) or Binswanger's disease (BD), the latter of which is a progressive form of vascular dementia (VaD) associated pathologically with fibrinoid and hyaline changes in brain arterioles with injury to the ..
- Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable?Jae Min Kim
Department of Psychiatry, College of Medicine, Chosun University, Kwangju, Republic of Korea
Hum Psychopharmacol 18:215-20. 2003..behavioral and psychological symptoms of dementia (BPSD) between patients with Alzheimer's disease (AD) and vascular dementia (VaD); (2) to investigate the differences in the correlates of BPSD between them; and (3) to suggest ..
- The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's diseaseC Ballard
Reader in Old Age Psychiatry, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 16:499-503. 2001..Little is known about the rate of progression or associations of cognitive impairment in dementia with Lewy bodies (DLB), or the associations of accelerated decline...
- Classification of vascular dementia in the Cardiovascular Health Study Cognition StudyO L Lopez
Departments of Neurology, University of Pittsburgh School of Medicine, PA, USA
Neurology 64:1539-47. 2005To describe the diagnostic classification of subjects with incident vascular dementia (VaD) participating in the Cardiovascular Health Study (CHS) Cognition Study.
- Metabolic alterations in the hypothalamus and basal forebrain in vascular dementiaTatjana A Ishunina
Netherlands Institute for Brain Research, Amsterdam
J Neuropathol Exp Neurol 63:1243-54. 2004..the present study we aimed at determining for the first time whether metabolic changes would also occur in vascular dementia (VD) patients in the supraoptic (SON), infundibular (INF), tuberomamillary (TMN), medial mamillary nuclei, ..
- The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementiaM Gawel
Department of Neurology, Medical University of Warsaw, Poland
J Neurol Sci 283:127-33. 2009..To investigate whether quantitative EEG may be useful in differential diagnosis of AD and SVD and to determine the correlation between dementia and abnormalities in EEG...
- Clinical significance of microbleeds in subcortical vascular dementiaSang Won Seo
Stroke 38:1949-51. 2007Despite many studies investigating the association between the ischemic changes and cognitive impairment in subcortical vascular dementia (SVaD), few studies correlated cognitive impairment with microbleeds (MBs) frequently seen in SVaD.
- Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementiaTakuya Watanabe
Third Department of Internal Medicine, Showa University School of Medicine, Division of Internal Medicine, Showa University Karasuyama Hospital, Tokyo, Japan
Metabolism 53:476-82. 2004b>Vascular dementia (VaD) and Alzheimer's disease (AD) are the most common causes of dementia in the elderly...
- Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementiaM P Walker
Medical Research Council Neurochemical Pathology Unit, Institute for the Health of the Elderly, Newcastle, UK
Neurology 54:1616-25. 2000..Case reports and clinical observations suggest that fluctuating cognition (FC) is common in the major dementias, particularly dementia with Lewy bodies (DLB), where it is one of three core clinical diagnostic features...
- Lipids' peroxidation markers in Alzheimer's disease and vascular dementiaKatarzyna Gustaw-Rothenberg
University Memory and Cognition Center, Neurological Institute, Case Western Reserve University, Beachwood, Ohio 44122, USA
Geriatr Gerontol Int 10:161-6. 2010..In this study, the level of various oxidative stress parameters were measured in AD, vascular dementia (VaD), and age- and sex-matched control patients...
- Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating CenterLawrence S Honig
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neurology 64:494-500. 2005..This investigation examined the association between cerebrovascular disease and the pathologic manifestations of AD in an autopsy series...
- Vascular dementia: clinical, neuroradiologic and neuropathologic aspectsM E Murray
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
Panminerva Med 49:197-207. 2007b>Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease (AD), and some studies suggest that the frequency increases exponentially over the age of 65 years...
- Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effectsS Engelborghs
Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
J Neurol Neurosurg Psychiatry 74:1148-51. 2003The authors conducted a prospective study of neurodegenerative and vascular dementia in Belgium. Strict diagnostic inclusion criteria were used to include well defined patients and controls...
- Comparative study of the specificities of needling acupoints DU20, DU26 and HT7 in intervening vascular dementia in different areas in the brain on the basis of scale assessment and cerebral functional imagingYong Huang
TCM College of Nanfang Medical University, Guangzhou, 510515, China
Chin J Integr Med 13:103-8. 2007..of clinical scale assessment and cerebral functional imaging to compare the relative specificity of needling acupoints Baihui (DU20), Shuigou (DU26) and Shenmen (HT7) in intervening vascular dementia (VD) in different areas in the brain.
- Progression of mild cognitive impairment to Alzheimer's or vascular dementia versus normative aging among elderly ChineseJuebin Huang
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Curr Alzheimer Res 2:571-8. 2005..evolutionary progressions from Mild Cognitive Impairment (MCI) to dementia of Alzheimer's type (DAT) or to vascular dementia (VaD) versus normal aging, subjects identified as MCI or as cognitively normal (CN) during standard ..
- Neuropsychiatric profiles of patients with Alzheimer's disease and vascular dementia in TaiwanChia Jung Hsieh
School of Geriatric Nursing and Care Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC
Int J Geriatr Psychiatry 24:570-7. 2009Previous studies have reported several conflicting findings regarding neuropsychiatric symptoms when comparing patients with Alzheimer's disease (AD) and patients with vascular dementia (VaD).
- Vascular dementia: prevention and treatmentCatherine McVeigh
Department of Geriatric Medicine, Faculty of Medicine and Health Sciences, Queen s University of Belfast, Belfast, Northern Ireland, UK
Clin Interv Aging 1:229-35. 2006b>Vascular dementia (VaD) is the most common cause of dementia in the elderly, second only to Alzheimer's disease (AD)...
- Vascular dementiaMichael J Schneck
Neurology and Neurosurgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA
Top Stroke Rehabil 15:22-6. 2008b>Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's dementia (AD)...
- Behavioral alterations and vascular dementiaRita Moretti
Dipartimento di Fisiologia e Patologia, Ambulatorio Disturbi Cognitivi, Universita degli Studi di Trieste, Trieste, Italy
Neurologist 12:43-7. 2006b>Vascular dementia is one of the most frequent forms of dementia, where behavioral and cognitive symptoms coexist...
- Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementiaJ T O'Brien
Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Neurology 56:1386-8. 2001..boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20)...
- A mouse model characterizing features of vascular dementia with hippocampal atrophyKeiko Nishio
Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
Stroke 41:1278-84. 2010..circuit damage without apparent gray matter changes, indicating similarities with subcortical ischemic vascular dementia. However, as subcortical ischemic vascular dementia progresses over time, the longer-term effects that ..
- Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementiaG Zuliani
Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Italy
J Neurol Sci 272:164-70. 2008..60) or vascular dementia (VD: n. 80)...
- A review of the epidemiological transition in dementia--cross-national comparisons of the indices related to Alzheimer's disease and vascular dementiaG H Suh
Department of Psychiatry, Hallym University College of Medicine, Hangang Sacred Heart Hospital, Seoul, Korea
Acta Psychiatr Scand 104:4-11. 2001..RESULTS: Alzheimer's disease (AD) has become nearly twice as prevalent as vascular dementia (VaD) in Korea, Japan, and China since transition in early 1990s...
- Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese populationT Yamada
Department of Internal Medicine and Health Care, Fukuoka University, School of Medicine, Japan
Psychiatry Clin Neurosci 55:21-5. 2001..8 for all types of dementia, 2.1 for Alzheimer's disease (AD), 1.0 for vascular dementia (VD) and 0.7 for other types of dementia...
- Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's typeK Mishima
Department of Neuropsychiatry, Akita University School of Medicine, Japan
Chronobiol Int 15:647-54. 1998..effect of morning bright and dim light exposure on rest-activity (R-A) rhythm disorders in patients with vascular dementia (VD) and patients with dementia of Alzheimer's type (DAT)...
- Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementiaYoshiyuki Ban
Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Tokyo 142 8555, Japan
J Atheroscler Thromb 16:179-87. 2009..The expression of UII and its receptor (UT) mRNA is detected at high levels in the brain. We evaluated the relationship between plasma UII levels and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease.
- Cytokines in Alzheimer's disease and vascular dementiaP Angelopoulos
General Hospital of Xanthi, Greece
Int J Neurosci 118:1659-72. 2008..significant correlation was recorded in the interleukin levels among patients with Alzheimer's disease and vascular dementia. Also, no significant correlation was observed in the interleukin levels in the serum and the severity of ..
- Subcortical ischemic vascular dementiaHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
Neurol Clin 25:717-40, vi. 2007Subcortical ischemic vascular dementia (SIVD) has been proposed as a subtype of vascular cognitive impairment. MRI often discloses "silent" hyperintensities in 20% to 40% of community-dwelling elderly...
- Subcortical vascular dementiaTimo Erkinjuntti
Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
Cerebrovasc Dis 13:58-60. 2002b>Vascular dementia (VaD) incorporates different vascular mechanisms and changes in the brain, and has different causes and clinical manifestations...
- Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementiaG Zuliani
Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, and Long Term Division, Ca Foncello Hospital, Treviso, Italy
J Psychiatr Res 41:686-93. 2007..A possible increase in plasma cytokines levels has been reported in LOAD and vascular dementia (VD), but the results of previous studies are conflicting...
- Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementiaD Bathgate
Department of Neurology, Manchester Royal Infirmary, UK
Acta Neurol Scand 103:367-78. 2001..CONCLUSIONS: Behavioural characteristics accurately differentiate FTD from AD and CvD. The findings highlight the particular importance of affective change in FTD, and underline the role of the frontotemporal lobes in emotion...
- Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern IrelandStephen P McIlroy
Department of Geriatric Medicine, Queen s University Belfast, Belfast, Northern Ireland
Stroke 33:2351-6. 2002..Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase (MTHFR) genotype...
- Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging StudyMichael H Freitag
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Stroke 37:33-7. 2006..This study explores whether this association is attributable to the pulsatile, ie, pulse pressure (PP), or the nonpulsatile component of blood pressure (BP)...
- Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophySalka S Staekenborg
Department of Neurology, Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Stroke 40:1269-74. 2009....
- Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trialsHarish Kavirajan
Department of General Internal Medicine, Division of Health Services Research, Veterans Affairs Greater Los Angeles Health Care System, CA, USA
Lancet Neurol 6:782-92. 2007Cholinesterase inhibitors and memantine do not have regulatory approval in most of the world for treatment of vascular dementia. A systematic review and meta-analysis was undertaken to assess the evidence for efficacy and safety of ..
- Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementiaR Squitti
Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Rome, Italy
Neurology 60:2013-4. 2003
- Elevated plasma fibrin D-dimer as a risk factor for vascular dementia: the Three-City cohort studyL Carcaillon
INSERM Unit 780, Cardiovascular Epidemiology, Villejuif
J Thromb Haemost 7:1972-8. 2009..However, few studies have investigated these associations in the elderly. Moreover, vascular factors may be involved in dementia. Data on the relationship between hemostatic biomarkers and dementia remain scarce...
- Relation of plasma lipids to Alzheimer disease and vascular dementiaChristiane Reitz
Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Arch Neurol 61:705-14. 2004The relation between plasma lipid levels and Alzheimer disease (AD) and vascular dementia (VaD), and the impact of drugs to lower lipid levels remains unclear.
- Autonomic dysfunction in dementiaL M Allan
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
J Neurol Neurosurg Psychiatry 78:671-7. 2007There are no studies of autonomic function comparing Alzheimer's disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
- Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementiaS Srikanth
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
J Neurol Sci 236:43-8. 2005..their relationship to dementia severity and compared these disturbances in Alzheimer's disease (AD), vascular dementia (VaD) and frontotemporal dementia (FTD) using the 12-item Neuropsychiatric Inventory (NPI)...
- Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brainsMihaela O Romanitan
Laboratory of Molecular Medicine, Victor Babes National Institute of Pathology, Spl Independentei, Bucharest, Romania
J Cell Mol Med 14:1088-100. 2010..In a previous study we found in Alzheimer's disease (AD) and vascular dementia (VaD) brains an altered expression of occludin, a molecular partner of Cls in the TJs structure...
- Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical typeSang Won Seo
Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
J Neuroimaging 20:37-45. 2010..Similarly, MCI associated with small-vessel disease (svMCI), might be a forme froste of subcortical vascular dementia (SVaD)...
- Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in ratsLi Mei Zhang
Guang anmen Hospital, China Academy of Chinese Medical Science, Beijing, People s Republic of China
Neurochem Res 34:1984-92. 2009..The current study was undertaken to investigate whether H(2)S attenuates the neuronal injury induced by vascular dementia (VD)...
- Vascular basis of Alzheimer's pathogenesisJ C de La Torre
Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
Ann N Y Acad Sci 977:196-215. 2002..in motion metabolic, neurodegenerative, and cognitive changes in Alzheimer brains; (2) evidence that AD and vascular dementia (VaD) share many similar risk factors; (3) evidence that pharmacotherapy that improves cerebrovascular ..
- The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive functionH B Posner
Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Neurology 58:1175-81. 2002..Hypertension at the age of 45 to 50 years may predispose to AD later in life. It is not known whether hypertension after age 65 years also contributes to AD risk, and its effect on cognitive function is also not fully understood...
- High interleukin-6 plasma levels are associated with functional impairment in older patients with vascular dementiaG Zuliani
Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Italy
Int J Geriatr Psychiatry 22:305-11. 2007..forty older demented patients including 60 patients with late onset Alzheimer's disease (LOAD) and 80 with vascular dementia (VD)...
- Cytokines and cognition--the case for a head-to-toe inflammatory paradigmCraig J Wilson
St Vincent Institute on Aging, St Vincent Hospitals and Health Services, Indianapolis, Indiana 46260, USA
J Am Geriatr Soc 50:2041-56. 2002..of cytokine-mediated inflammatory processes in neurodegenerative diseases such as Alzheimer's disease and vascular dementia. Consistent with their involvement as mediators of bidirectional communication between the CNS and the ..
- Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalusGrant A Bateman
Department of Medical Imaging, John Hunter Hospital, Newcastle Region Mail Centre, Locked Bag 1, Newcastle 2310, Australia
Med Hypotheses 62:182-7. 2004The disorders of Alzheimer's disease, vascular dementia and normal pressure hydrocephalus are all causes of dementia in the elderly population. It is often the case that it is clinically very difficult to tell these diseases apart...
- Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy agingL Gootjes
Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Dement Geriatr Cogn Disord 18:180-8. 2004..The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease (AD) and healthy aging.
- Safe, Rapid Telomere Extension to Prevent and Treat HypertensionHelen M Blau; Fiscal Year: 2013..by short telomeres: hypertension and heart failure (Cooke and Blau labs), immunosenescence (Weyand lab), and vascular dementia (Yesavage lab) (see supporting letters)...
- Telomere extension using nucleoside-modified mRNA and exosomes as a novel therapeHelen M Blau; Fiscal Year: 2013..in our labs, Duchenne muscular dystrophy (DMD) and vascular disease, which includes atherosclerosis, vascular dementia, and heart disease...
- Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid AngiopathyAnand Viswanathan; Fiscal Year: 2013..NIH-funded clinical research study enrolling patients affected with all types of memory disorders, including vascular dementia and CAA. It was established by Dr. John Growdon and currently led by Dr...
- Domains of Inflammation and Risk of DementiaAnnette L Fitzpatrick; Fiscal Year: 2013..Subtype of dementia, i.e. AD and vascular dementia, were determined using MRI images and standardized criteria...
- O-linked glycosylation and synaptic function in hippocampusLORI LYNN contact MCMAHON; Fiscal Year: 2010..and cognitive impairment;as such diabetics have an increased risk of Alzheimer's disease and vascular dementia. Under basal conditions, glucose is processed through the glycolytic pathway;while 2-4% is process via the ..
- Role of impaired cognitive states &risk factors in conversion to mixed dementiasLei Yu; Fiscal Year: 2013..to dementia and differentiate Alzheimer's disease (AD) from other prevalent brain diseases that include vascular dementia (VaD) and Lewy body disease (LBD)...
- Fibrinogen as a molecular mediator of cognitive dysfunctionFrances Alexandra Loucks; Fiscal Year: 2010..levels of fibrinogen are linked to the onset of demetia(13) and increase the risk of developing AD and vascular dementia.(14) Studies in animal models show that fibrinogen contributes to neurological disease by exacerbating ..
- ASPirin in Reducing Events in the ElderlyJOHN JAMES MCNEIL; Fiscal Year: 2013..whether the potential benefits of this drug (particularly the prevention of heart disease, stroke and vascular dementia) outweigh the risks of severe bleeding in this age group...
- Failure of metabolite clearance in a model of multi-lacunar infarctsMaiken Nedergaard; Fiscal Year: 2013..We will test the provocative hypothesis that cognitive function in an experimental model of vascular dementia in part is suppressed by accumulation of metabolic waste products...
- Structural studies of tight junction proteinsJohn M Flanagan; Fiscal Year: 2013..tumors), stroke, retinopathies, kidney disorders, irritable bowel syndrome, Alzheimer's disease and vascular dementia, and asthma. Moreover, TJ components are used as cellular receptors by a range of pathogens...
- Vascular Risk and Cognition in a Multi-ethnic CohortClinton B Wright; Fiscal Year: 2013..These relationships are poorly understood because past definitions of vascular dementia evolved from those for Alzheimer disease...
- Role of Proteasome Inhibition in the Pathogenesis of CADASILMichael M Wang; Fiscal Year: 2010Stroke and vascular dementia are prevalent diseases which are both caused by multiple factors, including genetic susceptibility. In large part, the genetics of these disorders is complex...
- BIOMEDICAL (BASIC)ALFED CHEUNG; Fiscal Year: 2009..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
- Oligo-Vascular Signaling in StrokeKen Arai; Fiscal Year: 2013..White matter injury is a central event in the pathophysiology of diverse CNS disorders, including stroke and vascular dementia. But studies that investigate white matter are relatively uncommon in cerebrovascular research...
- Dietary and Visceral Fat Regulate Vascular Amyloid PathogenesisJEFFREY NEIL KELLER; Fiscal Year: 2012..studies suggest that increased adiposity, and specifically visceral adiposity, elevates the risk of both vascular dementia and Alzheimer's disease (AD)...
- Inflammation and delayed cognitive dysfunction after strokeKRISTIAN PAUL DOYLE; Fiscal Year: 2013..This dementia is commonly referred to as vascular dementia and its etiology is unknown...
- Notch, LRP, and MMP in Stroke and Vascular DementiaMichael M Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Stroke and vascular dementia are important disabling disorders among the veteran population...
- Growth Hormone & IGF-1 in CNS and Cerebrovascular AgingWilliam Edmund Sonntag; Fiscal Year: 2010..between endocrine and microvascular changes and the neural substrates that contribute to cognitive decline, vascular dementia and increased susceptibility to diseases commonly observed in the elderly, including Alzheimer's ..
- Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapyShaohua Yang; Fiscal Year: 2012DESCRIPTION (provided by applicant): Ischemic stroke is the major cause of vascular dementia. Epidemiological studies have suggested a progressive course of dementia after ischemia stroke...
- Epidemiology of Brain Aging in the Very OldLON RAY WHITE; Fiscal Year: 2011..of Brain Aging in the Very Old", a population-based longitudinal study of Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), mild cognitive impairment (MCI), and Parkinson's disease (PD)...
- Stroke &cognition in surgical aortic stenosisMICHAEL ANDREW ACKER; Fiscal Year: 2011..multiple cerebral infarctions in the short- term, and may be at risk for an acceleration toward long-term vascular dementia. This is a key population in which to study not only the pathogenesis of stroke and POCD, but also one in ..
- Effects of Traffic-Related Air Pollution on Cognitive Function, Dementia Risk, anJOEL DANIEL KAUFMAN; Fiscal Year: 2011..will include cognitive performance, prevalent and incident dementia (both Alzheimer's disease and vascular dementia), presence of MRI-detected brain abnormalities including brain infarcts and white matter disease, and ..
- Blood-Brain Barrier in NeuroinflammationANUSKA V ANDJELKOVIC-ZOCHOWSKA; Fiscal Year: 2012..BBB leaking is seen in many disease states like Alzheimer and Parkinson disease, vascular dementia, and epilepsy but also in the process of BBB recovery after ischemic episodes or inflammation...
- Influence of Age-related Neuropathology on Functional Brain NetworksJULIUS C HEDDEN; Fiscal Year: 2013..White matter integrity, commonly disrupted in vascular dementia, will be measured using structural magnetic resonance imaging (MRI)...
- Genetic Epidemiology of Cerebrovascular Disease and Cognition in DiabetesDonald W Bowden; Fiscal Year: 2012..Dementia due to cerebrovascular disease is often referred to as vascular dementia" or vascular cognitive impairment (VCI)...
- Molecular Features of and Approach to the HIV CNS Reservoir Post cARTMICHAEL SHANNON MCGRATH; Fiscal Year: 2013..of atherosclerosis as a significant comorbidity in HIV-infected patients, it appears that a variation of vascular dementia may be becoming more frequent, implicating a potentially new type of HIV-associated CNS pathogenesis...
- Delayed cognitive impairment after strokeMarion S Buckwalter; Fiscal Year: 2013..All-cause dementia, (vascular dementia, Alzheimer's disease, and mixed disorders) is diagnosed in up to 48% of stroke survivors, with about 20%..
- Mechanisms of Neural Repair in White Matter StrokeSTANLEY THOMAS CARMICHAEL; Fiscal Year: 2013..White matter strokes are a source of significant disability and can accumulate to cause vascular dementia, the second leading cause of dementia...
- SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES (SPS3)Oscar R Benavente; Fiscal Year: 2012..S3 are usually due to small vessel disease, a common substrate for vascular dementia. Over two million survivors of S3 are at risk for recurrent stroke and for vascular dementia;millions more ..
- Secondary Prevention of Subcortical Stroke Prevention Genetic SubstudyAlan R Shuldiner; Fiscal Year: 2013..HEALTH RELEVANCE: Small subcortical strokes (S3) are a common stroke subtype and contribute importantly to vascular dementia. The SPS3 trial seeks to define optimal treatment approaches with antiplatelet and antihypertensive ..
- First Person Vision for Objective Evaluation of Caregiving QualityJUDITH T MATTHEWS; Fiscal Year: 2013..MMSE score <18) due to Alzheimer's disease, frontal temporal dementia, Lewy body dementia, or vascular dementia. Baseline data will include demographic, health, and caregiving information including problem behaviors, ..
- Daily Functioning, Cognition, and Caregiver Burden in MCI PatientsLALEH JILL RAZANI; Fiscal Year: 2013..compared to a database of individuals with dementia (Alzhiemer's disease, Frontotemporal dementia, and Vascular dementia) and normal controls...
- Gene-Environment Interaction in Cognition in Venezuelan FamiliesJOSEPH DOUGLAS TERWILLIGER; Fiscal Year: 2013..Ischemic small vessel disease (SVD) is a leading cause of vascular dementia and a major contributor to Alzheimer's disease...
- Functional Decline in Three Dementia TypesWALTER ANTHONY KUKULL; Fiscal Year: 2012..research and clinical care as to expected rates of functional decline in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB), and differences among these dementia types...
- Dorsal Cingulate Activity and Cognitive Decline in Late-Life DepressionLihong Wang; Fiscal Year: 2013..with cognitive decline over years have an increased risk of developing either Alzheimer's disease or vascular dementia. Identifying individuals who are at risk for developing cognitive decline is vital for early intervention ..
- Abnormal Low Density Lipoprotein Receptor Localization and Function in ADHuntington Potter; Fiscal Year: 2013..roles that atherosclerosis and Abeta play in the pathogenesis of co-morbid Alzheimer's disease (AD) and vascular dementia. Although, most of the field's efforts have been focused on the role of LDL, ApoE and their receptors ..
- BIOMEDICAL (BASIC)David C Goff; Fiscal Year: 2009..intervention wil reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and 3...
- PFC-MTL Interactions During Controlled Episodic RetrievalJENNIFER LEIGH BARREDO; Fiscal Year: 2012..of neurological disease and a feature of many prevalent neuropsychological disorders such as ischemic vascular dementia and Alzheimer's and Parkinson's Diseases and the memory deficits that accompany healthy aging and ..
- ISOLATED EXECUTIVE IMPAIRMENT AND COGNITIVE DECLINEJulene K Johnson; Fiscal Year: 2010..in future primary prevention and treatment trials, and 3) expand differential diagnosis with individuals who present with isolated executive impairment to include AD in addition to frontotemporal dementia, vascular dementia, etc.
- BIOMEDICAL (BASIC)Jackson Wright; Fiscal Year: 2009..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
- SPRINTSuzanne Oparil; Fiscal Year: 2009..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
- qBead Assessment of miRNA in Alzheimer's DiseaseBruce E Seligmann; Fiscal Year: 2012..disease and dementia (PD), patients with cerebrovascular disease neuropathologically diagnosed as vascular dementia (VaD), and normal controls (NC)...
- A Composite MR NeuroImaging Marker for Alzheimer's DiseaseShi Jiang Li; Fiscal Year: 2013..and distinguish mild AD from other types of non-AD dementia, such as frontotemporal dementia (FTD) and vascular dementia (VaD)...
- A platelet ligand mimetic for neurothrombotic disordersCatherine Woods; Fiscal Year: 2006..complications in disorders such as thrombotic thrombocytopenic purpura (TTP), cerebral malaria, meningitis vascular dementia and Alzheimer's Disease (AD) where localized recruitment of activated platelets within the CNS ..
- EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANSEric Larson; Fiscal Year: 2000..S. are similar, the relative prevalence of Alzheimer's disease (AD) to vascular dementia (VaD) is much greater in the U.S...
- TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITISFrank LaFerla; Fiscal Year: 2001..the first disease, other than those disorders related to Alzheimer's disease such as Down syndrome and vascular dementia, where pathological accumulation of the beta-amyloid peptide occurs outside the central nervous system...
- 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of DementiaFranz Hefti; Fiscal Year: 2009..with its most prevalent subforms Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia, is a very substantial medical and societal problem...
- Chinese Dementia Care Research CenterSue Levkoff; Fiscal Year: 2009..85% prevalence of Alzheimer's disease among individuals aged 65 and over, and a 1.1% prevalence of Vascular Dementia;thus, China is not a low risk nation for dementia...
- Cognitive Enhancers Explored with PET ImagingSusan Schultz; Fiscal Year: 2003..g., vascular dementia) by establishing their effects on CNS hemodynamics and cognitive function in the elderly adult...
- VISUAL INTERVENTIONS TO IMPROVE ALZHEIMER COGNITIONAlice Cronin Golomb; Fiscal Year: 2004..young adults, and 160 demented patients, of whom 50% will be diagnosed with probable AD and 35 percent with Vascular Dementia. The remainder will include Lewy Body and Frontotemporal Dementias...
- Depression as a Risk Factor for DementiaJESSICA BROMMELHOFF; Fiscal Year: 2009..Analyses will be conducted for total dementia and for Alzheimer's disease or vascular dementia alone...
- Varian 4 Tesla MRI/MRS for Neuro-degenerative DiseasesMichael Weiner; Fiscal Year: 2002..clinical collaborators have funded projects on normal aging, Alzheimer's disease, frontotemporal dementia, vascular dementia, Lewy Body disease, epilepsy, Parkinson's disease, amyotrophic lateral sclerosis, post traumatic stress ..
- HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTSSHARI WALDSTEIN; Fiscal Year: 2002DESCRIPTION: Hypertension is a major risk factor for cerebral infarction, intracranial hemorrhage, and vascular dementia, particularly among older adults...
- Notch3 signaling in small-artery-diseasesAnne Joutel; Fiscal Year: 2009Small-vessel-diseases are a leading cause of Vascular Dementia. Our long-term goal is to elucidate the signaling pathways that control the structural and functional integrity of small arteries and understand the connections between these ..
- Cong Intl. Soc Vascular Behavioral & Cognitive DisordersROBERT FRIEDLAND; Fiscal Year: 2005Interest in the vascular causes of various brain disorders including Alzheimer's disease, vascular dementia, mild cognitive impairment, depression, and other behavioral disorders has grown immensely over the last decade...
- AGGRESSION AND VIOLENCE IN COMMUNITY BASED AD FAMILIESGregory Paveza; Fiscal Year: 1999..Type according to DSM-III-R or Dementia of the Alzheimer's Type according to DSM-IV or with mixed AD and vascular dementia, with an initial diagnosis of AD or mixed AD made at least one year prior to being contacted for the study...
- Prevalence of Post-Stroke Dementia in MexicoClaudia Diaz; Fiscal Year: 2007..and the United States, to determine the incidence, prevalence, risk factors and potential for prevention of vascular dementia and other forms of dementia in Mexico...
- Memory Impairment Screen and Decision Support CD-ROMROBERT RAGER; Fiscal Year: 2001..and telephone forms, shows high reliability, validity, sensitivity and specificity for preclinical AD and vascular dementia (VaD)...
- STRIATAL AMPA RECEPTOR PATHOLOGY IN SCHIZOPHRENIAJOHN NOGA; Fiscal Year: 2002..presenting with psychotic symptoms and cognitive impairment such as schizophrenia, Alzheimer's disease, vascular dementia, and Parkinson's disease in which glutamatergic systems have been increasingly implicated in pathological ..
- ALCOHOL, AGING AND DEMENTIA--NEUROPSYCHOLOGICAL EFFECTSJudith Saxton; Fiscal Year: 2000..applies to a number of disorders including Alzheimer's disease (AD) (the most frequent cause of dementia), Vascular dementia and Pick's disease...
- SUNDOWN SYNDROME IN A SKILLED NURSING FACILITYDonald Bliwise; Fiscal Year: 2002..cycle and sleep/wakefulness in elderly patients with Alzheimer's Disease (AD), Parkinson's Disease (PD), Vascular Dementia (VasD) and aged matched controls...
- MMP-7 and SNARE Cleavage in NeuroinflammationKatherine Conant; Fiscal Year: 2009..Moreover, elevated expression of MMPs has been reported in Alzheimer's disease, vascular dementia, and HIV-associated dementia...
- COGNITIVE CHANGE IN CEREBROVASCULAR DISEASEJohn Morris; Fiscal Year: 2000Cerebrovascular disease is a major cause of dementia and is potentially preventable. However, vascular dementia is poorly characterized and its true prevalence is unknown...